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Добірка наукової літератури з теми "PSKH1"

Автор: Grafiati

Опубліковано: 6 січня 2025

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Статті в журналах з теми "PSKH1"

Brede, G. "PSKH1, a novel splice factor compartment-associated serine kinase." Nucleic Acids Research 30, no. 23 (December 1, 2002): 5301–9. http://dx.doi.org/10.1093/nar/gkf648.

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Brede, Gaute, Jorun Solheim, Espen Stang, and Hans Prydz. "Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus." Experimental Cell Research 291, no. 2 (December 10, 2003): 299–312. http://dx.doi.org/10.1016/j.yexcr.2003.07.009.

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Firth, Neville, Sumalee Apisiridej, Tracey Berg, Brendon A. O'Rourke, Steve Curnock, Keith G. H. Dyke, and Ronald A. Skurray. "Replication of Staphylococcal Multiresistance Plasmids." Journal of Bacteriology 182, no. 8 (April 15, 2000): 2170–78. http://dx.doi.org/10.1128/jb.182.8.2170-2178.2000.

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ABSTRACT Based on structural and functional properties, three groups of large staphylococcal multiresistance plasmids have been recognized, viz., the pSK1 family, pSK41-like conjugative plasmids, and β-lactamase–heavy-metal resistance plasmids. Here we describe an analysis of the replication functions of a representative of each of these plasmid groups. The replication initiation genes from theStaphylococcus aureus plasmids pSK1, pSK41, and pI9789::Tn552 were found to be related to each other and to the Staphylococcus xylosus plasmid pSX267 and are also related to rep genes of several plasmids from other gram-positive genera. Nucleotide sequence similarity between pSK1 and pI9789::Tn552 extended beyond theirrep genes, encompassing upstream divergently transcribed genes, orf245 and orf256, respectively. Our analyses revealed that genes encoding proteins related to the deducedorf245 product are variously represented, in several types of organization, on plasmids possessing six seemingly evolutionarily distinct types of replication initiation genes and including both theta-mode and rolling-circle replicons. Construction of minireplicons and subsequent functional analysis demonstrated that orf245is required for the segregational stability of the pSK1 replicon. In contrast, no gene equivalent to orf245 is evident on the conjugative plasmid pSK41, and a minireplicon encoding only the pSK41 rep gene was found to exhibit a segregational stability approaching that of the parent plasmid. Significantly, the results described establish that many of the large multiresistance plasmids that have been identified in clinical staphylococci, which were formerly presumed to be unrelated, actually utilize an evolutionarily related theta-mode replication system.

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Brede, Gaute, Jorun Solheim, Gunhild Tröen, and Hans Prydz. "Characterization of PSKH1, a Novel Human Protein Serine Kinase with Centrosomal, Golgi, and Nuclear Localization." Genomics 70, no. 1 (November 2000): 82–92. http://dx.doi.org/10.1006/geno.2000.6365.

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Dai, Yiping, Liping Xie, Xunhao Xiong, Lei Chen, Weimin Fan, and Rongqing Zhang. "Cloning and Characterization of a Homologous Ca2+/calmodulin-dependent protein kinase PSKH1 from pearl oyster pinctada fucata." Tsinghua Science and Technology 10, no. 4 (August 2005): 504–11. http://dx.doi.org/10.1016/s1007-0214(05)70108-5.

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Fan, Danyang, Yilong Yao, Yanwen Liu, Chao Yan, Fanqinyu Li, Shilong Wang, Mei Yu, Bingkun Xie, and Zhonglin Tang. "Regulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle." Genes 15, no. 3 (February 21, 2024): 269. http://dx.doi.org/10.3390/genes15030269.

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Skeletal muscle plays critical roles in providing a protein source and contributing to meat production. It is well known that microRNAs (miRNAs) exert important effects on various biological processes in muscle, including cell fate determination, muscle fiber morphology, and structure development. However, the role of miRNA in skeletal muscle development remains incompletely understood. In this study, we observed a critical miRNA, miR-24-3p, which exhibited higher expression levels in Tongcheng (obese-type) pigs compared to Landrace (lean-type) pigs. Furthermore, we found that miR-24-3p was highly expressed in the dorsal muscle of pigs and the quadriceps muscle of mice. Functionally, miR-24-3p was found to inhibit proliferation and promote differentiation in muscle cells. Additionally, miR-24-3p was shown to facilitate the conversion of slow muscle fibers to fast muscle fibers and influence the expression of GLUT4, a glucose transporter. Moreover, in a mouse model of skeletal muscle injury, we demonstrated that overexpression of miR-24-3p promoted rapid myogenesis and contributed to skeletal muscle regeneration. Furthermore, miR-24-3p was found to regulate the expression of target genes, including Nek4, Pim1, Nlk, Pskh1, and Mapk14. Collectively, our findings provide evidence that miR-24-3p plays a regulatory role in myogenesis and fiber type conversion. These findings contribute to our understanding of human muscle health and have implications for improving meat production traits in livestock.

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de Souza, João V., Matthew Kondal, Piotr Zaborniak, Ryland Cairns, and Agnieszka K. Bronowska. "Controlling the Heterodimerisation of the Phytosulfokine Receptor 1 (PSKR1) via Island Loop Modulation." International Journal of Molecular Sciences 22, no. 4 (February 11, 2021): 1806. http://dx.doi.org/10.3390/ijms22041806.

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Phytosulfokine (PSK) is a phytohormone responsible for cell-to-cell communication in plants, playing a pivotal role in plant development and growth. The binding of PSK to its cognate receptor, PSKR1, is modulated by the formation of a binding site located between a leucine-rich repeat (LRR) domain of PSKR1 and the loop located in the receptor’s island domain (ID). The atomic resolution structure of the extracellular PSKR1 bound to PSK has been reported, however, the intrinsic dynamics of PSK binding and the architecture of the PSKR1 binding site remain to be understood. In this work, we used atomistic molecular dynamics (MD) simulations and free energy calculations to elucidate how the PSKR1 island domain (ID) loop forms and binds PSK. Moreover, we report a novel “druggable” binding site which could be exploited for the targeted modulation of the PSKR1-PSK binding by small molecules. We expect that our results will open new ways to modulate the PSK signalling cascade via small molecules, which can result in new crop control and agricultural applications.

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Pollet, Rebecca M., James D. Ingle, Jeff P. Hymes, Thomas C. Eakes, Karina Yui Eto, Stephen M. Kwong, Joshua P. Ramsay, Neville Firth, and Matthew R. Redinbo. "Processing of Nonconjugative Resistance Plasmids by Conjugation Nicking Enzyme of Staphylococci." Journal of Bacteriology 198, no. 6 (January 4, 2016): 888–97. http://dx.doi.org/10.1128/jb.00832-15.

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ABSTRACTAntimicrobial resistance inStaphylococcus aureuspresents an increasing threat to human health. This resistance is often encoded on mobile plasmids, such as pSK41; however, the mechanism of transfer of these plasmids is not well understood. In this study, we first examine key protein-DNA interactions formed by the relaxase enzyme, NES, which initiates and terminates the transfer of the multidrug resistance plasmid pSK41. Two loops on the NES protein, hairpin loops 1 and 2, form extensive contacts with the DNA hairpin formed at theoriTregion of pSK41, and here we establish that these contacts are essential for proper DNA cleavage and religation by the full 665-residue NES proteinin vitro. Second, pSK156 and pCA347 are nonconjugativeStaphylococcus aureusplasmids that contain sequences similar to theoriTregion of pSK41 but differ in the sequence predicted to form a DNA hairpin. We show that pSK41-encoded NES is able to bind, cleave, and religate theoriTsequences of these nonconjugative plasmidsin vitro. Although pSK41 could mobilize a coresident plasmid harboring its cognateoriT, it was unable to mobilize plasmids containing the pSK156 and pCA347 variantoriTmimics, suggesting that an accessory protein like that previously shown to confer specificity in the pWBG749 system may also be involved in transmission of plasmids containing a pSK41-likeoriT. These data indicate that the conjugative relaxase intransmechanism recently described for the pWBG749 family of plasmids also applies to the pSK41 family of plasmids, further heightening the potential significance of this mechanism in the horizontal transfer of staphylococcal plasmids.IMPORTANCEUnderstanding the mechanism of antimicrobial resistance transfer in bacteria such asStaphylococcus aureusis an important step toward potentially slowing the spread of antimicrobial-resistant infections. This work establishes protein-DNA interactions essential for the transfer of theStaphylococcus aureusmultiresistance plasmid pSK41 by its relaxase, NES. This enzyme also processed variantoriT-like sequences found on numerous plasmids previously considered nontransmissible, suggesting that in conjunction with an uncharacterized accessory protein, these plasmids may be transferred horizontally via a relaxase intransmechanism. These findings have important implications for our understanding of staphylococcal resistance plasmid evolution.

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Zhu, Wenming, Nancye Clark, and Jean B. Patel. "pSK41-Like Plasmid Is Necessary for Inc18-LikevanAPlasmid Transfer from Enterococcus faecalis to Staphylococcus aureusIn Vitro." Antimicrobial Agents and Chemotherapy 57, no. 1 (October 22, 2012): 212–19. http://dx.doi.org/10.1128/aac.01587-12.

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ABSTRACTVancomycin-resistantStaphylococcus aureus(VRSA) is thought to result from thein vivoconjugative transfer of avanAplasmid from anEnterococcussp. toS. aureus. We studied bacterial isolates from VRSA cases that occurred in the United States to identify microbiological factors which may contribute to this plasmid transfer. First, vancomycin-susceptible, methicillin-resistantS. aureus(MRSA) isolates from five VRSA cases were tested for their ability to accept foreign DNA by conjugation in mating experiments withEnterococcus faecalisJH2-2 containing pAM378, a pheromone-response conjugative plasmid. All of the MRSA isolates accepted the plasmid DNA with similar transfer efficiencies (∼10−7/donor CFU) except for one isolate, MRSA8, for which conjugation was not successful. The MRSA isolates were also tested as recipients in mating experiments between anE. faecalisisolate with an Inc18-likevanAplasmid that was isolated from a VRSA case patient. Conjugative transfer was successful for 3/5 MRSA isolates. Successful MRSA recipients carried a pSK41-like plasmid, a staphylococcal conjugative plasmid, whereas the two unsuccessful MRSA recipients did not carry pSK41. The transfer of a pSK41-like plasmid from a successful MRSA recipient to the two unsuccessful recipients resulted in conjugal transfer of the Inc18-likevanAplasmid fromE. faecalisat a frequency of 10−7/recipient CFU. In addition, conjugal transfer could be achieved for pSK41-negative MRSA in the presence of a cell-free culture filtrate fromS. aureuscarrying a pSK41-like plasmid at a frequency of 10−8/recipient CFU. These results indicated that a pSK41-like plasmid can facilitate the transfer of an Inc18-likevanAplasmid fromE. faecalistoS. aureus, possibly via an extracellular factor produced by pSK41-carrying isolates.

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Kirienko, Anna N., Nadezhda A. Vishnevskaya, Anna B. Kitaeva, Oksana Yu Shtark, Polina Yu Kozyulina, Richard Thompson, Marion Dalmais, Abdelhafid Bendahmane, Igor A. Tikhonovich, and Elena A. Dolgikh. "Structural Variations in LysM Domains of LysM-RLK PsK1 May Result in a Different Effect on Pea–Rhizobial Symbiosis Development." International Journal of Molecular Sciences 20, no. 7 (April 1, 2019): 1624. http://dx.doi.org/10.3390/ijms20071624.

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Lysin-motif receptor-like kinase PsK1 is involved in symbiosis initiation and the maintenance of infection thread (IT) growth and bacterial release in pea. We verified PsK1 specificity in relation to the Nod factor structure using k1 and rhizobial mutants. Inoculation with nodO and nodE nodO mutants significantly reduced root hair deformations, curling, and the number of ITs in k1-1 and k1-2 mutants. These results indicated that PsK1 function may depend on Nod factor structures. PsK1 with replacement in kinase domain and PsSYM10 co-production in Nicotiana benthamiana leaves did not induce a hypersensitive response (HR) because of the impossibility of signal transduction into the cell. Replacement of P169S in LysM3 domain of PsK1 disturbed the extracellular domain (ECD) interaction with PsSYM10′s ECD in Y2H system and reduced HR during the co-production of full-length PsK1 and PsSYM0 in N. benthamiana. Lastly, we explored the role of PsK1 in symbiosis with arbuscular mycorrhizal (AM) fungi; no significant differences between wild-type plants and k1 mutants were found, suggesting a specific role of PsK1 in legume–rhizobial symbiosis. However, increased sensitivity to a highly aggressive Fusarium culmorum strain was found in k1 mutants compared with the wild type, which requires the further study of the role of PsK1 in immune response regulation.

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Більше джерел

Дисертації з теми "PSKH1"

Sarosh, Alvina. "DNA replication and segregation in Staphylococcus aureus." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16476.

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Antibiotic resistant strains of S. aureus are responsible for hospital-acquired infections around the world, and also cause serious infections in the wider community, thereby posing a serious threat to human health. Resistance genes may be chromosomally encoded and/or carried by one or more plasmids. Efficient partitioning of replicated chromosomes and plasmids ensures their faithful inheritance. The S. aureus chromosome carries a putative partitioning gene, parB, and predicted parS sites at which ParB might act. Analysis of a S. aureus parB mutant revealed an increased frequency of anucleate cell production under some conditions. ParB was also shown to bind specifically to three parS sites. The partitioning system of the S. aureus multiresistance plasmid pSK41 comprises two genes in an operon, parM and parR, and a centromere site, parC. ParM interacts with ParR bound to parC repeats to form a partitioning complex. Binding of ParR to parC also mediates transcriptional autoregulation of the operon. Results described here indicate that the minimal parC region required for function is larger than anticipated. The pSK41 orf86 gene is located upstream of the replication initiation gene, rep, but its function was a mystery. Orf86 was shown to negatively regulate rep expression. It repressed transcription from the rep promoter, and reduced the copy number of pSK41 mini-replicons. Transcription of orf86 is dependent on transcripts from the RNAI promoter, which therefore mediates the production of two RNA species that regulate rep expression; a small antisense transcript RNAI that inhibits Rep translation, and orf86 mRNA that is translated into Orf86, which inhibits rep transcription. Based on its newly described role in copy number control, orf86 was renamed cop. Detailed knowledge about DNA replication and segregation mechanisms arising from these studies may contribute to the development of strategies to combat the threat of antibiotic resistant S. aureus.

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Chan, Helena. "Characterisation of a plasmid segregational stability determinant, par, of the staphylococcal multiresistance plasmid, pSK1." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17714.

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Staphylococcus aureus is a bacterium that is a common cause of hospital-acquired infections that is also becoming a significant cause of serious community-acquired infections. Many clinical strains of S. aureus carry extrachromosomal DNA elements called plasmids, which often encode genes conferring antimicrobial resistance. Plasmid segregation mechanisms such as active partitioning systems ensure that low copy-number plasmids are accurately segregated and inherited by progeny cells upon division, even in the absence of selection. The staphylococcal multiresistance plasmid, pSK1, contains a gene, par, which enhances the efficiency of plasmid inheritance, possibly via an active plasmid partitioning system. Active plasmid partitioning systems characterised thus far encode two individual proteins – a DNA-binding protein and a force-generating NTPase protein. Although the pSK1 par system is widespread among non-conjugative staphylococcal plasmids, it differs from characterised plasmid partitioning systems by encoding only a single protein, Par. Previous studies have shown that pSK1 Par exhibits both DNA-binding and multimerisation activities that are common to characterised partitioning proteins. Much remains to be elucidated about the mechanism by which pSK1 par facilitates efficient plasmid inheritance. This knowledge gap will be addressed by this experiments described in this thesis, which aim to 1) determine the functional significance the predicted Par domains, particularly the disordered C-terminal domain, 2) identify any host factors that interact with Par, and 3) determine the localisation of Par and plasmid DNA during plasmid segregation in S. aureus. These experiments are designed to provide a broader understanding of the mechanism of par-mediated plasmid inheritance, and provide greater insight into possible methods of disrupting the spread and maintenance of antimicrobial resistance plasmids.

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Mosher, Stephen [Verfasser], and Thorsten [Akademischer Betreuer] Nürnberger. "The tyrosine-sulfated peptide receptors PSKR1 and PSY1R modulate Arabidopsis immune responses / Stephen Mosher ; Betreuer: Thorsten Nürnberger." Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1163235083/34.

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Kaufmann, Christine [Verfasser], Margret [Akademischer Betreuer] Sauter, and Dietrich [Gutachter] Ober. "Regulation and activities of phytosulfokine receptor PSKR1 in Arabidopsis thaliana / Christine Kaufmann ; Gutachter: Dietrich Ober ; Betreuer: Margret Sauter." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1232726443/34.

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DeMille, Desiree. "Identifying and Characterizing Yeast PAS Kinase 1 Substrates Reveals Regulation of Mitochondrial and Cell Growth Pathways." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5930.

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Glucose allocation is an important cellular process that is misregulated in the interrelated diseases obesity, diabetes and cancer. Cells have evolved critical mechanisms for regulating glucose allocation, one of which is sensory protein kinases. PAS kinase is a key sensory protein kinase that regulates glucose allocation in yeast, mice and man; and is a novel therapeutic target for the treatment of metabolic diseases such as obesity, diabetes and cancer. Despite its importance, the molecular mechanisms of PAS kinase function are largely unknown. Through large-scale protein-interaction studies, we have identified 93 novel binding partners for PAS kinase which help to expand its role in glucose allocation as well as suggest novel roles for PAS kinase including mitochondrial metabolism, cell growth/division, protein modification, stress tolerance, and gene/protein expression. From a subset of these binding partners, we identified 5 in vitro substrates of PAS kinase namely Mot3, Utr1, Zds1, Cbf1 and Pbp1. Additionally, we have further characterized Pbp1 and Cbf1 as PAS kinase substrates through both in vitro and in vivo evidence as well as phenotypic analysis. Evidence is provided for the PAS kinase-dependent phosphorylation and activation of Pbp1, which in turn inhibits cell proliferation through the sequestration of TORC1. In contract, PAS kinase-dependent phosphorylation of Cbf1 inhibits its activity, decreasing cellular respiration. This work elucidates novel molecular mechanisms behind PAS kinase function in both mitochondrial and cell growth pathways in eukaryotic cells, increasing our understanding of the regulation of central metabolism.

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Vorálek, Jan. "Telemetrický archiv družic." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413153.

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This thesis deals with a design of telemetry archive of PSAT, PSAT-2 and BRICSat sattelites. This telemetry data need to be extracted from SDR IQ records. The thesis contains a Doppler effect theory and description of structure of telemetry data. Then it presents a design of a program for Doppler effect correction, demodulation and decoding of these records and saving the data to telemetry archive. Thesis also deals with analysis of decoded data.

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Книги з теми "PSKH1"

Bobrov, A. V. Zagadki Pskhu: Istoricheskiĭ ocherk. Moskva: Buki Vedi, 2017.

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Pskhu, A. V. Uravneniia v chastnykh proizvodnykh drobnogo poriadka / A.V. Pskhu ; [Otv. redaktor A.P. Soldatov ... [et al.]. Moskva: "Nauka ", 2005.

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Lafreniere, Bernie. Nifty E-Z Guide to Psk31 Operation. CreateSpace, 2008.

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Get on the air with HF digital: The beginner's guide to PSK31, RTTY and more! Newington, CT: ARRL, 2011.

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Arman, Aaron. Hf Digital: The Complete QuickStart Guide for Setting up Your First Hf Station and Getting on the Air Using Jt-65, Ft8, Rtty, Psk31, Mfsk and More. Independently Published, 2018.

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Частини книг з теми "PSKH1"

Tsvizhba, Larisa I. "Report of the Captain of the General Staff Count Pavel Ippolitovich Kutaysov." In Abkhazia in Russian Literature of the 19th — 20th Centuries: in 3 vols. Vol. 2, 135–59. A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, 2023. http://dx.doi.org/10.22455/arl-2023-2-135-159.

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The Russian State Military Historical Archive contains the “Case of the reconnaissance carried out by the General Staff Captain, Count Kutaisov of the lands of the Dzhigets and part of the lands of the Ubykhs adjacent to the eastern coast of the Black Sea and of the inspection of roads running in this part of the region,” which contains two documents. This is a memo about the societies — Dzhiget and Ubykh, and a description of the roads from Gagra towards Gelendzhik. Kutaisov’s materials do not have an exact date, although it is known that he collected information and wrote it down between 1860 and the beginning of 1864. Kutaisov in his materials gives detailed information about the societies of the studied region, about influential and noble families, indicating their status in society, places of their settlement, indicating the boundaries and indicating the number of households in each of them, about the complex political situation with Russia. The description of the road from Gagra to the former Navaginsky fortification (the mouth of the Sochi River) should be considered from the point of view of strategic importance. In it, Kutaisov notes how one or another settlement can be occupied, which roads are convenient for troops to pass, which roads require development for the passage of military detachments to mountain communities, where danger is expected. This speaks of preparations for active military operations by detachments that were preparing to march from different points towards the mountain communities of Pskhu, Akhchipshu in order to finally bring them into submission, which will happen on May 21, 1864.

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