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Дисертації з теми "Pathogenic"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Panagoda, Gehan Joseph. "Pathogenic features of Candida parapsilosis : an emerging fungal pathogen /." Thesis, Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20377770.

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2

Collingwood, Charlotte Rose. "Pathogenomic characterisation of a novel, layer-associated Avian Pathogenic Escherichia coli." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3007233/.

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Avian Pathogenic Escherichia coli (APEC) is an important pathogen of the poultry industry, responsible for 43% of condemnations of broiler birds at slaughter and annual losses of between 1-8% of a laying flock. APEC is also a public health concern; consumption of poultry meat has been linked with urinary tract infections (UTI) in humans, and also as a reservoir of potential antimicrobial resistance genes. In this study of strain 3770, a reproductive tract associated isolate of APEC, the isolate was characterised for typical APEC virulence phenotypes, and also underwent full-genome sequencing i

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3

Florea, Florina [Verfasser], and Cassian [Akademischer Betreuer] Sitaru. "Pathogenic autoimmunity against skin laminins = Pathogene Autoimunität gegen Laminine der Haut." Freiburg : Universität, 2012. http://d-nb.info/1123474478/34.

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4

Feldmann, Friederike. "Implication of extraintestinal pathogenic Escherichia coli siderophore receptors in host pathogen interaction." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/649951/649951.pdf.

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5

Vyas, Ishan. "IDENTIFICATION OF PEPTIDASES IN HIGHLY-PATHOGENIC VERSUS WEAKLY-PATHOGENIC NAEGLERIA FOWLERI AMEBAE." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3524.

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Naegleria fowleri, a free-living ameba, is the causative agent of Primary Amebic Meningoencephalitis. Highly-pathogenic mouse-passaged amebae (Mp) and weakly-pathogenic axenically-grown (Ax) N. fowleri were examined for peptidase activity. Zymography and azocasein peptidase activity assays demonstrated that Mp and Ax N. fowleri exhibited a similar peptidase pattern. Prominent for whole cell lysates, membranes and conditioned medium from Mp and Ax amebae were the presence of an activity band of approximately 58kDa and 100 kDa bands susceptible to the action of cysteine and metallopeptidase inhi

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6

Ringsted, S. "Pathogenic mechanisms in glomerulonephritis." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670361.

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7

Salamina, M. "Helicobacter pylori Pathogenic Factors." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423803.

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From 1994, Helicobacter pylori was classified by WHO (World Health Organization) as a class I carcinogen and its infection has been associated to gastroduodenal disease. It colonizes more than half of worldwide population, with a prevalent infection rate in developed countries. In spite of the majority of infected people are asymptomatic, around 20% develop severe pathologies like peptic ulcers and the 1% lymphoma of the mucosa-associated lymphoid tissue (MALT) and stomach cancer. This significant epidemiological study both of the unique characteristics of H. pylori inspired many scientists, a

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8

Sousa, Oliveira Márcia Patrícia de. "Microbial safety of lettuce: foodborne pathogens incidence, their pathogenic potential and biopreservative stratagies." Doctoral thesis, Universitat de Lleida, 2015. http://hdl.handle.net/10803/307379.

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La investigació descrita en aquesta tesi es centra en la determinació de la influència de les pràctiques de maneig del cultiu, processament i les condicions d'emmagatzematge en la qualitat microbiològica de l'enciam mínimament processat i en l'estudi de les estratègies de mitigació per millorar la seva seguretat. S'ha estudiat l'efecte del sistema de producció, orgànica o convencional, de la qualitat microbiològica d'enciam fresc. Es va avaluar la transferència i la persistència de L. innocua i E. coli O157:H7 en els fulls d'enciam i en el sòl durant la tardor i la primavera utilitzant diferen

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9

Botelho, Rebecca A. "Plasmacytoid dendritic cell function in pathogenic vs. non-pathogenic HIV and SIV infection." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378484.

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10

Clayton, Selina Ruth. "The ZUR (zinc uptake regulator) regulon of pathogenic and non-pathogenic Escheria coli." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606007.

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The Zur (zinc uptake regulator) regulon of a range of pathogenic and non-pathogenic E. coli strains was explored by combining in silico Zur binding site predictions with experimental approaches. Initially, novel Zur-binding sites were predicted in the genomes of K-12 MG1655, 0157:H7 str. Sakai, H10407 and CFT073 using patser. The effect of both zinc depletion and zur deletion was probed in each strain by transcriptomics analysis, in order to identify direct Zur targets. Known Zur targets, including zinT, an auxiliary component of the znuABC zinc uptake system, and ykgM, an alternative non-zinc

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11

Turner, Paul Christopher. "Haem utilisation by pathogenic neisseriae." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326660.

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12

Dodd, Roger Bradley. "Structural studies of pathogenic proteins." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615193.

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13

Al-Mossawi, Mohammad Hussein. "Pathogenic immune responses in spondyloarthritis." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:eab12909-6af6-4269-85de-69fa99d11af7.

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Immune dysfunction in spondyloarthritis (SpA) causes significant morbidity to a large number of patients. An understanding of the underlying pathological processes involved in causing the disease is essential for the development and better targeting of therapies. I have shown for the first time in patients with SpA an overall expansion of peripheral blood and synovial fluid T cells producing GM-CSF and an expansion of GM-CSF positive Th17 cells. In addition, I have shown GM-CSF to be a major effector cytokine of joint-derived innate lymphoid cells. Surface phenotyping and transcriptional analy

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14

Bryant, Josephine Maria. "Evolutionary genomics of pathogenic mycobacteria." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708462.

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15

Cotter, Sheena C. "Trade-offs in insect disease resistance." Thesis, University of Stirling, 2002. http://hdl.handle.net/1893/26688.

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The ability to mount an efficient immune response should be an important life-history trait as parasitism can impact upon an individual's fecundity and survival prospects, and hence its fitness. However, immune function is likely to be costly as resources must be divided between many important traits. Whilst many studies have examined host resistance to particular parasite types, fewer have considered general immune responses. Studies that have considered general immune responses tend to do so in vertebrate models. However, the complexity of the vertebrate immune system makes the examination o

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16

VieBrock, Lauren. "ORIENTIA TSUTSUGAMUSHI ANKYRIN-REPEAT PROTEIN FAMILY TARGETING OF THE HOST ENDOPLASMIC RETICULUM." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4023.

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Abstract ORIENTIA TSUTSUGAMUSHI ANKYRIN REPEAT-PROTEIN FAMILY TARGETING OF THE HOST ENDOPLASMIC RETICULUM By Lauren VieBrock, B.S. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2015 Director: Jason A. Carlyon, Ph.D. Professor Microbiology and Immunology Scrub typhus is an understudied, potentially fatal febrile illness, which poses threat to one billion people annually in the Asia-Pacific region. The host-pathogen interactions that facilitate the intracellular surv

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17

Torriani, Stefano F. F. Torriani Stefano F. F. "Mitochondrial genomes of plant pathogenic fungi /." [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000265868.

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18

Clarke, Daniel William. "The pathogenic cascade of Acanthamoeba Keratitis." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=153.

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19

Corran, Andrew John. "Squalene synthase in plant pathogenic fungi." Thesis, Royal Holloway, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243317.

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20

Pettigrew, D. "Pathogenic ligands of decay-accelerating factor." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433336.

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21

Valanne, M. S. "The pathogenic potential of Propionibacterium acnes." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273147.

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22

Skinner, Wendy. "Non-pathogenic mutants of Mycosphaerella graminicola." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391093.

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23

Khan, Naveed Ahmed. "Detection and differentiation of pathogenic Acanthamoeba." Thesis, University of Hull, 1999. http://hydra.hull.ac.uk/resources/hull:12458.

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Acanthamoeba are free-living and opportunistic protozoa that are ubiquitous in nature. Human infection due to Acanthamoeba can involve the brain, skin, lung and eyes. However, eye infection, Acanthamoeba keratitis, is the most common infection. Acanthamoeba keratitis is a sight threatening corneal disease producing a progressive, blinding infection of the corneal surface. Several species of Acanthamoeba have been identified as human pathogens, however, current laboratory techniques for identification and speciation of Acanthamoeba are time consuming and laborious. The purpose of this study was

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24

Lau, Siu Ha. "Molecular epidemiology of pathogenic escherichia coli." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517731.

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25

Li, Qiuye. "Structural Studies of Pathogenic Protein Aggregates." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586199043739315.

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26

Segelmark, Mårten. "Pathogenic aspects of rapidly progressive glomerulonephritis." Lund : Dept. of Nephrology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39160027.html.

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27

Massey, Ward L. K. "Pathogenic mechanisms in human carious pulpitis." Thesis, The University of Sydney, 1992. http://hdl.handle.net/2123/4650.

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Doctor of Philosophy<br>This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

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28

Massey, Ward L. K. "Pathogenic mechanisms in human carious pulpitis." University of Sydney, 1992. http://hdl.handle.net/2123/4650.

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Doctor of Philosophy<br>This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

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29

Forster, Anthony Carlyle. "Self-cleavage of plant pathogenic RNAs." Title page, contents and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phf7331.pdf.

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30

Maresca, Alessandra <1982&gt. "Pathogenic mechanisms in mitochondrial optic neuropathies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3592/1/Maresca_Alessandra_tesi.pdf.

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Leber’s hereditary optic neuropathy (LHON) and Autosomal Dominant Optic Atrophy (ADOA) are the two most common inherited optic neuropathies and both are the result of mitochondrial dysfunctions. Despite the primary mutations causing these disorders are different, being an mtDNA mutation in subunits of complex I in LHON and defects in the nuclear gene encoding the mitochondrial protein OPA1 in ADOA, both pathologies share some peculiar features, such a variable penetrance and tissue-specificity of the pathological processes. Probably, one of the most interesting and unclear aspect of LHON is t

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31

Maresca, Alessandra <1982&gt. "Pathogenic mechanisms in mitochondrial optic neuropathies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3592/.

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Leber’s hereditary optic neuropathy (LHON) and Autosomal Dominant Optic Atrophy (ADOA) are the two most common inherited optic neuropathies and both are the result of mitochondrial dysfunctions. Despite the primary mutations causing these disorders are different, being an mtDNA mutation in subunits of complex I in LHON and defects in the nuclear gene encoding the mitochondrial protein OPA1 in ADOA, both pathologies share some peculiar features, such a variable penetrance and tissue-specificity of the pathological processes. Probably, one of the most interesting and unclear aspect of LHON is t

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32

Crossley, Brian E. "Role of the Exopolysaccharide Alginate in Adherence to and Inflammation of Pulmonary Epithelial Cells." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4473.

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Pseudomonas aeruginosa (PA) infections in Cystic Fibrosis (CF) patients are not easily cleared due to the conversion from a nonmucoid to a mucoid phenotype. Alginate is an acetylated exopolysaccharide produced by mucoid PA that is responsible for increased resistance to antibiotics, host phagocytic killing, and propagating biofilm formation. Understanding the interaction between PA and host cells is critical to understanding chronic infection and inflammation in CF. In order to investigate this, we used A549 pulmonary epithelial cells and murine alveolar macrophages (MH-S) to examine host resp

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33

Mohanty, Subhasis. "Role of pathogenic antibodies in rheumatic diseases." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967642760.

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34

Neelakanta, Girish. "Genome variations in commensal and pathogenic E.coli." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974330329.

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35

Sahlin, Charlotte. "Pathogenic Mechanisms of the Arctic Alzheimer Mutation." Doctoral thesis, Uppsala University, Department of Public Health and Caring Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7582.

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<p>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, neuropathologically characterized by neurofibrillay tangles and deposition of amyloid-β (Aβ) peptides. Several mutations in the gene for amyloid precursor protein (APP) cause familial AD and affect APP processing leading to increased levels of Aβ42. However, the Arctic Alzheimer mutation (APP E693G) reduces Aβ levels. Instead, the increased tendency of Arctic Aβ peptides to form Aβ protofibrils is thought to contribute to the pathogenesis. </p><p>In this thesis, the pathogenic mechanisms of the Arctic mutation were furthe

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36

Okanga, Francis Inyangala. "Biotransformation of cruciferous phytoalexins by pathogenic fungi." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0016/NQ37905.pdf.

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37

Smith, Hayden. "SOCIAL PATHOGENIC SOURCES OF POOR COMMUNITY HEALTH." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3496.

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The United States currently provides a health care system that is neither efficient nor equitable. Despite outspending the world on health care, over three-fourths of developed countries produce better health outcomes (Auerbach et al., 2000). Simultaneously, the "Ecological School of Thought" has documented the large impact that social, economic, and environmental circumstances play in health outcomes. Unfortunately, these 'ecological" studies are frequently conducted without theoretical justification, and rely solely on a cross-sectional research design and a myriad of unrelated variables. Th

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38

Kearney, Theresa Elizabeth. "Survival of pathogenic bacteria in anaerobic digesters." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334706.

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39

Ajaj, Fateh Omar. "Mineral transformations iin vitro by pathogenic fungi." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419564.

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40

Joseph-Horne, Tim. "Mechanisms of antifungal resistance in pathogenic fungi." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387760.

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41

Middleton, J. "Potentially pathogenic Phytophthora isolates in irrigation systems." Thesis, University of Reading, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354090.

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42

Kim, Hyung Joo. "Electrochemical detection and enumeration of pathogenic bacteria." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244045.

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43

Morris, B. M. "The electrotactic responses of plant pathogenic fungi." Thesis, University of Aberdeen, 1993. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU539652.

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Plant roots generate electrical fields in the rhizosphere as a consequence of their ion transport activities. In this thesis it is shown that zoospores of Phytophthora palmivora and Pythium aphanidermatum exhibit electrotaxis in electrical fields ≤ 50 mV/cm, comparable in size to the physiological fields around plant roots. P.palmivora zoospores showed anodotaxis and P.aphanidermatum zoospores cathodotaxis. An experimental protocol for applying weak electrical fields is described. In this sytem zoospores suspensions are isolated from the electrodes and their products using agarose bridges.

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44

Perera, Thanuja Harshini. "Regulation of thigmotropism in human pathogenic fungi." Thesis, University of Aberdeen, 1998. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU098400.

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Microscopical examination of <I>Candida albicans</I> grown on contoured artificial surfaces provided evidence that hyphae responded thigmotropically to features of the growth substrate. Hyphae of <I>C. albicans</I> followed grooves and ridges on various artificial membranes and penetrated pores of Nucleopore filters. The thigmotropic response in <I>C. albicans</I> was attenuated by gadolinium ions and by verapamil suggesting that calcium uptake may be involved in thigmotropic regulation. Thigmotropism was also observed for the first time in three genera of dermatophytic fungi <I>(Epidermophyto

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45

Collins, Cathleen A. "Ubiquitin in host defense against pathogenic mycobacteria." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3359543.

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46

Birk, Julia. "Fibrillar aggregations of pathogenic pro-vasopressin mutants /." Basel : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8880.

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47

Salmon, Richard Michael. "Structural studies on proteins from pathogenic bacteria." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3287/.

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48

Rawkins, Ann. "Virulence and pathogenic mechanisms of Legionella pneumophila." Thesis, Open University, 1994. http://oro.open.ac.uk/54371/.

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Strains of Legionella pneumophila which were virulent for guinea pigs were passaged on laboratory media such that they became avirulent. Virulent/avirulent pairs of strains were compared in an attempt to identify potential virulence or pathogenic factors. Virulent forms multiplied within guinea pig alveolar macrophages maintained in tissue culture over 48 hours and phagosome lysosome fusion was not inhibited in these macrophages. Avirulent strains did not multiply but those produced by passage on supplemented Mueller Hinton agar (MHIH) maintained viability whereas those produced by passage on

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49

Mpongoshe, Vuyiseka. "Gene expression changes in macrophages infected with pathogenic M. tuberculosis and non-pathogenic M. smegmatis and M. bovis BCG." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86729.

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Thesis (MScMedSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: The current anti-TB drugs have had success in decreasing the number of deaths caused by TB, however, this success is limited by the emergence of drug resistant TB strains. Therefore, a novel TB therapy that limits the development of resistance has become necessary in an attempt to effectively control TB. The anti-TB drugs directly target mycobacterial enzymes, and potentiate the development of this resistance, and have therefore provided the rationale for this study. The aim was therefore to identify host macrophage genes t

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50

Brownell, Abigael C. "The Roles of Microcystin and Sulfide in Physiology and Tactic Responses of Pathogenic and Non-Pathogenic Mat-Forming Cyanobacteria." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1364.

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Planktothricoides raciborskii and Roseofilum reptotaenium are physiologically similar, yet ecologically distinct organisms found in a hot spring outflow and coral black band disease (BBD), respectively. The aim of this study was to elucidate the relationship between R. reptotaenium and sulfide in BBD, to compare microcystin (MC) production in response to environmental factors, and to determine chemotactic responses to MC and sulfide by the two organisms. Results showed that the pathogenicity of R. reptotaenium in BBD is dependent on sulfate-reducing bacteria as secondary pathogens. Roseofilum

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