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Статті в журналах з теми "Nitro-Imidazole derivative"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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1

Afandi, Trisno, Bambang Purwono, and Winarto Haryadi. "Effect of Nitro Group on Imidazole Derivative as Colorimetric Chemosensor for Amines." Key Engineering Materials 840 (April 2020): 385–91. http://dx.doi.org/10.4028/www.scientific.net/kem.840.385.

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Chemosensor of imidazole derivative (4-(4,5-diphenyl-1H-imidazol-2-yl)-2-methoxy-6-nitrophenol) (IMD-1) has been synthesized and tested for amines sensor. IMD-1 was synthesized from the reaction of 5-nitrovanillin, 1,2-diphenylethane-1,2-dione (benzil), and ammonium acetate using reflux method. IMD-1 showed fast respond and color change from light orange to orange in naked eye compared with the imidazole derivative without nitro group (IMD-0). The IMD-1 could detect butylamine quantitatively with detection limit of 1.03 x 10-4 M.

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2

Kubicki, Maciej, Teresa Borowiak, Grzegorz Dutkiewicz, Stanisław Sobiak, and Iwona Weidlich. "1,2-Dimethyl-4-nitro-5-morpholinoimidazole and its hydrate: a case of a centrosymmetric–noncentrosymmetric ambiguity." Acta Crystallographica Section B Structural Science 59, no. 4 (2003): 487–91. http://dx.doi.org/10.1107/s010876810301070x.

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The compound studied is 1,2-dimethyl-4-nitro-5-morpholinoimidazole (1) in its anhydrous (1) and hydrated [(1)·H2O] crystal forms. In spite of the strong electron-withdrawing effect of the nitro group, the unsubstituted N atom of the imidazole moiety retains its basic character and acts as an acceptor for intermolecular hydrogen bonds: either weak C—H...N bonds in (1) or strong O—H...N bonds, with the water molecules, in (1)·H2O. The packing in (1) is determined by weak C—H...N and C—H...O hydrogen bonds, van der Waals interactions and the stacking of imidazole fragments. The crystal structure

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3

Dr., Sonali Banpure* Bhalekar Pournima Ingale Pramod Matade Siddhesh Mhase Pratiksha. "Design, In Silico Evaluation, Synthesis and Biological Evaluation Of 4-Nitroimidazole Derivatives." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1621–27. https://doi.org/10.5281/zenodo.15381646.

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This study aimed to design and evaluate novel antitubercular agents using computational methods. Four derivatives of isoniazid and acyclovir were designed and subjected to molecular docking studies against the 3IX2 protein. The results showed that the first derivative had the lowest binding energy (-11.58) and formed three hydrogen bonds with the protein. ADMET analysis was performed to evaluate the pharmacokinetic properties of the designed compounds. Based on the molecular docking and ADMET analysis, the first derivative was identified as the most promising compound for further development a

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4

Kubicki, Maciej. "Two tautomers in one crystal: 4(5)-nitro-5(4)-methoxyimidazole." Acta Crystallographica Section B Structural Science 60, no. 2 (2004): 191–96. http://dx.doi.org/10.1107/s0108768104003179.

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The case of prototropic annular tautomerism in an imidazole derivative has been found. The crystal structure contains a 50:50 mixture of two tautomers: 4-nitro-5-methoxyimidazole and 5-nitro-4-methoxyimidazole. The X-ray experiment actually shows the superposition of these compounds; it appears as if the structure is centrosymmetric and the N—H hydrogen atoms are disordered over two ring N atoms. Owing to the hydrogen-bond pattern, the values of their site occupation factors have to be exactly equal to 1/2. The molecules are connected into a three-dimensional network by means of N—H...N and C—

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5

Al-Abboodi1, Doaa Hashim, and Naeemah Al-lami. "NEW METHDOLOGY OF SYNTHESIS PYRAZOLO- THIAZOLO DERIVATIVES WITH STUDY ANTIMICROBAL ACTIVITIES." iraqi journal of market research and consumer protection 16, no. 1 (2024): 1–12. http://dx.doi.org/10.28936/jmracpc16.1.2024.(1).

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In this contribution, new derivatives of thiosemicarbazon, cyclic thiazolidinone, yilidine thiazolidinone, and parazolo-thiazole were synthesized, starting from the reaction of 2 -aminobenzothiazole with p-bromo phenacyl bromide to give the first step of 2(4-bromo phenyl) imidazole (2,1 -b) benzo thiazole (1). Compound (1) then was subjected under Viels Myer Haack to yield 3-carbaldehyde linking with imidazo-benzothiazol (2). Compound (2) condensed with thiosemicarbazide togivenewsynthesis of thiosemicarbazon derivative (3). Compound 4-Oxo-1,3-thiazolidine (4) was constituted from reacting com

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6

Heras Martinez, Hector Mario, David Chavez Flores, Patrick C. Hillesheim, Siddappa Patil, and Alejandro Bugarin. "Crystal structure and spectroscopic properties of (E)-1,3-dimethyl-2-[3-(4-nitrophenyl)triaz-2-enylidene]-2,3-dihydro-1H-imidazole." Acta Crystallographica Section E Crystallographic Communications 77, no. 2 (2021): 130–33. http://dx.doi.org/10.1107/s2056989021000426.

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The title compound (E)-1,3-dimethyl-2-[3-(4-nitrophenyl)triaz-2-enylidene]-2,3-dihydro-1H-imidazole, C11H12N6O2, has monoclinic (C2/c) symmetry at 100 K. This triazene derivative was synthesized by the coupling reaction of 1,3-dimethylimidazolium iodide with 1-azido-4-nitro benzene in the presence of sodium hydride (60% in mineral oil) and characterized by 1H NMR, 13C NMR, IR, mass spectrometry, and single-crystal X-ray diffraction. The molecule consists of six-membered and five-membered rings, which are connected by a triazene moiety (–N=N—N–). In the solid-state, the molecule is found to be

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7

Mohamed, Shaaban K., Jim Simpson, Adel A. Marzouk, et al. "Multicomponent green synthesis, spectroscopic and structural investigation of multi-substituted imidazoles. Part 1." Zeitschrift für Naturforschung B 70, no. 11 (2015): 809–17. http://dx.doi.org/10.1515/znb-2015-0067.

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AbstractTen 1,2,4,5-tetra-substituted imidazole derivatives have been synthesized with a 2-hydroxyethy substituent at the 1-nitrogen atom and potentially electron releasing hydroxy-, methoxy-, dimethylamino- or nitro substituents in various positions on the benzene ring located on the 2-carbon atom. The prototypical derivative with an unsubstituted phenyl ring at the 2-position is also reported. The compounds are obtained in excellent yields (average 86%) via a four-component cyclocondensation reaction of benzil, ethanolamine, and the appropriate aromatic carbaldehyde together with ammonium ac

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8

Huang, Xi-Shou, Li-Sheng Wang, Yong Yin, et al. "Synthesis, Characterization and Bioactivity Research of a Derivative of Secnidazole: 1-(2-Chloropropyl)-2-methyl-5-nitro-1H-imidazole." Journal of Chemical Crystallography 41, no. 9 (2011): 1360–64. http://dx.doi.org/10.1007/s10870-011-0104-9.

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9

Amini, S. K., N. L. Hadipour, and F. Elmi. "A study of hydrogen bond of imidazole and its 4-nitro derivative by ab initio and DFT calculated NQR parameters." Chemical Physics Letters 391, no. 1-3 (2004): 95–100. http://dx.doi.org/10.1016/j.cplett.2004.04.065.

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10

Pawar, Harshal Ashok, and Pooja Rasiklal Joshi. "Development and Evaluation of Taste Masked Granular Formulation of Satranidazole by Melt Granulation Technique." Journal of Pharmaceutics 2014 (February 12, 2014): 1–7. http://dx.doi.org/10.1155/2014/789676.

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Анотація:

Drugs from nitroimidazole category are generally bitter in taste. Oral formulation with bitter taste is not palatable. Geriatrics and pediatrics patients usually suffer from swallowing difficulties. Many other patients in some disease conditions avoid swallowing tablets. Satranidazole is a new nitro-imidazole derivative with bitter taste and is available in market as film coated tablet. The purpose of this research was to mask the bitter taste of Satranidazole by coating complexation with low melting point wax and Eudragit EPO. Different types of wax (glyceryl monostearate, stearic acid and ce

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11

Tafazzoli, M., and S. K. Amini. "A survey of hydrogen bonding in imidazole and its 4-nitro derivative by ab initio and DFT calculations of chemical shielding." Chemical Physics Letters 431, no. 4-6 (2006): 421–27. http://dx.doi.org/10.1016/j.cplett.2006.09.089.

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12

Cvejn, Daniel, Věra Klimešová та Filip Bureš. "α-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity". Open Chemistry 10, № 5 (2012): 1681–87. http://dx.doi.org/10.2478/s11532-012-0087-1.

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Abstractα-Amino acid-derived 2-phenylimidazole derivatives were designed, synthesized, and further investigated as potential antimycobacterial agents. The synthesis of target imidazole derivatives involved the transformation of Cbz-protected α-amino acids (Ala, Val, Phe, Leu, iLe, and Pro) into α-diazoketones and α-bromoketones, respectively. Subsequent treatment of α-bromoketones with (4-nitro)benzamidine afforded imidazole derivatives bearing α-amino acid residue appended to the imidazole C4 and (4-nitro)phenyl ring in the position C2. Antimycobacterial activities of both series of compounds

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13

Veeraragavan, Vijayakumar, Radhakrishnan Narayanaswamy, and Rameshkumar Chidambaram. "PREDICTING THE BIODEGRADABILITY NATURE OF IMIDAZOLE AND ITS DERIVATIVES BY MODULATING TWO HISTIDINE DEGRADATION ENZYMES (UROCANASE AND FORMIMINOGLUTAMASE) ACTIVITIES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (2017): 383. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.20999.

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Objectives: The biodegradation pathway of substituted imidazole ring compounds has been reported to have close analogy to the histidine degradation pathway. This prompted the present study to be carried out on 12 selected imidazole and its derivatives which are 1-imidazole, 1, 2-dimethylimidazole, 1-ethyl imidazole, 2-ethyl-4-methylimidazole, 2-isopropylimidazole, 2-Isopropyl-4-nitro-1H-imidazole, 1-methylimidazole, 2-methyl-5-nitroimidazole, 2-methyl-1-vinylimidazole, 1-nitro imidazole, 1-phenyl imidazole, and 1-vinylimidazole.Methods: The imidazole and its derivatives were evaluated on the d

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14

Quinlivan, Patrick J., Ja-Shin Wu, and Rita K. Upmacis. "Crystal structure of metronidazolium tetrachloridoaurate(III)." Acta Crystallographica Section E Crystallographic Communications 71, no. 7 (2015): 810–12. http://dx.doi.org/10.1107/s2056989015010798.

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Metronidazole (MET) [systematic names: 1-(2-hydroxyethyl)-2-methyl-5-nitro-1H-imidazole and 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol] is a medication that is used to treat infections from a variety of anaerobic organisms. As with other imidazole derivatives, metronidazole is also susceptible to protonation. However, there are few reports of the structures of metronidazolium derivatives. In the title compound, (C6H10N3O3)[AuCl4] [systematic name: 1-(2-hydroxyethyl)-2-methyl-5-nitro-1H-imidazol-3-ium tetrachloridoaurate(III)], the asymmetric unit consists of a metronidazolium cation, [H(MET)

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15

Yakovychuk, N. D., S. Y. Deyneka, A. M. Grozav, A. V. Humenna, V. B. Popovych та V. S. Djuiriak. "Аntifungal activity of 5-(2-nitrovinyl) imidazoles and their derivatives against the causative agents of vulvovaginal candidiasis". Regulatory Mechanisms in Biosystems 9, № 3 (2018): 369–73. http://dx.doi.org/10.15421/021854.

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Development of resistance of yeast-like fungi belonging to the Candida genus to the existing antifungal medicines as well as the high toxicity and low tolerance of these medicines in many cases stipulate the acute need for new antibiotic compounds. In this context, an extremely promising group of chemical substances is imidazole derivatives. Therefore, the search for more active and less toxic medical preparations based on imidazole is a relevant and important issue for medical practice. Considering the urgent demand for new antifungal preparations, four new nitro containing imidazole derivati

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16

Poulain, Agnieszka, Maciej Kubicki, and Claude Lecomte. "Isomorphism and solid solution as shown by an accurate high-resolution diffraction experiment." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 70, no. 6 (2014): 973–82. http://dx.doi.org/10.1107/s2052520614021325.

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High-resolution crystal structure determination and spherical and multipolar refinement enabled an organic solid solution of 1-(4′-chlorophenyl)-2-methyl-4-nitro-1H-imidazole-5-carbonitrile and 5-bromo-1-(4′-chlorophenyl)-2-methyl-4-nitro-1H-imidazole to be found, which would not normally be revealed using only standard resolution data (ca0.8 Å), as the disordered part is only visible at high resolution. Therefore, this new structure would have been reported as just another polymorphic form, even more reasonably as isostructural with other derivatives. To the best of our knowledge this is the

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17

Osorio, Luis F. B., Samir A. Carvalho, Edson F. da Silva, et al. "Different molecular conformations in the crystal structures of three 5-nitroimidazolyl derivatives." Acta Crystallographica Section E Crystallographic Communications 74, no. 3 (2018): 380–84. http://dx.doi.org/10.1107/s2056989018002876.

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The crystal structures of (E)-1-methyl-5-nitro-1H-imidazole-2-carbaldehydeO-benzyloxime, C12H12N4O3, (I), (E)-1-methyl-5-nitro-1H-imidazole-2-carbaldehydeO-(4-fluorobenzyl) oxime, C12H11FN4O3, (II), and (E)-1-methyl-5-nitro-1H-imidazole-2-carbaldehydeO-(4-bromobenzyl) oxime, C12H11BrN4O3, (III), are described. The dihedral angle between the ring systems in (I) is 49.66 (5)° and the linking Nm—C—C=N (m = methylated) bond shows ananticonformation [torsion angle = 175.00 (15)°]. Compounds (II) and (III) are isostructural [dihedral angle between the aromatic rings = 8.31 (5)° in (II) and 5.34 (15)

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18

Hadisaputra, Saprizal, Zohrul Iskandar, and Dina Asnawati. "Prediction of the Corrosion Inhibition Efficiency of Imidazole Derivatives: A Quantum Chemical Study." Acta Chimica Asiana 2, no. 1 (2019): 88. http://dx.doi.org/10.29303/aca.v2i1.15.

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This study aims to determine the the efficiency of corrosion inhibition of imidazole derivatives in carbon steel based on quantum chemical parameters. Density functional theory method was applied in this study. Corrosion inhibition efficiency values are strongly influenced by substituent groups. Corrosion inhibition efficiency values have a linear correlation with quantum chemical parameters. The amine substituent increased the value of corrosion inhibition efficiency, in contrast nitro group reduced the efficiency of corrosion inhibition. The predicted corrosion inhibition efficiency data

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19

Al-Soud, Yaseen A., Ala’a H. Al-Ahmad, Luay Abu-Qatouseh, et al. "Nitroimidazoles Part 9. Synthesis, molecular docking, and anticancer evaluations of piperazine-tagged imidazole derivatives." Zeitschrift für Naturforschung B 76, no. 5 (2021): 293–302. http://dx.doi.org/10.1515/znb-2020-0200.

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Abstract New piperazine-tagged imidazole derivatives were synthesized via reaction of 1-alkyl/aryl-5-bromo-2-alkyl-4-nitro-1H-imidazoles 1–3 with piperazine nucleophiles. Nine selected compounds were assessed for their antiproliferative inhibition potency against five human cancer cell lines (MCF-7, PC3, Du145, HepG2 and Dermal/Fibroblast). Compounds 7 and 10 are the most potent anticancer agents on HepG2 cell line with IC50 values of (5.6 ± 0.5 µm) and (29.6 ± 7.6 µm) respectively, and on MCF-7 with IC50 values of (32.1 ± 5.6 µm) and (46.2 ± 8.2 µm) respectively. The molecular docking of comp

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20

Sharma, D., G. K. Sharma, D. Pathak, and M. C. Sharma. "SYNTHESIS AND EVALUATION OF ANTIBACTERIAL, ANTHELMINTIC ACTIVITIES OF SUBSTITUTED BENZIMIDAZOLE DERIVATIVES." INDIAN DRUGS 54, no. 06 (2017): 69–76. http://dx.doi.org/10.53879/id.54.06.11797.

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The study was undertaken to synthesize and evaluate antibacterial, anthelmintic activities of N’ (substituted benzylidene)-2-(2-alkyl/aryl-1H-benzo[d] imidazole-1yl) acetohydrazide derivatives. All the novel benzimidazole derivatives were screened for anthelmintic activity against Pherituma posthuma species of earthworms and antibacterial activity against following bacterial strains: S. aureus, B.subtilis (Gram positive) and E. coli and P.aeruginosa (Gram negative). The antibacterial data suggest that compounds having nitro and hydroxyl substitution were more potent and the anthelmintic data s

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21

Al-Soud, Yaseen, Najim Al-Masoudi, Hamed Hassan, Erik De Clercq, and Christophe Pannecouque. "Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives." Acta Pharmaceutica 57, no. 4 (2007): 379–93. http://dx.doi.org/10.2478/v10007-007-0031-7.

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Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivativesA series of 2-alkylthio-1-[4-(1-benzyl-2-ethyl-4-nitro-1H- -imidazol-5-yl)-piperazin-1-y]lethanones (3-9) and alkyl- [4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-piperazin- -1-yl)ketones (11-20) as well as the indole analogue22were synthesized from 4-nitro-5-piperazinyl imidazole derivative1, with the aim to develop newly non-nucleoside reverse transcriptase inhibitors (NNRTIs). The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compound2showed i

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22

Oliveira, Ana P. A., Isabella P. Ferreira, Angel A. Recio Despaigne, et al. "Structural studies and antileishmanial activity of 2-acetylpyridine and 2-benzoylpyridine nitroimidazole-derived hydrazones." Acta Crystallographica Section C Structural Chemistry 75, no. 3 (2019): 320–28. http://dx.doi.org/10.1107/s2053229619001529.

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Three imidazole hydrazone compounds, namely 2-(4-nitro-1H-imidazol-1-yl)-N′-[1-(pyridin-2-yl)ethylidene]acetohydrazide, C12H12N6O3, (1), 2-(2-nitro-1H-imidazol-1-yl)-N′-[1-(pyridin-2-yl)ethylidene]acetohydrazide, C12H12N6O3, (2), and 2-(2-nitro-1H-imidazol-1-yl)-N′-[(phenyl)(pyridin-2-yl)methylidene]acetohydrazide, C17H14N6O3, (3), were obtained and fully characterized, including their crystal structure determinations. While all the compounds proved not to be cytotoxic to J774.A1 macrophage cells, (1) and (3) exhibited activity against Leishmania chagasi, whereas (2) was revealed to be inactiv

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23

Abdullah, Asmaa M., Abdull Jabar Kh Attia, and Sergei N. Shtykov. "Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents." Al-Mustansiriyah Journal of Science 35, no. 4 (2024): 52–63. https://doi.org/10.23851/mjs.v35i4.1572.

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Background: Benzimidazoles are a class of compounds characterized by a fusion of benzene and imidazole rings. This unique structure endows them with a broad spectrum of biological activities, making them invaluable in medicinal and pharmaceutical research. The benzene ring provides aromatic stability, while the imidazole ring offers a site for various chemical modifications, enhancing their versatility and functionality. Benzimidazoles are known for their diverse pharmacological properties, including antimicrobial, antiviral, anticancer, anti-inflammatory, and antiparasitic. Objective: Synthes

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24

Boncel, Sławomir, Kinga Saletra, Barbara Hefczyc, and Krzysztof Z. Walczak. "Michael-type addition of azoles of broad-scale acidity to methyl acrylate." Beilstein Journal of Organic Chemistry 7 (February 8, 2011): 173–78. http://dx.doi.org/10.3762/bjoc.7.24.

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An optimisation of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pK a units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-4(5)-nitroimidazole, 5(4)-bromo-2-methyl-4(5)-nitroimidazole and 3-nitro-1,2,4-triazole to methyl acrylate as an acceptor was carried out. The optimisation process involved the use of an appropriate basic catalyst (DBU, DIPEA, NaOH, NaH, TEDA), a donor/base/acceptor ratio and the reaction temperature. The reactions were performed in DMF as so

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25

Iradyan, M. A., A. Kh Aivazyan, V. S. Mirzoyan, et al. "Imidazole derivatives. Synthesis and biological activity of derivatives of 4-nitro-5-thioimidazole." Pharmaceutical Chemistry Journal 22, no. 4 (1988): 287–92. http://dx.doi.org/10.1007/bf00768245.

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26

Iradyan, M. A., A. Kh Ayvazyan, V. S. Mirzoyan, et al. "Imidazole derivatives. XIX. Synthesis and biological activity of 4-nitro-5-thioimidazole derivatives." Pharmaceutical Chemistry Journal 21, no. 6 (1987): 403–8. http://dx.doi.org/10.1007/bf00758627.

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27

Juspin, Thierry, Laura Zink, Maxime D. Crozet, Thierry Terme, and Patrice Vanelle. "High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach." Molecules 16, no. 8 (2011): 6883–93. http://dx.doi.org/10.3390/molecules16086883.

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28

Gerasimova, Elena L., Elena R. Gazizullina, Maria V. Borisova, et al. "Design and Antioxidant Properties of Bifunctional 2H-Imidazole-Derived Phenolic Compounds—A New Family of Effective Inhibitors for Oxidative Stress-Associated Destructive Processes." Molecules 26, no. 21 (2021): 6534. http://dx.doi.org/10.3390/molecules26216534.

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Анотація:

The synthesis of inhibitors for oxidative stress-associated destructive processes based on 2H-imidazole-derived phenolic compounds affording the bifunctional 2H-imidazole-derived phenolic compounds in good-to-excellent yields was reported. In particular, a series of bifunctional organic molecules of the 5-aryl-2H-imidazole family of various architectures bearing both electron-donating and electron-withdrawing substituents in the aryl fragment along with the different arrangements of the hydroxy groups in the polyphenol moiety, namely derivatives of phloroglucinol, pyrogallol, hydroxyquinol, in

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29

Vedekhina, T. S., M. V. Chudinov, and A. Yu Lukin. "Design and synthesis of 4-nitroimidazole derivatives with potential antitubercular activity." Fine Chemical Technologies 18, no. 3 (2023): 219–29. http://dx.doi.org/10.32362/2410-6593-2023-18-3-219-229.

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Objectives. To develop the procedures for synthesis of hybrid molecules with potential anti-tubercular activity containing heterocyclic cores of 4-nitroimidazole and 1,3,4-thiadiazole within the framework of a double-drug strategy and predict bioactivity of target structures and drug-likeness physicochemical parameters.Methods. Target compounds were prepared by classical organic synthesis methods. The structure of the obtained compounds was characterized by melting points, 1H and 13C nuclear magnetic resonance spectroscopy, and high-resolution mass spectrometry. The calculation of the physicoc

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30

Olender, Dorota, Lucjusz Zaprutko, Anna Mertas, Ewelina Szliszka, Dariusz Wyrozumski, and Wojciech Król. "Anti-Candida Activity of 4-Morpholino-5-Nitro- and 4,5-Dinitro-Imidazole Derivatives." Pharmaceutical Chemistry Journal 51, no. 12 (2018): 1063–67. http://dx.doi.org/10.1007/s11094-018-1741-5.

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31

Cert, Arturo, Pedro Delgado-Cobos, and Mariana Trujillo Pérez-Lanzac. "Mass spectrometry of imidazole-4(5)-carboxaldehyde and some 1-methyl and nitro derivatives." Organic Mass Spectrometry 21, no. 8 (1986): 499–505. http://dx.doi.org/10.1002/oms.1210210810.

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32

Shivhare, Vineeta Devi, and Prashant Vinode. "Role of Indian herbal medicines and Nitro Imidazole derivatives in the management of ulcer." Advance Pharmaceutical Journal 8, no. 6 (2023): 155–64. http://dx.doi.org/10.31024/apj.2023.8.6.3.

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33

Li, Luyong, Jie Hu, Yuqing Fu, et al. "Direct Regioselective C-H Cyanation of Purines." Molecules 28, no. 3 (2023): 914. http://dx.doi.org/10.3390/molecules28030914.

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A direct regioselective C-H cyanation of purines was developed through a sequential triflic anhydride activation, nucleophilic cyanation with TMSCN, followed by a process of base-mediated elimination of triflous acid (CF3SO2H). In most cases, the direct C-H cyanation occurred on the electron-rich imidazole motif of purines, affording 8-cyanated purine derivatives in moderate to excellent yields. Various functional groups, including allyl, alkynyl, ketone, ester, nitro et al. were tolerated and acted as a C8 directing group. The electron-donating 6-diethylamino, as C2-directing group substituen

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34

SENGE, MATHIAS O. "Axial Ligand Effects in Sterically Strained Porphyrins: A Crystallographic Study of Five- and Six-coordinated Metal Complexes of 2,3,7,8,12,13,17,18-Octaethyl-5,10,15,20-tetranitroporphyrin." Journal of Porphyrins and Phthalocyanines 02, no. 02 (1998): 107–21. http://dx.doi.org/10.1002/(sici)1099-1409(199803/04)2:2<107::aid-jpp57>3.0.co;2-t.

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Porphyrins with steric hindrance at the periphery are known to exhibit severely non-planar macrocycle conformations. Among other dodecasubstituted porphyrins, the title compound has been studied widely and shows a typical saddle-distorted macrocycle. The specific conformation of the porphyrin leads to the formation of distinct cavities on both sides of the macrocycle. Compared to planar porphyrins this should increase steric interactions between the macrocycle and axial ligands in five- and six-coordinated metal derivatives. In order to study the influence of different axial ligands on the con

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35

Zaderenko, P., M. S. Gil, P. López, P. Ballesteros, I. Fonseca, and A. Albert. "Diethyl 2-Benzimidazol-1-ylsuccinate–Picric Acid (1/1) – An Inclusion Molecular Complex." Acta Crystallographica Section B Structural Science 53, no. 6 (1997): 961–67. http://dx.doi.org/10.1107/s0108768197008562.

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The crystal structure of the diethyl 2-benzimidazol-1-ylsuccinate–picric acid (1/1) molecular complex has been determined by X-ray diffraction analysis. Diethyl 2-benzimidazol-l-ylsuccinate molecules form channels along the a axis, in which the picric acid molecules are located. The benzimidazole moiety and the phenol group are held together by hydrogen bonding between the hydrogen of the phenol and the N3 atom of benzimidazole. Additionally, this hydrogen forms an intramolecular hydrogen bond with one O atom of the ortho-nitro group, thus producing a bifurcated hydrogen bond. 1H NMR spectra i

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36

Lomov, D. A. "Recyclization of 1,3-dialkyl-6-nitro-1H-imidazo[4,5-b]pyridine-2,5(3H,4H)-diones into imidazole derivatives." Russian Journal of Organic Chemistry 52, no. 1 (2016): 51–53. http://dx.doi.org/10.1134/s1070428016010103.

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37

Maliborski, Artsiom, Roman Sverdlov, Sviatoslav Brinkevich, Oleg Shadyro, and Yuri Grigoriev. "Interaction of 1,2,4-triazole and imidazole nitro derivatives with carbon- and oxygen-centered radicals: a steady-state radiolysis study." Free Radical Biology and Medicine 177 (December 2021): S77—S78. http://dx.doi.org/10.1016/j.freeradbiomed.2021.08.088.

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38

Bendgude, R. D., M. S. Kondawar, R. V. Hirave, and S. B. Patil. "Synthesis and Evaluation of Novel 2-bromo- 4-nitro-1, 5-diphenyl substituted -1-H-imidazole Derivatives as Anticancer Agent." Journal of Chemistry and Chemical Sciences 8, no. 5 (2018): 865–69. http://dx.doi.org/10.29055/jccs/654.

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39

Lohidakshan, Krishnakumar, Manju Rajan, Andhale Ganesh, Mathew Paul, and Jithu Jerin. "Pass and Swiss ADME collaborated in silico docking approach to the synthesis of certain pyrazoline spacer compounds for dihydrofolate reductase inhibition and antimalarial activity." Bangladesh Journal of Pharmacology 13, no. 1 (2018): 23. http://dx.doi.org/10.3329/bjp.v13i1.33625.

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<p class="Abstract">New series of pyrazoline spacer compounds were prepared by the reaction between benzimidazole chalcones and (2-methyl-5-nitro-imidazole-1-yl)-acetic acid hydrazide by the sensible use of Michael addition. The building blocks used for the synthesis of pyrazoline derivatives were opted by using virtual screening by molinspiration search engine. The hypothetically resulted pyrazoline spacer compounds from this list are checked for their reliability on other in silico drug designing online web services like PASS online bioactivity, Swiss ADME predictor. The docking study

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40

Byabartta, P., Sk Jasimuddin, B. K. Ghosh, C. Sinha, A. M. Z. Slawin, and J. D. Woollins. "Nitro–ruthenium(ii)–arylazoimidazoles: synthesis, spectra, crystal structure and electrochemistry of dinitro-bis{1-alkyl-2-(arylazo)imidazole}ruthenium(ii). Nitro–nitroso derivatives and reactivity of the electrophilic {Ru-NO}6system." New J. Chem. 26, no. 10 (2002): 1415–24. http://dx.doi.org/10.1039/b204442k.

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41

Anupam, Anupam, Mohammed Al-Bratty, Hassan Ahmad Alhazmi, et al. "Synthesis and biological evaluation of triphenyl-imidazoles as a new class of antimicrobial agents." European Journal of Chemistry 9, no. 4 (2018): 369–74. http://dx.doi.org/10.5155/eurjchem.9.4.369-374.1785.

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Newer triphenyl-imidazole derivatives (4a-h) were synthesized in good yields by the reaction of benzil and substituted benzaldehydes in equimolar quantities and refluxing the product with acetyl chloride thereafter. Structures were confirmed by using FT-IR, 1H NMR and 13C NMR spectroscopic methods. All the synthesized compounds were tested for their antimicrobial activity using agar diffusion technique against Gram positive (Staphhylococcus aureus and Bacillus subtilis), Gram negative (Escherichia coli and Pseudomonas aureginosa) as well as Fungal strain (Candida albicans). Interestingly compo

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42

Byabartta, Prithwiraj. "Synthesis, Spectra and Electrochemistry of Dinitro-bis-{1-alkyl-2-(arylazo) imidazole} Ruthenium(II). Nitro-nitroso Derivatives and Reactivity of the Electrophilic {Ru-NO}6System." Transition Metal Chemistry 30, no. 7 (2005): 804–13. http://dx.doi.org/10.1007/s11243-005-5629-3.

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43

Zubenko, A. A., L. N. Divaeva, L. N. Fetisov, et al. "Search for fungistatics in the imidazole series." Veterinaria i kormlenie, no. 5 (October 2022). http://dx.doi.org/10.30917/att-vk-1814-9588-2022-5-4.

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New imidazole derivatives with fungistatic activity were synthesized at the NCRSRVI branch of FSBSC Federal Rostov Agrarian Scientific Center. The initial compound 4,5-dichlorimidazole was obtained according to the method described in the literature [3]. Structures 1, 4, 6, 7, 8 - 11, 14 - 17, 19, 20, 22, 24 they were synthesized by alkylation of 4,5-dichlorimidazole with corresponding halide alkyls in an alkaline medium. Alcohol 5 was obtained by reducing ketone with sodium borohydride in ethanol. Bigeterocycles 10, 13 were obtained by the reaction of 4,5-dichlorimidazole with corresponding c

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44

AMINI, S. "A study of hydrogen bond of imidazole and its 4-nitro derivative by ab initio and DFT calculated NQR parameters." Chemical Physics Letters, May 2004. http://dx.doi.org/10.1016/s0009-2614(04)00621-9.

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45

Zhou, Wei, Junyuan Tang, Xinchong Zhou, and Jinbing Liu. "Tyrosinase inhibition by novel benzimidazole-thione Schiff base derivatives." Letters in Drug Design & Discovery 19 (February 10, 2022). http://dx.doi.org/10.2174/1570180819666220210100037.

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Background: Tyrosinase is the enzyme responsible for the conversion of tyrosine to dopaquinone, which is related to melanoma, neurodegenerative disorders, freckles, pigmented acne and age spots. Controlling the tyrosinase activity could be an important way for treating overproduction of melanin. Objective: The development of safe and specific tyrosinase inhibitors could be used to treat hypermelanosis. Methods: 5-nitro-1H-benzo[d]imidazole-2(3H)-thione was synthesized from 4-nitro-o-phenylenediamine and carbon disulfide. The nitro group of 5-nitro-1H- S-1 ESI-HRMS benzo[d]imidazole-2(3H)-thion

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46

Silva, Rafaela Corrêa, and Maurício Silva dos Santos. "Synthesis of Novel Nitroimidazole‐Pyrazole Hybrids via an Attractive Methodology of N‐Alkylation of 4(5)‐Nitro‐1H‐imidazole." Journal of Heterocyclic Chemistry, September 12, 2024. http://dx.doi.org/10.1002/jhet.4897.

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ABSTRACTImidazole is one of the most important heterocyclic rings. This nucleus can be found in a plethora of substances in different knowledge areas such as medicinal, agrochemical, polymer, and dyestuff. N‐alkylation reactions involving N − 1 atom is a remarkable tool to synthesize many imidazole derivatives which can be attached to a great variety of functional groups. In this work, we synthesized 10 new intermediates 4‐chlorobutyl 1‐aryl‐1H‐pyrazole‐4‐carboxylates 3(a–j) from 1‐aryl‐1H‐pyrazole‐4‐carbonyl chlorides, obtained from 1‐aryl‐1H‐pyrazole‐4‐carboxylic acids 4(a–j), and 4‐chlorobu

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47

DA SILVA, ANA VIRGINIA LIMA, GREYCE LURI SASAHARA, FLORÊNCIO SOUSA GOUVEIA, et al. "Antioxidant Activity of Ruthenium Complexes Containing Nitro‐imidazole Derivatives." FASEB Journal 33, S1 (2019). http://dx.doi.org/10.1096/fasebj.2019.33.1_supplement.670.18.

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48

Aydoğan, Gözde, and Mehtap Kutlu. "Mutagenic activities of ten imidazole derivatives in Salmonella typhimurium." Biologia 62, no. 1 (2007). http://dx.doi.org/10.2478/s11756-007-0008-5.

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AbstractTen imidazole derivatives were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 both in the absence and presence of metabolic activation by the microsomal fraction S9 mix. In a general manner, derivatives tested exhibited a greater mutagenic activity in the TA100 strain comparing to the responses in TA 98. In the standard plate incorporation assay, 8 of these substances (80%) were found to be mutagenic for at least one of the two strains in the presence or absence of metabolic activation. Two compounds showed positive results in TA98 and 6 compounds were also mu

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49

Sharma, Anjali, Kshetrimayum Dhruba Singh, and Mridula Guin. "Theoretical Investigation of Energetic Materials Based on Imidazole Framework Featuring Azido/Nitro/Nitrato/Fluoro Groups." Journal of Physical Organic Chemistry, October 2024. http://dx.doi.org/10.1002/poc.4661.

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ABSTRACTDevelopment of new high‐energy materials (HEMs) is one of the thrust areas of research. These compounds are important for various applications such as propellants, gas generations, explosives in mining, construction, civil and military applications, and safety equipment for national security and defense. HEMs based on imidazole frameworks are currently getting research spotlight due to their exceptional detonation performance with optimum sensitivity. This study reports five imidazole derivatives containing azido/nitro/nitrato/fluoro functional groups. These groups are viable options t

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50

Li, Butong, Lulin Li, and Sijia Chen. "Thermal stability and detonation character of nitro-substituted derivatives of imidazole." Journal of Molecular Modeling 25, no. 9 (2019). http://dx.doi.org/10.1007/s00894-019-4190-5.

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