Статті в журналах: "Multicompartmental nanoparticles"

1

Rahmani, Sahar, and Joerg Lahann. "Recent progress with multicompartmental nanoparticles." MRS Bulletin 39, no. 3 (2014): 251–57. http://dx.doi.org/10.1557/mrs.2014.10.

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2

He, Xin, Yaqing Qu, Chengqiang Gao, and Wangqing Zhang. "Synthesis of multicompartment nanoparticles of a triblock terpolymer by seeded RAFT polymerization." Polymer Chemistry 6, no. 35 (2015): 6386–93. http://dx.doi.org/10.1039/c5py01041a.

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3

Liu, Jian, Tingting Liu, Jian Pan, Shaomin Liu, and G. Q. (Max) Lu. "Advances in Multicompartment Mesoporous Silica Micro/Nanoparticles for Theranostic Applications." Annual Review of Chemical and Biomolecular Engineering 9, no. 1 (2018): 389–411. http://dx.doi.org/10.1146/annurev-chembioeng-060817-084225.

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Mesoporous silica nanoparticles (MSNs) are promising functional nanomaterials for a variety of biomedical applications, such as bioimaging, drug/gene delivery, and cancer therapy. This is due to their low density, low toxicity, high biocompatibility, large specific surface areas, and excellent thermal and mechanical stability. The past decade has seen rapid advances in the development of MSNs with multiple compartments. These include hierarchical porous structures and core-shell, yolk-shell, and Janus structured particles for efficient diagnosis and therapeutic applications. We review advances in this area, covering the categories of multicompartment MSNs and their synthesis methods, with an emphasis on hierarchical structures and the incorporation of multiple functions. We classify multicompartment mesoporous silica micro/nanostructures, ranging from core-shell and yolk-shell structures to Janus and raspberry-like nanoparticles, and discuss their synthesis methods. We review applications of these multicompartment MSNs, including bioimaging, targeted drug/gene delivery, chemotherapy, phototherapy, and in vitro diagnostics. We also highlight the latest trends and new opportunities.

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4

Chen, Shengli, Xueying Chang, Pingchuan Sun, and Wangqing Zhang. "Versatile multicompartment nanoparticles constructed with two thermo-responsive, pH-responsive and hydrolytic diblock copolymers." Polymer Chemistry 8, no. 36 (2017): 5593–602. http://dx.doi.org/10.1039/c7py01182b.

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5

He, Xin, Quanlong Li, Pengfei Shi, Yongliang Cui, Shentong Li, and Wangqing Zhang. "A new strategy to prepare thermo-responsive multicompartment nanoparticles constructed with two diblock copolymers." Polym. Chem. 5, no. 24 (2014): 7090–99. http://dx.doi.org/10.1039/c4py01077a.

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6

Huang, Jing, Yakun Guo, Song Gu, et al. "Multicompartment block copolymer nanoparticles: recent advances and future perspectives." Polymer Chemistry 10, no. 25 (2019): 3426–35. http://dx.doi.org/10.1039/c9py00452a.

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7

Pochan, Darrin J., Jiahua Zhu, Ke Zhang, Karen L. Wooley, Caroline Miesch, and Todd Emrick. "Multicompartment and multigeometry nanoparticle assembly." Soft Matter 7, no. 6 (2011): 2500. http://dx.doi.org/10.1039/c0sm00960a.

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8

Qu, Yaqing, Fei Huo, Quanlong Li, Xin He, Shentong Li, and Wangqing Zhang. "In situ synthesis of thermo-responsive ABC triblock terpolymer nano-objects by seeded RAFT polymerization." Polym. Chem. 5, no. 19 (2014): 5569–77. http://dx.doi.org/10.1039/c4py00510d.

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Анотація:

Synthesis of thermo-responsive ABC triblock terpolymer nano-objects by seeded RAFT polymerization is achieved. At temperature above LCST, the triblock terpolymer nano-objects convert into multicompartment nanoparticles.

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9

Liu, Tingting, Wei Tian, Yunqing Zhu, Yang Bai, Hongxia Yan, and Jianzhong Du. "How does a tiny terminal alkynyl end group drive fully hydrophilic homopolymers to self-assemble into multicompartment vesicles and flower-like complex particles?" Polym. Chem. 5, no. 17 (2014): 5077–88. http://dx.doi.org/10.1039/c4py00501e.

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We report an unusual self-assembly behavior driven by a tiny terminal alkynyl end group in fully hydrophilic homopolymers which form multicompartment vesicles and flower-like nanoparticles in aqueous solution.

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10

Lunn, David J., John R. Finnegan, and Ian Manners. "Self-assembly of “patchy” nanoparticles: a versatile approach to functional hierarchical materials." Chemical Science 6, no. 7 (2015): 3663–73. http://dx.doi.org/10.1039/c5sc01141h.

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The solution-phase self-assembly or “polymerization” of discrete colloidal building blocks, such as “patchy” nanoparticles and multicompartment micelles, is attracting growing attention with respect to the creation of complex hierarchical materials.

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11

Wang, Anhe, Yang Yang, Xuehai Yan, Guanghui Ma, Shuo Bai, and Junbai Li. "Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro." RSC Advances 6, no. 74 (2016): 70064–71. http://dx.doi.org/10.1039/c6ra10743e.

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We demonstrate multicompartment silica-gelatin nanoparticles (MSGNs), using gelatin doped CaCO<sub>3</sub> particles as templates, with self-decomposability in response to body temperature as drug carriers for cancer therapy in vitro.

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12

Utech, Stefanie, Christian Scherer, and Michael Maskos. "Multifunctional, multicompartment polyorganosiloxane magnetic nanoparticles for biomedical applications." Journal of Magnetism and Magnetic Materials 321, no. 10 (2009): 1386–88. http://dx.doi.org/10.1016/j.jmmm.2009.02.043.

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13

Lengert, Ekaterina V., Semyon I. Koltsov, Jie Li, et al. "Nanoparticles in Polyelectrolyte Multilayer Layer-by-Layer (LbL) Films and Capsules—Key Enabling Components of Hybrid Coatings." Coatings 10, no. 11 (2020): 1131. http://dx.doi.org/10.3390/coatings10111131.

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Originally regarded as auxiliary additives, nanoparticles have become important constituents of polyelectrolyte multilayers. They represent the key components to enhance mechanical properties, enable activation by laser light or ultrasound, construct anisotropic and multicompartment structures, and facilitate the development of novel sensors and movable particles. Here, we discuss an increasingly important role of inorganic nanoparticles in the layer-by-layer assembly—effectively leading to the construction of the so-called hybrid coatings. The principles of assembly are discussed together with the properties of nanoparticles and layer-by-layer polymeric assembly essential in building hybrid coatings. Applications and emerging trends in development of such novel materials are also identified.

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14

Kim, Taehyung, Jeong Un Kim, Kyungjik Yang, et al. "Nanoparticle-Patterned Multicompartmental Chitosan Capsules for Oral Delivery of Oligonucleotides." ACS Biomaterials Science & Engineering 4, no. 12 (2018): 4163–73. http://dx.doi.org/10.1021/acsbiomaterials.8b00806.

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15

Suteewong, T., H. Sai, R. Hovden, et al. "Multicompartment Mesoporous Silica Nanoparticles with Branched Shapes: An Epitaxial Growth Mechanism." Science 340, no. 6130 (2013): 337–41. http://dx.doi.org/10.1126/science.1231391.

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16

Robello, Douglas R., Mark R. Mis, and Mridula Nair. "Micron-sized membrane reactors: Multicompartment semipermeable polymer particles containing palladium nanoparticles." Journal of Applied Polymer Science 132, no. 23 (2015): n/a. http://dx.doi.org/10.1002/app.42021.

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17

Angelov, Borislav, Angelina Angelova, Sergey K. Filippov, Markus Drechsler, Petr Štěpánek, and Sylviane Lesieur. "Multicompartment Lipid Cubic Nanoparticles with High Protein Upload: Millisecond Dynamics of Formation." ACS Nano 8, no. 5 (2014): 5216–26. http://dx.doi.org/10.1021/nn5012946.

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18

Uchman, Mariusz, Miroslav Štěpánek, Karel Procházka, et al. "Multicompartment Nanoparticles Formed by a Heparin-Mimicking Block Terpolymer in Aqueous Solutions." Macromolecules 42, no. 15 (2009): 5605–13. http://dx.doi.org/10.1021/ma9008115.

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19

de Bruyn Ouboter, Dirk, Thomas Schuster, Vijay Shanker, Markus Heim, and Wolfgang Meier. "Multicompartment micelle-structured peptide nanoparticles: A new biocompatible gene- and drug-delivery tool." Journal of Biomedical Materials Research Part A 102, no. 4 (2013): 1155–63. http://dx.doi.org/10.1002/jbm.a.34778.

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20

Kargari Aghmiouni, Delaram, and Sepideh Khoee. "Dual-Drug Delivery by Anisotropic and Uniform Hybrid Nanostructures: A Comparative Study of the Function and Substrate–Drug Interaction Properties." Pharmaceutics 15, no. 4 (2023): 1214. http://dx.doi.org/10.3390/pharmaceutics15041214.

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Анотація:

By utilizing nanoparticles to upload and interact with several pharmaceuticals in varying methods, the primary obstacles associated with loading two or more medications or cargos with different characteristics may be addressed. Therefore, it is feasible to evaluate the benefits provided by co-delivery systems utilizing nanoparticles by investigating the properties and functions of the commonly used structures, such as multi- or simultaneous-stage controlled release, synergic effect, enhanced targetability, and internalization. However, due to the unique surface or core features of each hybrid design, the eventual drug–carrier interactions, release, and penetration processes may vary. Our review article focused on the drug’s loading, binding interactions, release, physiochemical, and surface functionalization features, as well as the varying internalization and cytotoxicity of each structure that may aid in the selection of an appropriate design. This was achieved by comparing the actions of uniform-surfaced hybrid particles (such as core–shell particles) to those of anisotropic, asymmetrical hybrid particles (such as Janus, multicompartment, or patchy particles). Information is provided on the use of homogeneous or heterogeneous particles with specified characteristics for the simultaneous delivery of various cargos, possibly enhancing the efficacy of treatment techniques for illnesses such as cancer.

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21

Alqathami, Mamdooh, Anton Blencowe, Un Jin Yeo, Simon J. Doran, Greg Qiao, and Moshi Geso. "Novel Multicompartment 3-Dimensional Radiochromic Radiation Dosimeters for Nanoparticle-Enhanced Radiation Therapy Dosimetry." International Journal of Radiation Oncology*Biology*Physics 84, no. 4 (2012): e549-e555. http://dx.doi.org/10.1016/j.ijrobp.2012.05.029.

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22

Li, Shenzhen, Huijun Nie, Song Gu, Zhongqiang Han, Guang Han, and Wangqing Zhang. "Synthesis of Multicompartment Nanoparticles of ABC Miktoarm Star Polymers by Seeded RAFT Dispersion Polymerization." ACS Macro Letters 8, no. 7 (2019): 783–88. http://dx.doi.org/10.1021/acsmacrolett.9b00371.

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23

Zhu, Jiahua, Shiyi Zhang, Fuwu Zhang, Karen L. Wooley, and Darrin J. Pochan. "Hierarchical Assembly of Complex Block Copolymer Nanoparticles into Multicompartment Superstructures through Tunable Interparticle Associations." Advanced Functional Materials 23, no. 14 (2012): 1767–73. http://dx.doi.org/10.1002/adfm.201202323.

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24

Quintieri, Giada, Marco Saccone, Matthias Spengler, Michael Giese, and André H. Gröschel. "Supramolecular Modification of ABC Triblock Terpolymers in Confinement Assembly." Nanomaterials 8, no. 12 (2018): 1029. http://dx.doi.org/10.3390/nano8121029.

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The self-assembly of AB diblock copolymers in three-dimensional (3D) soft confinement of nanoemulsions has recently become an attractive bottom up route to prepare colloids with controlled inner morphologies. In that regard, ABC triblock terpolymers show a more complex morphological behavior and could thus give access to extensive libraries of multicompartment microparticles. However, knowledge about their self-assembly in confinement is very limited thus far. Here, we investigated the confinement assembly of polystyrene-block-poly(4-vinylpyridine)-block-poly(tert-butyl methacrylate) (PS-b-P4VP-b-PT or SVT) triblock terpolymers in nanoemulsion droplets. Depending on the block weight fractions, we found spherical microparticles with concentric lamella–sphere (ls) morphology, i.e., PS/PT lamella intercalated with P4VP spheres, or unusual conic microparticles with concentric lamella–cylinder (lc) morphology. We further described how these morphologies can be modified through supramolecular additives, such as hydrogen bond (HB) and halogen bond (XB) donors. We bound donors to the 4VP units and analyzed changes in the morphology depending on the binding strength and the length of the alkyl tail. The interaction with the weaker donors resulted in an increase in volume of the P4VP domains, which depends upon the molar fraction of the added donor. For donors with a high tendency of intermolecular packing, a visible change in the morphology was observed. This ultimately caused a shape change in the microparticle. Knowledge about how to control inner morphologies of multicompartment microparticles could lead to novel carbon supports for catalysis, nanoparticles with unprecedented topologies, and potentially, reversible shape changes by light actuation.

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25

Huo, Fei, Shentong Li, Quanlong Li, Yaqing Qu, and Wangqing Zhang. "In-Situ Synthesis of Multicompartment Nanoparticles of Linear BAC Triblock Terpolymer by Seeded RAFT Polymerization." Macromolecules 47, no. 7 (2014): 2340–49. http://dx.doi.org/10.1021/ma5002386.

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26

Khan, Habib, Shengli Chen, Heng Zhou, Shuang Wang, and Wangqing Zhang. "Synthesis of Multicompartment Nanoparticles of ABC Triblock Copolymers through Intramolecular Interactions of Two Solvophilic Blocks." Macromolecules 50, no. 7 (2017): 2794–802. http://dx.doi.org/10.1021/acs.macromol.7b00242.

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27

Hickey, Robert J., Qingjie Luo, and So-Jung Park. "Polymersomes and Multicompartment Polymersomes Formed by the Interfacial Self-Assembly of Gold Nanoparticles and Amphiphilic Polymers." ACS Macro Letters 2, no. 9 (2013): 805–8. http://dx.doi.org/10.1021/mz400301g.

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28

Li, Shentong, Xin He, Quanlong Li, Pengfei Shi, and Wangqing Zhang. "Synthesis of Multicompartment Nanoparticles of Block Copolymer through Two Macro-RAFT Agents Co-Mediated Dispersion Polymerization." ACS Macro Letters 3, no. 9 (2014): 916–21. http://dx.doi.org/10.1021/mz500466x.

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29

Kong, Weixin, Wei Jiang, Yutian Zhu, and Baohui Li. "Highly Symmetric Patchy Multicompartment Nanoparticles from the Self-Assembly of ABC Linear Terpolymers in C-Selective Solvents." Langmuir 28, no. 32 (2012): 11714–24. http://dx.doi.org/10.1021/la3014943.

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30

Khoee, Sepideh, Mohammad Mousazadeh, and Yousef Bagheri. "Effect of polyester/PEG mixed micelles composition on preparation of multicompartment nanoparticles: Influence of crystallinity on morphology." European Polymer Journal 87 (February 2017): 286–99. http://dx.doi.org/10.1016/j.eurpolymj.2016.12.028.

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31

Cui, Jie, Wei Li, and Wei Jiang. "Simulation study of co-assembly of ABC triblock copolymer/nanoparticle into multicompartment hybrids in selective solvent." Chinese Journal of Polymer Science 31, no. 9 (2013): 1225–32. http://dx.doi.org/10.1007/s10118-013-1323-7.

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32

Shi, Pengfei, Chengqiang Gao, Xin He, Pingchuan Sun, and Wangqing Zhang. "Multicompartment Nanoparticles of Poly(4-vinylpyridine) Graft Block Terpolymer: Synthesis and Application as Scaffold for Efficient Au Nanocatalyst." Macromolecules 48, no. 5 (2015): 1380–89. http://dx.doi.org/10.1021/acs.macromol.5b00021.

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33

Sheng, Yuping, Nan Yan, Jian An, and Yutian Zhu. "Multicompartment nanoparticles from the self-assembly of mixtures of ABC and AC block copolymers in C-selective solvents." Chemical Physics 441 (September 2014): 47–52. http://dx.doi.org/10.1016/j.chemphys.2014.07.005.

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34

Kwong, Gabriel A., Jaideep S. Dudani, Emmanuel Carrodeguas, Eric V. Mazumdar, Seyedeh M. Zekavat, and Sangeeta N. Bhatia. "Mathematical framework for activity-based cancer biomarkers." Proceedings of the National Academy of Sciences 112, no. 41 (2015): 12627–32. http://dx.doi.org/10.1073/pnas.1506925112.

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Анотація:

Advances in nanomedicine are providing sophisticated functions to precisely control the behavior of nanoscale drugs and diagnostics. Strategies that coopt protease activity as molecular triggers are increasingly important in nanoparticle design, yet the pharmacokinetics of these systems are challenging to understand without a quantitative framework to reveal nonintuitive associations. We describe a multicompartment mathematical model to predict strategies for ultrasensitive detection of cancer using synthetic biomarkers, a class of activity-based probes that amplify cancer-derived signals into urine as a noninvasive diagnostic. Using a model formulation made of a PEG core conjugated with protease-cleavable peptides, we explore a vast design space and identify guidelines for increasing sensitivity that depend on critical parameters such as enzyme kinetics, dosage, and probe stability. According to this model, synthetic biomarkers that circulate in stealth but then activate at sites of disease have the theoretical capacity to discriminate tumors as small as 5 mm in diameter—a threshold sensitivity that is otherwise challenging for medical imaging and blood biomarkers to achieve. This model may be adapted to describe the behavior of additional activity-based approaches to allow cross-platform comparisons, and to predict allometric scaling across species.

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35

Shi, Pengfei, Quanlong Li, Xin He, Shentong Li, Pingchuan Sun, and Wangqing Zhang. "A New Strategy To Synthesize Temperature- and pH-Sensitive Multicompartment Block Copolymer Nanoparticles by Two Macro-RAFT Agents Comediated Dispersion Polymerization." Macromolecules 47, no. 21 (2014): 7442–52. http://dx.doi.org/10.1021/ma501598k.

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36

Wang, Anhe, Yang Yang, Yanfei Qi, et al. "Fabrication of Mesoporous Silica Nanoparticle with Well-Defined Multicompartment Structure as Efficient Drug Carrier for Cancer Therapy in Vitro and in Vivo." ACS Applied Materials & Interfaces 8, no. 14 (2016): 8900–8907. http://dx.doi.org/10.1021/acsami.5b12031.

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37

Daubian, Davy, Jens Gaitzsch, and Wolfgang Meier. "Synthesis and complex self-assembly of amphiphilic block copolymers with a branched hydrophobic poly(2-oxazoline) into multicompartment micelles, pseudo-vesicles and yolk/shell nanoparticles." Polymer Chemistry 11, no. 6 (2020): 1237–48. http://dx.doi.org/10.1039/c9py01559k.

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A new PEO-b-PEHOx amphiphilic diblock copolymer was achieved which unlocked new complex self-assembled structures. Thanks to its hydrophobic oxazoline block with a long branched side chain, EHOx, various potent structures were obtained.

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38

Appelhans, Dietmar, Yang Zhou, Kehu Zhang, Silvia Moreno, Achim Temme, and Brigitte Voit. "Continuous Transformation from Membrane‐less Coacervates to Membranized Coacervates and Giant Vesicles: toward Multicompartmental Protocells with Complex (Membrane) Architectures." Angewandte Chemie, June 7, 2024. http://dx.doi.org/10.1002/ange.202407472.

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The membranization of membrane‐less coacervates paves the way for the exploitation of complex protocells with regard to structural and cell‐like functional behaviors. However, the controlled transformation from membranized coacervates to vesicles remains a challenge. This can provide stable (multi)phase and (multi)compartmental architectures through the reconfiguration of coacervate droplets in the presence of (bioactive) polymers, bio(macro)molecules and/or nanoobjects. Herein, we present a continuous protocell transformation from membrane‐less coacervates to membranized coacervates and, ultimately, to giant hybrid vesicles. This transformation process is orchestrated by altering the balance of non‐covalent interactions through varying concentrations of an anionic terpolymer, leading to dynamic processes such as spontaneous membranization of terpolymer nanoparticles at the coacervate surface, disassembly of the coacervate phase mediated by the excess anionic charge, and the redistribution of coacervate components in membrane. The diverse protocells during the transformation course provide distinct structural features and molecular permeability. Notably, the introduction of multiphase coacervates in this continuous transformation process signifies advancements toward the creation of synthetic cells with different diffusible compartments. Our findings emphasize the highly controlled continuous structural reorganization of coacervate protocells and represents a novel step toward the development of advanced and sophisticated synthetic protocells with more precise compositions and complex (membrane) structures.

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39

Appelhans, Dietmar, Yang Zhou, Kehu Zhang, Silvia Moreno, Achim Temme, and Brigitte Voit. "Continuous Transformation from Membrane‐less Coacervates to Membranized Coacervates and Giant Vesicles: toward Multicompartmental Protocells with Complex (Membrane) Architectures." Angewandte Chemie International Edition, June 7, 2024. http://dx.doi.org/10.1002/anie.202407472.

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Анотація:

The membranization of membrane‐less coacervates paves the way for the exploitation of complex protocells with regard to structural and cell‐like functional behaviors. However, the controlled transformation from membranized coacervates to vesicles remains a challenge. This can provide stable (multi)phase and (multi)compartmental architectures through the reconfiguration of coacervate droplets in the presence of (bioactive) polymers, bio(macro)molecules and/or nanoobjects. Herein, we present a continuous protocell transformation from membrane‐less coacervates to membranized coacervates and, ultimately, to giant hybrid vesicles. This transformation process is orchestrated by altering the balance of non‐covalent interactions through varying concentrations of an anionic terpolymer, leading to dynamic processes such as spontaneous membranization of terpolymer nanoparticles at the coacervate surface, disassembly of the coacervate phase mediated by the excess anionic charge, and the redistribution of coacervate components in membrane. The diverse protocells during the transformation course provide distinct structural features and molecular permeability. Notably, the introduction of multiphase coacervates in this continuous transformation process signifies advancements toward the creation of synthetic cells with different diffusible compartments. Our findings emphasize the highly controlled continuous structural reorganization of coacervate protocells and represents a novel step toward the development of advanced and sophisticated synthetic protocells with more precise compositions and complex (membrane) structures.

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40

Liu, Jianhang, Yingdi Lv, Xinghai Li, et al. "Magnetic‐optical dual functional Janus particles for the detection of metal ions assisted by machine learning." Smart Molecules, September 19, 2023. http://dx.doi.org/10.1002/smo.20230006.

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AbstractFunctional polymer microspheres have broad application prospects in various fields, such as metal ion detection, adsorption, separation, and controlled drug release. However, integrating different functions in a single microsphere system is a significant challenge in this field. In this work, we prepared multicompartmental emulsion droplets utilizing microfluidic technology. Fe3O4 magnetic nanoparticles were added to one of the compartments of the emulsion droplets as functional particles, and Janus microspheres were obtained after curing. Fluorescent probes enter the two compartments of the Janus microspheres by diffusion. The fluorescence changes of the microspheres were observed in situ and captured through a fluorescence microscope. The images are processed by image recognition software and a Python program. The “fingerprint” of the detected metal ions is obtained by dimensionality reduction of the data through Principal Component Analysis. We employ different algorithms to build Machine Learning models for predicting the metal ion species and concentration. The variation of fluorescence intensity of the three fluorescent probes and the corresponding R, G, and B channel values and time are used as descriptors. The results show that the Random Forest, K‐neighborhood (KNN), and Neural Network models demonstrated a better predicted effect with a variance (R2) greater than 0.9 and a smaller root mean square error; among them, the KNN model predicted the most accurate results.

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41

Chen, Hai, Xueer Han, Junlu Gao, et al. "Interfacial‐Design Mediated Construction of Hybrid Multicompartment Architectures with Layered Physicochemical Barriers for Separately Sequestration of Oxidation–Reduction Molecules and Their Redox Reaction Regulation." Small, March 12, 2025. https://doi.org/10.1002/smll.202412033.

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AbstractHybrid multicompartment artificial architectures, inherited from different compartmental systems, possess separate microenvironments that can perform different functions. Herein, a hybrid compartmentalized architecture via hybridizing ferritin nanocage (Fn) with non‐aqueous droplets using aminated‐modified amphiphilic gelatin (AGEL) is proposed, which enables the generation of compartmentalized emulsions with hybrid multicompartments. The resulting compartmentalized emulsions are termed “hybrasome”. Specifically, by chemically attaching ethylenediamine to gelatin, the programmed noncovalent docking of Fn‐AGEL nanoparticles is implemented and their interfacial self‐rearrangement generates hybrasome with layered physicochemical barriers. Confocal Laser Scanning Microscopy images show that Fn nanocages are deposited on the non‐aqueous droplets, separated by gelatin layers. Interfacial adsorption kinetics reveal that lower permeation and rearrangement rates of Fn are responsible for their double‐layered structure formation. By choosing oxidized iron nanoparticles and reductant carnosic acid (CA) as models, these two molecules are co‐encapsulated separately within the hybrasome, resulting in significant inhibition of the redox reaction. After structural destruction in the intestine, a redox reaction is triggered and leads to the Fe2+ redox products release, which generates a suitable valence state of iron element for cell absorption. Overall, this approach may open up an avenue for facile construction of hybrid compartmentalized architectures used to co‐encapsulate incompatible compounds separately and control the sequential release of targeted components.

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42

Kolanjiyil, Arun V., and Clement Kleinstreuer. "Nanoparticle Mass Transfer From Lung Airways to Systemic Regions—Part II: Multi-Compartmental Modeling." Journal of Biomechanical Engineering 135, no. 12 (2013). http://dx.doi.org/10.1115/1.4025333.

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This is the second article of a two-part paper, combining high-resolution computer simulation results of inhaled nanoparticle deposition in a human airway model (Kolanjiyil and Kleinstreuer, 2013, “Nanoparticle Mass Transfer From Lung Airways to Systemic Regions—Part I: Whole-Lung Aerosol Dynamics,” ASME J. Biomech. Eng., 135(12), p. 121003) with a new multicompartmental model for insoluble nanoparticle barrier mass transfer into systemic regions. Specifically, it allows for the prediction of temporal nanoparticle accumulation in the blood and lymphatic systems and in organs. The multicompartmental model parameters were determined from experimental retention and clearance data in rat lungs and then the validated model was applied to humans based on pharmacokinetic cross-species extrapolation. This hybrid simulator is a computationally efficient tool to predict the nanoparticle kinetics in the human body. The study provides critical insight into nanomaterial deposition and distribution from the lungs to systemic regions. The quantitative results are useful in diverse fields such as toxicology for exposure-risk analysis of ubiquitous nanomaterial and pharmacology for nanodrug development and targeting.

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Palomba, Francesco, Damiano Genovese, Luca Petrizza, Enrico Rampazzo, Nelsi Zaccheroni, and Luca Prodi. "Mapping heterogeneous polarity in multicompartment nanoparticles." Scientific Reports 8, no. 1 (2018). http://dx.doi.org/10.1038/s41598-018-35257-y.

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Kolanjiyil, Arun V., and Clement Kleinstreuer. "Nanoparticle Mass Transfer From Lung Airways to Systemic Regions—Part I: Whole-Lung Aerosol Dynamics." Journal of Biomechanical Engineering 135, no. 12 (2013). http://dx.doi.org/10.1115/1.4025332.

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This is a two-part paper describing inhaled nanoparticle (NP) transport and deposition in a model of a human respiratory tract (Part I) as well as NP-mass transfer across barriers into systemic regions (Part II). Specifically, combining high-resolution computer simulation results of inhaled NP deposition in the human airways (Part I) with a multicompartmental model for NP-mass transfer (Part II) allows for the prediction of temporal NP accumulation in the blood and lymphatic systems as well as in organs. An understanding of nanoparticle transport and deposition in human respiratory airways is of great importance, as exposure to nanomaterial has been found to cause serious lung diseases, while the use of nanodrugs may have superior therapeutic effects. In Part I, the fluid-particle dynamics of a dilute NP suspension was simulated for the entire respiratory tract, assuming steady inhalation and planar airways. Thus, a realistic airway configuration was considered from nose/mouth to generation 3, and then an idealized triple-bifurcation unit was repeated in series and parallel to cover the remaining generations. Using the current model, the deposition of NPs in distinct regions of the lung, namely extrathoracic, bronchial, bronchiolar, and alveolar, was calculated. The region-specific NP-deposition results for the human lung model were used in Part II to determine the multicompartmental model parameters from experimental retention and clearance data in human lungs. The quantitative, experimentally validated results are useful in diverse fields, such as toxicology for exposure-risk analysis of ubiquitous nanomaterial as well as in pharmacology for nanodrug development and targeting.

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Varshney, Kamya, Rupa Mazumder, Anjna Rani, Pratibha Pandey, and Malakapogu Ravindra babu. "Liquid Crystalline Lipid Nanoparticles: Emerging Trends and Applications in Skin Cancer." Pharmaceutical Nanotechnology 12 (August 30, 2024). http://dx.doi.org/10.2174/0122117385312450240816055942.

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Liquid crystalline lipid nanoparticles (LCNPs) represent a type of membrane-based nano-carriers formed through the self-assembly of lyotropic lipids. These lipids, such as unsaturated monoglycerides, phospholipids, and co-lipids, create liquid crystals or vesicles with an aqueous core enclosed by a natural or synthetic phospholipid bilayer upon exposure to an aqueous medium. Liquid crystalline lipid nanoparticles (LCNPs), akin to liposomes, have garnered significant attention as nanocarriers suitable for a diverse range of hydrophobic and hydrophilic molecules. Their notable structural advantage lies in a mono-channel network organization and the presence of multiple compartments, resulting in heightened encapsulation efficiency for various substances. Cubosomes, spongosomes, hexosomes, and multicompartment nanoparticles are examples of lipid nanocarriers with interior liquid crystalline structures that have recently gained a lot of interest as effective drug delivery systems. Additionally, LCNPs facilitate the sustained release of encapsulated compounds, including therapeutic macromolecules. This review delves into the structure of liquid crystalline lipid nanoparticles, explores preparation techniques, and outlines their applications in the context of skin cancer.

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Chen, Yifei, Jianbo Tan, and Liangliang Shen. "Seeded Raft Polymerization‐Induced Self‐assembly: Recent Advances and Future Opportunities." Macromolecular Rapid Communications, August 24, 2023. http://dx.doi.org/10.1002/marc.202300334.

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AbstractOver the past decade, polymerization‐induced self‐assembly (PISA) has fully proved its versatility for scale‐up production of block copolymer nanoparticles with tunable sizes and morphologies; yet, there are still some limitations. Recently, seeded PISA approaches combing PISA with heterogeneous seeded polymerizations have been greatly explored and are expected to overcome the limitations of traditional PISA. In this review, recent advances in seeded PISA that have expanded new horizons for PISA are highlighted including i) general considerations for seeded PISA (e.g., kinetics, the preparation of seeds, the selection of monomers), ii) morphological evolution induced by seeded PISA (e.g., from corona‐shell‐core nanoparticles to vesicles, vesicles‐to‐toroid, disassembly of vesicles into nanospheres), and iii) various well‐defined nanoparticles with hierarchical and sophisticated morphologies (e.g., multicompartment micelles, porous vesicles, framboidal vesicles, AXn‐type colloidal molecules). Finally, new insights into seeded PISA and future perspectives are proposed.This article is protected by copyright. All rights reserved

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Phan, Quoc Thang, Hu Zhang, Duy Anh Pham, et al. "Multicompartment Micro- and Nanoparticles Using Supramolecular Assembly of Core–Shell Bottlebrush Polymers." ACS Macro Letters, November 9, 2023, 1589–94. http://dx.doi.org/10.1021/acsmacrolett.3c00580.

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Turali‐Emre, E. Sumeyra, Ahmet E. Emre, Drew A. Vecchio, Usha Kadiyala, J. Scott VanEpps, and Nicholas A. Kotov. "Self‐Organization of Iron Sulfide Nanoparticles into Complex Multicompartment Supraparticles (Adv. Mater. 23/2023)." Advanced Materials 35, no. 23 (2023). http://dx.doi.org/10.1002/adma.202370166.

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Huo, Haohui, Jie Liu, Senthil Kannan, et al. "Multicompartment Nanoparticles Bearing Hydrophilic/Hydrophobic Subdomains by Self-Assembly of Star Polymers in Aqueous Solution." Macromolecules, December 16, 2020. http://dx.doi.org/10.1021/acs.macromol.0c02213.

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Huo, Haohui, Jing Zou, Shugui Yang, et al. "Multicompartment Nanoparticles by Crystallization‐Driven Self‐Assembly of Star Polymers: Combining High Stability and Loading Capacity." Macromolecular Rapid Communications, November 10, 2022, 2200706. http://dx.doi.org/10.1002/marc.202200706.

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