Добірка наукової літератури з теми "Oxygen indicators"

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Статті в журналах з теми "Oxygen indicators":

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Lee, Eric D., Thomas C. Werner, and W. Rudolf Seitz. "Luminescence ratio indicators for oxygen." Analytical Chemistry 59, no. 2 (January 15, 1987): 279–83. http://dx.doi.org/10.1021/ac00129a013.

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2

Quaranta, Michela, Sergey M. Borisov, and Ingo Klimant. "Indicators for optical oxygen sensors." Bioanalytical Reviews 4, no. 2-4 (November 24, 2012): 115–57. http://dx.doi.org/10.1007/s12566-012-0032-y.

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Jiarun, Yin. "Stable carbon and oxygen isotopes in Jurassic shells as palaeosalinity indicators." Neues Jahrbuch für Geologie und Paläontologie - Monatshefte 1991, no. 3 (March 4, 1991): 163–76. http://dx.doi.org/10.1127/njgpm/1991/1991/163.

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4

Wen, Junwei, Shuting Huang, Yu Sun, Zhengjie Chen, Yixiang Wang, Houbin Li, and Xinghai Liu. "Titanium Dioxide Nanotube-Based Oxygen Indicator for Modified Atmosphere Packaging: Efficiency and Accuracy." Materials 11, no. 12 (November 29, 2018): 2410. http://dx.doi.org/10.3390/ma11122410.

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Colorimetric oxygen indicators can be applied for non-destructive testing in packaging; especially in modified atmosphere packaging (MAP). In this paper; titanium dioxide (TiO2) nanotube; which is used as a semiconductor photocatalyst in oxygen indicators; was synthesized via a microwave-assisted hydrothermal method. X-Ray Diffraction (XRD) was used to analyze its crystal form and Scanning Electron Microscope (SEM).to characterize its morphology. Its properties were studied using Brunauer-Emmett-Teller (BET), Diffuse Reflection Spectrum (DRS), and Bluebottle experiments. The results showed that the synthesized TiO2 nanotube was a mixture of rutile and anatase; with a specific surface area of 190.35 m2/g; and a wide band gap of 3.34 eV. Given the satisfactory performance; the TiO2-based oxygen indicator was prepared and combined with glycerol; methylene blue; and hydroxyethyl cellulose (HEC). The oxygen indicator demonstrated excellent photocatalytic performance and effectively avoided excitation by visible light. We studied the rheological properties; thixotropic properties; and wettability of the indicator. The results demonstrated the printability of the indicator solution; which was then printed in the polyethylene terephthalate (PET) film by screen printing and applied to MAP. The application results showed that the prepared oxygen indicator was able to provide visual support to judge whether the packaging was intact and the food was safe.
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Mills, Andrew. "Oxygen indicators and intelligent inks for packaging food." Chemical Society Reviews 34, no. 12 (2005): 1003. http://dx.doi.org/10.1039/b503997p.

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6

Boas, David A., and Maria Angela Franceschini. "Haemoglobin oxygen saturation as a biomarker: the problem and a solution." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 369, no. 1955 (November 28, 2011): 4407–24. http://dx.doi.org/10.1098/rsta.2011.0250.

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Near-infrared spectroscopy measures of haemoglobin oxygen saturation are often used as an indicator of sufficient oxygen delivery to assess injury susceptibility and tissue damage. They have also often been used as a surrogate measure of oxygen metabolism. Unfortunately, these measures have generally failed to provide robust indicators of injury and metabolism. In this paper, we first review when haemoglobin oxygen saturation does work as a robust indicator, and then detail when and why it fails for assessing brain injury and breast cancer. Finally, we discuss the solution to obtain more robust measures of tissue injury and cancer by combining oxygen saturation measurements with measures of blood flow and volume to more accurately estimate oxygen metabolism.
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Spasojevic, Slobodan, and Aleksandra Bregun-Doronjski. "Pain indicators in newborns." Medical review 61, no. 1-2 (2008): 37–42. http://dx.doi.org/10.2298/mpns0802037s.

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Definition of pain. The International Association for the Study of Pain has defined pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage." The interpretation of pain is subjective. Each person forms an internal construct of pain through encountered injury. Pain and newborn. The issue of pain perception in newborns, its management and prevention has been neglected for decades. The inability of "self-report" of painful experience has contributed significantly to misunderstanding of the importance of this problem and in?adequate treatment. The main characteristic of this 'critical window of brain development' period is rapid enlargement of brain volume and its great plasticity. Harmful short-term and long-term consequences can arise as a consequence of disturbance of the sophisticated balance between newborn and its surrounding. Neonatal pain indicators. As a response to a present painful stimulus, the newborn adapts to this acute stress with changes in endocrine, vegetative, immune and behavioral area. An ideal pain indicator in neonatal period does not exist. There are several different groups o them, namely contextual and developmental indicators (gestational age, contributed illness, medication, for example), physiological (heart rate, vagal tone, breathing rate, blood pressure, oxygen saturation, transcutaneous partial pressures of oxygen and carbon-dioxide, intracranial pressure, palm sweating) and behavioral ones (face expression, movements of limbs, cry), several neonatal pain scales were constructed on the basis of these indicators. .
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Fornal, Maria, Natalia Piergies, Ewa Pięta, Tomasz P. Wrobel, Wojciech M. Kwiatek, Czesława Paluszkiewicz, Jarosław Królczyk, and Tomasz Grodzicki. "Triglycerides as indicators of erythrocyte hemoglobin oxygen-binding properties1." Clinical Hemorheology and Microcirculation 69, no. 1-2 (May 4, 2018): 289–94. http://dx.doi.org/10.3233/ch-189127.

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Shillingford, Cicely, Calvin W. Russell, Ian B. Burgess, and Joanna Aizenberg. "Bioinspired Artificial Melanosomes As Colorimetric Indicators of Oxygen Exposure." ACS Applied Materials & Interfaces 8, no. 7 (February 15, 2016): 4314–17. http://dx.doi.org/10.1021/acsami.5b11933.

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Roberts, Luke, Robert Lines, Sub Reddy, and John Hay. "Investigation of polyviologens as oxygen indicators in food packaging." Sensors and Actuators B: Chemical 152, no. 1 (February 2011): 63–67. http://dx.doi.org/10.1016/j.snb.2010.09.047.

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Дисертації з теми "Oxygen indicators":

1

Motz, John Edward. "Oxygen and hydrogen isotopes in fossil insect chitin as paleoenvironmental indicators." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ51214.pdf.

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Dooley, Colette. "Green fluorescent protein based indicators of dynamic redox changes and reactive oxygen species." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3211820.

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Thesis (Ph. D.)--University of California, San Diego, 2006.
Title from first page of PDF file (viewed June 16, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Schaller, Tobias Lukas. "Redox-sensitive metals in recent lake sediments proxy-indicators of deep-water oxygen and climate conditions /." [S.l.] : [s.n.], 1996. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=11901.

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Dennison-Budak, Cordelia W. "Ostracodes as indicators of the Paleoenvironment in the Pliocene Glenns Ferry Formation, Glenns Ferry Lake, Idaho." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271442702.

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Tatzel, Michael [Verfasser]. "Silicon and oxygen stable isotopes in chert as indicators of diagenesis and ocean paleo-environmental conditions / Michael Tatzel." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1104733781/34.

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Devor, Devin Patrick. "Effects of Hyperoxia on Thermal Tolerance and Indicators of Hypoxic Stress in Antarctic Fishes That Differ in Expression of Oxygen-Binding Proteins." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1362666619.

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Devata, Naveen Kumar. "Indicators for Minimizing Energy Consumption and GHG Emissions at Wastewater Treatment Facilities." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1208.

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Wastewater treatment facilities around the world use significant amount of energy which contributes to large quantities of greenhouse gas (GHG) emissions. According to the U.S.EPA, nearly 3% of the USA's energy is used to treat wastewater. This consumption is increasing at faster rates with increase in population and regulations. Wastewater facilities use large number of pumps in their transfer stations, treatment plants, and effluent pump stations. All these pumps consume considerable amounts of energy. This study presents a preliminary energy inspection of two facilities from Louisiana. This audit provides an inventory of the energy consumed for various activities like pumping, treatment, and discharge. This analysis helps the operators to identify the potential power consuming areas and optimize by adopting several energy conservation measures (ECMs). This study also involves the quantification of GHG emissions based on the energy consumption. The benefits of the study include minimizing energy and GHG emission.
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Dobiáš, Vojtěch. "Senzor kvality prostředí potravinového obalu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449725.

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The aim of this study was to prepare thin polymer layers able to give a color change response to oxygen. Thin layers were prepared with different polymers and dyes. The rate of photocatalytic reduction of a dye and the rate of the color change response to oxygen were studied. To verify oxygen sensitivity of a prepared layer, oxygen absorbers were used to create anaerobic conditions. The effect of visible light irradiation on a prepared layer was examined as well. Influence of glycerol content on the kinetics of the photocatalytic reduction and the color change response was studied. Considering both reactions, the glycerol content of 1 % was found to be the most suitable. Methylene blue in prepared layer was reduced 48 s after previous UVA irradiation with intensity of 0,1 mWcm-2. The color change response to oxygen is readily distinguished by the naked eye within 20 minutes.
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Scott, Christopher Ben 1961. "The maximally accumulated oxygen deficit as an indicator of anaerobic capacity." Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/278205.

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The purpose of this study was to determine whether maximally accumulated oxygen deficit (OD) was a valid index of anaerobic capacity by distinguishing among groups of aerobically and anaerobically trained athletes. In addition, OD was correlated with commonly used anaerobic capacity/power measures. Subjects were four distance and five middle distance runners, three sprinters, and four controls. Subjects performed one 2-3 minute supra-maximal treadmill run in which blood lactates were recorded, a Wingate Bicycle Ergometer Test, and runs of 300, 400, and 600 meters. Data were analyzed by ANOVA and a Duncan's Multiple Range test. Significant differences in OD were found between: sprinters and middle distance runners vs. distance runners and controls suggesting a greater anaerobic capacity in the former two groups. Significant correlations also were found between OD and the other anaerobic tests. This study demonstrates that OD can distinguish among groups of track athletes whose events require varying levels of anaerobic metabolism. Correlations between OD and selected field tests suggest that the latter are measuring some common aspects of anaerobic ability.
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Pollack, Gerald D. "Timing and Characterization of the Change in the Redox State of Uranium in Precambrian Surface Environments: A Proxy for the Oxidation State of the Atmosphere." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-12052008-125923/.

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Thesis (Ph. D.)--Georgia State University, 2008.
Title from file title page. Eirik J. Krogstad, committee chair; Andrey Bekker, committee co-chair; W. Crawford Elliott, Timothy E. LaTour, committee members. Description based on contents viewed Aug. 27, 2009. Includes bibliographical references (p. 207-219).

Книги з теми "Oxygen indicators":

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Achkasov, Evgeniy, Yuriy Vinnik, and Svetlana Dunaevskaya. Immunopathogenesis of acute pancreatitis. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1089245.

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The monograph devoted to the study of the role of the immune system in the development and progression of acute pancreatitis consistently covers the issues of etiology, classification, diagnosis and modern treatment principles. Special attention is paid to the issues of non-specific immune protection, indicators of immune status, types of generation of reactive oxygen species in macrophage-granulocyte cells depending on the severity of acute pancreatitis. The section for assessing the structural and functional state of lymphocytes in the development of acute pancreatitis by evaluating the blebbing of the plasma membrane of the cell is presented. It is intended for General surgeons, anesthesiologists, resuscitators, residents who are trained in the specialty "Surgery". It can be useful for doctors of other specialties and senior students of higher medical schools.
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Monteverde, C. A. Agroecosystem greenhouse gas balance indicator: Nitrous oxide component. Ottawa: Agriculture and Agri-Food Canada, 1997.

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3

Terrio, Paul J. Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin: Nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. [Washington, D.C.?]: U. S. Dept. of the Interior, U.S. Geological Survey, 1995.

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Terrio, Paul J. Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin: Nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. [Washington, D.C.?]: U. S. Dept. of the Interior, U.S. Geological Survey, 1995.

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Terrio, Paul J. Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin: Nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. [Washington, D.C.?]: U. S. Dept. of the Interior, U.S. Geological Survey, 1995.

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6

Terrio, Paul J. Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin: Nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. [Washington, D.C.?]: U. S. Dept. of the Interior, U.S. Geological Survey, 1995.

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7

Terrio, Paul J. Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin: Nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. [Washington, D.C.?]: U. S. Dept. of the Interior, U.S. Geological Survey, 1995.

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8

Terrio, Paul J. Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin: Nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. [Washington, D.C.?]: U. S. Dept. of the Interior, U.S. Geological Survey, 1995.

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9

Terrio, Paul J. Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin: Nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. [Washington, D.C.?]: U. S. Dept. of the Interior, U.S. Geological Survey, 1995.

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10

Canfield, Donald Eugene. Life before Oxygen. Princeton University Press, 2017. http://dx.doi.org/10.23943/princeton/9780691145020.003.0002.

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This chapter discusses the nature of life on ancient Earth before the evolution of oxygen production. It suggests that the Earth enjoyed an active and diverse biosphere well before the evolution of oxygen-producing cyanobacteria. This biosphere was fueled, mainly, by chemical compounds liberated during volcanism, underscoring again the importance of plate tectonics in shaping life on our planet. Geological evidence indicates that many of the processes that we have imagined were part of the early biosphere that was in place 3.5 billion years ago. These processes include methanogenesis, sulfate reduction, and decomposition of dead organic biomass, which was likely aided by a host of different fermenting bacteria. It seems likely, though, that this early biosphere was much less active than what we enjoy at present.

Частини книг з теми "Oxygen indicators":

1

Ranasinghe, J. A., and A. F. Holland. "Benthos as indicators of low summer dissolved oxygen in Chesapeake Bay." In Ecological Indicators, 1560–64. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-4661-0_76.

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Borisov, Sergey M., Michela Quaranta, and Ingo Klimant. "Indicators for optical oxygen sensors." In Advances in Chemical Bioanalysis, 1–70. Cham: Springer International Publishing, 2012. http://dx.doi.org/10.1007/11663_2013_1.

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Opitz, N., and D. W. Lübbers. "Blood Gas Analysis Using Fluorescence and Absorption Indicators in Optical Sensors (Optodes) with Integrated Excitation and Fluorescence Detection on Semiconductor Basis." In Oxygen Transport to Tissue X, 177–81. New York, NY: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4615-9510-6_20.

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Hoernes, S., and G. Voll. "Detrital Quartz and K-Feldspar in Quartzites as Indicators of Oxygen Isotope Exchange Kinetics." In Equilibrium and Kinetics in Contact Metamorphism, 315–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76145-4_15.

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Bakker, D. J. "Hyperbaric Oxygen Therapy: Past, Present and Future Indications." In Oxygen Transport to Tissue XIV, 95–105. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3428-0_8.

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Takahashi, H., and S. Kobayashi. "New Indications for Hyperbaric OxygenTherapy and Its Complication." In Hyperbaric Oxygen Therapy in Otorhinolaryngology, 1–13. Basel: KARGER, 1998. http://dx.doi.org/10.1159/000059049.

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Ichihara, Kazuo, and Yasushi Abiko. "Cardiac Metabolism as an Indicator of Oxygen Supply/Demand Ratio." In Oxygen Transport to Tissue X, 431–35. New York, NY: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4615-9510-6_51.

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Naumann, C. P., Y. A. Ruetsch, W. Fleckenstein, M. Fennema, W. Erdmann, and G. A. Zäch. "PO2-Profiles in Human Muscle Tissue as Indicator of Therapeutical Effect in Septic Shock Patients." In Oxygen Transport to Tissue XIV, 869–77. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3428-0_107.

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Simoni, Jan, Grace Simoni, and John F. Moeller. "ATP-Adenosine-GSH Crosslinked Hb, An Oxygen Carrier with Pharmacological Properties for Multiple Therapeutic Indications." In Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics, 315–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40717-8_17.

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Kime, Ryotaro, Masako Fujioka, Takuya Osawa, Shun Takagi, Masatsugu Niwayama, Yasuhisa Kaneko, Takuya Osada, Norio Murase, and Toshihito Katsumura. "Which Is the Best Indicator of Muscle Oxygen Extraction During Exercise Using NIRS?: Evidence that HHb Is Not the Candidate." In Oxygen Transport to Tissue XXXV, 163–69. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7411-1_23.

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Тези доповідей конференцій з теми "Oxygen indicators":

1

Ghosh, Ruby N., Reza Loloee, Sage P. Kramer, Per Askeland, and Christopher T. Weeks. "Oxygen detection via nanoscale optical indicators." In 2009 IEEE Sensors. IEEE, 2009. http://dx.doi.org/10.1109/icsens.2009.5398279.

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Baldini, Francesco, Mauro Bacci, Franco Cosi, Alessanro Del Bianco, and Anna M. Verga Scheggi. "Transition metal complexes as indicators for a fiber optic oxygen sensor." In OE Fiber 91, edited by Robert A. Lieberman. SPIE, 1992. http://dx.doi.org/10.1117/12.56535.

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Loloee, Reza, Per A. Askeland, and Ruby N. Ghosh. "Dissolved Oxygen Sensing in a Flow Stream using Molybdenum Chloride Optical Indicators." In 2007 IEEE Sensors. IEEE, 2007. http://dx.doi.org/10.1109/icsens.2007.4388675.

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Hebbale, Chandan, and Katherine Fu. "Wearable On-Demand Oxygen Therapy." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-59199.

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Oxygen concentration devices currently on the market have many shortcomings. They are bulky and difficult to carry. They alter a patient’s outward image with a visual mark of disability. They do not change oxygen delivery in any way to adjust to the patient’s health. They also lack indicators to help the patient decide when to begin or end a therapy session. Some patient’s decide not to take oxygen therapy as a result of these shortcomings. Those that use these devices may receive over oxygenation or under oxygenation due to the mentioned pitfalls. Any of the shortcomings described can be life threatening to the patient. The present innovation is a proposed system for oxygen delivery that adjusts flowrate based on the patient health and requires no user input to begin or end a therapy session. This paper presents a unique wearable device design for delivering oxygen in a pressure based concentration system.
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Fedyaeva, A. V., I. V. Lyubushkina, A. V. Stepanov, Y. Li, A. V. Sidorov, and E. G. Rikhvanov. "MITOCHONDRIAL MEMBRANE POTENTIAL AND REACTIVE OXYGEN SPECIES, AS INDICATORS OF STRESS STATUS OF PLANTS." In The All-Russian Scientific Conference with International Participation and Schools of Young Scientists "Mechanisms of resistance of plants and microorganisms to unfavorable environmental". SIPPB SB RAS, 2018. http://dx.doi.org/10.31255/978-5-94797-319-8-781-785.

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MISEVIČIENĖ, Stefanija. "CHANGES IN CONCENTRATIONS OF ORGANIC MATTER IN THE MOUTHS OF THE DOTNUVELE AND SMILGA RIVERS." In RURAL DEVELOPMENT. Aleksandras Stulginskis University, 2018. http://dx.doi.org/10.15544/rd.2017.095.

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The quality of water in rivers of central Lithuania is often bad due to intensive anthropogenic activities. When rivers flow through the town’s territory, concentrated pollution, such as rainwater, industrial and productional waste water discharges, contributes to diffuse sources of pollution. If biogenic substances are the main indicators for diffuse pollution, organic matter, expressed as BOD, is the indicator for concentrated pollution. The article provides the 2013 – 2017 monitoring data on the changes of organic matter in the water of the Dotnuvele and Smilga Rivers and discusses the reasons for fluctuations in concentrations of BOD7. The aim of the research is to investigate the changes in the organic matter of the Dotnuvele and Smilga Rivers, depending on meteorological factors. For chemical analysis, water samples were taken quarterly. Water analysis was carried out by the ASU Chemical Analytical Laboratory of Water Resources Engineering Institute. The amount of organic matter (BOD7) is calculated as the difference in oxygen content after 7 days of incubation, while the amount of dissolved oxygen (O2) in the water is determined by the electrochemical probe method. The concentrations of BOD7 and O2 in the water of both rivers is compared with the criteria for assessing the ecological status of surface water bodies. The research has shown that the dissolved oxygen concentrations in rivers’ water are strongly influenced by water temperature and precipitation. The lower the temperature, the more of the dissolved oxygen is found in rivers’ water (r = -0.64). A lower precipitation amount, which reaches the rivers, increases the amount of dissolved oxygen in them (r = -0.45). The increase of BOD7 concentrations in rivers’ water was caused by higher precipitation amount (r = 0.46), higher air (r = 0.41) and lower water temperature (r = -0.41). The ecological status of the Dotnuvele River was usually good, while Smilga was average.
7

Mirdamadi, Mahsa, Besharat Rahimi, Enayat Safavi, Hamidreza Abtahi та Soheil Peiman. "Increase in oxygen uptake to work rate increment (ΔVO2/ΔWR) during cardiopulmonary exercise testing: Correlation to COPD severity indicators, including BODE index". У Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2287.

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8

Xia, Chunguang, and Nicholas Fang. "Enhanced Mass Transport Through Permeable Polymer Microcirculatory Networks." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-15408.

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One of the obstacles of culturing functioning vital tissues in vitro is to obtain a substantial biomass at a physiological cell density (>108cells/cm3). At this high density, the diffusion length of metabolites is limited to ~100um. As a matter of fact, in real tissue, almost all the cells are located within 100um distance from the capillaries [1]. Studies [2, 3] also confirmed that the cells in the artificial tissue cannot be properly cultured when they are further than 400um from the external nutrient source. Therefore, to culture three dimensional artificial tissue with substantial biomass, vascularization is necessary to enhance the metabolites transport. The short diffusion length of the metabolites requires high capillary density (>100/mm2) in vascularization. To meet this need, we have developed a novel high resolution and high speed 3D microfabrication technique, the projection microstereolithography[4] to explore microcirculatory networks with high density (>150/mm2). Using this technology we designed and fabricated the microreactors as shown in Figure 1. In our samples, 800um PEG microcapillaries with 20um inner radius and 40um outer radius with pitch of 96um are fabricated. Two rings as inlet and outlet are connected to external supply of culture medium. We designed the parameters of the vascularized microbioreactor based on the simulations of oxygen and carbon dioxide transport and metabolism in hepatocytes. As shown in Figure 2, the capillaries are arranged in a hexagonal way. According to the geometric symmetry, the final simulation domain is divided into 2 regions, the polymer capillary wall and the tissue. We assumed that a culture media with dissolved oxygen is pumped through the capillaries at 1.5mm/s rate and diffuses through the capillary wall, into the hepatocytes. The consumption of oxygen follows Michaelis-Menten kinetics [5, 6] and the metabolic rate of carbon dioxide is assumed to be proportional to that of oxygen by a fixed quotient (-0.81) which is addressed and studied by other groups [7]. The carbon dioxide diffuses into the capillaries and can be carried away through the flow of the culture medium. Our simulation indicates that the bottleneck of effective oxygen transport is the permeability of the polymer materials. The oxygen concentration drops off about 90% after diffusing through the capillary wall. It is predicted that the diffusion length at the inlet is 74um and 48um at the outlet; the rapid drop of carbon dioxide concentration also happens across the capillary wall. The predicted carbon dioxide concentration in the tissue is ~80nmol/cm3; this value is much smaller than the toxic value (100mmHg or 3umol/cm3) reported by David Gray and coworkers [8]. In Figure 2, we present the effect of the permeability of the capillary polymer materials on the diffusion length of oxygen and the concentration of carbon dioxide in the tissue. Our study indicates the existence of an optimal permeability for the capillary network, at which the overall diffusion length of oxygen is maximized. Interestingly, we also found a maximum concentration of carbon dioxide in the cultured tissue as the permeability of the polymer material changes. We attribute it to the competition between the tissue thickness and the permeability. Higher permeability increases the cultured tissue thickness, and also increases the ability of capillary to empty carbon dioxide. Not only is this model applicable for oxygen and carbon dioxide, but also for the transport of other metabolites. As an ongoing experimental effort, our fluorescent microscopy measurement validated the diffusion transport of fluorescent species from the capillary (Figure 3). Experiments are also in progress on the oxygen diffusion from the capillaries will cell cultures of high density on the PEG scaffold by introducing proper indicators. In summary, we have established a method to design and manufacture vascularized microcirculatory network to enhance the mass transport during the tissue culture. To ensure the effective nutrient delivery and wastes removal, our numerical simulation also confirms that it is essential to embed high density microcapillaries with optimal permeability.
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Gonçalves, Gil, Sara Cabral, and António Paulo Lopes. "Predicting ambulatory oxygen indications with lung function tests." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.oa480.

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Chu, Bryan, Eklavya Singh, Johnson Samuel, and Nikhil Koratkar. "Graphene Oxide Colloidal Suspensions as Cutting Fluids for Micromachining: Part 1 — Fabrication and Performance Evaluation." In ASME 2015 International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/msec2015-9372.

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This paper is aimed at investigating the effects of graphene oxide platelet (GOP) geometry (i.e., lateral size and thickness) and oxygen functionalization on the cooling and lubrication performance of GOP colloidal suspensions. The techniques of thermal reduction and ultrasonic exfoliation were used to manufacture three different types of GOPs. For each of these three types of GOPs, colloidal solutions with GOP concentrations varying between 0.1–1 wt% were evaluated for their dynamic viscosity, thermal conductivity and micromachining performance. The ultrasonically-exfoliated GOPs (with 2–3 graphene layers and lowest in-solution characteristic lateral length of 120 nm) appear to be the most favorable for micromachining applications. Even at the lowest concentration of 0.1 wt%, they are capable of providing a 51% reduction in the cutting temperature and a 25% reduction in the surface roughness value over that of the baseline semi-synthetic cutting fluid. For the thermally-reduced GOPs (with 4–8 graphene layers and in-solution characteristic lateral length of 562–2780 nm), a concentration of 0.2 wt% appears to be optimal. The findings suggest that the differences seen between the colloidal suspensions in terms of their droplet spreading, evaporation and the subsequent GOP film-formation characteristics may be better indicators of their machining performance, as opposed to their bulk fluid properties.

Звіти організацій з теми "Oxygen indicators":

1

Basu, Sayani. Hyperbaric Oxygen Therapy: A Breakthrough in Healthcare. Science Repository Oü, December 2020. http://dx.doi.org/10.31487/sr.blog.22.

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The physiological and pharmacological benefits and high therapeutic response of hyperbaric oxygen therapy indicates that hyperbaric oxygen therapy offers promise in the treatment of a wide range of medical conditions.
2

Zhao, Dawen. Tumor Oxygen Dynamics as a Prognostic Indicator of Effective Antiangiogenic Therapy. Fort Belvoir, VA: Defense Technical Information Center, May 2003. http://dx.doi.org/10.21236/ada416721.

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3

Zhao, Dawen, and Ralph P. Mason. Tumor Oxygen Dynamics as a Prognostic Indicator of Effective Antiangiogenic Therapy. Fort Belvoir, VA: Defense Technical Information Center, May 2002. http://dx.doi.org/10.21236/ada407194.

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Water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin; nutrients, dissolved oxygen, and fecal-indicator bacteria in surface water, April 1987 through August 1990. US Geological Survey, 1995. http://dx.doi.org/10.3133/wri954005.

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