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Дисертації з теми "Oxytocin and Vasopressin"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 6 лютого 2022

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1

Lefebvre, Diana Lynn. "Extrahypothalamic vasopressin and oxytocin gene expression." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41031.

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Considerable evidence supports a role for vasopressin (VP) as a local regulator of steroidogenesis in rat testes. I show that rat testes contain three distinct VP gene-related transcripts differing in size from the hypothalamic VP mRNA. Two of these transcripts contain exons B and C, but not the exon that encodes the nonapeptide VP. Hence, these transcripts are incapable of generating testicular irVP. The third transcript possesses exon A-like sequences, probably originating from expression of a VP-related gene. This transcript may encode the VP-like peptide that has been detected in testicula

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2

MacLean, Evan L., Laurence R. Gesquiere, Margaret E. Gruen, Barbara L. Sherman, W. Lance Martin, and C. Sue Carter. "Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/625986.

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Aggressive behavior in dogs poses public health and animal welfare concerns, however the biological mechanisms regulating dog aggression are not well understood. We investigated the relationships between endogenous plasma oxytocin (OT) and vasopressin (AVP)-neuropeptides that have been linked to affiliative and aggressive behavior in other mammalian species-and aggression in domestic dogs. We first validated enzyme-linked immunosorbent assays (ELISAs) for the measurement of free (unbound) and total (free + bound) OT and AVP in dog plasma. In Experiment 1 we evaluated behavioral and neuroendocr

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3

McCurdy, Richard Douglas. "Postnatal growth of the porcine vasopressin/oxytocin-containing nucleus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ33252.pdf.

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4

Epton, Matthew James. "Somatic cross-over mutations between vasopressin and oxytocin genes." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365287.

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5

Gouin, Jean-Philippe. "MARITAL QUALITY AND PLASMA LEVELS OF OXYTOCIN AND VASOPRESSIN." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1236184248.

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6

Haley, Gwendolen E. "Contribution of neurokinin 3 receptor signaling to systemic vasopressin and oxytocin release." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1594497031&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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7

La-Borde, Penelope Jane. "Activation of the vasopressin and oxytocin receptor family : structural and mechanistic insights." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7639/.

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G-protein-coupled receptors (GPCRs) are major pharmaceutical drug targets due to their crucial role in cell signalling. The neurohypophysial peptide hormones [Arg⁸] vasopressin (AVP) and oxytocin (OT) signal through a subfamily of GPCRs, comprising the AVP receptors (V₁a R, V₁bR and V₂R) and the OT receptor (OTR). The aim of this work was to understand the molecular basis of receptor activation by defining exact contacts between agonist and receptor. Molecular modelling suggested that two conserved negatively-charged residues may be important for agonist binding and receptor activation. Intera

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8

Aulino, Elizabeth Ann Morningstar. "The Impact of the Oxytocin and Vasopressin Systems on Sex-Specific Brain Development." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent161965288538867.

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9

Karpenko, Iuliia. "Conception, synthesis and evaluation of fluorescent probes and PET radioligands for the oxytocin and vasopressin receptors." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF045/document.

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Les récepteurs de l’ocytocine (OTR) et de la vasopressine (AVPR) sont connus pour être impliqués dans la modulation d’effets centraux complexes. Récemment l’OTR a été proposé comme une cible thérapeutique pour le traitement des troubles du spectre autistique (TSA).Afin de mieux comprendre le rôle de l’OTR et des AVPR dans les TSA, d’éclaircir des nouveaux traits de sa pharmacologie et d’établir des méthodes du criblage sur les récepteurs sauvages, nous avons développé des traceurs pour la tomographie par émission des positons ainsi que des sondes fluorescentes pour la famille OT/AVP des RCPG.

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10

Linfoot, Ian. "Naturally occurring variations in defensive burying behavior are associated with differences in central neuropeptide expression in the male rat." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/793.

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The shock prod defensive burying test has proven incredibly reliable and instrumental in determining the underpinnings of normal anxiety in rodents. Largely ignored in tests of defensive burying, however, is the capacity for individual animals to display marked variations in active and passive coping behaviors. To unmask the neurobiological correlates of this behavioral differentiation, rats were exposed to a mousetrap that was remotely triggered upon approach to remove the quality of pain. This design invited striking variations in defensive burying behavior levels, in which some rats eith

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11

Bick, Johanna Renee. "Women's and children's neuropeptide production following physical interactions the role of biological relatedness /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 42 p, 2008. http://proquest.umi.com/pqdweb?did=1597633411&sid=7&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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12

Martinez, Luis A. "Neural Regulation of Sexual Solicitation in Female Syrian Hamsters: Role of Oxytocin." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/neurosci_diss/8.

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In most animal species, reproductive success depends critically on precopulatory or solicitational behaviors that occur prior to mating. The specific sensory systems and behavioral strategies employed in precopulatory behaviors vary across species; in all cases, however, animals must be able to identify potential mating partners and solicit sexual interest. Female Syrian hamsters (Mesocricetus auratus) engage in multiple forms of precopulatory behaviors that are preferentially expressed to males or their odors, including vaginal scent marking and sexual odor preference. Conspecific odors relev

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13

Velmurugan, Sathya. "Actions of appetite regulating peptides on supraoptic nucleus (SON) oxytocin neurones." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3938.

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Oxytocin has established roles in parturition and lactation, but can also be released in response to non-reproductive stimuli, such as hyperosmolarity and stress. As a majority of appetite regulating peptides activate the hypothalamo-pituitary-adrenal stress axis, and oxytocin is also a stress hormone in the rat, it was hypothesized that the oxytocin system in the neurohypophysial axis could be a target for appetite-regulating peptides of central and peripheral origin. The effects of central administration of neuropeptide Y (NPY; a central orexigenic peptide and a central and peripheral neurot

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14

MacLean, Evan L., Laurence R. Gesquiere, Nancy R. Gee, Kerinne Levy, W. Lance Martin, and C. Sue Carter. "Effects of Affiliative Human–Animal Interaction on Dog Salivary and Plasma Oxytocin and Vasopressin." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/625989.

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Oxytocin (OT) and vasopressin (AVP) are neuropeptides with diverse effects on social behavior, cognition and stress responses. Recent studies suggest that OT facilitates and responds to affiliative forms of human-animal interaction (HAI). However, previous studies measuring OT and AVP in dogs have been limited to measures from blood or urine, which present concerns related to the invasiveness of sample collection, the potential for matrix interference in immunoassays, and whether samples can be collected at precise time points to assess event-linked endocrine responses. Previous studies from o

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15

Grindstaff, Regina Rae Randolph. "Cardiopulmonary baroreceptor regulation of neurohypophysial hormones." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9988693.

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16

Caughey, Sarah Dawn. "Neuroendocrine control of maternal behaviour." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5956.

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Maternal behaviour during the peri-partum period, albeit in differing forms, can be observed in all mammals, thus it must serve an important evolutionary purpose in enabling the successful raising of offspring. Maternal behaviour is comprised of a large suite of behaviours; in rodents these are generally defined as lactation, pup retrieval, maternal aggression and pup grooming. The maternal behaviour circuitry involves many brain regions including the hypothalamus and the limbic system which work together to regulate the motor, motivational and emotional demands of the lactation period. The ma

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17

Sugita, Kenichiro, Masato Shibuya, Masakazu Takayasu, et al. "Role of Nitric Oxide in the Cerebral Vasodilatory Responses to Vasopressin and Oxytocin in Dogs." Thesis, Nature Publishing Group, 1993. http://hdl.handle.net/2237/16711.

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18

Guldenaar, S. E. F. "Questions about the localization of oxytocin and vasopressin in gonads and brain : Some answers fron immunocytochemistry." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375018.

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19

Lagumdzija, Alena. "The effects of some peptide hormones on osteoblast-like cells : with specific focus on oxytocin and vasopressin /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-197-0/.

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20

Rosso, Lia. "A study of pituicytes in primary culture : morphological plasticity, taurine release and implications for oxytocin and vasopressin output." Nice, 2004. http://www.theses.fr/2004NICE4015.

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L’ocytocine et la vasopressine sont synthétisées et sécrétées par les neurones du système hypothalamo-neurohypophysaire. Les éléments non-neuronaux les plus abondants du lobe neural sont les pituicytes, des cellules gliales spécialisées, qui jouent un rôle important dans la modulation de la sécrétion des deux neurohormones. En effet, dans des situations physiologiques qui nécessitent une augmentation de la sécrétion d’ocytocine et de vasopressine, les pituicytes modifient leur morphologie. Ces changements morphologiques sont comparables à l’étoilement en culture primaire. De plus, les pituicyt

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21

Monteiro, Olivia F. de S. "Mechanisms of dendritic peptide release." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4420.

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Magnocellular neurones (MCNs) are capable of secreting vasopressin and oxytocin from the somato-dendritic compartment, which can occur independently to secretion from nerve terminals. One hypothesis of the mechanism that regulates this differential release is that dendrites utilise different vesicle pools compared to those found in terminals. Little is known for the function of neuronal dendrites, especially the mechanism for peptide release. One theory is that vesicles stored in dendrites are non-released vesicles ready for recycling or degradation. Immunofluorescent labelling was performed o

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22

Witchey, Shannah K. "Mechanisms Important to the Neural Regulation of Maternal Behavior." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532954980720448.

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23

Blakeley, Hillary Joy Keele N. Bradley. "Functional roles of arg-vasopressin and oxytocin on cellular excitability in neurons of the rat lateral amygdala." Waco, Tex. : Baylor University, 2007. http://hdl.handle.net/2104/5127.

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24

Ho, Shuang-Bao. "Corticotropin-releasing factor-41 (CRF-41), arginine vasopressin (AVP) and oxytocin regulation in hypothalamic cells in culture." Thesis, Brunel University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306850.

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25

Coletti, Ricardo. "Participação do sulfeto de hidrogênio na manutenção da homeostase hidroeletrolítica em resposta à privação hídrica de 24 horas." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-28052018-165026/.

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A manutenção da osmolalidade e do volume dos líquidos extra- (LEC) e intracelular (LIC) são fatores de extrema importância à conservação da vida. Na desidratação (por ingestão insuficiente ou perda excessiva de água), sistemas de controle autonômicos e endócrinos são acionados frente à ativação de barorreceptores (periféricos) e osmorreceptores (centrais e periféricos), visando estimular a sede e inibir o apetite ao sódio, além de reduzir a diurese, promover a natriurese e contrair a musculatura lisa dos vasos. Especificamente para o sistema de controle endócrino é evidente que tais respostas

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26

Yuan, Jing Ting (Christine). "Sex Differences in Oxytocin and Vasopressin V1a Receptor Binding Densities in the Mouse Brain: Focus on the Social Behavior Neural Network." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107419.

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Thesis advisor: Alexa Veenema<br>Thesis advisor: Nicholas Worley<br>Oxytocin (OT) and vasopressin (AVP) often regulate social behaviors in sex-specific ways. We hypothesized that this could be mediated by sex differences in the OT receptor (OTR) and AVP V1a receptor (V1aR) in the brain. Here, we determined whether there are sex differences in OTR and V1aR binding densities in nodes of the social behavior neural network in the mouse brain. We also compared sex differences int he OTR and V1aR in the mouse brain with those found previously in the rat brain. Although mice and rats are closely rela

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27

Smith, Caroline Jackson. "Development of oxytocin, vasopressin V1a, and mu-opioid receptor expression in the rat brain: Implications for the regulation of juvenile social novelty-seeking behavior." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107311.

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Thesis advisor: Alexa H. Veemena<br>Across species, the juvenile period is characterized by increased social interaction with peers and heightened novelty-seeking behavior, as compared to any other life stage. These behaviors are likely to be highly adaptive during this developmental phase. Still, an excessive novelty-seeking phenotype may predispose individuals to risk-taking and substance abuse, while too little social engagement and low novelty-seeking are characteristics of neuropsychiatry disorders such as autism. The over-arching aim of this dissertation research has been to elucidate th

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28

Schorscher-Petcu, Ara. "Involvement of neuropeptides calcitonin gene-related peptide, vasopressin, and oxytocin in nociception and emotional reactivity in the mouse." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96900.

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In this study, the role of three neuropeptides, calcitonin gene-related peptide (CGRP), arginine vasopressin (AVP) and oxytocin (OXT), in pain-related behaviors was investigated. Using two strains of inbred mice exhibiting different CGRP expression levels, we had shown before that in the peripheral nervous system CGRP determines the threshold for thermal pain. Here, we extended this finding to the central nervous system. Moreover, the contribution of brain CGRP to the control of locomotion, anxiety- and depression-like behavior was investigated. Pharmacological manipulation of CGRP signaling

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29

Silva, Melina Pires da. "Modulação nitrérgica de canais para cátions ativados por hiperpolarização e nucleotídeo cíclico em neurônios do núcleo supraóptico." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-01062015-172223/.

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O núcleo supraóptico (SON), uma das várias áreas hipotalâmicas envolvidas no equilíbrio hidroeletrolítico corporal, é de suma importância na complexa rede de sistemas fisiológicos que atuam na manutenção da homeostase. Este núcleo é constituído por um grupamento de neurônios magnocelulares (MNCs) responsáveis pela síntese e liberação de vasopressina e ocitocina, neuropeptídios cujos principais efeitos se fazem sobre a excreção de água e sal pelos rins. Alterações da osmolalidade plasmática implicam em mudanças funcionais intrínsecas (propriedades de membrana) e extrínsecas (sinápticas) na exci

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30

Silva, Melina Pires da. "Modulação nitrérgica de canais para cátions ativados por hiperpolarização e nucleotídeo cíclico em neurônios do núcleo supraóptico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-06012016-162247/.

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O núcleo supraóptico (SON), uma das várias áreas hipotalâmicas envolvidas no equilíbrio hidroeletrolítico corporal, é de suma importância na complexa rede de sistemas fisiológicos que atuam na manutenção da homeostase. Este núcleo é constituído por um grupamento de neurônios magnocelulares (MNCs) responsáveis pela síntese e liberação de vasopressina e ocitocina, neuropeptídios cujos principais efeitos se fazem sobre a excreção de água e sal pelos rins. Alterações da osmolalidade plasmática implicam em mudanças funcionais intrínsecas (propriedades de membrana) e extrínsecas (sinápticas) na exci

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31

Blanks, Andrew Martin. "Investigation of the spatial and temporal expression of oxytocin and vasopressin in human intrauterine tissues during pregnancy and parturition." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250961.

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32

Yuan, Qiuju, and 袁秋菊. "The plasticity of hypothalamic magnocellular system following axonal damage by hypophysectomy in developing and adult rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30301117.

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33

Valesky, Eva [Verfasser]. "Oxytocin und Vasopressin als potentielle Verhaltensmodulatoren im Gehirn von Ratte und Graumull, Cryptomys anselli : Eine experimentelle immunhistochemische Untersuchung / Eva Valesky." Aachen : Shaker, 2005. http://d-nb.info/1181611768/34.

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34

Valesky, Eva Maria [Verfasser]. "Oxytocin und Vasopressin als potentielle Verhaltensmodulatoren im Gehirn von Ratte und Graumull, Cryptomys anselli : Eine experimentelle immunhistochemische Untersuchung / Eva Valesky." Aachen : Shaker, 2005. http://nbn-resolving.de/urn:nbn:de:101:1-2019032406561415954864.

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35

Vechiato, Fernanda Maria Veanholi. "Participação do sistema endocanabinóide nas respostas comportamentais, hormonais e neuronais induzidas pela sobrecarga salina." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-10082015-103622/.

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O sistema endocanabinóide (eCB) tem sido reconhecido como um importante modulador da homeostase energética e recentemente estudos o apontam como um possível integrador da homeostase hidroeletrolítica. Estudos recentes do nosso laboratório demonstraram a participação do receptor canabinóide do tipo 1 (CB1R) no controle da secreção neurohipofisária em resposta a expansão hipertônica do volume extracelular. Dessa forma, o presente trabalho visou esclarecer a participação do sistema eCB, particularmente do CB1R, nas respostas neuronais, neuroendócrinas e comportamentais induzidas pela sobrecarga s

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36

Flôr, Atalia Ferreira de Lima. "Participação da glia hipotalâmica na modulação das respostas neuroendócrinas, comportamentais e cardio-respiratórias induzidas pela angiotensina II no ventrículo lateral de ratos não anestesiados." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/8977.

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Submitted by Viviane Lima da Cunha (viviane@biblioteca.ufpb.br) on 2017-06-01T12:02:25Z No. of bitstreams: 1 arquivototal.pdf: 2264156 bytes, checksum: 5b49c1e05e29597d5088269704f06468 (MD5)<br>Made available in DSpace on 2017-06-01T12:02:25Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2264156 bytes, checksum: 5b49c1e05e29597d5088269704f06468 (MD5) Previous issue date: 2016-12-05<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The central Ang II (ANG II) induces neuroendocrine, behavioral and cardiovascular responses. Knowing that AT1 and AT2 receptors for AN

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37

Lima, Juliana Bezerra Medeiros de. "Participação das vias intracelulares moduladas pelo monóxido de carbono na regulação do equilíbrio hidroeletrolítico." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-07022019-140504/.

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O monóxido de carbono (CO) tem um importante papel na fisiologia animal incluindo plasticidade sináptica, processos de memória e aprendizagem, inflamação e liberação de neuropeptídios hipotalâmicos. Recentemente tem sido demonstrado que a liberação de vasopressina (AVP) e ocitocina (OT) em resposta a alterações no balanço hidromineral pode ser modulada por esse neuromodulador gasoso, contudo, os mecanismos pelos quais essa modulação ocorre ainda não foram elucidados. Nesse sentido, nós mapeamos possíveis alvos intracelulares do CO pelos quais esse gás poderia afetar as respostas neuroendócrina

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38

Bergström, Annika. "Dystocia in the bitch : epidemiology, aetiology and treatment /." Uppsala : Department of Clinical Sciences, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200942.pdf.

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39

Moura, Oliveira Vinícius Elias de [Verfasser], Inga D. [Akademischer Betreuer] Neumann, Mathias V. [Akademischer Betreuer] Schmidt, and Veronica [Akademischer Betreuer] Egger. "Neural mechanisms of female aggression: Implications on the oxytocin and vasopressin systems / Vinícius Elias de Moura Oliveira ; Inga D. Neumann, Mathias V. Schmidt, Veronica Egger." Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/1225121418/34.

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40

Moura, Oliveira Vinícius Elias de Verfasser], Inga D. [Akademischer Betreuer] [Neumann, Mathias V. [Akademischer Betreuer] Schmidt, and Veronica [Akademischer Betreuer] Egger. "Neural mechanisms of female aggression: Implications on the oxytocin and vasopressin systems / Vinícius Elias de Moura Oliveira ; Inga D. Neumann, Mathias V. Schmidt, Veronica Egger." Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/1225121418/34.

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41

Risberg, Anitha. "Hormones and fluid balance during pregnancy, labor and post partum." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107811.

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42

Borie, Amélie. "Régulation des comportements sociaux par l'action séquentielle de l'ocytocine et de la vasopressine dans le septum latéral." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT015/document.

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Contexte : L’ocytocine (OT) et la vasopressine (VP) modulent les comportements sociaux. Leurs rôles ont été étudiés indépendamment l’un de l’autre mais des effets combinatoires de ces deux peptides sont à envisager puisqu’ils sont tous les deux libérés au cours des comportements sociaux. Dans le septum latéral (SL), une structure cérébrale intégrant des informations sociales, l’ocytocine et la vasopressine sont libérées au cours des interactions sociales et modulent la reconnaissance ainsi que la discrimination sociale.Objectif : Comprendre la fonction duale de l’ocytocine et de la vasopressin

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43

Cottet, Martin. "Oligomérisation des récepteurs couplés au protéines G de la famille de la vasopressine et de l’ocytocine : mise en évidence dans les tissus natifs." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20030/document.

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Les récepteurs couplés aux protéines G forment une grande famille de récepteurs transmembranaires. De nombreuses études montrent que ces récepteurs présenteraient une tendance à interagir entre eux et à former des oligomères. Ces structures sont toutefois sujettes à controverse. En effet, très peu d'éléments permettent d'affirmer que ces oligomères existeraient dans les tissus natifs, la plupart des caractérisations se faisant en systèmes hétérologues. Nous avons donc développé une approche basée d'une part sur l'utilisation de ligands fluorescents pour marquer les récepteurs dans leur environ

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44

Oreland, Sadia. "Maternal Separation in the Rat : The Short- and Long-term effects of Early-life Experience on Neuropeptides, Monoamines and Voluntary Ethanol Consumption." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108678.

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Early-life experience has profound effects on the individual’s neurobiology and behaviour later in life. The rodent animal experimental model maternal separation (MS) was used to study this more in detail. The MS model involves short and prolonged postnatal separations simulating an emotionally safe and stressful environment, respectively. The aims of the thesis were to examine the impact of individual MS on ethanol consumption and on brain dopamine and serotonin systems in adult male rats. Furthermore, the influence of separation conditions on the short- and long-term consequences of MS on se

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45

Eaton, Jennifer Lynn. "The Molecular Control of Zebrafish Isotocin Cell Development: A Potential Model for the Neurodevelopmental Causes of Autism and Prader-Willi Syndrome." [Kent, Ohio] : Kent State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1152190826.

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Thesis (Ph.D.)--Kent State University, 2006.<br>Title from PDF t.p. (viewed Sept. 19, 2006). Advisor: Eric Glasgow. Keywords: oxytocin; isotocin; vasopressin; vasotocin; hypothalamo-neurohypophysial system; hypothalamus; development; autism; Prader-Willi Syndrome; single-minded; orthopedia; arylhydrocarbon nuclear translocator; Brn2; POU; zebrafish; behavior; paraventricular nucleus; supraoptic nucleus; preoptic nucleus; diencephalon; suprachiasmatic nucleus; thyroid transcription factor; sonic hedgehog; NK 2 transcription factor related; distal-less homeobox gene; homeobox; homeodomain; morph

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46

Röder, Konstantin. "Energy landscaping : on the relationship between functionality and sequence mutations for multifunctional biomolecules." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284922.

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The process of protein and RNA folding has been understood in general terms through the principle of minimal frustration, and is usually thought of as being guided by a folding funnel on the energy landscape, which is based around the native structure. However, more recently, various biomolecules have been associated with multifunnel energy landscapes, where each funnel exhibits a distinct structural ensemble and function. This work explores how the principle of minimal frustration may be extended to multifunnel energy landscapes that are associated with multifunctional biomolecules. To achiev

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47

Pflimlin, Elsa. "Conception et synthèse de sondes fluorescentes et d'agonistes des récepteurs de la vasopressine et de l'ocytocine : application mécanistique et thérapeutique." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAF055/document.

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Les récepteurs couplés aux protéines G constituent la plus grande famille de protéines membranaires et interviennent dans de nombreux processus physiologiques. La compréhension de l’interaction ligand-récepteur d’un point de vue mécanistique mais également thérapeutique est cruciale. Appartenant à la famille des récepteurs couplés aux protéines G, les récepteurs de la vasopressine et de l’ocytocine ont été choisis comme modèle d’étude. Ces hormones jouent un rôle important dans la modulation de l’attachement et de l’affect chez les mammifères. Afin d’accélérer la découverte de ligands ocytocin

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Ocampo, Daza Daniel. "Evolution of Vertebrate Endocrine and Neuronal Gene Families : Focus on Pituitary and Retina." Doctoral thesis, Uppsala universitet, Farmakologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-191829.

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The duplication of genes followed by selection is perhaps the most prominent way in which molecular biological systems gain multiplicity, diversity and functional complexity in evolution. Whole genome duplications (WGDs) therefore have the potential of generating an extraordinary amount of evolutionary innovation. It is now accepted that the vertebrate lineage has gone through two rounds of WGD in its early stages, after the divergence of invertebrate chordates and before the emergence of jawed vertebrates. These basal vertebrate WGDs are called 2R for two rounds of whole genome duplication. A

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Henriques, Thiago Pereira. "Provocação social na díade mãe-filhote: efeitos da ontogenia no comportamento social da prole." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/108935.

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As duas primeiras semanas de vida em ratos são críticas para o desenvolvimento, pois os animais são suscetíveis a influências ambientais. Diversos parâmetros neuroendócrinos e comportamentais podem ser influenciados, a curto e a longo prazo, pelas interações com a mãe, assim como por estressores. Entre esses estressores, um ambiente precoce socialmente aversivo pode alterar os comportamentos sociais, a ansiedade e as respostas neuroendócrinas ao estresse em adultos. O foco deste trabalho foi investigar o impacto do paradigma de provocação social na díade mãe-filhote sobre os comportamentos soc

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Saydoff, Joel Alan. "Brain serotonin osmoregulation of vasopressin and oxytocin." 1992. http://catalog.hathitrust.org/api/volumes/oclc/28687908.html.

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