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1

Armstrong, C., KW Burak, and PL Beck. "Benzocaine-Induced Methemoglobinemia: A Condition of which all Endoscopists Should Be Aware." Canadian Journal of Gastroenterology 18, no. 10 (2004): 625–29. http://dx.doi.org/10.1155/2004/620203.

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Анотація:
Methemoglobinemia is a rare complication that can occur with the use of benzocaine-containing compounds. Two cases of methemoglobinemia are reported, and the pathophysiology and treatment of methemoglobinemia are reviewed. Both patients received topical 20% benzocaine spray before endoscopy. Immediately following the procedure, there was a reduction in O2saturation assessed by pulse oximetry that was refractory to O2therapy. Dramatic peripheral and central cyanosis developed. O2saturation measured by pulse oximetry ranged from 83% to 87% on O2by nasal prongs and 100% O2by a nonrebreathing mask
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2

SEO, YOOJIN, KAZUYA MATSUMOTO, YOUNG MAN PARK, MOTOHIKO MOHRI, SHIGEAKI MATSUOKA, and KWANG PAK PARK. "Changes in sleep patterns during He-O2saturation dives." Psychiatry and Clinical Neurosciences 52, no. 2 (1998): 141–42. http://dx.doi.org/10.1111/j.1440-1819.1998.tb00995.x.

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3

Bloos, F., and K. Reinhart. "The value of central venous O2saturation for assessment of tissue oxygenation." DMW - Deutsche Medizinische Wochenschrift 129, no. 48 (2004): 2601–4. http://dx.doi.org/10.1055/s-2004-836082.

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4

Moszura, Tomasz, Pawel Dryzek, Sebastian Goreczny, et al. "A 10-year single-centre experience in percutaneous interventions for multi-stage treatment of hypoplastic left heart syndrome." Cardiology in the Young 24, no. 1 (2013): 54–63. http://dx.doi.org/10.1017/s104795111200220x.

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AbstractObjectivesThe purpose of this paper is to report our 10 years of experience of interventional treatment of patients with hypoplastic left heart syndrome and to focus on the frequency, type, and results of percutaneous interventions during all the stages of palliation, considering the different techniques, devices, and complications.BackgroundConstant progress in surgical treatment of congenital heart defects in the last decade has significantly improved the prognosis for children with hypoplastic left heart syndrome. However, morbidity and mortality remain relatively high. Modern inter
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5

Crocker, George H., Balazs Toth, and James H. Jones. "Combined effects of inspired oxygen, carbon dioxide, and carbon monoxide on oxygen transport and aerobic capacity." Journal of Applied Physiology 115, no. 5 (2013): 643–52. http://dx.doi.org/10.1152/japplphysiol.01407.2012.

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Анотація:
We hypothesized that breathing hypoxic, hypercapnic, and CO-containing gases together reduces maximal aerobic capacity (V̇o2max) as the sum of each gas' individual effect on V̇o2max. To test this hypothesis, goats breathed combinations of inspired O2fraction (FiO2) of 0.06–0.21 and inspired CO2fraction of 0.00 or 0.05, with and without inspired CO that elevated carboxyhemoglobin fraction (FHbCO) to 0.02–0.45, while running on a treadmill at speeds eliciting V̇o2max. Individually, hypoxia and elevated FHbCOdecreased fractional V̇o2max(FV̇o2max, fraction of a goat's V̇o2maxbreathing air) in line
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6

Hall, David M., Kirk R. Baumgardner, Terry D. Oberley, and Carl V. Gisolfi. "Splanchnic tissues undergo hypoxic stress during whole body hyperthermia." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 5 (1999): G1195—G1203. http://dx.doi.org/10.1152/ajpgi.1999.276.5.g1195.

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Анотація:
Exposure of conscious animals to environmental heat stress increases portal venous radical content. The nature of the observed heat stress-inducible radical molecules suggests that hyperthermia produces cellular hypoxic stress in liver and intestine. To investigate this hypothesis, conscious rats bearing in-dwelling portal venous and femoral artery catheters were exposed to normothermic or hyperthermic conditions. Blood gas levels were monitored during heat stress and for 24 h following heat exposure. Hyperthermia significantly increased arterial O2saturation, splanchnic arterial-venous O2diff
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7

Morse, John WI, Sharyle A. Fowler, and Amy L. Morse. "Endoscopist-Administered Propofol: A Retrospective Safety Study." Canadian Journal of Gastroenterology 22, no. 7 (2008): 617–20. http://dx.doi.org/10.1155/2008/265465.

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Анотація:
BACKGROUND: Propofol is an anesthetic agent that is commonly used for conscious sedation. Propofol has advantages as a sedative agent for endoscopic procedures including rapid onset, short half-life and rapid recovery time. However, concerns exist regarding the potential for respiratory depression, hypotension, perforation due to deep sedation and the need for monitoring by an anesthetist. Propofol has been used under endoscopist supervision at the Stanton Territorial Hospital in Yellowknife, Northwest Territories since 1996 (approximately 7000 cases).METHODS: A retrospective chart review of e
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8

Kawakami, Michiro, Kazuo Makimoto, Osamu Noi, and Hiroaki Takahashi. "Feasibility of Pulse Oxymetry to Measure Arterial O2Saturation in Studies on Cochlear Blood Circulation." Acta Oto-Laryngologica 111, no. 5 (1991): 908–16. http://dx.doi.org/10.3109/00016489109138429.

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9

Milingos, D., D. Doumplis, K. Sieunarine, P. Savage, A. D. Lawson, and J. R. Smith. "Uterine arteriovenous malformation: fertility-sparing surgery using unilateral ligation of uterine artery and ovarian ligament." International Journal of Gynecologic Cancer 17, no. 3 (2007): 735–37. http://dx.doi.org/10.1136/ijgc-00009577-200705000-00028.

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Анотація:
Arteriovenous malformations (AVM) are rarely found in the uterus and are usually acquired. The method of treatment is determined by symptoms, desire for future fertility, extent, and location of the malformation. Selective ligation of the vessels supplying the malformation is an effective treatment option when conservative methods have failed and uterine preservation is of primary concern. Measurement of uterine O2saturation and perfusion index has been shown to be effective in the intraoperative assessment of uterine viability, pre- and postligation of pelvic vasculature. We present the case
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10

Dufu, Kobina, Ozlem Yalcin, Eilleen S. Y. Ao-ieong, et al. "GBT1118, a potent allosteric modifier of hemoglobin O2affinity, increases tolerance to severe hypoxia in mice." American Journal of Physiology-Heart and Circulatory Physiology 313, no. 2 (2017): H381—H391. http://dx.doi.org/10.1152/ajpheart.00772.2016.

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Анотація:
Adaptation to hypoxia requires compensatory mechanisms that affect O2transport and utilization. Decreased hemoglobin (Hb) O2affinity is considered part of the physiological adaptive process to chronic hypoxia. However, this study explores the hypothesis that increased Hb O2affinity can complement acute physiological responses to hypoxia by increasing O2uptake and delivery compared with normal Hb O2affinity during acute severe hypoxia. To test this hypothesis, Hb O2affinity in mice was increased by oral administration of 2-hydroxy-6-{[(2 S)-1-(pyridine-3-carbonyl)piperidin-2yl] methoxy}benzalde
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11

Rampil°, I. J., L. Litt°, and A. Mayevsky. "CORRELATED MULTIPLE-WAVELENGTH MONITORING OF LOCALIZED CEREBRO-CORTICAL NADH AND BRAIN MICRO-VESSEL HEMOGLOBIN O2SATURATION." Anesthesiology 75, no. 3 (1991): A446. http://dx.doi.org/10.1097/00000542-199109001-00446.

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12

Iwase, N., Y. Kikuchi, W. Hida, et al. "Effects of Repetitive Airway Obstruction on O2Saturation and Systemic and Pulmonary Arterial Pressure in Anesthetized Dogs." American Review of Respiratory Disease 146, no. 6 (1992): 1402–10. http://dx.doi.org/10.1164/ajrccm/146.6.1402.

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13

Zeraati, Mohammad Reza, and Taraneh Naghibi. "Acute Pulmonary Edema Following Administration of Magnesium Sulfate in a Pregnant Patient." Journal of Advances in Medical and Biomedical Research 27, no. 124 (2019): 43–46. https://doi.org/10.30699/jambs.27.124.43.

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Анотація:
Acute pulmonary edema affects 0.08% to 1.5% of women during pregnancy and during the postpartum period, and preeclampsia/eclampsia is a major obstetric cause of acute pulmonary edema. We present a case of a 23-year-old nulliparous woman who was referred totertiary medical center for preterm labor and dyspnea (Mousavi Hospital). The patient complained of having suddenly developed respiratory distress and a decrease in O2saturation following the administration of magnesium sulfate. A chest radiograph taken at bedside showed widespread interstitial shadowing&nbs
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14

Pajk, Werner, Birgit Schwarz, Hans Knotzer, et al. "Jejunal tissue oxygenation and microvascular flow motion during hemorrhage and resuscitation." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 6 (2002): H2511—H2517. http://dx.doi.org/10.1152/ajpheart.00222.2002.

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Анотація:
The relationship between flow motion and tissue oxygenation was investigated during hemorrhage/retransfusion with and without dopamine in 14 pigs. During 45% bleed, jejunal microvascular hemoglobin O2saturation (HBjO2) and mucosal tissue Po2(Po2muc) were recorded in seven control and seven dopamine-treated animals. Mean arterial pressure and systemic O2delivery decreased during hemorrhage and returned to baseline after retransfusion. Hemorrhage decreased Po2mucfrom 33 ± 2.8 to 13 ± 1.6 mmHg and HBjO2from 53 ± 4.9% to 32 ± 3.9%, respectively, in control animals. During reperfusion, Po2mucand HB
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15

Crisostomo, Isabel, Adel Zayyad, David W. Carley, et al. "Chemo- and baroresponses differ in African-Americans and Caucasians in sleep." Journal of Applied Physiology 85, no. 4 (1998): 1413–20. http://dx.doi.org/10.1152/jappl.1998.85.4.1413.

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Анотація:
To determine sleep effects on baro- and ventilatory responses to transient chemo- and barostimulation in African-Americans and Caucasians, 26 nonobese normotensive young subjects (13 African-Americans and 13 Caucasians) were studied awake and in non-rapid-eye movement (NREM) and rapid-eye-movement sleep during induced transient hypoxemia (N2), hypertension (phenylephrine, PE), and concomitant hypoxemia and hypertension (N2 + PE). Arterial blood pressure was recorded by plethysmographic volume clamp, minute ventilation by pneumotachograph, and arterial O2saturation by pulse oximeter. For all su
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16

Moss, Timothy J., and Richard Harding. "Ventilatory and arousal responses of sleeping lambs to respiratory challenges: effect of prenatal maternal anemia." Journal of Applied Physiology 88, no. 2 (2000): 641–48. http://dx.doi.org/10.1152/jappl.2000.88.2.641.

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Анотація:
We have examined the effects of exposure to chronic maternal anemia, throughout the final one-third of gestation, on postnatal ventilatory and arousal responses to hypoxia, hypercapnia, and combined hypoxia-hypercapnia in sleeping lambs. While resting quietly awake, lambs from anemic ewes had higher arterial [Formula: see text] levels than control animals during the first 2–3 postnatal wk, but pH, arterial [Formula: see text], and arterial O2 saturation were not different. During active and quiet sleep lambs from anemic ewes had higher end-tidal CO2levels than control animals when breathing ro
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17

Muzyamba, M. C., P. F. Speake, and J. S. Gibson. "Oxidants and regulation of K+-Cl−cotransport in equine red blood cells." American Journal of Physiology-Cell Physiology 279, no. 4 (2000): C981—C989. http://dx.doi.org/10.1152/ajpcell.2000.279.4.c981.

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Анотація:
The effect of oxidants on K+-Cl−cotransport (KCC) was investigated in equine red blood cells. Carbon monoxide mimicked O2. The substituted benzaldehyde, 12C79 (5 mM), markedly increased O2affinity. In N2, however, O2saturation was low (<10%) but KCC remained active. Nitrite (NO2−) oxidized heme to methemoglobin (metHb). High concentrations of NO2−(1 and 5 mM vs. 0.5 mM) increased KCC activity above control levels; it became O2independent but remained sensitive to other stimuli. 1-Chloro-2,4-dinitrobenzene (1–3 mM) depleted reduced glutathione (GSH). Prolonged exposure (60–120 min, 1 mM) or
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18

Soomro, Niaz Hussain Soomro, Hamid Mehmood, M. Aleemud Din, Aneeqa Ahsan Zafar, and Sadaf Siddiqui. "THORACIC EPIDURAL ANALGESIA." Professional Medical Journal 23, no. 08 (2016): 975–79. http://dx.doi.org/10.29309/tpmj/2016.23.08.1672.

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Анотація:
Objectives: The aim of this study is to determine whether thoracic epiduralanalgesia with bupivacaine is better than intravenous narcotic analgesia for pain relief inthoracotomy patients. Study design: Prospective randomized study. Setting: Department ofThoracic Surgery, Ojha Institute of Chest Diseases and Dow University of Health Sciences.Period: May 2014- Nov 2015. Methods: 144 patients were allocated randomly into 2 Groups.Group A received thoracic epidural analgesia with bupivacaine and Group B received intravenousnarcotic analgesia with tramadol. Pain was monitored in both groups using t
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19

Srinivasan, Ganesh, Eugene N. Bruce, Pamela K. Houtz, and Margaret C. Bruce. "Dexamethasone-induced changes in lung function are not prevented by concomitant treatment with retinoic acid." American Journal of Physiology-Lung Cellular and Molecular Physiology 283, no. 2 (2002): L275—L287. http://dx.doi.org/10.1152/ajplung.00423.2001.

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Анотація:
Alveolarization is impaired in rats treated with dexamethasone (Dex) on postnatal days 4–13, but concomitant treatment with all- trans retinoic acid (RA) increases alveolar number. To determine whether morphological changes induced by Dex and/or RA predict changes in lung function at 1 mo, we assessed resting breathing parameters, dynamic compliance, ventilation required to maintain O2 saturation at ≥90%, and pressure-volume curves of air-filled lungs. During resting breathing, mean tidal volume per gram was greater in Dex + RA-treated rats than in controls ( P < 0.05). Dynamic compliance w
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20

Honda, Y., H. Tani, A. Masuda, et al. "Effect of prior O2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans." Journal of Applied Physiology 81, no. 4 (1996): 1627–32. http://dx.doi.org/10.1152/jappl.1996.81.4.1627.

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Анотація:
Honda, Y., H. Tani, A. Masuda, T. Kobayashi, T. Nishino, H. Kimura, S. Masuyama, and T. Kuriyama. Effect of prior O2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans. J. Appl. Physiol. 81(4): 1627–1632, 1996.—Sixteen healthy volunteers breathed 100% O2 or room air for 10 min in random order, then their ventilatory response to sustained normocapnic hypoxia (80% arterial O2saturation, as measured with a pulse oximeter) was studied for 20 min. In addition, to detect agents possibly responsible for the respiratory changes, blood plasma of 10 of the 16 subjects was c
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21

Choi, Eun-Su, Jae-Hun Kim, Nam-Su Gil, et al. "Perioperative cerebral infarct during cardiac surgery and changes in jugular venous O2saturation and cerebral oximetry using near-infrared spectroscopy - A case report -." Korean Journal of Anesthesiology 56, no. 1 (2009): 102. http://dx.doi.org/10.4097/kjae.2009.56.1.102.

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22

Maryam, Yaghoubi Shahram Baraz* Mohammad Adineh Mohammad Hossain Haghighi zadeh. "THE EFFECT OF EXPIRATORY MANUAL RIB CAGE COMPRESSION BEFORE SUCTIONING ON BLOOD OXYGEN SATURATION IN PATIENTS." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4023–26. https://doi.org/10.5281/zenodo.1045212.

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Анотація:
Introduction: One of the most common ways put into practice to the clearance of the airway of patients who are under mechanical ventilation is applying suctioning into trachea. Some physiotherapeutic procedures including rib cage compression parallel to exhale and prior to suctioning can facilitate the egression of discharges. The present study aimed to determine the effect of rib cage compression during the exhale before suctioning on O2 saturation changes in patients receiving mechanical ventilation. Methodology: The research is a clinical trial study. The sample involved 55 patients who rec
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23

Carvalho, Clarissa Gutiérrez, Renato Soibelmann Procianoy, Eurico Camargo Neto, and Rita C. Silveira. "Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress." Journal of Immunology Research 2018 (2018): 1–4. http://dx.doi.org/10.1155/2018/6963754.

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Анотація:
Ventilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied. Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1β, IL-10, and IL-8 and TNF-αin preterm newborns under mechanical ventilation (MV) in their first two days.Methods. Prospective cohort including neonates with severe respiratory distress. Blood samples were collected right before and 2 hours after invasive MV. For analys
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24

Rurak, Dan, and Natalee W. Bessette. "Changes in fetal lamb arterial blood gas and acid-base status with advancing gestation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 304, no. 10 (2013): R908—R916. http://dx.doi.org/10.1152/ajpregu.00430.2012.

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Анотація:
To determine whether there are changes in blood gas and acid-base status with advancing gestation in the fetal lamb, similar to that reported in the human fetus, blood gas, acid-base, and blood metabolite values were measured in 447 control, arterial blood samples from 108 chronically instrumented fetal lambs between 103 and 146 days gestation. With advancing gestation, Po2, pH, O2saturation, and O2content fell significantly, while Pco2and hemoglobin concentration increased. Blood glucose and lactate concentrations were unchanged, although the lactate level increased with decreasing Po2, parti
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25

Van Mil, Annette H. M., Aart Spilt, Mark A. Van Buchem, et al. "Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans." Journal of Applied Physiology 92, no. 3 (2002): 962–66. http://dx.doi.org/10.1152/japplphysiol.00616.2001.

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Анотація:
Nitric oxide (NO) plays a pivotal role in the regulation of peripheral vascular tone. Its role in the regulation of cerebral vascular tone in humans remains to be elucidated. This study investigates the role of NO in hypoxia-induced cerebral vasodilatation in young healthy volunteers. The effect of the NO synthase inhibitor N G-monomethyl-l-arginine (l-NMMA) on the cerebral blood flow (CBF) was assessed during normoxia and during hypoxia (peripheral O2saturation 97 and 80%, respectively). Subjects were positioned in a magnetic resonance scanner, breathing normal air (normoxia) or a N2-O2 mixtu
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26

Takamura, Masayuki, Robert Parent, Peter Cernacek, and Michel Lavallée. "Influence of dual ETA/ETB-receptor blockade on coronary responses to treadmill exercise in dogs." Journal of Applied Physiology 89, no. 5 (2000): 2041–48. http://dx.doi.org/10.1152/jappl.2000.89.5.2041.

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Анотація:
We hypothesized that endothelin (ET) release during exercise may be triggered by α-adrenergic-receptor activation and thereby influence coronary hemodynamics and O2 metabolism in dogs. Exercise resulted in coronary blood flow increases (to 1.88 ± 0.26 from 1.10 ± 0.12 ml · min−1 · g−1) and in a fall ( P < 0.01) in coronary sinus O2saturation (17.4 ± 1.5 to 9.6 ± 0.7 vol%), whereas myocardial O2 consumption (MV˙o 2) increased (109 ± 13% from 145 ± 16 μl O2 · min−1 · g−1). Tezosentan, a dual ETA/ETB-receptor blocker, slightly reduced mean arterial pressure (MAP) and increased heart rate throu
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27

Zhang, Haibo, Giuliana Porro, Neil Orzech, Brendan Mullen, Mingyao Liu, and Arthur S. Slutsky. "Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 5 (2001): L947—L954. http://dx.doi.org/10.1152/ajplung.2001.280.5.l947.

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Анотація:
High concentrations of neutrophil defensins from airway and blood have been reported in patients with inflammatory lung diseases, but their exact role is unclear. We investigated the direct effect of defensins on the lungs of mice. Intratracheal instillation of purified defensins (5–30 mg/kg) induced a progressive reduction in peripheral arterial O2saturation, increased lung permeability, and enhanced the lung cytochrome c content. These indexes of acute lung dysfunction were associated with an increased total cell number and a significant neutrophil influx into the lung [5.1 ± 0.04% in contro
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28

Tzadok, Tomer, Ronen Toledano, Lior Fuchs, Carmi Bartal, Victor Novack, and Gal Ifergane. "Headache in the presentation of noncephalic acute illness." Journal of Neurosciences in Rural Practice 06, no. 04 (2015): 494–98. http://dx.doi.org/10.4103/0976-3147.168425.

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Анотація:
ABSTRACT Background: Headache is a frequent symptom of many systemic diseases that do not involve cranial structures. In this observational study, we assessed factors associated with headache in the acute presentation of systemic conditions in a nonsurgical emergency department (ED). Methods: Consecutive patients, admitted to Soroka University Medical Center ED due to noncephalic illness, were prospectively surveyed using a structured questionnaire focused on the prevalence and characteristics of headache symptoms. Medical data were extracted from the patient's charts. Results: Between 1 and 6
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29

Vargas, Marco, Enrique Vargas, Colleen G. Julian, et al. "Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, no. 3 (2007): R1303—R1312. http://dx.doi.org/10.1152/ajpregu.00805.2006.

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Анотація:
High altitude decreases birth weight, but this effect is diminished in long vs. short-resident, high-altitude populations. We asked whether women from long vs. short-resident, high-altitude populations had higher arterial oxygenation levels by comparing 42 Andean and 26 European residents of La Paz, Bolivia (3,600 m), serially during pregnancy ( weeks 20, 30, and 36) and again 4 mo postpartum. Pregnancy raised hypoxic ventilatory sensitivity threefold, resting ventilation (V̇e), and arterial O2saturation (SaO2) in both groups. Ancestry, as identified using 81 genetic markers, correlated with r
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30

Nielsen, H. B., R. Boushel, P. Madsen, and N. H. Secher. "Cerebral desaturation during exercise reversed by O2 supplementation." American Journal of Physiology-Heart and Circulatory Physiology 277, no. 3 (1999): H1045—H1052. http://dx.doi.org/10.1152/ajpheart.1999.277.3.h1045.

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Анотація:
The combined effects of hyperventilation and arterial desaturation on cerebral oxygenation ([Formula: see text]) were determined using near-infrared spectroscopy. Eleven competitive oarsmen were evaluated during a 6-min maximal ergometer row. The study was randomized in a double-blind fashion with an inspired O2 fraction of 0.21 or 0.30 in a crossover design. During exercise with an inspired O2 fraction of 0.21, the arterial CO2 pressure (35 ± 1 mmHg; mean ± SE) and O2 pressure (77 ± 2 mmHg) as well as the hemoglobin saturation (91.9 ± 0.7%) were reduced ( P < 0.05).[Formula: see text] was
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31

Villafuerte, Francisco C., José Luis Macarlupú, Cecilia Anza-Ramírez, et al. "Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness." Journal of Applied Physiology 117, no. 11 (2014): 1356–62. http://dx.doi.org/10.1152/japplphysiol.00619.2014.

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Анотація:
Excessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having altitude-normal blood erythropoietin (Epo) concentration is still unclear. A soluble form of the Epo receptor (sEpoR) has been identified in human blood and competes directly for Epo with its membrane counterpart (mEpoR). Thus, reduced levels of circulating sEpoR could lead to higher Epo availability and ultimately to EE. We characterized the relationship
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32

Hsia, Connie C. W., Robert L. Johnson, Eugene Y. Wu, Aaron S. Estrera, Harrieth Wagner, and Peter D. Wagner. "Reducing lung strain after pneumonectomy impairs oxygen diffusing capacity but not ventilation-perfusion matching." Journal of Applied Physiology 95, no. 4 (2003): 1370–78. http://dx.doi.org/10.1152/japplphysiol.00338.2003.

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Анотація:
After pneumonectomy (Pnx), mechanical strain on the remaining lung is an important signal for adaptation. To examine how mechanical lung strain alters gas exchange adaptation after Pnx, we replaced the right lung of adult dogs with a custom-shaped inflatable silicone prosthesis. The prosthesis was kept 1) inflated (Inf) to reduce mechanical strain of the remaining lung and maintain the mediastinum in the midline, or 2) deflated (Def) to allow lung strain and mediastinal shift. Gas exchange was studied 4-7 mo later at rest and during treadmill exercise by the multiple inert gas elimination tech
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33

Arabi, Yaseen, Barbara J. Morgan, Brian Goodman, Dominic S. Puleo, Ailiang Xie, and James B. Skatrud. "Daytime blood pressure elevation after nocturnal hypoxia." Journal of Applied Physiology 87, no. 2 (1999): 689–98. http://dx.doi.org/10.1152/jappl.1999.87.2.689.

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Анотація:
The purpose of this study was to investigate whether nocturnal hypoxia causes daytime blood pressure (BP) elevation. We hypothesized that overnight exposure to hypoxia leads the next morning to elevation in BP that outlasts the hypoxia stimulus. We studied the effect on BP of two consecutive night exposures to hypobaric hypoxia in 10 healthy normotensive subjects. During the hypoxia nights, subjects slept for 8 h in a hypobaric chamber at a simulated altitude of 4,000 m (barometric pressure = 462 mmHg). Arterial O2saturation and electrocardiogram were monitored throughout the night. For 30 min
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34

Alecsandru, Diana, Israel Gestoso, Ana Romero, et al. "E. coliMultiresistant Meningitis after Transrectal Prostate Biopsy." Scientific World JOURNAL 6 (2006): 2323–26. http://dx.doi.org/10.1100/tsw.2006.362.

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Анотація:
Escherichia colimeningitis is a frequent pathology in children younger than 3 years old, but is an uncommon disease in adults.E. coliinfection is the main cause of intrahospital bacteremia as a consequence of the employment of different medical procedures. Our patient, male, 69 years old, presented with fever, progressive difficulty in breathing, and shivers 24 h after transrectal prostate biopsy, with an absence of any other symptoms. He received prophylactic treatment with ciprofloxacin and later empirical treatment with ampicillin and tobramicin. After that, the patient presented with fever
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35

Brutsaert, Tom D., Esteban J. Parra, Mark D. Shriver, et al. "Spanish genetic admixture is associated with larger V̇o2 maxdecrement from sea level to 4,338 m in Peruvian Quechua." Journal of Applied Physiology 95, no. 2 (2003): 519–28. http://dx.doi.org/10.1152/japplphysiol.01088.2002.

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Анотація:
Quechua in the Andes may be genetically adapted to altitude and able to resist decrements in maximal O2consumption in hypoxia (ΔV̇o2 max). This hypothesis was tested via repeated measures of V̇o2 max(sea level vs. 4,338 m) in 30 men of mixed Spanish and Quechua origins. Individual genetic admixture level (%Spanish ancestry) was estimated by using ancestry-informative DNA markers. Genetic admixture explained a significant proportion of the variability in ΔV̇o2 maxafter control for covariate effects, including sea level V̇o2 maxand the decrement in arterial O2saturation measured at V̇o2 max(ΔSpO
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36

Ulatowski, John A., Enrico Bucci, Anna Razynska, Richard J. Traystman, and Raymond C. Koehler. "Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 6 (1998): H1933—H1942. http://dx.doi.org/10.1152/ajpheart.1998.274.6.h1933.

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Анотація:
We determined whether cerebral blood flow (CBF) remained related to arterial O2 content ([Formula: see text]) during hypoxic hypoxia when hematocrit and hemoglobin concentration were independently varied with cell-free, tetramerically stabilized hemoglobin transfusion. Three groups of pentobarbital sodium-anesthetized cats were studied with graded reductions in arterial O2saturation to 50%: 1) a control group with a hematocrit of 31 ± 1% (mean ± SE; n = 7); 2) an anemia group with a hematocrit of 21 ± 1% that underwent an isovolumic exchange transfusion with an albumin solution ( n = 8); and 3
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37

Chowdhuri, Susmita, Sukanya Pranathiageswaran, Rene Franco-Elizondo, et al. "Effect of age on long-term facilitation and chemosensitivity during NREM sleep." Journal of Applied Physiology 119, no. 10 (2015): 1088–96. http://dx.doi.org/10.1152/japplphysiol.00030.2015.

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Анотація:
The reason for increased sleep-disordered breathing with a predominance of central apneas in the elderly is unknown. We speculate that ventilatory control instability may provide a link between aging and the onset of unstable breathing during sleep. We sought to investigate potential underlying mechanisms in healthy, elderly adults during sleep. We hypothesized that there is 1) a decline in respiratory plasticity or long-term facilitation (LTF) of ventilation and/or 2) increased ventilatory chemosensitivity in older adults during non-, this should be hyphenated, non-rapid rapid eye movement (N
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38

Brutsaert, Tom D., Esteban J. Parra, Mark D. Shriver, Alfredo Gamboa, Maria Rivera-Ch, and Fabiola León-Velarde. "Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 289, no. 1 (2005): R225—R234. http://dx.doi.org/10.1152/ajpregu.00105.2005.

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Анотація:
Andean high-altitude (HA) natives have a low (blunted) hypoxic ventilatory response (HVR), lower effective alveolar ventilation, and lower ventilation (VE) at rest and during exercise compared with acclimatized newcomers to HA. Despite blunted chemosensitivity and hypoventilation, Andeans maintain comparable arterial O2saturation (SaO2). This study was designed to evaluate the influence of ancestry on these trait differences. At sea level, we measured the HVR in both acute (HVR-A) and sustained (HVR-S) hypoxia in a sample of 32 male Peruvians of mainly Quechua and Spanish origins who were born
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39

Chen, Qiu-Hong, Ri-Li Ge, Xiao-Zhen Wang, et al. "Exercise performance of Tibetan and Han adolescents at altitudes of 3,417 and 4,300 m." Journal of Applied Physiology 83, no. 2 (1997): 661–67. http://dx.doi.org/10.1152/jappl.1997.83.2.661.

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Анотація:
Chen, Qiu-Hong, Ri-Li Ge, Xiao-Zhen Wang, Hui-Xin Chen, Tian-Yi Wu, Toshio Kobayashi, and Kazuhiko Yoshimura. Exercise performance of Tibetan and Han adolescents at altitudes of 3,417 and 4,300 m. J. Appl. Physiol. 83(2): 661–667, 1997.—The difference was studied between O2 transport in lifelong Tibetan adolescents and in newcomer Han adolescents acclimatized to high altitude. We measured minute ventilation, maximal O2 uptake, maximal cardiac output, and arterial O2 saturation during maximal exercise, using the incremental exercise technique, at altitudes of 3,417 and 4,300 m. The groups were
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40

Ge, Ri-Li, S. Witkowski, Y. Zhang, et al. "Determinants of erythropoietin release in response to short-term hypobaric hypoxia." Journal of Applied Physiology 92, no. 6 (2002): 2361–67. http://dx.doi.org/10.1152/japplphysiol.00684.2001.

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Анотація:
We measured blood erythropoietin (EPO) concentration, arterial O2saturation (SaO2), and urine Po2in 48 subjects (32 men and 16 women) at sea level and after 6 and 24 h at simulated altitudes of 1,780, 2,085, 2,454, and 2,800 m. Renal blood flow (Doppler) and Hb were determined at sea level and after 6 h at each altitude ( n = 24) to calculate renal O2delivery. EPO increased significantly after 6 h at all altitudes and continued to increase after 24 h at 2,454 and 2,800 m, although not at 1,780 or 2,085 m. The increase in EPO varied markedly among individuals, ranging from −41 to 400% after 24
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41

Shoemaker, J. Kevin, Allen R. Kunselman, David H. Silber, and Lawrence I. Sinoway. "Maintained exercise pressor response in heart failure." Journal of Applied Physiology 85, no. 5 (1998): 1793–99. http://dx.doi.org/10.1152/jappl.1998.85.5.1793.

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Анотація:
The impact of forearm blood flow limitation on muscle reflex (metaboreflex) activation during exercise was examined in 10 heart failure (HF) (NYHA class III and IV) and 9 control (Ctl) subjects. Rhythmic handgrip contractions (25% maximal voluntary contraction, 30 contractions/min) were performed over 5 min under conditions of ambient pressure or with +50 mmHg positive pressure about the exercising forearm. Mean arterial blood pressure (MAP) and venous effluent hemoglobin (Hb) O2 saturation, lactate and H+ concentrations ([La] and [H+], respectively) were measured at baseline and during exerci
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42

Wetter, Thomas J., Claudette M. St. Croix, David F. Pegelow, David A. Sonetti, and Jerome A. Dempsey. "Effects of exhaustive endurance exercise on pulmonary gas exchange and airway function in women." Journal of Applied Physiology 91, no. 2 (2001): 847–58. http://dx.doi.org/10.1152/jappl.2001.91.2.847.

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Анотація:
Seventeen fit women ran to exhaustion (14 ± 4 min) at a constant speed and grade, reaching 95 ± 3% of maximal O2 consumption. Pre- and postexercise lung function, including airway resistance [total respiratory resistance (Rrs)] across a range of oscillation frequencies, was measured, and, on a separate day, airway reactivity was assessed via methacholine challenge. Arterial O2saturation decreased from 97.6 ± 0.5% at rest to 95.1 ± 1.9% at 1 min and to 92.5 ± 2.6% at exhaustion. Alveolar-arterial O2 difference (A-aDo 2) widened to 27 ± 7 Torr after 1 min and was maintained at this level until e
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43

Fernandes, Julia Freitas Rodrigues, Luciene da Silva Araújo, Sergio Emanuel Kaiser, Antonio Felipe Sanjuliani, and Márcia Regina Simas Torres Klein. "The effects of moderate energy restriction on apnoea severity and CVD risk factors in obese patients with obstructive sleep apnoea." British Journal of Nutrition 114, no. 12 (2015): 2022–31. http://dx.doi.org/10.1017/s0007114515004018.

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Анотація:
AbstractNutritional intervention for weight loss is one of the treatment options for obstructive sleep apnoea (OSA) in patients with overweight or obesity. However, the effects of moderate energy restriction on OSA severity are not yet known. The present study aimed to evaluate the effects of moderate energy restriction on OSA severity and CVD risk factors in obese patients with OSA. In this 16-week randomised clinical trial, twenty-one obese subjects aged 20–55 years and presenting an apnoea/hypopnoea index (AHI)≥5 events/h were randomised into two groups: the energy restriction group (ERG) a
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44

Deacon, Naomi L., R. Doug McEvoy, Daniel L. Stadler, and Peter G. Catcheside. "Intermittent hypercapnic hypoxia during sleep does not induce ventilatory long-term facilitation in healthy males." Journal of Applied Physiology 123, no. 3 (2017): 534–43. http://dx.doi.org/10.1152/japplphysiol.01005.2016.

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Анотація:
Intermittent hypoxia-induced ventilatory neuroplasticity is likely important in obstructive sleep apnea pathophysiology. Although concomitant CO2levels and arousal state critically influence neuroplastic effects of intermittent hypoxia, no studies have investigated intermittent hypercapnic hypoxia effects during sleep in humans. Thus the purpose of this study was to investigate if intermittent hypercapnic hypoxia during sleep induces neuroplasticity (ventilatory long-term facilitation and increased chemoreflex responsiveness) in humans. Twelve healthy males were exposed to intermittent hyperca
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45

Modanlou, Houchang D., and Kay Beharry. "Biochemical and molecular endothelin responses to morphine sulfate infusion in conscious newborn piglets." Canadian Journal of Physiology and Pharmacology 76, no. 4 (1998): 443–50. http://dx.doi.org/10.1139/y98-034.

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Анотація:
The biochemical and molecular endothelin-1 (ET-1)responses to high dose morphine sulfate infusion were studied in conscious newborn piglets(n = 6) that received a loading dose of 100 µg/kg over 5 min followed by acontinuous i.v. infusion dose of 100 µg·kg–1·h–1 for 4 h. The controlgroup (n = 6) received equivalent volume loading and infusion doses of 5% dextrose.Blood samples were drawn serially from the femoral artery and sagittal sinus vein before (0),during (30 min, 1, 2, 3, and 4 h), and post (1 and 2 h) infusion. Five micrograms oftotal RNA obtained from brainstem tissue homogenates was a
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46

Wang, Winfred C., Molly Beth Freeman, Yvonne M. Carroll, et al. "High Failure Rate with Brigance Developmental Screening in 3 Year-Old Children with Sickle Cell Disease." Blood 124, no. 21 (2014): 4926. http://dx.doi.org/10.1182/blood.v124.21.4926.4926.

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Abstract Background: Central nervous system complications of sickle cell disease (SCD) include stroke, silent cerebral infarct, and neurocognitive deficits, but few studies have examined developmental delays in preschool-age children. Using the Brigance developmental screen in 3 year-old children with SCD we found a high frequency of scores below the “normal” cutoff for age, but control data were lacking (Ped. Blood Cancer 2011;56:620). We hypothesized that children with SCD would be more likely to “fail” this screening test than age-matched children from a similar ethnic/socio-economic backgr
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47

Delmastro, M., C. Santoro, and S. Nava. "Respiratory changes during defecation in patients with chronic respiratory failure." March 24, 2004. https://doi.org/10.1183/09031936.04.00084504.

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Анотація:
Oxygen (O2) desaturation may occur in patients affected by respiratory diseases during daily activities, although most of these activities,e.g.walking, washing and cooking, can be avoided or eventually performed with an external aid.In this prospective study, the respiratory changes induced by the mandatory effort of defecation were assessed in patients with chronic respiratory insufficiency. Twenty-four consecutive patients with chronic respiratory failure due to obstructive or restrictive pulmonary disorders, showing a marked O2desaturation during the 6-min walk test, were enrolled. Thirteen
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48

Griese, Matthias, Nicolaus Schwerk, Julia Carlens, et al. "Minimal important difference in childhood interstitial lung diseases." Thorax, December 26, 2022, thoraxjnl—2022–219206. http://dx.doi.org/10.1136/thorax-2022-219206.

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Анотація:
BackgroundMonitoring disease progression in childhood interstitial lung diseases (chILD) is essential. No information for the minimal important difference (MID), which is defined as the smallest change in a parameter that is perceived as important prompting a clinician to change the treatment, is available. We calculated MIDs for vital signs (respiratory rate, peripheral oxygen saturation in room air, Fan severity score) and health-related quality of life (HrQoL) scores.MethodsThis study used data from the Kids Lung Register, which is a web-based management platform that collects data of rare
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49

Langer, Christine, Claus Wittekindt, Christoph Arens, and Sonja Käbisch. "Apnoeic oxygenation with high flow nasal oxygen for interventional surgery of the larynx and pharynx." European Archives of Oto-Rhino-Laryngology, May 16, 2024. http://dx.doi.org/10.1007/s00405-024-08726-6.

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Анотація:
Abstract Background Highflow nasal cannula oxygen (HFNO) is known to be used for noninvasive oxygenation in intensive care patients but it has rarely been used in airway management for elective surgery of the upper aerodigestive tract. Objectives HFNO offers opportunities of a tubeless oxygenation system which is easy to handle and not limited only on surgery of the endolarynx. Methods We evaluated this method for oxygenation during brief interventional procedures of the larynx and pharynx in 92 adult patients for safety and intraoperative complications. The need of secondary endotracheal intu
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50

Pereira da Silva Carpeggiani, Fernanda, Thiago Menezes Cézar, Tatiana Schäffer Gregianini, Felipe Grillo Pinheiro, Letícia Garay Martins, and Ana Beatriz Gorini da Veiga. "Impact of COVID-19 on the epidemiology of respiratory viruses in southern Brazil." Revista de Epidemiologia e Controle de Infecção 14, no. 2 (2024). http://dx.doi.org/10.17058/reci.v14i2.18935.

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Анотація:
Background and objectives: During the SARS-CoV-2 pandemic, reduction in detection of other Respiratory Viruses (RV) was observed. Epidemiological studies are needed to understand the impact of the pandemic on the circulation of RV. The aim of this study is to analyze the epidemiological profile of cases of severe acute respiratory infection (SARI) associated with the main RV in hospitalized patients from RS, between 2010 and 2019 (period A) and between 2020 and 2021 (period B). Methods: Data related to SARI cases in RS were retrieved from SIVEP-Gripe. Results: In period A there were more infec
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