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1

McKee, David. "Nuclear Transparency and Single Particle Spectral Functions from Quasielastic A(e,e'p) Reactions up to Q2=8.1 GeV2." Washington, D.C : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Energy Research ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2003. http://www.osti.gov/servlets/purl/824828-CBQre3/native/.

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Thesis (Ph.D.); Submitted to New Mexico State Univ., Las Cruces, NM (US); 1 May 2003.<br>Published through the Information Bridge: DOE Scientific and Technical Information. "JLAB-PHY-03-22" "DOE/ER/40150-2731" David McKee. 05/01/2003. Report is also available in paper and microfiche from NTIS.
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2

Carnahan, Brian. "Strangeness Photoproduction in the {gamma}p {yields} K{sup 0} {Sigma}{sup +} Reaction." Washington, D.C : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Energy Research ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2003. http://www.osti.gov/servlets/purl/824935-CL5ICZ/native/.

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Анотація:
Thesis (Ph.D.); Submitted to the Catholic Univ. of America, Washington, DC (US); 1 May 2003.<br>Published through the Information Bridge: DOE Scientific and Technical Information. "JLAB-PHY-03-40" "DOE/ER/40150-2764" Brian Carnahan. 05/01/2003. Report is also available in paper and microfiche from NTIS.
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3

Terral, Guillaume. "Apports de l'échange hydrogène/deutérium couplé à la spectrométrie de masse en protéomique structurale pour la caractérisation de complexes multi-protéiques." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF019/document.

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Анотація:
Ce travail de thèse porte sur développement de méthodes en spectrométrie de masse structurale pour l’analyse de protéines recombinantes et de leurs complexes associés. L’objectif central s’est porté sur des développements méthodologiques en échange hydrogène/deutérium couplé à la spectrométrie de masse (HDX-MS). Les techniques biophysiques de caractérisation structurale à haute résolution comme la cristallographie ou la RMN se heurtent régulièrement à des problèmes de productions de cristaux, de taille de complexes analysables ou encore de quantité de matériel nécessaire importante. Le dévelop
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4

Kamara, Konakpo Parfait. "Stratégies d’utilisation du bio hydrogène pour la technologie PEMFC : utilisation directe." Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALI037.

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Анотація:
La France dans le but de décarboner son mix énergétique et baisser ses émissions de CO2 a décidé d’investir massivement dans la production décarbonée d’hydrogène comme vecteur d’énergie pour des applications de mobilités ou stationnaires[1]. Sur le million de tonnes d’hydrogène produit en France, 96 % est produit par vaporeformage d’hydrocarbures. La stratégie Française vise à développer la filière hydrogène en investissant dans l’installation d’électrolyseurs. De plus les dernières découvertes d’énormes gisements d’hydrogène naturel (46 millions de tonnes d’hydrogène en Lorraine) crée l’entho
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5

Bourguet, Maxime. "Développements méthodologiques en spectrométrie de masse structurale pour la caractérisation de complexes biologiques multiprotéiques." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAF013.

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Анотація:
Ce travail de thèse porte sur le développement de méthodes de spectrométrie de masse (MS) structurale pour la caractérisation de systèmes protéiques complexes, souvent réfractaires aux approches biophysiques classiques. Dans ce contexte, les développements entrepris furent notamment focalisés sur la caractérisation de complexes impliqués dans la biogénèse des ribosomes et dans la régulation transcriptionnelle, fonctions cellulaires essentielles pouvant être liées à de nombreuses pathologies humaines dont certains cancers. Ainsi, les approches par MS native, pontage chimique et d’HDX-MS ont per
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6

Castel, Jérôme. "Developpements en spectrométrie de masse structurale pour la caratérisation de protéines d'intérêt thérapeutique." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF003.

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Анотація:
Ce travail de thèse porte sur des développements méthodologiques en spectrométrie de masse (MS) structurale, principalement par échange hydrogène/deutérium couplé à la MS (HDX-MS), en MS native couplée ou non à la mobilité ionique (IM-MS) et plus récemment en photométrie de masse, pour la caractérisation de différentes protéines d’intérêt thérapeutique. Ce travail a notamment permis de montrer l’apport d’une combinaison d’approches en MS structurale pour la caractérisation approfondie des protéines membranaires, de l’analyse des protéines entières jusqu’à leur dynamique conformationnelle. La m
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7

Bleijlevens, Boris. "Activation and sensing of hydrogen in nature." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/61349.

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8

Dua, Rupak. "Enhanced Anchorage of Tissue-Engineered Cartilage Using an Osteoinductive Approach." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/context/etd/article/2559/type/native/viewcontent.

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Анотація:
Articular cartilage injuries occur frequently in the knee joint. Several methods have been implemented clinically, to treat osteochondral defects but none have been able to produce a long term, durable solution. Photopolymerizable cartilage tissue engineering approaches appear promising; however, fundamentally, forming a stable interface between the tissue engineered cartilage and native tissue, mainly subchondral bone and native cartilage, remains a major challenge. The overall objective of this research is to find a solution for the current problem of dislodgment of tissue engineered cartila
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9

Fernandes, Wren Austin. "Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/59502/1/Wren_Fernandes_Thesis.pdf.

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Hydrogels are hydrophilic, three dimensional polymers that imbibe large quantities of water while remaining insoluble in aqueous solutions due to chemical or physical cross-linking. The polymers swell in water or biological fluids, immobilizing the bioactive agent, leading to drug release in a well-defined specific manner. Thus the hydrogels’ elastic properties, swellability and biocompatibility make them excellent formulations for drug delivery. Currently, many drug potencies and therapeutic effects are limited or otherwise reduced because of the partial degradation that occurs before the adm
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10

Ranz, Matthieu. "Échange hydrogène-deutérium couplé à la spectrométrie de masse native des acides nucléiques." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0315.

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Анотація:
Les oligonucléotides d’ADN riches en guanines peuvent former des structures secondaires non-canoniques appelées G-quadruplexes (G4). Ces structures sont constituées d’empilements de G-tétrades, des assemblages composés de 4 guanines liées entre elles par un réseau de 8 liaisons hydrogène et stabilisées par des interactions avec un cation métallique (généralement K+ ou Na+). Les G4s sont impliqués dans la régulation de plusieurs processus biologiques, particulièrement au sein des télomères et des promoteurs d’oncogène, et sont considérés comme des cibles thérapeutiques ayant une structure très
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11

Yip, D. C. F. "Nature and control of water in synthetic hydrogels." Thesis, University of Salford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381735.

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12

Dumonteil, Claire. "Interaction hydrogène - catalyseurs d'hydrotraitement : nature des espèces adsorbées et réactivité." Lyon 1, 1997. http://www.theses.fr/1997LYO10375.

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Анотація:
L'interaction hydrogene - sulfure est un processus complexe qui conduit a la formation de lacunes anioniques et de groupements s-h, dont la presence est necessaire pour conferer des proprietes catalytiques. L'objectif de ce travail etait de determiner la nature de l'interaction entre l'hydrogene et ces solides en couplant des caracterisations physico-chimiques a des mesures de proprietes catalytiques. Ce travail a ete realise sur le sulfure de ruthenium depose sur zeolithe ky, afin de completer des etudes anterieures et sur mos#2 non supporte, supporte sur alumine et promu par du ni. La phase
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13

Henry, Dilys M. "The nature and effects of hydrogen in weldalite aerospace alloy and other commercial aluminium-lithium alloys." Thesis, Brunel University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340935.

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14

Sayet, Julien. "Effect of grain boundary nature and connectivity on the diffusion of hydrogen in heterogeneous materials : numerical study." Electronic Thesis or Diss., La Rochelle, 2023. http://www.theses.fr/2023LAROS005.

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Анотація:
Pour anticiper la fragilisation par l'hydrogène, il faut connaître l'effet des différentes échelles temporelles et spatiales sur les processus de diffusion et de piégeage dans la microstructure du matériau. Dans ce travail, nous examinons l'impact de différents types de jonctions triples (TJ) et de joints de grains (GB) et de leur connectivité sur la diffusion de l'hydrogène. Tout d'abord, nous proposons quatre algorithmes pour contrôler la distribution des fractions de TJ en fonction d'une fraction donnée de joints de grains aléatoires. Ensuite, à l'aide de la modélisation par éléments finis,
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15

Rice, Mark Andrew. "PEG-based hydrogels as chondrocyte carriers for tissue engineered cartilage: Controlling extracellular matrix evolution and integration with native cartilage." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3207731.

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16

Dey, Abhishek. "Nature of iron-sulfur bonds in electron transfer and catalytic actives sites : contribution to reactivity and the role of hydrogen bonding /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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17

Ferreira, Alexandre José Domingues. "Polímeros de hidrogéis com água de reúso e de abastecimento no desenvolvimento de mudas de espécies arbóreas da floresta estacional semidecidual." Universidade Federal de São Carlos, 2014. https://repositorio.ufscar.br/handle/ufscar/31.

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Анотація:
Made available in DSpace on 2016-06-02T18:55:28Z (GMT). No. of bitstreams: 1 6339.pdf: 1320900 bytes, checksum: ceafdc5598f1fbb6c687c57d58657bc1 (MD5) Previous issue date: 2014-08-07<br>Universidade Federal de Sao Carlos<br>The seasonal semideciduous forests from southeastern Brazil have high plant species richness, but have been strongly affected by human interferences, which let them very degraded: nowadays they are represented by small isolated fragments, immersed in a landscape dominated by agriculture and large urban centers. In this sense, the ecology of restoration arises in order to
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18

Sánchez, Ferrero Aitor. "Biomimetic hydrogels for in situ bone tissue engineering : nature-inspired crosslinking methods as a tool to tune scaffold physical properties." Doctoral thesis, Universitat Politècnica de Catalunya, 2015. http://hdl.handle.net/10803/373909.

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Анотація:
The global incidence of bone fractures, and subsequently that of non-healing ones, is expected to rise in the coming decades, mostly due to an increased risk of age-related conditions. Currently, the biomaterials field is moving towards the design of scaffolds mimicking the cell microenvironment to guide stem cells differentiation and recapitulate the development of target tissues. Biomimicry is a wide concept and several approaches have been adopted to produce cellinstructive scaffolds. Herein, we have explored the use of citric acid and lysyl oxidase, both of them related to bone nanostructu
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19

Costa, Fernanda Janaína Oliveira Gomes da. "Emprego de técnicas e termoanalíticas na análise de amidos nativos e modificados de mandioca." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2010. http://tede2.uepg.br/jspui/handle/prefix/689.

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Анотація:
Made available in DSpace on 2017-07-21T18:53:16Z (GMT). No. of bitstreams: 1 Fernanda Janaina Oliveira Gomes da Costa.pdf: 2530982 bytes, checksum: 65f2e845c0bdca1384a01a29d20c0298 (MD5) Previous issue date: 2010-02-08<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Starch is an abundant carbohydrate in nature, can be extracted from several botanical sources and has many industrial applications, mainly in the food sector.Due to some limitations of native starch, the production of modified starch has been an alternative to overcome these restrictions and promote increase in
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20

VENUTA, MARIA LUISA. "La città da energivora a nodo attivo delle reti di produzione e di scambio energetico." Doctoral thesis, Università Cattolica del Sacro Cuore, 2007. http://hdl.handle.net/10280/85.

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Анотація:
Il concetto di rete dell'informazione può diventare uno schema logico con cui descrivere l'evoluzione delle politiche sulle energie rinnovabili e sulla sostenibilità? La ricerca è stata svolta analizzando l'architettura delle due reti (internet e reti energetiche) e l'evoluzione del bene prodotto e distribuito nella rete energetica, l'energia, esplicitando l'accessibilità da parte della distribuzione mondiale delle risorse petrolifere tradizionali e delle risorse rinnovabili. La struttura metodologica del progetto di ricerca si basa due tipi di analisi teorica: 1) l'analisi della nascita delle
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21

VENUTA, MARIA LUISA. "La città da energivora a nodo attivo delle reti di produzione e di scambio energetico." Doctoral thesis, Università Cattolica del Sacro Cuore, 2007. http://hdl.handle.net/10280/85.

Повний текст джерела
Анотація:
Il concetto di rete dell'informazione può diventare uno schema logico con cui descrivere l'evoluzione delle politiche sulle energie rinnovabili e sulla sostenibilità? La ricerca è stata svolta analizzando l'architettura delle due reti (internet e reti energetiche) e l'evoluzione del bene prodotto e distribuito nella rete energetica, l'energia, esplicitando l'accessibilità da parte della distribuzione mondiale delle risorse petrolifere tradizionali e delle risorse rinnovabili. La struttura metodologica del progetto di ricerca si basa due tipi di analisi teorica: 1) l'analisi della nascita delle
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22

VALINSKY, WILLIAM COREY. "ELECTROPHYSIOLOGICAL COMPARISON OF NaV1.5 EXPRESSED IN HEK293 CELLS TO NATIVE NaV CURRENTS IN CARDIAC MYOCYTES." Thesis, 2011. http://hdl.handle.net/1974/6658.

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Анотація:
Contraction of cardiac muscle is a highly regulated event that relies on a delicate balance of ions entering and leaving the cell through ion channels. In particular, voltage gated sodium channels are responsible for the rapid depolarization that leads to a contraction. During an oxidative challenge, sodium channels rapidly activate, but do not fully turn off. This alters the rate of cardiac repolarization and can induce cardiac arrhythmias. It is currently unknown whether the most common sodium channel isoform found in the heart, NaV1.5, generates this oxidant-induced persistent current or if
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23

Manikandan, K. "Crystal Structures Of Native And Xylosaccharides-Bound Alkali Thermostable Xylanase From An Alkalophilic Bacillus SP. NG-27: Structural Insights Into Alkalophilicity. Analysis Of C-H...O Hydrogen Bonds In Helices Of Globular Proteins." Thesis, 2006. https://etd.iisc.ac.in/handle/2005/328.

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Анотація:
Xylanases are xylan-degrading enzymes, belong to glycosyl hydrolases (GH). Xylanases from the two major families 10 (GH10) and 11 (GH11) catalyze the hydrolysis of internal β-, bonds of xylan backbone. Xylan is the second most abundant polysaccharide in nature. Nearly one third of the dry weight of the higher plants is xylan and therefore, xylanases have an important role in biomass conversions. Currently, the most effective application of xylanases is in prebleaching of kraft pulp to minimize the use of environmentally hazardous chemicals in the subsequent treatment stages. In recent years, t
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24

Manikandan, K. "Crystal Structures Of Native And Xylosaccharides-Bound Alkali Thermostable Xylanase From An Alkalophilic Bacillus SP. NG-27: Structural Insights Into Alkalophilicity. Analysis Of C-H...O Hydrogen Bonds In Helices Of Globular Proteins." Thesis, 2006. http://hdl.handle.net/2005/328.

Повний текст джерела
Анотація:
Xylanases are xylan-degrading enzymes, belong to glycosyl hydrolases (GH). Xylanases from the two major families 10 (GH10) and 11 (GH11) catalyze the hydrolysis of internal β-, bonds of xylan backbone. Xylan is the second most abundant polysaccharide in nature. Nearly one third of the dry weight of the higher plants is xylan and therefore, xylanases have an important role in biomass conversions. Currently, the most effective application of xylanases is in prebleaching of kraft pulp to minimize the use of environmentally hazardous chemicals in the subsequent treatment stages. In recent years, t
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25

Tsai, Hsin-Tung, and 蔡欣桐. "Application of polymer material by mimicking nature hydrogen bonding." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/93675748374074925722.

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碩士<br>國立中山大學<br>材料與光電科學學系研究所<br>98<br>This research includes two topics. The first topic is prepared a series of poly(methyl methacrylate) (PMMA)-based copolymers through free radical copolymerizations of methyl methacrylate in the presence of the either 2 - vinyl - 4,6 -diamino - 1, 3, 5triazine(VDAT) or vinylbenzyl -thymine (VBT). Using 1H nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), we investigated the thermal properties and hydrogen-bonding interactions within blends of the two copolymers poly(2-viny
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26

DePoy, Darren Lee. "The nature of luminous IRAS galaxies." Thesis, 1987. http://hdl.handle.net/10125/9343.

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27

Suri, Shalu. "Photopolymerizable scaffolds of native extracellular matrix components for tissue engineering applications." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-05-728.

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Анотація:
In recent years, significant success has been made in the field of regenerative medicine. Tissue engineering scaffolds have been developed to repair and replace different types of tissues. The overall goal of the current work was to develop scaffolds of native extracellular matrix components for soft tissue regeneration, more specifically, neural tissue engineering. To date, much research has been focused on developing a nerve guidance scaffold for its ability to fill and heal the gap between the damaged nerve ends. Such scaffolds are marked by several intrinsic properties including: (1) a bio
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28

Anh, Ha Thi Phuong, and 范安蒂. "Intelligent nature-derived coordinative hydrogel incorporated with HRP as dressing for infected wounds." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/5364qv.

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Анотація:
碩士<br>國立中央大學<br>生醫科學與工程學系<br>106<br>Metallogels were established based on coordinative interactions, exhibiting unique abilities, and being applied for various biomedical applications. However, the applications of metallogels for wound healing property has not been explored. In this study, we report a newly nature-derived metallogels developed by coordination of polyphenols and metal ions. Gelation occurs by mixing low-cost polyphenolic tannic acid (TA) and group (IV) metal ions (titanium ions) to form TA-TiIV gel. The TA-TiIV gel exhibits a good ability to incorporate diverse functional meta
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29

Pavan, S. "Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis." Thesis, 2015. https://etd.iisc.ac.in/handle/2005/3868.

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Анотація:
The thesis entitled “Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis" consists of five chapters. A basic introductory section describes the topics relevant to the work and the methods and techniques utilized. The main focus of the present work is to characterize the interaction patterns devoid of strong classical hydrogen bonds. The case studies include halogen bonds and hydrogen bonds involving bromine (as a halogen bond donor and hydrogen bond acceptor), intermolecular chalcogen bond formation involving sulphur, type I Br Br contacts, ty
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30

Pavan, S. "Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis." Thesis, 2015. http://etd.iisc.ernet.in/2005/3868.

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Анотація:
The thesis entitled “Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis" consists of five chapters. A basic introductory section describes the topics relevant to the work and the methods and techniques utilized. The main focus of the present work is to characterize the interaction patterns devoid of strong classical hydrogen bonds. The case studies include halogen bonds and hydrogen bonds involving bromine (as a halogen bond donor and hydrogen bond acceptor), intermolecular chalcogen bond formation involving sulphur, type I Br Br contacts, ty
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31

Chowdhury, Brojokishore. "Nature Of Solute-Solvent Interaction : Effect Of Solvent Polarity On Excited State Structure Of 2,2,2-Trifluroacetophenone And Effect Of Hydrogen Bonding In Hydrated Electron Absorption Spectrum." Thesis, 2006. https://etd.iisc.ac.in/handle/2005/602.

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Анотація:
In solution, the environment around the solute is determined solely by the solvent molecules, which are present closer to the solute. This interaction between solute and solvent shell is very crucial for equilibrium structure and reactivity of the solute. In the thesis, first we have investigated control of solvent polarity on the excited structure of 2,2,2 trifluroacetophenone and later effect of electronic excitation on the solvent shell organization has been described. It has been reported in literature that the lowest energy triplet configuration of 2,2,2 trifluroacetophenone corresponds
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32

Chowdhury, Brojokishore. "Nature Of Solute-Solvent Interaction : Effect Of Solvent Polarity On Excited State Structure Of 2,2,2-Trifluroacetophenone And Effect Of Hydrogen Bonding In Hydrated Electron Absorption Spectrum." Thesis, 2006. http://hdl.handle.net/2005/602.

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Анотація:
In solution, the environment around the solute is determined solely by the solvent molecules, which are present closer to the solute. This interaction between solute and solvent shell is very crucial for equilibrium structure and reactivity of the solute. In the thesis, first we have investigated control of solvent polarity on the excited structure of 2,2,2 trifluroacetophenone and later effect of electronic excitation on the solvent shell organization has been described. It has been reported in literature that the lowest energy triplet configuration of 2,2,2 trifluroacetophenone corresponds
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33

Gupta, Sunil K. "Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins : Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/2859.

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Анотація:
This thesis titled, “Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins: Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond”, describes two important studies. The first is to gain a thorough understanding of the nature of interactions that govern cisPro stability at Pro-Aro sequences, which described in the first four chapters. The final chapter describes the synthesis of novel 4-carbon covalent surrogates for the peptide H-bonding interaction. Chapter 1: Local Interactions Governing cisPro Stabi
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34

Gupta, Sunil K. "Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins : Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond." Thesis, 2016. http://etd.iisc.ernet.in/handle/2005/2859.

Повний текст джерела
Анотація:
This thesis titled, “Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins: Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond”, describes two important studies. The first is to gain a thorough understanding of the nature of interactions that govern cisPro stability at Pro-Aro sequences, which described in the first four chapters. The final chapter describes the synthesis of novel 4-carbon covalent surrogates for the peptide H-bonding interaction. Chapter 1: Local Interactions Governing cisPro Stabi
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35

Cieplak-Rotowska, Maja. "Biophysical and molecular biology studies of proteins involved in gene silencing." Doctoral thesis, 2017. https://depotuw.ceon.pl/handle/item/2368.

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Анотація:
This thesis provides biophysical bases of the interactions between two proteins involved in microRNA (miRNA)-mediated silencing: CNOT1 and the silencing domain of GW182. The regulation of gene expression at the post-transcriptional level involves the crucial CCR4-NOT deadenylase complex, which deadenylates mRNA, and can also inhibit translation in an independent fashion. In miRNA-mediated silencing, the CCR4-NOT complex is brought into the vicinity of the target mRNA by the successive actions of the miRNA, the Argonaute protein and finally, the GW182 protein, which interacts directly with CCR4
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