Готові списки джерел за темами / OA Rat Model

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Добірка наукової літератури з теми "OA Rat Model"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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Статті в журналах з теми "OA Rat Model"

McHugh, Jessica. "GDF5 modifies disease in OA rat model." Nature Reviews Rheumatology 13, no. 1 (2016): 3. http://dx.doi.org/10.1038/nrrheum.2016.199.

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Liu, Zili, Honglin Wang, Shaoqian Wang, Jie Gao, and Lei Niu. "PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis." Bone & Joint Research 10, no. 7 (2021): 401–10. http://dx.doi.org/10.1302/2046-3758.107.bjr-2020-0200.r2.

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Aims Poly (ADP-ribose) polymerase (PARP) inhibitor has been reported to attenuate inflammatory response in rat models of inflammation. This study was designed to investigate the effect of PARP signalling in osteoarthritis (OA) cartilage inflammatory response in an OA rat model. Methods The OA model was established by anterior cruciate ligament transection with medial meniscectomy in Wistar rats. The poly (ADP-ribose) polymerase 1 (PARP-1) shRNA (short hairpin (sh)-PARP-1) and negative control shRNA (sh-NC) were delivered using a lentiviral vector and were intra-articularly injected into rats a

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Lee, Lee, Moon та ін. "Membrane-Free Stem Cell Components Inhibit Interleukin-1α-Stimulated Inflammation and Cartilage Degradation in vitro and in vivo: A Rat Model of Osteoarthritis". International Journal of Molecular Sciences 20, № 19 (2019): 4869. http://dx.doi.org/10.3390/ijms20194869.

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Membrane-free stem cell components (MFSCC) from basal adipose tissue-derived stem cells (ADSCs) are unknown for the treatment strategies in osteoarthritis (OA). OA has been considered to be associated with inflammatory damage and cartilage degradation. In this study, we intended to investigate the molecular mechanism of the anti-inflammation and cartilage protection effect of MFSCC in vitro (rat primary chondrocytes) and in vivo (rat OA model). The MFSCC treatment significantly inhibited interleukin-1α (IL-1α) stimulated inflammation and cartilage degradation. The MFSCC considerably reduced th

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Sofia, Vivi, Moch Saiful Bachri, and Endrinaldi Endrinaldi. "The Effect of Mesenchymal Stem Cell Wharton’s Jelly on Nuclear Factor Kappa Beta and Interleukin-10 Levels in Osteoarthritis Rat Model." Open Access Macedonian Journal of Medical Sciences 8, B (2020): 350–57. http://dx.doi.org/10.3889/oamjms.2020.4465.

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BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease in one or more joints characterized by changes in pathological structures such as cartilage, hypertrophy, and remodeling of the subchondral bone and secondary inflammation of the synovium membrane, causing changes in joint components such as cells, matrices, and molecular production. At the molecular level, an imbalance between catabolic and anabolic activities in joint cartilage results in OA. Nuclear factor kappa beta (NFκβ) is a cytokine that plays an important role in the signaling pathway of the pathogenesis of OA in causing

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Hamza, Reham, Fawziah Al-Salmi, and Nahla El-Shenawy. "Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model." Molecules 25, no. 23 (2020): 5738. http://dx.doi.org/10.3390/molecules25235738.

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The present work aimed to assess the chondroprotective influence of chitosan and lecithin in a monoiodoacetate (MIA)-induced experimental osteoarthritis (OA) model. Forty male rats weighing 180–200 g were randomly distributed among the following five experimental groups (eight per group): control, MIA-induced OA, MIA-induced OA + chitosan, MIA-induced OA + lecithin, and MIA-induced OA + chitosan + lecithin. The levels of TNF-α, IL6, RF, ROS, and CRP, as well as mitochondrial markers such as mitochondrial swelling, cytochrome C oxidase (complex IV), MMP, and serum oxidative/antioxidant status (

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Zhang, Jun, Jing Yin, Daohong Zhao, et al. "Therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis." Journal of International Medical Research 48, no. 3 (2019): 030006051987346. http://dx.doi.org/10.1177/0300060519873461.

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Objective To study the therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis (OA). Methods The OA rat model was established by intra-articular injection of papain. Changes in knee diameter, toe volume and histopathology were measured. Levels of interleukin (IL)-β and tumor necrosis factor (TNF)-α were assessed by ELISA. Relative expression of Toll-like receptor (TLR)-4 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was evaluated by western blotting. Results Compared with rats treated with papain alone, changes in knee diameter, toe

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Korostyński, Michał, Natalia Małek, Marcin Piechota, and Katarzyna Starowicz. "Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis." International Journal of Genomics 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/1746426.

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Biomarkers of osteoarthritis (OA) that can accurately diagnose the disease at the earliest stage would significantly support efforts to develop treatments for prevention and early intervention. We have sought to determine the time course of alterations in peripheral blood gene expression profile associated with the development of OA. Blood samples were collected from a tail vein of individual rats with monosodium iodoacetate- (MIA-) induced OA (2, 14, 21, and 28 days after the treatment). We used whole-genome microarrays to reveal OA-related transcriptional alterations of 72 transcripts. Three

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Qian, Zhigang, Xuanliang Ru, Chun Liu, Xiaoqin Huang, and Qicai Sun. "Fraxin Prevents Knee Osteoarthritis through Inhibiting Chondrocyte Apoptosis in an Experimental Rat Osteoarthritis Model." Protein & Peptide Letters 28, no. 11 (2021): 1298–302. http://dx.doi.org/10.2174/0929866528666211022152556.

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Background: Current treatments of osteoarthritis are unsatisfied, a new approach towards the treatment of osteoarthritis is urged considering the state at present. Objectives: The objective of this study is to investigate the effect of fraxin on knee OA in a rat model and probe into the possible molecular mechanism. Methods: Primary Murine Chondrocytes were isolated and cell apoptosis analyses were performed. Rat OA models were established using meniscectomy method and allocated into three groups. Knee joint specimens were collected for qRT-PCR, western blotting and histological analysis. Stat

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Liu, Yubao, Rui Zou, Zhen Wang, Chuanyang Wen, Fan Zhang, and Fuqing Lin. "Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis." Biochemical Journal 475, no. 22 (2018): 3629–38. http://dx.doi.org/10.1042/bcj20180675.

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The present study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for osteoarthritis (OA). hMSCs and MSC-derived exosomes (MSC-exo) were prepared for morphological observation and identification by transmission electron microscopy and flow cytometry. IL-1β-induced OA chondrocytes and collagenase-induced rat model of OA were established for the further experiments. Lentivirus-mediated siRNA targeting KLF3-AS1 was transfected into MSCs for silencing KLF3-AS1. The real-time quantitative PCR and western bl

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Wei, Yingliang, Yanfang Wang, Yutong Wang, and Lunhao Bai. "Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model." Cellular Physiology and Biochemistry 42, no. 1 (2017): 319–32. http://dx.doi.org/10.1159/000477387.

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Background: Autophagy, a self-protective mechanism of chondrocytes, has become a promising target to impede the progress of osteoarthritis (OA). Autophagy is regulated by cytosolic Ca2+ activity and may thus be modified by the Ca2+ permeable transient receptor potential channel vanilloid 5 (TRPV5). Therefore, we investigated the potential role of TRPV5 in mediating Ca2+ influx and in inhibiting chondrocyte autophagy in a rat OA model. Methods: The rat OA model was assessed by macroscopic and histological analyses. light chain 3B (LC3B) immunolocalization was detected by immunohistochemistry. T

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Більше джерел

Дисертації з теми "OA Rat Model"

Tumkur, Jaiprakash Anjali. "Phenotypical changes of osteocytes in osteoarthritis." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/79552/1/Anjali_Tumkur%20Jaiprakash_Thesis.pdf.

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This thesis focuses on the role of a bone cell, osteocytes in the progression of osteoarthritis. The biological relevance of this study has opened doors to new possibilities of understanding the pathogenesis of osteoarthritis.

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Частини книг з теми "OA Rat Model"

Gethsia, P., J. Anitha, D. Sujitha Juliet, S. Immanuel Alex Pandian, and R. V. Belfin. "Deep Learning Models for Knee Osteoarthritis Diagnosis." In Synergizing Data Envelopment Analysis and Machine Learning for Performance Optimization in Healthcare. IGI Global, 2025. https://doi.org/10.4018/979-8-3373-0081-8.ch011.

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Knee Osteoarthritis (OA) is one of the most common forms of arthritis and is primarily a degenerative joint disease. It causes pain, stiffness, and loss of movement in the knee joint by affecting the surrounding tissues, bones, and cartilage. Manual diagnosis of this condition involves looking at knee region X-ray images and using the Kellgren-Lawrence (KL) system to categorize severity levels. Conventional techniques for identifying and classifying osteoarthritis, such as manual radiography evaluation, are frequently laborious and subjective. This chapter introduces an automated system for cl

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Emmett, Stevan R., Nicola Hill, and Federico Dajas-Bailador. "Musculoskeletal medicine." In Clinical Pharmacology for Prescribing. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780199694938.003.0015.

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Osteoarthritis (OA) is best described as a chronic pain syndrome affecting one, or more frequently, multiple joints. It most commonly affects the knees, hips, hands, neck and lower back, although any joint can be affected. Defining OA by pathological changes is no longer considered best practice, as the correlation between pathology and symptoms is frequently discordant, i.e. patients with severe structural changes may present with minimum symptoms and vice versa. For this reason, patients should be assessed using a biopsychosocial model, which takes into consideration impact on social and

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Тези доповідей конференцій з теми "OA Rat Model"

Durnie, W. H., and M. A. Gough. "Characterization, Isolation and Performance Characteristics of Imidazolines. Part II. Development of Structure - Activity Relationships." In CORROSION 2003. NACE International, 2003. https://doi.org/10.5006/c2003-03336.

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Abstract Imidazolines have been used in the area of corrosion inhibition since at least the mid 1940’s when it was shown that long chain organic compounds with polar functional groups had corrosion inhibition properties when applied to oil-field environments. Part I. of this paper reported the synthesis, separation/isolation and performance characteristics of various imidazoline species synthesised from oleic acid (OA) and diethylenetriamine (DETA). These techniques have been employed in order to yield relatively ‘pure’ imidazolines for more detailed study. This paper presents the preliminary

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Nicoll, Steven B., Christopher K. Hee, Martin B. Davis, and Beth A. Winkelstein. "A Rat Model of Osteoarthritic Temporomandibular Joint Pain: Mechanically-Induced Behavioral Hypersensitivity and Histologic Modifications." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176520.

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Orofacial pain associated with osteoarthritis (OA) in the temporomandibular joint (TMJ) is a significant clinical problem [1]. The pathophysiologic and cellular mediators that underlie the development of such chronic orofacial pain are not well understood, nor has a relationship to mechanical loading been defined. Several experimental models have been developed to examine causative factors in TMJ OA progression and joint pathology. Such models often involve intra-articular injections or surgical manipulation of tissue structures in order to alter joint kinematics and stability [2–6]. For examp

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Walter, Jonathan P., Hugh Pun, Terese L. Chmielewski, Newton Chan, and Benjamin J. Fregly. "Real-Time Model-Based Gait Retraining for Knee Osteoarthritis Rehabilitation." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206567.

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According to the Arthritis Foundation, 66 million Americans (or nearly 1 in 3 adults) currently suffer from arthritis, with osteoarthritis (OA) being the most common form, and the knee being the joint most commonly affected. Despite the need for early treatment, few clinical interventions slow the progression of knee OA. Since articular cartilage is responsive to the amount of joint loading, reducing compressive loads in the diseased compartment may slow the rate of cartilage breakdown. Because medial compartment load cannot be measured non-invasively in vivo, an external measure to quantify t

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Jiangbo, Li, Niu Shihang, Ouyang Wenhao, Li Jian, and Zhang Mingyue. "The Trends of Open Access Academic Books and Discipline Dynamics: A Cross-database Comparison Based on OpenAlex and Web of Science." In 20th International Conference on Scientometrics & Informetrics. Institute for Informatics and Automation Problems of NAS RA, 2025. https://doi.org/10.51408/issi2025_038.

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This study conducts a quantitative analysis of the inclusion of open access (OA) academic books in the OpenAlex and Web of Science (WoS) databases from 2004 to 2023. It explores the differences and trends between the two databases in terms of the number of OA books, annual variations, and disciplinary distribution. The study finds that OpenAlex shows a significant advantage over WoS in the scale of OA book inclusion and growth rate, with a particularly strong growth potential in recent years. Through an analysis of various academic disciplines, this study reveals the differences in disciplinar

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Vasil’ev, M. V., V. A. Berenberg, A. A. Leshchev, and V. Yu Venediktov. "Polychrome Correction for Telescope Lens Distortions using Optically Addressed Liquid Crystal Spatial Light Modulator." In The European Conference on Lasers and Electro-Optics. Optica Publishing Group, 1998. http://dx.doi.org/10.1364/cleo_europe.1998.cthh64.

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Holographic correction for telescope lens distortions was first proposed and realised yet in 70-es1; in this and more recent experiments2 the holograms were recorded in the static media, providing thus correction only for static distortions. The prospective scheme, which can be used for real-time dynamic correction in wide spectral range, uses thin (plain) dynamic hologram record in the optically addressed liquid crystal spatial light modulators (OA LC SLM). In the experiment we have evaluated wide spectral band imaging by model telescope with the distorted primary lens of the standard test ob

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