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Дисертації з теми "Patients recruitment"

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

Yan, Shiu-man Yolanda. "Patient recruitment strategies in clinical trials." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B24872623.

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2

殷小曼 and Shiu-man Yolanda Yan. "Patient recruitment strategies in clinical trials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970874.

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3

Sapey, Elizabeth. "Inflammation and neutrophil recruitment in ageing subjects and patients with chronic obstructive pulmonary disease." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1211/.

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Анотація:

The neutrophil is central to the development of COPD. To enter lung, neutrophils must migrate accurately from the circulation to inflamed tissue. It is unclear which migratory stimuli are important and whether COPD neutrophils vary in their migratory behaviour, either to controls or patients with similar lung disease. COPD sputum and plasma samples were collected on 11 occasions over one month. Significant correlations were demonstrated between the inflammatory biomarkers and between inflammatory biomarkers and markers of disease. IL-8 correlated most strongly both with other inflammatory medi

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4

Morandi, Tiffany. "Safety and efficacy of lung recruitment maneuvers in post-‐operative pediatric cardiac surgical patients." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/281775.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>OBJECTIVE: To demonstrate the safety of lung recruitment maneuvers in post-operative pediatric cardiac surgical patients. To assess the ability of lung recruitment maneuvers to improve lung function. HYPOTHESIS: We hypothesize that ventilator recruitment strategies be well-tolerated in cardiac patients, and that they may benefit such patients by improving physiologic variables such as lung function and oxygenation. METHODS: Sixty‐two

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5

Reinius, Henrik. "Open lung concept in high risk anaesthesia : Optimizing mechanical ventilation in morbidly obese patients and during one lung ventilation with capnothorax." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268498.

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Formation of atelectasis, defined as reversible collapse of aerated lung, often occurs after induction of anaesthesia with mechanical ventilation. As a consequence, there is a risk for hypoxemia, altered hemodynamics and impaired respiratory system mechanics. In certain situations, the risk for atelectasis formation is increased and its consequences may also be more difficult to manage. Anesthesia for bariatric surgery in morbidly obese patients and surgery requiring one-lung ventilation (OLV) with capnothorax are examples of such situations. In Paper I (30 patients with BMI > 40 kg/m2 sche

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6

Fletcher, Kate Elizabeth. "An investigation of practice and practitioner factors that influence the recruitment of patients to primary care based randomised controlled trials : case study of the Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) study." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3519/.

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Background: Patient recruitment to trials is problematic; many fail to achieve targets, leaving them underpowered and unable to address their hypothesis. Few solutions have been identified in existing literature. This thesis aimed to: identify factors associated with recruitment; and understand clinicians’ experiences of recruiting patients to a primary care based randomised controlled trial (RCT). This was explored using The Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) trial as a case study. Methods: Mixed methods were used: a systematic review to identify factors influencing

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7

Kulikov, Yuri. "Patient recruitment in a challenging surgical trial : issues and possible solutions." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/66691/.

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Randomised Controlled Trials (RCTs) are regarded as a ‘gold standard’ technique to evaluate and compare clinical interventions. Strict ethical criteria dictate the participation of humans in clinical research, based on informed consent, voluntary decision making and putting patients’ interests first. Demand for RCTs in Trauma and Orthopaedics is high, but patient recruitment continues to pose a significant challenge, especially when the treatments being compared are obviously different. Lack of blinding, treatment preference and negative perception of random allocation to interventions are amo

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8

Heikari, J. M. (Juho-Matti). "The use of social media in patient recruitment for clinical trials in medical device start-up from the perspective of social media agencies and patient recruitment firms:case Synoste." Master's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201711293189.

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The aim of this research is to provide novel approach how to use social media in patient recruitment for clinical trials. This research has been commissioned by a Finland based company Synoste, and is limited to consider the patient recruitment in a medical device start-up with a very limited number of patients. To be able to produce new approach into existing literature, this study has been conducted as a qualitative case study from the perspective of social media agencies and patient recruitment firms. Understanding the factors, such as scarce information about the clinical trials, possible

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9

Hutchison, Catherine B. "A randomised controlled trial of an audiovisual patient information intervention in cancer clinical trials." Thesis, University of Stirling, 2008. http://hdl.handle.net/1893/442.

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Introduction and background Recruitment to cancer clinical trials needs to be improved, as does patient understanding about clinical trials, to enable patients to make an informed choice about whether or not to take part. The main reason that clinically eligible patients do not take part in clinical trials is because they refuse; poor understanding of the research has been associated with patient refusal. Audiovisual patient information (AVPI) has been shown to improve knowledge/understanding in various areas of practice but there is limited information about its effect in the cancer clinical

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10

Fritzsche, Katrin. "Der Sauerstoffverbrauch der Lunge (VO2pulm) bei Patienten mit Acute Lung Injury (ALI) und Acute Respiratory Distress Syndrome (ARDS) unter mechanischer Beatmung und PEEP-Variation, gemessen als VO2-Differenz zwischen indirekter Kalorimetrie und Berechnung über das inverse Fick´ sche Prinzip." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1196375360464-83262.

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Bei Patienten mit einem akuten Lungenversagen (ALI oder ARDS) ist der Sauerstoffverbrauch der Lunge (VO2pulm) durch pathophysiologische Prozesse insbesondere die Ausbildung von Atelektasen stark beeinträchtigt. Aufgrund der Annahme, dass eine Steigerung der Anzahl ventilierter Lungenareale zu einer Erhöhung des pulmonalen Sauerstoffverbrauchs führt, haben wir den Einfluss eines definierten Rekrutierungsmanövers (PEEP/PEAK + 10 cmH2O) auf den pulmonalen Sauerstoffverbrauch (VO2pulm), pulmonalen kapillären Blutfluss (PCBF), der den nicht geshunteten Anteil am HZV darstellt, und den transpulmonal

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11

Detoc, Maëlle. "Déterminants à la participation ou non à un essai vaccinal préventif." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSES016.

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Анотація:

La mise au point de nouveaux vaccins reste cruciale, notamment dans le contexte des épidémies dues à des pathogènes émergents et de la lutte contre l’antibiorésistance. Le développement clinique des vaccins prend du temps et coûte cher. Optimiser le recrutement dans ces essais est donc primordial. L’objectif a donc été d’identifier les barrières et motivations à la participation à un essai vaccinal. L’altruisme et l’indemnisation financière ont ainsi été identifiés dans notre revue de la littérature comme facteurs motivants principaux et la peur des effets secondaires et le design de l’étude c

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12

Hughes-Morley, Adwoa. "What are effective methods to recruit research participants into mental health trials?" Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/what-are-effective-methods-to-recruit-research-participants-into-mental-health-trials(00c200de-b35f-4389-b9a4-afdfb9205453).html.

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Background: There is a great need for effective treatments for mental health problems. Randomised controlled trials are the gold standard for evaluating treatments, however recruitment into trials is challenging, highlighting a clear need for evidence-based recruitment strategies. This thesis aimed to systematically develop a recruitment intervention and evaluate its effectiveness for improving the recruitment of participants into mental health trials. Methods: A mixed-methods approach, adopting the Medical Research Council’s complex interventions framework: 1) a systematic review to identify

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13

Edwards, Zoe, M. I. Bennett, Duncan R. Petty, and Alison Blenkinsopp. "Evaluating recruitment methods of patients with advanced cancer: a pragmatic opportunistic comparison." 2019. http://hdl.handle.net/10454/17146.

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Yes<br>Background: Recruitment of patients with advanced cancer into studies is challenging. Objective: To evaluate recruitment methods in a study of pharmacist-led cancer pain medicines consultations and produce recommendations for future studies. Method: Two methods of recruitment were employed: 1) community-based (general practitioner computer search, identification by general practitioner, community pharmacist or district nurse and hospital outpatient list search), and 2) hospice-based (in and outpatient list search). Patients identified in method 1 were invited by post and in method 2 w

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14

Ya-i, Hsieh, and 謝雅宜. "Clinical Efficacy of Manual Hyperinflation on Alveolar Recruitment in Difficult Weaning Patients." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/01694989282061929660.

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碩士<br>長庚大學<br>護理學研究所<br>90<br>Use of mechanical ventilator support through tracheostomy or intubation has been one of extremely important medical intervention to help support life for ICU patients. However, as the result of using current medical intervention for patients with lung collapse during mechanical ventilation is limited, manual hyperinflation helps alveolar recruitment that results in secretion clearance, ventilation improvement, lung collapse prevention, lung collapse re-inflation, dynamic compliance improvement, artery oxygenation improvement and work of breathing reduction accordi

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15

Wu, Vivian. "Recruitment, single ventricular palliation, and complex biventricular repair for patients with Hypoplastic Left Heart Syndrome." Thesis, 2019. https://hdl.handle.net/2144/36723.

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BACKGROUND: Hypoplastic Left Heart Syndrome is a congenital birth defect that is defined by underdevelopment of the left heart during pregnancy. This is especially dangerous as the left heart holds the systemic flow of blood- the oxygenated blood. Not enough oxygen throughout the whole body causes cyanosis, which symptoms include bluish discoloration of the skin or mucous membrane due to low oxygen saturation. Single Ventricle Palliation followed by Biventricular Conversion is the most common surgical procedural pathway to correct this defect. The goal is to convert from a single ventricle cir

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16

Liu, YiHsien, and 劉乙諴. "Recruitment of Masticatory Muscles and Sternocleidomastoid Muscle at Different Retrusive-Protrusive Jaw Position in Patients of TMJ Arthritis." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/43727379716274540301.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>88<br>The purpose of this study was to examine the recruitment of masticatory muscles and sternocleidomastoid muscle at different protrusive-retrusive jaw positions under the control of biting forces. Twenty female patients of TMJ arthritis whose overjet and overbite of anterior teeth had found to be changed during the course of treatment were included in this study. Twenty-one normal subjects with similar age, height and weight were selected as control group. A fork-type force transducer was constructed with four bonded strain gauges connected in full b

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17

Stellos, Konstantinos L. [Verfasser]. "Platelet-derived SDF-1 regulates recruitment, proliferation and differentiation of human CD34+ progenitor cells : implications in patients with acute myocardial infarction / vorgelegt von Konstantinos L. Stellos." 2007. http://d-nb.info/985139722/34.

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18

RINALDO, Nicoletta. "Models of Physical Activity: Active Lifestyle Promotion for adults and elderly people affected by Chronic Obstruction Pulmonary Disease." Doctoral thesis, 2013. http://hdl.handle.net/11562/567349.

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Background e obiettivi L’intolleranza all’esercizio fisico (ES), la sintomatologia e gli effetti extra-polmonari incrementano il rischio di disabilità, bassa qualità della vita (QoL) e sedentarietà nel paziente affetto da Broncopneumopatia Cronica Ostruttiva (BPCO). In riabilitazione respiratoria l’ES è considerato il principale intervento non farmacologico per incrementare la salute e la capacità di esercizio nei pazienti. Sfortunatamente, si rilevano pochi interventi strutturati di attività fisica (AF). Inoltre, un numero elevato di pazienti declina la partecipazione. Le ragioni di abbandon

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19

"Aspects of patient recruitment in clinical trials with continuous outcomes: A simulation study." Tulane University, 1990.

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Анотація:

Recent attention has focused on the performance of sample selection techniques employed in clinical research. In studies having a specified, yet arbitrary, target population, one objective of recruiting is to limit enrollment to members of this group. However, when eligibility is determined by observations of a continuous response variable, ineligible patients may be enrolled due to the misclassification resulting from truncated sampling. It is believed that these screening failures will have a negative impact on a study although the severity of the effect is unknown. This study examined the p

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20

McGovern, Kathleen. "The challenge of 5,250: a retrospective analysis of participant recruitment methods utilized by the epilepsy phenome/genome project." Thesis, 2014. https://hdl.handle.net/2144/14371.

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Epilepsy is a common neurological disorder, with potentially devastating consequences, and thus, elucidating the etiology bears immense potential for developing methods for early detection and prevention, targeted treatment options, and overall improvements to quality of life for millions of people worldwide. In 2007, the Epilepsy Phenome/Genome Project (EPGP) set out to compile the largest ever, detailed phenotype-genotype dataset to begin to unravel the complex genetic underpinnings of epilepsy. Over the course of five years, the EPGP sought to enroll a total of 5,250 participants consisting

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21

Knapp, P., S. Gilbody, J. Holt, et al. "Optimised patient information materials and recruitment to a study of behavioural activation in older adults: an embedded study within a trial." 2020. http://hdl.handle.net/10454/18022.

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Yes<br>Printed participant information about randomised controlled trials is often long, technical and difficult to navigate. Improving information materials is possible through optimisation and user-testing, and may impact on participant understanding and rates of recruitment. Methods: A study within a trial (SWAT) was undertaken within the CASPER trial. Potential CASPER participants were randomised to receive either the standard trial information or revised information that had been optimised through information design and user testing. Results: A total of 11,531 patients were randomised in

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22

Chung, Shu-Yu. "The multidimensional kidney transplant self-management scale : development and psychometric testing." Diss., 2018. https://doi.org/10.7912/C24M2N.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Poor long-term kidney transplant outcomes are a significant problem in the U.S. Interventions must focus on preserving allograft function by managing modifiable risk factors. An instrument capable of identifying problems with post-kidney transplant self-management behaviors may enable the design and testing of self-management interventions. This study’s purpose was to test the psychometric properties of the new Kidney Transplant Self-Management Scale (KT–SM). The Zimmerman framework adapted for kidney transplant self-management

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23

Covell, Christine Lynn. "The Relationship of Nursing Intellectual Capital to the Quality of Patient Care and the Recruitment and Retention of Registered Nurses." Thesis, 2011. http://hdl.handle.net/1807/29692.

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To ensure quality patient care hospitals invest in nursing intellectual capital by allocating financial, human and material resources for nurses to acquire the knowledge and skills necessary to provide safe patient care. This study’s purpose was to test selected propositions of the middle-range theory of nursing intellectual capital which provides a conceptualization of the influence of nurses’ knowledge, skills and experience (nursing human capital) to patient and organizational outcomes. The theory was systematically developed after a critical review of the literature. It proposes that nursi

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24

Raynor, Pauline, and Born in Bradford Collaborative Group. "Born in Bradford, a cohort study of babies born in Bradford, and their parents: protocol for the recruitment phase." 2008. http://hdl.handle.net/10454/7000.

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BACKGROUND: Bradford, one of the most deprived cities in the United Kingdom, has a wide range of public health problems associated with socioeconomic deprivation, including an infant mortality rate almost double that for England and Wales. Infant mortality is highest for babies of Pakistani origin, who comprise almost half the babies born in Bradford. The Born in Bradford cohort study aims to examine environmental, psychological and genetic factors that impact on health and development perinatally, during childhood and subsequent adult life, and those that influence their parents' health and w

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25

Brandão, Inês Cardoso. "Fatores Diferenciadores de Centros de Ensaios Clínicos em Portugal." Master's thesis, 2021. http://hdl.handle.net/10316/99012.

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Dissertação de Mestrado em Farmacologia Aplicada apresentada à Faculdade de Farmácia<br>A investigação clínica representa uma atividade de valor no desenvolvimento de novos medicamentos, encontrando-se em exponencial evolução em Portugal. Esta apresenta benefícios sociais e económicos importantes e possibilita o acesso precoce, por parte dos doentes, a moléculas inovadoras, contribuindo igualmente para uma melhoria da prestação de cuidados de saúde e favorecendo a esperança e qualidade de vida da população portuguesa.Os ensaios clínicos possuem grande relevância, promovendo o desenvolvimento n

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