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Статті в журналах з теми "PAMPs and DAMP"

Автор: Grafiati

Опубліковано: 10 березня 2023

Оновлено: 31 липня 2025

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1

Chen, Jiann Chu. "The complex of damage-associated molecular pattern and its inducer, pathogen-associated molecular pattern enhance triggering innate immunity in shrimp (VET1P.1128)." Journal of Immunology 194, no. 1_Supplement (2015): 146.16. http://dx.doi.org/10.4049/jimmunol.194.supp.146.16.

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Abstract Peptidoglycan (PG) derived commonly from Gram-positive bacteria, is one of pathogen-associated molecular pattern (PAMP). Incubating hemocytes of shrimp in PG caused degranulation, changes in cell size, reduction in the percentage of cell viability, necrosis of hemocytes, and released intracellular molecules containing damage-associated molecular pattern (DAMP) that is well known in mammals and teleosts. Incubating shrimp hemocytes in PAMP, DAMP or the mixture of PAMPs plus DAMPs all induced significant increases in phenoloxidase (PO) activity and respiratory burst (RB, release of supe

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2

Andersson, Ulf, Kevin J. Tracey, and Huan Yang. "Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation." Cells 10, no. 12 (2021): 3323. http://dx.doi.org/10.3390/cells10123323.

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High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both stimulating and inhibiting innate immunity. As reviewed here, HMGB1 is an oxidation-reduction sensitive DAMP bearing three cysteines, and the post-translational modification of these residues establishes its proinflammatory and anti-inflammatory activities by binding to different extracellular cell surface receptors. The redox-sensitive signaling mechanisms of HMGB1 also occupy an important niche in innate immunity because HMGB

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3

Jang, Gun-Young, Ji won Lee, Young Seob Kim, et al. "Interactions between tumor-derived proteins and Toll-like receptors." Experimental & Molecular Medicine 52, no. 12 (2020): 1926–35. http://dx.doi.org/10.1038/s12276-020-00540-4.

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AbstractDamage-associated molecular patterns (DAMPs) are danger signals (or alarmins) alerting immune cells through pattern recognition receptors (PRRs) to begin defense activity. Moreover, DAMPs are host biomolecules that can initiate a noninflammatory response to infection, and pathogen-associated molecular pattern (PAMPs) perpetuate the inflammatory response to infection. Many DAMPs are proteins that have defined intracellular functions and are released from dying cells after tissue injury or chemo-/radiotherapy. In the tumor microenvironment, DAMPs can be ligands for Toll-like receptors (T

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4

Zanoni, Ivan, and Marco Di Gioia. "Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation." Journal of Immunology 204, no. 1_Supplement (2020): 69.1. http://dx.doi.org/10.4049/jimmunol.204.supp.69.1.

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Abstract Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns (DAMPs) induce inflammatory gene expression. However, whether this symmetry in host responses between PAMPs and DAMPs extends to metabolic shifts is unclear. Here we report that the self-encoded oxidized phospholipid oxPAPC alters the metabolism of macrophages exposed to lipopolysaccharide

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5

Fowler, Teresa E., Vivek Choudhary, Samuel Melnyk, et al. "Dioleoylphosphatidylglycerol Inhibits Heat Shock Protein B4 (HSPB4)-Induced Inflammatory Pathways In Vitro." International Journal of Molecular Sciences 24, no. 6 (2023): 5839. http://dx.doi.org/10.3390/ijms24065839.

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Our previous work shows that dioleoylphosphatidylglycerol (DOPG) accelerates corneal epithelial healing in vitro and in vivo by unknown mechanisms. Prior data demonstrate that DOPG inhibits toll-like receptor (TLR) activation and inflammation induced by microbial components (pathogen-associated molecular patterns, PAMPs) and by endogenous molecules upregulated in psoriatic skin, which act as danger-associated molecular patterns (DAMPs) to activate TLRs and promote inflammation. In the injured cornea, sterile inflammation can result from the release of the DAMP molecule, heat shock protein B4 (

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6

Jiménez-Hernández, Alejandra, Ireri Alejandra Carbajal-Valenzuela, Irineo Torres-Pacheco, et al. "Extracellular DNA as a Strategy to Manage Vascular Wilt Caused by Fusarium oxysporum in Tomato (Solanum lycopersicum L.) Based on Its Action as a Damage-Associated Molecular Pattern (DAMP) or Pathogen-Associated Molecular Pattern (PAMP)." Plants 13, no. 21 (2024): 2999. http://dx.doi.org/10.3390/plants13212999.

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Vascular wilt is an important tomato disease that affects culture yields worldwide, with Fusarium oxysporum (F.o) being the causal agent of this infection. Several management strategies have lost effectiveness due to the ability of this pathogen to persist in soil and its progress in vascular tissues. However, nowadays, research has focused on understanding the plant defense mechanisms to cope with plant diseases. One recent and promising approach is the use of extracellular DNA (eDNA) based on the ability of plants to detect their self-eDNA as damage-associated molecular patterns (DAMPs) and

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7

Idrus, Hasta Handayani, Mochammad Hatta, Vivien Novarina Kasim, et al. "Molecular Impact on High Motility Group Box-1 (HMGB-1) in Pamps and Damp." Indian Journal of Public Health Research & Development 10, no. 8 (2019): 1109. http://dx.doi.org/10.5958/0976-5506.2019.02045.x.

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8

Shamilov, Rambon, Tyler W. Ackley, and Brian J. Aneskievich. "Enhanced Wound Healing- and Inflammasome-Associated Gene Expression in TNFAIP3-Interacting Protein 1- (TNIP1-) Deficient HaCaT Keratinocytes Parallels Reduced Reepithelialization." Mediators of Inflammation 2020 (April 21, 2020): 1–14. http://dx.doi.org/10.1155/2020/5919150.

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TNIP1 protein is a widely expressed, cytoplasmic inhibitor of inflammatory signaling initiated by membrane receptors such as TLRs which recognize pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Keratinocyte TNIP1 deficiency sensitizes cells to PAMPs and DAMPs promoting hyperresponsive expression and secretion of cytokine markers (e.g., IL-8 and IL-6) relevant to cases of chronic inflammation, like psoriasis, where TNIP1 deficiency has been reported. Here, we examined the impact of TNIP1 deficiency on gene expression and cellular responses (migration and viabilit

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9

Negishi, Hideo, Nobuyasu Endo, Yuki Nakajima, et al. "Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis." Proceedings of the National Academy of Sciences 116, no. 47 (2019): 23653–61. http://dx.doi.org/10.1073/pnas.1915326116.

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The activation of innate immune receptors by pathogen-associated molecular patterns (PAMPs) is central to host defense against infections. On the other hand, these receptors are also activated by immunogenic damage-associated molecular patterns (DAMPs), typically released from dying cells, and the activation can evoke chronic inflammatory or autoimmune disorders. One of the best known receptors involved in the immune pathogenesis is Toll-like receptor 7 (TLR7), which recognizes RNA with single-stranded structure. However, the causative DAMP RNA(s) in the pathogenesis has yet to be identified.

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10

Dwyer, Gaelen K., Lisa Mathews, Anna Lucas, et al. "IL-33 upregulated in fibroblastic reticular cells after recipient conditioning acts as a novel costimulatory signal in the generation of alloreactive Type 1 T helper cells." Journal of Immunology 208, no. 1_Supplement (2022): 175.08. http://dx.doi.org/10.4049/jimmunol.208.supp.175.08.

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Abstract In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs) that generate pro-inflammatory antigen-presenting cells (APC) that secrete IL-12 to initiate donor Type 1 T helper (Th1) responses causing graft-vs-host-disease (GVHD). Yet, other mechanisms exist to initiate alloimmune responses, as recipients with disrupted APC PAMP/DAMP signaling or lacking IL-12 develop GVHD. We used IL-33 receptor, ST2, deficient B6 mice as T cell donors into BALB/c recipients to test the hypothesis

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11

Scalfone, Lisa K., Hendrik J. Nel, Lucille F. Gagliardo, et al. "Participation of MyD88 and Interleukin-33 as Innate Drivers of Th2 Immunity to Trichinella spiralis." Infection and Immunity 81, no. 4 (2013): 1354–63. http://dx.doi.org/10.1128/iai.01307-12.

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ABSTRACTTrichinella spiralisis a highly destructive parasitic nematode that invades and destroys intestinal epithelial cells, injures many different tissues during its migratory phase, and occupies and transforms myotubes during the final phase of its life cycle. We set out to investigate the role in immunity of innate receptors for potential pathogen- or danger-associated molecular patterns (PAMPs or DAMPs). Focusing on the MyD88-dependent receptors, which include Toll-like receptors (TLRs) and interleukin-1 (IL-1) family members, we found that MyD88-deficient mice expelled worms normally, wh

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12

Kumar, Vijay, and John H. Stewart. "cGLRs Join Their Cousins of Pattern Recognition Receptor Family to Regulate Immune Homeostasis." International Journal of Molecular Sciences 25, no. 3 (2024): 1828. http://dx.doi.org/10.3390/ijms25031828.

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Pattern recognition receptors (PRRs) recognize danger signals such as PAMPs/MAMPs and DAMPs to initiate a protective immune response. TLRs, NLRs, CLRs, and RLRs are well-characterized PRRs of the host immune system. cGLRs have been recently identified as PRRs. In humans, the cGAS/STING signaling pathway is a part of cGLRs. cGAS recognizes cytosolic dsDNA as a PAMP or DAMP to initiate the STING-dependent immune response comprising type 1 IFN release, NF-κB activation, autophagy, and cellular senescence. The present article discusses the emergence of cGLRs as critical PRRs and how they regulate

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13

Hirai, K., H. Furusho, N. Kawashima, et al. "Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4." Journal of Dental Research 98, no. 1 (2018): 117–25. http://dx.doi.org/10.1177/0022034518796456.

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In the current concept of bacterial infections, pathogen-associated molecular patterns (PAMPs) derived from pathogens and damage-associated molecular patterns (DAMPs) released from damaged/necrotic host cells are crucial factors in induction of innate immune responses. However, the implication of DAMPs in apical and marginal periodontitis is unknown. Serum amyloid A (SAA) is a DAMP that is involved in the development of various chronic inflammatory diseases, such as rheumatoid arthritis. In the present study, we tested whether SAA is involved in the pathogenesis of periapical lesions, using hu

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14

Artemyeva, O. V., and L. V. Gankovskaya. "Inflammaging as the basis of age-associated diseases." Medical Immunology (Russia) 22, no. 3 (2020): 419–32. http://dx.doi.org/10.15789/1563-0625-iat-1938.

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Aging is one of the most complex biological phenomena that affects all human physiological systems, including the immune system. Immunosenescence is understood as structural and functional changes in both adaptive and innate immunity systems. The so-called inflammaging is among manifestations of immune aging. It is an age-related increase in inflammatory mediators and development of an inflammatory phenotype. An important role in development of inflammaging is assigned to chronic stimulation of immune system by exogenous and endogenous danger signals (pathogen-associated molecular pattern, PAM

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15

Mertowski, Sebastian, Ewelina Grywalska, Jarosław Ludian, et al. "The significance of Toll-like receptors in selected nephropathies." Diagnostyka Laboratoryjna 55, no. 2 (2019): 107–12. http://dx.doi.org/10.5604/01.3001.0013.7445.

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The diseases associated with kidney damage are an increasingly common problem in modern society and complications of chronic renal failure can result in death. Research conducted by many scientific centers, both Polish and foreign, concern the search for possible factors involved in the pathogenesis of glomerulonephritis. One of the possible causes of nephropathy may include the dysfunction of Toll-like receptors (TLRs), which constitute a “bridge” between innate and acquired response. TLRs are involved in receiving signals related to pathogen associated molecular patterns (PAMPs) as well as r

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16

Yang, Huan, Haichao Wang, Zhongliang Ju, et al. "MD-2 is required for disulfide HMGB1–dependent TLR4 signaling." Journal of Experimental Medicine 212, no. 1 (2015): 5–14. http://dx.doi.org/10.1084/jem.20141318.

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Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its extracellular functions. Previously, it was unknown how the TLR4 signalosome distinguished between HMGB1 isoforms. Here we demonstrate that the extracellular TLR4 adaptor, myeloid differentiation factor 2 (MD-2), binds specifically to the cytokine-inducing disulfide isoform of HMGB1, to the excl

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17

Wang, Yifei, та Robert J. Binder. "CD91-Dependent Release of IL-1β by GP96 Involves the Activation of the Inflammasome Complex". Journal of Immunology 198, № 1_Supplement (2017): 151.23. http://dx.doi.org/10.4049/jimmunol.198.supp.151.23.

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Abstract The immunogenic heat shock protein, gp96, binds to CD91 to elite an immune response, characterized by cross-presentation of chaperoned peptides and release of cytokines, including IL-1β. IL-1β is pro-inflammatory cytokine, which is secreted by immune cells upon sensing pathogen associated molecular pattern (PAMP) or damage associated molecular pattern (DAMP). IL-1β is synthesized as a precursor protein, and requires cleavage by Caspase-1 to the matured IL-1β which is released from the cells. Caspase-1 activation requires the inflammasome protein complex. For Inflammasome activation, s

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18

Pandya, Unnati, Chinaza Egbuta, Trefa Abdullah Norman, et al. "The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide." International Journal of Molecular Sciences 20, no. 2 (2019): 408. http://dx.doi.org/10.3390/ijms20020408.

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The endoplasmic reticulum (ER) chaperone protein, calreticulin (CRT), is essential for proper glycoprotein folding and maintaining cellular calcium homeostasis. During ER stress, CRT is overexpressed as part of the unfolded protein response (UPR). In addition, CRT can be released as a damage-associated molecular pattern (DAMP) molecule that may interact with pathogen-associated molecular patterns (PAMPs) during the innate immune response. One such PAMP is lipopolysaccharide (LPS), a component of the gram-negative bacterial cell wall. In this report, we show that recombinant and native human pl

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19

Germoglio, Marcello, Adele Adamo, Guido Incerti, et al. "Self-DNA Exposure Induces Developmental Defects and Germline DNA Damage Response in Caenorhabditis elegans." Biology 11, no. 2 (2022): 262. http://dx.doi.org/10.3390/biology11020262.

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All organisms, from bacteria to mammals, sense and respond to foreign nucleic acids to fight infections in order to survive and preserve genome integrity across generations. The innate immune system is an evolutionarily conserved defence strategy. Complex organisms have developed various cellular processes to respond to and recognise not only infections, i.e., pathogen-associated molecular patterns (PAMPs), but also to sense injury and tissue dysfunctions, i.e., damage-associated molecular patterns (DAMPs). Mis-localized self-DNA can be sensed as DAMP by specific DNA-sensing pathways, and self

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20

Iurescia, Sandra, Daniela Fioretti, and Monica Rinaldi. "The Innate Immune Signalling Pathways: Turning RIG-I Sensor Activation against Cancer." Cancers 12, no. 11 (2020): 3158. http://dx.doi.org/10.3390/cancers12113158.

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Over the last 15 years, the ability to harness a patient’s own immune system has led to significant progress in cancer therapy. For instance, immunotherapeutic strategies, including checkpoint inhibitors or adoptive cell therapy using chimeric antigen receptor T-cell (CAR-T), are specifically aimed at enhancing adaptive anti-tumour immunity. Several research groups demonstrated that adaptive anti-tumour immunity is highly sustained by innate immune responses. Host innate immunity provides the first line of defence and mediates recognition of danger signals through pattern recognition receptors

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21

Semenova, I. B. "ROLE OF PURINERGIC RECEPTORS IN IMMUNE RESPONSE." Journal of microbiology, epidemiology and immunobiology, no. 2 (April 28, 2016): 107–19. http://dx.doi.org/10.36233/0372-9311-2016-2-107-119.

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Purine receptors are located on immune and somatic cells of animal and human organisms. Summation of signals from purine and TOLL-like receptors takes place on the level of inflammasome formation and results in summation of the first and second signals of innate immunity. The first signal - from PAMPs (pathogen associated molecular patterns), the second - from DAMPs (danger associated molecular patterns). Adenosine triphosphate (ATP) is the most studied DAMP. ATP connects with purine receptors, which include P2 (P2X7 receptors are the best described), that results in opening of channels of the

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22

Tokarz-Deptuła, Beata, Łukasz Baraniecki, Joanna Palma, Michał Stosik, and Wiesław Deptuła. "Characterization of Platelet Receptors and Their Involvement in Immune Activation of These Cells." International Journal of Molecular Sciences 25, no. 23 (2024): 12611. http://dx.doi.org/10.3390/ijms252312611.

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The article characterises platelets, pointing out the role and contribution of their numerous receptors determining their specific and broad immune activity. Three types of platelet receptors are described, that is, extracellular and intracellular receptors—TLR (toll-like receptors), NLR (NOD-like receptor), and RLR (RIG-I-like receptor); extracellular receptors—selectins and integrins; and their other extracellular receptors—CLR (C-type lectin receptor), CD (cluster of differentiation), TNF (tumour necrosis factor), among others. Outlining the contribution of these numerous platelet receptors

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23

Dosch, Michel Ernest, Tamara Salamanca, Djulia Djonova, et al. "Could Connexin 43 dependent ATP release represent a new therapeutic target for sepsis?" Journal of Immunology 198, no. 1_Supplement (2017): 125.32. http://dx.doi.org/10.4049/jimmunol.198.supp.125.32.

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Abstract During sepsis, ATP is released into the extracellular space where it modulates immune response via specific receptors and ectonucleotidases present on various immune cells. ATP can be released by hemichannel Connexin 43 (Cx43). Here, we examine the importance of Cx43 mediated ATP release in macrophages and the role of this pathway in modulating innate immune responses in the context of sepsis. For murine sepsis model, caecal ligation and puncture (CLP) was used. Mice were treated with Gap27, a Cx43 inhibitor. Liver, lung, spleen, bone marrow, peritoneal fluid and blood cells expressin

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24

Trova, Sandro, Matthew Fenton, Bhavini Chauhan, et al. "Human and Pathogen Derived Ndpks Act As Novel Damps and PAMPs to Drive Leukemia Cell Survival and Progression through Signaling Via the TLR4-Mediated Alternative NLRP3 Inflammasome Pathway." Blood 134, Supplement_1 (2019): 2684. http://dx.doi.org/10.1182/blood-2019-131236.

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Elevated plasma levels of the nucleoside diphosphate kinase (NDPK) NM23-H1 are associated with poorer prognosis in acute myeloid leukemia (AML). We previously demonstrated that leukemic blasts release NM23-H1, which binds to more differentiated myeloid cells inducing their secretion of inflammatory cytokines, including IL-1β, that promote survival and proliferation of leukemic blasts1. Both AML and myelodysplastic syndrome (MDS) patients are prone to infections due to impaired hematopoiesis that is worsened by treatment. NDPKs are highly evolutionarily conserved raising the possibility that ba

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25

Mengis, Tamara, Laura Bernhard, Andrea Nüesch, et al. "The Expression of Toll-like Receptors in Cartilage Endplate Cells: A Role of Toll-like Receptor 2 in Pro-Inflammatory and Pro-Catabolic Gene Expression." Cells 13, no. 17 (2024): 1402. http://dx.doi.org/10.3390/cells13171402.

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Introduction: The vertebral cartilage endplate (CEP), crucial for intervertebral disc health, is prone to degeneration linked to chronic low back pain, disc degeneration, and Modic changes (MC). While it is known that disc cells express toll-like receptors (TLRs) that recognize pathogen- and damage-associated molecular patterns (PAMPs and DAMPs), it is unclear if CEP cells (CEPCs) share this trait. The CEP has a higher cell density than the disc, making CEPCs an important contributor. This study aimed to identify TLRs on CEPCs and their role in pro-inflammatory and catabolic gene expression. M

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26

Herwald, Heiko, and Arne Egesten. "On PAMPs and DAMPs." Journal of Innate Immunity 8, no. 5 (2016): 427–28. http://dx.doi.org/10.1159/000448437.

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27

Merkushova, E. D., E. M. Khasanova, and L. V. Gankovskaya. "Mechanisms of innate immunity in pathogenesis of psoriasis: approaches to targeted therapy." Medical Immunology (Russia) 22, no. 3 (2020): 449–58. http://dx.doi.org/10.15789/1563-0625-moi-1949.

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Psoriasis is a chronic auto-inflammatory, genetically determined dermatosis, being multifactorial by origin, characterized by hyperproliferation of epidermis, affected keratinocyte differentiation and inflammatory reaction in dermis. The disease is characterized by a tendency to spread over the area of lesion, and involvement of articular tissue in the pathological process, which significantly affects the living standards of patients and causes their disability. There are many provoking factors that contribute to occurrence of psoriasis, or progression of existing psoriatic process in individu

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28

Matsuoka, K., S. Dave, J. Tilstra, et al. "PAMPs and DAMPs in IBD." Inflammatory Bowel Diseases 13, supplement (2007): 643. http://dx.doi.org/10.1097/00054725-200705001-00003.

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29

Matsuoka, K., S. Davé, J. Tilstra, et al. "PAMPs and DAMPs in IBD." Inflammatory Bowel Diseases 13 (May 2007): 643. http://dx.doi.org/10.1097/00054725-200705005-00003.

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30

Foley, John F. "Blocking DAMPs but not PAMPs." Science Signaling 8, no. 360 (2015): ec13-ec13. http://dx.doi.org/10.1126/scisignal.aaa6950.

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31

Lee, Chih-Chun, Chun-Yu Tung, Ching Ching Wu, and Tsang Long Lin. "AVIAN INNATE IMMUNITY WITH AN EMPHASIS ON CHICKEN MELANOMA DIFFERENTIATION-ASSOCIATED GENE 5 (MDA5)." Taiwan Veterinary Journal 45, no. 03 (2019): 43–55. http://dx.doi.org/10.1142/s1682648519300016.

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Avian species have immune system to fight invading pathogens. The immune system comprises innate and adaptive immunity. Innate immunity relies on pattern recognition receptors to sense particular molecules present in pathogens, i.e. pathogen-associated molecular patterns (PAMPs), or danger signals in the environment, i.e. danger-associated molecular patterns (DAMPs). Cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) and nucleotide-binding oligomerization domain-like receptors (NLRs) are the sensors recognizing cytoplasmic PAMP and/or DAMP. Among common avian species, chi

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32

Cicchinelli, Sara, Giulia Pignataro, Stefania Gemma, et al. "PAMPs and DAMPs in Sepsis: A Review of Their Molecular Features and Potential Clinical Implications." International Journal of Molecular Sciences 25, no. 2 (2024): 962. http://dx.doi.org/10.3390/ijms25020962.

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Sepsis is a serious organ dysfunction caused by a dysregulated immune host reaction to a pathogen. The innate immunity is programmed to react immediately to conserved molecules, released by the pathogens (PAMPs), and the host (DAMPs). We aimed to review the molecular mechanisms of the early phases of sepsis, focusing on PAMPs, DAMPs, and their related pathways, to identify potential biomarkers. We included studies published in English and searched on PubMed® and Cochrane®. After a detailed discussion on the actual knowledge of PAMPs/DAMPs, we analyzed their role in the different organs affecte

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ITO, Takashi. "PAMPs/DAMPs as novel mediators of inflammation-associated thrombosis." Japanese Journal of Thrombosis and Hemostasis 24, no. 6 (2013): 675–79. http://dx.doi.org/10.2491/jjsth.24.675.

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Zindel, Joel, and Paul Kubes. "DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation." Annual Review of Pathology: Mechanisms of Disease 15, no. 1 (2020): 493–518. http://dx.doi.org/10.1146/annurev-pathmechdis-012419-032847.

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Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic breakthroughs. However, many inflammatory pathologies remain without specific therapy. This review discusses leukocytes in the context of sterile inflammation, a process caused by sterile (non-microbial) molecules, comprising damage-associated molecular patterns (DAMPs). DAMPs bind specific receptors to activate inflammation and start a highly optimized sequence of immune cell recruitment of neutrophils and monocytes to initiate effective tissue repair. When DAMPs are cleared, the recruited leukocytes c

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35

Chain, Robert, Linda Varghese, and Stefania Gallucci. "Role of PAMPs and DAMPs in Graft Rejection (126.6)." Journal of Immunology 188, no. 1_Supplement (2012): 126.6. http://dx.doi.org/10.4049/jimmunol.188.supp.126.6.

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Abstract Dendritic cells (DCs) induce immunity or tolerance depending on the presence of danger signals. LPS is a danger signal with multiple effects on DCs, besides activation. Unpublished results from our lab show that LPS induces DC death in vitro and in vivo. It has also been reported that DCs treated with LPS during their development remained immature and induced T cell anergy. LPS triggers TLR4, a PRR also stimulated by endogenous danger signals, like HMGB1, released during tissue damage. We used a mouse transplant model to determine the effects of simultaneous exposure to LPS and endoge

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36

Tang, Daolin, Rui Kang, Carolyn B. Coyne, Herbert J. Zeh, and Michael T. Lotze. "PAMPs and DAMPs: signal 0s that spur autophagy and immunity." Immunological Reviews 249, no. 1 (2012): 158–75. http://dx.doi.org/10.1111/j.1600-065x.2012.01146.x.

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Gentile, Lori F., and Lyle L. Moldawer. "DAMPs, PAMPs, and the Origins of SIRS in Bacterial Sepsis." Shock 39, no. 1 (2013): 113–14. http://dx.doi.org/10.1097/shk.0b013e318277109c.

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38

Bianchi, Marco E. "DAMPs, PAMPs and alarmins: all we need to know about danger." Journal of Leukocyte Biology 81, no. 1 (2006): 1–5. http://dx.doi.org/10.1189/jlb.0306164.

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39

Pisetsky, David S. "The origin and properties of extracellular DNA: From PAMP to DAMP." Clinical Immunology 144, no. 1 (2012): 32–40. http://dx.doi.org/10.1016/j.clim.2012.04.006.

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ITO, Takashi, and Ikuro MARUYAMA. "Thrombus formation and innate immunity." Japanese Journal of Thrombosis and Hemostasis 23, no. 3 (2012): 241–46. http://dx.doi.org/10.2491/jjsth.23.241.

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41

Toubai, Tomomi, Corinne Rossi, Katherine Oravecz-Wilson, et al. "Donor T Cells Intrinsic Responses to Damps Regulated By Siglec-G-CD24 Axis Mitigate Gvhd but Maintain GVL in Experimental BMT Model." Blood 126, no. 23 (2015): 229. http://dx.doi.org/10.1182/blood.v126.23.229.229.

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Abstract Innate immune receptors like pattern recognition receptors (PRRs) including toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD) like-receptors (NLR) on immune cells play an important role in initiating inflammatory responses to damage- and pathogen- associated molecular patterns (DAMPs and PAMPs) expressed on invading pathogens or released from damaged cells. Although it is well known that DAMPs directly modulate innate immune functions, it is less clear whether DAMPs directly regulate T cell intrinsic function. Members of the sialic acid binding Ig-like lec

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42

Miyaji, E. N., E. Carvalho, M. L. S. Oliveira, I. Raw, and P. L. Ho. "Trends in adjuvant development for vaccines: DAMPs and PAMPs as potential new adjuvants." Brazilian Journal of Medical and Biological Research 44, no. 6 (2011): 500–513. http://dx.doi.org/10.1590/s0100-879x2011000600003.

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43

Hetmann, Anna, and Stanisław Kowalczyk. "Receptory błonowe wiążące cząsteczki typu MAMP/PAMP i DAMP aktywujące pierwszą linię obrony lokalnej układu odpornościowego roślin." Postępy Biochemii 64, no. 1 (2018): 29–45. http://dx.doi.org/10.18388/pb.2018_103.

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Rośliny w toku ewolucji wykształciły wielopoziomowy układ odpornościowy przeciwdziałający infekcjom oraz zapobiegający rozwojowi chorób. Pierwszą linię obrony aktywują receptory błonowe, określane jako receptory rozpoznające wzorce molekularne obcych cząsteczek (PRR), wiążące cząsteczki typu MAMP/PAMP lub DAMP. Receptory typu PRR aktywują kaskady sygnałowe uruchamiające odpowiedzi obronne tworzące odporność aktywowaną przez cząsteczki PAMP (PTI). Odpowiedzi obronne współtworzące pierwszą linię obrony obejmują m. in. produkcję aktywnych form tlenu i tlenku azotu, odkładanie kalozy, zamykanie ap

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44

Bhatia, Nitish, Benu George, Daljeet Masih, Mohd Masih Uzzaman Khan, and Priya Malik. "Mechanistic insights into PAMP and DAMP driven activation of NETosis in autoimmune disorders." International Immunopharmacology 162 (September 2025): 115149. https://doi.org/10.1016/j.intimp.2025.115149.

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45

Arias Arroyo, Gladys C. "Centenario del nacimiento de María Reiche Neumann «La dama del desierto»." Ciencia e Investigación 6, no. 1 (2003): 40–42. http://dx.doi.org/10.15381/ci.v6i1.3315.

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Desde hace miles de años es castigada con furia por el viento, el sol la quema sin clemencia y la lluvia casi no se asoma, solamente las estrellas están presentes centellando todas las noches: la pampa de Nazca, sobre cuya superficie se observa trazadas líneas y otros dibujos que son visible únicamente desde el cielo y que hoy son conocidas como las líneas de Nazca.

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Pineda, Benjamin. "PAMP-DAMPs interactions mediates development and progression of multiple sclerosis." Frontiers in Bioscience 8, no. 1 (2016): 13–28. http://dx.doi.org/10.2741/s443.

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Liebers, V., T. Brüning, and M. Raulf. "Molekulare Muster und Immunsystem – PAMPs, MAMPs, DAMPs: Was ist relevant für Allergien und (berufliche) Atemwegserkrankungen?" Allergologie 38, no. 12 (2015): 604–10. http://dx.doi.org/10.5414/alx01818.

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Wakefield, D., P. Gray, J. Chang, N. Di Girolamo, and P. McCluskey. "The role of PAMPs and DAMPs in the pathogenesis of acute and recurrent anterior uveitis." British Journal of Ophthalmology 94, no. 3 (2009): 271–74. http://dx.doi.org/10.1136/bjo.2008.146753.

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Ludgate, Charles M. "Optimizing Cancer Treatments to Induce an Acute Immune Response: Radiation Abscopal Effects, PAMPs, and DAMPs." Clinical Cancer Research 18, no. 17 (2012): 4522–25. http://dx.doi.org/10.1158/1078-0432.ccr-12-1175.

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50

Holtick, Udo, Nela Klein-Gonzalez, and Michael S. von Bergwelt-Baildon. "Potential of Toll-like receptor 9 agonists in combined anticancer immunotherapy strategies: synergy of PAMPs and DAMPs?" Immunotherapy 3, no. 3 (2011): 301–4. http://dx.doi.org/10.2217/imt.10.118.

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