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Статті в журналах з теми "Nanofiber wound dressings":
1
Heunis, Tiaan D. J., Carine Smith, and Leon M. T. Dicks. "Evaluation of a Nisin-Eluting Nanofiber Scaffold To Treat Staphylococcus aureus-Induced Skin Infections in Mice." Antimicrobial Agents and Chemotherapy 57, no. 8 (June 3, 2013): 3928–35. http://dx.doi.org/10.1128/aac.00622-13.
Анотація:
ABSTRACTStaphylococcus aureusis a virulent pathogen and a major causative agent of superficial and invasive skin and soft tissue infections (SSSTIs). Antibiotic resistance inS. aureus, among other bacterial pathogens, has rapidly increased, and this is placing an enormous burden on the health care sector and has serious implications for infected individuals, especially immunocompromised patients. Alternative treatments thus need to be explored to continue to successfully treat infections caused byS. aureus, including antibiotic-resistant strains ofS. aureus. In this study, an antimicrobial nanofiber wound dressing was generated by electrospinning nisin (Nisaplin) into poly(ethylene oxide) and poly(d,l-lactide) (50:50) blend nanofibers. Active nisin diffused from the nanofiber wound dressings for at least 4 daysin vitro, as shown by consecutive transfers onto plates seeded with strains of methicillin-resistantS. aureus(MRSA). The nisin-containing nanofiber wound dressings significantly reducedS. aureusXen 36 bioluminescencein vivoand viable cell numbers in a murine excisional skin infection model. The bacterial burden of wounds treated with nisin-containing nanofiber wound dressings was 4.3 × 102CFU/wound, whereas wounds treated with control nanofiber wound dressings had 2.2 × 107CFU/wound on the last day of the trial (day 7). Furthermore, the wound dressings stimulated wound closure of excisional wounds, and no adverse effects were observed by histological analysis. Nisin-containing nanofiber wound dressings have the potential to treatS. aureusskin infections and to potentially accelerate wound healing of excisional wounds.
2
Shabunin, Anton, Vladimir Yudin, Irina Dobrovolskaya, Evgeny Zinovyev, Viktor Zubov, Elena Ivan’kova, and Pierfrancesco Morganti. "Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications." Cosmetics 6, no. 1 (March 1, 2019): 16. http://dx.doi.org/10.3390/cosmetics6010016.
Анотація:
An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds.
3
Schulte-Werning, Laura Victoria, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Nataša Škalko-Basnet, and Ann Mari Holsæter. "Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning." Pharmaceutics 13, no. 9 (September 21, 2021): 1527. http://dx.doi.org/10.3390/pharmaceutics13091527.
Анотація:
An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM), beta-glucan (βG) and chitosan (CHI), of which βG and CHI are active nanofiber-forming biopolymers isolated from the cell walls of Saccharomyces cerevisiae and from shrimp shells, respectively. To evaluate the effect of each active ingredient on the nanofibers’ morphological features and bioactivity, nanofibers with both βG and CHI, only βG, only CHI and only copolymers, polyethylene oxide (PEO) and hydroxypropylmethylcellulose (HPMC) were fabricated. All four nanofiber formulations were also prepared with 1% CAM. The needle-free NanospiderTM technique allowed for the successful production of defect-free nanofibers containing all three active ingredients. The CAM-containing nanofibers had a burst CAM-release and a high absorption capacity. Nanofibers with all active ingredients (βG, CHI and CAM) showed a concentration-dependent anti-inflammatory activity, while maintaining the antimicrobial activity of CAM. The promising anti-inflammatory properties, together with the high absorption capacity and antimicrobial effect, make these multifunctional nanofibers promising as dressings in local treatment of infected and exuding wounds, such as burn wounds.
4
Amer, Somaya, Noha Attia, Samir Nouh, Mahmoud El-Kammar, Ahmed Korittum, and Howaida Abu-Ahmed. "Fabrication of sliver nanoparticles/polyvinyl alcohol/gelatin ternary nanofiber mats for wound healing application." Journal of Biomaterials Applications 35, no. 2 (May 22, 2020): 287–98. http://dx.doi.org/10.1177/0885328220927317.
Анотація:
Purpose In this study, we aimed to determine the regenerative and antimicrobial impact of the electrospun nanofiber mats, with/without silver nanoparticles (AgNPs), on full-thickness skin wounds in rabbits. Methods Polyvinyl alcohol was combined with gelatin to provide biocompatible electrospun binary nanofiber mats. AgNPs were added to the polyvinyl alcohol/gelatin mixture to obtain ternary nanofiber-AgNPs mats. Binary and ternary nanofiber mats were characterized by scanning electron microscopy before being applied as wound dressings in vivo. Subsequently, wound healing was evaluated. Results Both nanofiber/nanofiber-AgNPs mats improved the microscopic quality of the healed skin, albeit without obvious acceleration of the healing rate. As well, both types of nanofiber mats were able to combat microbial invasion into the wound bed. Conclusions Both binary polyvinyl alcohol/gelatin and ternary polyvinyl alcohol/gelatin/AgNPs nanofiber mats developed in the present study depicted similar regenerative and antimicrobial potential when applied as full-thickness wound dressing. However, in comparison to the binary nanofiber mats, no obvious synergistic effect was observed after loading nanofibers with AgNPs.
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Mousavi, Seyyed-Mojtaba, Zohre Mousavi Nejad, Seyyed Alireza Hashemi, Marjan Salari, Ahmad Gholami, Seeram Ramakrishna, Wei-Hung Chiang, and Chin Wei Lai. "Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review." Membranes 11, no. 9 (September 13, 2021): 702. http://dx.doi.org/10.3390/membranes11090702.
Анотація:
Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.
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Ghorbanzadeh Sheish, Shahnaz, Rahmatollah Emadi, Mehdi Ahmadian, Sorour Sadeghzade, and Fariborz Tavangarian. "Fabrication and Characterization of Polyvinylpyrrolidone-Eggshell Membrane-Reduced Graphene Oxide Nanofibers for Tissue Engineering Applications." Polymers 13, no. 6 (March 16, 2021): 913. http://dx.doi.org/10.3390/polym13060913.
Анотація:
One of the best methods to prevent wound infection and speed up wound healing is wound dressing based on nanofiber–polymer scaffolds, which have acceptable antimicrobial performance and appropriate skin regeneration capabilities. In this paper, the electrospinning method was applied to synthesize the polyvinylpyrrolidone-acrylic acid hydrogel (PVPA)–eggshell membrane (ESM)–reduced graphene oxide (rGO) nanosheets nanocomposite dressings with different reduced graphene oxide contents (0, 0.5, 1, and 2 wt.%). Thus, smooth nanofibers were fabricated, including a high amount of rGO, which reduced the fiber diameter. Based on the results, rGO played an important role in water impermeability. The results showed that by increasing the rGO concentration from 0.5 to 2 wt%, the contact angle value increased persistently. Results showed that compared to PVPA–ESM, the mechanical strength and strain of PVPA–ESM/1 wt% rGO significantly enhanced 28% and 23%, respectively. Incorporation of 1 wt% rGO enhanced swelling ratio from 875% for PVPA-ESM to 1235% after 420 min, while increasing the rGO to 2 wt% increased the degradation rate of the composites. According to the in vitro cell culture studies, PVPA-ESM wound dressings with 0.5–1 wt% rGO content enhanced PC12 cell viability compared to the wound dressings without rGO nanosheets. Generally, rGO–loaded PVPA-ESM nanofiber wound dressing can be considered as a potential candidate to be used in skin regeneration applications.
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Liu, Qing, Liping Yang, and Qingrong Peng. "Study on scar repair and wound nursing of chitosan-based composite electrospun nanofibers in first aid of burn." Materials Express 11, no. 8 (August 1, 2021): 1420–27. http://dx.doi.org/10.1166/mex.2021.2041.
Анотація:
Bacterial infection and oxidative stress are serious complications in emergency burn patients, as the increase of oxygen free radicals in burn wounds can aggravate vascular endothelial cell injury, make the wounds ischemic and hypoxic, and delay wound healing. Traditional dressings cannot meet the first-aid needs of burn patients. In this study, polycaprolactone/chitosan (PCL/CS) was used as an electrospun nanofiber matrix, and curcumin (CUR), a molecule with excellent anti-inflammatory and antioxidant properties, was introduced to construct polycaprolactone/ chitosan graft copolymer-zein-curcumin electrospun nanofibers (PCL/CS-ZE-CUR). The results of clinical experiments suggest that compared with traditional dressings, based on the excellent mechanical properties and antibacterial activity of PCL/CS, the new dressing can exhibit oxygen free radical-scavenging abilities of CUR to accelerate wound healing and is expected to provide a beneficial upgrade for wound emergency care.
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Iacob, Andreea-Teodora, Maria Drăgan, Oana-Maria Ionescu, Lenuța Profire, Anton Ficai, Ecaterina Andronescu, Luminița Georgeta Confederat, and Dan Lupașcu. "An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management." Pharmaceutics 12, no. 10 (October 17, 2020): 983. http://dx.doi.org/10.3390/pharmaceutics12100983.
Анотація:
Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.
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Pásztor, Noémi, Emőke Rédai, Zoltán-István Szabó, and Emese Sipos. "Preparation and Characterization of Levofloxacin-Loaded Nanofibers as Potential Wound Dressings." Acta Medica Marisiensis 63, no. 2 (June 27, 2017): 66–69. http://dx.doi.org/10.1515/amma-2017-0014.
Анотація:
Abstract Objective: The study aimed at obtaining and characterizing levofloxacin-loaded, poly(ε-caprolactone) electrospun nanofiber formulations to be used as antibacterial wound dressings. Methods: Drug-loaded nanofibers were obtained by the electrospinning process and their morphology was determined using scanning electron microscopy. Structural analysis of the prepared nanofibers was carried out using differential scanning calorimetry and dissolution testing was performed in order to determine drug release. Results: Both nanofiberous formulations (containing 20 % and 50 % w/w levofloxacin) showed dimensions in the range of few hundred nanometers. Thermograms indicated that the formulation containing 20% levofloxacin was totally amorphized, showing a rapid release of the active, in 20 minutes. Conclusions: The poly(ε-caprolactone)-based electrospun nanofibers, containing levofloxacin presented suitable characteristics for obtaining potential antibacterial wound dressings.
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Gao, Chen, Liyuan Zhang, Juan Wang, Miao Jin, Qianqian Tang, Zhongrong Chen, Yue Cheng, Runhuai Yang, and Gang Zhao. "Electrospun nanofibers promote wound healing: theories, techniques, and perspectives." Journal of Materials Chemistry B 9, no. 14 (2021): 3106–30. http://dx.doi.org/10.1039/d1tb00067e.
Анотація:
We provides a review on how electrospun nanofiber scaffolds promote wound healing and how the technology has been used for fabricating multi-functional nanofiber scaffolds that have greatly promoted the development of wound healing dressings.
Дисертації з теми "Nanofiber wound dressings":
1
Santhanam, Ramya. "LOCALIZED WOUND HEALING: A MATHEMATICAL MODEL FOR ELECTROMAGNETIC INDUCTION ON COATED NANOFIBER WOUND DRESSINGS." Akron, OH : University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1147883471.
Анотація:
Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2006."May, 2006." Title from electronic thesis title page (viewed 12/03/2007) Advisor, S.I. Hariharan; Committee members, Daniel B. Sheffer, Narender P. Reddy; Department Chair, Daniel B. Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
2
Dzurická, Lucia. "Příprava a charakterizace krytů ran." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-414181.
Анотація:
The diploma thesis if focused on the study of bioactive hydrogél and nanofiber wound dressings composed of natural biopolymers, which were functionalized by active compounds in the form of analgesic, antibiotics and enzymes. Hydrogél wound dressings were constituted from alginate and chitosan and nanofibers were created from polyhydroxybutyrate. The following 7 active compounds were selected to be added to the wound dressings: ampicillin, streptomycin, ibuprofen, papain, bromelain, collagenase and trypsin. In the theoretical part the structure of the skin and types of wound injuries were described. This part also talks about types of wound dressing and their applications, as well as treatment of skin wounds using enzymes and compounds with analgesic and antimicrobial properties. In addition, this section describes safety assays, in particular cytotoxicity assays on human cells. At the beginning of the experimental part, the process of preparation of hydrogél wound dressing was optimised. Subsequently, the dressings were enriched with active compounds and the rate of gradual releasing of the substances into model environment was monitored. In the case of enzymes, their proteolytic activity was also tested after their incorporation to the wound dressings. Furthermore, the prepared bioactive wound dressings were analyzed for possible cytotoxic effect on human keratinocytes. Finally, the wound dressing with combined content of active substances was created and also characterized for the rate of substance release, proteolytic activity and cytotoxicity. Antimicrobial activity of this wound dressings, against two selected strains of microorganisms: Escherichia coli and Staphylococcus epidermidis, was also evaluated.
3
Nováková, Laura. "Nové možnosti v hojení ran." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449375.
Анотація:
The diploma thesis is focused on the study of fibrous wound dressings prepared by electrospinning method from natural biopolymers. Three active ingredients were added to the dressings: ampicillin, ibuprofen and collagenase, which are responsible for relieving pain, reducing the risk of infection and selectively removing necrotic tissue in the wound. The theoretical part describes the therapeutic dressings currently available on the market and the most common methods of nanofiber production. The experimental part evaluates the optimization of the preparation of gelatin, alginate and chitosan fibrous wound dressings, which were subsequently enriched with active substances and their gradual release into the model environment was determined spectrophotometrically. Antimicrobial effects against E.coli and S. epidermidis strains andantifungal activity against C. glabrata yeast were monitored. Finally, two cytotoxicity tests on the human keratinocyte cell line HaCaT confirmed the safety of the prepared products, which can serve as bioactive skin dressings in the future.
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Balášová, Patricie. "Příprava a charakterizace moderních krytů ran." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449701.
Анотація:
This diploma thesis is focused on the study of bioactive wound dressings. During the thesis, hydrogel, lyophilized and nanofiber wound dressings were prepared. Hydrogel and lyophilized wound dressings were prepared on basis of two polysaccharides – alginate and chitosan. Nanofiber wound dressings were prepared by spinning polyhydroxybutyrate. All prepared wound dressings were enriched with bioactive substances, which represented analgesics (ibuprofen), antibiotics (ampicillin) and enzymes (collagenase). Into hydrogel and lyophilized wound dressings were all the mentioned active substances incorporated, whereas nanofiber wound dressings were only with ibuprofen and ampicillin prepared. The theoretical part deals with the anatomy and function of human skin. There was explained the process of wound healing and also there were introduced available modern wound dressings. The next chapter of the theoretical part deals with materials for preparing wound dressings (alginate, chitosan, polyhydroxybutyrate) and with active substances, which were used during the experimental part of this thesis. In the theoretical part, the methods of preparation of nanofiber wound dressings and also the methods of cytotoxicity testing used in this work were presented. The first part of the experimental part of this thesis was focused on preparing already mentioned wound dressings. Then, their morphological changes over time and also the gradual release of incorporated active substances into the model environment were monitored. The gradual release of ampicillin was monitored not only spectrophotometrically, but also by ultra-high-performance chromatography. In wound dressings, in which collagenase was incorporated, was also the final proteolytic activity of this enzyme monitored. The effect of the active substances was observed on three selected microorganisms: Escherichia coli, Staphylococcus epidermidis and Candida glabrata. The cytotoxic effect of the active substances on the human keratinocyte cell line was monitored by MTT test and LDH test. A test for monitoring the rate of wound healing – a scratch test – was also performed.
5
Leung, Victor Ka Lun. "Engineering design of nanofibre wound dressings." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/51553.
Анотація:
This research aimed to develop a nanofibrous carrier design process for hydrophilic, small-molecule drugs for controlled wound healing. Kynurenine was used as representative example, as it presented challenges with its size and structure necessitating significant optimization to reach release target. The objective of the design is thus to facilitate controlled healing via addressing hypotheses on carrier material compatibility, release control through process or material modification, and fabrication of continuous structures.
The design process began with material selection, which identified poly(vinyl alcohol) (PVA) as the candidate carrier. Experimental verification via drug-polymer interaction characterization suggested that kynurenine formed a solution with PVA, and was encapsulated within PVA nanofibres, implying drug release is diffusion-controlled. The characterization process provided more insightful understanding of drug release mechanism compared to data fitting to empirical models performed in existing literatures.
Release assays showed complete kynurenine release from PVA within five hours. In subsequent optimization studies, three methods to control release from nanofibres were proposed. First, material parameters such as molecular weight, electrospinning concentration and drug dosage were shown to be a suitable fine-control mechanism. The second method was matrix modification via heat treatment, which changed the burst release behavior, although drug entrapment was observed. The third method was a composite approach in which the drug-polymer system was encased in the more hydrophobic poly(lactic-co-glycolic acid) (PLGA), which significantly reduced burst release, and extended the release period to over 120 hours.
Applicability of the PVA kynurenine carrier, planar dressings and braided sutures were explored, which could become useful for a variety of wounds. For planar dressings, the proposed design showed tensile properties within the range of various commercial dressing products and thus was considered robust for handling and application to open acute and chronic wounds. For sutures, process modification in 3D braiding was introduced to significantly increase tensile strength, which could help create robust wound closure devices for patients prone to scarring.
The outcomes of this study demonstrated customization of drug release and structural properties of wound dressing materials to suit various open wounds, to provide a platform for supporting the expanding therapeutic functionalities in next generation wound dressings.Applied Science, Faculty of
Materials Engineering, Department of
Graduate
6
Uppal, Rohit. "A novel equation to assess degree of crystallinity of filament yarns and hyaluronic acid nanofiber wound dressing and electrospinning of cellulose nanofibers /." Search for this dissertation online, 2005. http://wwwlib.umi.com/cr/ksu/main.
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Smith-Freshwater, Alicia P. "PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/19.
Анотація:
A novel dendritic wound dressing was designed and characterized for its potential to treat chronic wounds. Comprised of gelatin, dendrimer, synthetic polymer and antibiotics, the dressing was electrospun to mimic the natural extracellular matrix (ECM). Gelatin is biocompatible, biodegradable, non-toxic, and easily available. The antibiotic, doxycycline, has the ability to inhibit matrix metalloproteinases. Matrix metalloproteinases, which occur in excess in chronic wounds, degrade the reconstituted ECM. Starburst™ polyamidoamine (PAMAM) dendrimer G3.5, which provides a versatile and structurally controlled architecture to construct nanomedicine, was covalently bonded to the gelatin backbone and electrospun into nanofibers with gelatin, doxycycline and stabilizing polymers. The proposed gelatin/dendrimer hybrid provides a bacterial free environment and mimics the ECM to promote wound healing. The development of this new polymeric matrix is an important step in advancing the use of bioactive nanofibers with targeted and controlled drug delivery as a wound dressing.
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Aduba, Donald C. Jr. "Multi-platform arabinoxylan scaffolds as potential wound dressing materials." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3955.
Анотація:
Biopolymers are becoming more attractive as advanced wound dressings because of their naturally derived origin, abundance, low cost and high compatibility with the wound environment. Arabinoxylan (AX) is a class of polysaccharide polymers derived from cereal grains that are primarily used in food products and cosmetic additives. Its application as a wound dressing material has yet to be realized. In this two-pronged project, arabinoxylan ferulate (AXF) was fabricated into electrospun fibers and gel foams to be evaluated as platforms for wound dressing materials. In the first study, AXF was electrospun with varying amounts of gelatin. In the second study, AXF was dissolved in water, enzymatically crosslinked and lyophilized to form gel foams. The morphology, mechanical properties, porosity, drug release kinetics, fibroblast cell response and anti-microbial properties were examined for both platforms. Carbohydrate assay was conducted to validate the presence of arabinoxylan ferulate in the electrospun GEL-AXF fibers. Swelling and endotoxin quantification studies were done to evaluate the absorptive capacity and sterilization agent efficacy respectively in AXF foams. The results indicated successful fabrication of both platforms which validated the porous, absorptive, biocompatibility and drug release properties. The results also exhibited that silver impregnated AXF scaffolds inhibited growth of Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis bacteria species, anti-microbial properties necessary to function as advanced wound dressing materials. Future work will be done to improve the stability of both platforms as well as evaluate its applications in vivo.
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Johansson, Carne Lisa. "Evaluation of electrospun lignin/polyvinyl alcohol/cellulose nanofiber mats." Thesis, Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-85167.
Анотація:
Polymeric electrospun nanofiber mats have recently emerged as a promising alternative to conventional wound dressings for non-healing wounds. Its large surface area, porosity and scalability are only a few of the promising characteristics of electrospun nanofibers. Nanocellulose, separated from biomass, have also proven a suitable reinforcement to these electrospun nanofibers, giving them stability and strength. Lignin has shown to possess antimicrobial and antioxidant activity, that could aid the healing process. In this project, kraft lignin, polyvinyl alcohol (PVA) and (2,2,6,6-tetramethylpiperidine-1-oxyl radical)-mediated oxidised cellulose nanofibers (CNF) has been electrospun into nanofiber mats and their applicability as a wound dressing was investigated. The electrospinning process was evaluated at different ratios of PVA/lignin: CNF, and the obtained nanofiber mats were crosslinked to restrict water solubility. Physical crosslinking was made through a heat treatment and a freeze thawing process. Mechanical properties, swelling capacity and oxygen permeability were evaluated and analysed based on the CNF content of the electrospun solutions, as well as the crosslinking methods used. Results show that the electrospun nanofiber mats where stable in water after a heat treatment at 150 °C and 3 freeze-thawing cycles. These crosslinking methods did not affect the morphology or size of the fibers. However, tensile strength and elastic modulus was improved with it. The addition of 0.1 wt% CNF into the electrospinning solution improved oxygen permeability, mechanical properties, and swelling capacity, which can be attributed to a small fiber diameter and increased crystallinity. However, exceeding that level of CNF deteriorated the same properties because of uneven fibers with beading. This material is showing promising characteristics of a wound dressing, with high oxygen permeability and swelling capacity owing to thin nanofibers and a porous network.
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Heunis, Tiaan de Jager. "Development of an antimicrobial wound dressing by co-electrospinning bacteriocins of lactic acid bacteria into polymeric nanofibers." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71616.
Анотація:
Thesis (PhD)--Stellenbosch University, 2012.ENGLISH ABSTRACT: Skin is the largest organ in the human body and serves as a barrier that protects the underlying tissue of the host from infection. Injury, however, destroys this protective barrier and provides a perfect opportunity for microorganisms to invade the host and cause infection, thereby affecting the normal wound healing processes. Furthermore, the ability of microbial pathogens to rapidly develop resistance towards a variety of antimicrobial compounds hampers the effective treatment and control of infections. Antimicrobial-resistant pathogens are increasingly being isolated from patients, placing a huge burden on the health care sector. The search for new and novel antimicrobial agents and treatments is thus of utmost importance and will continue to play an integral role in medical research. Antimicrobial peptides (AMPs) may serve as possible alternatives to antibiotics, or may be used in combination with antibiotics to reduce the risk of antimicrobial resistance. AMPs play a role in innate defence and are produced by a variety of mammals, plants, reptiles, amphibians, birds, fish and insects. The AMPs of bacteria (bacteriocins), especially those of lactic acid bacteria (LAB), are receiving increased attention as antimicrobial agents to treat bacterial infections. Electrospun nanofibers have characteristics that make them suitable as wound dressings, i.e. high oxygen permeability, variable pore size, high surface area to volume ratio and nanofibers are morphologically similar to the extracellular matrix. The ability to incorporate of a variety of biologically active compounds into nanofibers increases their potential as wound dressings. A novel approach would be to incorporate bacteriocins from LAB into nanofiber scaffolds to generate antimicrobial wound dressings. In this study, the feasibility of co-electrospinning bacteriocins from LAB into nanofibers was investigated. Plantaricin 423, produced by Lactobacillus plantarum 423, was successfully co-electrospun into poly(ethylene oxide) (PEO) nanofibers. Plantaricin 423 retained activity after the electrospinning process and continued to inhibit the growth of Lactobacillus sakei DSM 20017T and Enterococcus faecium HKLHS. Viable cells of L. plantarum 423 were also successfully co-electrospun into PEO nanofibers, albeit with a slight reduction in viability. A nanofiber drug delivery system was developed for plantaricin 423 and bacteriocin ST4SA, produced by Enterococcus mundtii ST4SA, by blending PEO and poly(D,L-lactide) (PDLLA) in a suitable solvent before electrospinning. Nanofibers were produced that released the bacteriocins over an extended time period. The PEO:PDLLA (50:50) nanofiber scaffold retained its structure the best upon incubation at 37 °C and released active plantaricin 423 and bacteriocin ST4SA. Nisin A was also successfully co-electrospun into a PEO:PDLLA (50:50) nanofiber scaffold and nisin A, released from the nanofibers, inhibited the growth of Staphylococcus aureus in vitro. Nisin A-containing nanofiber scaffolds significantly reduced viable S. aureus cells in infected skin wounds and promoted wound healing in non-infected wounds. As far as we could determine we are the first to show that bacteriocin-eluting nanofiber scaffolds can be used to treat skin infections and influence wound healing.
AFRIKAANSE OPSOMMING: Vel is die grootse orgaan in die menslike liggaam en dien as buitelaag wat die gasheer se onderliggende weefsel teen infeksie beskerm. Beskadigde vel verloor egter hierdie beskermende eienskap en gee mikroörganismes die geleentheid om die liggaam binne te dring, infeksie te veroorsaak en die normale prosesse geassosieer met wondgenesing te beïnvloed. Die suksesvolle behandeling en beheer van infeksies word gedemp deur die vermoë van mikroörganismes om vinnig weerstand teen antimikrobiese middels te ontwikkel. Mikroörganismes met antimikrobiese weerstand word geredelik van pasiënte geïsoleer en dit plaas enorme druk op die gesondheidssektor. Die soeke na nuwe antimikrobiese middels en behandelings is dus van uiterste belang en sal altyd ‘n integrale rol in geneeskunde navorsing speel. Antimikrobiese peptiede (AMPe) kan moontlik as alternatief tot antibiotika dien, of kan in kombinasie daarmee gebruik word om die ontwikkeling van antimikrobiese- weerstandbiedenheid te verhoed. AMPe speel ‘n rol in ingebore beskerming en word deur soogdiere, plante, reptiele, voëls, visse en insekte geproduseer. AMPe van bakterieë (bakteriosiene), veral die van melksuurbakterieë (MSB), wek toenemende belangstelling as antimikrobiese middels vir die behandeling van bakteriële infeksies. Nanovesels, wat deur middel van ‘n elektrospin proses geproduseer word, het eienskappe wat hul aanloklik maak as wondbedekking, naamlik hoë suurstof deurlaatbaarheid, verskeie porie grottes, ‘n hoë oppervlakte tot volume verhouding, sowel as ‘n morfologiese struktuur wat die ekstrasellulêre matriks naboots. Die vermoë om ‘n verskeidenheid biologies aktiewe komponente in nanovesels te inkorporeer verhoog hul potensiaal as wondbedekkingsmateriaal. ‘n Unieke benadering is die inkorporasie van bakteriosiene van MSB in nanovesels om ‘n antimikrobiese wondbedekking te ontwikkel. In hierdie studie is die vermoë om bakteriosiene van MSB in nanovesels te inkorporeer, deur middel van ‘n mede-elektrospin proses, ondersoek. Plantarisien 423, geproduseer deur Lactobacillus plantarum 423, was suksesvol deur die mede-elektrospin proses in poliëtileen oksied (PEO) nanovesels geinkorporeer. Plantarisien 423 het na die elektrospin proses steeds sy antimikrobiese aktiwiteit behou en het die groei van Lactobacillus sakei DSM 20017T en Enterococcus faecium HKLHS geïnhibeer. Lewende selle van L. plantarum 423 was ook suksesvol deur die mede-elektrospin proses in PEO nanovesels geinkorporeer, alhoewel die lewensvatbaarheid van die selle effens afgeneem het. ‘n Nanovesel matriks is ontwikkel om die vrystelling van plantarisien 423 en bakteriosien ST4SA, geproduseer deur Enterococcus mundtii ST4SA, te beheer deur PEO en poli(D,L-melksuur) (PDLMS) in ‘n geskikte oplosmiddel te vermeng voor die elektrospin proses. Nanovesels is geproduseer wat die bakteriosiene oor ‘n verlengde tydperk kon vrystel. ‘n PEO:PDLMS (50:50) nanovesel matriks het sy stuktuur die beste behou tydens inkubasie by 37 °C en het aktiewe plantarisien 423 en bakteriosien ST4SA vrygestel. Nisien A was met dieselfde tegniek in PEO:PDLMS (50:50) geinkorporeer en nisien A, wat deur die nanovesels vrygestel was, het die groei van Staphylococcus aureus in vitro geïnhibeer. Die nisien A-bevattende nanovesel matriks het die aantal lewende selle van S. aureus noemenswaardig verminder in geïnfekteerde wonde en kon die genesing van wonde, wat nie geïnfekteer was, stimuleer. Sover ons kon vastel is hierdie die eerste gepubliseerde navorsing wat toon dat bakteriosiene, geinkorporeer in nanovesels, gebruik kan word om vel infeksies te beheer en wondgenesing te stimuleer.
Частини книг з теми "Nanofiber wound dressings":
1
Gokarneshan, N., D. Anitha Rachel, V. Rajendran, B. Lavanya, and Arundhathi Ghoshal. "Wound Dressings from Nanofiber Matrix of Calcium Alginate/PVA Blend." In Emerging Research Trends in Medical Textiles, 1–7. Singapore: Springer Singapore, 2015. http://dx.doi.org/10.1007/978-981-287-508-2_1.
2
Liu, Xin, Tong Lin, J. Fang, Gang Yao, and X. G. Wang. "Electrospun Nanofibre Membranes as Wound Dressing Materials." In Advances in Science and Technology, 125–30. Stafa: Trans Tech Publications Ltd., 2008. http://dx.doi.org/10.4028/3-908158-14-1.125.
3
Ghasemi, Mina Vaez, and Jhamak Nourmohammadi. "Fabrication of NO-Releasing Silk Fibroin Nanofiber for Wound Dressing Application." In Eco-friendly and Smart Polymer Systems, 75–78. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45085-4_19.
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Růžičková, Jana, Vladimír Velebný, Jindřich Novák, Katarzyna Szuszkiewicz, Kateřina Knotková, Marcela Foglarová, and Marek Pokorný. "Hyaluronic Acid Based Nanofibers for Wound Dressing and Drug Delivery Carriers." In Intracellular Delivery II, 417–33. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8896-0_20.
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Nisar, Safiya, Sonal Chauhan, and Sunita Rattan. "Ciprofloxacin Loaded Chitosan/Alginate/PEO Nanofibers for Their Application in Antimicrobial Wound Dressing." In Springer Proceedings in Physics, 35–42. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8625-5_4.
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Manoukian, O. S., A. Ahmad, C. Marin, R. James, A. D. Mazzocca, and S. G. Kumbar. "Bioactive nanofiber dressings for wound healing." In Wound Healing Biomaterials, 451–81. Elsevier, 2016. http://dx.doi.org/10.1016/b978-1-78242-456-7.00022-2.
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Gionfriddo, William, and Lakshmi Nair. "Drug Loaded Nanofiber Matrices as Diabetic Wound Dressings." In Nanotechnology and Nanomedicine in Diabetes, 325–44. Science Publishers, 2012. http://dx.doi.org/10.1201/b11775-22.
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Vega-Cázarez, Claudia A., Dalia I. Sánchez-Machado, and Jaime López-Cervantes. "Overview of Electrospinned Chitosan Nanofiber Composites for Wound Dressings." In Chitin-Chitosan - Myriad Functionalities in Science and Technology. InTech, 2018. http://dx.doi.org/10.5772/intechopen.76037.
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Jee Kanu, Nand, Eva Gupta, Venkateshwara Sutar, Gyanendra Kumar Singh, and Umesh Kumar Vates. "An Insight into Biofunctional Curcumin/Gelatin Nanofibers." In Nanofibers - Synthesis, Properties and Applications. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97113.
Анотація:
Electrospinning (ESPNG) was used to synthesize ultrathin (UT) and uniform nanofibers (from 5 nm to a few hundred nanometers) of various materials which have biomedical applications (BAs) such as dressing of wounds, drug discharge, and so on and so forth. In the first half of the report, there is an audit on the nanofibers having low diameter so that it could have larger surface area to volume proportion, likewise with that it would have sufficient porosity and improved mechanical properties required for wound healing. Nanofibrous mats (NMs) with high biocompatibility could be utilized during healing of wounds by sustained release of curcumin (Cc) and oxygen. The ESPNG was understood through in-depth numerical investigation in the present report. Furthermore, the process parameters (PMs) were reviewed in depth for their contributions in synthesizing UT - Curcumin/Gelatin (Cc/G) nanofibers (NFs) of optimum diameter. The aim of the discussion was to demonstrate that simply optimizing biofunctional (BF) - Cc/G NFs might not be enough to satisfy experts until they are also given access details about the complete ESPNG method (mathematical mechanism) to improve hold over the synthesis of NMs (suitable for BAs) for the release profile of Cc throughout critical periods of healing process.
Тези доповідей конференцій з теми "Nanofiber wound dressings":
1
Su, Sena, Mehmet Eroglu, Cevriye Kalkandelen, Nazmi Ekren, Faik Nuzhet Oktar, Mahir Mahirogullari, and Oguzhan Gunduz. "Core-shell structured hyaluronic acid and keratin nanofibers for wound dressing." In 2019 Medical Technologies Congress (TIPTEKNO). IEEE, 2019. http://dx.doi.org/10.1109/tiptekno.2019.8895083.
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Bhattacharjee, Abhishek, Claudia Gentry-Weeks, Richard Clark, and Yan Vivian Li. "Study of Bacterial Components Activating a Colorimetric Transition in Bacteria-Detecting Nanofiber Wound Dressing Applications." In Pivoting for the Pandemic. Iowa State University Digital Press, 2020. http://dx.doi.org/10.31274/itaa.12123.