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Добірка наукової літератури з теми "N-chlorotaurine"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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Статті в журналах з теми "N-chlorotaurine"

1

Nagl, Markus, Andreas Gruber, Anita Fuchs, et al. "Impact of N-Chlorotaurine on Viability and Production of Secreted Aspartyl Proteinases of Candida spp." Antimicrobial Agents and Chemotherapy 46, no. 6 (2002): 1996–99. http://dx.doi.org/10.1128/aac.46.6.1996-1999.2002.

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ABSTRACT N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.

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2

Kuzminykh, S. S., and O. V. Makarenko. "Pharmacoeconomic Analysis of N-Chlorotaurine Infusion Therapy in the Treatment of Patients with Peritonitis." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 5 (2022): 114–18. http://dx.doi.org/10.26693/jmbs07.05.114.

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Peritonitis is the main cause of death in patients with acute surgical diseases of the abdominal cavity. The average mortality rate from disseminated forms is currently 30%. In complications of multiple organ failure and infectious-toxic shock, as well as in postoperative peritonitis in elderly patients, the lethality rate can reach 40%–70%. Thus, this disease is one of the most pressing medical, biological and economic problems of our time. The purpose of the study was to perform pharmacoeconomic analysis of peritonitis treatment by medical technology using N-chlorotaurine in comparison with

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3

Nagl, Markus, Michael W. Hess, Kristian Pfaller, Paul Hengster, and Waldemar Gottardi. "Bactericidal Activity of MicromolarN-Chlorotaurine: Evidence for Its Antimicrobial Function in the Human Defense System." Antimicrobial Agents and Chemotherapy 44, no. 9 (2000): 2507–13. http://dx.doi.org/10.1128/aac.44.9.2507-2513.2000.

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ABSTRACT N-Chlorotaurine, the main representative of long-lived oxidants found in the supernatant of stimulated granulocytes, has been investigated systematically with regard to its antibacterial activity at different physiological concentrations for the first time.N-Chlorotaurine (12.5 to 50 μM) demonstrated a bactericidal effect i.e., a 2 to 4 log10 reduction in viable counts, after incubation at 37°C for 6 to 9 h at pH 7.0, which effect was significantly enhanced in an acidic milieu (at pH 5.0), with a 3 to 4 log10 reduction after 2 to 3 h. Moreover, bacteria were attenuated after being inc

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4

Kowalczyk, Kacper, Débora C. Coraça-Huber, Walter Wille-Kollmar, Michael Berktold, and Markus Nagl. "Activity of N-Chlorotaurine against Periodontal Pathogens." International Journal of Molecular Sciences 25, no. 15 (2024): 8357. http://dx.doi.org/10.3390/ijms25158357.

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Dental plaque bacteria play an important role in the pathogenicity of periodontitis and peri-implantitis. Therefore, antimicrobial agents are one means of treatment. N-chlorotaurine (NCT) as an endogenous well-tolerated topical antiseptic could be of advantage for this purpose. Accordingly, its microbicidal activity against some dental plaque bacteria was investigated at therapeutic concentrations in vitro. In quantitative killing assays, the activity of NCT against planktonic bacteria and against biofilms grown for 48 h on implantation screws was tested. Electron microscopy was used to demons

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5

Neher, Andreas, Markus Nagl, Anneliese Schrott-Fischer, et al. "N-Chlorotaurine, a Novel Endogenous Antimicrobial Agent." Archives of Otolaryngology–Head & Neck Surgery 127, no. 5 (2001): 530. http://dx.doi.org/10.1001/archotol.127.5.530.

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6

Fürnkranz, Ursula, Markus Nagl, Waldemar Gottardi, Martina Köhsler, Horst Aspöck, and Julia Walochnik. "Cytotoxic Activity of N-Chlorotaurine on Acanthamoeba spp." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 470–76. http://dx.doi.org/10.1128/aac.00715-07.

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ABSTRACT Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis (AK), which mainly occurs in contact lens wearers, and of skin lesions, granulomatous amoebic encephalitis (GAE), and disseminating diseases in the immunocompromised host. AK therapy is complex and irritating for the eye, skin lesions are difficult to treat, and there is no effective treatment for GAE. Therefore, new anti-Acanthamoeba drugs are needed. We investigated the anti-Acanthamoeba activity of N-chlorotaurine (NCT), an endogenous mild antiseptic. It was shown that NCT has amoebicidal qualities, both in phosph

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7

Gottardi, W., and M. Nagl. "N-chlorotaurine, a natural antiseptic with outstanding tolerability." Journal of Antimicrobial Chemotherapy 65, no. 3 (2010): 399–409. http://dx.doi.org/10.1093/jac/dkp466.

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8

Liu, Zheng-Xian, and Irwin Fridovich. "Negative chemotaxis in Cytophaga johnsonae." Canadian Journal of Microbiology 42, no. 5 (1996): 515–18. http://dx.doi.org/10.1139/m96-069.

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Chemotaxis, both positive and negative, has been extensively studied in flagellated bacteria, such as Escherichia coli and Salmonella typhimurium, but not in gliding bacteria. The rapidly motile gliding bacterium Cytophaga johnsonae has been seen to be repelled by H2O2, OCl−, and N-chlorotaurine, as well as by low pH. Its response to H2O2 was eliminated by catalase. Nalidixic acid at 200 μM, which inhibits the growth but not the motility of C. johnsonae, did not interfere with its negative chemotactic response to H2O2, whereas sodium phosphate at 10 mM, which inhibits motility, did so. Cytopha

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9

Kusminyh, S. S., O. V. Ishchenko, I. Yu Stetsenko, G. I. Titov, and O. V. Makarenko. "MICROBIOLOGICAL REASONING OF N-CHLOROTAURINE USE IN SECONDARY PERITONITIS." Bulletin of Problems Biology and Medicine 2, no. 1 (2021): 184. http://dx.doi.org/10.29254/2077-4214-2021-2-160-184-188.

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10

Huber, Johann, Petra Winter, Waldemar Gottardi, Sabine Scholl-Bürgi, Wolfgang Prokop, and Markus Nagl. "Tolerability of N-chlorotaurine in the bovine mammary gland." Journal of Dairy Research 75, no. 2 (2008): 248–56. http://dx.doi.org/10.1017/s0022029908003233.

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Анотація:

N-Chlorotaurine (NCT) is a promising endogenous agent for topical treatment of infections. We tested the tolerability and pharmakokinetics of NCT in the bovine mammary glands in a phase 1 study. Three concentrations of NCT in water (0·1%, 1·0%, 2·0%) were administered intramammarily in each of two cows. Into two quarters of the udder 100 ml NCT was injected into each twice daily for 5 d, while 0·9% NaCl was injected into the other two quarters in a randomized and blinded manner. Samples of milk were taken to determine the number of leucocytes and the activity of NCT, and samples of urine and b

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