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Статті в журналах з теми "Phenylephrine Hcl"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Patel, Satish A., and Dharmendrasinh A. Baria. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF NAPHAZOLINE HCL AND PHENYLEPHRINE HCL IN EYE DROPS." INDIAN DRUGS 57, no. 06 (2020): 26–31. http://dx.doi.org/10.53879/id.57.06.11613.

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Анотація:

A first order derivative UV-spectrophotometric method was developed to quantify naphazoline hydrochloride and phenylephrine hydrochloride in eye drops. Naphazoline hydrochloride and phenylephrine hydrochloride were estimated at 275.6nm (zero crossover point of phenylephrine hydrochloride) and 289.4nm (zero crossover point of naphazoline hydrochloride), respectively. The method was found to be linear in the concentration range of 10 - 25 µg/ml for naphazoline hydrochloride and 20 - 60 µg/ml for phenylephrine hydrochloride. The developed method was subjected to validation in accordance with ICH

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2

Patel, Mehul, Bhavna Patel, and Shraddha Parmar. "Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method." Journal of Spectroscopy 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/364750.

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A simple, precise, rapid, and economic method was developed for the simultaneous determination of Ibuprofen and Phenylephrine HCl in bulk and combined dosage form. This method involves first-order derivative spectroscopy using 248 nm and 237 nm as zero crossing points for Ibuprofen and Phenylephrine HCl, respectively. For spectrophotometric method 0.1 N NaOH was used as a solvent. The linearity was established over the concentration range of 12–72 μg/mL and 1.5–22 μg/mL for Ibuprofen and Phenylephrine HCl with correlation coefficient (r2) of 0.9972 and 0.9981, respectively. The mean % recoveri

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3

H. Hasan, Shlear, Nabeel S. Othman, and Kafia M. Surchi. "Determination of Phenylephrine-HCl Using Conductometric Titration Method." Current Analytical Chemistry 12, no. 4 (2016): 330–34. http://dx.doi.org/10.2174/1573412912666151126205443.

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4

Dagariya, Rishabh Kumar, Mehul B. Barad, and U. A. Kalele. "STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF DEXTROMETHORPHAN HBr, PHENYLEPHRINE HCl AND CHLORPHENIRAMINE MALEATE IN THEIR COMBINED SYRUP DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY." Tropical Journal of Pharmaceutical and Life Sciences 8, no. 3 (2021): 01–16. https://doi.org/10.61280/tjpls.v8i3.68.

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Анотація:

The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Dextromethorphan HBr, Phenylephrine HCl and Chlorpheniramine Maleate in syrup dosage form. The quantification was carried out using Phenomenex Luna 5µm C8(2)100Å;250×4.6mm (Part No.00G-4249-E0) column and mobile phase comprised of Buffer pH 3.2 and Acetonitrile with gradient elution mode. The flow rate was 1.0 ml/min and the eluent was monitored at 220 nm. The selected chromatographic conditions were found to effectively separate Dextromethorphan HBr, Phenylephrine

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5

Nagarjuna, PJ, B. Tharun Kumar, and Buchi N. Nalluri. "Simultaneous Analysis of Phenylephrine HCl and Ketorolac Tromethamine in Bulk and Injectable Formulations by RP-HPLC-PDA Method." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 39–45. http://dx.doi.org/10.22270/jddt.v10i4-s.4204.

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Rapid, isocratic and economical RP-HPLC-PDA method was developed for the simultaneous estimation of Phenylephrine HCl (PEH) and Ketorolac Tromethamine (KTR) in bulk and injectable dosage forms. Chromatographic separation was achieved with the Agilent Eclipse C18 column (150×4.6mm;5µ) and the mobile phase composed of methanol and 2mM Ammonium acetate in the ratio 43:57v/v at a flow rate of 1mL/min. The injection volume was 5µL and eluents were monitored at 220nm. Response was a linear function of concentration in the range 30–105 μg/mL for Phenylephrine HCl (PEH) and 10–35 μg/mL Ketorolac Trome

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6

Kumar, S. Ashutosh, Manidipa Debnath, and D. Vimala. "Simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in a pharmaceutical (syrup) formulations by RP-HPLC using PDA detector." Pakistan Journal of Pharmaceutical Research 2, no. 2 (2016): 89. http://dx.doi.org/10.22200/pjpr.2016289-97.

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Анотація:

The present study aimed to develop and validate the simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in tablet dosage forms. A gradient reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 220 nm has been developed for the simulataneous determination of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in pharmaceutical dosage forms (Syrup). Good chromatographic separation was achieved by using a stainless steel analytical column, the Hypersil BDS C8 column (4.6 X 250 mm; 5 μm). The

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7

Harreveld, P. D., Judy Cox, and D. S. Biller. "Phenylephrine HCl as a treatment of nephrosplenic entrapment in a horse." Equine Veterinary Education 11, no. 6 (1999): 282–84. http://dx.doi.org/10.1111/j.2042-3292.1999.tb01554.x.

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8

Pirol, Ozan, Murat Sukuroglu, and Tuncel Ozden. "Simultaneous Determination of Paracetamol, Phenylephrine Hydrochloride, Oxolamine Citrate and Chlorpheniramine Maleate by HPLC in Pharmaceutical Dosage Forms." E-Journal of Chemistry 8, no. 3 (2011): 1275–79. http://dx.doi.org/10.1155/2011/454325.

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A new high performance liquid chromatographic (HPLC) method was developed for the determination of paracetamol, phenylephrine hydrochloride, oxolamine citrate and chlorpheniramine maleate in combined pharmaceutical formulations and dosage forms. The separation was performed on an Agilent Zorbax SB-CN column with the mobile phase consisting of 0.02 M phosphate buffer (pH:4) and acetonitrile (85:15,v/v) in flow rate 1.5 mL at 22 °C. The overall retention time of the analytes was 3.5 min. The method was validated with respect to linearity, precision, accuracy and recovery. The relative standard d

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9

Bonde, Minal, Anwar Daud, and Nidhi Sapkal. "Full factorial design, physicochemical characterization of phenylephrine HCl loaded oral thin film." Asian Journal of Pharmaceutics 9, no. 2 (2015): 137. http://dx.doi.org/10.4103/0973-8398.154718.

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10

Sridevi, S., R. Vijayakumar, and C. N. Nalini. "Method Development and Validation for the Simultaneous Estimation of Ascorbic acid, Phenylephrine HCl, Paracetamol and Levocetirizine HCl using RP-HPLC." Research Journal of Pharmacy and Technology 13, no. 4 (2020): 1913. http://dx.doi.org/10.5958/0974-360x.2020.00344.3.

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11

Cui, Jian, Thad E. Wilson, and Craig G. Crandall. "Phenylephrine-induced elevations in arterial blood pressure are attenuated in heat-stressed humans." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283, no. 5 (2002): R1221—R1226. http://dx.doi.org/10.1152/ajpregu.00195.2002.

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To test the hypothesis that phenylephrine-induced elevations in blood pressure are attenuated in heat-stressed humans, blood pressure was elevated via steady-state infusion of three doses of phenylephrine HCl in 10 healthy subjects in both normothermic and heat stress conditions. Whole body heating significantly increased sublingual temperature by ∼0.5°C, muscle sympathetic nerve activity (MSNA), heart rate, and cardiac output and decreased total peripheral vascular resistance (TPR; all P < 0.005) but did not change mean arterial blood pressure (MAP; P > 0.05). At the highest dose of phe

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12

Shama, S. A. "Spectrophotometric determination of phenylephrine HCl and orphenadrine citrate in pure and in dosage forms." Journal of Pharmaceutical and Biomedical Analysis 30, no. 4 (2002): 1385–92. http://dx.doi.org/10.1016/s0731-7085(02)00437-5.

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13

Bachute, Madhusudan T., Sunil V. Shanbhag, and Shankar L. Turwale. "Simultaneous determination of four active pharmaceuticals in tablet dosage form by reversed-phase high performance liquid chromatography." Tropical Journal of Pharmaceutical Research 18, no. 10 (2021): 2161–66. http://dx.doi.org/10.4314/tjpr.v18i10.23.

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Анотація:

Purpose: To develop a single, low-cost and rapid analytical method for the simultaneous determination of four active components - chlorpheniramine maleate, paracetamol, phenylephrine hydrochloride and caffeine – in a tablet dosage form. Method: This method was based on reverse-phase high performance liquid chromatography (RPHPLC) and involved the use of a C-18 column (250 × 4.6 mm, 5.0 μm), a mobile phase consisting of buffer solution and methanol at a flow rate of 1.00 mL/min, and gradient determination with UV detection at 220 nm. Results: Retention time was 4.33, 10.36, 13.85, a

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14

HOGAN, TAMMY S., DANNA D. McDANIEL, JIMMY D. BARTLETT, KATHRYN K. HART, and DARIO A. PAGGIARINO. "Dose-Response Study of Dapiprazole HCl in the Reversal of Mydriasis Induced by 2.5% Phenylephrine." Journal of Ocular Pharmacology and Therapeutics 13, no. 4 (1997): 297–302. http://dx.doi.org/10.1089/jop.1997.13.297.

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15

Nowakowska, Danuta, J. Saczko, Julita Kulbacka, A. Choromanska, and Z. Raszewski. "Cytotoxic Potential of Vasoconstrictor Experimental Gingival Retraction Agents in Vitro Study on Primary Human Gingival Fibroblasts." Folia Biologica 58, no. 1 (2012): 37–43. http://dx.doi.org/10.14712/fb2012058010037.

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Анотація:

The aim of this in vitro study was to evaluate the cytotoxic effects of the vasoconstrictor experimental gingival retraction agents (VEGRAs) in a dynamic setting. The strong cytotoxic effects of the astringent-based conventional gingival retraction agents (ACGRAs) on human gingival fibroblasts (HGFs) in vitro was our motivation to evaluate the biocompatibility of the vasoconstrictor-based experimental gingival retraction agents (VEGRAs) for the selected minimally invasive chemical agent. These agents were used to create three self-made retraction gels. Human gingival fibroblasts (HGFs) were tr

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16

Ellora, Ellora, Effendy De Lux Putra, and Ginda Haro. "Optimasi Fase Gerak Kromatografi Cair Kinerja Tinggi Pada Penetapan Kadar Parasetamol, Gliseril Guaiakolat, Klorfeniramin Maleat, dan Fenilefrin Hcl Dalam Sediaan Tablet Secara Simultan." Talenta Conference Series: Tropical Medicine (TM) 1, no. 1 (2018): 224–29. http://dx.doi.org/10.32734/tm.v1i1.80.

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Di pasaran, terdapat berbagai sediaan obat yang mengkombinasikan dua atau lebih zat aktif dalam satu sediaan, salah satunya adalah obat flu yang mengandung parasetamol, klorfeniramin maleat, gliseril guaiakolat dan fenilefrin hidroklorida. Penelitian ini bertujuan untuk menetapkan kadar keempat campuran zat aktif tersebut secara simultan karena analisis keempat campuran zat aktif tersebut belum ditemukan baik di Farmakope Indonesia maupun di United States Pharmacopoeia. Penelitian dilakukan dengan mengoptimasi berbagai jenis campuran fase gerak yaitu metanol dengan buffer fosfat pH 4,1; metano

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17

Anjali, Tandel Priya Shah Sadhana Rajput*. "SIMULTANEOUS ESTIMATION OF PHENYLEPHRINE HYDROCHLORIDE AND KETOROLAC TROMETHAMINE USING UV SPECTROPHOTOMETRIC AND HPLC METHODS." INDO AMERICAN OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7381–89. https://doi.org/10.5281/zenodo.1006802.

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This study involve development of a simple, sensitive, precise, accurate and economic HPLC method and two UV methods for simultaneous estimation of phenylephrine HCl (Phe) and ketorolac tromethamine (Ket). The UV methods are based upon absorption correction and multicomponent analysis approach. Wavelength maxima (λmax) selected for Phe and Ket were 273 nm and 323 nm respectively. Selected linearity ranges for Phe and Ket were 12-42 ppm and 4-14 ppm respectively for UV methods. HPLC method was developed using Waters HILIC (Hydrophilic interaction liquid chromatography) column having dimension o

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18

Senyuva, H., and T. Ozden. "Simultaneous High-Performance Liquid Chromatographic Determination of Paracetamol, Phenylephrine HCl, and Chlorpheniramine Maleate in Pharmaceutical Dosage Forms." Journal of Chromatographic Science 40, no. 2 (2002): 97–100. http://dx.doi.org/10.1093/chromsci/40.2.97.

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19

Meltzer, Eli O., Paul H. Ratner, and Thomas McGraw. "Oral Phenylephrine HCl for Nasal Congestion in Seasonal Allergic Rhinitis: A Randomized, Open-label, Placebo-controlled Study." Journal of Allergy and Clinical Immunology: In Practice 3, no. 5 (2015): 702–8. http://dx.doi.org/10.1016/j.jaip.2015.05.007.

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20

Zafirova, Marija, Jelena Acevska, Liljana Ugrinova, et al. "Development and optimization of a generic HPLC method for the simultaneous determination of common ingredients in multi component cough and cold oral drug products using chemometrics." Macedonian Pharmaceutical Bulletin 63, no. 02 (2018): 49–65. http://dx.doi.org/10.33320/maced.pharm.bull.2017.63.02.006.

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Анотація:

The aim of this work was to develop a single, generally applicable high performance liquid chromatography/diode array detector (HPLC/DAD) method for simultaneous determination of the most frequently used cough and cold active substances and their impurities that would be applicable for a number of possible formulation compositions of cough and cold medicines. The compounds that are separated by the method include eleven active substances: paracetamol, phenylephrine HCl, caffeine, ibuprofen, ascorbic acid, propiphenazone, pheniramine maleate, chlorphenamine maleate, pseudoephedrine HCl, dextrom

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21

Trivedi, Harshal K., and Mukesh C. Patel. "Development and Validation of a Precise and Stability Indicating LC Method for the Determination of Benzalkonium Chloride in Pharmaceutical Formulation Using an Experimental Design." E-Journal of Chemistry 7, no. 4 (2010): 1514–22. http://dx.doi.org/10.1155/2010/681420.

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A simple, precise, shorter runtime and stability indicating reverse-phase high performance liquid chromatographic method has been developed and validated for the quantification of benzalkonium chloride (BKC) preservative in pharmaceutical formulation of sparfloxacin eye drop. The method was successfully applied for determination of benzalkonium chloride in various ophthalmic formulations like latanoprost, timolol, dexametasone, gatifloxacin, norfloxacin, combination of moxifloxacin and dexamethasone, combination of nepthazoline HCl, zinc sulphate and chlorpheniramine maleate, combination of to

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22

Nyman, Neal, and Kenneth Daniels. "STUDY OF TWO DIFFERENT FORMULATIONS OF DAPIPRAZOLE HCL IN THE REVERSAL OF MYDRIASIS INDUCED BY 2.5% PHENYLEPHRINE AND 0.5% TROPICAMIDE." Optometry and Vision Science 72, SUPPLEMENT (1995): 143. http://dx.doi.org/10.1097/00006324-199512001-00237.

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23

Gelotte, Cathy K., and Brenda A. Zimmerman. "Pharmacokinetics, Safety, and Cardiovascular Tolerability of Phenylephrine HCl 10, 20, and 30 mg After a Single Oral Administration in Healthy Volunteers." Clinical Drug Investigation 35, no. 9 (2015): 547–58. http://dx.doi.org/10.1007/s40261-015-0311-9.

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24

Brenner, S., E. Hodak, D. Dascalu, R. Lurie, and R. Wolf. "A possible case of drug-induced familial pemphigus." Acta Dermato-Venereologica 70, no. 4 (1990): 357–58. http://dx.doi.org/10.2340/0001555570357358.

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Two sisters developed pemphigus vulgaris and pemphigus erythematosus within 3 years. The diagnosis was confirmed by clinical, histologic and immunofluorescent antibody studies. One of the sisters experienced a common cold before the pemphigus developed and displayed a positive macrophage migration inhibition (MIF) test to a combination drug compounded of paracetamol, caffeine, chlorpheniramine maleate and phenylephrine HCl, which she had received 2 weeks prior to the appearance of the cutaneous lesions. It is suggested that her pemphigus was triggered by the drug. Although the patient had a st

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25

Hellyer, Peter W., John R. Dodam, and Gwen S. Light. "Dynamic baroreflex sensitivity in anesthetized horses, maintained at 1.25 to 1.3 minimal alveolar concentration of halothane." American Journal of Veterinary Research 52, no. 10 (1991): 1672–75. http://dx.doi.org/10.2460/ajvr.1991.52.10.1672.

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SUMMARY Dynamic baroreflex sensitivity for increasing arterial pressure (dbsi) was used to quantitatively assess the effects of anesthesia on the heart rate/arterial pressure relationship during rapid (≤ 2 minutes) pressure changes in the horse. Anesthesia was induced with iv administration of xylazine and ketamine and maintained with halothane at a constant end-tidal concentration of 1.1 to 1.2% (1.25 to 1.3 minimal alveolar concentration). Systolic arterial pressure (sap) was increased a minimum of 30 mm of Hg in response to an iv bolus injection of phenylephrine HCl. Linear regression was u

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26

Otten, Cecilia, and Karen S. Dunn. "Case Report." Orthopaedic Nursing 43, no. 1 (2024): 41–44. http://dx.doi.org/10.1097/nor.0000000000001001.

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Priapism is a disorder where the penis without sexual stimulation maintains a prolonged rigid erection lasting 4 or more hours. There are two classifications of priapism, ischemic (low flow) or nonischemic high flow, and each have specific etiologies, diagnostic criteria, and management. This presented case study involved a 58-year-old male who experienced an ischemic priapism more than 24 hours after an anterior lumbar interbody fusion (ALIF). A flaccid penis was achieved after the patient received two 400 µg of phenylephrine HCL into the corpora cavernosum. Review of the literature suggests

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27

Rosireddy, Vineetha, and Manikandan Krishnan. "An ecologically sustainable RP-HPLC method for the trinary estimation of phenylephrine HCl, chlorpheniramine maleate, and dextromethorphan hydrobromide using AQbD and degradation studies." Analytical Chemistry Letters 14, no. 3 (2024): 406–25. http://dx.doi.org/10.1080/22297928.2024.2363894.

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28

Ibrahim, Huda A., Mahmood A. Hasan, Hadar M. Abdullah, and Mohammed Y. Khalaf. "Spectrophotometric determination of clotrimazole and Phenylephrine-HCl in pharmaceutical formulation using 1, 2-naphthoquinone-4-Sulphonic acid sodium salt (NQS) as a chromogenic reagent." Journal of the Indian Chemical Society 99, no. 3 (2022): 100373. http://dx.doi.org/10.1016/j.jics.2022.100373.

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29

Aljeboree, Aseel M., Shaimaa M. Essa, Farah A. Dawood, Mohammed S. Ali, and Ayad F. Alkaim. "Eco-friendly Analytical Method for Estimation for Benzodiazepine Drug in Pure and Pharmaceuticals Formulations by Oxidative Coupling Reaction with Phenylephrine Hydrochloride." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 01 (2023): 313–16. http://dx.doi.org/10.25258/ijddt.13.1.51.

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A simple, fast, sensitive and selective spectrophotometric method has been developed based on the oxidative coupling reaction process, which depends on the determination of clonazepam (CZP) drug using an oxidizing agent sodium periodate (NaIO4) in the presence of a reagent, phenylephrine hydrochloride (PH-HCL), that uses the pink color of CZP at a wavelength of 495 nm. Where several factors aff ecting the color intensity and absorbance were studied, including the eff ect of color stability time, eff ect of the volume of the reagent, the eff ect of the volume of the oxidizing agent, order of ad

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30

Bedford, T. G., and C. M. Tipton. "Exercise training and the arterial baroreflex." Journal of Applied Physiology 63, no. 5 (1987): 1926–32. http://dx.doi.org/10.1152/jappl.1987.63.5.1926.

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To test the hypothesis that endurance training would attenuate the carotid sinus baroreflex in rats, studies were undertaken with 25 nontrained (NT) and 22 trained (T) male Sprague-Dawley rats that were exercised for 11–14 wk. Maximal O2 consumption was significantly increased 10% after training. The left carotid sinus region was functionally isolated in anesthetized animals. Subsequently, static carotid sinus pressure was raised in 20-Torr increments from 95 Torr until a maximal response in systemic arterial pressure and regional blood flows was recorded. Compared with the NT group, barorefle

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31

Cui, Jian, Thad E. Wilson, and Craig G. Crandall. "Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 5 (2002): H1717—H1723. http://dx.doi.org/10.1152/ajpheart.00899.2001.

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Анотація:

The purpose of this project was to test the hypothesis that baroreceptor modulation of muscle sympathetic nerve activity (MSNA) and heart rate is altered during the cold pressor test. Ten subjects were exposed to a cold pressor test by immersing a hand in ice water for 3 min while arterial blood pressure, heart rate, and MSNA were recorded. During the second and third minute of the cold pressor test, blood pressure was lowered and then raised by intravenous bolus infusions of sodium nitroprusside and phenylephrine HCl, respectively. The slope of the relationship between MSNA and diastolic bloo

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32

Cui, Jian, Thad E. Wilson, Manabu Shibasaki, Nicole A. Hodges, and Craig G. Crandall. "Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans." Journal of Applied Physiology 91, no. 4 (2001): 1679–86. http://dx.doi.org/10.1152/jappl.2001.91.4.1679.

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To identify whether muscle metaboreceptor stimulation alters baroreflex control of muscle sympathetic nerve activity (MSNA), MSNA, beat-by-beat arterial blood pressure (Finapres), and electrocardiogram were recorded in 11 healthy subjects in the supine position. Subjects performed 2 min of isometric handgrip exercise at 40% of maximal voluntary contraction followed by 2.5 min of posthandgrip muscle ischemia. During muscle ischemia, blood pressure was lowered and then raised by intravenous bolus infusions of sodium nitroprusside and phenylephrine HCl, respectively. The slope of the relationship

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33

Okamoto, H., S. Hoka, T. Kawasaki, M. Sato, and J. Yoshitake. "Effects of CGRP on baroreflex control of heart rate and renal sympathetic nerve activity in rabbits." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 263, no. 4 (1992): R874—R879. http://dx.doi.org/10.1152/ajpregu.1992.263.4.r874.

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We examined the effects of intravenous infusion of calcitonin gene-related peptide (CGRP) and sodium nitroprusside (SNP) on baroreceptor afferent nerve activity, renal sympathetic efferent nerve activity (RSNA), and heart rate in alpha-chloralose-anesthetized rabbits. Baroreceptor afferent nerve activity was measured from aortic nerves during CGRP- and SNP-induced hypotension. Decreases in aortic nerve activity in response to decreases in mean arterial pressure were not different during CGRP and SNP infusion. Progressive infusion of CGRP (12-120 pmol.kg-1.min-1) increased RNSA by 83 +/- 14 (me

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34

Cui, Jian, Thad E. Wilson, and Craig G. Crandall. "Baroreflex modulation of sympathetic nerve activity to muscle in heat-stressed humans." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 282, no. 1 (2002): R252—R258. http://dx.doi.org/10.1152/ajpregu.00337.2001.

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To identify whether whole body heating alters arterial baroreflex control of muscle sympathetic nerve activity (MSNA), MSNA and beat-by-beat arterial blood pressure were recorded in seven healthy subjects during acute hypotensive and hypertensive stimuli in both normothermic and heat stress conditions. Whole body heating significantly increased sublingual temperature ( P < 0.01), MSNA ( P < 0.01), heart rate ( P< 0.01), and skin blood flow ( P < 0.001), whereas mean arterial blood pressure did not change significantly ( P > 0.05). During both normothermic and heat stress conditi

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35

Gause, G. E., R. Baker, and S. Cassin. "Specificity of FPL 57231 for leukotriene D4 receptors in fetal pulmonary circulation." American Journal of Physiology-Heart and Circulatory Physiology 254, no. 1 (1988): H120—H125. http://dx.doi.org/10.1152/ajpheart.1988.254.1.h120.

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The effects of leukotriene D4 and the putative leukotriene receptor antagonist FPL 57231 were studied on the pulmonary circulation of alpha-chloralose-anesthetized fetal lambs close to term. At constant pulmonary inflow leukotriene D4 (LTD4, 0.1-10 micrograms), as bolus injections, caused dose-dependent increases in pulmonary vascular resistance. FPL 57231 (1.0-10 mg/kg) not only blocked the pressor responses to LTD4 but also lowered the normal pulmonary vascular resistance in a dose-dependent fashion. However, FPL 57231 also decreased the pulmonary pressor response to U 46619, a thromboxane A

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36

Cieri, Ugo R. "Determination of Phenylephrine Hydrochloride, Chlorpheniramine Maleate, and Methscopolamine Nitrate in Tablets or Capsules by Liquid Chromatography with Two UV Absorbance Detectors in Series." Journal of AOAC INTERNATIONAL 89, no. 1 (2006): 53–57. http://dx.doi.org/10.1093/jaoac/89.1.53.

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Abstract A procedure is presented for the simultaneous determination of phenylephrine HCl (PE), chlorpheniramine maleate (CM), and methscopolamine nitrate in commercial tablets or capsules by liquid chromatography (LC) with 2 UV absorbance detectors in series. Reference and sample solutions are prepared in methanol. LC separations are performed on a 7.5 cm Novapak silica column. The mobile phase is prepared by mixing 930 mL methanol with 70 mL of a 0.5% aqueous solution of 1-pentanesulfonic acid, sodium salt. The injection volume is 20 L; the flow rate is approximately 1 mL/min. Retention time

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37

Hellyer, Peter W., Richard M. Bednarski, John A. E. Hubbell, and William W. Muir. "Effects of halothane and isoflurane on baroreflex sensitivity in horses." American Journal of Veterinary Research 50, no. 12 (1989): 2127–34. https://doi.org/10.2460/ajvr.1989.50.12.2127.

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SUMMARY Baroreflex sensitivity (bs) was used to quantitatively assess the effects of halothane and isoflurane on the heart rate/arterial pressure relationship during steady-state (10 minutes) and dynamic pressure changes in adult horses. Arterial pressure was decreased in response to nitroglycerin or sodium nitroprusside and increased in response to phenylephrine HCl. Mean (± sem) bs in awake horses was 28.9 ± 2.6 and 13.2 ± 2.0 ms/mm of Hg during steady-state decreases and increases in systolic arterial pressure (sap), respectively. Halothane and isoflurane either significantly (P < 0.05)

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38

Kenenna, Obiatuegwu, Atim Terkaa, Magnus Felix, Otabor Christopher, Amu Okwudili, and Abu Sadiq. "OuadMix Penile Injection: An Initial Urologists Experience." International Journal of Clinical Urology 9, no. 1 (2025): 73–79. https://doi.org/10.11648/j.ijcu.20250901.22.

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&lt;i&gt;Introduction&lt;/i&gt;: QuadMix is considered to be one of the most powerful class of anti-erectile dysfunction agents and superior to all forms of intracavernosal injections especially in men with permanent/severe erectile dysfunction (ED) that has defiled oral therapy. QuadMix consists of papaverine HCl, phentolamine mesylate, prostaglandin E1 and atropine sulfate designed to act synergistically with satisfactory endpoint. We report our preliminary experience with QuadMIX in the management of permanent/severe ED. &lt;i&gt;Methodology&lt;/i&gt;: This i

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39

Sun, Yun-Yun, Shi-Fei Wei, Shi-Ming Li, et al. "Cycloplegic refraction by 1% cyclopentolate in young adults: is it the gold standard? The Anyang University Students Eye Study (AUSES)." British Journal of Ophthalmology 103, no. 5 (2018): 654–58. http://dx.doi.org/10.1136/bjophthalmol-2018-312199.

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AimsTo document the difference between non-cycloplegic and cycloplegic refraction and explore its associated factors in Chinese young adults. MethodsA school-based study including 7971 undergraduates was conducted in Anyang, Henan Province, China. Cycloplegia was achieved with two drops of 1% cyclopentolate and 1 drop of Mydrin P (Tropicamide 0.5%, phenylephrine HCl 0.5%) with a 5 min interval. Non-cycloplegic and cycloplegic refractions were measured by an autorefractor. A paired-sample t-test and Spearman correlation analysis were used for analysis with data from only the right eyes included

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40

Hirata, Takahiko, Raymond C. Koehler, Saul W. Brusilow, and Richard J. Traystman. "Preservation of Cerebral Blood Flow Responses to Hypoxia and Arterial Pressure Alterations in Hyperammonemic Rats." Journal of Cerebral Blood Flow & Metabolism 15, no. 5 (1995): 835–44. http://dx.doi.org/10.1038/jcbfm.1995.104.

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Acute hyperammonemia causes cerebral edema, elevated intracranial pressure and loss of cerebral blood flow (CBF) responsivity to CO2. Inhibition of glutamine synthetase prevents these abnormalities. If the loss of CO2 responsivity is secondary to the mechanical effects of edema, one would anticipate loss of responsivity to other physiological stimuli, such as hypoxia and changes in mean arterial blood pressure (MABP). To test this possibility, pentobarbital-anesthetized rats were subjected to either hypoxic hypoxia (Pao2 ≈ 30 mm Hg), hemorrhagic hypotension (MABP ≈70 and 50 mm Hg), or phenylep

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41

KERGOAT, H., J. V. LOVASIK, and M. J. DOUGHTY. "A Pupillographic Evaluation of a Phenylephrine HC1 5% - Tropicamide 0.8% Combination Mydriatic." Journal of Ocular Pharmacology and Therapeutics 5, no. 3 (1989): 199–216. http://dx.doi.org/10.1089/jop.1989.5.199.

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42

Parhizkari, G., R. B. Miller, and C. Chen. "A Stability-Indicating HPLC Method for the Determination of Benzalkonium Chloride in Phenylephrine HCI 10% Ophthalmic Solution." Journal of Liquid Chromatography 18, no. 3 (1995): 553–63. http://dx.doi.org/10.1080/10826079508009256.

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43

Mayerhofer, A., RW Steger, G. Gow, and A. Bartke. "Catecholamines stimulate testicular testosterone release of the immature golden hamster via interaction with alpha- and beta-adrenergic receptors." Acta Endocrinologica 127, no. 6 (1992): 526–30. http://dx.doi.org/10.1530/acta.0.1270526.

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Several lines of evidence suggest that catecholamines are involved in the regulation of the development of the testis. We have therefore investigated the ability of testicular parenchyma (decapsulated pieces of testes) from 18 to 20-day-old golden hamsters to respond to catecholaminergic stimuli in vitro. Norepinephrine and epinephrine, as well as the beta-receptor agonist isoproterenol and the alpha-adrenoreceptor agonist phenylephrine were able to significantly stimulate testicular testosterone production. Dopamine and serotonin were not effective. The stimulatory action of norepinephrine on

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44

Gur, Serap, and Wayne J. G. Hellstrom. "Activation of P2Y1 and P2Y2 nucleotide receptors by adenosine 5′-triphosphate analogues augmented nerve-mediated relaxation of human corpus cavernosum." Canadian Urological Association Journal 3, no. 4 (2013): 314. http://dx.doi.org/10.5489/cuaj.1127.

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Introduction: Adenosine 5′-triphosphate (ATP) is a ubiquitous cellularenergy source. We evaluated the effect of ATP and its analogueson nonadrenergic and noncholinergic relaxation in precontractedhuman corpus cavernosal smooth muscle (HCCSM).Methods: We obtained specimens of human corpus cavernosum(HCC) from patients undergoing penile prosthesis surgery (patientage 46–70 yr, n = 17) with prior approval from the local institutionalreview board. Isolated HCC strips were placed in organbaths containing Krebs solution and functional experiments wereconducted. Immunohistochemical localization studi

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45

HAMEED, Hanan, and Salim ALİ. "Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms." Journal of the Turkish Chemical Society Section A: Chemistry, June 22, 2023, 677–88. http://dx.doi.org/10.18596/jotcsa.1260666.

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This work includes the development of two spectrophotometric methods which are sensitive, accurate, stable, and has good recovery for the determination of phenylephrine-HCl as free form and in the pharmaceutical preparations. In the method (A), phenylephrine is oxidized by potassium permanganate in a basic solution of sodium hydroxide and the bluish-green color of the resulting manganate (MnO 42- ) is measured at wavelength 610 nm, which is linearly proportional to the amount of phenylephrine-HCl. Method (B), is involved the oxidation of phenylephrine-HCl by using an excess amount of N-bromosu

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46

T. M., Kalyankar, S. J. Wadher, M. R. Bodhankar, and Mustasin F. Sayed. "Stability Indicating Simultaneous Estimation of Phenylephrine HCl and Bromhexine HCl in Combined tablet dosage form by UV-Spectrophotometer." Research Journal of Pharmacy and Technology, June 29, 2021, 3128–32. http://dx.doi.org/10.52711/0974-360x.2021.00545.

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A novel simple rapid accurate and precise UV spectrophotometric method for simultaneous estimation of bromhexine hydrochloride (BRH) and phenylephrine hydrochloride (PHE) in combine tablet dosage form have been developed. BRH shows absorbance maxima at 246nm and PHE shows 272nm in distilled water after sonication for 20 min. Beer`s law was obeyed at the range of 4-24µg/ml and 5-30µg/ml by BRH and PHE respectively. The method was validated as per ICH guidelines. The validation study data was found to be statistically significant as all the statistical parameters are within the acceptance range

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47

K. Kareem, Nagham, Mohammed Z. Thani, and Khalid F.Al-Rawi. "New approach for determination of Phenylephrine HCl in Pure and Pharmaceutical Formulation using a various Microextraction Methods." Research Journal of Pharmacy and Technology, April 23, 2022, 1648–52. http://dx.doi.org/10.52711/0974-360x.2022.00275.

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In this study, ion pair reactions used for evaluation of phenylephrine HCl the development of simple, accurate, low-cost, and fast extraction methods for the separation of phenylephrine HCl was described. The first method was used was the direct extraction that included the reaction PHE with Alizarin yellow reagent to produce yellow complex in the acidic medium (pH=4). The absorbance of this complex was 430nm. The concentration range (1-20µg.mL-1), the Beers law was obeyed with correlation coefficient (R2=0.997), limit of detection as (0.34µg.mL-1), limit of quantification as (1.12µg.mL-1) and

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48

Shankar, Ravi, Manish Kumar, and Prabhat Kumar Upadhyay. "Comparative Study on Enhanced Skin Permeation Efficiency of Phenylephrine via Novel Lipid Vesicles: A Promising Approach in Preventing Chemotherapy-Induced Alopecia Management." Current Pharmaceutical Biotechnology 26 (October 18, 2024). http://dx.doi.org/10.2174/0113892010336809240815050316.

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Background: Chemotherapy-induced alopecia (CIA) significantly impacts patients' emotional and psychological well-being and treatment regimen. Phenylephrine, a topical vasoconstrictor, can potentially reduce hair loss by limiting chemotherapy drug delivery to hair follicles. However, effective delivery of Phenylephrine through the skin remains challenging. This study investigates lipid vesicles as delivery vehicles to enhance Phenylephrine's skin permeation and sustained release due to their biocompatibility and encapsulation capabilities. Objective: This study aimed to formulate and compare di

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Al-Fakhry, Maysam H., and Omar A. Sheej Ahmad. "Spectrophotometric Assay for the Determination of Phenylephrine-HCl using Sodium Nitroprusside and Hydroxylamine Hydrochloride as a reagents." Research Journal of Pharmacy and Technology, January 27, 2023, 169–74. http://dx.doi.org/10.52711/0974-360x.2023.00031.

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This study addressed a straightforward, precise and easy spectrophotometric method to determine phenylephrine hydrochloride (PHP) in bulk and pharmaceuticals dosage (drops and syrup). This method involves the interaction of sodium nitroprusside (SNP) with phenylephrine hydrochloride and hydroxylamine hydrochloride (HAH) in a phosphate buffer solution (pH 12) to produce a green color product. The overlain spectra of the product showed maximum PHP absorption at 714nm. The absorbance was started to increase linearly with the increased concentration of PHP. Under the optimal conditions, Beer’s law

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50

Gelotte, Cathy K., Dolly A. Parasrampuria, and Brenda A. Zimmerman. "Single-Dose Pharmacokinetics and Metabolism of the Oral Decongestant Phenylephrine HCl in Children and Adolescents." Pulmonary Therapy, December 8, 2022. http://dx.doi.org/10.1007/s41030-022-00206-8.

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