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Дисертації з теми "Nicotinic acetylcholine receptors α7"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Hammond, Victoria. "α7 nicotinic acetylcholine receptors at the glutamatergic synapse". Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633163.

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Nicotinic acetylcholine receptor (nAChR) activation is neuroprotective and nicotine is a cognitive enhancer. Loss of nAChRs, deposition of tau neurofibrillary tangles, cleavage of amyloid precursor protein (APP) and inflammation are well documented in the pathogenesis of Alzheimer’s disease (AD). Sequential cleavage of APP by β- and γ-secretase enzymes generates soluble Aβ peptides, with oligomeric forms of Aβ implicated in both the control of synaptic excitability and dysregulation of synaptic transmission and induction of neuronal death in AD. Aβ production is inhibited by calcium-dependent

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2

Van, Rensburg Ruan. "Upregulation of neuronal α7 nicotinic acetylcholine receptors and preconditioning". Thesis, Durham University, 2007. http://etheses.dur.ac.uk/2452/.

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The upregulation of alpha 7 nicotinic acetylcholine receptors (α7 nAChRs) are putatively reported to play a role in in vivo cortical spreading depression-elicited neuroprotection. In this study, a reliable in vitro spreading depression model was created for studying this phenomenon. In contradiction to previous studies, it was, however, shown that functional α 7 nAChRs are down-regulated upon chronic depolarisation with KCl, although the activity of this receptor subtype remained essential for the preconditioning mechanism. Evidence was provided for a differential mechanism underlying protecti

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3

Brown, Jack. "α7 Nicotinic acetylcholine receptor-mediated calcium signalling in neuronal cells". Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636524.

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α7 nicotinic acetylcholine receptors (nAChR) are highly permeable to Ca2+ and are clinical targets for Alzheimer’s disease and schizophrenia. The aim of this work was to examine α7 nAChR-mediated Ca2+ signalling in neuronal cells using three different methods, and to evaluate the effects of the desensitizing agonist and prototypical smoking-cessation drug sazetidine-A on α7 nAChRs. Initial studies used 96-well plate assays with SH-SY5Y cells to characterize responses evoked by the α7 nAChR-selective agonist PNU-282987 and positive allosteric modulator PNU-120596. This was complemented by live-

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4

Jackson, Asti. "Investigating the Modulation and Mechanisms of α7 Nicotinic Acetylcholine Receptors in Nicotine Dependence". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4851.

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Tobacco dependence dramatically increases health burdens and financial costs. Limitations of current smoking cessation therapies indicate the need for improved molecular targets. Nicotine, the main addictive component of tobacco, exerts its dependency effects via nicotinic acetylcholine receptors (nAChRs). The homomeric α7 nAChR is one of the most abundant receptors found in the brain and has unique features in comparison to other nAChR subtypes such as high calcium permeability, low probability of channel opening, and a rapid desensitization rate. α7 nAChR agonists reduce nicotine's rewarding

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5

Udakis, Matthew. "α7 nicotinic acetylcholine receptors : regulation of plasticity and network activity in the prelimbic cortex". Thesis, University of Bath, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707589.

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Abnormalities in the connectivity and activity of the prefrontal cortex (PFC) is the cause of many of the symptoms of neuropsychiatric disorders such as schizophrenia and Alzheimer’s disease. The PFC relies on a complex regulation of network activity and synaptic plasticity for healthy PFC function. These fundamental processes can be modulated by the neuromodulator acetylcholine, acting at α7 nicotinic acetylcholine receptors (α7 nAChRs), a system also compromised in neuropsychiatric disorders. Despite the evidence that α7 nAChRs are essential for healthy PFC function relatively little is know

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6

Anderson, Malia L. "The Effects of β-Amyloid on α7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes". BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2966.

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The exact mechanism and progression of Alzheimer's disease (AD) at present is not fully understood. In patients suffering from AD, damage to the hippocampal region and impairment of learning and memory is present. It is also known that a buildup of β-amyloid plaques occur in AD patients and that β-amyloid interacts with some subtypes of neuronal nicotinic acetylcholine receptors (neuronal nAChRs). These receptors are composed of five subunits. The most prevalent nAChR subunit composition through the brain as a whole is α7. Previous data produced from our lab suggests that α7 nAChRs are also on

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7

Young, Jared W. "Nicotine induced improvements in cognition : a possible role for the α7 nicotinic acetylcholine receptor". Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/27731.

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Assessment of sustained attention in rodents can be performed using the 5-choice serial reaction-time (5-CSR) task; analogous to the continuous performance test used in man. A 5-CSR protocol was established which allowed the demonstration of nicotine-induced improvements in sustained attention in mice. In this task α7 nAChR knockout (KO) mice exhibited impaired acquisition and performance, providing additional evidence that this receptor may be a valid therapeutic target for cognitive enhancement. In order to investigate the role of nAChR manipulation on working memory, the odour span task, a

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8

Nishio, Takahiro. "Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis". Kyoto University, 2017. http://hdl.handle.net/2433/225984.

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9

Beinat, Corinne. "The design and synthesis of selective α7 nicotinic acetylcholine receptor agonists for the treatment of neurological disease". Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11635.

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Анотація:

The homomeric α7 nAChR is a ligand gated ion channel found throughout the CNS and PNS and is one of the most commonly expressed nicotinic receptors in the human brain. The α7 nAChR is expressed in particularly high levels in brain regions associated with learning and memory, such as the cerebral cortex and the hippocampus. Experimental evidence supports the involvement of this receptor in schizophrenia and Alzheimer’s disease (AD), modulators of the α7 nAChR have been extensively reviewed for the treatment of the cognitive deficits associated with these pathologies. Multiple α7 nAChR agonists

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10

Davy, Robert Carlos Barton. "Development of a transient expression system for the α7 neuronal nicotinic acetylcholine receptor in mammalian cells". Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295445.

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11

Alwassil, Osama I. "Elaboration and Design of α7 nAChR Negative Allosteric Modulators". VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3902.

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α7 Neuronal nicotinic acetylcholine receptors are one of two major classes of receptors responsible for cholinergic neurotransmission in the central nervous system. The existence of α7 neuronal nAChRs in different regions of the nervous system suggests their involvement in certain essential physiological functions as well as in disorders such as Alzheimer’s disease (AD), drug dependence, and depression. This project was aimed toward the discovery and development of small–molecule arylguanidines that modulate α7 nAChR function with improved subtype-selectivity through an allosteric approach. Id

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12

Tornoe, Calilla. "Nicotinic acetylcholine receptors in nematodes." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363452.

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13

El-Hajj, Raed A. "Pharmacological and immunological identification of native α7 nicotinic receptors: evidence for homomeric and heteromeric α7 receptors". The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1198155366.

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14

Pagan, Augustine J. IV. "Heterosandwich assay of nicotinic acetylcholine receptors." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3815.

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Анотація:

Using the technology afforded by Winschel et al., cyclen-1, a high affinity, strong complexation agent for 8-hydroxypyrene-1,3,6 trisulfonate and derivatives, a new assay has been developed for fluorescently labeling proteins of interest (POIs). Ligation of the endogenous ligand for nicotinic acetylcholine receptors (nAChRs), acetylcholine, using click chemistry afforded the triazole derivative of an alkynyl-acylcholine (compound 1) with 8-azidopyrene-1,3,6 trisulfonate (compound 2). Liposomes encapsulated with Rhodamine B were used to strengthen the initial fluorophore response of compound 2,

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15

Komourian, Jacques. "Alpha-bungarotoxin sensitive neuronal nicotinic acetylcholine receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29731.pdf.

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16

Walsh, Susan. "Search for nicotinic acetylcholine receptors on lymphocytes." Thesis, University of Bath, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760593.

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17

Demmerly, Arianna L. "Mechanisms of modulation of nicotinic acetylcholine receptors." Thesis, University of Alaska Fairbanks, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10244902.

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<p> Inappropriate expression of nicotinic acetylcholine receptors in the central nervous system is associated with nicotine addiction, Alzheimer’s disease, Parkinson’s disease and other disorders. Modulators (drugs) have the potential to restore circuit properties that arise from inappropriate expression of nicotinic receptor’s. Compounds that interact with allosteric sites have a distinct advantage over agonists and partial agonists, in that, they retain normal activation patterns by allowing binding of the endogenous ligand. Positive allosteric modulators boost the receptor

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18

Chatzidaki, A. "Pharmacological characterisation of neuronal nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1473233/.

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Nicotinic acetylcholine receptors (nAChRs) are the targets for the endogenous neurotransmitter acetylcholine and represent a diverse family of ligand-gated ion channels. They are expressed in the neuromuscular junction, the peripheral nervous system and the central nervous system. In the brain, the most prevalent subtypes are the heteromeric α4β2 and homomeric α7 nAChRs. Neuronal nAChRs are implicated in numerous physiological and pathophysiological functions and are therefore important targets for therapeutic drug discovery for conditions such as Alzheimer’s disease, schizophrenia and tobacco

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19

Rapier, Catherine Margaret. "Characterisation of mammalian central nicotinic acetylcholine receptors." Thesis, University of Bath, 1986. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374614.

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20

Crawford, Nicola. "Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂". Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29079.

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Radioligand binding was used to characterise the α<sub>4</sub>β<sub>2</sub> nAChR ([<sup>3</sup>H]-epibatidine and [<sup>3</sup>H]-cytisine) and α<sub>7</sub> nAChR ([<sup>3</sup>H]-methyllycaconitine ([<sup>3</sup>H]-MLA) and [<sup>3</sup>H]-αBungarotoxin ([<sup>3</sup>H]-αBgTx)) in rat and mouse brain tissue and in SH-EP1 cell lines overexpressing human forms of the α<sub>4</sub>β<sub>2</sub> or α<sub>7</sub> nAChRs. No species difference in ligand affinities were observed for the α<sub>4</sub>β<sub>2</sub> nAChR. In contrast, nicotinic agonists exhibited significantly higher affinity (~100

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21

Afar, Ronith. "Regulation and function of neuronal nicotinic acetylcholine receptors." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41288.

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Two major subtypes of nicotinic acetylcholine receptors (nAChRs) have been identified in the nervous system. One site is bound by $ alpha$-bungarotoxin ($ alpha$-BGT), while the other has a higher affinity for agonists and does not bind the $ alpha$-toxin. Muscle nAChRs, which also bind $ alpha$-BGT, had been reported to be sensitive to a thymus-derived polypeptide, thymopoietin (TPO). The present work was therefore done to determine whether this agent might also interact with the different nAChR populations in neuronal cells.<br>Initial studies involved thymopentin (TP-5), a 5 amino-acid pept

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22

Lansdell, Stuart John. "Folding and assembly of neuronal nicotinic acetylcholine receptors." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298829.

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23

Collins, T. "Molecular pharmacological characterisation of neuronal nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/624494/.

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Анотація:

Neuronal nicotinic acetylcholine receptors (nAChRs) are excitatory ligand‐gated ion channels that perform important roles throughout the nervous systems of both vertebrate and invertebrate organisms. Impairments to human nAChRs and cholinergic transmission are thought to underlie the pathophysiologies of several neurological and psychological diseases including schizophrenia, Alzheimer’s disease, Parkinson’s disease and certain forms of epilepsy. They are also the receptors that mediate the effects of tobacco smoking and contribute to the physiological and psychological changes associated with

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24

AlSharari, Shakir. "Role of Nicotinic Acetylcholine Receptors in Experimental Colitis." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2895.

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Анотація:

Substantial evidence in the literature shows that tobacco smoking has complex and divergent effects on inflammatory bowel diseases (IBD). It ameliorates ulcerative colitis (UC); whereas it aggravates the risk of Crohn’s disease (CD) and affects the disease course and severity. Studies have shown that nicotine has a positive influence on symptoms of UC. Also, it is demonstrated that nicotinic acetylcholine receptor, especially α7 subunit plays an essential component in the vagus nerve-based cholinergic anti-inflammatory effects. In the present study, we explored the effect of nicotine and α7 ni

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25

Gill, J. K. "Allosteric modulation of alpha 7 nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1415907/.

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Nicotinic acetylcholine receptors (nAChRs) are selective ion channels that belong to the Cys-loop superfamily of ligand-gated ion channels. They are expressed in skeletal muscle, where they mediate muscle contraction, and in the peripheral nervous system, where they mediate ganglionic transmission. NAChRs are also widely expressed in the central nervous system, where they regulate the release of acetylcholine and several other important neurotransmitters. Conventional nAChR agonists, such as acetylcholine, act at an extracellular ‘orthosteric’ binding site, located at the interface between two

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26

Haghighi, Ali Pejmun. "Mechanism of inward rectification of neuronal nicotinic acetylcholine receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0032/NQ64568.pdf.

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27

Kirwan, Michael Joseph. "Molecular cloning and characterisation of insect nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408548.

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28

Purohit, Prasad G. "Molecular determinants of pharmacological distinctions among nicotinic acetylcholine receptors." Thesis, University of Strathclyde, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424352.

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29

Cross, Kathryn Mary Louise. "Studies on nicotinic acetylcholine receptors expressed in surrogate cells." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295914.

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30

Williamson, Sally. "Nicotinic acetylcholine receptors from the parasitic nematode Ascaris suum." Thesis, University of Bath, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501371.

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Nematodes of the genus Ascaris are large gastrointestinal parasites. Ascaris lumbricoides infects ~1 billion people globally; causing malnutrition and general morbidity, and can block the gut or bile duct causing fatal complications. Ascaris suum is a parasite of pigs; in addition to its veterinary significance, it can occasionally be zoonotic, and is a good model of the human parasite. One of the main classes of drugs used to treat parasitic nematode infections are the cholinergic anthelmintics, such as levamisole and pyrantel, which act as agonists of nicotinic acetylcholine receptors at the

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31

Wright, Victoria Louise. "The role of nicotinic acetylcholine receptors in motivated behaviour." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687374.

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Understanding how memory, learning and reward work in unison to form adaptive and sometime maladaptive behaviour is at the forefront of modern neuroscience. The largest unmet need in treating maladaptive reward learning behaviours such as addiction is maintaining long-term abstinence and preventing relapse after re-exposure to drug-associated cues. Nicotinic acetylcholine receptors (nAChR) have been implicated in responses to drugs of abuse other than nicotine (Rahman et al., 2015) and the aim of this work was to characterise the role of α7 nAChRs in morphine reward learning using conditioned

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32

Free, R. Benjamin. "Characterization and regulation of adrenal neuronal nicotinic acetylcholine receptors /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486402957198247.

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33

Gentry, Cynthia. "Effects of chronic ligand exposure on nicotinic acetylcholine receptors." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/289833.

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To illuminate effects of chronic nicotinic ligand treatment on nicotinic acetylcholine receptor (nAChR) function, responses to acute agonist challenge after nicotinic ligand pre-exposure were studied using ion efflux assays. Losses in function of heterologously-expressed, human α4β2- and α4β4-nAChR were observed following exposure to concentrations of nicotine at or below levels of nicotine present in the brain and serum of human smokers and showed both time- and concentration-dependence. α4β2- and α4β4-nAChR functional responsiveness to acute agonist challenge following prolonged exposure to

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34

Mandelzys, Allan. "Postnatal expression of nicotinic acetylcholine receptors by rat peripheral neurons." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39557.

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Synaptogenesis is a complex process involving several steps that ultimately results in the matching of neurotransmitters released from the presynaptic nerve terminals with the appropriate receptors expressed by the postsynaptic neuron. In this thesis, I examined one step in the process of synaptogenesis, the expression of postsynaptic receptors. Cultured neonatal rat nodose neurons are a good model for these studies; in vivo, nodose neurons do not form synaptic contacts, but interestingly, when they develop alone in dissociated tissue culture most neurons express nicotinic acetylcholine recept

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35

Thomas, Philip. "Structure-activity studies of ligands for brain nicotinic acetylcholine receptors." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760682.

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36

Baker, Elizabeth Rae. "Molecular and cell biological characterisation of neuronal nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446728/.

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Анотація:

Molecular and cell biological characterisation of neuronal nicotinic acetylcholine receptors (nAChRs) provides an insight into their functional roles and potential as therapeutic targets for neurological disorders. Nicotinic receptors are oligomeric ligand-gated ion channels, comprising five subunits. Twelve vertebrate neuronal nAChR subunits (2-10 and 2-4) have been cloned to date, with considerable diversity observed in nAChR subunit composition. Heterologous expression of cloned subunits is a powerful method for investigating ion channel receptor pharmacology and subunit composition, but ac

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37

Ackerman, Kristin M. "Zebrafish Neuronal Nicotinic Acetylcholine Receptors: Cloning, Expression, and Functional Analysis." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1230926368.

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38

Torrice, Michael McCann Dervan Peter B. Dougherty Dennis A. "Chemical-scale studies of the nicotinic and muscarinic acetylcholine receptors /." Diss., Pasadena, Calif. : California Institute of Technology, 2009. http://resolver.caltech.edu/CaltechETD:etd-08072008-103726.

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39

Ackerman, Kristin Michelle. "Zebrafish neuronal nicotinic acetylcholine receptors cloning, expression, and functional analysis /." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1230926368.

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40

Rust, Gabriele. "Neuronal nicotinic acetylcholine receptors in the rat automatic nervous system /." [S.l : s.n.], 1995. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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41

Bizimana, Ladislas. "Pharmacological Evaluation of Choline on α4β2 Neuronal Nicotinic Acetylcholine Receptors". Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14011.

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Choline is the precursor and metabolite of acetylcholine (ACh), the endogenous neurotransmitter responsible for activation of neuronal nicotinic acetylcholine receptors (nAChRs). Choline is known to activate some nAChRs, which suggests that it may play a role in neurotransmission beyond being a precursor/metabolite. Using electrophysiological techniques, this study investigates effects of choline on currently known α4β2 nAChRs stochiometries ― (α4)3(β2)2 and (α4)2(β2)3. The results suggests that choline activates (α4)3(β2)2 nAChRs with EC50 of 0.4mM and a maximal efficacy of 4%. In contrast, i

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42

Mohammadi, Sarasa Amilia. "The involvement of α9α10-nicotinic acetylcholine receptors in pain states". Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14181.

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The α9 subunit of nicotinic acetylcholine receptors (α9-nAChR) has recently attracted the interest of pain researchers, after the discovery of highly efficacious α9α10-nAChR-inhibiting analgesics. The α9α10-nAChR has since been pursued as a novel analgesic target. However, the evidence to implicate this receptor subunit in nociception and analgesia has been indirect and conflicted. Here, a direct approach to studying the role of the α9α10-nAChR in pain and other behavioural states was undertaken. Pain phenotyping in α9-nAChR knockout (KO) mice revealed a limited clinical potential for specifi

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43

Dajas-Bailador, Federico. "Cellular responses elicited by stimulation of neuronal nicotinic acetylcholine receptors." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392053.

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44

Slater, E. Yvonne. "The effects of novel alkaloid derivatives on human nicotinic acetylcholine receptors." Thesis, Oxford Brookes University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327680.

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45

Sgard, Frederic. "Molecular genetic studies on nicotinic acetylcholine receptors of major insect pests." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239499.

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46

Boorman, James Philip. "Neuronal nicotinic acetylcholine receptors : the role of the Î²3 subunit." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397314.

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47

Garland, Catherine Mary. "The action of non-depolarising muscle relaxants at nicotinic acetylcholine receptors." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242436.

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48

Moore, C. "The role of neuronal nicotinic acetylcholine receptors in central cardiovascular regulation." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444883/.

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Анотація:

The central effect of nicotine on cardiovascular regulation has been extensively studied. However, due to its unselective nature for nicotinic acetylcholine receptors (nAChR) the involvement of specific nAChRs at sites in the brain, in central nervous cardiovascular regulation remains unclear. The effects of intracerebroventricular (i.c.v.) and intracisternal (i.e.) injections of the a7 selective agonist, PSAB-OFP, and the a4p2 selective agonist, TC-2559, were investigated on blood pressure (BP), heart rate (HR) and renal sympathetic nerve activity (RSNA) compared with nicotine, in the anaesth

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49

Harrington, Lauriane. "The role of β4-containing nicotinic acetylcholine receptors in nicotine addiction". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066328/document.

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Le tabac est consommé par environ un milliard de personnes. D'après l'Organisation Mondiale de la Santé, le tabagisme est la première cause évitable de mortalité dans le monde, provocant six millions de morts par an. La nicotine est le composant neuro-actif principal dans le tabac, et exerce ses effets neurologiques via une activation directe des récepteurs nicotiniques de l’acétylcholine (nAChR). Ces récepteurs transmembranaires sont composés de sous-unités alpha, ou alpha plus beta, créant une variété de canaux ioniques ligand-dépendants activés par le neurotransmetteur ACh. Les études génét

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50

Jackson, Doris Clark. "Characterization of Neuronal Nicotinic Acetylcholine Receptors and their Positive Allosteric Modulators." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6856.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are necessary in memory and cognition. They are pentameric and consist of Î± and Î² subunits. They are most commonly heteromeric but, can sometimes be homomeric. nAChRs are activated by many ligands including nicotine (exogenous) and acetylcholine (endogenous).nAChRs are located on hippocampal interneurons. The interneurons, although sparse, control the synchronous firing of the pyramidal cells. However, the hippocampal interneuron structure and function is quite diverse and not fully characterized. Therefor

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