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Статті в журналах з теми "Precision health"

Автор: Grafiati
Опубліковано: 22 березня 2025

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1

Olstad, Dana Lee, and Lynn McIntyre. "Reconceptualising precision public health." BMJ Open 9, no. 9 (September 2019): e030279. http://dx.doi.org/10.1136/bmjopen-2019-030279.

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Анотація:
As currently conceived, precision public health is at risk of becoming precision medicine at a population level. This paper outlines a framework for precision public health that, in contrast to its current operationalisation, is consistent with public health principles because it integrates factors at all levels, while illuminating social position as a fundamental determinant of health and health inequities. We review conceptual foundations of public health, outline a proposed framework for precision public health and describe its operationalisation within research and practice. Social position shapes individuals’ unequal experiences of the social determinants of health. Thus, in our formulation, precision public health investigates how multiple dimensions of social position interact to confer health risk differently for precisely defined population subgroups according to the social contexts in which they are embedded, while considering relevant biological and behavioural factors. It leverages this information to uncover the precise and intersecting social structures that pattern health outcomes, and to identify actionable interventions within the social contexts of affected groups. We contend that studies informed by this framework offer greater potential to improve health than current conceptualisations of precision public health that do not address root causes. Moreover, expanding beyond master categories of social position and operationalising these categories in more precise ways across time and place can enrich public health research through greater attention to the heterogeneity of social positions, their causes and health effects, leading to the identification of points of intervention that are specific enough to be useful in reducing health inequities. Failure to attend to this level of particularity may mask the true nature of health risk, the causal mechanisms at play and appropriate interventions. Conceptualised thus, precision public health is a research endeavour with much to offer by way of understanding and intervening on the causes of poor health and health inequities.As currently conceived, precision public health is at risk of becoming precision medicine at a population level. This paper outlines a framework for precision public health that, in contrast to its current operationalization, is consistent with public health principles because it integrates factors at all levels, while illuminating social position as a fundamental determinant of health and health inequities. We review conceptual foundations of public health, outline a proposed framework for precision public health and describe its operationalization within research and practice. Social position shapes individuals’ unequal experiences of the social determinants of health. Thus, in our formulation, precision public health investigates how multiple dimensions of social position interact to confer health risk differently for precisely defined population subgroups according to the social contexts in which they are embedded, while considering relevant biological and behavioural factors. It leverages this information to uncover the precise and intersecting social structures that pattern health outcomes, and to identify actionable interventions within the social contexts of affected groups. We contend that studies informed by this framework offer greater potential to improve health than current conceptualizations of precision public health that do not address root causes. Moreover, expanding beyond master categories of social position and operationalizing these categories in more precise ways across time and place can enrich public health research through greater attention to the heterogeneity of social positions, their causes and health effects, leading to identification of points of intervention that are specific enough to be useful in reducing health inequities. Failure to attend to this level of particularity may mask the true nature of health risk, the causal mechanisms at play and appropriate interventions. Conceptualized thus, precision public health is a research endeavour with much to offer by way of understanding and intervening on the causes of poor health and health inequities.
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2

Gambhir, Sanjiv Sam, T. Jessie Ge, Ophir Vermesh, and Ryan Spitler. "Toward achieving precision health." Science Translational Medicine 10, no. 430 (February 28, 2018): eaao3612. http://dx.doi.org/10.1126/scitranslmed.aao3612.

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3

ten Have, Henk, and Bert Gordijn. "Precision in health care." Medicine, Health Care and Philosophy 21, no. 4 (October 9, 2018): 441–42. http://dx.doi.org/10.1007/s11019-018-9870-x.

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4

Ielapi, Nicola, Michele Andreucci, Noemi Licastro, Teresa Faga, Raffaele Grande, Gianluca Buffone, Sabrina Mellace, Paolo Sapienza, and Raffaele Serra. "Precision Medicine and Precision Nursing: The Era of Biomarkers and Precision Health." International Journal of General Medicine Volume 13 (December 2020): 1705–11. http://dx.doi.org/10.2147/ijgm.s285262.

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5

Khoury, Muin J., Michael F. Iademarco, and William T. Riley. "Precision Public Health for the Era of Precision Medicine." American Journal of Preventive Medicine 50, no. 3 (March 2016): 398–401. http://dx.doi.org/10.1016/j.amepre.2015.08.031.

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6

Branca, Malorye Allison. "TOP PRECISION MEDICINE HEALTH SYSTEMS." Clinical OMICs 8, no. 6 (November 1, 2021): 32–36. http://dx.doi.org/10.1089/clinomi.08.06.21.

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7

Dickson, Victoria Vaughan, and Gail D'Eramo Melkus. "Precision Health in Cardiovascular Conditions." Journal of Cardiovascular Nursing 37, no. 1 (January 2022): 56–57. http://dx.doi.org/10.1097/jcn.0000000000000879.

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8

CHEN, Shu-Ching. "Precision Health in Cancer Care." Journal of Nursing Research 30, no. 2 (April 2022): e194. http://dx.doi.org/10.1097/jnr.0000000000000486.

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9

Kellogg, Ryan A., Jessilyn Dunn, and Michael P. Snyder. "Personal Omics for Precision Health." Circulation Research 122, no. 9 (April 27, 2018): 1169–71. http://dx.doi.org/10.1161/circresaha.117.310909.

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10

Reich, Brian J., and Murali Haran. "Precision maps for public health." Nature 555, no. 7694 (February 28, 2018): 32–33. http://dx.doi.org/10.1038/d41586-018-02096-w.

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11

Mata, Douglas A., Farhan M. Katchi, and Ranjith Ramasamy. "Precision Medicine and Men’s Health." American Journal of Men's Health 11, no. 4 (July 17, 2015): 1124–29. http://dx.doi.org/10.1177/1557988315595693.

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Анотація:
Precision medicine can greatly benefit men’s health by helping to prevent, diagnose, and treat prostate cancer, benign prostatic hyperplasia, infertility, hypogonadism, and erectile dysfunction. For example, precision medicine can facilitate the selection of men at high risk for prostate cancer for targeted prostate-specific antigen screening and chemoprevention administration, as well as assist in identifying men who are resistant to medical therapy for prostatic hyperplasia, who may instead require surgery. Precision medicine-trained clinicians can also let couples know whether their specific cause of infertility should be bypassed by sperm extraction and in vitro fertilization to prevent abnormalities in their offspring. Though precision medicine’s role in the management of hypogonadism has yet to be defined, it could be used to identify biomarkers associated with individual patients’ responses to treatment so that appropriate therapy can be prescribed. Last, precision medicine can improve erectile dysfunction treatment by identifying genetic polymorphisms that regulate response to medical therapies and by aiding in the selection of patients for further cardiovascular disease screening.
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12

Beck, James D., Kamaira Philips, Kevin Moss, Kimon Divaris, Thiago Morelli, and Steven Offenbacher. "Advances in precision oral health." Periodontology 2000 82, no. 1 (December 18, 2019): 268–85. http://dx.doi.org/10.1111/prd.12314.

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13

Feero, W. Gregory. "Introducing “Genomics and Precision Health”." JAMA 317, no. 18 (May 9, 2017): 1842. http://dx.doi.org/10.1001/jama.2016.20625.

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14

Fu, Mei R., Emma Kurnat-Thoma, Angela Starkweather, Wendy A. Henderson, Ann K. Cashion, Janet K. Williams, Maria C. Katapodi, et al. "Precision health: A nursing perspective." International Journal of Nursing Sciences 7, no. 1 (January 2020): 5–12. http://dx.doi.org/10.1016/j.ijnss.2019.12.008.

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15

Akdis, Cezmi A., and Zuhair K. Ballas. "Precision medicine and precision health: Building blocks to foster a revolutionary health care model." Journal of Allergy and Clinical Immunology 137, no. 5 (May 2016): 1359–61. http://dx.doi.org/10.1016/j.jaci.2016.03.020.

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16

Gambhir, Sanjiv S., T. Jessie Ge, Ophir Vermesh, Ryan Spitler, and Garry E. Gold. "Continuous health monitoring: An opportunity for precision health." Science Translational Medicine 13, no. 597 (June 9, 2021): eabe5383. http://dx.doi.org/10.1126/scitranslmed.abe5383.

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Анотація:
Continuous health monitoring and integrated diagnostic devices, worn on the body and used in the home, will help to identify and prevent early manifestations of disease. However, challenges lie ahead in validating new health monitoring technologies and in optimizing data analytics to extract actionable conclusions from continuously obtained health data.
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17

Kosorok, Michael R., and Eric B. Laber. "Precision Medicine." Annual Review of Statistics and Its Application 6, no. 1 (March 7, 2019): 263–86. http://dx.doi.org/10.1146/annurev-statistics-030718-105251.

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Анотація:
Precision medicine seeks to maximize the quality of health care by individualizing the health-care process to the uniquely evolving health status of each patient. This endeavor spans a broad range of scientific areas including drug discovery, genetics/genomics, health communication, and causal inference, all in support of evidence-based, i.e., data-driven, decision making. Precision medicine is formalized as a treatment regime that comprises a sequence of decision rules, one per decision point, which map up-to-date patient information to a recommended action. The potential actions could be the selection of which drug to use, the selection of dose, the timing of administration, the recommendation of a specific diet or exercise, or other aspects of treatment or care. Statistics research in precision medicine is broadly focused on methodological development for estimation of and inference for treatment regimes that maximize some cumulative clinical outcome. In this review, we provide an overview of this vibrant area of research and present important and emerging challenges.
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18

Whitsel, Laurie P., John Wilbanks, Mark D. Huffman, and Jennifer L. Hall. "The Role of Government in Precision Medicine, Precision Public Health and the Intersection With Healthy Living." Progress in Cardiovascular Diseases 62, no. 1 (January 2019): 50–54. http://dx.doi.org/10.1016/j.pcad.2018.12.002.

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19

Meurer, John R., Jeffrey C. Whittle, Kelsey M. Lamb, Matthew A. Kosasih, Melinda R. Dwinell, and Raul A. Urrutia. "Precision Medicine and Precision Public Health: Academic Education and Community Engagement." American Journal of Preventive Medicine 57, no. 2 (August 2019): 286–89. http://dx.doi.org/10.1016/j.amepre.2019.03.010.

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20

Kenney, Martha, and Laura Mamo. "The imaginary of precision public health." Medical Humanities 46, no. 3 (August 16, 2019): 192–203. http://dx.doi.org/10.1136/medhum-2018-011597.

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Анотація:
In recent years, precision medicine has emerged as a charismatic name for a growing movement to revolutionise biomedicine by bringing genomic knowledge and sequencing to clinical care. Increasingly, the precision revolution has also included a new paradigm called precision public health—part genomics, part informatics, part public health and part biomedicine. Advocates of precision public health, such as Sue Desmond-Hellmann, argue that adopting cutting-edge big data approaches will allow public health actors to precisely target populations who experience the highest burden of disease and mortality, creating more equitable health futures. In this article we analyse precision public health as a sociotechnical imaginary, examining how calls for precision shape which public health efforts are seen as necessary and desirable. By comparing the rhetoric of precision public health to precision warfare, we find that precision prescribes technical solutions to complex problems and promises data-driven futures free of uncertainty, unnecessary suffering and inefficient use of resources. We look at how these imagined futures shape the present as they animate public health initiatives in the Global South funded by powerful philanthropic organisations, such as the Bill & Melinda Gates Foundation, as well as local efforts to address cancer disparities in San Francisco. Through our analysis of the imaginary of precision public health, we identify an emerging tension between health equity goals and precision’s technical solutions. Using large datasets to target interventions with greater precision, we argue, fails to address the upstream social determinants of health that give rise to health disparities worldwide. Therefore, we urge caution around investing in precision without a complementary commitment to addressing the social and economic conditions that are the root cause of health inequality.
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21

Tabak, L., E. Green, S. Devaney, and M. Somerman. "Precision Health: Bringing Oral Health into the Context of Overall Health." Advances in Dental Research 30, no. 2 (October 21, 2019): 31–33. http://dx.doi.org/10.1177/0022034519877392.

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Анотація:
Unprecedented advances in genomics, data science, and biotechnology have ushered in a new era of health care in which interventions are increasingly tailored to individual patients. Precision-based approaches extend to oral health, which is essential to overall health. Harnessing the full potential of precision oral health will depend on research to more fully understand the factors that underlie health and contribute to disease—including the human genome, microbiome, epigenome, proteome, and others.
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22

Phillips, Kathryn A. "The Coming Era Of Precision Health." Health Affairs 40, no. 2 (February 1, 2021): 363. http://dx.doi.org/10.1377/hlthaff.2020.02393.

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23

Arnett, Donna K., and Steven A. Claas. "Precision Medicine, Genomics, and Public Health." Diabetes Care 39, no. 11 (October 25, 2016): 1870–73. http://dx.doi.org/10.2337/dc16-1763.

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24

Gubin, D. G., S. N. Kolomeichuk, and D. Weinert. "Circadian clock precision, health, and longevity." Journal of Chronomedicine 23, no. 1 (July 14, 2021): 3–15. http://dx.doi.org/10.36361/2307-4698-2020-23-1-3-15.

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Анотація:
An accurate circadian clock, associated with the precise intrinsic period, tau, can be linked with a definite chronotype and health status. Exemplified by different animal species, and, as we argue herein, may as well be in humans, endogenous tau close enough to 24 hours is associated with higher life expectancy, lower morbidity, and is possibly adhered to moderate morning chronotype. Accurate circadian tau facilitates maintaining a high amplitude of circadian rhythms, a phenotypic trait that is related to health and longevity. Some genetic factors that coordinate tau and ensure circadian clock precision is considered.
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25

Kee, Frank, and David Taylor-Robinson. "Scientific challenges for precision public health." Journal of Epidemiology and Community Health 74, no. 4 (January 23, 2020): 311–14. http://dx.doi.org/10.1136/jech-2019-213311.

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Анотація:
The notion of ‘precision’ public health has been the subject of much debate, with recent articles coming to its defence following the publication of several papers questioning its value.Critics of precision public health raise the following problems and questionable assumptions: the inherent limits of prediction for individuals; the limits of approaches to prevention that rely on individual agency, in particular the potential for these approaches to widen inequalities; the undue emphasis on the supposed new information contained in individuals’ molecules and their ‘big data’ at the expense of their own preferences for a particular intervention strategy and the diversion of resources and attention from the social determinants of health.In order to refocus some of these criticisms of precision public health as scientific questions, this article outlines some of the challenges when defining risk for individuals; the limitations of current theory and study design for precision public health; and the potential for unintended harms.
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26

Dowell, Scott F., David Blazes, and Susan Desmond-Hellmann. "Four steps to precision public health." Nature 540, no. 7632 (December 2016): 189–91. http://dx.doi.org/10.1038/540189a.

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27

Imoto, Seiya, Takanori Hasegawa, and Rui Yamaguchi. "Data science and precision health care." Nutrition Reviews 78, Supplement_3 (November 26, 2020): 53–57. http://dx.doi.org/10.1093/nutrit/nuaa110.

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Анотація:
Abstract Precision health care plays a crucial role in an elderly society by providing personalized health care plans for improving an individual’s health conditions and preventing disease. To realize precision health care, data science is key; it allows for analyses of health-related big data. In this article, an actual analysis of time-series health check-up data is presented and as is a discussion of how personalized simulation models of health conditions are constructed and used to modify individual behavior. Future directions for precision health care based on the integration of genetic variations and the microbiome are also discussed.
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28

Ryan, M. E., and R. Garcia. "Advances in Precision Oral Health Research." Advances in Dental Research 30, no. 2 (October 21, 2019): 28–30. http://dx.doi.org/10.1177/0022034519879059.

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29

Corwin, Elizabeth, Nancy S. Redeker, Therese S. Richmond, Sharron L. Docherty, and Rita H. Pickler. "Ways of knowing in precision health." Nursing Outlook 67, no. 4 (July 2019): 293–301. http://dx.doi.org/10.1016/j.outlook.2019.05.011.

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30

Kuo, Anda K., Nicole M. Summers, Sameer Vohra, Robert S. Kahn, and Kirsten Bibbins-Domingo. "The Promise of Precision Population Health." Advances in Pediatrics 66 (August 2019): 1–13. http://dx.doi.org/10.1016/j.yapd.2019.03.002.

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31

Schumann, Gunter, Vivek Benegal, Chunshui Yu, Sha Tao, Terry Jernigan, Andreas Heinz, Ricardo Araya, Le Yu, and Vince Calhoun. "Precision medicine and global mental health." Lancet Global Health 7, no. 1 (January 2019): e32. http://dx.doi.org/10.1016/s2214-109x(18)30406-6.

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32

Chowkwanyun, Merlin, Ronald Bayer, and Sandro Galea. "Precision public health: pitfalls and promises." Lancet 393, no. 10183 (May 2019): 1801. http://dx.doi.org/10.1016/s0140-6736(18)33187-8.

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33

Dickson, Cameron, and Elina Hyppönen. "Precision health: a primer for physiotherapists." Physiotherapy 107 (June 2020): 66–70. http://dx.doi.org/10.1016/j.physio.2019.08.004.

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34

Terry, Paul E. "Genetic Exceptionalism and Precision Health Promotion." American Journal of Health Promotion 34, no. 7 (March 17, 2020): 709–12. http://dx.doi.org/10.1177/0890117120908806.

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Анотація:
Are social determinants of health overrated? Is parenting overrated? Will the genetics revolution have the same influence on health behavior as powerful determinants such as culture or the environment? In this editorial, I posit that we will learn that genetic testing will have far greater benefits, and fewer harms, when done in conjunction with well-designed health education and lived experiences. I define precision health promotion as the personalized design of lived experiences that foster improved health and well-being for individuals within the context of their organizations, families, and communities. With the need for education and support to augment genetics information will come the need for unequivocal answers about who should know, and who has no business knowing, about your DNA test results.
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35

Khoury, Muin J., and Sandro Galea. "Will Precision Medicine Improve Population Health?" Obstetrical & Gynecological Survey 72, no. 1 (January 2017): 15–17. http://dx.doi.org/10.1097/01.ogx.0000511937.49229.57.

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36

Hull, Susan C. "Are we ready for precision health?" Nursing Management (Springhouse) 49, no. 7 (July 2018): 9–11. http://dx.doi.org/10.1097/01.numa.0000538923.68406.3c.

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37

Khoury, Muin J., and Sandro Galea. "Will Precision Medicine Improve Population Health?" JAMA 316, no. 13 (October 4, 2016): 1357. http://dx.doi.org/10.1001/jama.2016.12260.

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38

Kertay, Les. "Precision Matters in Behavioral Health, Too." Guides Newsletter 23, no. 1 (January 1, 2018): 9. http://dx.doi.org/10.1001/amaguidesnewsletters.2018.janfeb02.

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Анотація:
Abstract Behavioral health terminology is an area beset by imprecision that results from confusing claim determinations, unnecessary evaluations, and poor outcomes that result from inappropriate treatment. In medical evaluation reports, one notes references to depression, anxiety, and stress, which are not diagnoses but often are treated as such. Behavioral factors can affect claims in four ways: the presence of a formal clinical diagnosis that meets specific criteria, psychological symptoms, difficult life circumstances, and behavioral overlays. Only the first of these can be attributed to a workplace injury or illness, and determining a causal relationship requires, at minimum, a precise diagnosis. For example, by depression does the health provider mean major depressive disorder with specifiers, persistent depressive/dysthymic disorder, adjustment disorder with depressed mood, or some other specific condition? The behavioral layers can affect the outcome of the claims process and may or may not be appropriate targets of an evidence-informed intervention aimed at returning an injured or ill worker to a higher level of function. The point is not to argue whether or not behavioral interventions are appropriate in workers’ compensation, personal injury, and other claims; the point, rather, is that precise language is the first, necessary step in sorting out the myriad ways in which behavior affects claim incidence, duration, and cost.
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39

Benakatti, Veena. "Precision dentistry: CRISPR in oral health." IP Annals of Prosthodontics and Restorative Dentistry 11, no. 1 (February 15, 2025): 10–13. https://doi.org/10.18231/j.aprd.2025.003.

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Анотація:
With the technological revolution, precision medicine has become a possible entity in the present times. Genome editing, a genetic engineering tool, has added a new dimension to diagnostics and therapeutics in healthcare. Amongst the genome editing tools, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) stands out for its efficiency, versatility, and precision. CRISPR refers to a genetic scissor that can precisely edit specific parts of DNA accurately and comprises three steps: identification, editing, and repair. CRISPR has seen various applications in medicine from treating genetic and infectious diseases to cancer therapy. In dentistry, CRISPR technology is in its initial stages and has shown potential in periodontitis, dental caries, head and neck cancer, orthodontics, craniofacial defects, and viral infections. CRISPR by host response modulation offers personalized periodontal care, inhibits biofilm formation to prevent dental caries, personalized cancer treatment by targeting responsible genes, provides genetic information on the aetiology of craniofacial malformations, and helps in understanding viral infections and targeted therapies. This customized precision approach opens new avenues to improved treatment outcomes. CRISPR technology is not devoid of challenges, it has ethical challenges, immunogenicity, and off-target effects, yet, it holds promise as a future diagnostic and therapeutic approach if implemented with care.
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40

Griffith, Derek M. "Abstract IA014: Precision public health approaches to health equity." Cancer Prevention Research 16, no. 1_Supplement (January 1, 2023): IA014. http://dx.doi.org/10.1158/1940-6215.precprev22-ia014.

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Abstract Since President Barack Obama announced the “Precision Medicine Initiative” during his state of the union address in January 2015, the sciences of precision medicine and health equity have largely grown in parallel, though there have been some efforts to bring the two together. As research on health equity has evolved to name and consider structural racism, the penultimate goal of research in this area also as moved from efforts to identify and describe gaps between racial and ethnic groups to characterizing the context creates and perpetuates racial inequities and how best to mitigate them. In this presentation, I will briefly describe how syndemics, intersectionality, and individual tailoring may complement downstream efforts to characterize epigenetic and genomic efforts to develop biomedical interventions to achieve healthcare equity and health equity. After noting how the principles of precision medicine may be applied more broadly than the most common way it is operationalized through genomic medicine, I argue that that creating racial justice in health will require defining health equity more clearly and precisely. Consequently, I utilize the example of Black men and the context of COVID-19 to highlight how more precisely defining the structural context of the population of interest by using tools such as intersectionality and syndemics is fundamental to achieving equity. I highlight how achieving health equity will require creating, resisting, undoing, and mitigating structural racism and note what that means for cancer research. Precision medicine may help to mitigate the health effects of structural racism, and it will remain an important tool to promote population health; however, efforts to achieve health equity and racial justice will require interventions that change the contexts and conditions that create, exacerbate, and perpetuate structural inequities and the racial inequities in health outcomes that they produce and maintain. Citation Format: Derek M. Griffith. Precision public health approaches to health equity. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA014.
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41

Myroniuk, Tyler W., Michelle Teti, and Enid Schatz. "Without Qualitative Health Data, Precision Health Will Be Imprecise." International Journal of Qualitative Methods 20 (January 2021): 160940692110454. http://dx.doi.org/10.1177/16094069211045476.

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Patel, Ronak B. "Precision Health in Disaster Medicine and Global Public Health." Prehospital and Disaster Medicine 33, no. 6 (December 2018): 565–66. http://dx.doi.org/10.1017/s1049023x18001061.

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AbstractCurrent debates about precision medicine take different perspectives on its relevance and value in global health. The term has not yet been applied to disaster medicine or humanitarian health, but it may hold significant value. An interpretation of the term for global public health and disaster medicine is presented here for application to vulnerable populations. Embracing the term may drive more efficient use and targeting of limited resources while encouraging innovation and adopting the new approaches advocated in current humanitarian discourse.PatelRB.Precision health in disaster medicine and global public health.Prehosp Disaster Med.2018;33(6):565–566.
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43

Vineeth, Amba, Celly Martins Ribeiro de Souza Marina, Kenner Carole, and Marques Borges Carolina. "Precision health contributions to public health: An integrative review." Journal of Public Health and Epidemiology 10, no. 7 (July 31, 2018): 225–32. http://dx.doi.org/10.5897/jphe2017.0986.

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44

LeMieux, Julianna. "AGBT Precision Health Roundup: In Addition to Success Stories, Attendees Learn About Emerging Areas of Precision Health." Clinical OMICs 5, no. 6 (November 2018): 44–47. http://dx.doi.org/10.1089/clinomi.05.06.22.

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45

Brown, Noah A., and Kojo S. J. Elenitoba-Johnson. "Enabling Precision Oncology Through Precision Diagnostics." Annual Review of Pathology: Mechanisms of Disease 15, no. 1 (January 24, 2020): 97–121. http://dx.doi.org/10.1146/annurev-pathmechdis-012418-012735.

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Genomic testing enables clinical management to be tailored to individual cancer patients based on the molecular alterations present within cancer cells. Genomic sequencing results can be applied to detect and classify cancer, predict prognosis, and target therapies. Next-generation sequencing has revolutionized the field of cancer genomics by enabling rapid and cost-effective sequencing of large portions of the genome. With this technology, precision oncology is quickly becoming a realized paradigm for managing the treatment of cancer patients. However, many challenges must be overcome to efficiently implement the transition of next-generation sequencing from research applications to routine clinical practice, including using specimens commonly available in the clinical setting; determining how to process, store, and manage large amounts of sequencing data; determining how to interpret and prioritize molecular findings; and coordinating health professionals from multiple disciplines.
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46

Porche, Demetrius J. "Precision Medicine Initiative." American Journal of Men's Health 9, no. 3 (March 10, 2015): 177. http://dx.doi.org/10.1177/1557988315574512.

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47

Ryan, Jillian C., John Noel Viana, Hamza Sellak, Shakuntla Gondalia, and Nathan O'Callaghan. "Defining precision health: a scoping review protocol." BMJ Open 11, no. 2 (February 2021): e044663. http://dx.doi.org/10.1136/bmjopen-2020-044663.

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IntroductionPrecision health is a nascent field of research that would benefit from clearer operationalisation and distinction from adjacent fields like precision medicine. This clarification is necessary to enable precision health science to tackle some of the most complex and significant health problems that are faced globally. There is a pressing need to examine the progress in human precision health research in the past 10 years and analyse this data to first, find similarities and determine discordances in how precision health is operationalised in the literature and second, identify gaps and future directions for precision health research.Methods and analysisTo define precision health and map research in this field, a scoping review will be undertaken and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses - Scoping Review Extension guidelines. Systematic searches of scientific databases (Medline, Embase, Scopus, Web of Science and PsycINFO) and grey literature sources (Google Scholar, Google Patents) identified 8053 potentially eligible articles published from 1 January 2010 to 30 June 2020. Following removal of duplicates, a total of 3190 articles were imported for screening. Article data will be extracted using a customised extraction template on Covidence and analysed descriptively using narrative synthesis.Ethics and disseminationEthics approval is not required. Findings will be disseminated through professional networks, conference presentations and publication in a scientific journal.
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Gubin, D. G., and S. N. Kolomeichuk. "CIRCADIAN CLOCK PRECISION, CHRONOTYPE, HEALTH AND LONGEVITY." Journal of Chronomedicine 21, no. 2 (2019): 14–27. http://dx.doi.org/10.36361/2307-4698-2019-21-2-14-27.

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Kolesar, Jill M., and Lee C. Vermeulen. "Precision medicine: Opportunities for health-system pharmacists." American Journal of Health-System Pharmacy 78, no. 11 (March 10, 2021): 999–1003. http://dx.doi.org/10.1093/ajhp/zxab084.

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50

Ollier, William, Kenneth R. Muir, Artitaya Lophatananon, Arpana Verma, and Martin Yuille. "Risk biomarkers enable precision in public health." Personalized Medicine 15, no. 4 (July 2018): 329–42. http://dx.doi.org/10.2217/pme-2017-0068.

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