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Дисертації з теми "Matrice MALDI"

Автор: Grafiati

Опубліковано: 22 грудня 2023

Оновлено: 31 липня 2025

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1

Manuelli, Pascal. "Etude des mécanismes de la désorption : ionisation laser assistée par matrice." Metz, 1995. http://docnum.univ-lorraine.fr/public/UPV-M/Theses/1995/Manuelli.Pascal.SMZ9520.pdf.

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Ce mémoire sur les mécanismes de la désorption/ionisation laser assistée par matrice (MALDI) est le fruit de travaux réalisés au laboratoire de spectrométrie de masse et de chimie laser (LSMCL) de l'université de Metz. Cette thématique est apparue au laboratoire suite au développement de l'analyse des biomolécules par spectrométrie de masse et à l'expérience accumulée depuis 15 ans sur la désorption laser. Nous nous sommes attachés à décomposer les étapes constituant une analyse MALDI afin de mieux comprendre les mécanismes mis en jeu lors de ce type d'ionisation. Nous avons plus précisément,

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2

Jaber, Ali. "Matrices MALDI bithiophéniques spécifiques aux alcaloïdes : étude des mécanismes fondamentaux et applications." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0042/document.

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Mon travail de thèse a consisté à poursuivre le développement et l’application des matrices bithiophéniques spécifique aux alcaloïdes. Après l’optimisation d’un protocole efficace d’analyse, adapté à l’objectif de l’étude, la mise au point d’une méthode de dosage des alcaloïdes par MALDI dans des extraits végétaux et sans prétraitement préalable a été étudiée. Cette méthode a pu être validée en étudiant des alcaloïdes existant dans différents extraits des plantes toxiques. Ensuite, la synthèse et l’évaluation de nouveaux composés bithiophéniques ont été présentés de manière à évaluer les facte

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3

Lavigne, Damien. "Conception de surfaces de matrice extracellulaire analysables en spectrométrie de masse SELDI-TOF." Paris 7, 2008. http://www.theses.fr/2008PA077247.

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Notre projet a pour objectif de concevoir des surfaces de matrice extracellulaire (MEC) sur des chips analysables en spectrométrie de masse SELDI-TOF (Surface Enhanced Laser Desorption lonization Time Of Flight). La MEC est synthétisée directement par les cellules en culture sur les chips. Le décollement des cellules par un traitement permet ensuite d'obtenir une surface de MEC. Parmi les chips en aluminium commerciales, seules les surfaces de silice permettent la culture des cellules musculaires lisses (hCML) et endothéliales (HUVEC) humaines et d'obtenir de la MEC. La MEC de ces deux types c

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4

Xu, Zeyuan. "PTMomics : Microfluidics for post-translational modifications studies : application to glycoproteomics." Electronic Thesis or Diss., Université Paris sciences et lettres, 2023. http://www.theses.fr/2023UPSLS029.

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Анотація:

Les glycoprotéines jouent un rôle fondamental dans la vie. Des études récentes montrent qu'elle est largement présente dans les activités biologiques, telles que la liaison des récepteurs, la signalisation cellulaire, la réponse immunitaire, le repliement des protéines et l'action des hormones. Parallèlement, la glycosylation des protéines a été associée au pronostic et à l'évolution de maladies comme les cancers. Ainsi, elle devient un biomarqueur important, et est également significative pour le développement thérapeutique. La glycosylation mérite donc d'être étudiée en détail. La glycoproté

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5

Guerandel, Cyril. "Etude de la qualité du piégeage des matières organiques par la matrice cimentaire vis-à-vis de la lixiviation." Thesis, Metz, 2009. http://www.theses.fr/2009METZ030S/document.

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Dans le cadre de la qualité environnementale des matériaux, il est essentiel d'apporter la preuve que les matériaux à base de ciments adjuvantés ne relarguent pas ou peu de matières organiques lors de leur contact avec l'eau constituant une solution lixiviante. Les additifs organiques, tels que les agents de mouture et les superplastifiants, constituent deux classes d'adjuvants organiques utilisés de manière systématique dans la fabrication ou la formulation des matériaux cimentaires, notamment quand ils sont en contact avec l'eau potable (conduites et châteaux d'eau). Pour évaluer le piégeage

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6

Alves, Sandra. "Une échelle acido-basique pour une meilleure compréhension du rôle de la matrice dans la production d'ions multichargés : une approche thermo-cínétique de l'ionisation en mode MALDI." Paris 6, 2002. http://www.theses.fr/2002PA066005.

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7

Mallah, Khalil. "In depth systemic biology analysis of central nervous system injuries." Thesis, Lille 1, 2018. http://www.theses.fr/2018LIL1S108/document.

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Dans un contexte d’étude des altérations biologiques survenant après un impact sur le système nerveux central (SNC), ma thèse porte sur l’étude des modifications protéomiques et lipidiques survenant après une lésion du SNC. Une étude spatio-temporelle a été menée sur un modèle TBI de rat afin d'identifier des marqueurs spécifiques de la lésion. En utilisant le MALDI-MSI, nous avons effectués une reconstruction 3D du cerveau lésé 3 jours post-lésion et nous avons représentés les molécules lipidiques spécifiques à la lésion. Après, cette analyse est réalisé avec d’autres délais après l’impact: 1

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8

Crank, Jeffrey Aaron. "Ionic liquids MALDI-MS matrices and gas chromatography stationary phases /." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3379180.

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9

Hellwig, Nils [Verfasser]. "Das Laserablationsverhalten von ionischen Flüssigkeiten verschiedener MALDI-Matrices / Nils Hellwig." Kiel : Universitätsbibliothek Kiel, 2012. http://d-nb.info/1025465121/34.

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10

Allwood, Daniel Anthony. "Characterisation and ionisation modelling of matrices in MALDI mass spectrometry." Thesis, University of Hull, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301477.

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11

Kirmess, Kristopher Michael. "Investigation of Primary Ion Formation Mechanisms in UV-MALDI-MS Using Excited State Dynamics of Common MALDI Matrices." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/1110.

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Анотація:

The motivation of this dissertation is to provide insight towards primary ionization mechanisms within MALDI mass spectrometry. Albeit MALDI-MS is an extensively used analytical technique, the mechanism in which primary ions are created is still under scrutiny. Two current models of primary ionization exist which claim to elucidate the ion formation mechanisms within MALDI. In this work, excited state dynamics of MALDI matrices are shown to play an important role in the ionization mechanism. Upon inspection of the thermodynamic properties of commonly used MALDI matrices, no correlation was

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12

Jacksén, Johan. "Improved techniques for CE-MALDI-MS off-line coupling and MALDI-MS analysis of primarily hydrophobic proteins and peptides." Licentiate thesis, KTH, Chemistry, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4599.

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<p>Due to the hydrophobic nature of integral membrane proteins (IMP) they give rise to several difficulties concerning handling and analysis, which is not the case for the most water soluble proteins. New analysis methods are needed, where the insolubility problems of the hydrophobic proteins due to aggregation and adhesion are tackled. Those problems also affect digestion performance and equipment compatibility for the analysis.</p><p>Protocols for analysis and separation specified for IMP are presented in <b>Paper I</b> and<b> III</b>.</p><p>The instrumentation used in this work was capillar

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13

Krüger, Ralf. "Untersuchungen zum Einbau von Analytionen in MALDI-Matrizes sowie zur Ionisation und Adduktbildung in der MALDI-Massenspektrometrie." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969681682.

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14

Bronzel, Júnior João Luiz [UNESP]. "Matrizes iônicas: detecção e quantificação de cianotoxinas por maldi-ms." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/143001.

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Анотація:

Made available in DSpace on 2016-08-12T18:48:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-08-06. Added 1 bitstream(s) on 2016-08-12T18:51:01Z : No. of bitstreams: 1 000854199.pdf: 5245942 bytes, checksum: 78603c065ca6ba2cb04fe0531fde9643 (MD5)<br>A técnica de ionização MALDI (Matrix-Assisted Laser Desorption/Ionization) foi uma das responsáveis por revolucionar a Espectrometria de Massas, tornando possível sua aplicação a moléculas termolábeis e de alta massa molecular, como as proteínas. Apesar de seu grande desenvolvimento, esta técnica ainda apresenta algumas limitações como

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15

Bronzel, Júnior João Luiz. "Matrizes iônicas : detecção e quantificação de cianotoxinas por maldi-ms /." Araraquara, 2015. http://hdl.handle.net/11449/143001.

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Orientador: Humberto Márcio Santos Milagre<br>Banca: Eduardo Maffud Cilli<br>Banca: José Augusto Rosário Rodrigues<br>Resumo: A técnica de ionização MALDI (Matrix-Assisted Laser Desorption/Ionization) foi uma das responsáveis por revolucionar a Espectrometria de Massas, tornando possível sua aplicação a moléculas termolábeis e de alta massa molecular, como as proteínas. Apesar de seu grande desenvolvimento, esta técnica ainda apresenta algumas limitações como a seleção da matriz utilizada e o método de preparo de amostras. Estes fatores são determinantes na reprodutibilidade da análise e na fa

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16

Bouschen, Werner. "Ortsaufgelöste MALDI-Massenspektrometrie an biologischen und synthetischen Oberflächen." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971766886.

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17

Börjesson, Erik. "Undersökning av jonvätskematrisers detektion på olika typer av MALDI plattor." Thesis, KTH, Skolan för kemivetenskap (CHE), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-195847.

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Examensarbetet gjordes för att undersöka om det istället för 2,5-dihydroxidbensoesyra fanns en jonvätskematris som hade en lika bra eller bättre detektionsgrad. Examensarbetet undersökte också om det var någon detektions skillnad på stål- och koncentrationsplatta när analysmetoden matris-assisterande laser desorption-jonisation-masspektrometri (MALDI-MS) analysmetod används. Jonvätskematris är en matris som binder till en svag bas och är till för att skydda peptiderna från addukter. Baserna som undersöktes var etylamin, dietylamin, diisopropylamin och N,N-etyl-diisopropylamin. Examensarbetet j

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18

Siricord, Cornelia Charito. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Thesis, Siricord, Cornelia Charito (2005) Detection of Phytophthora species by MALDI-TOF mass spectrometry. PhD thesis, Murdoch University, 2005. https://researchrepository.murdoch.edu.au/id/eprint/314/.

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Phytophthora diseases have caused worldwide economic, social and environmental impacts for decades. Once their presence is confirmed, they are difficult to eradicate. To reduce and manage the damage inflicted by the pathogen, fast and reliable disease management protocols are required. Tests that enable the rapid and reliable identification of the pathogen assist greatly in disease management. Phytophthora species are traditionally not only detected by baiting but also by plating of symptomatic tissue on selective media. Species can be identified by the characteristics of the mycelium growi

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19

Siricord, Cornelia Charito. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Siricord, Cornelia Charito (2005) Detection of Phytophthora species by MALDI-TOF mass spectrometry. PhD thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/314/.

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Анотація:

Phytophthora diseases have caused worldwide economic, social and environmental impacts for decades. Once their presence is confirmed, they are difficult to eradicate. To reduce and manage the damage inflicted by the pathogen, fast and reliable disease management protocols are required. Tests that enable the rapid and reliable identification of the pathogen assist greatly in disease management. Phytophthora species are traditionally not only detected by baiting but also by plating of symptomatic tissue on selective media. Species can be identified by the characteristics of the mycelium growi

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20

Mériaux, Céline. "Imagerie du système nerveux central par spectrométrie de masse MALDI." Thesis, Lille 1, 2011. http://www.theses.fr/2011LIL10059/document.

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Ces dernières années, l’imagerie par spectrométrie de masse MALDI s’est révélée être un outil puissant pour la recherche de biomarqueurs puisqu’elle permet d’effectuer l’analyse d’un large panel de composés endogènes et exogènes dans des coupes de tissu. Des développements restent néanmoins à faire pour l’amélioration de la détection des molécules. La préparation de l’échantillon, incluant les traitements chimiques et le dépôt de la matrice, est dépendante du tissu et des molécules d’intérêt et influence la qualité des spectres et des images. D’autre part, les outils bioinformatiques tels que

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21

Luizete, Milena Fontes. "Aplicações de MALDI-MS na análise de peptídeos produzidos por cianobactérias /." Araraquara, 2017. http://hdl.handle.net/11449/151215.

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Orientador: Humberto Márcio Santos Milagre<br>Banca: Saulo Santesso Garrido<br>Banca: Dulce Helena Siqueira Silva<br>Banca: Moacir Rossi Forin<br>Banca: João Henrique Ghilardi Lago<br>Resumo: Neste trabalho, a técnica Matrix Assisted Laser Dersoption/Ionization - Mass Spectrometry (MALDI-MS) foi utilizada em diferentes aplicações para a análise de peptídeos produzidos por cianobactérias. Esta técnica é extremamente rápida, possui alta resolução, requer pouquíssimo preparo de amostra e não permite que possíveis contaminantes presentes na amostra interfiram na análise. Por estes motivos MALDI- M

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22

Lemaire, Rémi. "Nouveaux développements pour l'imagerie par spectrométrie de masse MALDI : applications aux problèmes biologiques et à la recherche de biomarqueurs dans le cancer de l'ovaire." Paris 6, 2006. http://www.theses.fr/2006PA066288.

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23

Robins, Chad LaJuan. "Nonpolar matrices for matrix assisted laser desportion ionization - time of flight - mass spectrometry." Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1115293526.

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Анотація:

Thesis (Ph. D.)--University of Cincinnati, 2005.<br>Title from electronic thesis title page (viewed May 18, 2006). Includes abstract. Keywords: Matrix Assisted Laser Desorption/Ionization Mass Spectrometry; MALDI; Nonpolar Matrices; Charge-Transfer Ionization; Crude Oil; Mass Spectrometry. Includes bibliographical references.

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24

Crumpton, Jason. "Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/77076.

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Анотація:

The utilization of click chemistry to perform inter- and intramolecular ligation on DNA has become ubiquitous in the literature. Advances in copper (I) stabilizing ligands that prevent DNA degradation via redox pathways have provided nucleic acid researchers access to the efficiency and quantitative nature of the click reaction. The majority of ligation procedures in the literature are performed in solution after DNA assembly and modification with alkyne reporter groups. However, without specialty alkyne reagents that can be sequentially and selectively deprotected, the solution phase method r

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25

Crumpton, Jason B. "Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77076.

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Анотація:

The utilization of click chemistry to perform inter- and intramolecular ligation on DNA has become ubiquitous in the literature. Advances in copper (I) stabilizing ligands that prevent DNA degradation via redox pathways have provided nucleic acid researchers access to the efficiency and quantitative nature of the click reaction. The majority of ligation procedures in the literature are performed in solution after DNA assembly and modification with alkyne reporter groups. However, without specialty alkyne reagents that can be sequentially and selectively deprotected, the solution phase method r

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26

Walton, Barbara Lynn. "A Study of Silver: an Alternative Maldi Matrix for Low Weight Compounds and Mass Spectrometry Imaging." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc499981/.

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Soft-landing ion mobility has applicability in a variety of areas. The ability to produce material and collect a sufficient amount for further analysis and applications is the key goal of this technique. Soft-landing ion mobility has provided a way to deposit material in a controllable fashion, and can be tailored to specific applications. Changing the conditions at which soft-landing ion mobility occurs effects the characteristics of the resulting particles (size, distribution/coverage on the surface). Longer deposition times generated more material on the surface; however, higher pressur

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27

Lu, Kuan. "Optimization Of Sublimation Conditions for Surface Layer Matrix-assisted Laser Desorption Ionization Time of Flight Mass Spectrometry Imaging (SL-MALDI- Tof MSI) of Polymer Surfaces." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524846943404769.

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28

Jacksén, Johan. "Improved techniques for CE and MALDI-MS including microfluidic hyphenations foranalysis of biomolecules." Doctoral thesis, KTH, Analytisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-27342.

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Анотація:

In this thesis, improved techniques for biomolecule analysis using capillary electrophoresis (CE) and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and hyphenations between those have been presented.A pre-concentration method which is possible to apply in both techniques, has also been investigated. In this work the off-line MS mode has been used either in the form of fractionation (Paper I) or by incorporating the MALDI target in the CE separation system (Paper II).In Paper I, a protocol for CE-MALDI analysis of cyanogen bromide digested bacteriorhodopsin (BR) pepti

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29

Sorensen, Christina M. "ESI-MS and MALDI-TOF-MS for the characterization and analysis of metallo-oligomers and proteins." Laramie, Wyo. : University of Wyoming, 2005. http://proquest.umi.com/pqdweb?did=1031044031&sid=4&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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30

Hoteling, Andrew J. "MALD/I TOF PSD and CID : understanding precision, resolution, and mass accuracy and MALD/I TOFMS : investigation of discrimination issues related to solubility /." Philadelphia, Pa. : Drexel University, 2004. http://dspace.library.drexel.edu/handle/1860/318.

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31

Júnior, João Nobrega de Almeida. "Padronização da espectrometria de massa MALDI-TOF para identificação de cepas de Trichosporon spp. de importância médica." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-05052014-110905/.

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Анотація:

O gênero Trichosporon é composto por leveduras artrosporadas do Filo Basidiomycota e é conhecido agente de infecção fúngica invasiva (IFI) em pacientes imunodeprimidos ou com outros fatores de risco. Em pacientes onco-hematológicos é a principal levedura responsável por IFI depois do gênero Candida. Entre as espécies responsáveis por infecções no homem encontram-se: T. asahii, T. inkin, T. mucoides, T. dermatis, T. jirovecii, T. ovoides, T. cutaneum, T. montevideense, T. domesticum, T. asteroides, T. coremiiforme, T. faecale, T. dohaense, T. lactis, T. japonicum. A tecnologia de identificação

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32

Holcomb, April M. Owens Kevin G. "Investigation into the ionization mechanism occurring in matrix assisted laser desorption ionization and factors affecting ion flight time in MALDI time-of-flight mass spectrometry /." Philadelphia, Pa. : Drexel University, 2009. http://hdl.handle.net/1860/3161.

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33

Åminne, Ann. "Evaluation of preanalytic methods in order to shorten the processing time before identification of fungal microorganisms by the MALDI-TOF MS." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255132.

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Анотація:

Identification of fungi is based on macroscopic observations of morphology and microscopic characteristics. These conventional methods are time-consuming and requires expert knowledge. For the past years Matrix-assisted laser desorption ionization-time of flight mass spectrometry has been used for routine bacterial identification in clinical laboratories but not yet in the same extension for fungi. In this study three preanalytic preparation methods for fungi were evaluated in order to shorten the processing time in routine laboratory performance. Clinically relevant strains (n=18) of molds an

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34

Andrade, Laíse de Oliveira. "Métodos rápidos para identificação microbiana aplicados ao monitoramento ambiental de salas limpas: ênfase na tecnologia MALDI-TOF." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-26102017-114152/.

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Анотація:

A espectrometria de massas baseada na tecnologia MALDI-TOF (do inglês, matrix-assisted laser desorption ionization-time of flight) (MALDI-TOF MS) tem sido cada vez mais incorporada à rotina de identificações microbiológicas nos laboratórios farmacêuticos de controle de qualidade, principalmente para as atividades do Programa de Monitoramento Ambiental de Salas Limpas. Isso porque o longo tempo necessário para a obtenção dos resultados por meio de métodos convencionais tem incentivado a procura por técnicas que permitam métodos rápidos. O objetivo deste trabalho foi avaliar a adequação da técni

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35

Gibb, Sebastian. "Entwicklung einer flexiblen bioinformatischen Plattform zur Analyse von Massenspektrometriedaten." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-178678.

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Sowohl in der Klinischen Labormedizin, der Klinischen Mikrobiologie als auch in der Pathologie ist die Massenspektrometrie (MS) ein bedeutender Bestandteil der Diagnostik geworden. Der Fortschritt in der Gerätetechnik ermöglicht in kurzer Zeit viele, hochaufgelöste Spektren zu generieren. Diese Informationsvielfalt macht die manuelle Auswertung durch den Anwender sehr kompliziert bis unmöglich. Aus diesem Grund ist die Unterstützung durch bioinformatische Programme notwendig. Für die Reproduzierbarkeit der Ergebnisse und die Qualitätskontrolle ist es essentiell, dass die verwendeten Algorithme

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Emanuele, Vincent A. II. "Advancements in high throughput protein profiling using surface enhanced laser desorption/ionization time of flight mass spectrometry." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37287.

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Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI)is one of several proteomics technologies that can be used in biomarker discovery studies. Such studies often have the goal of finding protein markers that predict early onset of cancers such as cervical cancer. The reproducibility of SELDI has been shown to be an issue in the literature. There are numerous sources of error in a SELDI experiment starting with sample collection from patients to the signal processing steps used to estimate the protein mass and abundance values present in a sample. This dissertat

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Watson, R. Craig Jr. "Laser-Ionization Time-of-Flight Mass Spectrometry of High Molecular Mass Inorganic Complexes." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/35554.

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Laser-Ionization Time-of-Flight Mass Spectrometry (LI-TOF-MS) is a sophisticated tool for the molecular-weight determination and structural characterization of a variety of molecules. Advances in instrumentation and ionization methods have recently expanded its role in the analysis of high-mass analytes. Large multimetallic complexes, which are efficient solar-energy converters, rely heavily on their chemical structure for optimum operation. Molecular mass determinations of these multimetallic complexes have been problematic due to their lability and high molecular weights. <p> This thesi

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Saleem, Saira. "Proteomic profiling of pro and active matrix metalloproteinases using tandem mass spectrometry. optimization of affinity chromatography and nHPLC-MALDI-MS/MS for proteomic discrimination of matrix metalloproteinases in pre-clinical cancer model." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5752.

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Matrix metalloproteinases (MMPs) network with other biological molecules to maintain the extracellular matrix (ECM) in normal physiology and perform different roles. Understanding and assigning specific role to each of 24 members of these endoproteinases is impeded because of lack of specific and efficient detection methods in biological samples. Moreover, MMP-based anti-cancer drug development has also been challenged because, currently, there is no robust methodology to distinguish the inactive pro-enzymes, active enzymes or those complexed with endogenous inhibitors in biological specimens.

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Jung, Seokwon. "Surface characterization of biomass by imaging mass spectrometry." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45906.

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Lignocellulosic biomass (e.g., non food-based agricultural resides and forestry wastes) has recently been promoted for use as a source of bioethanol instead of food-based materials (e.g., corn and sugar cane), however to fully realize these benefits an improved understanding of lignocellulosic recalcitrance must be developed. The primary goal of this thesis is to gain fundamental knowledge about the surface of the plant cell wall, which is to be integrated into understanding biomass recalcitrance. Imaging mass spectrometry by TOF-SIMS and MALDI-IMS is applied to understand detailed spatial a

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Kuismin, M. (Markku). "On regularized estimation methods for precision and covariance matrix and statistical network inference." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220802.

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Abstract Estimation of the covariance matrix is an important problem in statistics in general because the covariance matrix is an essential part of principal component analysis, statistical pattern recognition, multivariate regression and network exploration, just to mention but a few applications. Penalized likelihood methods are used when standard estimates cannot be computed. This is a common case when the number of explanatory variables is much larger compared to the sample size (high-dimensional case). An alternative ridge-type estimator for the precision matrix estimation is introduced i

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Borchardt, Lars, and Sven Grätz. "Mechanochemical polymerization – controlling a polycondensation reaction between a diamine and a dialdehyde in a ball mill." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-221833.

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The mechanochemical polycondensation between a diamine and a dialdehyde constitutes a sustainable alternative to classical solvent-based polymerization reactions. This process not only allows for a higher conversion and a shorter reaction time as compared to standard solvent-based syntheses of this conjugated polymer, but the reaction can also be adjusted by the energy introduced via the ball mill.

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Borchardt, Lars, and Sven Grätz. "Mechanochemical polymerization – controlling a polycondensation reaction between a diamine and a dialdehyde in a ball mill." Royal Society of Chemistry, 2016. https://tud.qucosa.de/id/qucosa%3A30231.

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The mechanochemical polycondensation between a diamine and a dialdehyde constitutes a sustainable alternative to classical solvent-based polymerization reactions. This process not only allows for a higher conversion and a shorter reaction time as compared to standard solvent-based syntheses of this conjugated polymer, but the reaction can also be adjusted by the energy introduced via the ball mill.

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Magalhães, Ilídio Miguel Teixeira. "Proteome of biofilm produced by a S. pseudintermedius strain." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14291.

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Mestrado em Bioquímica<br>Staphylococcus pseudintermedius is an opportunistic pathogenic bacterium responsible for most skin and post-surgical infections in dogs. The number of bacterial strains resistant to β-lactam antibiotics is increasing and are the major challenges now faced by veterinary medicine. Bacteria that produce biofilm are more resistant to treatment and thus, the production of this structure is already considered a virulence factor. In a biofilm, bacteria are embedded in a matrix of extracellular polymeric substances (EPS) some of which are proteins. With the objective to know

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Agatea, Lisa. "An integrated proteomic and genomic approach to study FAP patients without APC and MutHY mutations." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424509.

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Familial Adenomatous Polyposis (FAP) is one of the most important clinical forms of inherited susceptibility to colorectal cancer, that is characterized by the development of hundreds to thousands of adenomas in the colon and rectum during the second decade of life. FAP is due to a germline mutation in the APC gene or to biallelic variations of MutYH gene. Almost all patients will develop cancer if the disease is not identified and surgically treated at an early stage. The aim of this study was to characterize, by peptidomic and genetic approaches, 4 pa-tients that, although at the colonoscop

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Ochoa, Mariela L. "Forensic and Proteomic Applications of Thermal Desorption Ion Mobility Spectrometry and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry." Ohio University / OhioLINK, 2005. http://www.ohiolink.edu/etd/view.cgi?ohiou1113585811.

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Macháčková, Petra. "Nové matrice pro MALDI-MS analýzu lipidů." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-298002.

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In this work focused on research of new matrices for MALDI-MS analysis of lipids several organic salts were tested as potential matrices for hydrocarbons and wax esters. It was shown previously that the effective ionization of lipids occurs in conjuction with a lithium cation to form adducts [M + Li] + . Therefore, lithium salts of aromatic acids were synthesized. Matrices were evaluated according to their MALDI properties and compared with lithium 2,5-dihydroxybenzoate, which is proven matrix for MALDI analysis of lipids. It was found that effectiveness of matrix depends on presence of hydrox

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Aiello, Donatella, Anna Napoli, Giovanni Sindona, and Bartolo Gabriele. "Protein characterization from natural matrices by maldi tof-tof." Thesis, 2014. http://hdl.handle.net/10955/443.

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Yang, Siao-Huei, and 楊筱蕙. "Concentration and Analysis of Peptides Using MALDI Ionic Liquid Matrices." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/93447220048370658723.

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碩士<br>國立東華大學<br>化學系<br>97<br>Sample preparation procedures such as desalting and concentration are key steps for a successful MALDI analysis of biological samples. A new approach of using ionic liquid matrix (ILM) α-cyano-4-hydroxycinnamate/3-aminoquinoline (CCA/3-AQ) as a solvent for the separation and preconcentration of peptides in aqueous samples prior to analysis by MALDI has been demonstrated. The samples were analyzed in-situ after the extraction without further sample transfer. Liquid liquid microextraction and single drop microextraction were employed for the extraction of peptides. M

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Li, Zong-Sian, and 李宗憲. "Qualitative Analysis of Peptides and Proteins by MALDI-TOF Mass Spectrometry Using Liquid Matrices." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/55156337709886526601.

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Krüger, Ralf [Verfasser]. "Untersuchungen zum Einbau von Analytionen in MALDI-Matrizes sowie zur Ionisation und Adduktbildung in der MALDI-Massenspektrometrie / vorgelegt von Ralf Krüger." 2003. http://d-nb.info/969681682/34.

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