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1
Al-Rasasi, Buthaina. "Nausea and vomiting in pregnancy, maternal nutrition and pregnancy outcome." Thesis, University of Surrey, 2003. http://epubs.surrey.ac.uk/843490/.
Повний текст джерелаАнотація:
Nausea and vomiting in pregnancy (NVP), which is known to affect nearly 70% of all pregnant women, has been associated with favourable pregnancy outcomes such as decreased risk of miscarriage, low birth weight and premature delivery. The aim of this research was to determine the mechanism by which these protective effects of NVP may be brought about. Women suffering from NVP may decrease their intake due to the symptoms, may increase their intake to alleviate symptoms, or may change the quality of their diet. Both a retrospective questionnaire survey (n=201) and a prospective cohort study (n=52) were carried out between April 1999 and August 2001. Women were recruited mainly from two GP clinics in Guildford. It was found from both studies that the prevalence of NVP in the Guildford area is similar to that reported in other studies. Although this study found no relationship between NVP and birth weight and gestational age, women with NVP had higher cord IGF-1 levels compared to women without NVP (p=0.044). In addition, duration of NVP was inversely related to birthweight to placental ratio (p=0.011). Forty three women provided complete dietary information. It was found that energy intakes did not differ between women who had NVP compared with women who had no NVP, however the quality of diet varied between women with NVP and those without NVP. This is probably due to the fact that women with NVP had a high risk of cravings and aversions in pregnancy, leading to the difference in intake of certain nutrients such as riboflavin, calcium, zinc and copper. The strong association between NVP and aversions in pregnancy (P= 0.026) found in the retrospective study could lend further support to the "Embryo protection" hypothesis, which states that NVP is a protective mechanism, which has evolved to prevent the mother from the ingestion of foods that could be harmful to the fetus. Further studies using larger sample sizes, covering a range of socio-economic status and different regions are needed before definite conclusions can be drawn.
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Swallow, Brian L. "Nausea and vomiting in pregnancy : psychological and social aspects." Thesis, University of Lincoln, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496084.
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Smith, Caroline Anne. "Acupuncture to treat nausea and vomiting in early pregnancy : a randomised controlled trial." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phs644.pdf.
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Mazzotta, Paolo. "Nausea and vomiting of pregnancy, misperception of drug use and major adverse events." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0005/MQ34080.pdf.
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Chou, Fan-hao. "The adaptation to pregnancy in Taiwanese women who experience different severities of nausea and vomiting." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3036170.
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Chandra, Kiran. "Development of a health-related quality of life (HRQL) instrument for nausea and vomiting in pregnancy (NVP)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ54162.pdf.
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Viljoen, Estelle. "A systematic review of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20265.
Повний текст джерелаАнотація:
Thesis (MNutr)--Stellenbosch University, 2012.ENGLISH ABSTRACT: Background: Nausea and vomiting during pregnancy (NVP) is a common medical condition. Due to possible harmful side-effects that conventional medicine may pose to the fetus, many mothers choose not to use it, and are left helpless against NVP. There is a need for alternative treatment to relieve NVP symptoms. Objectives: This systematic review (SR) investigated current evidence regarding ginger for the treatment of NVP. The primary objective was to assess the effectiveness of ginger in treating NVP. The secondary objective was to assess the safety of ginger during pregnancy, by identifying adverse events or side-effects. Search strategy: Electronic search of bibliographic databases (1966-February 2011). Selection criteria: Randomized controlled trials (RCTs) of the efficacy of ginger by any route, as treatment for NVP in pregnant women regardless of their age or stage of pregnancy. Data collection and analysis: The principal investigator and independent reviewer individually identified relevant studies, extracted data and assessed trial quality. Data analysis was performed using the RevMan5 software. Differences at the level of p<0.05 were considered to be statistically significant. Results: Eleven RCTs involving 1176 pregnant women were included. The quality of evidence was low, hence the high risk of bias and imprecision of results. Ginger significantly improved the symptoms of nausea when compared to placebo, when comparing the results of this SR to past SRs, and taking into account a meta-analysis performed on two relatively large included studies (mean difference (MD) 1.20, 95% confidence interval (CI) 0.56-1.84, p=0.0002, I2=0%). However, another meta-analysis on two smaller studies indicated no significant improvement in nausea. Ginger did not significantly improve nausea when compared to vitamin B6 (MD 0.34, 95% CI -1.52-2.20, p=0.7, I2=91%). Similarly, ginger did not significantly reduce the number of vomiting episodes during NVP, when compared to placebo, although there was a trend towards improvement (MD 0.72, 95% CI -0.03-1.46, p=0.06, I2=71%). Subgroup analyses performed seemed to favor the lower daily dosage of <1500mg ginger to possibly be more effective for the relief of nausea. Ginger did not pose a significant risk for spontaneous abortion when compared to placebo (RR 3.14, 95% CI 0.65-15.11, p=0.15; I2=0%), or to vitamin B6 (RR 0.49, 95% CI 0.17-1.42, p=0.19, I2=40%). Similarly, ginger did not pose a significant risk for the side effects of heartburn or drowsiness when compared to placebo or vitamin B6. When compared to dimenhydrinate, ginger posed a smaller risk for drowsiness (RR 0.08, 95% CI 0.03-0.18) and no increased risk for heartburn. Conclusions: This review suggests potential benefits of ginger in reducing nausea symptoms in pregnancy (bearing in mind the limited number of studies, variable outcome reporting and quality of evidence). Ginger did not have a significant impact on vomiting episodes, nor pose a risk for side effects or adverse events during pregnancy. Based on evidence from this SR, ginger could be considered a harmless and possibly effective alternative option for women suffering from the symptoms of NVP. Large RCTs are necessary to confirm the possible benefit of ginger as treatment for NVP.
AFRIKAANSE OPSOMMING: Agtergrond: Naarheid en vomering tydens swangerskap (NVS) is ‘n algemene mediese toestand. As gevolg van moontlike skadelike newe-effekte wat konvensionele medikasie kan veroorsaak vir die fetus, vermy baie moeders dit en word hulpeloos gelaat teen NVS. Dus is daar behoefte aan alternatiewe behandeling vir NVS. Doelwitte: Hierdie sistematiese literatuuroorsig (SO) het huidige literatuur ondersoek wat verband hou met gemmer vir behandeling van NVS. Die primêre doelwit was om effektiwiteit van gemmer as behandeling vir NVS te assesseer. Die sekondêre doelwit was om veiligheid van gemmer tydens swangerskap te assesseer, deur ongunstige gebeure en newe-effekte te identifiseer. Soektogstrategie: Elektroniese soektog van bibliografiese databasisse (1966-Februarie 2011). Seleksiekriteria: Verewekansigde gekontrolleerde proewe (RCTs) van gemmer deur enige roete as behandeling van NVS, in swanger vroue ongeag ouderdom of stadium van swangerskap. Dataversameling en –analise: Die hoof navorser en ‘n onafhanklike hersiener het individueel relevante studies geidentifiseer, data ekstraksie onderneem en studie-kwaliteit geassesseer. Data-analise is uitgevoer deur die RevMan5 sagteware te gebruik. Verskille by die vlak van p<0.05 was beskou as statisties betekenisvol. Hoof resultate: Elf RCTs waarby 1176 swanger vroue betrokke was, is ingesluit. Die studie-kwaliteit was swak, dus die hoë risiko vir sydigheid en onakkuraatheid van resultate. Gemmer het beduidend die simptome van naarheid verbeter in vergelyking met plasebo, wanneer die resultate van hierdie SO met vorige SO’s vergelyk word, en die meta-analise in ag geneem word wat op twee relatiewe groot ingeslote studies uitgevoer is (gemiddelde verskil (MD) 1.20, 95% vertrouens interval (VI) 0.56-1.84, p=0.0002,I2=0%). Kontrasterend, het ‘n ander meta-analise van twee kleiner studies geen beduidende verbetering in naarheid aangedui nie. Gemmer het nie beduidend naarheid verbeter wanneer dit met vitamien B6 vergelyk word nie (MD 0.34, 95% VI -1.52-2.20, p=0.7, I2=91%). Soortgelyk, het gemmer nie die aantal vomerings-episodes verminder, in verglyking met plasebo nie, maar daar was wel ‘n neiging na verbetering (MD 0.72, 95% VI -0.03-1.46, p=0.06, I2=71%). Die subgroup-analise blyk ten gunste te wees van die laer daaglikse dosis van <1500mg gemmer om meer effektief te wees vir die behandeling van naarheid. Gemmer het nie ‘n beduidende risiko ingehou vir spontane aborsie, wanneer dit vergelyk word met plasebo (relatiewe risiko (RR) 3.14, 95% VI 0.65-15.11,p=0.15;I2=0%), of vitamien B6 nie (RR 0.49, 95% VI 0.17-1.42,p=0.19;I2=40%). Soortgelyk, het gemmer nie ‘n beduidende risiko ingehou vir newe-effekte van sooibrand of duiseligheid, wanneer dit vergelyk word met plasebo of vitamien B6 nie. Wanneer dit vergelyk word met dimenhidrinaat, het gemmer ‘n kleiner risiko ingehou vir duiseligheid (RR 0.08, 95% VI 0.03-0.18) en geen verhoogde risiko vir sooibrand nie. Gevolgtrekkings: Hierdie SO dui ‘n potensiële voordeel van gemmer aan in vermindering van naarheid tydens swangerskap (inagnemend van die klein hoeveelheid studies, wisselende uitkomste-rapportering en studie-kwaliteit). Gemmer het nie ‘n beduidnede impak gehad op vomerings-episodes nie, en ook nie ‘n risiko ingehou vir newe-efekte of ongunstige gebeure tydens swangerskap nie. Volgens bewyse uit hierdie SO, kan gemmer beskou word as ‘n skadelose en moontlike effektiewe alternatiewe opsie vir vroue wat lei aan NVP. Grootskaalse RCTs is nodig om die moontlike voordeel van gemmer as behandeling vir NVS te bevestig.
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Chan, Ronna L. Olshan Andrew F. Savitz David A. "Maternal health exposures and pregnancy outcome examining symptoms of nausea and vomiting in early pregnancy, maternal caffeine consumption, and spontaneous abortion utilizing regression and propensity score methodologies /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2157.
Повний текст джерелаАнотація:
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.Title from electronic title page (viewed Feb. 26, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Maternal and Child Health reproductive epidemiology, School of Public Health." Discipline: Maternal and Child Health; Department/School: Public Health.
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Sartori, Julie A. "Morning sickness and the placenta." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2023. https://ro.ecu.edu.au/theses/2728.
Повний текст джерелаАнотація:
Background: Nausea and vomiting in pregnancy (NVP) is considered one of the ultimate reproductive health dilemmas and often misunderstood both biologically and conceptually. This phenomenon occurs in approximately eighty percent of pregnancies worldwide and there are many theories relating to the cause of symptoms, however, no origin has been identified. Morning sickness will be discussed primarily within a physiological framework that focuses on maternal characteristics, placental structure, and related birth outcomes. Interestingly, vomiting in pregnancy appears to be unique to the human species, which from an evolutionary medical perspective is thought to be the result of human adaptation to varying internal and external environments. Some human adaptations or the consequential effects of these adaptations are not always viewed as favourable, from our twenty-first century medical point of view. Women with an absence of NVP symptoms in pregnancy are understudied and therefore, an essential and informative addition to this cohort.
Aims: The primary focus of this research project was to investigate NVP in relation to maternal characteristics, placental structure, and birth outcomes in singleton pregnancies. This study also included an important subset of expectant mothers with no reported NVP symptoms. Characteristics of morning sickness for expectant mothers with pregnancies resulting from ART and non-ART conception were examined. Psychosocial outcome variables and morning sickness status were compared using three specific measures from the maternal health questionnaire (MHQ) [Social Provision Scale (SPS), Pregnancy Distress Scale (PDQ) and the Perceived Stress Scale (PSS)], and the Edinburgh Postnatal Depression Scale (EPDS) from the maternal medical records. Data generated from the MHQ, gross placental morphology, maternal and natal medical records were examined to determine the associations between morning sickness, placental structure, and birth outcomes (e.g., low birth weight, placental weight, and birth weight to placental weight ratio). A unique addition to this study was the consideration of the placental microbiome as a potential contributing factor to differences in women with different NVP status.
Methods: To investigate NVP characteristics and examine the role of the human placenta and NVP status, 625 expectant mothers with singleton pregnancies were recruited from two major hospitals in Perth, Western Australia. Pregnancies were the result of natural and assisted conception and expectant mothers participated in a cross- sectional survey consisting of a MHQ, and gross placental examination using gross morphologic analysis. On completion of placental analyses, data from the maternal and natal medical records were collected and characteristics compared for women with differing nausea and vomiting status. The characteristics of NVP were identified through statistical analyses of the data, including significant medical, clinical, and psychosocial factors. Gross placental morphology measures and birth outcomes were compared according to NVP status.
Results: NVP was experienced by most expectant mothers in this cohort (79%) with 21% of women experiencing no NVP and 3% clinically diagnosed with hyperemesis gravidarum (HG). Nausea was the most prevalent symptom followed by food avoidance and women were more likely to report the frequency of these symptoms as continuous, while retching and vomiting were episodic in nature. Symptoms were self-rated as moderate to severe, and all risk factors were positively correlated with NVP. Women with HG recorded associated variables including increased symptom frequency and severity, medication use and a majority of the risk factors from the MHQ. The severity and frequency of symptoms were significantly associated with a number of maternal characteristics including age of menarche, increased maternal weight/obesity on first antenatal booking and admission for delivery of the baby.
Increased psychosocial measures noted for women with NVP were related to the frequency and severity of symptoms. This was consistent for women who experienced HG and had pregnancies resulting from ART. ART treatments were also associated with an increased frequency and severity of symptoms. Women experiencing NVP reported higher overall scores for the Pregnancy Distress Questionnaire and Perceived Stress Scale when compared to women who had no NVP, and evaluation of the Social Provision Scale identified women with NVP had lower self-rating scores for Nurturance and Attachment.
Women in this study delivered normal healthy babies, with normal BW/PWR and ponderal index ranges. Placental measures were similar for NVP status groups across this cohort and a majority fell within the 10th and 90th centiles for BW and placental weight. Evaluation of placental weight for women with clinically diagnosed HG in ART and non-ART pregnancies found that women who conceived naturally and experienced HG had an increased trimmed placental weight (grams). Women with HG who conceived using ART were more likely to have a lower placental weight.
This was the first study to explore the association between the placental amniochorionic microbiome and morning sickness status in women with singleton pregnancies. Significant differences in microbial diversity were noted between NVP status groups. Women with NVP had a higher species diversity and those in the No NVP group having a lower microbial diversity.
Clinical relevance: This comprehensive study has produced new and insightful information, highlighting the role of maternal characteristics and placental development in maternal health and birth outcomes. A detailed examination of NVP and the relationship between NVP symptoms, have highlighted the need for research that explores symptom frequency and severity rather than the presence or absence of symptoms alone. Examination of medical and clinical characteristics for women with and without NVP have provided new theoretical understanding and this current research provides evidence-based findings linking NVP and placental anatomy that are important for perinatal health. Future research examining the biological mechanisms and NVP symptom expression would be valuable. As part of reproductive health, ongoing research that promotes clinical understanding and the effective management of nausea and vomiting in pregnancy will decrease patient distress and foster practitioner confidence. Documentation of key concepts related to the physiology of nausea and vomiting in pregnancy can provide an understanding of the pathways that lead to NVP. Expectant mothers will be empowered by having access to updated information promoting maternal and natal health outcomes. Importantly, information should be provided to partners, family, friends, and caregivers to assist, nurture and support all expectant mothers.
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Hines, Sonia Jane. "Aromatherapy for postoperative nausea and vomiting." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/60245/1/Sonia_Hines_Thesis.pdf.
Повний текст джерелаАнотація:
Background: Postoperative nausea and vomiting is one of the most common adverse reactions to surgery and all types of anaesthesia and despite the wide variety of available antiemetic and anti-nausea treatments, 20-30% of all patients still suffer moderate to severe nausea and vomiting following general anaesthesia. While aromatherapy is well-known and is used personally by nurses, it is less well utilised in the healthcare setting. If aromatherapy is to become an accepted adjunct treatment for postoperative nausea and vomiting, it is imperative that there is both an evidence base to support the use of aromatherapy, and a nursing workforce prepared to utilise it.
Methods: This involved a Cochrane Systematic Review, a Delphi process to modify an existing tool to assess beliefs about aromatherapy to make it more relevant to nursing and midwifery practice, and a survey to test the modified tool in a population of nurses and midwives.
Findings: The systematic review found that aromatherapy with isopropyl alcohol was more effective than placebo for reducing the number of doses of rescue antiemetics required but not more effective than standard antiemetic drugs.
The Delphi panel process showed that the original Beliefs About Aromatherapy Scale was not completely relevant to nursing and midwifery practice. The modified Nurses' Beliefs About Aromatherapy Scale was found to be valid and reliable to measure nurses' and midwives' beliefs about aromatherapy. Factor analysis supported the construct validity of the scale by finding two sub-scales measuring beliefs about the 'usefulness of aromatherapy' and the 'scientific basis of aromatherapy'. Survey respondents were found to have generally positive beliefs about aromatherapy, with more strongly positive beliefs on the 'usefulness of aromatherapy' sub-scale.
Conclusions: From the evidence of the systematic review, the use of isopropyl alcohol vapour inhalation as an adjunct therapy for postoperative nausea and vomiting is unlikely to be harmful and may reduce nausea for some adult patients. It may provide a useful therapeutic option, particularly when the alternative is no treatment at all.
Given the moderately positive beliefs expressed by nurses and midwives particularly about the usefulness of aromatherapy there is potential for this therapy to be implemented and used to improve patient care.
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Bossaer, John B. "Olanzapine for Chemotherapy-Induced Nausea and Vomiting." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2312.
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Amah, O. O. E., and D. Okoye. "Prevention of perioperative nausea and vomiting during epidural anesthesia." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/58267.
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Gan, T. J. "Propofol for the management of postoperative nausea and vomiting (PONV)." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1445292/.
Повний текст джерелаАнотація:
Postoperative nausea and vomiting (PONV) is one of the most common complications following surgery. Despite better anaesthetic techniques, and the availability of newer generations of antiemetics, the incidence of PONV is still as high as 60-70% in high-risk subjects. Patients rated symptoms of nausea and vomiting as highly undesirable and are willing to pay out of pocket a substantial amount for an effective antiemetic. PONV also has major economic implications, prolonging recovery room and hospital stay, and in some cases, increases patient morbidity. Propofol is an intravenous anaesthetic which gained rapid popularity due to its favourable pharmacokinetic and pharmacodynamic profile. In particular, it is associated with rapid recovery, making it the intravenous anaesthetic agent of choice especially in ambulatory anaesthesia. Previous studies have demonstrated that total intravenous anaesthesia with propofol is associated with a lower incidence of PONV when compared with inhalational anaesthetic. However, it is unclear regarding the dose response of propofol when used as an antiemetic, and how propofol should be administered in the perioperative period for its antiemetic effects. The over arching goal of this MD thesis is to examine the use of propofol for its antiemetic properties. First, we assessed the extent of clinical practice of using propofol for its antiemetic effects among US anaesthesiologists. Next, we determine the dose response of propofol for its antiemetic effects. We examined the efficacy of propofol when used as antiemetic prophylaxis as well as for the treatment of established PONV. Different regimens of propofol administration were assessed for its prophylactic antiemetic effects. Treatment of established PONV was assessed using a patient controlled antiemetic system. We also determined the use of propofol in a multimodal PONV prevention strategy as well as its use in paediatric population. The main objective of these series of investigations was to systematically determine the antiemetic effects of propofol and recommend how propofol should be used in clinical practice.
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Oddby, Muhrbeck Eva. "Postoperative nausea and vomiting in women : an unglamorous aspect of anaesthesia /." Stockholm, 2002.
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Chow, Hoi-yee Elaine, and 周愷怡. "A clinical guideline on the use of acustimulation on managing adult orthopaedic patients with postoperative nausea and vomiting." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46581613.
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Magni, Bridget. "Incidence of intraoperative nausea and vomiting during spinal anaesthesia for caesarean section." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20291.
Повний текст джерелаАнотація:
The incidence of intraoperative nausea and vomiting during spinal anaesthesia for caesarean section. Background: Nausea and vomiting (IONV) during spinal anaesthesia (SA) for caesarean section (CS) is unpleasant and may interfere with surgery. We studied the incidence of IONV during elective CS, as well as the influence of ethnicity on this outcome. Methods: Two hundred and fifty eight healthy term patients undergoing SA for elective CS were recruited to this prospective observational study conducted at two Cape Town Level 2 hospitals. Standard practice was employed for SA for CS at UCT (University of Cape Town): 2 mL hyperbaric bupivacaine plus 10 μg fentanyl at the L3/4 interspace, and 15 mL/kg cry stalloid co - load. Spinal hypotension was managed with phenylephrine boluses according to a standard protocol. Nausea and/or vomiting were treated by restoration of blood pressure, and metoclopramide. Intraoperative complaints of nausea, and vomiting, were noted. Patients were also interviewed postoperatively as to any experience of intraoperative - or previous history of nausea. Results: Of the 258 patients enrolled in the audit, 112 (43.4%) were non - African and 146 (56.6%) were Black African patients. The overall incidence (95% CI) of nausea was 32% (0.27 - 0.38), with 20% occurring prior to - and 11% after the delivery. The overall incidence of vomiting was 7% (0.05 - 0.11), with 3.2% occurring prior to, and 3.8% after, delivery. The incidence of nausea and/or vomiting was 33% (0.28 - 0.40). Black Africans experienced significantly less nausea than non - African patients (36/145 [24.8%] vs 47/112 [42.0%] respectively, p = 0.004). There was no significant difference in the incidence of vomiting (10/14 5 [6.8%] vs. 8/112 [7.1%] respectively, p = 0.865). The odds of experiencing intraoperative nausea for patients with any blood pressure value <70% of baseline, were 2.46 (95% CI 1.40 - 4.33). Conclusions Though in keeping with international standards, the clinically significant incidence of nausea and/or vomiting of 33% requires adjustments to the management protocol for spinal hypotension. The inclusion of ethnicity as a risk factor for nausea during SA for CS should be considered.
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Alsup, Natalie Marie. "Nitrous Oxide and Post-Operative Nausea and Vomiting: A Randomized Controlled Trial." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471210114.
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Maubach, Karen Ann. "The role of tachykinins in synaptic transmission in the nucleus tractus solitarius." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306881.
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Lau, Pui-kwan, and 劉姵君. "A clinical guideline for using acupressure to reduce postoperative nausea and vomiting in adult surgical patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46582186.
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Seibert, Laurel, Sierra Vig, and Myke Green. "Impact of Olanzapine on Refractory Chemotherapy-Induced Nausea and Vomiting: a Retrospective Study." The University of Arizona, 2013. http://hdl.handle.net/10150/614310.
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Class of 2013 AbstractSpecific Aims: To describe the outcomes of olanzapine in the treatment of refractory chemotherapy-induced nausea and vomiting (CINV). Methods: Data were collected regarding demographic information, chemotherapy regimen, CINV prophylaxis, rescue antiemetics, and olanzapine usage for subjects, age 18-79, who were admitted to the University of Arizona Medical Center for chemotherapy and received at least one dose of olanzapine for CINV between January 2008 and January 2012. The primary outcome measure was the number of rescue antiemetics required following the first dose of olanzapine (greater than 10 doses was considered treatment failure). Comparisons using chi square to determine if differences existed with respect to the level of chemotherapy emetogenicity and demographic information were conducted. Main Results: No statistical difference between chemotherapy regimens of high versus low-to-moderate emetogenicity was seen (P=0.79). However, 7 of 10 (70%) subjects receiving highly emetogenic chemotherapy achieved success and 15 of 23 (65%) subjects receiving low-to-moderately emetogenic chemotherapy achieved success. No statistical differences appeared when evaluating usage of 1 versus 2 or more prophylactic antiemetics (P=0.77), men versus women (P=0.08), and age over 50 versus 50 years or younger (P<0.99). Conclusion: This study demonstrated a trend towards greater emetic control with the addition of olanzapine in patients failing first-line antiemetic pharmacotherapy. Additionally, a trend towards greater emetic control was seen in women. The rates of success among all groups may suggest benefit to adding olanzapine to subjects experiencing refractory CINV. Due to the limited sample size and retrospective methodology of the study, the use of olanzapine in refractory CINV merits further research with large, prospective studies directly comparing addition of olanzapine to other appropriate antiemetics.
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Forren, Jan Odom. "POST DISCHARGE NAUSEA AND VOMITING IN AMBULATORY SURGICAL PATIENTS: INCIDENCE AND MANAGEMENT STRATEGIES." Lexington, Ky. : [University of Kentucky Libraries], 2009. http://hdl.handle.net/10225/1141.
Повний текст джерелаАнотація:
Thesis (Ph. D.)--University of Kentucky, 2009.Title from document title page (viewed on May 12, 2010). Document formatted into pages; contains: vii, 166 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 141-157).
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Ericson, Jonna, and Eva Klaesson. "Komplementära behandlingsmetoder vid cytostatikarelaterat illamående och kräkning." Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-2272.
Повний текст джерелаАнотація:
Illamående och kräkning är förekommande biverkningar hos patienter med cancer som behandlas med cytostatika och är därmed tillstånd som sjuksköterskan kommer i kontakt med. Om patientens illamående och kräkning inte förebyggs kan det leda till konsekvenser som att patienten blir dehydrerad, tappar aptiten, blir undernärd och försvårar skadad vävnad att återhämta sig från cytostatikabehandling. Trots att de flesta patienter får antiemetika lyckas inte deras illamående och kräkning förebyggas. Syftet var att belysa komplementära behandlingsmetoder vid cytostatikarelaterat illamående och kräkning. Studien är utförd som en litteraturstudie och baserad på 14 vetenskapliga studier. Resultatet visar att komplementära behandlingsmetoder har ett visst vetenskapligt stöd och är ett bra komplement till antiemetika. Akupressur är den behandlingsmetod som är effektivast för att förebygga cytostatikarelaterat illamående och kräkning. Även akustimulation, elektroakupunktur och avslappning minskar patienternas illamående och kräkning. Mer forskning behövs för att ge mer styrka åt de olika komplementära behandlingsmetoder, eftersom sjuksköterskans arbete måste utföras utifrån vetenskap och beprövad erfarenhet. Genom att sjuksköterskan får ökad kunskap om hur cytostatikarelaterat illamående och kräkning förebyggs kan patientens lidande minska.
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Enblom, Anna. "Nausea and vomiting in patients receiving acupuncture, sham acupuncture or standard care during radiotherapy." Doctoral thesis, Linköpings universitet, Omvårdnad, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17237.
Повний текст джерелаАнотація:
Background and aim: Many patients with cancer experience emesis (nausea and vomiting) during radiotherapy. The overall aim of this thesis was to improve the situation for patients with risk for emesis during radiotherapy, by evaluating emesis in patients receiving verum (genuine) acupuncture, sham (simulated) acupuncture or standard care during radiotherapy. Methods: In study I, a cross-sectional sample (n=368) treated with radiotherapy over various fields answered a study-specific questionnaire. In study II, 80 healthy volunteers were randomized to receive needling with verum acupuncture or non-penetrating telescopic sham needles by one of four physiotherapists. In study III, 215 patients were randomly allocated to verum (n=109) or non-penetrating telescopic sham (n=106) acupuncture during their entire radiotherapy period over abdominal or pelvic fields. The same 215 patients were also included in study IV. They were compared to 62 patients irradiated over abdominal or pelvic fields, selected from study I. Results: In study I, the weekly prevalence of nausea was 39 % in all radiotherapy-treated patients and 63 % in abdominal or pelvic irradiated patients. Age younger than 40 years and previous experience of nausea in other situations were characteristics associated with an increased risk for nausea. Of the 145 nauseous patients, 34 % considered their antiemetic treatment as insufficient. Patients with nausea reported lower level of quality of life compared to patients free from nausea. In study II, most individuals needled with verum (68 %) or sham (68 %) acupuncture could not identify needling type, and that blinding result varied from 55 to 80 % between the four therapists. In study III, nausea was experienced by 70 % (mean number of days=10.1) and 25 % vomited during the radiotherapy period. In the sham group 62 % experienced nausea (mean number of days=8.7) and 28 % vomited. Ninety five percent in the verum and 96 % in the sham group believed that the treatment had been effective for nausea. In both groups, 67 % experienced other positive effects, on relaxation, mood, sleep or pain-reduction, and 89 % were interested in receiving the treatment again. In study IV, the weekly prevalence of nausea and vomiting was 38 and 8 % in the verum group, 37 and 7 % in the sham group and 63 and 15 % in the standard care group. The nausea difference between the acupuncture and the standard care cohort was statistically significant, also after overall adjustments for potential confounding factors. The nausea intensity in the acupuncture cohort was lower compared to the standard care cohort (p=0.002). Patients who expected nausea had increased risk for nausea compared to patients who expected low risk for nausea (Relative risk 1.6). Conclusions and implications: Nausea was common during abdominal or pelvic field irradiation in patients receiving standard care. Verum acupuncture did not reduce emesis compared to sham acupuncture, while reduced emesis was seen in both patients treated with verum or sham acupuncture. Health-care professionals may consider identifying and treating patients with increased risk for nausea in advance. The telescopic sham needle was credible. Researchers may thus use and standardize the sham procedure in acupuncture control groups. The choice of performing acupuncture during radiotherapy cannot be based on arguments that the specific characters of verum acupuncture have effects on nausea. It is important to further study what components in the acupuncture procedures that produce the dramatic positive but yet not fully understood antiemetic effect, making it possible to use those components to further increase quality of care during radiotherapy.
24
Russell, Rachael. "Nausea and vomiting : a history of signs, symptoms and sickness in nineteenth-century Britain." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nausea-and-vomiting-a-history-of-signs-symptoms-and-sickness-in-nineteenthcentury-britain(08b611ee-2425-4961-8fbd-46f1ecf38300).html.
Повний текст джерелаАнотація:
During the nineteenth century, as today, nausea and vomiting were common signs and symptoms of illness, the interpretation of which contributed to doctors' diagnostic, prognostic and therapeutic choices. At the core of this thesis lies the research question: how did medical understandings and management of nausea and vomiting change in the period 1800-1900? In addition to being signs of bodily disorder, nausea and vomiting constituted an individual, typically non-medicalised experience of sickness. As such, a secondary thesis question is: how were nausea and vomiting experienced, interpreted and responded to by sufferers? These questions are pursued through four key themes: physiology, vomit analysis, morning sickness and sea-sickness. Medical textbooks, journals, hospital case reports, newspapers, letters and diaries are the principal source base. Throughout the nineteenth century physiological explanations for nausea and vomiting followed a generally reductionist path. In the 1830s Marshall Hall's reflex theory encouraged new perceptions of the nervous mechanisms involved in nausea and vomiting, and helped stimulate their redefinition into local, central and peripheral causes. Changing physiological explanations for nausea and vomiting were also contemporaneous to the growth of microscopy. This thesis draws attention to the interest nineteenth-century practitioners showed in using vomited matters as pathological fluids. This is explored primarily through a case study of sarcina ventriculi, a vegetable microorganism discovered in fermenting vomit. Responses to this discovery showed that laboratory techniques were largely inapplicable to everyday occurrences of nausea and vomiting. Consequently, neither the increasing localisation of the causes of vomiting, nor interest in vomited matters as pathological fluids, contributed to specificity in diagnoses or treatments. This research thereby demonstrates the cumulative and overlapping nature of nineteenth-century medical cosmologies - 'bedside', 'hospital' and 'laboratory' - and the continuation of the 'clinical art'. The histories of morning sickness and sea-sickness contextualise medical understandings of nausea and vomiting in relation to these transient conditions. They bring to the fore perceptions of health and sickness and show that medical theory was often secondary to cultural beliefs and practices. Specifically, this thesis questions the medicalisation of pregnancy during the nineteenth century and uses experiences of sea-sickness to reveal new features of Victorian understandings of the mind-body relationship. This thesis shows that 'feeling sick' (nausea) was arguably as significant to contemporaries as actually 'being sick' (vomiting). It also confirms the complexity and fluidity of taken-for-granted terms such as: 'patient', 'sufferer', 'disease', 'illness' 'sign' and 'symptom', and, of course, 'sick'. Furthermore, it demonstrates the importance to historians of studying everyday, self-limiting illnesses and morbidity.
25
Lee, Jiyeon. "Exploring chemotherapy-induced nausea and vomiting: The symptoms, interventions, and relationship to functional status." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311334.
Повний текст джерела
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Andersson, Stina. "Gastric electrical stimulation studies in patients with intractable nausea and comiting /." Göteborg : Dept. of Internal Medicine, Institute of Medicine at Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, 2010. http://hdl.handle.net/2077/21862.
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27
Friedberg, Marc Alan. "The Effect of Pre-emergence Gastric Aspiration on Postoperative Nausea and Vomiting Following Abdominal Surgery." VCU Scholars Compass, 1988. http://scholarscompass.vcu.edu/etd/4681.
Повний текст джерелаАнотація:
An investigation was undertaken to determine the effect of pre-emergence gastric aspiration on the incidence of postoperative nausea and vomiting in abdominal surgery patients. Thirty female ASA I and ASA II patients were randomly assigned to either a control group (n = 16) or a treatment group (n = 14). Those patients in the treatment group received pre-emergence gastric aspiration with a suction catheter; those patients in the control group did not. The incidence of postoperative nausea and vomiting was determined at various time intervals. Data were analyzed using Student's t test and the Chi-square statistic. Results indicated that there was no difference in the occurrence of postoperative nausea and vomiting between the groups.
28
Jokela, Ritva. "Prevention of postoperative nausea and vomiting : studies on different antiemetics, their combinations and dosing regiments." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/jokela/.
Повний текст джерела
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Moradian, Saeed. "Management of chemotherapy-induced nausea and vomiting : a pilot randomised controlled trial using Nevasic audio programme." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/management-of-chemotherapyinduced-nausea-and-vomiting-a-pilot-randomised-controlled-trial-using-nevasic-audio-programme(29571f19-466c-4fdd-a9b9-725cc2634889).html.
Повний текст джерелаАнотація:
Major advances in antiemetic therapy have been made over the past two decades. Despite these advances in antiemetic management, nausea and vomiting are still important problems in clinical practice, and approximately 50% of patients receiving chemotherapy still experience nausea and/or vomiting, highlighting the need for further developments in the field. Non-pharmacological interventions are suggested as possible adjuncts to standard anti-emetic therapy. A recently developed non-pharmacological intervention to alleviate nausea and vomiting is Nevasic, which may have potential to reduce CINV and improve management of these symptoms.This pilot trial was run to examine the feasibility of implementing and conducting a randomised controlled trial using Nevasic programme. In addition, the study aimed to evaluate the acceptability and potential effect of Nevasic on cancer patients undergoing chemotherapy. Ninety nine adult female breast cancer patients who had been prescribed a course of moderately high emetogenic chemotherapy were randomised to usual care (standard anti-emetics) plus one of (1) intervention group (using Nevasic), (2) attention group (listening to music), and (3) control group, receiving no additional intervention. Data were collected daily using the Rhodes Index of Nausea, Vomiting and Retching (INVR) and a structured diary questionnaire. The EORTC QLQ-C30 (and BR23) were used at baseline and day 6 post chemotherapy. Data were collected from cancer centres affiliated to Mashhad University of Medical Sciences in Mashhad, Iran.The findings from the trial highlight that conducting a non-pharmacological intervention using such an audio programme is feasible, although difficulties and limitations exist. This study did not detect any evidence for the effectiveness of Nevasic on CINV; however, the results show statistically significant less use of anti-emetics (post-chemotherapy) (p=0.03) and borderline non-significant (p=0.06) better global health status in Nevasic group. Further studies are required to investigate its implications from other perspectives such as use of anti-emetics - rather than looking only at the "level of nausea and/or vomiting" perspective.
30
Malton, Samuel R. "Assessing the risk of chemotherapy toxicity and hospital admission due to toxicity: A study of acute chemotherapy toxicity and related hospital admission in a large UK teaching hospital, based on proactive telephone assessment patients." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17448.
Повний текст джерелаАнотація:
Introduction: Acute chemotherapy toxicity is common and can have negative
effects for the patient and health economy and hospitalisation can be
necessitated.
Aims: To identify the incidence of toxicity and admission, and predictors of
toxicity occurrence, severity, hospitalisation and length of stay.
Method: Data was obtained from a proactive telephone assessment of acute
toxicity 24 hours after administration of a first cycle of chemotherapy to patients
in a large UK NHS teaching hospital.
Results: 1539 patients were studied and the overall incidence of toxicity was
35.6% (530 patients). Disease site and number of chemotherapy agents given
were shown to predict toxicity, with breast and upper gastrointestinal cancers
having a higher likelihood of toxicity. Disease was predictive of toxicity grade,
with urology, gynaecology and lung cancer patients experiencing higher grades
of toxicity than other tumour sites. The rate of hospital admission due to toxicity
was 13.1% (203 patients) and median length of stay 3 days (1-28). The risk of
admission had some risk factors in common with toxicity. Disease and the
number of drugs in the regimen affected the risk of admission, with
gynaecology, head and neck and lung cancer patients and patients who
received 3 drugs having a higher likelihood of admission. Predictors in the subgroups
of breast, colorectal and lung cancer patients did not differ greatly from
the whole population and the number of drugs was shown to be a predictor of
nausea, vomiting and fatigue when explored as secondary outcomes.
Conclusion: The research partly addressed the main aim and highlighted
areas where further research is required.
Keywords
31
Tramer, Martin Richard. "Meta-analytical methods applied to both efficacy and adverse events (with special reference to nausea and vomiting)." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363765.
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Crystal, Susan. "Effect of early pregnancy vomiting on offspring salt taste preference /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9014.
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33
Kassel, Kareem. "The Incidence of Dysesthesia When Droperidol is Used for Prophylaxis of Post Operative Nausea and Vomiting." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/221246.
Повний текст джерелаАнотація:
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.Background: Multiple therapeutic regimens are used in an effort to attenuate the incidence of postoperative nausea and vomiting (PONV). Some drugs (e.g. dexamethasone, droperidol and scopolamine) are given preoperatively for prophylaxis in patients who are at increased risk of developing PONV. The use of droperidol has been associated with a relatively high incidence of dysesthesias (30% to 70%) in the outpatient setting, but we have not observed dysesthesias in most patients who receive it perioperatively. HYPOTHESIS: The incidence of dysesthesias in the perioperative period is less than that reported in the outpatient environment. Purpose: The primary goal was to determine the incidence of dysesthesia in patients treated with droperidol perioperatively for PONV. Secondary goals were to determine efficacy of droperidol for preventing PONV and the effect of droperidol on anxiety Methods: 30 patients who were at moderate to severe risk of developing PONV and met no exclusion criteria were asked to participate in the study. The consented patients completed a survey just prior to the intravenous administration of 0.625 mg of droperidol. 6 The survey was repeated 1 hour after the patient was admitted to the PACU Results: None of the patients reported dysesthesia (0%, p<.001). Patients also reported an average 2.2 point reduction on their 1-10 anxiety level after surgery and no patients complained of PONV. Conclusion: Dysesthesia from droperidol is much less common in the perioperative setting than has been reported in the outpatient setting. Based on result, low dose droperidol is expected to prove less likely to cause dysesthesias when used in the intraoperative setting for prophylaxis of PONV than reported in emergency departments and oncology clinics.
34
Lou, Yan. "Self-management of cancer treatment-related fatigue, nausea, vomiting and oral mucositis in Chinese cancer patients." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/44127/1/Yan_Lou_Thesis.pdf.
Повний текст джерелаАнотація:
Background: Treatment-related symptoms continue to place a significant burden on many cancer patients. Many side effects require patients to engage in a range of self-management actions. While some studies have explored self-management of treatment-related side effects in Western settings, very few studies were identified that described the self-management practices of cancer patients in China. Objective: The purposes of this study are to: (1) Investigate Chinese cancer patients. self-management behaviours in dealing with the fatigue, nausea/vomiting and oral mucositis that result from treatment, as well as the perceived effectiveness of these behaviours and related self-efficacy in performing them. (2) Explore factors influencing symptom self-management behaviours using the Cancer Symptom Self-management Framework based on Grey, Knafl and McCorkle.s (2006) self-management framework as a guide. Methods: This study was divided into two phases. Phase One consisted of the translation and modification of two instruments. The adaptation of these instruments to ensure applicability in the Chinese context was achieved through semi-structured interviews with six cancer patients, and content evaluation with eight experienced oncology nurses. A pilot study was conducted with nine cancer patients to trial the questionnaire set in the Chinese context. Based on the results of Phase One, Phase Two involved a cross-sectional survey of Chinese cancer patients undergoing cancer treatment using these instruments. A total of 277 chemotherapy patients with fatigue and/or nausea and vomiting, and 100 radiotherapy patients with oral mucositis were surveyed. Results: Participants in this study reported a variety of self-management behaviours to cope with fatigue, nausea, vomiting and oral mucositis. There are some consistencies as well disparities between strategies that are frequently used and those rated as effective. For fatigue self-management, participants were more likely to use strategies related to rest and sleep, while activity enhancement strategies were rated as achieving higher relief. For nausea and vomiting self-management, dietary modification and taking medication were most frequently used and rated as moderately effective. Psychological strategies were used by more than a third of participants and were rated as mildly effective. Some other infrequently used strategies, such as distraction by keeping busy and acupressure, were rated as moderately effective. For oral mucositis self-management, having soft, bland food and keeping the mouth moisturised were most frequently reported and they were rated as achieving moderate relief. A prescribed mouthwash was used by most but not all participants and brought moderate relief. In general, patients had low-to-moderate self-efficacy in nausea and vomiting self-management behaviours, moderate self-efficacy in fatigue self-management behaviours, and low-to-moderate self-efficacy in oral mucositis self-management behaviours. In terms of the factors influencing symptom self-management, different predictors were identified affecting engagement in fatigue, nausea/vomiting and oral mucositis self-management behaviours. Self-efficacy scores of different behaviours were consistently found to be a positive predictor of the relief level from corresponding behaviours, after controlling for other variables. Perceived social support from health care professionals was identified as an important factor influencing nausea and vomiting self-management behaviours, while neighbourhood support was important for fatigue self-management. In addition, symptom distress was identified as an important factor influencing nausea and vomiting self-management. Conclusion: Similar to reports from overseas, Chinese cancer patients initiate a wide range of self-management behaviours in response to treatment-related side effects. While some behaviours were reported to provide relief, many did not. Given these results, this study has a number of practical implications for health care professionals, particularly in relation to developing tailored self-management programs for fatigue, nausea, vomiting and oral mucositis. Additionally, this study suggests a number of theoretical implications and directions for future research. It is envisaged that these recommendations may pave the way for further studies understanding and promoting cancer symptom self-management in Chinese people affected by cancer.
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Pompeo, Daniele Alcalá. "Validação do diagnóstico de enfermagem náusea no período pós-operatório imediato." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/83/83131/tde-20082012-152826/.
Повний текст джерелаАнотація:
Este estudo teve como objetivos analisar o conceito náusea em pacientes no período pósoperatório imediato; avaliar a validade de conteúdo e clínica do diagnóstico de enfermagem Náusea no período pós-operatório imediato, considerando-se o modelo de Fehring; identificar a incidência do referido diagnóstico em pacientes no período pós-operatório imediato; verificar possíveis associações entre os antecedentes de náusea obtidos na análise de conceito e os identificados nos pacientes com náusea no pós-operatório imediato e verificar a frequência de ocorrência das características definidoras principais e secundárias do diagnóstico Náusea. A pesquisa foi desenvolvida em três etapas: análise de conceito, validação de conteúdo e validação clínica. A análise de conceito seguiu as oito fases propostas por Walker a Avant: selecionar o conceito, definir o objetivo da análise, identificar a utilização do conceito, definir atributos definidores, desenvolver casos-modelos, desenvolver outros casos, identificar antecedentes e consequentes e verificar as referências empíricas. Essa etapa foi fundamental para a realização das etapas posteriores (validação de conteúdo e validação clínica), permitindo a construção de definições operacionais e a elaboração de instrumentos de coleta de dados mais direcionados ao cenário do paciente com náusea no período pós-operatório. Participaram da validação de conteúdo 52 expertos que responderam a um instrumento que continha dados de identificação profissional e de validação do diagnóstico de enfermagem Náusea (enunciado, definição, posição que ocupa na estrutura taxonômica e características definidoras, descritas em uma escala tipo Likert). A maioria dos expertos considerou o domínio 12 (Conforto), a classe 1 (conforto físico) e o enunciado (náusea) adequados ao diagnóstico. Foram sugeridas modificações na definição atual do referido diagnóstico de enfermagem. Quatro características definidoras foram consideradas principais (relato de náusea, salivação aumentada, aversão à comida e sensação de vômito) e oito foram denominadas secundárias (deglutição aumentada, gosto amargo na boca, palidez, taquicardia, diaforese, sensação de calor e frio, alterações da pressão arterial e dilatação pupilar). Na etapa de validação clínica, 106 pacientes foram incluídos na amostra. Para a coleta de dados, foram utilizados o questionário de avaliação pré, intra e pósoperatória e a Escala Hospitalar de Ansiedade e Depressão. A náusea foi avaliada em duas etapas: 1) análise das manifestações objetivas (dois enfermeiros simultaneamente) e 2) subjetivas (um enfermeiro). A incidência de náusea foi de 21,70% e, na maioria das vezes, de moderada intensidade. Os antecedentes associados à presença de náuseas no pós-operatório foram: sexo, idade, tipo de anestesia, presença de dor, movimentação e alimentação pósoperatória e odores nocivos. Na etapa 1, a característica definidora denominada principal foi relato de náusea, e as manifestações secundárias foram sensação de vômito, palidez e deglutição aumentada. O índice de concordância variou de 86,95% a 100,00%. Na etapa 2, as características consideradas principais foram relato de náusea e sensação de vômito, e as características definidoras secundárias identificadas foram salivação aumentada e sensação de calor e frio. Os escores totais do diagnóstico de enfermagem Náusea foram de 0,79 e 0,73 para as validações de conteúdo e clínica respectivamente, considerado válido para a Taxonomia da North American Nursing Diagnosis Association - International (NANDA-I). Concluiu-se que o relato de náusea, sensação de vômito, palidez, salivação aumentada, deglutição aumentada e sensação de calor e frio são fortes indicativos do diagnóstico de enfermagem Náusea.The aims of this study were to analyze the nausea concept in patients during the immediate postoperative period; to assess the content and clinical validity of the nursing diagnosis nausea in the immediate postoperative period, considering Fehring\'s model; to identify the incidence of this diagnosis in patients during the immediate postoperative period; to check for possible associations between the nausea antecedents obtained in the concept analysis and those identified in patients with immediate postoperative nausea and to verify the frequency of the primary and secondary defining characteristics of the Nausea diagnosis. The research was developed in three phases: concept analysis, content validation and clinical validation. The concept analysis followed the eight phases proposed by Walker and Avant: select the concept, define the aim of the analysis, identify the use of the concept, define defining attributes, develop model cases, develop other cases, identify antecedents and consequences and check empirical references. This phase was fundamental to accomplish further phases (content validation and clinical validation), permitting the construction of operational definitions and the elaboration of data collection instruments that were better directed at the context of postoperative nausea patients. Fifty-two specialists participated in the content validation, who answered an instrument with professional identification data and the validation of the nursing diagnosis nausea (wording, definition, position in taxonomic structure and defining characteristics, described on a Likert scale). Most experts considered domain 12 (Comfort), class 1 (physical comfort) and the wording (nausea) adequate for the diagnosis. Modifications were suggested in the current definition of the referred nursing diagnosis. Four defining characteristics were considered primary (reported nausea, increased salivation, aversion toward food and gagging sensation), while eight were called secondary (increased swallowing, sour taste in the mouth, pallor, tachycardia, excessive sweating, feeling hot and cold, blood pressure alterations and pupil dilation). In the clinical validation phase, 106 patients were included in the sample. For data collection the pre, intra and post-operative assessment questionnaire and the Hospital Anxiety and Depression Scale were used. Nausea was assessed in two phases: 1) analysis of objective manifestations (two nurses simultaneously) and 2) subjective (one nurse). The incidence level of nausea corresponded to 21.70%, in most cases of moderate intensity. The following antecedents were associated with the presence of nausea and vomiting: gender, age, anesthesia type, presence of pain, postoperative movements and meals and harmful smells. In phase 1, the defining characteristic that was considered primary was reported nausea and the secondary manifestations were gagging sensation, pallor and increased swallowing. Agreement levels ranged between 86.95% and 100.00%. In phase 2, reported nausea and gagging sensation were considered primary characteristics, while increased salivation and feeling hot and cold were identified as secondary defining characteristics. The total scores of the nursing diagnosis Nausea corresponded to 0.79 and 0.73 for the content and clinical validations, respectively, which are considered valid for the Taxonomy of the North American Nursing Diagnosis Association - International (NANDA-I). In conclusion, reported nausea, gagging sensation, pallor, increased salivation, increased swallowing and feeling hot and cold are strong signs of the nursing diagnosis Nausea.
36
Wong, So-yan Christina, and 黃素欣. "A guideline on the use of acupressure for chemotherapy-induced nausea and vomiting in adult cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44626812.
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Chung, Wu Tu. "Estudo prospectivo do valor da acupuntura no controle da náusea e vômitos em pacientes de câncer de mama submetidas a quimioterapia adjuvante." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-24102007-154453/.
Повний текст джерелаАнотація:
O objetivo deste estudo é avaliar a eficácia de duas técnicas de acupuntura no controle da náusea e vômito em pacientes portadoras de Carcinoma Invasivo de mama, submetidas à quimioterapia anti-neoplásica. Foram incluídas no estudo 64 pacientes no período de março de 2003 a fevereiro de 2007, do Hospital A.C. Camargo com diagnóstico anatomopatológico de carcinoma invasivo da mama, candidatas à quimioterapia adjuvante com esquemas que incluem doxorrubicina e ciclofosfamida. O estudo foi realizado no primeiro ciclo de quimioterapia. As pacientes foram randomizados em 3 grupos: As pacientes do grupo A, receberam tratamento antiemético convencional com medicamentos. As pacientes do grupo B, receberam o tratamento antiemético convencional e aplicação de acupuntura clássica. As pacientes do grupo C, receberam tratamento convencional e aplicação de acupuntura auricular. As pacientes foram submetidas à auto-avaliação nos primeiros 21 dias após o início da quimioterapia, e conforme os critérios da Common toxicity criteria of the National Cancer Institute (NCI CTC), preencheram a ficha de coleta de dados em relação à náusea e vômito neste período. Quanto à náusea do primeiro ao sétimo dia, encontramos pelo teste de Kruskal-Wallis diferença significativa (p=0.040), sugerindo que a acupuntura diminui a intensidade de náusea deste período, e quanto à duração de dias de pior intensidade também foi significativo (p=0,037) ou seja a acupuntura diminui os dias de pior intensidade.Quando utilizamos o teste de Mann-Whitney encontramos diferença significativa da intensidade de náusea somente entre os grupos A e B (p=0,013), significando que a acupuntura clássica diminui a intensidade de náusea em relação ao grupo controle. Em relação aos dias de pior intensidade de náusea encontramos diferença entre os grupos A e B (p=0,043) e entre grupos B e C (p=0,010) ou seja, a acupuntura clássica diminui os dias de pior intensidade de náusea em relação aos grupos controle e acupuntura auricular. Quanto à gravidade do vômito, do primeiro ao sétimo dia, encontramos pelo teste de Kruskal-Wallis diferença significativa (p=0,036) entre os grupos, sugerindo que a acupuntura diminui a gravidade de vômitos. Pelo teste de Mann-Whitney entre os grupos A e B encontrou-se diferença significativa (p=0,017), ou seja, a acupuntura clássica diminui a gravidade de vômitos comparado ao grupo controle. Quanto ao número de dias de vômito de pior grau entre o primeiro e o sétimo dia encontramos ao aplicar o teste ANOVA diferença significativa entre os grupos (p=0,029), sendo que a acupuntura diminui o número de dias com vômito. O teste t aplicado para os grupos em pares revelou entre grupos A e B (p=0,035), portanto, a acupuntura clássica diminui o número de dias de vômito comparado ao grupo controle. Ao estudarmos a intensidade de náusea entre oitavo e vigésimo primeiro dia encontramos pelo teste de Kruskal-Wallis entre os grupos diferença significativa (p=0,022), sendo que a acupuntura diminui a náusea entre oitavo e vigésimo primeiro dia. Pelo teste de Mann-Whitney entre grupos aos pares encontrou-se diferença significativa entre os grupos A e B (p=0,016), houve diferença entre grupos A e C (p=0,049). Portanto, há diferença significativa entre grupos B e C em relação ao grupo A, ou seja, a acupuntura clássica e auricular diminuem a náusea entre oitavo e vigésimo primeiro dias em relação ao grupo controle. Conclusão: A acupuntura clássica diminui a intensidade e duração de náusea e vômito do primeiro ao sétimo dia pós-quimioterapia. A acupuntura clássica e auricular diminuem a intensidade de náusea do oitavo ao vigésimo primeiro dia pós-quimioterapia.The purpose of this study is to evaluate the efficacy of two acupuncture techniques in the control of the nausea and vomiting in patients diagnosed of Invasive Breast Carcinoma submitted to chemotherapy. Sixty four patients with pathological diagnosis of Invasive Breast Carcinoma were included in the study during the period of March 2003 to February 2007 at Hospital A.C. Camargo. The patients received adjuvant chemotherapy including doxorubicin and ciclophosphamide. The study was developed during the first chemotherapy cycle. The patients were randomized in 3 groups: Patients of the group A received conventional antiemetic treatment with drug administration. Patients of the group B received conventional antiemetic treatment with drug administration and application of classic acupuncture. Patients of the group C received conventional antiemetic treatment with drug administration and application of auricular acupuncture. During the first 21 days, the patients performed self-reports after receiving the chemotherapy shot, according to the Common toxicity criteria of the National Cancer Institute (NCI CTC). They filled out the data collection instrument related to the nausea and vomiting in this period. As for the nausea from the first to the seventh day, we found statistical significancy (p=0.040) using the Kruskal - Wallis test, suggesting that acupuncture reduces the intensity of nausea in this period. Regarding length of days having worse intensity of nausea in this period, results were statistically significant by ANOVA test (p=0.037) with acupuncture decreasing the number of days of worse intensity. Through the Mann Whitney test, we also found significant difference regarding the intensity of nausea among the groups A and B (p=0.013), showing that classic acupuncture reduces the intensity of nausea when compared to the control group. In relation to the days of worse intensity of nausea we found difference among the groups A and B (p=0.043) and among groups B and C (p=0.010) meaning that classic acupuncture decreases the days of worse intensity of nausea when compared to control group and auricular acupuncture group. As for the severity of the vomit, from the first to the seventh day, we found through Kruskal - Wallis test a significant difference (p=0.036) among the groups, suggesting that acupuncture reduces the severity of the vomits. Using the Mann - Whitney test among the groups A and B a significant difference was found (p=0.017) meaning that classic acupuncture reduces the severity of vomits compared to the control group. As for the number of days of vomit in worse degree between the first and the seventh day, we used the ANOVA test and found significant difference among the groups (p=0.029) with acupuncture reducing the number of days with vomit. The t test applied for the groups in pairs revealed statistical significance among groups A and B (p=0.035) and therefore, classic acupuncture reduces the number of days of vomit compared to the control group. We have analysed the intensity of nausea between eighth and twentieth first day. Through the Kruskal - Wallis test, we found significant difference among the groups (p=0.022) showing that acupuncture also reduces the nausea between eighth and twentieth first day. Analyzing the groups in pairs with the Mann - Whitney test, we found significant difference among the groups A and B (p=0.016) and among groups A and C (p=0.049). Therefore, there is significant difference among groups B and C in relation to the group A. Classic acupuncture and auricular acupuncture reduce the nausea between eighth and twentieth first days when compared to control group. Conclusion: Classic acupuncture reduces the intensity and duration of nausea and vomit from the first to the seventh day after chemotherapy. Classic acupuncture and auricular acupuncture reduce the intensity of nausea from the eighth to the twentieth first day after chemotherapy.
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Areff, Shamiel. "Metoclopramide vs Prochlorperazine for the treatment of Nausea and Vomiting in the Emergency Care Setting: A Scoping Review." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31473.
Повний текст джерелаАнотація:
Introduction: Nausea and vomiting are a common complaint with a wide variety of aetiologies. Patients frequently present to emergency care providers seeking treatment for nausea and vomiting. Metoclopramide and prochlorperazine are well established drugs that have long been used in the treatment of nausea and vomiting. This scoping review aims to map out the available literature on metoclopramide and prochlorperazine in treating nausea and vomiting in the emergency setting, and more specifically for prehospital use. Methods: A broad literature search was conducted using the following search terms “nausea”, “vomiting”, “emergency care setting”, “prehospital”, “motion sickness”, “emergency medical services”, “metoclopramide”, “prochlorperazine”, was done on online databases such as Pubmed, Medline, Embase Cochrane databases, CINAHL, Web of Science, TRIP and EBSCO host. Results: A total of 11 articles were found published between 1989 and 2014. Ten studies were found from emergency centres and just one from the prehospital setting. Six studies originated in America, three in Australia, one in the United Kingdom, and one in New Zealand. The total number of patients in the 11 included studies were 1319 subjects, where 511 received metoclopramide, 448 received a placebo, and 98 patients received prochlorperazine. One study found prochlorperazine to be the better antiemetic at treating nausea and vomiting, one study found metoclopramide to be better, and three studies found that the prophylactic use of metoclopramide cannot be justified. Conclusion: There is no consensus on the superiority of metoclopramide or prochlorperazine to treat uncomplicated nausea and vomiting in the emergency care setting. There is a paucity of research available and further studies needs to be done, particularly in the prehospital arena.
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Frazer, Carol-Anne. "An investigation of the pharmacological and non-pharmacological management of postoperative nausea and vomiting induced by patient controlled analgesia." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314034.
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Lawson, Christina Carole. "A PROSPECTIV STUDY OF COFFEE CONSUMPTION, NAUSEA, AND HORMONE LEVELS OF EARLY PREGNANCY." University of Cincinnati / OhioLINK, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ucin960902056.
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McKenna, D. J. J. "An investigation into the incidence and causes of dyspepsia and vomiting in pregnancy." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403244.
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Alkaissi, Aidah. "Postoperative Symptoms After Gynaecological Surgery : How They Are Influenced by Prophylactic Antiemetics Sensory Stimulation (P6-Acupressure)." Doctoral thesis, Linköpings universitet, Anestesiologi med intensivvård, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5196.
Повний текст джерелаАнотація:
Symptoms after surgery and anaesthesia influence the patient´s ability to resume daily activities. If postoperative symptoms are controlled rehabilitation may be accelerated. The aims of this dissertation were to identify disturbing symptoms reported by patients after gynaecological surgery, to investigate what effect prohylactic treatment with antiemetics has on these symptoms and whether or not sensory simulation of the P6-acupressure has an effect on postoperative nausea and vomiting (PONV) and motion sickness. Methods: Total 1138 women participated in three clinical trials (Studies I, II, III) and one experimental study (Study IV). A questionnaire investigating postoperative symptoms was constructed and validated. The questionnaire was used in a prospective, consecutive, doubleblind, randomised, multicentre, and controlled study to identify incidence, and intensity of postoperative symptoms and the effect of common antiemetics (droperidol and granisetron) (Study III). The patients were followed for 24 h. In two studies (I, II) P6-acupressure was compared (prospective, double-blind, ransomised, controlled) with placebo acupressure and a reference group where the effect on PONV was followed over 24 h. The effect of P6-acupressure and placebo acupressure on motion sickness induced by a nauseogenic motion challenge was studied (Study III). Results: A high incidence and severity of postoperative symptoms were found after gynaecological surgery in a group with a high risk (>30%) for PONV. Sixty-four per cent (107/165) of the patients experienced disturbing symptoms after surgery and 46 % (76/165) scored their symptoms as moderate to very severe. Fourty-eight per cent (79/165) had two or more symptoms. A higher incidence of symptoms were reported in the groups with prophylactic treatment, granisetron 74% (123/165) and droperidol 80% (133/165) compared to the control group 41% (69/165) (P <0.05). The relative risk reduction for PONV with granisetron or droperidol prophylaxis is 27% respective 22%. The relative risk increase for headache is 63% after granisetron, and 44% for difficulty with accommodation after droperidol. Less PONV was seen after P6-acupressure, 33% (44/135) compared to reference group 46% (63/136) (p = 0.019), number needed to treat (NNT) was 7 [95% confidence interval (CI) 4- 6]. When comparing laparoscopic and vaginal surgery (subgroup analysis) the main effect was in the vaginal group (day-case surgery), 36% (27/75) in the reference group to 27% (23/86) in the placebo group and to 20% (17/84) in the P6-acupressure group, (P = 0.017), NNT for the vaginal group was 6 [95% CI 3-18]. P6-acupressure increased time to nausea after a laboratory motion challenge and reduced the total number of symptoms reported (p <0.009). Conclusions: There is no clinical efficacy in the form of reduced postoperative symptoms after prophylactic antiemetics (droperidol and granisetron) in females with a high risk (>30%) for PONV undergoing gynaecological surgery. P6-acupressure reduces the incidence of PONV after gynaecological surgery in females with a high (>30%) risk for PONV. The effect seems to be most prominent after vaginal surgery. P6-acupressure increased tolerance to experimental nausogenic stimuli and reduced the total number of symptoms reported in females with a history of motion sickness.On the day of the public defence the status of article IV was: Submitted.
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Sticht, Martin. "The MAGL Inhibitor, JZL184, Attenuates LiCl-Induced Vomiting in the Suncus murinus and 2AG Attenuates LiCl-Induced Nausea-Like Behavior in Rats." British Journal of Pharmacology, 2009. http://hdl.handle.net/10214/2968.
Повний текст джерелаАнотація:
The role of 2-arachidonoylglycerol (2-AG) in nausea and vomiting was evaluated using a shrew (Suncus murinus) model of emesis and nausea-like behavior in rats, conditioned gaping. Shrews received JZL184, a selective MAGL inhibitor, prior to treatment with emetogenic lithium chloride (LiCl). The potential of exogenously administered 2-AG and arachidonic acid (AA) to regulate conditioned gaping was assessed in rats. The role of cannabinoid receptors and cyclooxygenase (COX) inhibition in suppression of vomiting and conditioned gaping was also evaluated. JZL184 dose-dependently suppressed vomiting in shrews, and was shown to inhibit MAGL in shrew brain tissue. The anti-emetic effects of JZL184 were prevented by the CB1 antagonist, AM251. Exogenous 2-AG suppressed LiCl-induced conditioned gaping, but was not prevented by AM251 or the CB2 antagonist, AM630. Instead, the COX inhibitor, indomethacin, prevented the suppressive effects of 2-AG, as well as AA. These results suggest that manipulations that elevate 2-AG may have anti-emetic/anti-nausea potential.This research was supported by research grants from the Natural Sciences and Engineering Research Council of Canada (NSERC 92057) to Linda Parker, the Israel Science Foundation (DA009789) to Raphael Mechoulam, and the National Institutes of Health (DA009789, DA017259) to Benjamin Cravatt.
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Juujärvi, Esteri, and Anna Strindberg. "Omvårdnadsåtgärder vid cytostatikarelaterade biverkningar : En systematisk litteraturstudie." Thesis, Högskolan Dalarna, Omvårdnad, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:du-3719.
Повний текст джерелаАнотація:
Syftet med denna litteraturstudie var att beskriva sjuksköterskans omvårdnadsåtgärder gentemot patienter med cancer vid cytostatikarelaterat håravfall, fatigue, illamående och kräkning. De vetenskapliga artiklar som användes för denna litteraturstudie hämtades ur Högskolan Dalarnas databaser Elin@Dalarna och PubMed. Efter kvalitetsgranskning och betygsättning av artiklarna kvarstod 18 artiklar som ansågs relevanta och låg till grund för resultatet av denna studie. Samtliga artiklar bedömdes ha en god vetenskaplig kvalitet. Resultatet av denna litteraturstudie visade att behandling mot håravfall med kylmössa hade god effekt men att biverkningarna kunde vara svåra att uthärda. Information från sjuksköterskan om sminkningsteknik och användning av peruk, upplevdes av patenten vara viktig vid håravfall. Regelbunden träning och avslappningsövningar hade en positiv effekt på fatigue. Sjuksköterskans information till patienter om fatigue och egenvårdsåtgärder, visade sig också vara till hjälp för patienterna. Vidare lindrade akupressur besvären vid illamående och kräkning. Sjuksköterskornas regelbundna kontroller av cytostatikarelaterade biverkningar förbättrade omvårdnadens kvalitet
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Hamada, Shota. "Antiemetic efficacy and safety of a combination of palonosetron, aprepitant, and dexamethasone in patients with testicular germ cell tumor receiving 5-day cisplatin-based combination chemotherapy." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/192148.
Повний текст джерелаАнотація:
Published in Supportive Care in Cancer 2014;22(8):2161-6. DOI:10.1007/s00520-014-2182-7Kyoto University (京都大学)
0048
新制・課程博士
博士(社会健康医学)
甲第18548号
社医博第59号
新制||社医||8(附属図書館)
31448
京都大学大学院医学研究科社会健康医学系専攻
(主査)教授 武藤 学, 教授 佐藤 俊哉, 教授 千葉 勉
学位規則第4条第1項該当
46
Gnatzy, Richard. "Auswirkungen der intraoperativen Gabe von Dexamethason zur PONV-Prophylaxe auf den Blutzucker- und Cortisolspiegel bei normalgewichtigen und adipösen Kindern." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-172595.
Повний текст джерелаАнотація:
Background: The incidence of postoperative nausea and vomiting (PONV) can be reduced by dexamethasone. Single dose administration may cause elevated blood glucose levels in obese adults. No data are available for children.
Objective: The aim was to evaluate perioperative blood glucose changes related to body weight in children who received dexamethasone.
Methods: This prospective observational study included 62 children. All patients received total intravenous anesthesia and a single dose of dexamethasone (0.15mg/kg, maximum 8mg). Blood glucose levels were measured up to 6 hours. Standard deviation scores (SDS) were calculated using age- and gender-specific BMI percentiles, p<0.05.
Results: 62 children (11.5±2.9years, median SDS 0.43, 29% overweight/obese) were included. Blood glucose level increased from 5.52±0.52 to 6.74±0.84mmol/l 6h after dexamethasone without correlation to the BMI-SDS.
Conclusions: This study shows an increase of perioperative blood glucose (normoglycemic ranges) after single dose of dexamethasone but no BMI-dependent effect in children. Therefore, low-dose dexamethasone may be used in obese children for PONV prophylaxis.
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Dent, Heather Elizabeth. "Development of a research base and management protocol for the use of nurses caring for patients with nausea and vomiting following acute myocardial infarction." Thesis, University of Exeter, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287999.
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Smyła, Natalia [Verfasser], and Leopold [Akademischer Betreuer] Eberhart. "Amisulpride: Efficacy and Adverse Events in the Management of Postoperative Nausea and Vomiting — a Systematic Review and Quantitative Meta-analysis / Natalia Smyła ; Betreuer: Leopold Eberhart." Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1224046773/34.
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Borglin, Lina, and Sofia Westerlund. "Sjuksköterskans omvårdnadsåtgärder vid postoperativt illamående." Thesis, Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-14362.
Повний текст джерелаАнотація:
Postoperativt illamående och kräkning (PONV- Postoperative Nausea and Vomiting) är en vanlig förekommande kirurgisk komplikation. Orsaken till PONV är inte helt fastställd, till skillnad från patofysiologin vid generellt illamående. För patienten innebär PONV ett ökat lidande och längre vistelse på sjukhus. För att förebygga och lindra tillståndet PONV kan sjuksköterskan identifiera riskfaktorer hos patienten. Kirurgiska ingrepp har visats ge olika grader av illamående. Exempelvis innebär laparaskopi en ökad risk för PONV. Betydelsefullt är att sjuksköterskan har kunskap och kan identifiera, samt uppmärksamma, tidiga tecken hos patienten. Dessa tecken kan vara blekhet, kallsvettighet eller en ökad hjärtfrekvens. Syftet med litteraturstudien var att belysa sjuksköterskans omvårdnadsåtgärder vid postoperativt illamående och kräkning. Litteraturstudiens resultat baserades på 12 vetenskapliga artiklar. Resultatet visade att kombinationen av antiemetika och icke farmakologiska åtgärder ger en viss lindring av PONV. Det vore önskvärt att upptäcka omvårdnadsåtgärder som minskar incidensen av PONV eftersom en stor andel av sjukvården utgörs av kirurgiska patienter. Sjuksköterskans omvårdnadsåtgärder klargörs inte helt och borde tydliggöras genom mer forskning inom området.Postoperative nausea and vomiting (PONV) is a common surgical complication. The cause of PONV is not precisely clear, in contrast to the pathophysiology of general nausea. Consequences of PONV include increased care suffering and longer duration in hospital care. To prevent or relieve PONV, nurses can identify risk factors. Surgical procedures have been shown to have various degrees of nausea, such as laparoscopy have an increased risk for PONV. It is significant that the nurse has knowledge about the relevant symptoms and can identify early signs of the patient. The aim of this study was to illuminate nursing interventions to prevent postoperative nausea and vomiting. The results of this literature study were based on 12 scientific articles. The results showed that the combination of antiemetic and non-pharmacological measures gave some relief of PONV. Desirable would be to identify nursing interventions that could decreased the incidence of postoperative nausea and vomiting of the surgical patients as they constitute a large proportion of patients within the health care. Recommended nursing strategies are not entirely clear and need to be clarified through further research on this topic, nursing care intervention.
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Campos, Guilherme Oliveira. "Ensaio clínico randomizado comparando palonosetrona com ondansetrona para profilaxia de náuseas e vômitos após histerectomia abdominal sob raquianestesia com morfina." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152451.
Повний текст джерелаАнотація:
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Introdução: histerectomia abdominal é cirurgia amplamente realizada no mundo, e raquianestesia com adição de morfina é considerada a técnica anestésica de escolha devido a melhor qualidade de recuperação e adequado controle da dor pós-operatória. No entanto, náuseas e vômitos pós-operatórios (NVPO) são problemas frequentes quando morfina é utilizada no neuroeixo. Palonosetrona é um antagonista serotoninérgico potente e com longa duração de ação, efetivo na prevenção de NVPO após anestesia geral. O seu efeito após anestesia no neuroeixo ainda não foi estabelecido. Nós comparamos palonosetrona com ondansetrona para profilaxia de NVPO quando raquianestesia com morfina foi usada em pacientes com alto risco para NVPO. A hipótese é que a palonosetrona promove melhor controle de NVPO quando comparada com ondansetrona nesse contexto. Métodos: após aprovação do Comitê de Ética em Pesquisa, foram incluídas no estudo 140 pacientes elegíveis para histerectomia abdominal sob raquianestesia com adição de morfina. Todas receberam anestesia subaracnóidea com administração de 15 mg de bupivacaína hiperbárica e 0,1 mg de morfina. Dexametasona 8 mg foi administrada por via endovenosa em todas as pacientes como uma abordagem multimodal para prevenção de NVPO. As pacientes foram divididas aleatoriamente em dois grupos para receber 0,075 mg de palonosetrona ou 4 mg de ondansetrona antes do início da cirurgia. O desfecho primário avaliado foi a incidência global de NVPO nas 48h após a cirurgia. Adicionalmente, náuseas e vômitos foram analisados separadamente, e classificados como eventos precoces (≤ 6h) ou tardios (> 6h). Questionários foram aplicados para determinar a ocorrência de NVPO clinicamente importante, e satisfação geral. Resultados: a incidência global de NVPO foi de 42,9% no grupo palonosetrona e 52,9% no grupo ondansetrona (p = 0,23). Não houve diferença estatisticamente significante na incidência de náusea precoce (21,4% vs 27,1%, p = 0,43), náusea tardia (30% vs 35,7%, p = 0,47), ou vômito precoce (14,3% vs 20%, p = 0,37) entre os dois grupos. A ocorrência de vômitos tardios foi significativamente menor no grupo palonosetrona (11,4% vs 27,1%, p = 0,018). NVPO clinicamente importante teve uma baixa incidência nos dois grupos (2,8% vs 5,7%, p > 0.05), e não houve diferença na satisfação dos pacientes. Conclusão: palonosetrona não reduz a incidência global de NVPO em comparação com ondansetrona, mas reduz a incidência de vômitos tardios após histerectomia abdominal sob raquianestesia e morfina subaracnóidea.