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Статті в журналах з теми "Memantine hydrochloride"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Witt, Andrea, Nancy Macdonald, and Peter Kirkpatrick. "Memantine hydrochloride." Nature Reviews Drug Discovery 3, no. 2 (2004): 109–10. http://dx.doi.org/10.1038/nrd1311.

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2

Narola, Bhavil, A. S. Singh, P. Rita Santhakumar, and T. G. Chandrashekhar. "A Validated Stability-indicating Reverse Phase HPLC Assay Method for the Determination of Memantine Hydrochloride Drug Substance with UV-Detection Using Precolumn Derivatization Technique." Analytical Chemistry Insights 5 (January 2010): ACI.S3936. http://dx.doi.org/10.4137/aci.s3936.

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This present paper deals with the development and validation of a stability indicating high performance liquid chromatographic method for the quantitative determination of Memantine hydrochloride. Memantine hydrochloride was derivatized with 0.015 M 9-fluorenylmethyl chloroformate (FMOC) and 0.5 M borate buffer solution by keeping it at room temperature for about 20 minutes and the chromatographic separation achieved by injecting 10 μL of the derivatized mixture into a Waters HPLC system with photodiode array detector using a kromasil C18 column (150 × 4.6 mm), 5 μ, The mobile phase consisting

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3

Yegorova, A., Yu Skrypynets, I. Leonenko, G. Maltsev, S. Kashutskуy, and O. Voitiuk. "Development and Validation of HPLC-MS Method of Determination of Memantine Hydrochloride for Study of Dissolution Profiles." Methods and Objects of Chemical Analysis 16, no. 2 (2021): 71–80. http://dx.doi.org/10.17721/moca.2021.71-80.

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A method for quantitative determination of memantine hydrochloride by HPLC with mass spectrometric detection (HPLC-MS), suitable for the study of dissolution profiles of tablets "Mematon IС" was developed. Chromatographic determination was performed using a mobile phase of methanol - 0.1% (v/v) aqueous solution of formic acid (55:45) on a column of Zorbax Eclipse Plus C18 size 10 cm Ч 4.6 mm (3.5 μm) at a flow rate of 1 ml/min. The linearity interval in the appropriate dissolution media is 35 - 150 % of the normalized content of memantine hydrochloride in the tablet. The method is validated on

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4

Nguyễn, Thị Hồng Thắm, Đinh Châu Phan, Thị Hồng Thanh Nguyễn, Thị Xuân Thu Ngô, Thị Thủy Đặng, and Bình Dương Vũ. "SYNTHESIS OF MEMANTINE HYDROCHLORIDE BY DIRECT AMINOATION OF 1-BROMO-3,5-DIMETHYLADAMANTANE WITH." VietNam Military Medical Unisversity 47, no. 9 (2022): 140–48. http://dx.doi.org/10.56535/jmpm.v47i9.214.

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Objectives: To optimize the synthesis process of memantine hydrochloride by direct aminoation of 1-bromo-3,5-dimethyladamantane with urea. Materials and methods: Using the basic chemical reactions to optimize the reaction conditions. Results: The optimal conditions of the memantine hydrochloride synthesis process include: The reaction solution was diphenyl ether; the reaction temperature was 170oC within 4 hours (in the first step) and 100oC within 2 hours (in the second step); the molar ration of 1-bromo-3,5-dimethyladmantane: urea: diphenyl ether was 1:3:2.5; the duration of the reaction was

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5

Ivleva, Elena A., and Yuri N. Klimochkin. "Convenient Synthesis of Memantine Hydrochloride." Organic Preparations and Procedures International 49, no. 2 (2017): 155–62. http://dx.doi.org/10.1080/00304948.2017.1291004.

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6

Zhao, Jian, Xi Li, Xuelian Jia, and Ganke Gao. "Clinical Study on the Treatment of Senile Alzheimer’s Dementia with Sodium Oligomannate Combined with Memantine Hydrochloride." Journal of Clinical and Nursing Research 8, no. 10 (2024): 208–17. http://dx.doi.org/10.26689/jcnr.v8i10.8701.

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Objective: To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia. Methods: Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects. The patients were divided into two groups based on different treatment methods: the control group (treated with memantine hydrochloride, 34 cases) and the treatment group (treated with sodium oligomannate + memantine hydrochloride, 34 c

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7

Mobius, H. J., A. Stoffler, and S. M. Graham. "Memantine hydrochloride: Pharmacological and clinical profile." Drugs of Today 40, no. 8 (2004): 685. http://dx.doi.org/10.1358/dot.2004.40.8.850471.

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8

Duong Vu, Binh, Ngoc Minh Ho Ba, Hung Van Tran, and Dinh Chau Phan. "An Improved Synthesis of Memantine Hydrochloride." Organic Preparations and Procedures International 52, no. 5 (2020): 463–67. http://dx.doi.org/10.1080/00304948.2020.1785807.

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9

Dubey, Sunil K., Anil Patni, Arshad Khuroo, et al. "A Quantitative Analysis of Memantine in Human Plasma Using Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry." E-Journal of Chemistry 6, no. 4 (2009): 1063–70. http://dx.doi.org/10.1155/2009/748492.

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The aim of this study is to compare the single-dose oral bioavailability of memantine hydrochloride 10 mg tablets of Ranbaxy Laboratories Limited, with NAMENDA™ tablets (containing memantine hydrochloride 10 mg) of Forest Pharmaceuticals Inc. in healthy, adult, human subjects under fasting condition. The study was carried out as 2-way crossover design on 8 subjects in fasting and fed conditions. The plasma samples were obtained over a 72 h post dose in each period. Plasma memantine samples were analyzed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with positive ion e

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10

Michail, Karim, Hoda Daabees, Youssef Beltagy, Magdy Abd Elkhalek, and Mona Khamis. "High-Performance Liquid Chromatographic Determination of Memantine in Human Urine Following Solid-Phase Extraction and Precolumn Derivatization." Journal of AOAC INTERNATIONAL 96, no. 6 (2013): 1302–7. http://dx.doi.org/10.5740/jaoacint.11-080.

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Abstract A validated HPLC-UV method is presented for the quantification of urinary memantine hydrochloride, a novel medication approved to treat moderate and advanced cases of Alzheimer's disease. The drug and amantadine hydrochloride, the internal standard, were extracted from human urine using SPE. The extract was then buffered and derivatized at room temperature using o-phthalaldehyde in the presence of N-acetyl-L-cyteine. Chromatographic separation of the formed derivatives was achieved on a C18 column using methanol–water mobile phase adjusted to pH 7 and pumped isocratically at 1 mL/min.

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11

Asra, Ali Bahazeq, Noor Syeda Wasfiya, Fatima Isba Nashra, Muzaffar-Ur-Rehman MD., and Amatul Baqi Uzma. "Assay of Memantine Hydrochloride by UV Spectrophotometer." INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH 10, no. 1 (2019): 27–30. https://doi.org/10.5281/zenodo.2589919.

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Memantine hydrochloride is a class of N-Methyl-D-Aspartase receptor antagonist used in the treatment of Alzheimer’s disease. The main aim of the present study was to develop a method to determine Memantine hydrochloride in tablet formulation which is simple, sensitive, precise and economical as per ICH guidelines. The method was validated at λ <sub>max</sub> of 254nm. Beer-Lambert’s was obeyed between the concentration ranges of 0.2-0.6µg/ml. A good linear relationship with correlation co-efficient of 0.998 was obtained and the LOD and LOQ values were 0.48µg/ml a

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12

AK, Hakan, Iskender Samet Daltaban, and Sevilay Vural. "Acute Phase Effect of Memantine Hydrochloride in Experimental Peripheral Nerve Injury." Indian Journal of Neurosurgery 08, no. 02 (2019): 113–18. http://dx.doi.org/10.1055/s-0039-1695668.

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Abstract Aim In this experimental study, we aimed to investigate possible healing effects of memantine hydrochloride, an N-methyl-d-aspartate (NMDA) antagonist, with clinical, biochemical, and histopathologic methods on acute peripheral nerve injury (PNI). Material and Method Forty-eight adult Wistar albino rats were divided into four groups (n = 12). The groups were arranged as sham-operated group (group 1), acute compression model group (group 2), trauma + low-dose memantine group (group 3), and trauma + high-dose memantine group (group 4). Memantine was administered intraperitoneally for 7

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13

Tham Nguyen, Thi Hong, Viet Duc Le, Sy Thinh Ngo, Thi Hong Thanh Nguyen, Dinh Chau Phan, and Binh Duong Vu. "Two Step Cost-Saving Process for Industrial Scale Production of 1-Amino-3,5-dimethyladamantane Hydrochloride (An Anti-Alzheimer’s Drug)." Asian Journal of Chemistry 34, no. 2 (2022): 251–55. http://dx.doi.org/10.14233/ajchem.2022.23447.

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This work presents a predominant cost-saving process for the industrial scale synthesis of memantine hydrochloride (1) from 1,3-dimethyladamantane (2) by a two-step method in which both steps were carried out in one-pot. The conversion of 2 to N-(3,5-dimethyladamantane-1-yl)acetylamide (3) was synthesized first in mixture of sulfuric acid 96-98% and nitric acid 64-65% at 25 ºC for 2.5 h and then in acetonitrile at 40 ºC for 3.5 h as a key step. The yield of this process reached to 98%. Next, the deacetylation of 3 with potasium hydroxide in mixture of water-ethylene glycol at 140 ºC for 15 h t

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14

Wang, Qi, Wenqi Wu, Yue He, Qiuyue Zheng, and Ming Yu. "Efficacy of Sodium Oligomannate Capsules Combined with Memantine Hydrochloride and Donepezil Hydrochloride in Treating Moderate Alzheimer’s Disease." Journal of Clinical and Nursing Research 9, no. 1 (2025): 19–26. https://doi.org/10.26689/jcnr.v9i1.9493.

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Objective: To explore the clinical efficacy of sodium oligomannate capsules combined with memantine hydrochloride and donepezil hydrochloride in the treatment of moderate Alzheimer’s disease (AD) and analyze its impact on cognitive function. Methods: Eighty patients with moderate AD admitted to the neurology outpatient clinic of our hospital from June 2021 to December 2022 were selected as the study subjects and randomly divided into a study group and a control group, each with 40 patients. The control group was treated with oral memantine hydrochloride and donepezil hydrochloride, while the s

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15

Tukaram, B. Sawant* Dhananjay V. Mane. "TO DEVELOP HPLC METHOD FOR THE ASSAY OF MEMANTINE HYDROCHLORIDE TABLETS USING REFRACTIVE INDEX (RI) DETECTOR." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4391–97. https://doi.org/10.5281/zenodo.1064353.

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Objective: To develop and validate a chromatographic method to determine the amount of drug (assay) in the tablets of memantine hydrochloride (MEM) using high performance liquid chromatography with refractive index (RI) detector. Methods: The chromatographic separation was achieved on C18 (250 × 4.5 mm, 5μ) column using isocratic mobile phase comprises of buffer (pH-6.0): Methanol (45:55 v/v) pumped at a flow rate of 1.0 ml/min. The detection of effluent was monitored using RI detector. Conclusion: The method was found to be simple, commercial, precise, accurate and robust which can b

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16

Mohamed, Sharmarke, Durga Prasad Karothu, and Panče Naumov. "Using crystal structure prediction to rationalize the hydration propensities of substituted adamantane hydrochloride salts." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 72, no. 4 (2016): 551–61. http://dx.doi.org/10.1107/s2052520616006326.

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The crystal energy landscapes of the salts of two rigid pharmaceutically active molecules reveal that the experimental structure of amantadine hydrochloride is the most stable structure with the majority of low-energy structures adopting a chain hydrogen-bond motif and packings that do not have solvent accessible voids. By contrast, memantine hydrochloride which differs in the substitution of two methyl groups on the adamantane ring has a crystal energy landscape where all structures within 10 kJ mol−1of the global minimum have solvent-accessible voids ranging from 3 to 14% of the unit-cell vo

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17

del Rio-Sancho, Sergio, César E. Serna-Jiménez, M. Aracely Calatayud-Pascual, et al. "High-Performance Liquid Chromatographic Ultraviolet Determination of Memantine Hydrochloride afterIn VitroTransdermal Diffusion Studies." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/502652.

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The purpose of the present work was to validate an accurate and precise high-performance liquid chromatography (HPLC) method involving ultraviolet detection for the quantitative analysis of memantine hydrochloride. In order to analyze a molecule with no chromophoric groups that could be detected by a UV/visible detector, it was necessary to extract the drug and to perform a dansylation reaction that enabled the UV/visible detection of the derivatized molecule. Separation was carried out with a 150 mm Kromasil C18 column at room temperature. The detection response, at 218 nm, was found to be li

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18

Istifo, N. N. H., M. A. J. Al-Zobaidy, and K. S. Abass. "Long term effect of fluoxetine and memantine on biochemical markers of Alzheimer’s disease in scopolamine-induced mice." Regulatory Mechanisms in Biosystems 15, no. 2 (2023): 226–29. http://dx.doi.org/10.15421/022433.

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Alzheimer’s disease is a chronic neurological illness that causes considerable cognitive impairment. However, there is no effective treatment for this disease. Therefore, the current study aimed at investigating the long-term effects of fluoxetine and memantine on biochemical markers of Alzheimer’s disease in scopolamine-induced mice. In this study, adult female mice were divided into four equal groups; normal control received distilled water only, the untreated Alzheimer’s disease group received scopolamine intraperitoneal IP/SCM for 14 days, following which distilled water was given for six

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19

Biederman, Joseph, Ronna Fried, Laura Tarko, et al. "Memantine in the Treatment of Executive Function Deficits in Adults With ADHD." Journal of Attention Disorders 21, no. 4 (2016): 343–52. http://dx.doi.org/10.1177/1087054714538656.

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Objective: To evaluate the efficacy and safety of memantine hydrochloride as an adjunct to stimulant pharmacotherapy for treating executive function deficits (EFDs) in adults with ADHD. Method: This was a 12-week, double-blind, placebo-controlled, randomized clinical trial of memantine added to open-label treatment with stimulant medication. Because of the small sample size, we considered a standardized mean difference (equivalent to effect size) of ≥0.5 and odds ratios ≥2 as indicators of trend improvements. Results: Twelve participants received memantine and 14 received a placebo. Trend impr

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20

Yang, Yu, Lifei Xing, Hongliang Yan, et al. "Effect of Memantine Hydrochloride on Homocysteine Level and Cognitive Function in Diabetic Vascular Dementia Model Mice." Journal of Biomaterials and Tissue Engineering 11, no. 5 (2021): 872–78. http://dx.doi.org/10.1166/jbt.2021.2643.

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Increased Hcy has a toxic effect on nerve cells and can cause hippocampal death and directly damage the body’s cognitive function and memory ability, leading to the occurrence of vascular dementia. Hcy predicts vascular disease and might be a basis for clinical judgment. This article provides a new basis for the prevention and treatment of this disease by exploring the mechanism of action of memantine hydrochloride in diabetic vascular dementia. After grouping, mice walked through the Morris water maze to record the escape latency, and measured the Hcy level of the mice by high performance liq

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21

Holland, Peter J., Ruth M. Tappen, David O. Newman, Katherine C. Freeman-Costin, and Lori J. Fisher. "Effect of Memantine on Prolonging Safe Driving in Early AD: a Pilot Study." Canadian Geriatrics Journal 24, no. 4 (2021): 292–96. http://dx.doi.org/10.5770/cgj.24.540.

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Background To determine the feasibility of conducting an RCT on the potential effectiveness of memantine hydrochloride in prolonging safe driving in mild AD. Methods A placebo-controlled, double blind randomized trial was conducted. Forty-three individuals ≥60 with mild AD met screening criteria and were randomized. Driving ability was measured by a standardized on-road driving test. Outcomes were driving capacity at 6 and 12 months and completion of the 12-month intervention. Results Of 43 participants randomized, 59% of the memantine group and 52% of the placebo group completed the on-road t

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22

Nunes, Débora, Tânia G. Tavares, Frenacisco Xavier Malcata, Joana A. Loureiro, and Maria Carmo Pereira. "Development and Validation of a Simple UV–HPLC Method to Quantify the Memantine Drug Used in Alzheimer’s Treatment." Pharmaceuticals 17, no. 9 (2024): 1162. http://dx.doi.org/10.3390/ph17091162.

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Memantine, a non-competitive NMDA receptor antagonist, is used to treat Alzheimer’s disease. Therefore, loading memantine in nanoparticles (NPs) could be an essential tool to improve the treatment effectiveness while reducing drug toxicity. Even though some approaches have been described to quantify memantine, none reported optimized methods using high-performance liquid chromatography resorting to ultraviolet detection (UV–HPLC) to determine encapsulation in NPs. The present research developed a HPLC method using pre-column derivatization for quantitatively analyzing memantine hydrochloride i

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23

ZHU, LeiLei, Chen LI, YiFan ZHANG, DaFang ZHONG, Zhen LI, and Jian JIANG. "Bioequivalence of memantine hydrochloride tablets in healthy volunteers." Pharmaceutical Care and Research 15, no. 6 (2015): 432–35. http://dx.doi.org/10.5428/pcar20150611.

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24

Peng, Dantao, Xinrui Yuan, and Rui Zhu. "Memantine hydrochloride in the treatment of dementia subtypes." Journal of Clinical Neuroscience 20, no. 11 (2013): 1482–85. http://dx.doi.org/10.1016/j.jocn.2013.02.041.

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25

Jadhav, Sanjay A., Shashikant B. Landge, Navanath C. Niphade, Saroj R. Bembalkar, and Vijayavitthal T. Mathad. "Development and Validation of Stability-Indicating GC-FID Method for the Quantitation of Memantine Hydrochloride and Its Nonchromophoric Impurities in Bulk and Pharmaceutical Dosages." Chromatography Research International 2012 (June 10, 2012): 1–10. http://dx.doi.org/10.1155/2012/806068.

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A stability-indicating method has been developed and validated for the quantitative determination of memantine hydrochloride and its nonchromophoric impurities in drug substance and drug product using gas chromatography coupled with flame ionization detector (GC-FID). The stability-indicating nature of the method has been proved by establishing peak purity and confirming the mass balance of all samples by subjecting them to stress conditions like hydrolysis, oxidation, photolysis, and thermal degradation studies. The chromatographic separation was performed on a fused silica capillary (HP-5, 3

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26

Kurz, Alexander, and Timo Grimmer. "Efficacy of memantine hydrochloride once-daily in Alzheimer’s disease." Expert Opinion on Pharmacotherapy 15, no. 13 (2014): 1955–60. http://dx.doi.org/10.1517/14656566.2014.945907.

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27

Reddy, Jambula Mukunda, Ganji Prasad, Veeramalla Raju, Mylavarapu Ravikumar, Vurumidi Himabindu, and Ghanta Mahesh Reddy. "An Improved Synthesis of Memantine Hydrochloride: Anti-Alzheimer's Drug†." Organic Process Research & Development 11, no. 2 (2007): 268–69. http://dx.doi.org/10.1021/op060246+.

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28

Baginskas, Armantas, Antanas Kuras, and Artūras Grigaliūnas. "Inhibition of Dendritic L-Type Calcium Current by Memantine in Frog Tectum." Medicina 49, no. 9 (2013): 64. http://dx.doi.org/10.3390/medicina49090064.

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The aim of the study was to explore the effects of memantine on responses elicited in the frog tectum by the bursts of spikes of moderate strength of a single retina ganglion cell and to gain an insight about the effect of memantine on the L-type Ca2+ current. Material and Methods. The experiments were performed in vivo on adult frogs (Rana temporaria). An individual retina ganglion cell (or its retinotectal fiber) was stimulated by current pulses delivered through a multichannel stimulating electrode positioned on the retina. Responses to the discharge of a single retinal ganglion cell were r

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29

Almahozi, Ahmad, Mohamed Radhi, Suja Alzayer, and Amer Kamal. "Effects of Memantine in a Mouse Model of Postoperative Cognitive Dysfunction." Behavioral Sciences 9, no. 3 (2019): 24. http://dx.doi.org/10.3390/bs9030024.

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Persistent impairment in cognitive functioning postoperatively is reported by clinical and animal studies, and is labeled as postoperative cognitive dysfunction (POCD). Evidence points to an exaggerated neuroinflammatory response resulting from peripheral systemic inflammation after surgery, with subsequent cytokine-induced glutamatergic excitotoxicity and synaptic impairment. These immunological changes, among many others, are also observed in Alzheimer’s disease. Memantine is an N-methyl-D-aspartate receptor (NMDAR) antagonist commonly used to treat Alzheimer’s disease. Surprisingly, little

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30

Anees, Ayesha, Asra Ali Bahazeq, Muzaffar-Ur Rehman, Syed Akbar, and Juveria Mehveen. "Development and Validation of Memantine Hydrochloride by RP-HPLC Method." Asian Journal of Pharmaceutical Research 9, no. 2 (2019): 69. http://dx.doi.org/10.5958/2231-5691.2019.00011.x.

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31

Madhra, Mukesh K., Mukesh Sharma, and C. H. Khanduri. "New Synthetic Approach to Memantine Hydrochloride starting from 1,3-Dimethyl-adamantane." Organic Process Research & Development 11, no. 5 (2007): 922–23. http://dx.doi.org/10.1021/op700138p.

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Madhra, Mukesh K., Mukesh Sharma, and C. H. Khanduri. "New Synthetic Approach to Memantine Hydrochloride Starting from 1,3-Dimethyl-adamantane." Organic Process Research & Development 12, no. 1 (2008): 126. http://dx.doi.org/10.1021/op700269v.

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33

Salih, Nadia Abdulkareem, and Banan Khalid Al-Baggou. "Effect of memantine hydrochloride on cisplatin-induced neurobehavioral toxicity in mice." Acta Neurologica Belgica 120, no. 1 (2019): 71–82. http://dx.doi.org/10.1007/s13760-019-01161-z.

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34

Merey, H. A., M. I. Helmy, S. M. Tawakkol, S. S. Toubar, and M. S. Risk. "Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate." Portugaliae Electrochimica Acta 30, no. 1 (2012): 31–43. http://dx.doi.org/10.4152/pea.201201031.

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35

Saidkhodjaeva, Saida N., Yakutkhon N. Madjidova, and Каhramon H. Yuldashev. "Modern approach to neurorehabilitation of children with hiv-encephalopathy." Russian Journal of Physiotherapy, Balneology and Rehabilitation 19, no. 4 (2020): 220–26. http://dx.doi.org/10.17816/1681-3456-2020-19-4-3.

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Background. Currently, there is no standardized and evidence-based medicine specific therapy for HIV-associated neurocognitive disorders. The aim of the study was to evaluate the effectiveness of various neurorehabilitation programs, including the use of memantine hydrochloride and the virtual reality feedback method (NIRVANA) in children with HIV encephalopathy (HIVE) in the aspect of neurocognitive status. Material and methods. The study included 260 children with HIV-positive status and receiving highly active antiretroviral therapy (НAART) according to an individually selected

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Zung, Stevin Parreira, Thais Cuperman-Pohl, Douglas Costa Morais, Rosyanne Michele Marques de Oliveira, and Edson Antonio Bernes. "[P4-205]: FIXED-DOSE COMBINATION OF DONEPEZIL HYDROCHLORIDE AND MEMANTINE HYDROCHLORIDE FOR TREATMENT OF MODERATE TO SEVERE ALZHEIMER'S DISEASE." Alzheimer's & Dementia 13, no. 7S_Part_28 (2017): P1343—P1345. http://dx.doi.org/10.1016/j.jalz.2017.06.2073.

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El Nashar, Rasha M., Aliaa S. M. El-Tantawy, and Saad S. M. Hassan. "Potentiometric Membrane Sensors for the Selective Determination of Memantine Hydrochloride in Pharmaceutical Preparations." International Journal of Electrochemical Science 7, no. 11 (2012): 10802–17. http://dx.doi.org/10.1016/s1452-3981(23)16903-3.

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38

Varu, H. L., N. P. Kapuriya, J. J. Bhalodia, A. H. Bapodra, and M. A. Ambasana. "Kinetic Spectrophotometric Determination of Memantine Hydrochloride Based on the Formation of Its Dinitrochlorobenzene Adduct." Journal of Analytical Chemistry 79, no. 10 (2024): 1431–38. http://dx.doi.org/10.1134/s1061934824700813.

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39

Alarfaj, Nawal A., and Maha F. El-Tohamy. "Conventional and Modified Nano Carbon Paste Sensors for Determination of Alzheimer's Drug Memantine Hydrochloride." Sensor Letters 11, no. 10 (2013): 1968–77. http://dx.doi.org/10.1166/sl.2013.3043.

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40

Vu, Binh Duong, Ngoc Minh Ho Ba, Van Hien Pham, and Dinh Chau Phan. "Simple Two-step Procedure for the Synthesis of Memantine Hydrochloride from 1,3-Dimethyl-adamantane." ACS Omega 5, no. 26 (2020): 16085–88. http://dx.doi.org/10.1021/acsomega.0c01589.

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41

Mateescu, Mădălina, Mihaela Budiul, Paul Albu, Gabriela Vlase, and Titus Vlase. "Thermal behavior and kinetic study of degradation for adamantan-2-one versus memantine hydrochloride." Journal of Thermal Analysis and Calorimetry 130, no. 1 (2017): 391–96. http://dx.doi.org/10.1007/s10973-017-6443-9.

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42

Katunina, E. A., Yu N. Bezdolnyi, and N. N. Shipilova. "Possibilities of using amantadines in the setting of the novel coronavirus infection in patients with Parkinson's disease." Neurology, Neuropsychiatry, Psychosomatics 13, no. 6 (2021): 67–72. http://dx.doi.org/10.14412/2074-2711-2021-6-67-72.

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Анотація:

The novel coronavirus infection pandemic prompted not only the development of vaccines, but also the study of the effectiveness of already known drugs with antiviral activity. These drugs include adamantanes.Objective: to assess possible mechanisms of antiviral action of amantadine and memantine.Patients and methods. The study included 75 patients with Parkinson's disease (PD): 49 (65.3%) women and 26 (34.7%) men. The age of the patients ranged from 37 to 88 years (mean age: 65±7 years). The duration of the disease varied from 1 to 25 years (mean 12±7 years). Among the monitored PD patients, 2

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43

Omara, Hany A. "Spectrophotometric Determination of Alzheimer’s Drug, Memantine Hydrochloride in Biological Samples Using Ninhydrin and Ferric Chloride." IOSR Journal of Applied Chemistry 10, no. 2 (2017): 52–59. http://dx.doi.org/10.9790/5736-1002015259.

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Hardik L. Varu, Naval P. Kapuriya, Jasmin J. Bhalodia, Rashmi B. Patel, Atul H. Bapodra, and Mrunal A. Ambasana. "An Expeditious Spectrophotometric Estimation of Memantine Hydrochloride by Facile Derivatization Using N,N-Dimethyl Aniline." Journal of Analytical Chemistry 77, no. 11 (2022): 1433–39. http://dx.doi.org/10.1134/s1061934822110144.

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45

Xie, Mei-Fen, Wei Zhou, Xin-Yi Tong, et al. "High-performance liquid chromatographic determination of memantine hydrochloride in rat plasma using sensitive fluorometric derivatization." Journal of Separation Science 34, no. 3 (2011): 241–46. http://dx.doi.org/10.1002/jssc.201000579.

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46

Puranik, Nidhi, and Minseok Song. "Therapeutic Role of Heterocyclic Compounds in Neurodegenerative Diseases: Insights from Alzheimer’s and Parkinson’s Diseases." Neurology International 17, no. 2 (2025): 26. https://doi.org/10.3390/neurolint17020026.

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Alzheimer’s and Parkinson’s are the most common neurodegenerative diseases (NDDs). The development of aberrant protein aggregates and the progressive and permanent loss of neurons are the major characteristic features of these disorders. Although the precise mechanisms causing Alzheimer’s disease (AD) and Parkinson’s disease (PD) are still unknown, there is a wealth of evidence suggesting that misfolded proteins, accumulation of misfolded proteins, dysfunction of neuroreceptors and mitochondria, dysregulation of enzymes, and the release of neurotransmitters significantly influence the pathophy

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You, Feng-Ling, Gao-Fu Xia, and Jing Cai. "Behavioural Variant Frontotemporal Dementia due to CCNF Gene Mutation: A Case Report." Current Alzheimer Research 20, no. 5 (2023): 341–48. http://dx.doi.org/10.2174/1567205020666230811092906.

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Background: Frontal, temporal lobe dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative diseases. Studies have found that CCNF mutations have been found in patients with familial and sporadic ALS and FTD. Behavioural variant frontotemporal dementia (bvFTD) is a clinical syndrome characterized by progressive deterioration of personality, social behaviour, and cognitive function, which is most closely related to genetic factors. As the early symptoms of bvFTD are highly heterogeneous, the condition is often misdiagnosed as Alzheimer's disease or psychiatric disorder

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Dr., Subhasri Mohapatra. "Reversible Cholinesterase Inhibitor Loaed Chitosan Based Nanoparticle." INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND BIO-MEDICAL SCIENCE 03, no. 03 (2023): 130–36. https://doi.org/10.5281/zenodo.7759751.

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Memantine hydrochloride is a is a reversible cholinesterase inhibitor used in the treatment of Alzheimer’s disease, low-moderate affinity, uncompetitive n-methyl-d-aspartate (NMDA) receptor antagonist, with strong voltage dependency and rapid blocking/unblocking kineticsThe present study was explore the potential of mamentine loaded nanoparticle.with varying quantity of chitosan byionotropic gelation method.The effect of chitosan quantity on the particle size was studied by varying stirring time and stirring speed. The particle morphology can be modulated by selecting the agitation speed

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Salih, Nadia Abdulkareem, and Banan Khalid AL-Baggou. "Effect of Memantine Hydrochloride on Cisplatin-induced Toxicity with Special Reference to Renal Alterations in Mice." International Journal of Pharmacology 15, no. 2 (2019): 189–99. http://dx.doi.org/10.3923/ijp.2019.189.199.

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Vu, Binh Duong, Ngoc Minh Ho Ba, Van Hien Pham, and Dinh Chau Phan. "Correction to “Simple Two-step Procedure for the Synthesis of Memantine Hydrochloride from 1,3-Dimethyl-adamantane”." ACS Omega 5, no. 40 (2020): 26295. http://dx.doi.org/10.1021/acsomega.0c04305.

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