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Добірка наукової літератури з теми "Proanthocyanidols"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 1 лютого 2022

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Статті в журналах з теми "Proanthocyanidols"

1

Girard, Marion, Annika Lehtimäki, Giuseppe Bee, Frigga Dohme-Meier, Maarit Karonen, and Juha-Pekka Salminen. "Changes in Feed Proanthocyanidin Profiles during Silage Production and Digestion by Lamb." Molecules 25, no. 24 (December 12, 2020): 5887. http://dx.doi.org/10.3390/molecules25245887.

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Proanthocyanidins are plant specialized metabolites which are beneficial to animal nutrition and health. This study determined how proanthocyanidin profiles of sainfoin (Onobrychis viciifolia) and birdsfoot trefoil (Lotus corniculatus) change during the forage conservation process and along the digestive tract of lamb. We determined soluble, protein- and fiber-bound proanthocyanidins by spectrophotometric methods and soluble proanthocyanidin profiles by UPLC-MS/MS. During the conservation process, the total proanthocyanidin contents reduced in both forages and the relative proportion of insoluble proanthocyanidins increased, especially in sainfoin. The soluble proanthocyanidins, their mean degree of polymerization and the relative prodelphinidin share declined in both feed species. In the abomasum of lambs fed sainfoin silage, most of the proanthocyanidins were in insoluble form bound to proteins and fibers, but in the small and large intestines, the proportion of soluble proanthocyanidins increased again. For lambs fed birdsfoot trefoil, the trend was not so clear as proanthocyanidins were already mainly soluble in the abomasum. Nevertheless, a large part of soluble proanthocyanidins was recovered in the digestive tract but could not be detected by the UPLC-MS/MS method used. This study suggests that proanthocyanidins have probably been metabolized in the digestive tract by the resident microbiota.
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2

Liu, Zhi Qiang, Qing Li Yang, Chu Shu Zhang, Yan Zhang, Shi Qing Wang, and Jie Sun. "Study on Antioxidant Activity of Proanthocyanidins from Peanut Skin." Advanced Materials Research 197-198 (February 2011): 1582–86. http://dx.doi.org/10.4028/www.scientific.net/amr.197-198.1582.

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Анотація:
The research aimed to provide scientific basis for developing Proanthocyanidins from peanut skin. In this study, the antioxidant activity of Proanthocyanidins form peanut skin was studied at different system (O2-•, •OH and DPPH•) in vitro, with Vc. For O2-•, •OH and DPPH•, the IC50 of Proanthocyanidins form peanut skin was 0.143mg/mL, 0.097mg/mL and 0.274mg/mL; the IC50 of Vc was 0.163mg/mL, 0.097mg/mL and 0.306mg/mL. The result showed that proanthocyanidins from peanut skin had stronger antioxidant activity than Vc, and that Proanthocyanidins would be a effective natural free radical scavenger.
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3

Zhao, Wen, Yuc Cai Meng, Zhi Ping Yin, Wei Hua Liu, and Cui Jiao Niu. "Study on the Isolation and Purification of Proanthocyanidins from Rhodiola Rose by Macroporous Adsorbent Resin." Advanced Materials Research 236-238 (May 2011): 2053–57. http://dx.doi.org/10.4028/www.scientific.net/amr.236-238.2053.

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Анотація:
Five different macroreticular resins (S-8, HPD750, AB-8, HPD100 and D101) were evaluated for the adsorption properties of the proanthocyanidins extracted from Rhodiola rose. The results showed that AB-8 displayed the optimal adsorption and desorption properties. The adsorption of AB-8 for proanthocyanidins followed Langmuir equation and belonged monolayer adsorption. The optimal purification conditions were as follows: the sample concentration of proanthocyanidins was 4mg/mL, sample flow rate was 1.5BV/h, proanthocyanidins could be entirely eluted with 3 bed volumes of 50% ethanol. Based on the experiment, the purity of proanthocyanidins product is 64%.
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4

Chen, X., J. Xiong, Q. He, and F. Wang. "Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii." Journal of Chemistry 2019 (March 3, 2019): 1–9. http://dx.doi.org/10.1155/2019/4793047.

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Анотація:
Proanthocyanidins in ethanol extracts from the barks of Acacia mangium and Larix gmelinii were analyzed by gel permeation chromatography, MALDI-TOF/TOF MS, and HPLC/MS. The inhibitory effects of proanthocyanidins and acid-catalyzed hydrolysis of proanthocyanidins against carbolytic enzymes were also tested. A significant relationship between carbolytic enzymes inhibition and degree of polymerization was established, showing that the degree of polymerization is a major contributor to the biological activity of the proanthocyanidins from both types of woody plant bark. The results indicate that proanthocyanidins from the barks of A. mangium and L. gmelinii have potential antidiabetic properties.
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Levdansky, Vladimir Aleksandrovich, Irina Vladimirovna Korol'kova, Aleksandr Vladimirovich Levdanskiy, and Boris Nikolayevich Kuznetsov. "ISOLATION AND STUDY OF PROANTHOCYANIDINS FROM BARK OF PINE PÍNUS SYLVÉSTRIS L." chemistry of plant raw material, no. 4 (December 21, 2020): 227–33. http://dx.doi.org/10.14258/jcprm.2020047749.

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Анотація:
The isolation of proanthocyanidins from bark of Scotch pine Pínus sylvéstris L. by water and water-alcohol solutions containing 5, 10, 15, 20 and 25% ethanol was studied for the first time. Isolation of proanthocyanidins was carried out from the initial and deresinified (extracted with hexane) pine bark. It was shown that, compared with water extraction, the use of 15–25% aqueous ethanol solutions allows one to increase the yield of proanthocyanidins from 0.44 to 0.63%. It was established that the preliminary extraction of resinous substances from the pine bark does not significantly affect the yield of proanthocyanidins. It was shown that an increase in ethanol concentration of more than 20% in the extraction solution leads to an increase in the total yield of extractives, while the yield of proanthocyanidins does not increase. A study of proanthocyanidins by UV spectroscopy after their conversion to red anthocyanidins showed that they mainly consist of procyanidin and prodelphinidine in close concentrations. The composition of the obtained proanthocyanidins mixtures was studied by IR and 13C NMR spectroscopy. It was shown that the proanthocyanidins obtained from the bark of pine Pínus sylvéstris L., in contrast to isolated from other pine species, contains gallic acid residues which can increase their antiradical activity.
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6

Ni, Liwen, Fanbin Zhao, Bolun Li, Tong Wei, Hang Guan, and Shixue Ren. "Antioxidant and Fluorescence Properties of Hydrogenolyzised Polymeric Proanthocyanidins Prepared Using SO42−/ZrO2 Solid Superacids Catalyst." Molecules 23, no. 10 (September 25, 2018): 2445. http://dx.doi.org/10.3390/molecules23102445.

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Анотація:
Larix bark oligomeric proanthocyanidins (LOPC) were prepared from larix bark polymeric proanthocyanidins (LPPC) by catalytic hydrogenolysis using SO42−/ZrO2 solid superacid as the catalyst. The catalyst to polymeric proanthocyanidins ratio was 0.2:1 (m/m). The LOPC, obtained after hydrogenolysis at 100 °C for 4 h under 3 MPa hydrogen pressure, retained the structural characteristics of proanthocyanidins. The average degree of polymerization was reduced from 9.50% to 4.76% and the depolymerization yield was 53.85%. LOPC has good antioxidant properties and, at the same concentration, the reducing ability of LOPC was much higher than that of LPPC. The IC50 values of LOPC for scavenging DPPH• and ABTS•+ radicals were 0.046 mg/mL and 0.051 mg/mL, respectively. LOPC is biocompatible and has fluorescent properties that are affected by external factors, such as solvent polarity, pH and the presence of different metal ions. These features indicate that LOPC could be developed as a new biological fluorescent marker. The depolymerization of low-value polymeric proanthocyanidins to provide high-value oligomeric proanthocyanidins and the development of new applications for proanthocyanidins represent significant advances.
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7

Yu, Dan, Ting Huang, Bin Tian, and Jicheng Zhan. "Advances in Biosynthesis and Biological Functions of Proanthocyanidins in Horticultural Plants." Foods 9, no. 12 (November 30, 2020): 1774. http://dx.doi.org/10.3390/foods9121774.

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Анотація:
Proanthocyanidins are colorless flavonoid polymers condensed from flavan-3-ol units. They are essential secondary plant metabolites that contribute to the nutritional value and sensory quality of many fruits and the related processed products. Mounting evidence has shown that the accumulation of proanthocyanidins is associated with the resistance of plants against a broad spectrum of abiotic and biotic stress conditions. The biosynthesis of proanthocyanidins has been examined extensively, allowing for identifying and characterizing the key regulators controlling the biosynthetic pathway in many plants. New findings revealed that these specific regulators were involved in the proanthocyanidins biosynthetic network in response to various environmental conditions. This paper reviews the current knowledge regarding the control of key regulators in the underlying proanthocyanidins biosynthetic and molecular mechanisms in response to environmental stress. Furthermore, it discusses the directions for future research on the metabolic engineering of proanthocyanidins production to improve food and fruit crop quality.
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8

Attia, Sabry M., Saleh A. Bakheet, and Nouf M. Al-Rasheed. "Proanthocyanidins Produce Significant Attenuation of Doxorubicin-Induced Mutagenicity via Suppression of Oxidative Stress." Oxidative Medicine and Cellular Longevity 3, no. 6 (2010): 404–13. http://dx.doi.org/10.4161/oxim.3.6.14418.

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Анотація:
This study has been initiated to determine whether proanthocyanidins can protect against doxorubicin-induced mutagenicity in mice and to elucidate the potential mechanism of this protection. Pretreatment of mice with proanthocyanidins (100 mg/kg/day, orally) for 7 days and simultaneously with doxorubicin (12 mg/kg, i.p.) for another day, significantly reduced the frequency of bone marrow DNA strand breaks and micronucleated polychromatic erythrocytes compared to doxorubicin-treated mice alone. Furthermore, proanthocyanidins caused a reduction in bone marrow suppression induced by doxorubicin treatment. In male germline, orally administration of proanthocyanidins (100 mg/kg/day, orally) for 7 consecutive days before and 7 consecutive days after treatment with doxorubicin (12 mg/ kg, i.p.), significantly elevated the levels of sperm count and motility reduced by doxorubicin treatment. Furthermore, proanthocyanidins significantly decreased the elevated levels of spermatogonial and spermatocyte chromosomal aberrations and sperm head abnormality induced by doxorubicin. Prior administration of proanthocyanidins ahead of doxorubicin reduced the doxorubicin induced testicular lipid peroxidation and prevented the reduction in testicularnonprotein sulfhydryl significantly. Conclusively, this study provides for the first time that proanthocyanidins have a protective role in the abatement of doxorubicin-induced mutagenesis and cell proliferation changes in germinal cells of mice that reside, at least in part, in their radical scavengeractivity. Therefore, proanthocyanidins can be a promising chemopreventive agent to avert secondary malignancy and abnormal reproductive outcomes risks in cancer patients receiving doxorubicin-involved treatment.
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9

Li, Xin, Jingling Liu, Qinxiang Chang, Ziyun Zhou, Ruilian Han, and Zongsuo Liang. "Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys." Molecules 26, no. 9 (April 21, 2021): 2417. http://dx.doi.org/10.3390/molecules26092417.

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Анотація:
Proanthocyanidins are natural glycosidase inhibitors with excellent antioxidant activity. This study aims to search for a new source of proanthocyanidins for the prevention and treatment of type 2 diabetes with higher content and better activity and get their structure elucidated. First, the total proanthocyanidins contents (TOPCs), antioxidant activity, antidiabetic activity of seven common Polygonaceae plants were analyzed and compared. Then proanthocyanidins from the rhizome of Fagopyrum dibotrys were purified, and the detailed structure was comprehensively analyzed by ultraviolet visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), 13C nuclear magnetic resonance spectroscopy (13C NMR), reversed-phase high-performance liquid chromatography-electrospray mass spectrometry (RP-HPLC-ESI-MS), and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). The rhizome of F. dibotrys showed the highest TOPCs, the strongest antioxidant, and antidiabetic activities; the TOPCs, antioxidant and antidiabetic activities were all very significantly positively correlated. Proanthocyanidins purified from the rhizome of F. dibotrys showed better antidiabetic activity than grape seed proanthocyanidins (GsPs). Seventy-two proanthocyanidins from trimer to undecamer with a mean degree of polymerization (mDP) of about 5.02 ± 0.21 were identified with catechin and epicatechin as the dominant monomers. Conclusion: Proanthocyanidins are the main antioxidant and antidiabetic active substances of F. dibotrys and are expected to be developed into potential antioxidant and hypoglycemic products.
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Tang, Chenyu, Bing Tan, and Xiangjun Sun. "Elucidation of Interaction between Whey Proteins and Proanthocyanidins and Its Protective Effects on Proanthocyanidins during In-Vitro Digestion and Storage." Molecules 26, no. 18 (September 8, 2021): 5468. http://dx.doi.org/10.3390/molecules26185468.

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Анотація:
Whey proteins and oligomeric proanthocyanidins have nutritional value and are widely used in combination as food supplements. However, the effect of the interactions between proanthocyanidins and whey proteins on their stability has not been studied in depth. In this work, we aimed to characterize the interactions between β-Lactoglobulin (β-LG) and α-lactalbumin (α-LA) and oligomeric proanthocyanidins, including A1, A2, B1, B2, B3, and C1, using multi-spectroscopic and molecular docking methods. Fluorescence spectroscopic data revealed that all of the oligomeric proanthocyanidins quenched the intrinsic fluorescence of β-LG or α-LA by binding-related fluorescence quenching. Among the six oligomeric proanthocyanidins, A1 showed the strongest affinity for β-LG (Ka = 2.951 (±0.447) × 104 L∙mol−1) and α-LA (Ka = 1.472 (±0.236) × 105 L∙mol−1) at 297 K. β-LG/α-LA and proanthocyanidins can spontaneously form complexes, which are mainly induced by hydrophobic interactions, hydrogen bonds, and van der Waals forces. Fourier-transform infrared spectroscopy (FTIR) and circular dichroism spectroscopy showed that the secondary structures of the proteins were rearranged after binding to oligomeric proanthocyanidins. During in vitro gastrointestinal digestion, the recovery rate of A1 and A2 increased with the addition of WPI by 11.90% and 38.43%, respectively. The addition of WPI (molar ratio of 1:1) increased the retention rate of proanthocyanidins A1, A2, B1, B2, B3, and C1 during storage at room temperature by 14.01%, 23.14%, 30.09%, 62.67%, 47.92%, and 60.56%, respectively. These results are helpful for the promotion of protein–proanthocyanidin complexes as functional food ingredients in the food industry.
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Більше джерел

Дисертації з теми "Proanthocyanidols"

1

Keunebroek, Jean-Philippe. "Les proanthocyanidols du pin maritime et du cyprès." Paris 5, 1991. http://www.theses.fr/1991PA05P006.

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2

Dumont, Delphine. "Les proanthocyanidols de la vigne : intérêt pharmacologique et applications thérapeutiques." Paris 5, 1992. http://www.theses.fr/1992PA05P031.

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3

Altıok, Evren Ülkü Semra. "Production of proanthocyanidins from grape seed/." [s.l.]: [s.n.], 2003. http://library.iyte.edu.tr/tezler/master/biyoteknoloji/T000247.rar.

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4

Ribas, Latre Aleix. "Modulation of central and peripheral molecular clocks by proanthocyanidins." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/284444.

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Анотація:
Els ritmes circadians permeten als organismes anticipar-se als canvis mediambientals i adaptar el metabolisme al patró d’alimentació i la disponibilitat d’aliments. De fet, les alteracions del ritme circadià provoquen trastorns del metabolisme com la síndrome metabòlica. Els ritmes circadians es mantenen pel rellotge central que es troba a l’ hipotàlem, tot i que els teixits perifèrics també presenten oscil•ladors circadians . Des d’un punt de vista molecular, el sistema circadià està constituït per gens rellotge que interacciones entre si, formant un cicle de regulació. La senyal més important per sincronizar aquest cicle amb l’exterior, és la llum. No obstant, hi ha altres senyals externes, com els cicle d’alimentació-dejuni i alguns components dels aliments, que també poden actuar sincronitzant el rellotge molecular. Les proantocianidines, que són una subclasse de flavonoides, indueixen una amplia gama d’efectes beneficiosos per la salut, millorant totes les patologies de la síndrome metabòlica. Per lo tant, l’objectiu principal d’aquesta tesi va ser avaluar la capacitat de les proantocianidines per modular el rellotge molecular a nivell central i perifèric, sota condicions estàndard o alterades. Els resultats demostren que les proantocianidines modulen els ritmes de expressió dels gens rellotge al llarg de les 24 hores, tant a nivell central con perifèric, tot i que els seus efectes depenen de si el tractament amb proantocianidines ha set durant la fase de llum o la fase de foscor. A més, els efectes sobre el sistema estan associats a canvis de la fluctuació ciracadiana d’alguns metabòlits importants en plasma, o dels nivells de NAD en el fetge. En conjunt, aquests resultats suggereixen que les proantocianidines podrien promoure els seus efectes beneficiosos sobre el metabolisme a través de la seva interacció amb el sistema circadià.
Circadian rhythms allow organisms to anticipate environmental changes and to adapt the metabolism to feeding regime and food availability. In fact, alterations of circadian rhythm induce metabolic disturbances, such as metabolic syndrome. Circadian rhythms are maintained by a central clock in the hypothalamus, but circadian clocks are also present in peripheral tissues. At molecular level, the clock system is composed by feedback loops of core-clock and clock-controlled genes. The most important synchronizer of the clock system is light, but other external cues, such as fasting-feeding time or food components, also act as synchronizers. Proanthocyanidins, a flavonoid sub-class, are reported to have a vast range of beneficial effects improving all the components of the metabolic syndrome. Therefore, the main objective of this thesis was to evaluate the capacity of proanthocyanidins to modulate the central and peripheral molecular clocks under standard or disrupted conditions. Results show that proanthocyanidins modulate the 24-h rhythm expression of clock-core and clock-controlled gens in the central and peripheral clocks. However, the time of proanthocyanidin administration, in the light or dark phase, determine the precise effect on the molecular clock. The modulation of the clock system is associated with variations of the circadian fluctuation of some important metabolites in plasma or NAD levels in liver. Overall these results suggest that proanthocyanidins could mediate their beneficial metabolic effects through their interaction with the clock machinery.
Los ritmos circadianos permiten a los organismos anticiparse a los cambios medioambientales y adaptar el metabolismo al patrón de alimentación y la disponibilidad de alimentos. De hecho, alteraciones del ritmo circadiano provocan trastornos del metabolismo como el síndrome metabólico. Los ritmos circadianos se mantienen por la acción del reloj central ubicado en el hipotálamo, aunque la mayoría de tejidos periféricos también disponen de reloj molecular. Desde un punto de vista molecular, el sistema circadiano está compuesto por genes “reloj” que interaccionan entre sí, formando un bucle de regulación. La señal externa más importante que sincroniza el sistema circadiano con el exterior es la luz, pero los ciclos de alimentación y ayunas, así como algunos componentes de los alimentos también actúan como señales externas sincronizadoras del reloj molecular. Las proantocianidinas, que son una subclase de los flavanoides, ejercen una amplia gama de efectos beneficiosos sobre la salud, mejorando todas las patologías del síndrome metabólico. Por lo tanto, el objetivo de la presente tesis fue evaluar la capacidad de las proantocianidinas para modular el reloj molecular a nivel central y periférico, bajo situaciones estándar o alteradas. Los resultados muestran que las proantocianidinas modulan el ritmo de expresión de los genes reloj a lo largo de las 24 horas, tanto a nivel central como periférico, aunque sus efectos dependen de si el tratamiento con proantocianidinas se ha realizado durante la fase de luz o la fase de oscuridad. Además, los efectos sobre el sistema circadiano están asociados a modificaciones en la fluctuación circadiana de algunos metabolitos importantes en plasma, o de los niveles de NAD en el hígado. En conjunto, estos resultados sugieren que las proantocianidinas podrían mediar sus efectos beneficiosos sobre el metabolismo a través de su interacción con el reloj molecular.
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5

Eydelnant, Irwin Adam. "Inhibition of bacterial adhesion to biomaterials by cranberry derived proanthocyanidins." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112567.

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Анотація:
Nosocomial, or hospital acquired, infections, are ubiquitous within the modern clinical setting leading to over $5 billion annually of related healthcare costs in North America. All indwelling devices are highly susceptible to bacterial colonization where physico-chemical interactions between bacteria and biomaterial surfaces have been implicated as determinant factors in the fate of the initial adhesion processes. It has been proposed that by exploiting interference strategies within this critical step of infection the ability to create 'non-infective' biomaterials may be developed.
This thesis demonstrates the effectivity of North American cranberry (Vaccinium macrocarpon) derived proanthocyanidins in preventing the adhesion of pathogenic bacteria to biomaterial surfaces. Specifically, using a model of catheter associated urinary tract infection, significant reductions in initial adhesion of uropathogenic Escherichia coli and Enterococcus faecalis to PVC and PTFE were observed. With the application of colloidal theory, a mechanism of steric interference was determined as responsible for these effects.
The evidence presented implicates PAC as a molecule of interest for the development of novel biomaterials with increased resistance to bacteria colonization.
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6

Zeng, Hainian. "FOLIAR ANTHOCYANINS AND PROANTHOCYANIDINS IN SIX ORNAMENTAL VARIETIES OF ACER PALMATUM." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-11062009-103243/.

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Анотація:
Anthocyanins are one of the richest pigments, which belong to flavonoid compounds in plant kingdom. They have many biological and ecological functions. Over the past many years, numerous efforts have been made to determine the biosynthetic pathway of anthocyanins and also to identify several regulatory proteins mainly in flowers and fruits of model plants and crop plants. However, many questions concerning the metabolism of anthocyanins in foliage remains unsolved. One example is âHow can developmental processes impact on accumulation patterns of anthocyanins in leavesâ. In this study, we choose several cultivars from one of the most popular ornamental plants Acer palmatum Thunb. to understand the mechanism of developmental changes of pigmentation in leaf. Several other maple species were also analyzed. We propose that the metabolism of anthocyanins play an essential role in such changes. We use an integrated approach of phytochemistry and metabolic profiling to determine the biosynthesis and metabolism of anthocyanins and their impacts on foliage color. Proanthocyanidin analysis was carried out as well to determine their relationship to both anthocyanin production and foliar coloration. We have found that even for green leaves with no/trace amount of detectable anthocyanins, the biosynthetic pathway of anthocyanidin/proanthocyanidin is still activated. Our results indicate that metabolic channeling directing the anthocyanin pathway to the proanthocyanidin biosynthesis plays a very important role in pigmentation pattern change along developmental processes.
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7

Weckman, Nicole. "Quartz crystal microbalance studies of biomolecule binding to cranberry derived proanthocyanidins." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121484.

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Анотація:
While cranberry consumption has been linked with the prevention of bacterial infections in the urinary tract for many years, our understanding of the bioavailability and mechanisms by which cranberry prevents bacterial infection is limited. Despite frequent use in clinical trials, it is hypothesized that the bioavailability of cranberry derived materials in the urinary tract may be limited due to their interaction with human serum proteins such as albumin, α-1-acid glycoprotein (AAG), and fibrinogen. Upon reaching the urinary tract, cranberry derived materials may interfere with bacterial pathogenesis via interaction with the lipopolysaccharides (LPS) on the bacterial cell surface and the secreted biosurfactant, rhamnolipid. Quartz crystal microbalance with dissipation monitoring (QCM-D) is a sensitive mass sensor that is used in this study to directly investigate the interactions between cranberry derived materials and human serum proteins (albumin, AAG, and fibrinogen) or bacterial components (LPS and rhamnolipid). The binding of cranberry proanthocyanidins (CPAC) to all three serum proteins, the rhamnolipids, and LPS from the uropathogen Escherichia coli O111:B4 can be described by Langmuir-type isotherms allowing the determination of the apparent adsorption affinity constant between the CPAC and each biomolecule. CPAC interacts most strongly with fibrinogen with a binding constant of 2.2×108 M-1. CPAC exhibits weaker interactions with albumin and AAG, with binding constants of 2.4×106 M-1 and 1.5×106 M-1, respectively. These binding interactions will limit the bioavailability of the CPAC at the site of action thus highlighting the need for an improved understanding of the bioavailability and pharmacokinetics of cranberry consumption before further clinical trials. Furthermore, CPAC interacts with LPS from Pseudomonas aeruginosa 10 in a fundamentally different manner than it interacts with E. coli O111:B4 LPS or P. aeruginosa rhamnolipids, supporting the theory that there are multiple mechanisms via which cranberry prevents bacterial infections and that cranberry may be more effective at preventing certain bacterial infections.
Tandis que la consommation de canneberge a été liée à la prévention d'infections bactériennes dans les voies urinaires pendant de nombreuses années, notre compréhension de la biodisponibilité et les mécanismes par lequel canneberge empêche les infections bactériennes est limitée. Malgré l'utilisation fréquente dans les essais cliniques, la biodisponibilité de matières dérivées de canneberges dans les voies urinaires peut être limitée en raison de leur interaction avec les protéines de sérum humain tels que l'albumine, α-1 glycoprotéine acide (AAG) et du fibrinogène. Dès qu'elles arrivent à la voie urinaire, les matières dérivées de canneberges peuvent interférer avec la pathogenèse bactérienne via l'interaction avec les lipopolysaccharides (LPS) sur la surface bactérienne et les biosurfactants sécrétées, rhamnolipide. Microbalance à quartz avec la surveillance de la dissipation (QCM-D) est un instrument capable de détecter de mass avec une haute sensibilité qui est utilisé dans cette étude d'enquêter directement sur les interactions entre les matières dérivées de canneberges et protéines de sérum humain ou des composants bactériens (LPS et rhamnolipide). Les liaisons entre les proanthocyanidines de canneberge (CPAC) et les trois protéines sériques, les rhamnolipides, et le LPS de Escherichia coli O111:B4 uropathogènique peut être décrite par les isothermes de type Langmuir permettant la détermination de la constante d'affinité apparente d'adsorption entre la CPAC et chaque biomolécule. CPAC interagit fortement avec le fibrinogène avec une constante de fixation de 2.2x108 M-1. CPAC a des interactions plus faibles avec l'albumine et AAG, avec les constantes de fixation de 2.4x106 M-1 et 1.5x106 M-1, respectivement. Ces interactions de liaison limiteront la biodisponibilité de la CPAC au site d'action, mettant ainsi en évidence la nécessité d'une meilleure compréhension de la biodisponibilité et la pharmacocinétique de la consommation de canneberge avant d'autres essais cliniques. De plus, CPAC interagit avec le LPS de Pseudomonas aeruginosa 10 de manière fondamentalement différente qu'il interagit avec le LPS de E. coli O111:B4 ou rhamnolipides de P. aeruginosa, soutenant la théorie selon laquelle il y a plusieurs mécanismes par laquelle canneberge empêche les infections bactériennes et la canneberge peut-être plus efficace pour prévenir certaines infections bactériennes.
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8

Quesada, Isabel Maria. "Effects of dietary catechins and proanthocyanidins on zinc homeostasis in hepatic cells." Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/8695.

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Анотація:
Les catequines i els seus polímers, les procianidines, són flavonoids presents en hortalisses
i fruits amb efectes beneficiosos sobre la salut. Actuen com a antioxidants segrestant
espècies reactives d'oxigen (ROS) i quelant els metalls ferro i coure. També es comporten
com a molècules senyalitzadores, modulant múltiples vies de senyalització i metabòliques i
l'expressió gènica, incloent-hi la d'enzims antioxidants. Resultats previs del Grup de Recerca
en Nutrigenòmica mostren que una dosi oral aguda d'un extracte de procianidines de llavor
de raïm (GSPE) reprimeix l'expressió de les metal·lotioneïnes (MT), proteïnes lligadores de
zinc, a fetge de rates, i tanmateix incrementa l'expressió del receptor nuclear orfe small
heterodimer partner.(SHP/Nr0b2) (Del Bas et al., 2005). Igualment, es va demonstrar que les
procianidines actuen com a coactivadors transcripcionals del receptor nuclear d'àcids biliars
Farnesoid X Receptor (FXR), el qual es responsable de la sobre-expressió de SHP causada
per GSPE a cèl·lules hepàtiques, i de l'efecte hipotrigliceridèmic de les prociandines effect
(Del Bas et al., 2008; Del Bas et al., 2009).
Els objectius d'aquesta Tesi van ser determinar si les catequines i procianidines
interaccionen amb el zinc, avaluar el seu efecte sobre l'homeòstasi del zinc en cèl·lules
hepàtiques -incloent l'efecte sobre l'expressió de genes MT, utilitzats aquí com a
biomarcadors de l'activitat de les procianidines a cèl·lules hepàtiques-, i disseccionar els
mecanismes pels quals les procianidines afecten l'homeòstasi del zinc, en particular
confirmar si els gens MT són dianes de SHP i FXR.
Els resultats obtinguts mostren que GSPE, així com diverses catequines i procianidines
pures, incloent-hi el flavonoid del te verd (-)-epigallocatechin-3-gallate (EGCG), lliguen
cations de zinc en solució amb una afinitat més gran que el quelant específic de zinc
Zinquin. En cèl·lules d'hepatocarcinoma humanes HepG2, GSPE inhibeix l'acumulació
intracel·lular de zinc i contraresta els efectes tòxics de dosis elevades de zinc sobre la
viabilitat cel·lular. GSPE reprimeix l'expressió de gens de MTs i d'exportadors de zinc mentre
que estimula l'expressió d'importadors de zinc. L'expressió dels importadors de zinc de la
xarxa Trans-Golgi és estimulada per GSPE. A més a més, GSPE bloqueja la inducció de
l'expressió de MTs per la citoquina proinflamatoria IL-6, pel generador de ROS tBOOH, per
l'agonista de receptors de glucocorticoids dexametasona, i pels metalls coure i zinc.
EGCG reprodueix els efectes de GSPE sobre l'homeòstasi del zinc en HepG2, reprimint
l'expressió de MTs i d'exportadors de zinc, estimulant l'expressió d'importadors de zinc, i
UNIVERSITAT ROVIRA I VIRGILI
EFFECTS OF DIETARY CATECHINS AND PROANTHOCYANIDINS ON ZINC HOMEOSTASIS IN HEPATIC CELLS
Isabel Maria Quesada
ISBN:978-84-694-1258-9/DL:T-322-2011
inhibint l'acumulació de zinc intracel·lular i la toxicitat de dosis elevades de zinc. La
procinidina dimèrica B1 i la trimèrica C1 es comporten tenen efectes contraris als de GSPE i
EGCG pel que fa a l'expressió de MT i l'acumulació de zinc total en cèl·lules HepG2.
Pel que fa al zinc làbil citoplasmàtic, la minúscula fracció del total del zinc cel·lular que
modula múltiples vies metabòliques i senyalitzadores, tant GSPE com EGCG i C1 eleven en
gran manera els nivells de zinc làbil detectable per Zinquin a cèl·lules HepG2.
Experiments amb ratolins KO per SHP o per FXR han demonstrat que GSPE reprimeix
l'expressió postprandrial de gens MT a fetge per una via que no depen de SHP però que és
depenent de FXR. A més, l'àcid biliar CDCA, un lligand fisiològic i activador de FXR,
reprimeix l'expressió de gens MT a cèl·lules HepG2. Per tant, els gens MT són diana de FXR
i, conseqüentment, FXR apareix com un receptor nuclear que modula l'homeòstasi del zinc.
Per explicar aquests resultats, proposem que catequines i procianidines poden actuar tant
com a segrestadors de zinc -evitant la seva entrada a la cèl·lula a través dels transportadors
de zinc de membrana plasmàtica-, com d'ionòfors de zinc -cotransportant cations zinc a
través de la bicapa lipídica i incrementant així els nivells de zinc làbil citoplasmàtic. La
repressió de gens MT induïda per l'activació de FXR per GSPE podria també contribuir a
l'increment de zinc làbil, en impedir que els cations zinc siguin segrestats per apo-tioneïna
sintetitzada de novo.
Donat el paper del zinc làbil com a modulador de múltiples víes de senyalització i
metabòlics, formulem la hipòtesi que la quelació extracel·lular de cations de zinc i l'elevació
de zinc làbil citoplasmàtic són mecanismes subjacents a l'activitat biològica de catequines i
procianidines i, per tant, que les vies metabòliques i de senyalització afectades pel zinc làbil,
ho seràn també per aquests flavonoids.
Effects of dietary catechins and proanthocyanidins on zinc homeostasis in
hepatic cells.
Catechins and their polymers procyanidins are health-promoting flavonoids found in edible
vegetables and fruits. They act as antioxidants by scavenging reactive oxygen species and
by chelating the redox-active metals iron and copper. They also behave as signaling
molecules, modulating multiple cell signaling and metabolic pathways and gene expression,
including that of antioxidant enzymes. Previous results of the Nutrigenomics Reseach Group
showed that an oral acute dose of a grape-seed procyanidin extract (GSPE) represses the
expression of the zinc-binding protein metallothionein (MT) genes in rat liver, and enhances
the expression of the orfan nuclear receptor small heterodimer partner (SHP/Nr0b2) (Del Bas
et al., 2005). In addition, it was shown that procyanidins act as transcriptional coactivators of
the nuclear bile acid receptor Farnesoid X Receptor (FXR), which in turns upregulates SHP
expression, thereby exerting an hypotrygliceridemic effect (Del Bas et al., 2008; Del Bas et
al., 2009).
The objectives of this Ph.D. Thesis were to determine whether catechins and procyanidins
interact with the redox-inactive metal zinc, to evaluate their effect on zinc homeostasis in
hepatic cells -including the expression of MT genes, used here as a biomarkers of
procyanidin activity in hepatic cells-, and to disect the mechanisms by which procyanidins
affect cellular zinc homeostasis, in particular to asses whether MT genes are targets of SHP
and FXR.
Our results show that GSPE, as well as individual catechins and procyanidins tested,
including the green tea flavonoid (-)-epigallocatechin-3-gallate (EGCG), bind zinc cations in
solution with higher affinity than the zinc-specific chelator Zinquin. In human
hepatocarcinoma HepG2 cells, GSPE inhibits intracellular zinc accumulation and counteracts
the toxic effects of excess zinc on cell viability. At the mRNA expression level, GSPE
downregulates MTs and zinc-efflux transporters while upregulating zinc-influx transporters.
Zinc importers of the Trans-Golgi network are upregulated by GSPE. In addition, GSPE
blocks the induction of MTs expression by the proinflammatory cytokine IL-6, the ROS
generator tBOOH, the glucocorticoid receptor agonist dexamethasone, and the metals
copper and zinc.
EGCG reproduces the major effects of GSPE on zinc homeostasis in HepG2, downreguling
the expression of MTs and zinc-efflux transporters, while upregulating the expression of zincinflux
transporters, concomitantly inhibiting intracellular zinc accumulation and the toxicity of high zinc doses. Procyanidin dimer B1 and trimer C1 behave opposite to GSPE and EGCG
with regard to MT expression and intracellular zinc accumulation in HepG2 cells.
Concerning cytoplasmic labile zinc, the tiny fraction of total cellular zinc that modulates
signaling and metabolic pathways, we found that GSPE, EGCG and trimeric procyanidin C1
greatly elevate Zinquin-detectable labile zinc in HepG2 cells.
Experiments with SHP-null and FXR-null mice demonstrate that GSPE downregulates
postprandial expression of MT genes in the liver, in a SHP-independent but FXR-dependent
manner. In addition, chenodeoxycholic acid, a physiological ligand and activator of FXR,
represses the expression of MT genes in HepG2 cells. Thus, MT genes are targets of FXR
and, consequently, FXR is revealed as a modulator of zinc homeostasis.
To explain these results, we postulate that catechins and procyanidis may act both as
sequestrants of zinc -thereby impeding the entrance of zinc cations to the cell through
plasma membrane zinc transporters-, and as zinc ionophores -thereby cotransporting zinc
cations through the lipid bilayer and increasing the levels of cytoplasmic labile zinc.
Repression of MT expression by procyanidin-activated FXR might also contribute to the
increment of the labile pool of zinc, by hindering the sequestration of zinc-cations by de novo
synthesized apo-thionein.
Given the role of labile zinc as modulator of multiple intracellular signaling and metabolic
pathways, we forward the hypothesis that extracellular complexation of zinc cations and
subsequent elevation of cytoplasmic labile zinc may be relevant mechanisms underlying the
health-promoting activity of catechins and procyanidins and, therefore, that the signaling and
metabolic pathways modulated by labile zinc will be aslo a target of these flavonoids.
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9

González, Quilen Carlos Alberto. "Impact of Proanthocyanidins on Intestinal Dysfunction Induced by Nutritional or Chemical Agents." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/669807.

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Анотація:
El tracte intestinal és un lloc d'interacció amb microorganismes i factors ambientals potencialment nocius. En aquest sentit, un alt consum de components majoritaris de la dieta occidental com la fructosa i els greixos saturats s'ha associat amb la disfunció intestinal (disrupció de la funció de barrera i inflamació) i l'entrada d'endotoxines bacterianes amb efecte proinflamatori en la circulació. Addicionalment, una alta concentració d'endotoxina en plasma (endotoxemia metabòlica) es vincula amb la síndrome metabòlica. Així, l'intestí està emergint com un blanc terapèutic per a la prevenció i tractament de malalties. Les proantocianidines (PACs) són compostos fenòlics naturals amb potent efecte antiinflamatori en la mucosa intestinal d'acord amb evidència preclínica. Per tant, l'administració de PACs és prometedora com a estratègia terapèutica complementària, però la seva eficàcia s'ha de confirmar en humans. El principal objectiu de la present tesi doctoral va ser avaluar l'impacte d'un extracte de PACs de la pinyol de raïm (GSPE) en models preclínics de disfunció intestinal i explorar la seva efectivitat en l'humà. Trobem que una dieta estil occidental (dieta de cafeteria) indueix disfunció intestinal en rates i que l'alteració de permeabilitat al còlon contribueix en gran mesura a la endotoxemia metabòlica. Aquests efectes van ser atribuïts parcialment a altes concentracions luminals de fructosa i van poder ser revertits amb dosis farmacològiques de GSPE in vivo. Finalment, contrastem aquests resultats amb evidència derivada d'un model humà ex vivo de disfunció colònica. En aquest model vam poder replicar la reducció de permeabilitat i la millora de l'estat inflamatori reportats in vivo. En conclusió, l'administració de GSPE pot millorar la disfunció intestinal i la endotoxemia metabòlica associada. Les dosis efectives en humans són probablement farmacològiques i hauran de ser establertes en estudis clínics posteriors.
El tracto intestinal es un sitio de interacción con microorganismos y factores ambientales potencialmente dañinos. En este sentido, un alto consumo de componentes mayoritarios de la dieta occidental como la fructosa y las grasas saturadas se ha asociado con la disfunción intestinal (disrupción de la función de barrera e inflamación) y la entrada de endotoxinas bacterianas con efecto proinflamatorio en la circulación. Adicionalmente, una alta concentración de endotoxina en plasma (endotoxemia metabólica) se vincula con el síndrome metabólico. Así, el intestino está emergiendo como un blanco terapéutico para la prevención y tratamiento de enfermedades. Las proantocianidinas (PACs) son compuestos fenólicos naturales con potente efecto antiinflamatorio en la mucosa intestinal, de acuerdo con evidencia preclínica. Por consiguiente, la administración de PACs es prometedora como estrategia terapéutica complementaria, pero su eficacia debe ser confirmada en humanos. El principal objetivo de la presente tesis doctoral fue evaluar el impacto de un extracto de PACs de la pepita de uva (GSPE) en modelos preclínicos de disfunción intestinal y explorar su efectividad en el humano. Encontramos que una dieta estilo occidental (dieta de cafetería) induce disfunción intestinal en ratas y que la alteración de permeabilidad en el colon contribuye en gran medida a la endotoxemia metabólica. Estos efectos fueron atribuidos parcialmente a altas concentraciones luminales de fructosa y pudieron ser revertidos con dosis farmacológicas de GSPE in vivo. Por último, contrastamos estos resultados con evidencia derivada de un modelo humano ex vivo de disfunción colónica. En este modelo pudimos replicar la reducción de permeabilidad y el mejoramiento del estado inflamatorio reportados in vivo. En conclusión, la administración de GSPE puede mejorar la disfunción intestinal y la endotoxemia metabólica asociada. Las dosis efectivas en humanos son probablemente farmacológicas y tendrán que ser establecidas en estudios clínicos posteriores.
The intestinal tract is a site of interaction with microorganisms and potentially detrimental environmental factors. The high intake of fructose and saturated fats typical of the Western diet has been associated with intestinal dysfunction (disruption of barrier function and inflammation) and an increased influx of proinflammatory bacterial endotoxins into the systemic circulation. In turn, high concentrations of plasma endotoxins (metabolic endotoxemia) are a precursor to the onset of metabolic syndrome. In view of the above, the intestine is emerging as a target for disease prevention and therapy. Proanthocyanins (PACs) are naturally occurring phenolic compounds with remarkable anti-inflammatory properties in the intestinal mucosa, according to preclinical studies. Thus, PAC administration is a promising adjunctive therapeutic strategy for the treatment of intestinal dysfunction, but its efficacy in humans is yet to be confirmed. The main objective of this doctoral thesis was to evaluate the impact of a grape-seed PAC extract (GSPE) on a rat and cell culture-based model of intestinal dysfunction and to investigate its effectiveness in humans. We found that a long-term Western-style diet (cafeteria diet) induces intestinal dysfunction in rats, and that alterations in the permeability of the colon largely contribute to metabolic endotoxemia. These effects are partially driven by high luminal concentrations of fructose and could be effectively reversed in vivo by pharmacological doses of GSPE. Lastly, we compared these findings with evidence derived from an ex vivo human model of chemically-induced colonic dysfunction in which we were able to replicate the reduction of intestinal permeability and the amelioration of inflammatory status by means of GSPE found in vivo. In conclusion, the administration of GSPE results in the overall improvement of intestinal dysfunction and associated metabolic endotoxemia. Effective doses in humans are probably pharmacological and will have to be determined in clinical trials.
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10

Stringano, Elisabetta. "Analysis of sainfoin (Onobrychis viciifolia) proanthocyanidins by complementary and newly developed techniques." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553034.

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Sainfoin proanthocyanidins (PAs) are complex mixtures of homo- and hetero- polymers consisting of B-type procyanidins and prodelphinidins. Direct analysis by thiolytic degradation revealed a wide range of PA contents and compositions within the HealthyHay germplasm collection (46 accessions). PA contents varied from 0.57% to 2.80% (g PAl100g freeze-dried samples). PAs polymer size ranged from 12 to 84 flavan-3-ol units in terms of their mean degree of polymerisation. Prodelphinidin/procyanidin ratios ranged from 53/47 to 95/5 and trans/cis ratios varied from 12/88 to 34/66. Purified PAs fractions from 4 selected accessions showed a positive correlation between polymer size and prodelphinidin content within each accession (R2 from 0.69 to 0.92). Careful selection of MALDI-TOF MS matrices and analytical conditions made it possible to detect PAs up to 12 subunits and also ion signals that could be assigned to A-type and rarely reported glycosylated A-type PAs. For detecting and confirming the polymer size of underivatised higher molecular weight PAs a new HPLC-GPC technique consisting in a single calibration curve for galloyl glucoses, ellagitannins and PAs was developed. Peak-average molecular weights of sainfoin PA fractions were overestimated by 42.0% at 2436 Dalton and underestimated by 13.9% at 8318 Dalton. Number-average molecular weights were overestimated by 30.0% and underestimated by 25.8%, respectively. Cluster analysis of the HealthyHay germplasm collection revealed that accessions clustered into two main clusters, Western Europe and Eastern Europe/Asia, and that accessions from Armenia, Canada and USA clustered into another group. This seems to be in agreement with the strong links between geographic origin and accession performance found in the HealthyHay sainfoin germplasm. This research made significant contributions to the fields of PA analysis and germplasm screening in terms of novel analytical techniques for determining the average molecular weight distribution, content, subunit composition and linkages, purification and fractionation of proanthocyanidins in sainfoin.
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Книги з теми "Proanthocyanidols"

1

Goldman, Bob. OPCs (Oligomeric Proanthocyanidins): Harvesting nature's anti-aging bounty. [United States?]: R. Goldman, 2002.

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2

Schwitters, Bert. OPC in Practice: The Hidden Story of Proanthocyanidins. Alfa Omega Editrice, 1993.

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3

Sullivan, Ingrid. Proanthocyanidins: Food Sources, Antioxidant Properties and Health Benefits. Nova Science Publishers, Incorporated, 2015.

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Частини книг з теми "Proanthocyanidols"

1

Ebrahimnejad, Hadi, Torsten Burkholz, and Claus Jacob. "Flavanols and Proanthocyanidins." In Recent Advances in Redox Active Plant and Microbial Products, 211–32. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8953-0_8.

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2

Porter, Lawrence J. "Flavans and proanthocyanidins." In The Flavonoids, 23–55. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-2911-2_2.

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3

Porter, Lawrence J. "Flavans and proanthocyanidins." In The Flavonoids, 21–62. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-2913-6_2.

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4

Karchesy, Joseph J., Youngsoo Bae, Linda Chalker-Scott, Richard F. Helm, and L. Yeap Foo. "Chromatography of Proanthocyanidins." In Chemistry and Significance of Condensed Tannins, 139–51. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-7511-1_9.

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5

Steynberg, Jan P., E. Vincent Brandt, Matthiam J. H. Hoffman, Richard W. Hemingway, and Daneel Ferreira. "Conformations of Proanthocyanidins." In Plant Polyphenols, 501–20. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3476-1_29.

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6

Bladé, Cinta, Anna Arola-Arnal, Anna Crescenti, Manuel Suárez, Francisca I. Bravo, Gerard Aragonès, Begoña Muguerza, and Lluís Arola. "Proanthocyanidins and Epigenetics." In Handbook of Nutrition, Diet, and Epigenetics, 1933–56. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-55530-0_16.

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7

Bladé, Cinta, Anna Arola-Arnal, Anna Crescenti, Manuel Suárez, Francisca I. Bravo, Gerard Aragonès, Begoña Muguerza, and Lluís Arola. "Proanthocyanidins and Epigenetics." In Handbook of Nutrition, Diet, and Epigenetics, 1–24. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-31143-2_16-1.

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8

Hu, Hanbo, and Donald Armstrong. "Isotonic oligomeric proanthocyanidins." In Oxidative Stress and Antioxidant Protection, 403–14. Hoboken, NJ, USA: John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118832431.ch26.

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9

Hemingway, R. W. "Biflavonoids and Proanthocyanidins." In Natural Products of Woody Plants, 571–651. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74075-6_17.

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10

Oliveira, Joana, Nuno Mateus, and Victor de Freitas. "Flavanols: Catechins and Proanthocyanidins." In Natural Products, 1753–801. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_58.

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Тези доповідей конференцій з теми "Proanthocyanidols"

1

Zhang, Yun, Katherine Weh, Connor Howard, Kiran Lagisetty, Dyke McEwen, Jules Lin, Rishindra M. Reddy, et al. "Abstract 1418: Proanthocyanidins enhance chemotherapy-induced esophageal adenocarcinoma cell death." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1418.

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2

Imran, BI, M. Karonen, and JP Salminen. "Modification of oligomeric and polymeric proanthocyanidins via oxidation in alkaline conditions." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399908.

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Chen, Jie, Ruobin Zhang, Liming Wang, and Mengbin Mo. "Effect of pulsed electric fields on proanthocyanidins in young red wine." In 2009 IEEE 9th International Conference on the Properties and Applications of Dielectric Materials (ICPADM). IEEE, 2009. http://dx.doi.org/10.1109/icpadm.2009.5252311.

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Weh, Katherine M., Bridget A. Tripp, Jennifer L. Clarke, Amy B. Howell, Jules Lin, David G. Beer, Andrew C. Chang, and Laura A. Kresty. "Abstract 279: Cranberry proanthocyanidins mitigate reflux-induced transporter dysregulation in esophageal adenocarcinoma." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-279.

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Thilakarathna, Wasitha, and H. P. Vasantha Rupasinghe. "Abstract 314: Highly polymeric grape seed proanthocyanidins: A call for establishing the safe dose." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-314.

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Zeyzus-Johns, Bree, Amy Exum, Amy B. Howell, and Laura A. Kresty. "Abstract B67: In vitro and in vivo inhibitory effects of cranberry proanthocyanidins against esophageal adenocarcinoma." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Nov 7-10, 2010; Philadelphia, PA. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1940-6207.prev-10-b67.

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Toden, Shusuke, and Ajay Goel. "Abstract 4311: Oligomeric proanthocyanidins inhibit Hippo-YAP pathway and prevent colorectal cancer stem cell formation." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4311.

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Symma, N., J. Sendker, F. Petereit, M. Letzel, and A. Hensel. "Transferring petrochemical methods to pharmacognosy: a novel screening system for oligomeric proanthocyanidins using Kendrick mass defect." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399937.

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Bystrom, Laura M., Luis Andres Lara-Martinez, Bernardo Gomel, Burak Isal, Hongliang Zong, Sabrina Martinez, Catherine Neto, Stefano Rivella, and Monica L. Guzman. "Abstract 1232: A-type proanthocyanidins selectively target acute myeloid leukemia cells in vitro and in vivo." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1232.

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Ravindranathan, Preethi, Divya Pasham, Uthra Balaji, Shusuke Toden, and Ajay Goel. "Abstract 2682: Global transcriptomic profiling reveals anticancer role of oligomeric proanthocyanidins from grape seeds in colorectal cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2682.

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Звіти організацій з теми "Proanthocyanidols"

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Delehanty, J. B., B. J. Johnson, T. E. Hickey, T. Pons, and F. S. Ligler. Plant Proanthocyanidins Bind to and Neutralize Bacterial Lipopolysaccharides. Fort Belvoir, VA: Defense Technical Information Center, January 2008. http://dx.doi.org/10.21236/ada517872.

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