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Дисертації з теми "Mechanism for regulating"

Автор: Grafiati

Опубліковано: 28 травня 2022

Оновлено: 31 липня 2025

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1

Kveiborg, Ole. "Regulating road transport using mechanism design /." København, 2003. http://www.gbv.de/dms/zbw/364082461.pdf.

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2

Leftley, Nicola J. "Dissecting the molecular mechanism regulating lateral root hydropatterning." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/51526/.

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Lateral roots (LR) contribute considerably to the architecture of the root system. The hormone auxin tightly controls the regulation of LR formation in response to environmental signals. For example, roots have the ability to distinguish between wet and dry micro environments in the soil and adapt the positioning of lateral roots accordingly. This concept is referred to as LR hydropatterning and is a novel adaptive mechanism for controlling root branching. When growing vertically down an agar plate, Arabidopsis thaliana roots are also exposed to an asymmetric distribution of water that causes

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3

Brooks, Justin. "A MOLECULAR MECHANISM REGULATING THE TIMING OF CORTICOGENICULATE INNERVATION." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3221.

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Visual system development requires the formation of precise circuitry in the dorsal lateral geniculate nucleus (dLGN) of the thalamus. Although much work has examined the molecular mechanisms by which retinal axons target and form synapses in dLGN, much less is known about the mechanisms that coordinate the formation of non-retinal inputs in dLGN. These non-retinal inputs represent ~90% of the terminals that form in dLGN. Interestingly, recently reports show that the targeting and formation of retinal and non-retinal inputs are temporally orchestrated. dLGN relay neurons are first innervat

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4

Dawson, Lisa Frances. "A novel mechanism regulating DNA-damage repair in Mycobacterium tuberculosis." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444620/.

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The intracellular pathogen Mycobacterium tuberculosis (M. tuberculosis) resides in macrophages and is the causative agent of human tuberculosis. Infected macrophages produce reactive oxygen and nitrogen intermediates, known to damage DNA therefore DNA damage repair is thought to be important in survival of M. tuberculosis in the host. The expression of many bacterial DNA repair genes is often regulated by the SOS response, in which RecA is an integral part however, in M. tuberculosis the majority of genes in the DNA-damage regulon are regulated independently of the RecA/LexA system. In this st

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5

Hussey, George S. "Identification of a Post-Transcriptional Mechanism Regulating Epithelial-Mesenchymal Transition." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1354051158.

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6

Aikawa, Yoshiki. "Structural studies on regulating mechanism of coenzyme A biosynthesis in archaea." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215949.

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7

Tsuchida, Atsushi. "Action Mechanism of Brain-Derived Neurotrophic Factor in Regulating Glucose Metabolism." Kyoto University, 2002. http://hdl.handle.net/2433/149508.

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8

ZALFA, FRANCESCA. "A new mechanism for regulating mRNA translation in the mammalian CNS:." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2006. http://hdl.handle.net/2108/245.

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Abstract tesi PhD Dr. Zalfa Francesca A new mechanism for regulating mRNA translation in the mammalian CNS: a role for the Fragile X Mental Retardation Protein FMRP (Fragile X Mental Retardation Protein) è una proteina che lega gli RNA altamente espressa nel cervello. L’assenza o la mutazione di FMRP causa la sindrome dell’X fragile, una disfunzione dominante legata al cromosoma X e la più frequente causa di ritardo mentale ereditario (con un’incidenza di 1 su 4000 maschi e di 1 su 6000 femmine). Utilizzando il modello murino della sindrome dell’X Fragile (il topo FMR1 knock-out), h

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9

Burton, Paul Bryan James. "An examination of the molecular mechanisms contributing to cardiac myocyte cell cycle withdrawal." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322192.

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10

Alkailani, Maisa. "Factors Regulating Retrotransposon Expression : Uncovering a Novel BRCA1 Related Mechanism in Ovarian Cancer." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42529.

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Retrotransposons constitute about a third of our genome. It is challenging to identify the causes and consequences of retrotransposon expression in human disease due to hundreds of active genomic copies and poor conservation across species. We profiled genomic insertions of retrotransposons in ovarian cancer. RNAs exhibiting Bayesian correlation with retrotransposon RNA were analyzed to identify potential causes and consequences of retrotransposon expression in ovarian and breast cancers. This strategy found divergent inflammatory responses associated with retrotransposon expression in ovarian

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11

Williams, Michael. "Secretin-Modulated Potassium Channel Trafficking as a Novel Mechanism for Regulating Cerebellar Synapses." ScholarWorks @ UVM, 2013. http://scholarworks.uvm.edu/graddis/241.

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The voltage-gated potassium channel Kv1.2 is a critical modulator of neuronal physiology, including dendritic excitability, action potential propagation, and neurotransmitter release. However, mechanisms by which Kv1.2 may be regulated in the brain are poorly understood. In heterologous expression systems Kv1.2 is regulated by endocytosis of the channel from the plasma membrane, and this trafficking can be modulated by adenylate cyclase (AC). The goal of this dissertation was to determine whether AC modulated endocytic trafficking of endogenous Kv1.2 occurred in the mammalian nervous system.

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12

Hida, Yoshifumi. "Studies on the mechanism regulating the formation of adipose tissue by food constituents." Kyoto University, 2000. http://hdl.handle.net/2433/181416.

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13

Pollutri, Daniela <1982&gt. "Drugs down-regulating E2F-1 expression hinders cell proliferation through a p53-indipendent mechanism." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6575/1/Pollutri_Daniela_tesi.pdf.

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E2F-1 is a transcription factor that plays a key role in cell-cycle control at G1/S check-point level by regulating the timely expression of many target genes whose products are required for S phase entry and progression. In mammalian cells, E2F-1 is negatively regulated by hypo-phosphorylated Retinoblastoma protein (pRb) whereas it is protected against degradation by its binding to Mouse Double Minute 2 protein (MDM2). In this study we experimented a drug combination in order to obtain a strong down-regulation of E2F-1 by acting on two different mechanisms of E2F-1 regulation mentioned abov

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14

Pollutri, Daniela <1982&gt. "Drugs down-regulating E2F-1 expression hinders cell proliferation through a p53-indipendent mechanism." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6575/.

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Анотація:

E2F-1 is a transcription factor that plays a key role in cell-cycle control at G1/S check-point level by regulating the timely expression of many target genes whose products are required for S phase entry and progression. In mammalian cells, E2F-1 is negatively regulated by hypo-phosphorylated Retinoblastoma protein (pRb) whereas it is protected against degradation by its binding to Mouse Double Minute 2 protein (MDM2). In this study we experimented a drug combination in order to obtain a strong down-regulation of E2F-1 by acting on two different mechanisms of E2F-1 regulation mentioned abov

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15

Tulsian, Richa. "Circadian Clock as the mechanism of Caloric Restriction in regulating mTOR Signaling and Glucose Homeostasis." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1539971252367088.

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16

Zhang, Hui. "Dipeptidyl Peptidase 9: Novel Natural Substrates, Intracellular Localisation and its Mechanism of Regulating Cell Adhesion." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14274.

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Dipeptidyl Peptidase 9 (DPP9) is intracellular, ubiquitously expressed and influences epidermal growth factor signalling. Mice lacking DPP9 proteolytic activity die as neonates. Super Resolution Microscopy revealed that DPP9-EGFP co-localises with microtubules. A long form of DPP9 was in the nucleus and active there. Cytoplasmic DPP9-short was visualised at the leading edge of migrating cells and co-localised with the focal adhesion proteins integrin-β1 and talin. DPP9 gene silencing or enzyme inhibition reduced cell adhesion and migration, the abundance of integrin-β1 and talin and the phosp

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17

Падалко, Т. М., та А. О. Падалко. "Напрями вдосконалення механізму регулювання банківської системи". Thesis, Українська академія банківської справи Національного банку України, 2009. http://essuir.sumdu.edu.ua/handle/123456789/61899.

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18

Ma, Xin Bo. "Characteristic analysis, regulating mechanism modeling and advanced control on hydraulic adjustable dampers for automotive semi-active suspensions." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3951593.

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19

Stuart, Andrew. "The role of P450RAI in an autoregulatory feedback loop mechanism involved in regulating RA level in MCF-7 and NB4 cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0002/MQ59405.pdf.

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20

Daniels, M. J. "Mechanisms regulating eukaryotic mitosis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598272.

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The fertilised egg gives rise to the entire organism through the coordination of high fidelity chromosome replication and then segregation. When this mechanism is corrupted cells acquire stable genetic mutations that absolve them from the normal proliferative impediments at work to keep the organism healthy. This is the basis of cancer. In order to understand and then rationally treat cancer we must understand the process of cell division. In this thesis I elucidate novel information pertaining to three mechanisms that guide a cell through the process of mitosis. Firstly as cells enter mitosis

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21

Ward, Carol. "Mechanisms regulating granulocyte apoptosis." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/22722.

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Few factors present at inflammatory foci have not been demonstrated to accelerate granulocyte apoptosis; most inhibit the process, adding to the longevity of these cells. The purpose of these studies was to examine the role of different classes of inflammatory mediators in the induction of granulocyte apoptosis and investigate the possible mechanisms involved. We have shown that the majority of pro-inflammatory cytokines inhibit the process of apoptosis in granulocytes. The anti-inflammatory cytokine IL-10 had no effect on granulocyte apoptosis, but in neutrophils, it inhibited the survival ef

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22

Kalaji, Ruba. "Mechanisms regulating keratinocyte morphology." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501083.

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23

White, Andrea Jane. "Mechanisms regulating lymph node organogenesis." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487169.

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The fonnation of organised microenvironments within lymph nodes(LN) occurs during development and is essential to support effective immune responses. Organogenesis ofLNs requires interactions between LTI* expressing mesenchymal stromal organiser cells and LTaJI32 expressing hematopoietic LTi cells. This activates the NF-KB signalling pathway, inducing expression of chemokines and adhesion molecules that are essential for the continued recruitment and retention ofLTi cells, and ultimately the recruitment oflymphocytes to the iLN. However the cellular and molecular mechanisms ofLN development ar

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24

Van, den Bosch Marion T. J. "Signalling mechanisms regulating platelet secretion." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685919.

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Platelets are vital in haemostasis to prevent bleeding after injury. Uncontrolled platelet activation, however, leads to thrombosis. Platelet granule secretion is critical in thrombus formation and, due to the wide variety of granule contents released, also plays a role in many other physiological and pathological processes. The signalling molecule PKC is key in secretion of both dense and a-granules, but the downstream pathways that link it to secretion still need to be defined. A regulator of a-granule release, specifically, is ADP, which acts on the P2Y12 receptor after being secreted by de

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25

Malinverno, M. "MOLECULAR MECHANISMS REGULATING SPINE REMODELLING." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150194.

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N-Cadherin plays an important role during dendrite arborisation, axon guidance and synaptogenesys. In particular, at synaptic sites, it is required for activity-dependent synaptic plasticity and dendritic spine remodeling. Recent studies have shown that N-Cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that modulating ADAM10 localization and activity at synaptic sites regulates its processing of N-Cadherin. This indices modification of dendritic spines morphology and of composition and function of AMPA receptors. In particular, inhibition of ADAM10 synaptic locali

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26

Karamboulas, Konstantina. "Delineating the molecular mechanisms regulating chondrogenesis." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/811.

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Sox9, (SRY-type HMG box), has been shown to play a critical role throughout chondrogenesis. Haploinsufficiency of Sox9 in humans leads to a skeletal malformation syndrome known as campomelic dysplasia. To understand the regulation of Sox9 during chondrogenesis, the developing mouse limb was used to identify and characterize regulatory regions within the Sox9 promoter. Luciferase-based reporter assays in mouse revealed a proximal promoter spanning – 2 kb from the transcriptional start site, while mobility shift assays demonstrated that a CCAAT motif is involved in the transactivation of Sox9

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27

Zhou, Lei. "Molecular mechanisms regulating dendritic spine morphology." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106328.

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In the central nervous system, chemical synapses are highly specialized junctions that are known to be critical for communication between neurons. The ability of synapses to change their physiological and structural properties, known as synaptic plasticity, is important for storing information in neural connections. Dendritic spines are small protrusions on dendrites where the majority of glutamatergic synapses form in the brain. In general, a dendritic spine has an enlarged head region that is connected to the dendritic shaft by a narrow neck. This geometry allows spines to function as indivi

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28

Barnabé-Heider, Fanie. "Molecular mechanisms regulating cortical precursor differentiation." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100317.

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During development of the mammalian cerebral cortex, precursor cells in the ventricular zone sequentially produce neurons and glial cells. This process clearly involves a complex interplay between intrinsic cellular machinery and extrinsic cues. Remarkably, embryonic cortical precursor cells isolated at the onset of neurogenesis, and cultured under serum-free conditions, will mimic the temporal differentiation pattern observed in vivo, producing neurons first, and then glia. In the studies presented here, I have used this system to identify critical components of the intracellular machinery th

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29

Tang, Tina Tze-Tsang. "Molecular mechanisms regulating NMDA receptor trafficking." Thesis, University of Bristol, 2009. http://hdl.handle.net/1983/684cfaf8-a402-4518-b710-ebc237a3e170.

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30

Novak, Stefanie Whalen Mares, and Stefanie Whalen Mares Novak. "Elucidating the Mechanisms Regulating Cardiac Cytoarchitecture." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/624286.

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In striated muscle, contractile activity is dependent on the coordination between the basic contractile unit called the sarcomere and complex cytoskeletal networks. For efficient contractile function, each component is highly regulated to ensure proper expression, assembly and localization within the cell. The molecular mechanisms that govern regulation in muscle cells are still being investigated. In this dissertation, two areas of regulation were investigated: 1) regulation of the heart's conduction system by the RNA-binding protein Fragile X (Chapter 2); and 2) regulation of the sarcomere’s

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31

Obino, Dorian. "Molecular mechanisms regulating B lymphocyte polarization." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB031/document.

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Dans les organes lymphoïdes secondaires, les lymphocytes B acquièrent des antigènes immobilisés à la surface de cellules voisines. L’engagement du BCR (récepteur des cellules B) avec de tels antigènes induit la formation d’une synapse immunologique et la polarisation des lymphocytes B. Cette polarisation inclut le repositionnement du centrosome à la synapse immunologique ainsi que le recrutement et la sécrétion locale des lysosomes qui sont nécessaires à l’extraction, l’apprêtement et la présentation des antigènes sur les molécules du complexe majeur d’histocomptabilité de classe II (CMH-II) a

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32

Benusa, Savannah D. "MECHANISMS REGULATING AXON INITIAL SEGMENT STABILITY." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5357.

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Axon initial segment (AIS) disruption has been described in a number of pathological environments where neuroinflammation is a contributing factor; however, whether this disruption is reversible in unknown. To address the principle of AIS structural recovery, we employed an acute neuroinflammatory model. Acute neuroinflammation induced disruption of AIS structural and functional domains and, importantly, upon resolution of neuroinflammatory conditions, was reversed. Consistent with other studies, we observed a close interaction of microglia with AISs, and utilized this acute neuroinflammatory

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33

Herrmann, Claudia. "Die Huflängenregulation bei im Semireservat gehaltenen Liebenthaler Pferden durch saisonale Einflüsse auf Hornbildung und Hornverlust." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-166200.

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Einleitung Huferkrankungen nehmen einen hohen Patientenanteil in der orthopädischen Pferdepraxis ein. Sie sind häufig begleitet von geringem Hornwachstum und/oder ständigen Tragrandausbrüchen. Hierbei stellt sich die Frage, in wie weit dieses Geschehen durch die jeweilige Pferdehaltung begünstigt wird und wie stark der genetische Einfluss hierauf ist. Vom einzigen rezenten Wildpferd, dem Przewalskipferd, sind Daten zum Hornwachstum und -abrieb mit ausgeprägter Saisonalität bekannt, außerdem existiert bei Haltung im Semireservat ein spezieller Mechanismus des Tragrandausbruches. Diese Faktoren

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34

Schnappauf, Oskar [Verfasser], Andreas [Akademischer Betreuer] Hecht, and Rudolf [Akademischer Betreuer] Grosschedl. "Mechanisms of enhancer regulation." Freiburg : Universität, 2015. http://d-nb.info/1122646836/34.

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35

Kubin, A. M. (Anna-Maria). "Characterization of signaling mechanisms regulating cardiac contractility." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294433.

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Abstract The heart adapts to hemodynamic overload with cardiac hypertrophy. Initially the increase in heart mass normalizes wall stress and permits normal cardiac function. In the long term pathological growth is associated with increased heart size, loss of functional myocytes and fibrotic replacement, heart dilatation and cardiac dysfunction, which can ultimately lead to heart failure. Vasoactive peptides participate in the regulation of cardiac contractility in an auto/paracrine way, but the peptidergic signaling pathways are largely unknown. The present study aimed to characterize the sign

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36

Chiapparo, Giuseppe. "Mechanisms regulating cardiovascular progenitor specification and migration." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/222053.

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During embryonic development and embryonic stem (ES) cell differentiation, the different cardiovascular cell lineages that compose the mature heart arise from different groups of cardiovascular progenitors (CPs), which contribute to the formation of different heart regions. Mesp1 expression is the earliest sign of cardiovascular development. Tracing of the early Mesp1-exressing cells reveals that all cardiovascular cell of the mature heart arise from Mesp1-derived cells. Various functional studies demonstrated that Mesp1 acts as a central regulator of cardiovascular lineage commitment, control

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37

Chopra, Bikramjit. "Mechanisms regulating excitability of primary afferent nociceptors." Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/29933.

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The perception of pain - burning, aching and soreness - acts as a physiological warning that protects us from real or potential injury by employing both behavioural and reflex avoidance responses. Unfortunately, this sensory modality can outlive its usefulness and become chronic and debilitating. Indeed, inflammatory mediators released following tissue trauma can sensitise pain fibres (primary afferent nociceptors) to a diverse range of mechanical, chemical and thermal stimuli. The aim of the present study was to investigate the molecular mechanisms regulating the excitability of primary affer

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38

Mackenzie, Paul James. "Mechanisms regulating the reliability of synaptic transmission." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/NQ46382.pdf.

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39

Scime, Anthony. "Molecular mechanisms regulating the E2F4 transcription factor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0031/NQ66234.pdf.

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40

Tornieri, Karine. "Signaling Mechanisms Regulating Neuronal Growth Cone Dynamics." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_diss/48.

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During the development of the nervous system, neurons migrate to their final location and extend neurites that navigate long distances in the extracellular environment to reach their synaptic targets. The proper functioning of the nervous system depends on correct connectivity, and mistakes in the wiring of the nervous system lead to brain abnormalities and mental illness. Growth cones are motile structures located at the tip of extending neurites that sense and respond to guidance cues encountered along the path toward their targets. Binding of these cues to receptors located on growth cone f

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41

Russell, Matthew Robert Geoffrey. "Mechanisms regulating membrane protein traffic through endosomes." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424910.

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42

La, Pira Lucia. "Post-translational mechanisms regulating Glutathione Peroxidase 4." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424680.

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Glutathione peroxidase 4 (GPx4) is a selenocysteine-containing homolog of the vertebrate glutathione peroxidase family, peculiarly reducing membrane hydroperoxide by glutathione (GSH). GPx4 was first purified in 1982 as a ‘peroxidation inhibiting protein’, and is emerging to date, together with its substrate GSH, as a major determinant in regulating cell balance between proliferation and death. Recently, it emerged that GPx4 inactivation or GSH depletion in cells causes death by a novel subroutine relying on lipid peroxidation, named ferroptosis. Consistently, reverse genetics studies indicate

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43

Dovha, L. "Regulation mechanism of the environmental safety." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/40714.

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The main areas of improvement of the economic regulation mechanism of environmental safety is the modernization of existing regulators, carried out simultaneously with the development and implementation in practice of new market instruments. International experience shows that environmental management system depends on the efficiency of economic mechanism of nature, which is based on a balanced combination of regulators and enforcement of restrictive controls stimulating and compensatory [1].

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44

King, Rosemary. "Cognitive mechanisms underlying emotion regulation." Thesis, University of Leeds, 2008. http://etheses.whiterose.ac.uk/307/.

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Traditional theories of emotion have emphasised the automatic and unconscious nature of emotion generation and hence emotion regulation via antecedent and response focused strategies. Response strategies either inhibit the expression of an emotional response or modulate it via cognitive reappraisal. Antecedent strategies involve avoidance behaviour i. e. avoiding situations in which the emotional response is likely to occur. Recent evidence has now demonstrated, however, that the cognitive and emotional systems are highly interactive and that conscious attention may be necessary to generate em

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45

Donnelly, Shaun Robert. "Mechanisms of annexin gene regulation." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286070.

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46

Zaidi, Mone. "Novel mechanisms of osteoclast regulation." Thesis, University of London, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411434.

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47

Barber, M. A. "Mechanisms of P-Rex1 regulation." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596342.

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First, regulation of its subcellular localisation: the upstream activators of P-Rex1, Gβγs and PI(3,4,5)P<sub>3</sub>, as well as its downstream effector Rac, are all intrinsically associated with the plasma membrane. Yet in resting cells P-Rex1 is mainly cytosolic. Here, it is shown that Gβγ and PI3K together synergistically cause a robust increase in membrane-localised P-Rex1. The isolated DH/PH domains of P-Rex1 are sufficient for synergistic Gβγ- and PI3K-driven membrane localisation. Furthermore, membrane-derived purified P-Rex1 has a higher basal activity than cytosol-derived P-Rex1. Sec

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48

McCarthy, Michael Thomas. "Mechanisms of NKG2D ligand regulation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:69de3276-0b1e-4174-9309-988242468682.

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Background: The NKG2D ligands are a set of cell surface proteins, the expression of which can make cells susceptible to immunity mediated by NKG2D receptor expressing cells, which include NK cells, CD8<sup>+</sup> αβ T cells and γδ T cells. The NKG2D ligands are known to be expressed in distinct settings, including viral infection, cancer, T cell activation, and cellular proliferation, settings also tightly associated with Warburg metabolism. The molecular events which determine NKG2D ligand expression status are unknown. Aims: We aim to enhance understanding of the deterministic molecular eve

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49

Mandel, Elizabeth Marie Conlon Frank L. "Molecular mechanisms of Tbx20 regulation." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2290.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Jun. 26, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biology Molecular, Cellular and Developmental Biology." Discipline: Biology; Department/School: Biology.

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50

Gaitonde, Supriya Vishwaraj. "Mechanisms involved in p53 regulation." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/298798.

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Inactivation of the tumor suppressor protein p53 is a very important and common step in the process of carcinogenesis. The overall purpose of this project was to gain a better understanding of the mechanisms involved in the regulation of p53 function. To gain insight into these mechanisms, we chemically mutagenized A1-5 cells expressing high levels of temperature sensitive p53 val135 (tsp53) and selected for clones that were capable of growth at the permissive temperature for p53 activation. The clones generated, called ALTR (for A&barbelow;1-5 L&barbelow;ow T&barbelow;emperature R&barbelow;es

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