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Готові списки джерел за темами / Multi unit particulates (MUPS) / Статті в журналах

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Статті в журналах з теми "Multi unit particulates (MUPS)"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Dr, . M. Sunitha Reddy* Raju Eddagiri S. Muhammad Fazal Hl Haq Dr. V. Venkateswarlu. "DESIGN AND IN-VITRO CHARACTERIZATION OF DELAYED RELEASE MULTI UNIT PARTICULATES USING WURSTER TECHNOLOGY." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4315–24. https://doi.org/10.5281/zenodo.1098072.

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Анотація:

The aim of the present research was to design and characterize delayed release Multi Unit Particles (MUPS). These were produced primarily for the purpose of oral modified release dosage forms having gastro resistant and delayed-release properties. During the development of MUPS agglomeration, generations of fines and twins formation are identified as critical issues. The delayed release multiple units were prepared by layering drug suspension using Wurster technology. The prepared multi unit particulates consist of successive layers of drug layer (Esomeprazole), barrier coat and enteric coat (

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2

Parihar, Akshay, Bhupendra Gopalbhai Prajapati, Kiran Patel, and Himanshu Paliwal. "Formulation, evaluation, and optimization of the omeprazole magnesium multi-unit particulate controlled release tablets using different concentrations of polymers." IP International Journal of Comprehensive and Advanced Pharmacology 7, no. 4 (2023): 211–17. http://dx.doi.org/10.18231/j.ijcaap.2022.040.

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Multi-Unit Particulates (MUPs) with matrix pellets are used to develop controlled release products of various active pharmaceutical ingredients. They may allow improvement in solubility and thereby bioavailability of poorly soluble drugs. Omeprazole magnesium is a derivative of benzimidazole which belongs to the group of proton pump inhibitors that exhibits degradation in gastric acid with short biological life and variability in bioavailability. The drug degradation problem was overcome by the coating of pellets with enteric coating agents which disperse in the gastrointestinal tract more hom

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3

Agrawal, Surendra, Ketaki Joshi, and Ram Gaud. "Formulation development of multi unit particulate system (MUPS) for anti-diabetic drugs." Asian Journal of Pharmaceutical Sciences 11, no. 1 (2016): 77–78. http://dx.doi.org/10.1016/j.ajps.2015.10.060.

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4

Čierna, Martina, Pavel Mučaji, Miroslava Špaglová, Mária Čuchorová, and Oliver Macho. "Chitosan and Sodium Alginate Implementation as Pharmaceutical Excipients in Multiple-Unit Particulate Systems." Polymers 14, no. 14 (2022): 2822. http://dx.doi.org/10.3390/polym14142822.

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This study aimed to prepare and evaluate pellets containing acyclovir as a model drug. Pellets were prepared by the extrusion–spheronization process. Aqueous solutions of natural marine polymers (sodium alginate, chitosan) were compared to semi-synthetic hydroxypropyl methylcellulose (HPMC) in the role of binders. The study focused on the characterization of the pellet properties that are crucial for the formulation of the final dosage form, such as in multi-unit pellet system (MUPS) tablets or hard gelatin capsules filled with the pellets. Finally, the mentioned dosage forms were tested for d

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5

Khobragade, Deepak S., K. Vighneshwar, and Mrunali S. Potbhare. "Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for Extended Release." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1219–27. http://dx.doi.org/10.25258/ijddt.12.3.49.

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Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available but have their own disadvantages. The study was to designed formulate and evaluate the prolonged-release compressed multiple-unit pellet system of Metoprolol succinate. MUPS are novel formulations with benefits of both single and multi unit dosage forms and can provide extended drug delivery release profile and increase the efficiency profile of the drug. Metaprolol su

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6

Tushar, Tonge* Shilpa Borkar Jagdish Baheti. "A Review on Multiple Unit Pellet System (MUPS) Delivery Systems." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4474–90. https://doi.org/10.5281/zenodo.15533086.

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The pharmaceutical industry is currently concentrating on creating novel drug delivery systems that improve therapeutic efficacy and lessen adverse effects. When a medication product needs to be administered in a modified release pattern to senior patients, the oral drug delivery system becomes problematic, particularly because they have trouble swallowing. The design of solid dosage forms has made extensive use of Multiple Unit Pellet Systems (MUPS) tablets in recent years. One of the more recent and difficult technologies that combines the benefits of tablets with pellet-filled capsules in a

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7

Wanda B. Putri, Friesca S. Nurhaidah, Helmy Yusuf, and Maria L.A.D. Lestari. "Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl." MEDICINUS 36, no. 3 (2023): 36–47. http://dx.doi.org/10.56951/af7svb90.

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The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin

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8

Drechsler, Salome, Peter S. H. Leeflang, Tammo H. A. Bijmolt, and Martin Natter. "Multi-unit price promotions and their impact on purchase decisions and sales." European Journal of Marketing 51, no. 5/6 (2017): 1049–74. http://dx.doi.org/10.1108/ejm-12-2013-0729.

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Purpose The purpose of this paper is to compare the impact of different multi-unit promotions (MUPs) and a single-unit promotion (SUP) on store-level sales and consumer-level purchase probability and quantity decision. Design/methodology/approach The paper combines two empirical studies. Study 1 applies a hierarchical multiplicative model to store-level sales data for four product categories provided by a large Dutch retail chain. Study 2 presents a laboratory experiment in which the quantity requirements of the two focal MUP frames are manipulated to assess their impact on consumer purchase d

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9

Guo, Su Juan, Guo Zheng Kang, and Cheng Dong. "Numerical Simulations for Uniaxial Ratcheting of SiC_P/6061Al Composites Concerning Particulate Arrangement." Advanced Materials Research 26-28 (October 2007): 317–20. http://dx.doi.org/10.4028/www.scientific.net/amr.26-28.317.

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Based on three dimensional cubic unit cell models containing several particulates with certain particulate arrangements, the monotonic tensile and uniaxial ratcheting behaviors of particulate reinforced metal matrix composites (i.e., T6-treated SiCP/6061Al composites) were numerically simulated by using elastic-plastic finite element code ABAQUS with help of newly developed user material subroutine (UMAT). In the simulations, the effects of different particulate arrangements inside the unit cell models on the monotonic tensile and ratcheting behaviors of the composites were discussed. It is sh

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10

Thio, Daniel Robin, Paul Wan Sia Heng, and Lai Wah Chan. "MUPS Tableting—Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets." Pharmaceutics 14, no. 12 (2022): 2812. http://dx.doi.org/10.3390/pharmaceutics14122812.

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Multi-unit pellet system (MUPS) tablets were fabricated by compacting drug-loaded pellets of either crospovidone or microcrystalline cellulose core. These pellets were produced by extrusion-spheronization and coated with ethylcellulose (EC) for a sustained drug release function. Coat damage due to the MUPS tableting process could undermine the sustained release function of the EC-coated pellets. Deformability of the pellet core is a factor that can impact the extent of pellet coat damage. Thus, this study was designed to evaluate the relative performance of drug-loaded pellets prepared with ei

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11

Sangwai, Mayur, Surendra Sardar, and Pradeep Vavia. "Nanoemulsified orlistat-embedded multi-unit pellet system (MUPS) with improved dissolution and pancreatic lipase inhibition." Pharmaceutical Development and Technology 19, no. 1 (2012): 31–41. http://dx.doi.org/10.3109/10837450.2012.751404.

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12

Anisha, Gulhane Dr. Bhushan Bhoyar*. "A Review on Multi-Unit Particulate System: Advanced Technology for Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 780–89. https://doi.org/10.5281/zenodo.15597547.

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Анотація:

Pellets are agglomerates of fine powders or granules of bulk drugs and excipients typically ranging from about 0.5 to 1.5 mm. Multi-unit Particulates System technology refers to a pharmaceutical formulation approach in which a single dosage form, such as a tablet or capsule, contains multiple small, discrete pellets or granules. Each pellet acts as an individual drug delivery unit, often coated with one or more layers that control the release rate of the active pharmaceutical ingredient. Multi-Unit Particulate System consists of embedding many small pellet within one formulation. Types of Mult

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13

Kállai-Szabó, Nikolett, Miléna Lengyel, Dóra Farkas, et al. "Review on Starter Pellets: Inert and Functional Cores." Pharmaceutics 14, no. 6 (2022): 1299. http://dx.doi.org/10.3390/pharmaceutics14061299.

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Анотація:

A significant proportion of pharmaceuticals are now considered multiparticulate systems. Modified-release drug delivery formulations can be designed with engineering precision, and patient-centric dosing can be accomplished relatively easily using multi-unit systems. In many cases, Multiple-Unit Pellet Systems (MUPS) are formulated on the basis of a neutral excipient core which may carry the layered drug surrounded also by functional coating. In the present summary, commonly used starter pellets are presented. The manuscript describes the main properties of the various nuclei related to their

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14

Ivic, Branka, Svetlana Ibric, Gabriele Betz, and Djuric Zorica. "Optimization of drug release from compressed multi unit particle system (MUPS) using generalized regression neural network (GRNN)." Archives of Pharmacal Research 33, no. 1 (2010): 103–13. http://dx.doi.org/10.1007/s12272-010-2232-8.

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15

Tyagi, Puneet, Ruchit Trivedi, Sergei Pechenov, et al. "Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach." Journal of Controlled Release 338 (October 2021): 784–91. http://dx.doi.org/10.1016/j.jconrel.2021.09.002.

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16

Lara Garcia, Raymar Andreina, Jesús Alberto Afonso Urich, Andreina Isabel Afonso Urich, Dalibor Jeremic, and Johannes Khinast. "Application of Lactose Co-Processed Excipients as an Alternative for Bridging Pharmaceutical Unit Operations: Manufacturing an Omeprazole Tablet Prototype via Direct Compression." Scientia Pharmaceutica 93, no. 2 (2025): 24. https://doi.org/10.3390/scipharm93020024.

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Анотація:

Improving the manufacturability of drug formulations via direct compression has been of great interest for the pharmaceutical industry. Selecting excipients plays a vital role in obtaining a high-quality product without the wet granulation processing step. In particular, for diluents which are usually present in a larger amount in a formulation, choosing the correct one is of utmost importance in the production of tablets via any method. In this work, we assessed the possibility of manufacturing a small-molecule drug product, omeprazole, which has been historically manufactured via a multi-ste

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17

Pfeiffer, G., and K. Kunze. "Discriminant classification of motor unit potentials (MUPs) successfully separates neurogenic and myopathic conditions. A comparion of multi- and univariate diagnostical algorithms for MUP analysis." Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control 97, no. 5 (1995): 191–207. http://dx.doi.org/10.1016/0924-980x(95)00072-0.

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18

Pfeiffer, G. "Discriminant classification of motor unit potentials (MUPs) successfully separates neurogenic and myopathic conditions. A comparison of multi- and univariate diagnostical algorithms for MUP analysis." Electroencephalography and Clinical Neurophysiology 97, no. 5 (1995): 191–207. http://dx.doi.org/10.1016/0013-4694(95)00072-7.

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19

Pochwała, Sławomir, Arkadiusz Gardecki, Piotr Lewandowski, Viola Somogyi, and Stanisław Anweiler. "Developing of Low-Cost Air Pollution Sensor—Measurements with the Unmanned Aerial Vehicles in Poland." Sensors 20, no. 12 (2020): 3582. http://dx.doi.org/10.3390/s20123582.

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This article presents the capabilities and selected measurement results from the newly developed low-cost air pollution measurement system mounted on an unmanned aerial vehicle (UAV). The system is designed and manufactured by the authors and is intended to facilitate, accelerate, and ensure the safety of operators when measuring air pollutants. It allows the creation of three-dimensional models and measurement visualizations, thanks to which it is possible to observe the location of leakage of substances and the direction of air pollution spread by various types of substances. Based on these

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20

Tomiyoshi, Katsumi, Yuta Namiki, David J. Yang, and Tomio Inoue. "Production, Validation, and Exposure Dose Measurement of [13N]Ammonia Under Academic Good Manufacturing Practice Environments." Pharmaceutics 17, no. 5 (2025): 667. https://doi.org/10.3390/pharmaceutics17050667.

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Objective: Current good manufacturing practice (cGMP) guidance for positron emission tomography (PET) drugs has been established in Europe and the United States. In Japan, the Pharmaceuticals and Medical Devices Agency (PMDA) approved the use of radiosynthesizers as medical devices for the in-house manufacturing of PET drugs in hospitals and clinics, regardless of the cGMP environment. Without adequate facilities, equipment, and personnel required by cGMP regulations, the quality assurance (QA) and clinical effectiveness of PET drugs largely depend on the radiosynthesizers themselves. To bridg

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21

PRIYANKA, BOTE, Gaware Vinayak, and Kumar Panda Sanjay. "Multiple-Unit Pellet System (MUPS): A Review." October 3, 2023. https://doi.org/10.5281/zenodo.8402055.

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Pelletization is a technique to convert drugs or excipients to small free flowing, spherical or semi spherical units, which are produced by agglomerating fine powdered drug/excipients with a binder solution. Pellets range in size, typically, between 0.5 – 2.0 mm. MUPS (Multiple Unit Pellet Systems) are multi- particulate in nature and are administered as tablets. These tablets disperse in stomach and intestine allowing constant drug release in systemic circulation. This article reviews the advantages, disadvantages, common industrial technique for preparation of pellets and challenges in

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22

RAMANI, KETAN B., and Vipul Patel. "Development of Mebeverine HCl Prolonged release Mini-tablets by thermoplastic granulation technique." International Journal of Pharmaceutical Sciences and Drug Research, May 30, 2020, 260–66. http://dx.doi.org/10.25004/ijpsdr.2020.120308.

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Mebeverine HCl is a BCS class-I drug and thus it possesses high solubility in aqueous media across the biological pH range. The marketed reference product is a multi-unit particulate system (MUPS) containing prolonged release pellets filled in hard gelatin capsule. In conventional manufacturing process, a huge quantity of solvents (aqueous and/or organic) is used to manufacture such dosage form. Additionally, it demands more processing time and efforts. Therefore, a prolonged release capsules dosage form of Mebeverine HCl was formulated using thermoplastic (melt) granulation technique without

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23

Steinert, R. E., W. Sybesma, R. Duss, et al. "In vitro validation of colon delivery of vitamin B2 through a food grade multi-unit particle system." Beneficial Microbes, October 29, 2024, 1–17. http://dx.doi.org/10.1163/18762891-bja00045.

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Abstract Colon target delivery of active ingredients is frequently applied in pharmaceutical products. However, in functional food and beverage applications, dietary supplements, and medical nutrition, formats targeting colonic delivery to improve human health are rare. Nevertheless, there is emerging evidence for beneficial effects of colonic delivered nutrients on gut microbiota and host health which increases the demand for sustainable food grade materials that are regulatory approved for application. In this paper, we describe a double layer coated multi-unit particle system (MUPS) with a

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24

Borra, Syam Prasad, M. Chenna Eswaraiah, and G. Kamalakar Reddy. "EVALUATION OF DIFFERENT SYNTHETIC AND NATURAL POLYMERS AS PROTECTIVE LAYER ON HIGHLY SOLUBLE AND HIGH DOSE DRUG METOPROLOL SUCCINATEFOR MANUFACTURING OF CONTROL RELEASE MULTI UNIT PELLETS TABLETS." International Journal of Applied Pharmaceutics, May 7, 2018, 69–76. http://dx.doi.org/10.22159/ijap.2018v10i3.25085.

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Objective: Evaluation of different natural and synthetic polymers as protective layer (PL) in the manufacturing of control release (CR) multi-unit pellets (MUPS) tablets, highly soluble and high dose drug metoprolol succinate (MS) was selected as model drug. The function of PL is to protect CR functional coating layer of pellets from damage during compression of MUPS tablets.Â Methods: MS is highly soluble biopharmaceutics classification system(BCS) Classâ€“I molecule, hence selected aqueous solution layering method for drug loading in fluid bed processor (FBP), optimized formulation was manuf

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25

Reddy, Dr M. Sunitha. "FORMULATION AND IN-VITRO CHARACTERIZATION OF MULTI UNIT PARTICULATES AS RESERVOIR SYSTEMS USING HYDROPHOBIC POLYMERS." World Journal of Pharmaceutical Research, April 1, 2017, 965–85. http://dx.doi.org/10.20959/wjpr20174-8104.

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26

Christian, W. Jay, John Flunker, Beverly May, et al. "Adult asthma associated with roadway density and housing in rural Appalachia: the Mountain Air Project (MAP)." Environmental Health 22, no. 1 (2023). http://dx.doi.org/10.1186/s12940-023-00984-x.

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Abstract Background Appalachian Kentucky is a rural area with a high prevalence of asthma among adults. The relative contribution of environmental exposures in the etiology of adult asthma in these populations has been understudied. Objective This manuscript describes the aims, study design, methods, and characteristics of participants for the Mountain Air Project (MAP), and focuses on associations between small area environmental exposures, including roadways and mining operations, and lifetime and current asthma in adults. Methods A cohort of residents, aged 21 and older, in two Kentucky cou

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27

Broznitsky, Natasha, Mona Shum, David Kinniburgh, et al. "A field investigation of 3 masks proposed as respiratory protection for wildland firefighters: a randomized controlled trial in British Columbia, Canada." Annals of Work Exposures and Health, September 23, 2024. http://dx.doi.org/10.1093/annweh/wxae073.

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Abstract Introduction Wildland firefighters are exposed through the lungs and skin to particulate matter, fumes, and vapors containing polycyclic aromatic hydrocarbons (PAH). Wearing respiratory protection should reduce pulmonary exposure, but there is uncertainty about the most effective and acceptable type of mask. Methods Firefighters from 6 unit crews working with the British Columbia Wildfire Service were approached and those consenting were randomly allocated within each crew to a “no mask” control group or to use 1 of 3 types of masks: X, half-face respirator with P100/multi gas cartrid

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