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Добірка наукової літератури з теми "Nitro-Imidazole derivative"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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Статті в журналах з теми "Nitro-Imidazole derivative"

Afandi, Trisno, Bambang Purwono, and Winarto Haryadi. "Effect of Nitro Group on Imidazole Derivative as Colorimetric Chemosensor for Amines." Key Engineering Materials 840 (April 2020): 385–91. http://dx.doi.org/10.4028/www.scientific.net/kem.840.385.

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Chemosensor of imidazole derivative (4-(4,5-diphenyl-1H-imidazol-2-yl)-2-methoxy-6-nitrophenol) (IMD-1) has been synthesized and tested for amines sensor. IMD-1 was synthesized from the reaction of 5-nitrovanillin, 1,2-diphenylethane-1,2-dione (benzil), and ammonium acetate using reflux method. IMD-1 showed fast respond and color change from light orange to orange in naked eye compared with the imidazole derivative without nitro group (IMD-0). The IMD-1 could detect butylamine quantitatively with detection limit of 1.03 x 10-4 M.

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Kubicki, Maciej, Teresa Borowiak, Grzegorz Dutkiewicz, Stanisław Sobiak, and Iwona Weidlich. "1,2-Dimethyl-4-nitro-5-morpholinoimidazole and its hydrate: a case of a centrosymmetric–noncentrosymmetric ambiguity." Acta Crystallographica Section B Structural Science 59, no. 4 (2003): 487–91. http://dx.doi.org/10.1107/s010876810301070x.

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The compound studied is 1,2-dimethyl-4-nitro-5-morpholinoimidazole (1) in its anhydrous (1) and hydrated [(1)·H2O] crystal forms. In spite of the strong electron-withdrawing effect of the nitro group, the unsubstituted N atom of the imidazole moiety retains its basic character and acts as an acceptor for intermolecular hydrogen bonds: either weak C—H...N bonds in (1) or strong O—H...N bonds, with the water molecules, in (1)·H2O. The packing in (1) is determined by weak C—H...N and C—H...O hydrogen bonds, van der Waals interactions and the stacking of imidazole fragments. The crystal structure

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Dr., Sonali Banpure* Bhalekar Pournima Ingale Pramod Matade Siddhesh Mhase Pratiksha. "Design, In Silico Evaluation, Synthesis and Biological Evaluation Of 4-Nitroimidazole Derivatives." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1621–27. https://doi.org/10.5281/zenodo.15381646.

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This study aimed to design and evaluate novel antitubercular agents using computational methods. Four derivatives of isoniazid and acyclovir were designed and subjected to molecular docking studies against the 3IX2 protein. The results showed that the first derivative had the lowest binding energy (-11.58) and formed three hydrogen bonds with the protein. ADMET analysis was performed to evaluate the pharmacokinetic properties of the designed compounds. Based on the molecular docking and ADMET analysis, the first derivative was identified as the most promising compound for further development a

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Kubicki, Maciej. "Two tautomers in one crystal: 4(5)-nitro-5(4)-methoxyimidazole." Acta Crystallographica Section B Structural Science 60, no. 2 (2004): 191–96. http://dx.doi.org/10.1107/s0108768104003179.

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The case of prototropic annular tautomerism in an imidazole derivative has been found. The crystal structure contains a 50:50 mixture of two tautomers: 4-nitro-5-methoxyimidazole and 5-nitro-4-methoxyimidazole. The X-ray experiment actually shows the superposition of these compounds; it appears as if the structure is centrosymmetric and the N—H hydrogen atoms are disordered over two ring N atoms. Owing to the hydrogen-bond pattern, the values of their site occupation factors have to be exactly equal to 1/2. The molecules are connected into a three-dimensional network by means of N—H...N and C—

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Al-Abboodi1, Doaa Hashim, and Naeemah Al-lami. "NEW METHDOLOGY OF SYNTHESIS PYRAZOLO- THIAZOLO DERIVATIVES WITH STUDY ANTIMICROBAL ACTIVITIES." iraqi journal of market research and consumer protection 16, no. 1 (2024): 1–12. http://dx.doi.org/10.28936/jmracpc16.1.2024.(1).

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In this contribution, new derivatives of thiosemicarbazon, cyclic thiazolidinone, yilidine thiazolidinone, and parazolo-thiazole were synthesized, starting from the reaction of 2 -aminobenzothiazole with p-bromo phenacyl bromide to give the first step of 2(4-bromo phenyl) imidazole (2,1 -b) benzo thiazole (1). Compound (1) then was subjected under Viels Myer Haack to yield 3-carbaldehyde linking with imidazo-benzothiazol (2). Compound (2) condensed with thiosemicarbazide togivenewsynthesis of thiosemicarbazon derivative (3). Compound 4-Oxo-1,3-thiazolidine (4) was constituted from reacting com

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Heras Martinez, Hector Mario, David Chavez Flores, Patrick C. Hillesheim, Siddappa Patil, and Alejandro Bugarin. "Crystal structure and spectroscopic properties of (E)-1,3-dimethyl-2-[3-(4-nitrophenyl)triaz-2-enylidene]-2,3-dihydro-1H-imidazole." Acta Crystallographica Section E Crystallographic Communications 77, no. 2 (2021): 130–33. http://dx.doi.org/10.1107/s2056989021000426.

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The title compound (E)-1,3-dimethyl-2-[3-(4-nitrophenyl)triaz-2-enylidene]-2,3-dihydro-1H-imidazole, C11H12N6O2, has monoclinic (C2/c) symmetry at 100 K. This triazene derivative was synthesized by the coupling reaction of 1,3-dimethylimidazolium iodide with 1-azido-4-nitro benzene in the presence of sodium hydride (60% in mineral oil) and characterized by 1H NMR, 13C NMR, IR, mass spectrometry, and single-crystal X-ray diffraction. The molecule consists of six-membered and five-membered rings, which are connected by a triazene moiety (–N=N—N–). In the solid-state, the molecule is found to be

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Mohamed, Shaaban K., Jim Simpson, Adel A. Marzouk, et al. "Multicomponent green synthesis, spectroscopic and structural investigation of multi-substituted imidazoles. Part 1." Zeitschrift für Naturforschung B 70, no. 11 (2015): 809–17. http://dx.doi.org/10.1515/znb-2015-0067.

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AbstractTen 1,2,4,5-tetra-substituted imidazole derivatives have been synthesized with a 2-hydroxyethy substituent at the 1-nitrogen atom and potentially electron releasing hydroxy-, methoxy-, dimethylamino- or nitro substituents in various positions on the benzene ring located on the 2-carbon atom. The prototypical derivative with an unsubstituted phenyl ring at the 2-position is also reported. The compounds are obtained in excellent yields (average 86%) via a four-component cyclocondensation reaction of benzil, ethanolamine, and the appropriate aromatic carbaldehyde together with ammonium ac

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Huang, Xi-Shou, Li-Sheng Wang, Yong Yin, et al. "Synthesis, Characterization and Bioactivity Research of a Derivative of Secnidazole: 1-(2-Chloropropyl)-2-methyl-5-nitro-1H-imidazole." Journal of Chemical Crystallography 41, no. 9 (2011): 1360–64. http://dx.doi.org/10.1007/s10870-011-0104-9.

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Amini, S. K., N. L. Hadipour, and F. Elmi. "A study of hydrogen bond of imidazole and its 4-nitro derivative by ab initio and DFT calculated NQR parameters." Chemical Physics Letters 391, no. 1-3 (2004): 95–100. http://dx.doi.org/10.1016/j.cplett.2004.04.065.

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Pawar, Harshal Ashok, and Pooja Rasiklal Joshi. "Development and Evaluation of Taste Masked Granular Formulation of Satranidazole by Melt Granulation Technique." Journal of Pharmaceutics 2014 (February 12, 2014): 1–7. http://dx.doi.org/10.1155/2014/789676.

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Drugs from nitroimidazole category are generally bitter in taste. Oral formulation with bitter taste is not palatable. Geriatrics and pediatrics patients usually suffer from swallowing difficulties. Many other patients in some disease conditions avoid swallowing tablets. Satranidazole is a new nitro-imidazole derivative with bitter taste and is available in market as film coated tablet. The purpose of this research was to mask the bitter taste of Satranidazole by coating complexation with low melting point wax and Eudragit EPO. Different types of wax (glyceryl monostearate, stearic acid and ce

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Більше джерел

Дисертації з теми "Nitro-Imidazole derivative"

Albuquerque, Cristina Northfleet de. "Synthèses et études physico-chimiques d'analogues du MEGAZOL, anti-parasitaire du type nitro-imidazole : étude de leur mode d'action." Toulouse 3, 1995. http://www.theses.fr/1995TOU30039.

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Le travail presente relevant d'une collaboration entre plusieurs equipes bresiliennes et celles de l'ups, porte sur l'etude de derives nitro-imidazoles susceptibles d'interagir par voie radicalaire pour produire diverses especes oxygenees. Ces composes sont utilises comme modeles pour definir les caracteristiques de nouvelles generations de molecules pouvant agir sur le metabolisme de l'oxygene de differents organismes. Cette strategie est plus particulierement appliquee au trypanosoma cruzi (responsable de la maladie de chagas, trypanosomiase de l'amerique du sud) parasite tres sensible aux m

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Частини книг з теми "Nitro-Imidazole derivative"

"Electrochemical studies on the reduction of nitro-containing imidazole and benzimidazole compounds as antiparasitic agents." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.29.3.

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Imidazole compounds are widely used in therapy against parasitic and bacterial diseases. Very important representatives are nitro group-containing drugs such as tinidazole, metronidazole, etc. It is known that the nitro group can undergo bioreduction through transformation in radical anion, radical dianion, nitroso- and hydroxylamino derivative in hypoxic conditions becoming toxic because of the connection to the DNA with covalent bonds. Tinidazole was developed as an analogue of metronidazole and has been in use in Europe since 1969. It is used against protozoal parasites and a great number o

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