Готові списки джерел за темами / MUTANT SCORE

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Добірка наукової літератури з теми "MUTANT SCORE"

Автор: Grafiati

Опубліковано: 11 вересня 2023

Оновлено: 31 липня 2025

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Статті в журналах з теми "MUTANT SCORE"

Rupinder, Kaur* Sanjay Tyagi. "A NOVEL APPROACH TO DETECT EQUIVALENT MUTANTS USING CONTROL FLOW GRAPH." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 5, no. 7 (2016): 1070–77. https://doi.org/10.5281/zenodo.57991.

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Software testing verifies and validates software systems. Mutation testing is a testing procedure where mutants are created by seeding fault to the code. Test cases are exercised on these mutants to measure the adequacy given by mutation score. If the mutants are not killed, then either the test data is not sufficient or there is the presence of equivalent mutant, which is an undecidable problem. Equivalent mutant problem makes testing process more difficult and tedious. A technique has been proposed in this paper to detect equivalent mutants by observing RIP model and control flow graph of or

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Sugave, Shounak Rushikesh, Yogesh R. Kulkarni, and Balaso. "Multi-Objective Optimization Model and Hierarchical Attention Networks for Mutation Testing." International Journal of Swarm Intelligence Research 14, no. 1 (2023): 1–23. http://dx.doi.org/10.4018/ijsir.319714.

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Mutation testing is devised for measuring test suite adequacy by identifying the artificially induced faults in software. This paper presents a novel approach by considering multiobjectives-based optimization. Here, the optimal test suite generation is performed using the proposed water cycle water wave optimization (WCWWO). The best test suites are generated by satisfying the multi-objective factors, such as time of execution, test suite size, mutant score, and mutant reduction rate. The WCWWO is devised by a combination of the water cycle algorithm (WCA) and water wave optimization (WWO). Th

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Almahasheer, Arwa Ali, Amal Mahmoud, Hesham El-Komy, et al. "Novel Feather Degrading Keratinases from Bacillus cereus Group: Biochemical, Genetic and Bioinformatics Analysis." Microorganisms 10, no. 1 (2022): 93. http://dx.doi.org/10.3390/microorganisms10010093.

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In this study, five keratinolytic bacteria were isolated from poultry farm waste of Eastern Province, Saudi Arabia. The highest keratinase activity was obtained at 40–45 °C, pH 8–9, feather concentration 0.5–1%, and using white chicken feather as keratin substrate for 72 h. Enhancement of keratinase activity through physical mutagen UV radiation and/or chemical mutagen ethyl methanesulfonate (EMS) resulted in five mutants with 1.51–3.73-fold increased activity over the wild type. When compared with the wild type, scanning electron microscopy validated the mutants’ effectiveness in feather degr

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Xie, Yuancai, Yingmei Li, Linfeng Dong, Shifu Chen, and Jixian Liu. "A differential analysis of TCR repertoire between patients with EGFR-mutant and KRAS-mutant non–small-cell lung cancer." Journal of Clinical Oncology 41, no. 16_suppl (2023): e21012-e21012. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e21012.

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e21012 Background: T-cell receptor (TCR) repertoire could partially represent tumor micro-environment. EGFR and KRAS are common driver genes mutated and often mutually exclusive in non-small cell lung cancer (NSCLC). There’s a hypothesis that the immune system responds differently according to different mutations. Here we investigated the TCR features, including diversity, clonality, evenness and sequence similarity in EGFR and KRAS mutated NSCLC patients, to better understand the immune response in carcinogenesis. Methods: A total of 71 EGFR-mutant and 31 KRAS-mutant NSCLC tissue samples unde

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Yu, Guangyang, Ying Pang, Mythili Merchant, et al. "Tumor Mutation Burden, Expressed Neoantigens and the Immune Microenvironment in Diffuse Gliomas." Cancers 13, no. 23 (2021): 6092. http://dx.doi.org/10.3390/cancers13236092.

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Background: A consistent correlation between tumor mutation burden (TMB) and tumor immune microenvironment has not been observed in gliomas as in other cancers. Methods: Driver germline and somatic mutations, TMB, neoantigen, and immune cell signatures were analyzed using whole exome sequencing (WES) and transcriptome sequencing of tumor and WES of matched germline DNA in a cohort of 66 glioma samples (44 IDH-mutant and 22 IDH-wildtype). Results: Fourteen samples revealed a hypermutator phenotype (HMP). Eight pathogenic (P) or likely pathogenic (LP) germline variants were detected in 9 (19%) p

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Karsy, Michael, Jian Guan, and L. Eric Huang. "Prognostic role of mitochondrial pyruvate carrier in isocitrate dehydrogenase–mutant glioma." Journal of Neurosurgery 130, no. 1 (2018): 56–66. http://dx.doi.org/10.3171/2017.9.jns172036.

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OBJECTIVEGliomas are one of the most common types of primary brain tumors. Recent studies have supported the importance of key genetic alterations, including isocitrate dehydrogenase (IDH) mutations and 1p19q codeletion, in glioma prognosis. Mutant IDH produces 2-hydroxyglutarate from α-ketoglutarate, a key metabolite of the Krebs cycle. The mitochondrial pyruvate carrier (MPC) is composed of MPC1 and MPC2 subunits and is functionally essential for the Krebs cycle. The authors sought to explore the impact of MPC1 and MPC2 expression on patient prognosis.METHODSGenomic and clinical data in pati

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Guimarães-Souza, Nadia Karina, Liliya Marsovna Yamaleyeva, Baisong Lu, Ana Claudia Mallet de Souza Ramos, Colin Edward Bishop, and Karl Erik Andersson. "Superoxide overproduction and kidney fibrosis: a new animal model." Einstein (São Paulo) 13, no. 1 (2015): 79–88. http://dx.doi.org/10.1590/s1679-45082015ao3179.

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Objective To establish whether the mutation in the Immp2L gene induces renal fibrosis and whether aging exacerbates renal morphology in mice. Methods Female mutant mice with mutation in the inner mitochondrial membrane peptidase 2-like protein at 3 and 18 months of age were used. Renal fibrosis was analyzed using classic fibrosis score, Masson’s trichrome staining, and analysis of profibrotic markers using real time polymerase chain reaction (superoxide dismutase 1, metalloproteinase-9, erythropoietin, transforming growth factor beta), and immunostaining (fibroblasts and Type IV collagen). Oxi

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Senecal, Justin Bruni, Yasmine Madan, Rabia Tahir, et al. "External Validation of the JAKPOT Score for Diagnosing JAK2-Positive Erythrocytosis: A Retrospective Cohort Study." Journal of Clinical Medicine 14, no. 15 (2025): 5173. https://doi.org/10.3390/jcm14155173.

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Background/Objectives: Erythrocytosis is a common laboratory abnormality affecting approximately 4% of males and 0.4% of females. The JAKPOT score was recently developed to differentiate primary from secondary erythrocytosis without molecular testing. JAKPOT+ patients meet any of the following criteria: erythrocytes > 6.45 × 1012/L, platelets > 350 × 109/L, or neutrophils > 6.2 × 109/L. We aimed to validate this score and identify predictors of JAK2-positive erythrocytosis in a retrospective cohort. Methods: We identified 213 patients (50 female, mean age 57 years) with undifferentiat

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He, Qiong, Yamin Li, Xihong Zhou, et al. "The combination of fibrinogen concentrations and the platelet-to-lymphocyte ratio predicts survival in patients with advanced lung adenocarcinoma treated with EGFR-TKIs." Journal of International Medical Research 49, no. 4 (2021): 030006052110040. http://dx.doi.org/10.1177/03000605211004021.

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ObjectiveThis study aimed to identify a predictive marker of response to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR-mutant advanced lung adenocarcinoma.MethodsA cohort of 190 patients with EGFR-mutant advanced lung adenocarcinoma was analyzed. Receiver operating characteristic curve analysis was used to evaluate the optimal cutoffs for fibrinogen levels, the neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR) for predicting progression-free survival (PFS). Univariate and multivariate survival analyses were performe

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Boucai, Laura, Venkatraman Seshan, Michelle Williams, et al. "Characterization of Subtypes of BRAF-Mutant Papillary Thyroid Cancer Defined by Their Thyroid Differentiation Score." Journal of Clinical Endocrinology & Metabolism 107, no. 4 (2021): 1030–39. http://dx.doi.org/10.1210/clinem/dgab851.

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Abstract Context The BRAFV600E mutation has been associated with more advanced clinical stage in papillary thyroid cancer (PTC) and decreased responsiveness to radioiodine (RAI). However, some BRAF mutant PTCs respond to RAI and have an indolent clinical behavior suggesting the presence of different subtypes of BRAF mutant tumors with distinct prognosis. Objective To characterize the molecular and clinical features of 2 subtypes of BRAF-mutant PTCs defined by their degree of expression of iodine metabolism genes. Design 227 BRAF-mutant PTCs from the Cancer Genome Atlas Thyroid Cancer study wer

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Більше джерел

Дисертації з теми "MUTANT SCORE"

YADAV, TRILOCAAN. "MINIMIZING AND OPTIMIZING THE SOLUTION SPACE OF TEST DATA." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18828.

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In the software development lifecycle (SDL), testing of software is the most stressful and exhausting operation which consumes lots of time. Every aspect of software is very hard to test. Consequently, in recent times some automatic data generation research methods were added to reduce the time expended during the software testing. And the solution space of the automated generated test data is very large. It is not easy to check all the test data which is generated because it is time consuming, forces to check whole solution space of automated generated test data. We present in this paper demo

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Книги з теми "MUTANT SCORE"

Wegele, Peter. Max Steiner. The Rowman & Littlefield Publishing Group, 2014. https://doi.org/10.5040/9798881815479.

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Max Steiner is one of the greatest—not to mention most prolific—composers of the Golden Age of Hollywood. The winner of three Academy Awards, Steiner’s credits include King Kong, The Informer, Gone with the Wind, Now, Voyager, Since You Went Away, Johnny Belinda, and The Caine Mutiny. Though known for timeless melodies that symbolize the glamor of Hollywood’s Golden Age, Steiner has also been hailed as a film scoring pioneer. In Max Steiner: Composing, Casablanca, and the Golden Age of Film Music, Peter Wegele unveils the man behind dozens of memorable scores, offering a portrait of the compos

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Jaques, Tony. Dictionary of Battles and Sieges. Greenwood, 2006. http://dx.doi.org/10.5040/9798216190738.

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Lead Reviewer: Dr. Daniel Coetzee, Independent Scholar, London, UK Review Board: Jeremy Black, University of Exeter, UK Dr. Frances F. Berdan, Professor of Anthropology, California State University, San Bernardino David A. Graff, Associate Professor, Department of History, Kansas State University Dr. Kevin Jones, University College London Dr. John Laband, Wilfrid Laurier University, Waterloo, Ontario, Canada Dr. Carter Malkasian, Center for Naval Analysis Mr. Toby McLeod, Lecturer in Modern History, University of Birmingham, UK Dr. Tim Moreman, Independent Scholar, London, UK Professor Bill Na

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Частини книг з теми "MUTANT SCORE"

Saif, Abdulwahid, Aref Al-Shamiri, and Abdulnour Shaher. "Development of new bread wheat resistant mutants for Ug99 rust disease (Puccinia graminis f. sp. tritici)." In Mutation breeding, genetic diversity and crop adaptation to climate change. CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0032.

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Abstract M<sub>3</sub> derived mutants from two bread wheat varieties, namely, 'Giza 186' and 'Saha 93', were screened for resistance to the rust Ug99 at two locations in Njoro (Kenya) and in Tihama (Yemen). At Tihama, two mutants of 'Giza 186' (G-M2-2010-1-28 and G-M2-2010-41-52) and four mutants of 'Saha 93' (S-M2-2010-16-12, S-M2-2010-21-13, S-M2-2010-22-14 and S-M2-2010-27-15) were seen to be resistant at both seedling and adult stages while their parents were resistant at seedling stage and susceptible at adult stage. In Kenya, the resistance score of the mutants was slightly different fr

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Singh, Sarvjeet, S. R. Sharma, R. K. Gill, and Shiv Kumar. "Induced variation for post-emergence herbicide tolerance in lentil." In Mutation breeding, genetic diversity and crop adaptation to climate change. CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0022.

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Abstract Lentil (Lens culinaris L. Medik.) is an important cool-season food legume but is a poor competitor to weeds because of a slow early growth rate. If weeds are left uncontrolled, they can reduce yield by up to 50%. Sensitivity of lentil to post-emergence herbicides warrants development of herbicide-tolerant cultivars. In the absence of natural variability, mutation breeding is a powerful tool to create variability for desired traits. Thus, 1000 seeds of a lentil genotype, LL1203, were exposed to gamma radiation (300 Gy, <sup>60</sup>Co) with the objective to induce herbicide tolerance.

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Rojas-Chacón, José Andrés, Fabián Echeverría-Beirute, and Andrés Gatica-Arias. "Evaluation of Coffee (Coffea arabica L. var. Catuaí) Tolerance to Leaf Rust (Hemileia vastatrix) Using Inoculation of Leaf Discs Under Controlled Conditions." In Mutation Breeding in Coffee with Special Reference to Leaf Rust. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-67273-0_17.

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AbstractCoffee leaf rust (CLR), caused by the obligate biotrophic fungus Hemileia vastatrix, is considered one of the most devastating diseases of Arabica coffee. The use of leaf rust resistant or tolerant coffee varieties is a critical component for effective management of this disease at the farm level. Conventional breeding of Arabica coffee for leaf rust resistance requires many years of breeding and field-testing. Induced mutagenesis is an effective tool to increase genetic variability and generate new alleles with potential benefit for addressing abiotic and biotic stresses such as leaf

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Noordin, Norazlina, Affrida Abu Hassan, Anis Nadia Mohd Faisol Mahadevan, Zaiton Ahmad, and Sakinah Ariffin. "Lab-Based Screening Using Hydroponic System for the Rapid Detection of Fusarium Wilt TR4 Tolerance/Resistance of Banana." In Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64915-2_6.

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AbstractField-based screening and evaluation of banana plant tolerance or resistance to Fusarium oxysporum f. sp. cubense (Foc) Tropical Race 4 (TR4) or also known as Fusarium wilt TR4 is ideal though not always feasible. Alternatively, screening of banana plantlets at lab-stage seems to be an effective method for early detection of Foc TR4 tolerance. We present a simple hydroponic system, that allows plant to grow in a water-based condition. The system has two layers, the upper layer is a tray that has holes for plantlets to be placed where the root system is supported using an inert medium s

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Kovacs, Anita. "Citizenship against democracy? Consequences of un-muting Hungarians beyond the borders on the EU’s rule of law crisis." In Standing Up for the Voiceless? Presses universitaires Saint-Louis Bruxelles, 2025. https://doi.org/10.4000/147uv.

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In the context of the EU’s rule of law crisis, peripherical situations which barely fall within the scope of EU law despite their EU-sensitive impact cast a new light on the limits of EU action vis-à-vis Member State discretion. This discretion amounts to abuse in the case of the Hungarian electorate being shaped in a way to consolidate Fidesz’s power through the un-muting of “Hungarians beyond the borders”. According to Hungarian law, all Hungarians living in neighbouring states are entitled to preferential naturalisation without any requirement of residency in Hungary or proof of Hungarian d

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Kondratenko, Serhii, and Yurii Tkalych. "EXPEDIENCE OF USING SCORING ASSESSMENT OF QUALITY TRAITS IN LEAF LETTUCE BREEDING." In Traditional and innovative scientific research: domestic and foreign experience. Publishing House “Baltija Publishing”, 2024. http://dx.doi.org/10.30525/978-9934-26-436-8-7.

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A significant reserve for increasing the efficiency of mutational breeding of lettuce (Lactuca sativa L. var. secalina) is the use of score (code) scales to assess the characteristics of the manifestation of quality traits that cannot be determined in physical units of measurement. The purpose of the experimental work is to establish the effect of a mutagenic factor (γ-irradiation) on the formation of qualitative traits that determine the phenotype of the leaf blade and to study the correlation between their manifestation and the manifestation of selective value quantitative traits in the crea

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Unissa, Ameeruddin Nusrath, and Luke Elizabeth Hanna. "Dissection of HIV-1 Protease Subtype B Inhibitors Resistance Through Molecular Modeling Approaches." In Big Data Analytics in HIV/AIDS Research. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3203-3.ch007.

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Protease (PR) is an important enzyme required for the posttranslational processing of the viral gene products of type-1 human immunodeficiency virus (HIV-1). Protease inhibitors (PI) act as competitive inhibitors that bind to the active site of PR. The I84V mutation contributes resistance to multiple PIs, and structurally, this mutation affects both sides of the enzyme active site. In order to get insights about this major resistance site to PR inhibitors using in silico approaches, in this chapter, the wild-type (WT) and mutant (MT) I84V of PR were modeled and docked with all PR inhibitors: A

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Faber, Anthony C. "Aims and Scope of the Volume." In Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-12-822833-3.09986-1.

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Bonavida, Benjamin. "Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy”." In Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-12-822833-3.09987-3.

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Silver, Lee M. "Genetic Markers." In Mouse Genetics Concepts and Applications. Oxford University PressNew York, NY, 1995. http://dx.doi.org/10.1093/oso/9780195075540.003.0008.

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Abstract Linkage analysis can only be performed on loci that are polymorphic with two or more distinguishable alleles. Naturally occurring polymorphic loci with clear single-gene effects are rarely observed in wild animal populations. In the laboratory, however, it is possible to identify and breed animals with mutations at many different loci (see Chapter 6). Over the last 90 years, thousands of independent mouse mutations have been characterized in various laboratories. In fact, as discussed previously, a primary reason for the initial choice of the mouse as an experimental genetic system wa

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Тези доповідей конференцій з теми "MUTANT SCORE"

Masotti, Cibele, Filipe F. Santos, Anamaria A. Camargo, and Pedro A. F. Galante. "Abstract B65: Measuring intratumoral heterogeneity with a mutant-allele frequency score across distinct cancer types." In Abstracts: AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; São Paulo, Brazil. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1557-3265.tcm17-b65.

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Ferreira, Matheus, Lincoln Costa, and Francisco Carlos Souza. "Search-based Test Data Generation for Mutation Testing: a tool for Python programs." In Escola Regional de Engenharia de Software. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/eres.2020.13722.

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Test data generation for mutation testing consists of identifying a set of inputs that maximizes the number of mutants killed. Mutation Testing is an excellent test criterion for detecting faults and measuring the effectiveness of test data sets. However, it is not widely used in practice due to the cost and complexity to perform some activities as generating test data. Although test suites can be produced and selected manually by a tester this practice is susceptible to errors and tools are needed to facilitate it. Several tools have been developed to automate mutation testing, but, only a fe

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Hecht, David, Mars Cheung, and Gary B. Fogel. "Docking scores and QSAR using evolved neural networks for the Pan-inhibition of wild-type and mutant PfDHFR by cycloguanil derivatives." In 2009 IEEE Congress on Evolutionary Computation (CEC). IEEE, 2009. http://dx.doi.org/10.1109/cec.2009.4982957.

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Gruber, Joshua J., Anosheh Afghahi, Alyssa Hatton, et al. "Abstract PD10-12: Genomic analysis from the talazoparib beyond BRCA clinical trial: Homologous recombination (HR) deficiency scores, loss-of-heterozygosity and mutations in non-BRCA1/2 mutant tumors with other HR mutations." In Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.sabcs20-pd10-12.

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Звіти організацій з теми "MUTANT SCORE"

Nikbin, Danial, and Yvan Labiche. A Consolidated List of FSM Mutation Operators. Carleton University. Department of Systems and Computer Engineering., 2024. https://doi.org/10.22215/crw/24p5021.

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Mutation analysis is extensively used for the comparison of state-based testing methods that work from a finite state machine (FSM); It consists in seeding faults in the FSM model using mutation operators, one fault at a time, executing already constructed test suites on the correct FSM and the mutated FSMs and comparing executions to identify proportions of mutants revealed by test suites, a.k.a. the mutation score. Although a common experimental practice, there is still a lot to discover about FSM mutation operators so that we can adequately rely on experimental results that employ them, sta

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Morrison, Mark, and Joshuah Miron. Molecular-Based Analysis of Cellulose Binding Proteins Involved with Adherence to Cellulose by Ruminococcus albus. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7695844.bard.

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At the beginning of this project, it was clear that R. albus adhered tightly to cellulose and its efficient degradation of this polysaccharide was dependent on micromolar concentrations of phenylacetic acid (PAA) and phenylpropionic acid (PPA). The objectives for our research were: i) to identify how many different kinds of cellulose binding proteins are produced by Ruminococcus albus; ii) to isolate and clone the genes encoding some of these proteins from the same bacterium; iii) to determine where these various proteins were located and; iv) quantify the relative importance of these proteins

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