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Статті в журналах з теми "Pnhn"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 18 лютого 2022

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1

Coppola, Luigi, Sergio Lorenzi, Stefano Garlati, and Patricia Kara. "The Rheological and Mechanical Performances of Concrete Manufactured with Blended Admixtures Based on Phosphonates." Key Engineering Materials 674 (January 2016): 159–64. http://dx.doi.org/10.4028/www.scientific.net/kem.674.159.

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The paper deals with the effectiveness of blended phosphonate-based superplasticizers (PHN) for ready mixed concrete. Two phosphonates (PNH1 and PNH2) were added in different percentage to naphthalene sulphonate (NSF) or polycarboxylates (PCEs) based admixtures to improve both compatibility with different cements and workability retention of concrete. The performance of the obtained concrete mixtures was compared to concretes manufactured with the pure NSF or PCE based admixtures. Concretes with the same initial workability (flow table > 580mm) were produced at a temperature of 20 °C and 30

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2

WOOD, CHRIS M., R. S. MUNGER, and D. P. TOEWS. "Ammonia, Urea and H+ Distribution and the Evolution of Ureotelism in Amphibians." Journal of Experimental Biology 144, no. 1 (1989): 215–33. http://dx.doi.org/10.1242/jeb.144.1.215.

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In theory, the distribution of ammonia across cell membranes (Tammi/Tamme) between intracellular and extracellular fluids (ICF and ECF) may be determined by the transmembrane pH gradient (as in mammals), the transmembrane potential (as in teleost fish), or both, depending on the relative permeability of the membranes to NH3 and NH4+ (pNH3/pNH4+). The resting distributions of H+ (via [14C]DMO), ammonia and urea between plasma and skeletal muscle, and the relative excretion rates of ammonia-N and urea-N, were measured in five amphibian species (Bufo marinus, Ambystoma tigrinum, Rana catesbeiana,

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3

Caciagli, Piero, Vicente Medina Piles, Daniele Marian, et al. "Virion Stability Is Important for the Circulative Transmission of Tomato Yellow Leaf Curl Sardinia Virus by Bemisia tabaci, but Virion Access to Salivary Glands Does Not Guarantee Transmissibility." Journal of Virology 83, no. 11 (2009): 5784–95. http://dx.doi.org/10.1128/jvi.02267-08.

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ABSTRACT The capsid protein (CP) of the monopartite begomovirus Tomato yellow leaf curl Sardinia virus (TYLCSV), family Geminiviridae, is indispensable for plant infection and vector transmission. A region between amino acids 129 and 152 is critical for virion assembly and insect transmissibility. Two previously described mutants, one with a double Q129P Q134H mutation (PNHD) and another with a further D152E change (PNHE), were found nontransmissible (NT). Another NT mutant with a single N130D change (QDQD) was retrieved from a new mutational analysis. In this study, these three NT mutants and

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4

NEMÉNYI, András, Éva STEFANOVITSNÉ-BÁNYAI, Zoltán PÉK, et al. "Total Antioxidant Capacity and Total Phenolics Content of Phyllostachys Taxa Shoots." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 43, no. 1 (2015): 64–69. http://dx.doi.org/10.15835/nbha4319586.

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Total phenolic content (TP) and total antioxidant capacity (AC) were analysed in shoots of Phyllostachys aureosulcata (PA), P aureosulcata f. aureocaulis (PAA), P. aureosulcata f. spectabilis (PAS), P. bissetii (PB), P. flexuosa (PF), P. humilis (PH), P. iridescens (PI), P. nigra var. nigra (PNN), P. nigra var. henonis (PNH), P. mannii (PM), P. sulphurea var. sulphurea (PSS), P. violascens (PVI), P. viridiglaucescens (PVG), P. vivax f. aureocaulis (PVA), collected on four harvest dates. Both TP and AC were determined following three processing methods, fresh, boiled and pickled in shoots of PF

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5

Simon, E. E., B. Fry, K. Hering-Smith, and L. L. Hamm. "Ammonia loss from rat proximal tubule in vivo: effects of luminal pH and flow rate." American Journal of Physiology-Renal Physiology 255, no. 5 (1988): F861—F867. http://dx.doi.org/10.1152/ajprenal.1988.255.5.f861.

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The roles of luminal pH and flow rate in determining ammonia loss from proximal tubules perfused with solutions containing 10 mM NH4Cl were examined using in vivo microperfusion. Perfusate bicarbonate concentration was varied between 5, 25, and 40 mM in tubules perfused at 50 nl/min. As expected, ammonia loss from the 25 or 40 mM bicarbonate-containing perfusates was greater than from that containing 5 mM bicarbonate. Furthermore, there was a correlation between ammonia loss and the log mean luminal bicarbonate concentration (r = 0.39, P less than 0.01). From the collected fluid ammonia and bi

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6

Crookes, David Z. "Nabokov's Pnin." Explicator 47, no. 1 (1988): 33–34. http://dx.doi.org/10.1080/00144940.1988.9933875.

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7

Ainscough, Eric W., Andrew M. Brodie, Scott L. Ingham, and Joyce M. Waters. "Reactivity of triosmium clusters with substituted triphenylphosphines: the crystal and molecular structure of [HOs3(CO)9(2-PNH)] (2-PNH2 = 2-aminophenyldiphenylphosphine)." Journal of Organometallic Chemistry 468, no. 1-2 (1994): 229–34. http://dx.doi.org/10.1016/0022-328x(94)80054-5.

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8

Lu, Hui Bin, K. J. Jin, Kun Zhao, et al. "Fabrication and Characteristic Investigation of Multifunctional Oxide p-n Heterojunctions." Advances in Science and Technology 45 (October 2006): 2582–87. http://dx.doi.org/10.4028/www.scientific.net/ast.45.2582.

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A series of all-perovskite oxide p-n heterojunctions (PNHs) as well as perovskite oxide and Si PNHs have been fabricated by a laser molecular-beam epitaxy. The good nonlinear and rectifying I-V characteristics in the PNHs, unusual and high sensitivity of positive magnetoresistance in low magnetic field in SrNbxTi1-xO3/La1-ySryMnO3 and La1-xSrxMnO3/Si PNHs, ps orders ultrafast photoelectric effect in La1-xSrxMnO3/Si PNHs, as well as ferroelectric property due to the interface enhancement in BaNb0.3Ti0.7O3/Si PNHs have been observed. It is expected that the further investigation on the PNHs coul

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9

Yang, Linfei, Xiao Yu, and Yongchao Yang. "Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms." Endocrine Connections 7, no. 12 (2018): 1299–307. http://dx.doi.org/10.1530/ec-18-0356.

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Although the upregulation of autotaxin (ATX) is associated with many solid tumours, its role in pancreatic neuroendocrine neoplasms (pNEN) has not been well elucidated. The expression of ATX in pNEN tissues and pNEN cell line BON1 was analysed by Western blot, PCR and immunocytochemistry upon exposure to interleukin-6 (IL-6). Additionally, pNEN cell line BON1 was transfected with siRNAs against ATX or signal transducer and activator of transcription 3 (STAT3) and assessed by in vitro invasion assays. The following results were obtained. The expression of ATX in pNEN tissues was significantly i

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10

Sin, Sang-Hoon, and Ju-Hyun Yoo. "Microstructure and Piezoelectric Properties of Low Temperature Sintering PMW-PNN-PZT-BF Ceramics According to PNN Substitution." Journal of the Korean Institute of Electrical and Electronic Material Engineers 29, no. 2 (2016): 90–94. http://dx.doi.org/10.4313/jkem.2016.29.2.90.

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11

Yoo, Ju-Hyun, Kook-Jin Kim, Yeong-Ho Jeong, and Su-Ho Lee. "Piezoelectric and Dielectric Characteristics of Low Loss Low Temperature Sintering PMN-PNN-PZT Ceramics with the amount of PNN Substitution." Journal of the Korean Institute of Electrical and Electronic Material Engineers 20, no. 9 (2007): 766–70. http://dx.doi.org/10.4313/jkem.2007.20.9.766.

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12

Urick, Tonia, Chien I-Chang, Ellen Arena, WenLian Xu, Maurice J. Bessman, and Carmel G. Ruffolo. "The pnhA Gene of Pasteurella multocida Encodes a Dinucleoside Oligophosphate Pyrophosphatase Member of the Nudix Hydrolase Superfamily." Journal of Bacteriology 187, no. 16 (2005): 5809–17. http://dx.doi.org/10.1128/jb.187.16.5809-5817.2005.

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ABSTRACT The pnhA gene of Pasteurella multocida encodes PnhA, which is a member of the Nudix hydrolase subfamily of dinucleoside oligophosphate pyrophosphatases. PnhA hydrolyzes diadenosine tetra-, penta-, and hexaphosphates with a preference for diadenosine pentaphosphate, from which it forms ATP and ADP. PnhA requires a divalent metal cation, Mg2+ or Mn2+, and prefers an alkaline pH of 8 for optimal activity. A P. multocida strain that lacked a functional pnhA gene, ACP13, was constructed to further characterize the function of PnhA. The cellular size of ACP13 was found to be 60% less than t

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13

Rosse, Wendell F. "Epidemiology of PNH." Lancet 348, no. 9027 (1996): 560. http://dx.doi.org/10.1016/s0140-6736(05)64792-7.

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14

Shim, Hyeon Bo, and Jae W. Hahn. "Plasmonic near-field scanning nanoscope with a cross-polarization detection technique." Nanophotonics 8, no. 10 (2019): 1731–38. http://dx.doi.org/10.1515/nanoph-2019-0132.

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AbstractA cross-polarization detection technique was introduced to enhance the signal-to-noise ratio (SNR) of a plasmonic near-field scanning nanoscope (PNSN) using the anisotropic reflection from a metallic ridge nano-aperture. Assuming that the nano-aperture is an resistor-inductor-capacitor-equivalent circuit, we propose an analytic circuit model to quantitatively predict the relationship between the copolarization and cross-polarization signals of the PNSN. It was found that the magnitude of the cross-polarization signal has an opposite trend with respect to the copolarization signal, prov

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15

Schimmack, Simon, Yongchao Yang, Klaus Felix, et al. "C-reactive protein (CRP) promotes malignant properties in pancreatic neuroendocrine neoplasms." Endocrine Connections 8, no. 7 (2019): 1007–19. http://dx.doi.org/10.1530/ec-19-0132.

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Objective Elevated pre-operative C-reactive protein (CRP) serum values have been reported to be associated with poor overall survival for patients with pancreatic neuroendocrine neoplasms (pNEN). The aim of this study was to identify mechanisms linking CRP to poor prognosis in pNEN. Methods The malignant properties of pNENs were investigated using the human pNEN cell-lines BON1 and QGP1 exposed to CRP or IL-6. Analyses were performed by ELISA, Western blot, flow cytometry and immunocytochemistry as well as invasion and proliferation assays. To compare cytokine profiles and CRP levels, 76 serum

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16

Feng, Mengyu, Jiangdong Qiu, Zhe Cao, Gang Yang, Yueze Liu, and Taiping Zhang. "Methylation and mRNA analysis of differential genes between primary tumor and liver metastasis in pancreatic neuroendocrine neoplasm." Journal of Clinical Oncology 37, no. 15_suppl (2019): e15689-e15689. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e15689.

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e15689 Background: The liver metastasis of pNEN is rare, and the underlying mechanisms remain unclear. The objective of this study is to compare the DNA methylation status and mRNA expression between primary tumor and liver metastasis in pNEN, aiming to find the potential gene responsible for liver metastasis in pNEN. Methods: The liver metastasis of pNEN is rare, and the underlying mechanisms remain unclear. The objective of this study is to compare the DNA methylation status and mRNA expression between primary tumor and liver metastasis in pNEN, aiming to find the potential genes responsible

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17

Gerald Pacalo, R. E., K. D. Leinenweber, and P. F. McMillan. "Crystal structure of high-pressure PNNH." Acta Crystallographica Section A Foundations of Crystallography 52, a1 (1996): C536. http://dx.doi.org/10.1107/s0108767396078130.

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18

Inabe, Yasunobu, Toshio Hayashi, Tadakatsu Kimura, and Masaaki Tanabe. "A pulse-driven PNPN switch circuit." Electronics and Communications in Japan (Part II: Electronics) 70, no. 3 (1987): 37–45. http://dx.doi.org/10.1002/ecjb.4420700304.

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19

Mori, Haruo, Kazuo Hagimura, and Tetsuji Imai. "Optically coupled high-voltage pnpn switches." Electrical Engineering in Japan 105, no. 4 (1985): 133–41. http://dx.doi.org/10.1002/eej.4391050417.

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20

Zhu, Feida, Chaowei Fang, and Kai-Kuang Ma. "PNEN: Pyramid Non-Local Enhanced Networks." IEEE Transactions on Image Processing 29 (2020): 8831–41. http://dx.doi.org/10.1109/tip.2020.3019644.

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21

Guo, Der-Feng. "pnpn and npn Heterostructural Optoelectronic Devices." ECS Transactions 28, no. 4 (2019): 105–10. http://dx.doi.org/10.1149/1.3377106.

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22

Besemeres, Mary. "Self‐translation in Vladimir Nabokov's Pnin." Russian Review 59, no. 3 (2000): 390–407. http://dx.doi.org/10.1111/0036-0341.00129.

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23

Hara, K., K. Kojima, K. Mitsunaga, and K. Kyuma. "AlGaAs-GaAs pnpn differential optical switch." IEEE Journal of Quantum Electronics 28, no. 5 (1992): 1335–42. http://dx.doi.org/10.1109/3.135274.

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24

van Bijnen, Sandra, Konnie Hebeda, and Petra Muus. "Bone Marrow Histology in Patients with Paroxysmal Nocturnal Hemoglobinuria." Blood 114, no. 22 (2009): 4215. http://dx.doi.org/10.1182/blood.v114.22.4215.4215.

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Abstract Abstract 4215 Introduction Paroxysmal Nocturnal Hemoglobinuria (PNH) is a disease of the hematopoietic stem cell (HSC) resulting in a clone of hematopoietic cells deficient in glycosyl phosphatidyl inositol anchored proteins. The clinical spectrum of PNH is highly variable with classical hemolytic PNH at one end, and PNH in association with aplastic anemia (AA/PNH) or other bone marrow failure states at the other end. It is still largely unknown what is causing these highly variable clinical presentations. Immune-mediated marrow failure has been suggested to contribute to the developm

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25

Kwoun, Woo Jae, Jeong-Yeal Ahn, Ja Young Seo, et al. "Evaluation of Clinical Usefulness of Monocyte Gating Using CD14 and CD64 for Detecting PNH Clone By Flow Cytometry." Blood 132, Supplement 1 (2018): 4947. http://dx.doi.org/10.1182/blood-2018-99-111468.

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Abstract Introduction Flow cytometry is the gold standard in diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) by detecting the absence of glycol-phosphatidyl inositol (GPI)-linked protein expression on red blood cell, granulocyte, and monocyte. The current assays are 4-color analyses of GPI-linked markers such as fluorescein-labeled proaerolysin (FLAER), CD24, CD14, CD59, and CD235a and the lineage markers for granulocyte (CD15) and monocyte (CD64) cells to detect PNH clones. We investigated the utility of CD14/CD64 monocyte gating by comparing with CD45/light scatter (LS) gating in PNH

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26

Chow, FL, SE Hall, WF Rosse, and MJ Telen. "Separation of the acetylcholinesterase-deficient red cells in paroxysmal nocturnal hemoglobinuria." Blood 67, no. 4 (1986): 893–97. http://dx.doi.org/10.1182/blood.v67.4.893.893.

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Abstract Blood of patients with paroxysmal nocturnal hemoglobinuria (PNH) most often contains two or more populations of erythrocytes--one population with normal sensitivity to lysis by complement (PNH I cells) and a second population of moderately abnormal cells (PNH II cells) or markedly abnormal cells (PNH III cells). PNH II and III cells exhibit moderately and markedly increased sensitivity to lysis by complement, respectively, as well as other membrane defects. We have devised a method for isolating pure, intact PNH II and III cells from mixed populations by use of monoclonal antibodies a

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27

Chow, FL, SE Hall, WF Rosse, and MJ Telen. "Separation of the acetylcholinesterase-deficient red cells in paroxysmal nocturnal hemoglobinuria." Blood 67, no. 4 (1986): 893–97. http://dx.doi.org/10.1182/blood.v67.4.893.bloodjournal674893.

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Blood of patients with paroxysmal nocturnal hemoglobinuria (PNH) most often contains two or more populations of erythrocytes--one population with normal sensitivity to lysis by complement (PNH I cells) and a second population of moderately abnormal cells (PNH II cells) or markedly abnormal cells (PNH III cells). PNH II and III cells exhibit moderately and markedly increased sensitivity to lysis by complement, respectively, as well as other membrane defects. We have devised a method for isolating pure, intact PNH II and III cells from mixed populations by use of monoclonal antibodies and cell a

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28

Noji, Hideyoshi, Tatsuyuki Kai, Masatoshi Okamoto, et al. "Changes of Clonality of Paroxysmal Nocturnal Hemoglobinuria (PNH) Clones during Clinical Courses in Patients with PNH." Blood 110, no. 11 (2007): 3677. http://dx.doi.org/10.1182/blood.v110.11.3677.3677.

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Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematological disorder, in which almost all hematopoietic cells lack glycosylphosphatidylinositol (GPI)-anchored proteins due to phosphatidylinositol glycan-class A (PIG-A) gene abnormalities at the level of hematopoietic stem cells. It has been reported that several minor PNH clones in patients with aplastic anemia and myelodysplastic syndromes occur at random during the clinical course (Okamoto M et al, Leukemia, 2006), while one or more major PNH clones in patients with typical PNH continue to exist during their clinical cour

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29

Narita, Atsushi, Hideki Muramatsu, Yusuke Okuno, et al. "Development of Paroxysmal Nocturnal Hemoglobinuria in Children with Aplastic Anemia." Blood 128, no. 22 (2016): 1499. http://dx.doi.org/10.1182/blood.v128.22.1499.1499.

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Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disease of hematopoietic stem cells resulting from a somatic mutation in the PIGA gene. PNH frequently manifests in association with aplastic anemia (AA), in which PIGA mutations are believed to enable escape from the immune-mediated destruction by pathogenic T cells. Recent studies using next-generation sequencing have revealed that frequent somatic PIGA mutationsin AA patients are associated with a better response to IST and prognosis (Yoshizato et al N Engl J Med. 2015; 373: 35-47). However, clinical P

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30

Lindner, Kirsten, Daniel Binte, Jens Hoeppner, et al. "Resection of Non-Functional Pancreatic Neuroendocrine Neoplasms—A Single-Center Retrospective Outcome Analysis." Current Oncology 28, no. 4 (2021): 3071–80. http://dx.doi.org/10.3390/curroncol28040268.

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Surgery remains the only curative treatment of pancreatic neuroendocrine neoplasms (pNEN). Here, we report the outcome after surgery for non-functional pNEN at a European Neuroendocrine Tumor Society (ENETS) center in Germany between 2000 and 2019; cases were analyzed for surgical (Clavien–Dindo classification; CDc) and oncological outcomes. Forty-nine patients (tumor grading G1 n = 25, G2 n = 22, G3 n = 2), with a median age of 56 years, were included. Severe complications (CDc ≥ grade 3b) occurred in 11 patients (22.4%) and type B/C pancreatic fistulas (POPFs) occurred in 5 patients (10.2%);

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31

Ge, Meili, Jun Shi, Xingxin Li, et al. "Clinical Features and Survival of Asian Pediatric Patients with Paroxysmal Nocturnal Hemoglobinuria: Results from a Single Center in China." Acta Haematologica 134, no. 1 (2015): 1–6. http://dx.doi.org/10.1159/000369773.

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Objective: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease, especially in children. To characterize the clinical presentations and survival, we performed a retrospective analysis of pediatric patients. Methods: We reviewed 55 pediatric patients with PNH referred to our hospital from January 1990 through June 2012 to assess clinical presentations, survival, and differences among subcategories. Results: The overall survival 10 years after diagnosis estimated via the Kaplan-Meier method was 77.6%. The cohort of patients was divided into subcategories of classic PNH, PNH/aplastic anemi

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32

Ninomiya, Haruhiko, Shoko Sato, Yuichi Hasegawa, Hiroshi Kojima, and Toshiro Nagasawa. "PNH-Affected RBC’s Mean Life Span Estimated by Reticulocyte-Gated Flow Cytometry Reflects In Vivo Hemolysis in PNH." Blood 110, no. 11 (2007): 3679. http://dx.doi.org/10.1182/blood.v110.11.3679.3679.

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Abstract The most characteristic clinical feature of PNH is intravascular hemolysis of PNH-affected RBC due to deficiency in the expression of GPI-anchored membrane proteins with complement-regulatory activity, CD55 and CD59. PNH-affected (CD55- and CD59-negative) RBC with complement sensitivity should have a shortened life span due to intravascular hemolysis, although life span of PNH-RBC separately from normal RBC could not be measured, at least clinically in PNH patients. We recently developed a sensitive flow cytometric method to analyse the PNH-phenotype (CD59-negative) in reticulocyte an

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33

Kim, Jin Seok, Jong Wook Lee, Sung-Soo Yoon, et al. "Association Between Elevated Hemolysis at Diagnosis and Early Mortality and Risk of Thrombosis In Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients with Cytopenia." Blood 116, no. 21 (2010): 4241. http://dx.doi.org/10.1182/blood.v116.21.4241.4241.

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Abstract Abstract 4241 Introduction: PNH is a rare, progressive and life threatening disease driven by chronic hemolysis leading to thrombosis, renal impairment, pain, severe fatigue, poor quality of life and premature death. Thrombosis is the leading cause of death (accounting for 40–67% of PNH-related deaths) and was recently identified as a significant risk factor for mortality in Asian PNH patients. Abdominal pain is a common and distressing symptom in PNH and has also been found to be risk factor for thrombosis and mortality in PNH patients. In PNH patients with concomitant aplasia/cytope

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34

UEDA, ETSUKO. "Molecular abnormality in PNH." Nihon Naika Gakkai Zasshi 83, no. 5 (1994): 840–45. http://dx.doi.org/10.2169/naika.83.840.

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35

Brown, Ross. "Laboratory aspects of PNH." Pathology 44 (2012): S33. http://dx.doi.org/10.1016/s0031-3025(16)32676-9.

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36

Röth, A., U. Dührsen, H. Schrezenmeier, and J. Schubert. "Paroxysmale nächtliche Hämoglobinurie (PNH)." DMW - Deutsche Medizinische Wochenschrift 134, no. 09 (2009): 404–9. http://dx.doi.org/10.1055/s-0028-1124013.

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37

Hill, A. "24 PNH: new options." Leukemia Research 33 (May 2009): S20—S21. http://dx.doi.org/10.1016/s0145-2126(09)70023-2.

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38

Sirchia, G., and A. Zanella. "Transfusion of PNH patients." Transfusion 30, no. 5 (1990): 479. http://dx.doi.org/10.1046/j.1537-2995.1990.30590296389.x.

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39

Zhao, Hong, and Sanford Shattil. "Cutaneous thrombosis in PNH." Blood 122, no. 19 (2013): 3249. http://dx.doi.org/10.1182/blood-2013-05-493668.

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40

&NA;. "First therapy for PNH." Oncology Times UK 4, no. 9 (2007): 5. http://dx.doi.org/10.1097/01434893-200709000-00007.

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41

Hamed, Hanan. "Paroxysmal nocturnal hemoglobinuria pnh." Hematology, Transfusion and Cell Therapy 42 (October 2020): 5–6. http://dx.doi.org/10.1016/j.htct.2020.09.010.

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de Latour, Régis Peffault, Jean Yves Mary, Célia Salanoubat, et al. "Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories." Blood 112, no. 8 (2008): 3099–106. http://dx.doi.org/10.1182/blood-2008-01-133918.

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AbstractThe natural history of paroxysmal nocturnal hemoglobinuria (PNH) clinical subcategories (classic PNH and aplastic anemia [AA]/PNH syndrome) is still unknown. We retrospectively studied 460 PNH patients diagnosed in 58 French hematologic centers from 1950 to 2005. The median (SE) follow-up time was 6.8 (0.5) years. The median survival time (SE) was 22 (2.5) years. We identified 113 patients with classic PNH, 224 patients with AA-PNH syndrome, and 93 (22%) intermediate patients who did not fit within these 2 categories. At presentation, classic PNH patients were older, with more frequent

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43

Zhou, Wentao, Yuan Fang, Xu Han, et al. "The Value of Alkaline Phosphatase-to-Albumin Ratio in Detecting Synchronous Metastases and Predicting Postoperative Relapses among Patients with Well-Differentiated Pancreatic Neuroendocrine Neoplasms." Journal of Oncology 2020 (February 6, 2020): 1–8. http://dx.doi.org/10.1155/2020/8927531.

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Backgrounds. Pancreatic neuroendocrine neoplasm (pNEN) is a highly heterogeneous entity, presenting widely varied biological behavior as well as long-term prognosis. Reliable biomarkers are urgently needed to make risk stratifications for pNEN patients, which could be beneficial to the development of individualized therapeutic strategy in the clinical practice. Here, we aimed to evaluate the predictive and prognostic roles of serum alkaline phosphatase-to-albumin ratio (APAR) in well-differentiated pNEN patients. Methods. We retrospectively analyzed the pathologically confirmed grade 1/2 pNEN

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Kim, Eui Joo, Yoon Jae Kim, Hye In Lee, Seok-Hoo Jeong, Hyo Jung Nam, and Jae Hee Cho. "Upregulation of Peroxiredoxin-2 in Well-Differentiated Pancreatic Neuroendocrine Tumors and Its Utility as a Biomarker for Predicting the Response to Everolimus." Antioxidants 9, no. 11 (2020): 1104. http://dx.doi.org/10.3390/antiox9111104.

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Pancreatic neuroendocrine neoplasms (pNENs) account for 2–3% of pancreatic malignancies. Peroxiredoxins (Prdxs), which are major cellular antioxidants, are involved in multiple oncogenic signaling pathways. We investigated the role of peroxiredoxin-2 in QGP-1 human pNEN cell line and patient-derived pNEN tissue. To validate the cancer stem cell-like cell characteristics of QGP-1 cells in spheroid culture, in vitro analyses and xenografting were performed. Furthermore, immunohistochemical staining was conducted to verify the overexpression of Prdx2 in pNEN tissue. Prdx2 expression was high at t

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45

Ren, Xiuxiu, Masakoto Kanezashi, Meng Guo, Rong Xu, Jing Zhong, and Toshinori Tsuru. "Multiple Amine-Contained POSS-Functionalized Organosilica Membranes for Gas Separation." Membranes 11, no. 3 (2021): 194. http://dx.doi.org/10.3390/membranes11030194.

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A new polyhedral oligomeric silsesquioxane (POSS) designed with eight –(CH2)3–NH–(CH2)2–NH2 groups (PNEN) at its apexes was used as nanocomposite uploading into 1,2-bis(triethoxysilyl)ethane (BTESE)-derived organosilica to prepare mixed matrix membranes (MMMs) for gas separation. The mixtures of BTESE-PNEN were uniform with particle size of around 31 nm, which is larger than that of pure BTESE sols. The characterization of thermogravimetric (TG) and gas permeance indicates good thermal stability. A similar amine-contained material of 3-aminopropyltriethoxysilane (APTES) was doped into BTESE to

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Van’t Spijker, Heleen M., Dáire Rowlands, Jean Rossier, Barbara Haenzi, James W. Fawcett, and Jessica C. F. Kwok. "Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation." Neural Plasticity 2019 (October 20, 2019): 1–13. http://dx.doi.org/10.1155/2019/6804575.

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The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of AMPA receptor mobility. Since neuronal pentraxin 2 (Nptx2) is a known regulator of AMPA receptor mobility and Nptx2 can be removed from the neuronal surface by PNN removal, we investigated whether Nptx2 has a function in the PNN. We found that Nptx2 binds to the glycosaminoglycans hyaluronan and chondroitin sulphate E in the PNN. Furthermore, i

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47

Ossipova, Olga, Keiji Itoh, Aurelian Radu, Jerome Ezan, and Sergei Y. Sokol. "Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway." Development 147, no. 17 (2020): dev188094. http://dx.doi.org/10.1242/dev.188094.

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ABSTRACTAmong the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt families. No new classes of extracellular mesoderm-inducing factors have been identified in more than two decades. Here, we show that the pinhead (pnhd) gene encodes a secreted protein that is essential for the activation of a subset of mesodermal markers in the Xenopus embryo. RNA sequencing revealed that many transcriptional targets of Pnhd are shared with those of the FGF p

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Visconte, Valeria, Regis Peffault de Latour, Nalini Raghavachari, et al. "Differential Gene Expression Profile in the T Cell Compartment Between Classic PNH and Aplastic Anemia/PNH Syndrome." Blood 114, no. 22 (2009): 3011. http://dx.doi.org/10.1182/blood.v114.22.3011.3011.

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Abstract Abstract 3011 Poster Board II-987 Somatic mutation of the X- linked gene PIG-A results in partial or absolute deficiency of cell surface expression of glycosylphosphatidylinositol-anchored proteins (GPI-APs). In humans, this genetic event in a hematopoietic stem cell leads to the blood disease paroxysmal nocturnal hemoglobinuria (PNH). PNH has two major clinical presentations: predominantly hemolytic without overt marrow failure, referred to as classic PNH, and PNH clonal expansion in the setting of marrow failure, or the aplastic anemia/PNH syndrome (AA/PNH). The diagnosis of PNH is

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Li, Chin, Ru-Inn Lin, Ming-Chih Lai, Pin Ouyang, and Woan-Yuh Tarn. "Nuclear Pnn/DRS Protein Binds to Spliced mRNPs and Participates in mRNA Processing and Export via Interaction with RNPS1." Molecular and Cellular Biology 23, no. 20 (2003): 7363–76. http://dx.doi.org/10.1128/mcb.23.20.7363-7376.2003.

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ABSTRACT Pnn/DRS protein is associated with desmosomes and colocalizes with splicing factors in nuclear speckled domains. The potential interaction of Pnn with RNPS1, a pre-mRNA splicing factor and a component of the exon-exon junction complex, prompted us to examine whether Pnn is involved in nuclear mRNA processing. By immunoprecipitation, we found that Pnn associates preferentially with mRNAs produced by splicing in vitro. Oligonucleotide-directed RNase H digestion revealed that Pnn binds to the spliced mRNAs at a position immediately upstream of the splice junction and that 5′ splice site

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50

Asad, Mohammad Fahad B., Abhinav Goyal, Hassan Awada, et al. "Extent and Clinical Implications of Subclonal Diversity in Paroxysmal Nocturnal Hemoglobinuria." Blood 130, Suppl_1 (2017): 779. http://dx.doi.org/10.1182/blood.v130.suppl_1.779.779.

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Abstract Paroxysmal Nocturnal hemoglobinuria (PNH) has been traditionally considered a monogenic disease due to somatic mutations in PIGA gene. While selective immune pressure was implicated in PNH evolution via expansion of a PIGA mutant clone in a privileged environment, history of aplastic anemia (AA) is not always present in a manifest hemolytic PNH. Similarly, expansion of PNH clone after AA therapy does not seem to correlate with the strength of immunosuppression and the quality of response. Our initial studies (J.Clin.Invest.2014; 124 :4529-4538) indicated that additional mutational eve

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