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Готові списки джерел за темами / Mr 2200 / Статті в журналах

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Статті в журналах з теми "Mr 2200"

Автор: Grafiati

Опубліковано: 25 липня 2024

Оновлено: 31 липня 2025

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1

Suszter, Tamás. "A helyi polgárőrség szerepe a rendezvények biztonságának szavatolásában." Magyar Rendészet 24, no. 1 (2024): 117–36. http://dx.doi.org/10.32577/mr.2024.1.8.

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Анотація:

Napjainkra a rendészet mint állami monopólium paradigma megtörésével a rendfenntartás szükségszerű pluralizálódását, a magánbiztonság és a polgári rendfenntartás előtérbe kerülését, az állami rendészet egyeduralmának megtörését figyelhetjük meg.Hazánk 64 000 fős polgárőrsége 2200 szervezetbe tömörülve, a rendőrség stratégiai partnereként a helyi önkormányzatokkal együttműködve végzi bűnmegelőzési tevékenységét, amelynek egyik szembetűnő megvalósulása a hazai fesztiválturizmus biztonságának, azaz a rendezvénybiztosítások rendészettudományi aspektusainak elemzésével jeleníthető meg.Tanulmányomba

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2

Melis, Eszter. "Átmenet a felnőttkorba: A gyermekek helyzete a középső bronzkorban Magyarország nyugati területein." Magyar Régészet 12, no. 3 (2023): 14–26. http://dx.doi.org/10.36245/mr.2023.3.2.

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Az utóbbi néhány évtizedben került előtérbe a gyermekek helyzetének és szerepének vizsgálata a különböző történelmi és történelem előtti korokban. A sajnálatos módon gyermekkorukban elhunytak sírjai az egyik leggazdagabb és legfontosabb forrásanyagot jelentik a téma őskori kutatásához, amely a modern természettudományos vizsgálatoknak köszönhetően nemcsak a fiatalon elhunytak betegségeiről vagy neméről, hanem életmódjáról (pl. táplálkozásáról) is információval szolgálhat. Nem szabad azonban elfeledkeznünk arról, hogy a gyermekek eltemetésének módja, mellékleteik elsősorban a felnőttek közösség

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3

Kirkness, E. F., та A. J. Turner. "The γ-aminobutyrate/benzodiazepine receptor from pig brain. Purification and characterization of the receptor complex from cerebral cortex and cerebellum". Biochemical Journal 233, № 1 (1986): 265–70. http://dx.doi.org/10.1042/bj2330265.

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The gamma-aminobutyrate/benzodiazepine-receptor complex has been purified from a Triton X-100 extract of crude synaptic membranes from pig cerebral cortex and cerebellum by a combination of affinity and ion-exchange chromatography. [3H]Flunitrazepam binding activity was purified 2200-fold from cortex with an overall yield of 2%. The dissociation constants for the binding of [3H]muscimol and [3H]flunitrazepam to the receptor complex were 14 +/- 3 nM and 14 +/- 2 nM respectively. The ratio of [3H]muscimol to [3H]flunitrazepam binding sites was in the range 2.2-2.8. There appeared to be no select

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4

Mattsson, Cecilia, Rebecca M. Reynolds, Kotryna Simonyte, Tommy Olsson, and Brian R. Walker. "Combined Receptor Antagonist Stimulation of the Hypothalamic-Pituitary-Adrenal Axis Test Identifies Impaired Negative Feedback Sensitivity to Cortisol in Obese Men." Journal of Clinical Endocrinology & Metabolism 94, no. 4 (2009): 1347–52. http://dx.doi.org/10.1210/jc.2008-2054.

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Abstract Context: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation may underlie disorders including obesity, depression, cognitive decline, and the metabolic syndrome. Conventional tests of HPA axis negative feedback rely on glucocorticoid receptor (GR) agonists such as dexamethasone but do not test feedback by endogenous cortisol, potentially mediated by both GR and mineralocorticoid receptors (MR). Objective: The objective of the study was to use a combination of GR (RU38486, mifepristone) and MR (spironolactone) antagonists to explore the poorly understood activation of the HPA axis

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5

Choy, Francis Y. M., and Mary Woo. "Purification and the effect of peptide N-glycosidase F on lysosomal membrane-bound glucocerebrosidase from human cultured fibroblasts." Biochemistry and Cell Biology 69, no. 8 (1991): 551–56. http://dx.doi.org/10.1139/o91-081.

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Glucocerebrosidase was purified from human cultured dermal fibroblasts more than 2200-fold to apparent homogeneity using high performance Alkyl-Superose HR 5/5 hydrophobic interaction and Bio-Sil TSK-250 gel permeation column chromatography. Sodium dodecyl sulfate – polyacrylamide gel electrophoresis and protein staining of the catalytically active and concentrated enzyme fractions from the gel permeation columns revealed the presence of one band of Mr 64 000. The glucocerebrosidase preparation purified to homogeneity was digested with peptide N-glycosidase F that cleaves N-linked oligosacchar

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6

Yang, Yi, Xianfu Luo, Fuhua Yan, et al. "Effect of zoledronic acid on vertebral marrow adiposity in postmenopausal osteoporosis assessed by MR spectroscopy." Skeletal Radiology 44, no. 10 (2015): 1499–505. http://dx.doi.org/10.1007/s00256-015-2200-y.

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7

Nemcsik-Bencze, Zsófia, Szabolcs Várbíró, Gábor Rudas, and János Nemcsik. "Az izolált septum pellucidum hiány praenatalis diagnosztikája ultrahang- és mágneses rezonancia képalkotó vizsgálattal." Orvosi Hetilap 161, no. 52 (2020): 2195–200. http://dx.doi.org/10.1556/650.2020.31912.

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Összefoglaló. A septoopticus dysplasia, vagy más néven De Morsier-szindróma egy ritka, az agy középvonali képleteit érintő rendellenesség, mely a septum pellucidum hiányával, hypophysis-diszfunkcióval, látóideg-hypoplasiával és mentális visszamaradottsággal jár együtt. A septum pellucidum hiánya önmagában is előfordulhat izolált formában, de ennek septoopticus dysplasiától való praenatalis elkülönítése jelentős diagnosztikai kihívást jelent. Az izolált septum pellucidum hiány a kevés, rendelkezésünkre álló irodalmi adat alapján ártalmatlan anatómiai variáció. Esetbemutatásunkban a magas mágnes

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8

Smal, J., J. Closset, G. Hennen, and P. de Meyts. "Receptor-binding and down-regulatory properties of 22000-Mr human growth hormone and its natural 20000-Mr variant on IM-9 human lymphocytes." Biochemical Journal 225, no. 2 (1985): 283–89. http://dx.doi.org/10.1042/bj2250283.

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Our earlier binding studies of the 22000- and 20000-Mr variants of human growth hormone (somatotropin) to pregnant-rabbit liver and mammary receptors [Closset, Smal, Gomez & Hennen (1983) Biochem. J. 214, 885-892] suggested that the 20000-Mr variant was a lower-affinity analogue of the 22000-Mr molecule. Since the receptor population in these tissues is not fully characterized, we have now investigated the binding of both variants to the well-characterized and highly specific human-growth-hormone receptor of the human lymphocyte IM-9 cell line. The maximum bindability of radioiodinated 220

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9

Manjón, José V., Pierrick Coupé, Luis Martí-Bonmatí, D. Louis Collins, and Montserrat Robles. "Adaptive non-local means denoising of MR images with spatially varying noise levels." Journal of Magnetic Resonance Imaging 31, no. 1 (2009): 192–203. http://dx.doi.org/10.1002/jmri.22003.

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10

Lessa, Cleber Rodrigo de Lima, Douglas Martinazzi, Arlan Pacheco Figueiredo, Rodrigo Batista Machado, Claudia Fanezi, and Telmo Strohaecker. "Microstructural behavior of SAF 2205 Duplex Stainless Steel Welded by Friction Hydro Pillar Processing." Materials Research 19, no. 4 (2016): 928–36. http://dx.doi.org/10.1590/1980-5373-mr-2016-0023.

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11

Gerçek, Muhammed, Anca A. Irimie, Mustafa Gerçek, et al. "Dynamics of Cognitive Function in Patients with Heart Failure Following Transcatheter Mitral Valve Repair." Journal of Clinical Medicine 11, no. 14 (2022): 3990. http://dx.doi.org/10.3390/jcm11143990.

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Aims: Interventional transcatheter edge-to-edge mitral valve repair (TMVR) is an established treatment option for patients with severe mitral regurgitation (MR) and high operative risk. Cognitive impairment is one of the most common conditions among often extensive comorbidities in these patients. The specific patterns of cognitive decline and particularly the effect of TMVR are not well described. Thus, this study aimed to investigate into the impact of TMVR on cognitive impairment, exercise capacity, and quality of life. Methods: Cognitive function (executive, naming, memory, attention, lang

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12

Biko, David M., Richard Davidson, Andres Pena, and Diego Jaramillo. "Proximal focal femoral deficiency: evaluation by MR imaging." Pediatric Radiology 42, no. 1 (2011): 50–56. http://dx.doi.org/10.1007/s00247-011-2203-3.

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13

Rigo, Michele, Niccolò Giaj-Levra, Rosario Mazzola, et al. "2206: First pilot worldwide adaptive treatment with Comprehensive Motion Management with 1.5T MR-Linac." Radiotherapy and Oncology 194 (May 2024): S2238—S2239. http://dx.doi.org/10.1016/s0167-8140(24)02453-8.

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14

Cho, Zang-Hee, Chang-Ki Kang, Chan-A. Park, et al. "Microvascular functional MR angiography with ultra-high-field 7 t MRI: Comparison with BOLD fMRI." International Journal of Imaging Systems and Technology 22, no. 1 (2012): 18–22. http://dx.doi.org/10.1002/ima.22008.

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15

Ley, Sebastian, Karl-Friedrich Kreitner, Christian Fink, Claus P. Heussel, Mathias M. Borst, and Hans-Ulrich Kauczor. "Assessment of pulmonary hypertension by CT and MR imaging." European Radiology 14, no. 3 (2004): 359–68. http://dx.doi.org/10.1007/s00330-003-2208-x.

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16

Koenig, James Karl, Maya E. Pring, and Jerry R. Dwek. "MR evaluation of femoral neck version and tibial torsion." Pediatric Radiology 42, no. 1 (2011): 113–15. http://dx.doi.org/10.1007/s00247-011-2206-0.

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17

Whelihan, Matthew F., and Kenneth G. Mann. "Plasma Procofactor Activation by Factor Xla." Blood 112, no. 11 (2008): 1024. http://dx.doi.org/10.1182/blood.v112.11.1024.1024.

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Abstract The procofactors FV and FVIII are activated by thrombin, FXa and plasmin. During contact pathway-initiated thrombin generation, FXIa activates FIX thus feeding into the coagulation cascade; however, the procofactors FVIII and FV must be activated to achieve a robust level of thrombin generation. We tested the hypothesis that FXIa can activate FV and FVIII. FV (1uM) was subjected to FXIa (100nM) proteolysis. During the reaction the relative activity and integrity were measured at selected time points using a one stage PT clotting assay and SDS-PAGE. Over the 60 minute time course, FV s

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18

Lee, Chan Woo, In-Ho Kim, and Hyung-Jo Jung. "Fabrication and Characterization of Natural Rubber-Based Magnetorheological Elastomers at Large Strain for Base Isolators." Shock and Vibration 2018 (June 4, 2018): 1–12. http://dx.doi.org/10.1155/2018/7434536.

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Анотація:

To withstand harsh conditions and have a moderate strength, it is desirable to use natural rubber for base isolators. In addition, previous studies have measured the magnetorheological (MR) effect under low-strain range, mostly within 10%. In the reality, it is necessary to evaluate the performance under large-strain range for base isolators. In this study, material properties of natural rubber-based MREs with various mixing ratios were evaluated under large-strain range (~100%). In the first step, MREs with various iron ratios were fabricated and evaluated to observe the MR effect according t

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19

Boldt, Julian, Kurt Rottner, Marc Schmitter, et al. "High-resolution MR imaging for dental impressions: a feasibility study." Clinical Oral Investigations 22, no. 3 (2017): 1209–13. http://dx.doi.org/10.1007/s00784-017-2204-1.

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20

Kulik, D. K., and A. T. Varakin. "Selenium-containing drug together with the feed additive Benut in the rations of steers." Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), no. 5 (April 28, 2022): 13–20. http://dx.doi.org/10.33920/sel-05-2205-02.

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Currently, there is great interest in the use of selenium drugs in animal husbandry. Chickpea is high-containing in selenium and protein. The feed additive Benut, made on the basis of chickpea, has a high content of selenium. At the same time, its active interaction with proteins was revealed. The purpose of the work was to increase the meat productivity and quality of beef of steers when using the selenium-containing drug DAFS-25 in rations together with the feed additive Benut. In order to conduct the experiment, according to the principle of analogues 3 groups of Aberdeen-Angus steers were

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21

NAKASO, Ryodai, Kazuo KASHIYAMA, Kodai OHARA, and Tsuyoshi KOTOURA. "DEVELOPMENT OF A HYBRID MR VISUALIZATION SYSTEM USING LOCATION-BASED AND MARKER-BASED METHODS." Japanese Journal of JSCE 81, no. 22 (2025): n/a. https://doi.org/10.2208/jscejj.24-22008.

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22

Lee, Seyoung, Taegyu Um, Jeeyeon Lee, et al. "Abstract 3844: Clinical implications of mixed response on prognosis of non-small cell lung cancer (NSCLC) patients treated with Immunotherapy." Cancer Research 84, no. 6_Supplement (2024): 3844. http://dx.doi.org/10.1158/1538-7445.am2024-3844.

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Abstract Background: Current methods for assessing the response of lung cancer patients to therapy (e.g. RECIST criteria) lack consideration for mixed response (MR) where some lesions increase while others decrease simultaneously. MR poses a challenge in deciding the continuation of therapy. Understanding the clinical implications of MR on patient prognosis within radiographic response categories is crucial for establishing effective treatment strategies for NSCLC. Methods: This study analyzed 177 NSCLC patients with ≥2 lesions receiving first-line systemic treatment with immunotherapy. Clinic

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23

Choi, Seung Hong, Keon Ha Kim, Woo Kyung Moon, et al. "Comparison of lymph node metastases assessment With the use of USPIO-enhanced MR imaging at 1.5 T versus 3.0 T in a rabbit model." Journal of Magnetic Resonance Imaging 31, no. 1 (2009): 134–41. http://dx.doi.org/10.1002/jmri.22020.

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24

Barnard, Trish. "Indigenised Souvenirs and Homewares in the Glenn Cooke Collection." Memoirs of the Queensland Museum - Culture 10 (December 2016): 107–15. http://dx.doi.org/10.17082/j.2205-3239.10.2016-08.

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This paper offers an interpretive evaluation of a collection that was donated to the Queensland Museum by Mr Glenn R. Cooke. The collection consists of 1,395 souvenir tourist objects and items of domestic homeware decorated with indigenised motifs that were manufactured for the Australian market between the 1930s and the 1980s. The motifs on many of the objects are based on traditional designs of rainforest Aboriginal groups from the Wet Tropics of North Queensland, misappropriated by non-Indigenous artists and craft-workers. Research into the sources of the motifs traces the transformation of

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25

Komachali, Sajad Rafiee, Zakieh Siahpoosh, and Mansoor Salehi. "Two novel mutations in ALDH18A1 and SPG11 gene found by whole-exome sequencing in spastic paraplegia disease patients in Iran." Genomics & Informatics 20, no. 3 (2022): e30. http://dx.doi.org/10.5808/gi.22030.

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Hereditary spastic paraplegia is a not common inherited neurological disorder with heterogeneous clinical expressions. ALDH18A1 (located on 10q24.1) gene-related spastic paraplegias (SPG9A and SPG9B) are rare metabolic disorders caused by dominant and recessive mutations that have been found recently. Autosomal recessive hereditary spastic paraplegia is a common and clinical type of familial spastic paraplegia linked to the SPG11 locus (locates on 15q21.1). There are different symptoms of spastic paraplegia, such as muscle atrophy, moderate MR, short stature, balance problem, and lower limb we

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26

Molnarova, Zuzana, Marie Machatkova, Ladislav Machal, Jindra Horakova, and Katerina Hanzalova. "A potential relationship between the acrosome response characteristics of bovine spermatozoa and their in vitro fertilizing ability." Zygote 14, no. 1 (2006): 63–69. http://dx.doi.org/10.1017/s096719940600356x.

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The aim of the work was to study a potential relationship between acrosome response characteristics of bovine spermatozoa and their ability to fertilize oocytes and produce in vitro embryos. Sperm of artificial insemination bulls with a high rate (22.0 ± 4.1%, group A, n = 7) or a low rate (10.3 ± 4.1%, group B, n = 8) of embryos were used. For acrosome assessment, motile spermatozoa from a Percoll gradient were incubated with or without heparin and examined by the fix-vital sperm assay (FVSA). The differences between the heparin-treated (H+) and the non-treated (H−) spermatozoa were significa

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27

Liu, Xing-Hai, Jian-Quan Weng, and Cheng-Xia Tan. "Synthesis, Crystal Structure, and Fungicidal Activity of 5-(4-cyclopropyl-5-((3-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole." Journal of Chemistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/306361.

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A new 1,2,3-thiadiazole compound was synthesized and characterized. The crystal structure of the title compound (C15H14FN5S2, Mr = 347.43) has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group P-1 witha=7.0490(14),b=9.0212(18),c=12.799(3) Å,α= 89.97(3)°,β= 82.27(3)°,γ= 73.17(3)°,V= 771.3(3) Å3, Z = 2, F(000) = 360, Dc = 1.496 g/cm3,μ= 0.036 mm−1, the finalR1= 0.0358, andwR2= 0.0986 for 2204 observed reflections withI>2σ(I). A total of 5697 reflections were collected, of which 2719 were independent (Rint=0.0028). The herbicidal activity of title co

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28

Gaudino, Chiara, Raluca Cosgarea, Sabine Heiland, et al. "MR-Imaging of teeth and periodontal apparatus: an experimental study comparing high-resolution MRI with MDCT and CBCT." European Radiology 21, no. 12 (2011): 2575–83. http://dx.doi.org/10.1007/s00330-011-2209-0.

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29

Yuan, Z. J., R. Zhao, J. Y. Li, et al. "AB0052 GENETIC EVIDENCE REVEALS CAUSAL LINK BETWEEN RHEUMATOID ARTHRITIS AND mTOR PROTEINS： A MENDELIAN RANDOMIZATION STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1205.1–1205. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3751.

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BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disease with hyperplasia of joint tissue and synovial inflammation1. And the mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase, which relates with cellular metabolism, promotes cell growth and inflammatory process2. Some studies show that some downstream proteins of mTOR are associated with RA, but having no directly genetic evidence.ObjectivesWe conducted Mendelian randomization (MR) study to discover the genetically and statistically casual association between mTOR and RA.MethodsA two-sample MR study was appl

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30

Arroussi, Mohammed, Jiajia Wu, Liyang Zhu, Peng Wang, Dun Zhang, and Wenkai Wang. "Effect of preferential growth of Shewanella oneidensis MR-1 on microbial corrosion of constituent phases of 2205 duplex stainless steel." Bioelectrochemistry 163 (June 2025): 108859. https://doi.org/10.1016/j.bioelechem.2024.108859.

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31

Vasquez, R. J., D. L. Gard, and L. Cassimeris. "XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover." Journal of Cell Biology 127, no. 4 (1994): 985–93. http://dx.doi.org/10.1083/jcb.127.4.985.

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We have used video-enhanced DIC microscopy to examine the effects of XMAP, a Mr 215,000 microtubule-associated protein from Xenopus eggs (Gard, D.L., and M. W. Kirschner. 1987. J. Cell Biol. 105:2203-2215), on the dynamic instability of microtubules nucleated from axoneme fragments in vitro. Our results indicate that XMAP substantially alters the parameters of microtubule assembly at plus ends. Specifically, addition of 0.2 microM XMAP resulted in (a) 7-10-fold increase in elongation velocity, (b) approximately threefold increase in shortening velocity, and (c) near elimination of rescue (the

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32

Kollmer, Jennifer, Markus Weiler, Jan Purrucker, et al. "MR neurography biomarkers to characterize peripheral neuropathy in AL amyloidosis." Neurology 91, no. 7 (2018): e625-e634. http://dx.doi.org/10.1212/wnl.0000000000006002.

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ObjectiveTo detect, localize, and quantify peripheral nerve lesions in amyloid light chain (AL) amyloidosis by magnetic resonance neurography (MRN) in correlation with clinical and electrophysiologic findings.MethodsWe prospectively examined 20 patients with AL-polyneuropathy (PNP) and 25 age- and sex-matched healthy volunteers. After detailed neurologic and electrophysiologic testing, the patient group was subdivided into mild and moderate PNP. MRN in a 3.0 tesla scanner with anatomical coverage from the lumbosacral plexus and proximal thigh down to the tibiotalar joint was performed by using

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33

deVries, A., W. Judmaier, J. Griebel, et al. "2206 Monitoring of tumor microcirculation during fractionated radiotherapy in patients with rectal carcinomas: A clinical study using contrast enhanced MR imaging." International Journal of Radiation Oncology*Biology*Physics 36, no. 1 (1996): 377. http://dx.doi.org/10.1016/s0360-3016(97)85777-x.

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34

Wawolangi, Natalia Enjellina, Grace Adonia Josephine Rumagit, and Charles Reijnaldo Ngangi. "Profil Usaha Mie Ba Garuda Asli Di Maumbi Kecamatan Kalawat Kabupaten Minahasa Utara." Journal of Agribusiness and Rural Development (Jurnal Agribisnis dan Pengembangan Pedesaan) 5, no. 4 (2024): 1–8. http://dx.doi.org/10.35791/agrirud.v5i4.56409.

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The purpose of this research is to describe the Business Profile of Mie Ba Garuda Original Maumbi, Kalawat District, North Minahasa Regency. Identify the history contained in the Mie Ba Garuda Asli restaurant. Identify what raw materials are used in the process of making Original Ba Garuda Noodles. Analyzing the profit of selling the number of ba meat noodle products produced by Mie Ba Garuda Asli. The results showed that the original ba garuda noodle business was opened in 1965 by Mr. Endi Lucas and was located on Jalan Garuda. This Mie Ba Garuda Asli restaurant is open every Monday - Saturda

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QIN, Yong-Mei, Matti H. POUTANEN, Heli M. HELANDER та ін. "Peroxisomal multifunctional enzyme of β-oxidation metabolizing d-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization". Biochemical Journal 321, № 1 (1997): 21–28. http://dx.doi.org/10.1042/bj3210021.

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In the present study we have cloned and characterized a novel rat peroxisomal multifunctional enzyme (MFE) named perMFE-II. The purified 2-enoyl-CoA hydratase 2 with an Mr of 31500 from rat liver [Malila, Siivari, Mäkelä, Jalonen, Latipää, Kunau and Hiltunen (1993) J. Biol. Chem. 268, 21578–21585] was subjected to tryptic fragmentation and the resulting peptides were isolated and sequenced. Surprisingly, the full-length cDNA, amplified by PCR, had an open reading frame of 2205 bp encoding a polypeptide with a predicted Mr of 79331 and contained a potential peroxisomal targeting signal in the C

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Baricos, W. H., Y. Zhou, R. W. Mason, and A. J. Barrett. "Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane." Biochemical Journal 252, no. 1 (1988): 301–4. http://dx.doi.org/10.1042/bj2520301.

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Cathepsins B and L were purified from human kidney. SDS/polyacrylamide-gel electrophoresis demonstrated that cathepsins B and L, Mr 27000-30000, consist of disulphide-linked dimers, subunit Mr values 22000-25000 and 5000-7000. The pH optimum for the hydrolysis of methylcoumarylamide (-NHMec) substrates (see below) is approx. 6.0 for each enzyme. Km and kcat. are 252 microM and 364s-1 and 2.2 microM and 25.8 s-1 for the hydrolysis of Z-Phe-Arg-NHMec (where Z- represents benzyloxycarbonyl-) by cathepsins B and L respectively, and 184 microM and 158 s-1 for the hydrolysis of Z-Arg-Arg-NHMec by ca

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Ezziddin, Samer, Mared Attassi, Charlotte Jane Yong-Hing, et al. "Factors predicting outcome of G1/2 GEP NET after PRRT with Lu177-octreotate." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14565-e14565. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14565.

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e14565 Background: Outcome analyses of G1/2 NEN stage IV after peptide receptor radionuclide therapy (PRRT) are still limited, especially with regard to the impact of the Ki-67 index. This study aims to establish predictors of survival. Methods: Retrospective analysis of 74 consecutive GEP NET patients undergoing PRRT with 177Lu-octreotate. Patients had unresectable metastatic disease and a G1/2 grading (33 pancreatic, 41 non-pancreatic GEP- NET), documented morphologic or clinical progression within < 12 months and/or uncontrolled disease. Response (modified SWOG criteria) was correlated w

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Landheer, Karl, and Christoph Juchem. "Erratum to: Dephasing optimization through coherence order pathway selection (DOTCOPS) for improved crusher schemes in MR spectroscopy (Magn Reson Med. 2019;81:2209‐2222)." Magnetic Resonance in Medicine 82, no. 2 (2019): 854–55. http://dx.doi.org/10.1002/mrm.27776.

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Castillo, C. J., P. Colburn, and V. Buonassisi. "Characterization and N-terminal sequence of a heparan sulphate proteoglycan synthesized by endothelial cells in culture." Biochemical Journal 247, no. 3 (1987): 687–93. http://dx.doi.org/10.1042/bj2470687.

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We have isolated from the conditioned medium of an established endothelial cell line a heparan sulphate proteoglycan whose involvement in the inhibition of the extrinsic coagulation pathway was reported in previous studies [Colburn & Buonassisi (1982) Biochem. Biophys. Res. Commun. 104, 220-227]. The proteoglycan was purified by gel filtration and ion-exchange chromatography, and appears to be free of contaminating proteins as determined by polyacrylamide-gel electrophoresis of the radioiodinated protein core before and after removal of the glycosaminoglycan chains by treatment with hepari

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Ali, Aydın Urul, and Ayça Kaya Gamze. "Dâhilde İşleme Rejiminin Türkiye Ekonomisine Olan Etkileri ve Demir Çelik Sektörü Üzerine Bir Araştırma." SOCIAL SCIENCES STUDIES JOURNAL 10, no. 3 (2024): 369–83. https://doi.org/10.5281/zenodo.10903389.

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sektöründe ihracatın ve ürün çeşitliliğinin arttırılması, DİR kapsamında verilen teşviklerin amacına uygun kullanılıp kullanılmadığı, küresel pazarlarda Türk firmalarının rekabet edebilmesinde DİR’in daha etkili kullanılması için yapılması gerekenlerin ortaya çıkarılması amaçlanmıştır. Bu çalışma, DİR sistem ve uygulamalarının demir-çelik sektöründe faaliyet gösteren işletmelerle ilgili araştırma yapanlara ve Türk demir çelik sektöründe dış ticaretle uğraşan firmalara DİR kapsamın

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Autry, Adam, Brian Chung, Hsin-Yu Chen, et al. "CBMT-36. INITIAL EXPERIENCE WITH HYPERPOLARIZED [2-13C]PYRUVATE MR IMAGING IN PATIENTS WITH IDH-MUTANT GLIOMA." Neuro-Oncology 21, Supplement_6 (2019): vi41. http://dx.doi.org/10.1093/neuonc/noz175.158.

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Abstract INTRODUCTION Hyperpolarized (HP) carbon-13 MR imaging allows for real-time non-invasive measurement of metabolism. Using HP [2-13C]pyruvate as a molecular probe enables the measurement of both aerobic glycolysis ([2-13C]lactate) and oxidative metabolism (such as [5-13C]glutamate and [5-13C]glutamine). This study presents the initial patient experience of acquiring HP [2-13C]pyruvate MR spectroscopic data. METHODS Two patients who presented with IDH-mutant gliomas (43 year-old male, grade II astrocytoma, RT/TMZ; 33 year-old female, grade III oligodendroglioma, no RT/TMZ) considered rad

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Chiang, Anne C., Russell W. Madison, Yanmei Huang, et al. "Abstract 971: Validation of a tumor-naïve circulating tumor DNA (ctDNA) response monitoring panel in advanced non-small cell lung cancer (aNSCLC)." Cancer Research 84, no. 6_Supplement (2024): 971. http://dx.doi.org/10.1158/1538-7445.am2024-971.

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Abstract Introduction: Monitoring of ctDNA can be a minimally invasive complement to tumor imaging for assessing treatment effect. Technical limitations require methods to distinguish tumor signal from clonal hematopoiesis (CH), often including non-tumor sequencing. We developed a tumor-naïve panel (FoundationOne® Monitor) to quantify ctDNA tumor fraction (TF). TF analytical validation used peripheral blood mononuclear cell (PBMC) sequencing. We then leveraged plasma collected serially from patients with aNSCLC in the real-world (rw) Prospective Clinico-Genomic (PCG; NCT04180176) study to inve

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SUZUKI, Takashi, Masami NAKANO, and Yuichi HIKICHI. "220 Performance Evaluation of Transfemoral Prostheses Controlled by Optional Motions Using MR Fluid Brake Knee Joint." Proceedings of Conference of Tohoku Branch 2012.47 (2012): 246–47. http://dx.doi.org/10.1299/jsmeth.2012.47.246.

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Chen, Wenming, Peng Wei, Shifang Yang, et al. "Transiently Elevated AST/LDH Are Associated with Clinical Response to Recombinant Circularly Permuted TRAIL (CPT) Plus Thalidomide in Patients with Relapsed and/or Refractory Multiple Myeloma." Blood 124, no. 21 (2014): 3478. http://dx.doi.org/10.1182/blood.v124.21.3478.3478.

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Abstract Introduction: Circularly permuted TRAIL (CPT), a recombinant mutant of human Apo2L/TRAIL, is a promising anti-tumor candidate. In previous phase1/2 clinical trials of single-agent CPT in patients with relapsed and/or refractory multiple myeloma (RRMM), transient elevations of serum AST and LDH were observed early after CPT treatment in most response patients, but not in the non-respondent. Positive correlations were found between increased AST/LDH on day 2 or 3 (24 or 48 hours) after CPT initial dosing and the clinical responses to CPT. Objective: To determine whether transiently elev

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Okolie, Ugo Chuks, and Idongesit David Udom. "Determinants of Customer Patronage of Fast Food Outlets in Benin City." Journal of Economics and Management Research 10 (January 2022): 74–99. http://dx.doi.org/10.22364/jemr.10.05.

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This study critically examined the factors influencing customer patronage of fast food outlets in Benin City. Specifically, the independent variables examined include quality of service delivery, brand image and price and how they relate to customer patronage. The study adopted survey research design. The population includes all customers that patronise fast food outlets in Benin City, Edo State. Fifty (50) respondents each were chosen in four fast food outlets namely: Mr. Biggs, Mat Ice, Kada Food and Omega Food to have a sample size of two hundred (200) out of which 188 questionnaires were f

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Latagliata, Roberto, Imma Attolico, Malgorzata Monika Trawinska, et al. "Bosutinib in the Real-Life Treatment of Chronic Phase Chronic Myeloid Leukemia (CML) Patients Aged > 65 Years Resistant/Intolerant to Frontline Tyrosine-Kynase Inhibitors." Blood 134, Supplement_1 (2019): 1649. http://dx.doi.org/10.1182/blood-2019-127029.

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Background Bosutinib is a 2nd generation tyrosine-kinase inhibitor (TKI) active in Chronic Myeloid Leukemia (CML) patients resistant or intolerant to frontline imatinib, dasatinib or nilotinib; the favourable toxicity profile makes bosutinib potentially useful in elderly patients, but at present there are no data in unselected cohorts of these subjects. Aim To highlight this issue, a real-life cohort of 91 patients followed in 21 Italian Centers and treated with bosutinib when aged > 65 years was retrospectively evaluated. Patients The main clinical features of the whole cohort at diagnosis

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Rahman, MHD Pathur, and Fadly A. Kurniawan. "ANALISA KEKUATAN MATERIAL BAHAN CARBON STEEL AISI 1018 DAN BAJA TULANGAN POLOS SNI P40 SEBAGAI ANGKUR PADA TOWER DENGAN METODE UJI TARIK." Buletin Utama Teknik 17, no. 3 (2022): 291–301. http://dx.doi.org/10.30743/but.v17i3.5376.

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Perkembangan teknologi komunikasi di Indonesia terus mengalami perkembangan yang cukup pesat. Perkembangan ini memicu peningkatan pembangunan menara pemancar (tower) yang merupakan perangkat penting dalam teknologi komunikasi dan informasi. Sebagai konsekuensi dari perkembangan ini maka harus diiringi dengan bertambahnya jumlah kontruksi menara di daerah pemukiman dan perkotaan yang dapat berakibat buruk apabila kontruksi menara (tower) tidak memiliki sambungan yang baik antar tanah dan besi menara. Setiap pembangunan menara di perlukan sambungan (angkur) yang sangat kuat. Salah satu faktor ya

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Yamaoka, K., S. B. Cohen, N. Sugiyama, et al. "POS0650 PREDICTORS OF DURABLE CLINICAL RESPONSE TO TOFACITINIB 11 MG ONCE DAILY WITH OR WITHOUT METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS: POST HOC ANALYSIS OF DATA FROM A PHASE 3b/4 METHOTREXATE WITHDRAWAL STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 563.2–564. http://dx.doi.org/10.1136/annrheumdis-2021-eular.357.

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Background:ORAL Shift, a global Phase 3b/4 non-inferiority study, demonstrated sustained efficacy and safety of tofacitinib modified-release (MR) 11 mg once daily (QD) following methotrexate (MTX) withdrawal in patients with rheumatoid arthritis (RA) who achieved Clinical Disease Activity Index (CDAI) low disease activity (LDA) after treatment with tofacitinib + MTX.1Objectives:To assess predictors of durable clinical response in patients receiving tofacitinib MR 11 mg QD in ORAL Shift.Methods:ORAL Shift (NCT02831855) enrolled patients aged ≥18 years with moderate to severe RA and an inadequat

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Shakur, Sophia F., Ali Alaraj, Nasya Mendoza-Elias, Muhammad Osama, and Fady T. Charbel. "Hemodynamic characteristics associated with cerebral aneurysm formation in patients with carotid occlusion." Journal of Neurosurgery 130, no. 3 (2019): 917–22. http://dx.doi.org/10.3171/2017.11.jns171794.

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OBJECTIVEThe pathogenesis of cerebral aneurysms in patients with internal carotid artery (ICA) occlusion is hypothesized to be hemodynamic. For the first time, the authors quantify the hemodynamic characteristics associated with aneurysm formation in patients with ICA occlusion.METHODSRecords of patients with unilateral ICA stenosis or occlusion ≥ 90% who underwent hemodynamic assessment before treatment using quantitative MR angiography were retrospectively reviewed. The patients were classified into 2 groups based on the presence or absence of aneurysms. The hemodynamic parameters of flow vo

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Гурьянова, Маргарита Анатольевна, В. И. Казей, О. А. Шухов та ін. "Промежуточные результаты российского проспективного многоцентрового клинического исследования READIT-2020 (снижение дозы ингибиторов тирозинкиназ при ХМЛ, концентрация иматиниба/нилотиниба в плазме, сохранение молекулярного ответа, лекарственная токсичность)". Clinical Oncohematology 17, № 4 (2024): 347–59. https://doi.org/10.21320/2500-2139-2024-17-4-347-359.

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AIM. To measure the trough and maximum plasma concentrations of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) patients on standard and reduced doses of the drugs, to evaluate the impact of TKI plasma concentration on the loss of major/deep molecular response (MR) after dose reduction and the impact of TKI plasma concentration on drug toxicity changes. MATERIALS & METHODS. The trial enrolled 46 imatinib and 16 nilotinib recipients. The trough (Сtrough) and maximum (Cmax) TKI plasma concentrations were measured. On imatinib/nilotinib therapy, Ctrough was analyzed in 104

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