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Статті в журналах з теми "OA knee"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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1

JONES, RICHARD K., GRAHAM J. CHAPMAN, ANDREW H. FINDLOW, et al. "A New Approach to Prevention of Knee Osteoarthritis: Reducing Medial Load in the Contralateral Knee." Journal of Rheumatology 40, no. 3 (2013): 309–15. http://dx.doi.org/10.3899/jrheum.120589.

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Objective.Few if any prevention strategies are available for knee osteoarthritis (OA). In those with symptomatic medial OA, the contralateral knee may be at high risk of disease, and a reduction in medial loading in that knee might prevent disease or its progression there. Our aim was to determine how often persons with medial OA on 1 side had either concurrent or later medial OA on the contralateral side, and whether an intervention known to reduce medial loading in affected knees with medial OA might reduce medial loading in the contralateral knee. Lateral wedge insoles reduce loading across

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2

Driban, Jeffrey B., Easwaran Balasubramanian, Mamta Amin, Michael R. Sitler, Marvin C. Ziskin, and Mary F. Barbe. "The Potential of Multiple Synovial-Fluid Protein-Concentration Analyses in the Assessment of Knee Osteoarthritis." Journal of Sport Rehabilitation 19, no. 4 (2010): 411–21. http://dx.doi.org/10.1123/jsr.19.4.411.

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Context:Joint trauma is a risk factor for osteoarthritis (OA), which is becoming an increasingly important orthopedic concern for athletes and nonathletes alike. For advances in OA prevention, diagnosis, and treatment to occur, a greater understanding of the biochemical environment of the affected joint is needed.Objective:To demonstrate the potential of a biochemical technique to enhance our understanding of and diagnostic capabilities for osteoarthritis.Design:Cross-sectional.Setting:Outpatient orthopedic practice.Participants:8 subjects: 4 OA-knee participants (65 ± 6 y of age) and 4 normal

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3

Smith, Matthew V., Jeffrey J. Nepple, Rick W. Wright, Matthew J. Matava, and Robert H. Brophy. "Knee Osteoarthritis Is Associated With Previous Meniscus and Anterior Cruciate Ligament Surgery Among Elite College American Football Athletes." Sports Health: A Multidisciplinary Approach 9, no. 3 (2016): 247–51. http://dx.doi.org/10.1177/1941738116683146.

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Background: Football puts athletes at risk for knee injuries such meniscus and anterior cruciate ligament (ACL) tears, which are associated with the development of osteoarthritis (OA). Previous knee surgery, player position, and body mass index (BMI) may be associated with knee OA. Hypothesis: In elite football players undergoing knee magnetic resonance imaging at the National Football League’s Invitational Combine, the prevalence of knee OA is associated with previous knee surgery and BMI. Study Design: Retrospective cohort. Level of Evidence: Level 4. Methods: A retrospective review was perf

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4

Hamai, Satoshi, Ken Okazaki, Satoru Ikebe, et al. "In Vivo Kinematics of Healthy and Osteoarthritic Knees During Stepping Using Density-Based Image-Matching Techniques." Journal of Applied Biomechanics 32, no. 6 (2016): 586–92. http://dx.doi.org/10.1123/jab.2016-0112.

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The purpose of this study was to investigate in vivo kinematics in healthy and osteoarthritic (OA) knees during stepping using image-matching techniques. Six healthy volunteers and 14 patients with a medial OA knee before undergoing total knee arthroplasty performed stepping under periodic anteroposterior radiograph images. We analyzed the three-dimensional kinematic parameters of knee joints using radiograph images and CT-derived digitally reconstructed radiographs. The average extension/flexion angle ranged 6°/53° and 16°/44° in healthy and OA knees, with significant difference in extension

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5

Budhiparama, Nicolaas C., Imelda Lumban-Gaol, Herawati Sudoyo, Rahadyan Magetsari, and Tri Wibawa. "Interleukin-1 genetic polymorphisms in knee osteoarthritis: What do we know? A meta-analysis and systematic review." Journal of Orthopaedic Surgery 30, no. 1 (2022): 230949902210766. http://dx.doi.org/10.1177/23094990221076652.

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Purpose Interleukin-1 is the main proinflammatory cytokine in osteoarthritis (OA). Several single-nucleotide polymorphisms (SNPs) within the IL-1 gene cluster (IL-1β, IL-1R1, and IL-1RN) have been determined, but their associations with knee OA remain poorly understood. The present study aimed to identify the associations between IL-1 SNPs and knee osteoarthritis. Methods This meta-analysis and systematic review included all comparative studies published in the MEDLINE/PubMed, Embase, Google Scholar, and Cochrane Library databases. We performed a systematic search to identify relevant studies

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6

Bastick, Alex N., Jurgen Damen, Rintje Agricola, Reinoud W. Brouwer, Patrick JE Bindels, and Sita MA Bierma-Zeinstra. "Characteristics associated with joint replacement in early symptomatic knee or hip osteoarthritis: 6-year results from a nationwide prospective cohort study (CHECK)." British Journal of General Practice 67, no. 663 (2017): e724-e731. http://dx.doi.org/10.3399/bjgp17x692165.

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BackgroundMany patients with osteoarthritis (OA) of the knee and/or hip undergo total joint replacement (TJR) because of severely progressed symptoms.AimTo determine patient and disease characteristics associated with undergoing TJR in participants with recent-onset knee and/or hip OA.Design and settingParticipants with hip or knee pain from the nationwide prospective Cohort Hip and Cohort Knee (CHECK) study were included.MethodThe outcome measure was total hip arthroplasty (THA) or total knee arthroplasty (TKA) during 6 years of follow-up. Joint-dependent characteristics were compared using g

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7

Naredo, Esperanza. "Ultrasonographic findings in knee osteoarthritis: a comparative study with clinical and radiographic assessment." Osteoarthritis Cartilage 13, no. 7 (2005): 568–74. https://doi.org/10.1016/j.joca.2005.02.008.

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Objective: To compare ultrasonographic (US) findings with clinical and radiographic assessment in knee osteoarthritis (OA). Methods: Fifty patients with primary knee OA were studied. Clinical assessment of both knees was performed by the same rheumatologist who recorded a visual analogue scale (VAS) for pain (VASP). All patients underwent a US examination of their knees by a second blinded rheumatologist. Weight-bearing anteroposterior and lateral knee radiographs were read by a third blinded rheumatologist who assessed the Kellgren and Lawrence (K-L) grade, the femorotibial (FT) spa

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8

Tanaka, Noriyuki, and Minoru Hoshiyama. "ARTICULAR SOUND AND CLINICAL STAGES IN KNEE ARTHROPATHY." Journal of Musculoskeletal Research 14, no. 01 (2011): 1150006. http://dx.doi.org/10.1142/s0218957711500060.

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Objective: To clarify the pathophysiology of knee arthropathy, articular sound in the knee joint was recorded using an accelerometer, vibroarthrography (VAG), during standing-up and sitting-down movements in patients with osteoarthropathy (OA) of the knees. Methods: VAG signals and angular changes of the knee joint during standing-up and sitting-down movements were recorded in patients with OA, including 17 knees with OA at Kellgren–Lawrence stage I and II, 16 knees with OA at III and IV stages, and 20 knees of age-matched control subjects. Results: The level of VAG signals was greater in knee

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9

Auday Hussain Hassan Al-Janaby. "Knee osteoarthritis severity concerning neutrophil-lymphocyte ratio." Magna Scientia Advanced Research and Reviews 2, no. 2 (2021): 080–84. http://dx.doi.org/10.30574/msarr.2021.2.2.0054.

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Osteoarthritis (OA) is a disease with a significant inflammatory component. Neutrophil-lymphocyte ratio (NLR) level is a marker to determine inflammation. The study aimed to evaluate the association between the severity of knee OA and NLR. A case-control study was conducted in Al-Zahrawi from June 2017 to June 2018. A total of 100 knees OA were recruited and 50 healthy subjects as a control group. NLR was significantly higher in knee OA than controls, the mean value was (2.19±0.72) and (1.97±0.88), respectively. Older age, chronic pain, prolong the onset of diagnosis and high NLR were signific

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10

Linda Pertiwi, Ni Made, and Ni Luh Jaya Kirana. "Conventional Radiography of Grade III Knee Osteoarthritis: A Case Report." International Journal of Research and Review 10, no. 10 (2023): 536–40. http://dx.doi.org/10.52403/ijrr.20231068.

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Introduction: Osteoarthritis (OA) is the most common form of inflammatory joint disease. It occurs most frequently in the knees, hips, the spine (vertebrae), and ankles. Radiological prevalence of knee OA in Indonesia reaches 15.5% in men and 12.7% in women aged between 40-60 years. X-ray imaging is routinely used in clinical practice to confirm knee OA diagnosis and in clinical research to monitor the progression of knee OA. Case report: A 62-year-old female patient presented with knee pain in both knees that had been ongoing for the past 6 months. The pain was described as throbbing and stab

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11

Shirinsky, I., and V. Shirinsky. "FRI0422 HOW MANY OA PATIENTS WILL BE OVERTREATED IF TREATED WITH DMOADS? ANALYSIS OF OSTEOARTHRITIS INITIATIVE DATA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 809.1–809. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2277.

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Background:Significant research effort is currently put on discovering drugs able to slow structural progression of osteoarthritis (OA). In many patients OA shows little or no increase in pain or function deterioration over time. Thus, giving disease-modifying OA drugs (DMOAD) for long periods to this subset of patients can be considered as overtreatment. There is a lack of studies directly evaluating how many patients with diagnosed OA experience no impact of the disease during long-term follow up and thus probably do not need any disease modification.Objectives:To assess proportions of patie

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12

Brigham, Christopher R., Charles N. Brooks, and James B. Talmage. "Knee Osteoarthritis." Guides Newsletter 10, no. 2 (2005): 1–3. http://dx.doi.org/10.1001/amaguidesnewsletters.2005.marapr01.

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Abstract More than 20 million Americans have osteoarthritis (OA), which affects the knee more often than any other joint and is the most common cause of long-term disability in persons older than 65 years. Knee OA is common, particularly in older patients and especially the obese. Knee injury, depending on the severity and type, can increase the risk of developing and the rate of progression of OA. In assessing impairment for knee OA, the evaluator must obtain a thorough history and physical examination and identify all potential risk factors. To opine that an injury caused OA, the evaluator s

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13

Nevitt, M. C., Y. Zhang, M. K. Javaid, et al. "High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study." Annals of the Rheumatic Diseases 69, no. 01 (2009): 163–68. http://dx.doi.org/10.1136/ard.2008.099531.

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Objectives:Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident knee osteoarthritis (OA) defined by osteophytes but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. The association of BMD with incident and progressive tibiofemoral OA was tested in a large prospective study of men and women aged 50–79 years with or at risk for knee OA.Methods:Baseline and 30-month weight-bearing posteroanterior and lateral knee radiographs were scored for Kellgren-Lawrence (K-L) grade, JSN and osteophytes. Inci

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14

De Marziani, Luca, Angelo Boffa, Simone Orazi, et al. "Joint Response to Exercise Is Affected by Knee Osteoarthritis: An Infrared Thermography Analysis." Journal of Clinical Medicine 12, no. 10 (2023): 3399. http://dx.doi.org/10.3390/jcm12103399.

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Infrared thermography can be used to evaluate the inflammation characterizing the joint environment of OA knees, but there is limited evidence on the response to physical exercise. Identifying the response to exercise of OA knees and the influencing variables could provide important information to better profile patients with different knee OA patterns. Sixty consecutive patients (38 men/22 women, 61.4 ± 9.2 years) with symptomatic knee OA were enrolled. Patients were evaluated with a standardized protocol using a thermographic camera (FLIR-T1020) positioned at 1 m with image acquisition of an

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15

Gabriel, Stefan M., Anton G. Clifford, William J. Maloney, Mary K. O’Connell, and Paul Tornetta. "Unloading the Osteoarthritic Knee with a Novel Implant System." Journal of Applied Biomechanics 29, no. 6 (2013): 647–54. http://dx.doi.org/10.1123/jab.29.6.647.

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Medial knee osteoarthritis (OA) is a common disorder often associated with pathologic joint loading. Insoles, braces, and high tibial osteotomy are OA treatments aimed at reducing medial joint loads, but their use and effectiveness are limited. The KineSpring System implant also intends to reduce knee loads in OA patients while overcoming those limitations. The current study was undertaken to test the implant’s effect on loads at the knee. Six cadaver knees with Outerbridge Grade I-II medial OA were subjected to simulated gait using a kinematic test system. Knees were tested with and without t

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16

Guida, Carmine, Ming Zhang, and Juan Shan. "Knee Osteoarthritis Classification Using 3D CNN and MRI." Applied Sciences 11, no. 11 (2021): 5196. http://dx.doi.org/10.3390/app11115196.

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Osteoarthritis (OA) is the most common form of arthritis and can often occur in the knee. While convolutional neural networks (CNNs) have been widely used to study medical images, the application of a 3-dimensional (3D) CNN in knee OA diagnosis is limited. This study utilizes a 3D CNN model to analyze sequences of knee magnetic resonance (MR) images to perform knee OA classification. An advantage of using 3D CNNs is the ability to analyze the whole sequence of 3D MR images as a single unit as opposed to a traditional 2D CNN, which examines one image at a time. Therefore, 3D features could be e

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17

Chen, Tianwu, Shuang Wang, Yunxia Li, Chengchong Ai, Fangyi Jiang, and Shiyi Chen. "Radiographic Osteoarthritis Prevalence Over Ten Years After Anterior Cruciate Ligament Reconstruction." International Journal of Sports Medicine 40, no. 11 (2019): 683–95. http://dx.doi.org/10.1055/a-0902-8539.

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AbstractThe purpose of this study was to conduct an up-to-date systematic review and meta-analysis of radiographic knee osteoarthritis (OA) over minimal ten years after ACL reconstruction. The database of Pubmed and the Ovid was adopted. The radiographic knee OA over minimal ten years after ACL reconstruction was systematically reviewed. Both the ipsilateral and contralateral knees were evaluated referring to the tibiofemoral joint (TFJ), the patellofemoral joint (PFJ), and the overall knee OA prevalence. Nineteen studies were included for review, with nine screened for the meta-analysis. The

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18

Namirembe, Waldah, Joanita Namawejje, Wopotela D. Kisombo, and Ambrose Asiimwe. "KNOWLEDGE OF THE USE OF KNEE BRACES IN THE MANAGEMENT OF KNEE OSTEOARTHRITIS AMONG PATIENTS AGED 36 YEARS AND ABOVE IN MULAGO NATIONAL REFERRAL HOSPITAL. A CROSS-SECTIONAL STUDY." SJ Orthopaedic Research Africa 1, no. 8 (2024): 6. https://doi.org/10.51168/vsrew127.

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Background Patient education is an important first-line OA treatment necessary for enhancing the understanding and changing the attitude about OA and its optimal management. This study aims to assess the knowledge of knee braces use in managing knee osteoarthritis among patients aged 36 years and above in Mulago National Referral Hospital. Methodology The study was descriptive, and cross-sectional employing a quantitative data collection approach from 45 respondents. It included all male and female patients diagnosed with knee osteoarthritis in the orthopedic workshop. Results The majority 35(

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19

Mosalem, Douaa M., Shothour M. Alghunaim, Diaa K. Shehab, Ayyoub B. Baqer, Aziz K. Alfeeli, and Mohieldin M. Ahmed. "Soft Tissue Pathology Detected By Ultrasound Seem To Be Risk Factors for Painful Flare in Osteoarthritic Knee." Open Access Macedonian Journal of Medical Sciences 6, no. 9 (2018): 1599–605. http://dx.doi.org/10.3889/oamjms.2018.237.

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BACKGROUND: To our knowledge, the importance of US findings, pain (brief pain inventory (BPI)) and disability in osteoarthritic knee (OA) pain patients remain uncertain. AIM: The objectives are to evaluate the correlation of US findings, pain (brief pain inventory (BPI)) and disability in OA pain patients. MATERIALS AND METHODS: Eighty - three patients with OA knee were divided into two groups. The first group was OA as symptomatic knee group and the second group was an asymptomatic control group. The maximum sagittal height of synovial fluid in 12 scans at 0, 30, 60 and 90 degrees

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20

Gupta, Ashim, and Vijay Kumar Jain. "Autologous peripheral blood-derived orthobiologics: Different types and their effectiveness in managing knee osteoarthritis." World Journal of Orthopedics 15, no. 5 (2024): 400–403. http://dx.doi.org/10.5312/wjo.v15.i5.400.

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Knees are the most commonly impacted weight-bearing joints in osteoarthritis (OA), affecting millions of people worldwide. With increasing life spans and obesity rates, the incidence of knee OA will further increase, leading to a significant increase in the economic burden. Conventional treatment modalities utilized to manage knee OA have limitations. Over the last decade, the role of various autologous peripheral blood-derived orthobiologics (APBOs) for the treatment of knee OA has been extensively investigated. This editorial provided an overview and focused on defining and shedding light on

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21

Mak, Wai Keong, Hamid Rahmatullah Bin Abd Razak, and Hwee-Chye Andrew Tan. "Which Patients Require a Contralateral Total Knee Arthroplasty Within 5 Years of Index Surgery?" Journal of Knee Surgery 33, no. 10 (2019): 1029–33. http://dx.doi.org/10.1055/s-0039-1692653.

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AbstractOsteoarthritis (OA) of the knee often presents bilaterally. However, not all patients with severe bilateral knee OA require bilateral total knee arthroplasty (TKA). This study aims to identify predictive factors for contralateral TKA in patients presenting with severe bilateral knee OA undergoing unilateral TKA. We prospectively collected perioperative data from 209 consecutive patients of a single surgeon who had severe bilateral OA knees at presentation. All patients underwent unilateral TKA on the more symptomatic knee. Patients were then stratified by their need for a contralateral

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22

Zhai, Guangju, Xianbang Sun, Edward W. Randell, et al. "Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study." Journal of Rheumatology 48, no. 1 (2020): 123–28. http://dx.doi.org/10.3899/jrheum.200054.

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Objective.To identify plasma markers associated with an increased risk of radiographic knee osteoarthritis(OA) progression using a metabolomics approach.Methods.Study participants were from the Multicenter Osteoarthritis Study (MOST) and were categorized into 2 groups based on the presence of baseline radiographic OA. Subjects in group 1 had unilateral knee OA and subjects in group 2 had bilateral knee OA. Progression was defined as a half-grade or greater worsening in joint space width at 30-month follow-up. For group 1, a participant progressed when their OA knee showed radiographic progress

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23

Klasan, A., M. Luger, R. Hochgatterer, and SW Young. "Measuring Appropriate Need for Unicompartmental Knee Arthroplasty: Results of the MANUKA study." Orthopaedic Journal of Sports Medicine 9, no. 6_suppl2 (2021): 2325967121S0018. http://dx.doi.org/10.1177/2325967121s00180.

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Purpose: Indications for unicompartmental knee arthroplasty (UKA) are controversial. Studies based solely on radiographic criteria suggest up to 49% of patients with knee osteoarthritis (OA) are suitable for UKA. In contrast, the ‘Appropriate use criteria’ (AUC), developed by the AAOS, apply clinical and radiographic criteria to guide surgical treatment of knee OA. The aim of this study was to analyse patient suitability for TKA, UKA and osteotomy using both radiographic criteria and AUC in a cohort of 300 consecutive knee OA patients. Methods: Included were consecutive patients with clinical

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24

Nakasato, Shinya, Tsukasa Kumai, Tomoki Mitsuoka, Takeshi Teramura, and Masao Akagi. "Combination Therapy of Autologous Protein Solution and Extracorporeal Shock Wave Therapy for Severe Knee Osteoarthritis." Applied Sciences 14, no. 4 (2024): 1498. http://dx.doi.org/10.3390/app14041498.

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Knee osteoarthritis (OA) is a multifaceted metabolic disorder influenced by biomechanical, inflammatory, and immune system factors. Although autologous protein solution (APS) and extracorporeal shock wave therapy (ESWT) have shown promise for treating mild-to-moderate knee OA, their efficacy for severe cases remains limited when administered individually. Thus, we examined the combination effects of APS and ESWT for severe knee OA. Twenty-four cases (33 knees) of Kellgren–Lawrence grade 4 knee OA with bone marrow lesions and synovitis detected via magnetic resonance imaging from December 2019

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Gogoi, Bikash Pratim, Chao Rochek Buragohain, Pranjeet Kalita, and Pranjal Tahbildar. "Prevalence of primary osteoarthritis of knee in tea garden community of Jorhat District, Assam." IP International Journal of Orthopaedic Rheumatology 9, no. 1 (2023): 25–29. http://dx.doi.org/10.18231/j.ijor.2023.004.

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: The most prevalent form of degenerative joint disease, osteoarthritis (OA), is one of the major causes of pain and disability, particularly in middle-aged and older people. OA typically affects the knees, hips, spine, hands, and feet. The knee joint is one of the most commonly affected joint in the lower limb. Though OPD attendance due to OA is quite high, only a few community-based studies are available about its prevalence, especially in the North-Eastern states of India. Assess prevalence of OA of Knee in the Tea Garden community of Jorhat district of Assam. Community-based cross-sectiona

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26

Lyu, Shaw-Ruey. "Knee pain and osteoarthritis (Knee OA) treatment research." Open Access Government 39, no. 1 (2023): 48–49. http://dx.doi.org/10.56367/oag-039-10831.

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Knee pain and osteoarthritis (Knee OA) treatment research Professor Shaw-Ruey Lyu from the School of Medicine, Tzu-Chi University, discusses Knee Pain and Osteoarthritis (Knee OA) Treatment Research, in particular Knee Health Promotion Option (KHPO). Starting from 2002, I conducted a series of studies(1-3,5,6,8,9) to investigate medial abrasion phenomenon (MAP) as a cause of knee OA. I found a high correlation between medial plica-related MAP and knee OA. MAP would elicit lifelong interplay between a pathologic medial plica and the facing medial femoral condyle, and therefore plays a role in t

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Singh, Roop, Puneet Yadav, Shalini Agarwal, Svareen Kaur, and Mantu Jain. "Spine-pelvis-lower extremity alignment in patients with knee osteoarthritis – a gender-based analysis." Chirurgia Narządów Ruchu i Ortopedia Polska 90, no. 2 (2025): 89–105. https://doi.org/10.31139/chnriop.2025.90.2.4.

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Introduction. Osteoarthritis (OA) is a prevalent debilitating ailment among the elderly. OA alters the normal sagittal spine-pelvis-lower extremity alignment and sets the compensatory mechanisms for an upright standing posture in motion. Aim. This study examines whether there is a gender-based difference in lower limb alignment and spino-pelvic angles in OA knees. Materials and methods. This prospective study enrolled 70 adults (19 males and 51 females) over 50 years of age of either sex with knee discomfort and symptomatic OA of at least one knee who consented to the study. The radiological a

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Hasan, Mohd Shifa, Aditya Kumar Mishra, Mohd Bilal Kaleem, and Vikash Thaledi. "Cross-sectional study on the relationship between Body Mass Index and severity of knee osteoarthritis." Romanian Journal of Rheumatology 33, no. 1 (2024): 48–53. http://dx.doi.org/10.37897/rjr.2024.1.11.

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Background. Musculoskeletal diseases like osteoarthritis (OA) are widespread. OA affects the knees, makes the joints wear out and hurt, and makes it hard to move around. Body mass index (BMI) is a way to measure obesity, which is linked to a higher chance of getting OA and making it worse. The main aim of this cross-sectional study was to find out how body mass index (BMI) is related to how lousy knee osteoarthritis is. Methods. One hundred people at the Shri Guru Ram Rai Institute of Medical and Health Sciences in Dehradun met the study’s requirements and were enrolled. The Kellgren-Lawrence

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Overton, Mark, Nicola Swain, Carrie Falling, David Gwynne-Jones, Roger Fillingim, and Ramakrishnan Mani. "Understanding the biopsychosocial knee osteoarthritis pain experience: an ecological momentary assessment." PAIN Reports 9, no. 4 (2024): e1172. http://dx.doi.org/10.1097/pr9.0000000000001172.

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Abstract Introduction: Psychological, social, and lifestyle factors contribute to the knee osteoarthritis (OA) pain experience. These factors could be measured more accurately using smartphone ecological momentary assessment (EMA). Objectives: The objective of this study was to characterise the pain experiences of those with knee OA by a smartphone EMA survey and explain how momentary psychological and social states influence knee OA pain experiences. Methods: A smartphone EMA survey was designed and piloted. Eligible participants completed smartphone EMA assessing the knee OA pain experience

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Mustari, M. Nasser, Muh Nasrum Massi, Muhammad A. Usman, et al. "Dynamic interaction of obesity, age, MCP-1 Level, and ACE-1 gene with the severity of knee osteoarthritis: a cross-sectional study." Annals of Medicine & Surgery 85, no. 8 (2023): 3845–51. http://dx.doi.org/10.1097/ms9.0000000000000973.

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Introduction: The risk factors most strongly associated with knee osteoarthritis (OA) are old age and obesity. However, few studies have evaluated the interaction between aging and obesity in conjunction with inflammatory markers and knee OA severity as part of a complete assessment of knee OA management. Therefore, this study aims to evaluate the interaction between obesity, age, inflammation [including the I/D polymorphism of angiotensin converting enzyme-1 (ACE-1)], and the severity of knee OA. Methods: A total of 80 knee OA patients were included in this cross-sectional study. The severity

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Bentvelzen, Mieke L. M., Paco M. J. Welsing, Philippe Moingeon, et al. "Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort." PLOS One 20, no. 6 (2025): e0325819. https://doi.org/10.1371/journal.pone.0325819.

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Objective Knee osteoarthritis (OA) is a heterogeneous disease with different endotypes and phenotypes, resulting in patients’ varying clinical and structural progression. Several genomic markers have been associated with knee OA presence. This study aimed to find new associations of these genetic markers with knee OA progression and to investigate the risk of knee OA progression using a polygenic risk score (PRS). Methods Data from knee OA patients (n = 297) from the IMI-APPROACH cohort with detailed measurements on disease progression were used. Knee OA progression definitions were based on t

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Pillay, Lervasen, Dina C. Janse van Rensburg, Gopika Ramkilawon, et al. "Determination of the Prevalence of Knee and Hip Clinical Osteoarthritis in the Active Professional Male Footballer and Its Association with Pain, Function, Injury and Surgery." Sports 11, no. 7 (2023): 136. http://dx.doi.org/10.3390/sports11070136.

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Objective: To comment on and explore (1) the prevalence of clinical knee and hip osteoarthritis (OA); (2) the association between pain or function and clinical knee or hip OA; (3) the association between injury or surgery and clinical knee or hip OA. Methods: Participants were recruited from FIFPRO members. A total of 101 footballers consented to answer (1) a developed questionnaire, (2) patient-reported outcome measures, and (3) be evaluated by their team physician for clinical knee or hip OA. Results: Of the 53% evaluated for clinical knee and hip OA, a prevalence of 9.43% and 7.55% of knee

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Nugrahana, Raisa Yunika. "Knee Osteoarthritis Risk Is Increased Five-Fold After Knee Injury In Indonesian National Police Mobile Brigade Corps." Jurnal Ilmiah Kedokteran Wijaya Kusuma 14, no. 1 (2025): 61. https://doi.org/10.30742/jikw.v14i1.4174.

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Abstract Background: Knee osteoarthritis (OA) is a globally alarming condition that is closely related to mechanobiological factors. Based on several previous studies, it is known that knee OA is correlated with knee injury and that play an important role in the expansion of knee OA. Objective: This research aims to find out the relationship between knee injury history with knee OA severity and to estimate the risk of knee OA after knee injury. Methods: This research used observational analytical methods with a retrospective hospital-based cohort study design. Using consecutive sampling techni

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VLAD, STEVEN C., TUHINA NEOGI, PIRAN ALIABADI, JOÃO D. T. FONTES, and DAVID T. FELSON. "No Association Between Markers of Inflammation and Osteoarthritis of the Hands and Knees." Journal of Rheumatology 38, no. 8 (2011): 1665–70. http://dx.doi.org/10.3899/jrheum.100971.

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Objective.Local inflammation plays a prominent role in osteoarthritis (OA). This could be reflected in the presence of elevated soluble inflammatory markers. We conducted analyses to assess the association of inflammatory markers with radiographic OA of the hands and knees in a large community-based cohort.Methods.The Framingham Offspring cohort consists of the adult children of the original cohort and their spouses. In 1998–2001 these subjects provided blood specimens that were tested for 17 markers of systemic inflammation. In 2002–2005 these subjects had radiographs of both knees and hands.

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Carlesso, Lisa C., Jingbo Niu, Neil A. Segal, et al. "The Effect of Widespread Pain on Knee Pain Worsening, Incident Knee Osteoarthritis (OA), and Incident Knee Pain: The Multicenter OA (MOST) Study." Journal of Rheumatology 44, no. 4 (2017): 493–98. http://dx.doi.org/10.3899/jrheum.160853.

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Objective.Whether widespread pain (WSP) affects the risk of developing knee pain or knee osteoarthritis (OA) is unknown and could enhance understanding of pain mechanisms in OA.Methods.Subjects from the Multicenter OA (MOST) study, a US National Institutes of Health–funded prospective cohort of older adults with or at risk of knee OA, were characterized regarding WSP, defined as pain above and below the waist on both sides of the body and axially using a standard homunculus, excluding knee pain at 60 months (baseline). Followup occurred 2 years later. We assessed the relation of WSP to odds of

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Phalswal, Uma, Vandna Pandey, Ashok Kumar, and Abhay Elhence. "Correlation of Ahlback grading and knee society score in patients with moderate to severe osteoarthritis of the knee." International Journal of Research in Orthopaedics 7, no. 3 (2021): 606. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20211617.

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<p class="abstract"><strong>Background:</strong> Knee osteoarthritis (OA) is a most common rheumatological disorder that causes functional limitation and disability. The most common problem in knee OA are joint pain and stiffness. It will lead to decreased quality of life and it have a serious economic burden on any country due to effect of disability and treatment.</p><p class="abstract"><strong>Methods:</strong> A correlational study was conducted to find out correlation between Ahlback grading and knee society score (KSS) on a sample of 100 moderate

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Terpstra, S., L. A. Van de Stadt, F. Berenbaum, et al. "POS0965 SEVERITY AND PROGRESSION OF RADIOGRAPHIC HAND OA IS NOT ASSOCIATED WITH PROGRESSION OF RADIOGRAPHIC KNEE OA: THE IMI-APPROACH COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 796.1–796. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3094.

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BackgroundOsteoarthritis (OA) frequently affects multiple joints including the knees and hands. Currently, it is unknown which patients with knee OA have the highest risk to progress, and how these patients can be identified.ObjectivesTo investigate the association of radiographic hand OA and its progression with radiographic knee OA progression over two years of follow-up.MethodsWe used baseline and two-year follow-up data from the Applied Public-Private Research enabling OA Clinical Headway (IMI-APPROACH) cohort. This cohort consists of participants fulfilling the American College of Rheumat

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Yan, Laijun, Haiya Ge, Zhengming Wang, et al. "Roles of low muscle strength and sarcopenic obesity on incident symptomatic knee osteoarthritis: A longitudinal cohort study." PLOS ONE 19, no. 10 (2024): e0311423. http://dx.doi.org/10.1371/journal.pone.0311423.

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Objectives Sarcopenia is prevalent in middle to old age. We aimed to investigate the association between muscle strength and the incident knee osteoarthritis (OA). Methods 12,043 participants were collected from the China Health and Retirement Longitudinal Study. The effects of sarcopenic obesity (defined by obesity in combination with possible sarcopenia) on knee OA onset were calculated using Poisson regression models. Mediation analysis was fit to estimate mediating proportion of muscle strength on the association between obesity and incident knee OA. Results The study all enrolled 12,043 p

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Soong, Junwei, Youheng Ou Yang, Zhixing Marcus Ling, Shi-Lu Chia, Ngai Nung Lo, and Seng Jin Yeo. "Cruciate retaining and posterior stabilized total knee arthroplasty in severe varus osteoarthritis knee: A match-pair comparative study in an Asian population." Journal of Orthopaedic Surgery 29, no. 3 (2021): 230949902110552. http://dx.doi.org/10.1177/23094990211055224.

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Background Posterior stabilized (PS) total knee arthroplasty (TKA) is advocated in severe varus osteoarthritic (OA) knees as the posterior cruciate ligament posed challenges in gap balancing. However, there is scarcity in the literature to illustrate the superiority of PS TKA over cruciate retaining (CR) TKA. Our study aims to compare the outcomes between CR and PS TKAs in patients with severe varus OA knees. Methods: A retrospective review was conducted on patients who underwent primary TKA for OA knee from 2003 to 2013. Patients with OA knees of varus tibiofemoral angle ≥15 were matched into

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Moore, Joss, Victor A. van de Graaf, Jil A. Wood, et al. "Windswept deformity of the knee: prevalence and predictive factors in osteoarthritic and healthy populations." Bone & Joint Open 5, no. 10 (2024): 879–85. http://dx.doi.org/10.1302/2633-1462.510.bjo-2024-0128.

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AimsThis study examined windswept deformity (WSD) of the knee, comparing prevalence and contributing factors in healthy and osteoarthritic (OA) cohorts.MethodsA case-control radiological study was undertaken comparing 500 healthy knees (250 adults) with a consecutive sample of 710 OA knees (355 adults) undergoing bilateral total knee arthroplasty. The mechanical hip-knee-ankle angle (mHKA), medial proximal tibial angle (MPTA), and lateral distal femoral angle (LDFA) were determined for each knee, and the arithmetic hip-knee-ankle angle (aHKA), joint line obliquity, and Coronal Plane Alignment

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van der Esch, M., M. Steultjens, J. Harlaar, N. Wolterbeek, D. Knol, and J. Dekker. "Varus–valgus motion and functional ability in patients with knee osteoarthritis." Annals of the Rheumatic Diseases 67, no. 4 (2007): 471–77. http://dx.doi.org/10.1136/ard.2007.071258.

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Objective:To assess the relationship between knee varus–valgus motion and functional ability, and the impact of knee varus–valgus motion on the relationship between muscle strength and functional ability in patients with osteoarthritis (OA) of the knee.Methods:Sixty-three patients with knee OA were tested. Varus–valgus motion was assessed by optoelectronic recording and three-dimensional motion analysis. Functional ability was assessed by observation, using a 100 m walking test, a Get Up and Go test, and WOMAC questionnaire. Muscle strength was measured by a computer-driven isokinetic dynamome

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Driban, Jeffrey B., Jennifer M. Hootman, Michael R. Sitler, Kyle P. Harris, and Nicole M. Cattano. "Is Participation in Certain Sports Associated With Knee Osteoarthritis? A Systematic Review." Journal of Athletic Training 52, no. 6 (2017): 497–506. http://dx.doi.org/10.4085/1062-6050-50.2.08.

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Objective: Information regarding the relative risks of developing knee osteoarthritis (OA) as a result of sport participation is critical for shaping public health messages and for informing knee-OA prevention strategies. The purpose of this systematic review was to investigate the association between participation in specific sports and knee OA. Data Sources: We completed a systematic literature search in September 2012 using 6 bibliographic databases (PubMed; Ovid MEDLINE; Journals@Ovid; American College of Physicians Journal Club; Cochrane Central Register of Controlled Trials, Cochrane Dat

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Liebl, Hans, Gabby Joseph, Michael C. Nevitt, et al. "Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative." Annals of the Rheumatic Diseases 74, no. 7 (2014): 1353–59. http://dx.doi.org/10.1136/annrheumdis-2013-204157.

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ObjectiveTo evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict the onset of radiographic knee osteoarthritis (OA).Materials and methodsWe performed a nested case–control study of incident radiographic knee OA in the Osteoarthritis Initiative cohort. Cases were 50 knees with baseline Kellgren–Lawrence (KL) grade of 0 that developed KL grade of 2 or more over a 4-year period. Controls were 80 knees with KL grade of 0 after 4 years of follow-up. Baseline T2 relaxation time measurements and laminar analysis of T2 in deep and superficial layers were performed in all knee c

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Teoh, Yun Xin, Khin Wee Lai, Juliana Usman, et al. "Discovering Knee Osteoarthritis Imaging Features for Diagnosis and Prognosis: Review of Manual Imaging Grading and Machine Learning Approaches." Journal of Healthcare Engineering 2022 (February 18, 2022): 1–19. http://dx.doi.org/10.1155/2022/4138666.

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Knee osteoarthritis (OA) is a deliberating joint disorder characterized by cartilage loss that can be captured by imaging modalities and translated into imaging features. Observing imaging features is a well-known objective assessment for knee OA disorder. However, the variety of imaging features is rarely discussed. This study reviews knee OA imaging features with respect to different imaging modalities for traditional OA diagnosis and updates recent image-based machine learning approaches for knee OA diagnosis and prognosis. Although most studies recognized X-ray as standard imaging option f

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Campbell, Thomas Mark, Guy Trudel, Kayleigh Kristin Wong, and Odette Laneuville. "Genome wide Gene Expression Analysis of the Posterior Capsule in Patients with Osteoarthritis and Knee Flexion Contracture." Journal of Rheumatology 41, no. 11 (2014): 2232–39. http://dx.doi.org/10.3899/jrheum.140079.

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Objective.Knee flexion contractures (KFC) are limitations in the ability to fully extend the knee joint. In people with knee osteoarthritis (OA), KFC are common, impair function, and worsen outcomes after arthroplasty. In KFC, the posterior knee capsule is believed to play a key role, but the pathophysiology remains poorly understood. We sought to identify gene expression differences in the posterior knee capsule of patients with OA with and without KFC.Methods.Capsule tissue was obtained from the knees of 12 subjects diagnosed with advanced-stage OA at the time of knee arthroplasty surgery. T

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Wilder, Frances Vaughn, Paul E. Leaverton, Matthew W. Rogers, and Nancy B. Lemrow. "VITAMIN SUPPLEMENTS AND RADIOGRAPHIC KNEE OSTEOARTHRITIS: THE CLEARWATER OSTEOARTHRITIS STUDY." Journal of Musculoskeletal Research 12, no. 02 (2009): 85–93. http://dx.doi.org/10.1142/s0218957709002274.

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Objective: To evaluate the association between vitamin supplements and the incidence and progression of radiographic knee osteoarthritis (OA). Study Design: Prospective cohort. Methods: Men and women aged 40 years and older (N = 2239) participating in the community-based Clearwater Osteoarthritis Study (1988–current) with biennial, sequential radiographs. The Lawrence & Kellgren ordinal scale was used to determine evidence of the study outcome, radiographic knee OA, and progression of radiographic knee OA. The study exposure was baseline history of self-reported vitamin supplement usage. R

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Testa, Gianluca, Serena Maria Chiara Giardina, Annalisa Culmone, et al. "Intra-Articular Injections in Knee Osteoarthritis: A Review of Literature." Journal of Functional Morphology and Kinesiology 6, no. 1 (2021): 15. http://dx.doi.org/10.3390/jfmk6010015.

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Knee osteoarthritis (OA) is a chronic, degenerative, and progressive disease of articular cartilage, producing discomfort and physical disability in older adults. Thirteen percent of elderly people complain of knee OA. Management options for knee OA could be divided into the following categories: conservative, pharmacological, procedural, and surgical. Joint replacement is the gold standard, reserved for severe grades of knee OA, due to its complications rate and increased risk of joint revision. A nonsurgical approach is the first choice in the adult population with cartilage damage and knee

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Shirinsky, I., and V. Shirinsky. "POS1131 ASSOCIATION BETWEEN ANTIBIOTIC USE AND RADIOGRAPHIC PROGRESSION OF OA: DATA FROM THE OSTEOARTHRITIS INITIATIVE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 894.2–894. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4438.

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BackgroundGut dysbiosis has been proposed as one risk factor for osteoarthritis (OA) (1).To date, there have been no studies assessing association between the use of antibiotics and structural progression of knee OA.ObjectivesTo evaluate association between the use of antibiotics and radiographic progression of knee OA.MethodsFor the current study we used 9-year longitudinal data obtained from the Osteoarthritis Initiative (OAI) progression (n= 1390) and incidence (n = 3284) subcohorts, which are publically available at https://oai.nih.gov. For the assessment of antibiotic influence on knee OA

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Ro, Du Hyun, Joonhee Lee, Jangyun Lee, Jae-Young Park, Hyuk-Soo Han, and Myung Chul Lee. "Effects of Knee Osteoarthritis on Hip and Ankle Gait Mechanics." Advances in Orthopedics 2019 (March 24, 2019): 1–6. http://dx.doi.org/10.1155/2019/9757369.

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Introduction. Knee osteoarthritis (OA) can affect the hip and ankle joints, as these three joints operate as a kinetic/kinematic chain while walking. Purpose. This study was performed to compare (1) hip and ankle joint gait mechanics between knee OA and control groups and (2) to investigate the effects of knee gait mechanics on the ipsilateral hip and ankle joint. Methods. The study group included 89 patients with end-stage knee OA and 42 age- and sex-matched controls without knee pain or OA. Kinetic and kinematic parameters were evaluated using a commercial optoelectric gait analysis system.

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Terpstra, S., J. Van der Velde, R. De Mutsert, et al. "POS1431 THE ASSOCIATION OF CLINICAL AND STRUCTURAL KNEE OSTEOARTHRITIS WITH PHYSICAL ACTIVITY IN THE MIDDLE-AGED POPULATION: THE NEO STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 999.2–1000. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2363.

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Background:Lack of physical activity in individuals with knee OA has shown to be associated with increased cardiovascular risk and mortality. Consequently, physical activity is a potential target for interventions in knee OA. However, most of the available studies concerning physical activity in individuals with knee OA were performed in relatively old populations with an inactive lifestyle. It is unclear how previous results can be generalized to other populations with different lifestyle and physical activity habits.Objectives:To investigate if knee OA is associated with lower physical activ

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