Добірка наукової літератури з теми "QT.37"
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Статті в журналах з теми "QT.37":
1
Licata, Anthony, and Alistair Savage. "Hecke algebras, finite general linear groups, and Heisenberg categorification." Quantum Topology 4, no. 2 (2013): 125–85. http://dx.doi.org/10.4171/qt/37.
2
Séguéla, Pierre-Emmanuel, Jean-Christophe Rozé, and Véronique Gournay. "Evolution of the QT interval in premature infants: a preliminary study." Cardiology in the Young 22, no. 4 (December 19, 2011): 430–35. http://dx.doi.org/10.1017/s1047951111001958.
Анотація:
AbstractBackgroundThe association between long QT interval and sudden infant death syndrome has been clearly established. Several studies have been conducted to determine the evolution of the QT interval in childhood from birth, but only in full-term newborns. However, data on the QT interval in pre-term infants are extremely scarce. The objective was to describe the development of the QT interval in premature infants.Material and methodsIn a prospective monocentric study in a neonatal intensive care unit, pre-term newborns born before 37 weeks of gestation without congenital heart disease, family history of long QT, unstable haemodynamic status, or administration of drugs inducing QT interval prolongation were included with parental consent. An electrocardiogram was recorded in similar conditions weekly until discharge in each child. The corrected QT was calculated with Bazett's formula.ResultsIn all, 309 echocardiograms were recorded in 87 children, with gestational age ranging from 24–36 weeks. QT first increased after birth in very premature infants – less than 30 weeks of gestation – and then started to decrease, whereas it only decreased in more mature infants. When plotted against postmenstrual age, QT first increased, and then decreased after 32 weeks.DiscussionOur data suggest that the QT interval varies with postmenstrual age in very premature infants, reaching a peak at 32 weeks. These developmental changes may induce specific vulnerability to QT-lengthening medications in premature infants. This study underlines the need for specific pharmacological studies in this population.
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Orosz, Andrea, István Baczkó, Viktória Nagy, Henriette Gavallér, Miklós Csanády, Tamás Forster, Julius Gy Papp, András Varró, Csaba Lengyel, and Róbert Sepp. "Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy." Canadian Journal of Physiology and Pharmacology 93, no. 9 (September 2015): 765–72. http://dx.doi.org/10.1139/cjpp-2014-0526.
Анотація:
Stratification models for the prediction of sudden cardiac death (SCD) are inappropriate in patients with hypertrophic cardiomyopathy (HCM). We investigated conventional electrocardiogram (ECG) repolarization parameters and the beat-to-beat short-term QT interval variability (QT-STV), a new parameter of proarrhythmic risk, in 37 patients with HCM (21 males, average age 48 ± 15 years). Resting ECGs were recorded for 5 min and the frequency corrected QT interval (QTc), QT dispersion (QTd), beat-to-beat short-term variability of QT interval (QT-STV), and the duration of terminal part of T waves (Tpeak–Tend) were calculated. While all repolarization parameters were significantly increased in patients with HCM compared with the controls (QTc, 488 ± 61 vs. 434 ± 23 ms, p < 0.0001; QT-STV, 4.5 ± 2 vs. 3.2 ± 1 ms, p = 0.0002; Tpeak–Tend duration, 107 ± 27 vs. 91 ± 10 ms, p = 0.0015; QTd, 47 ± 17 vs. 34 ± 9 ms, p = 0.0002), QT-STV had the highest relative increase (+41%). QT-STV also showed the best correlation with indices of left ventricular (LV) hypertrophy, i.e., maximal LV wall thickness normalized for body surface area (BSA; r = 0.461, p = 0.004) or LV mass (determined by cardiac magnetic resonance imaging) normalized for BSA (r = 0.455, p = 0.015). In summary, beat-to-beat QT-STV showed the most marked increase in patients with HCM and may represent a novel marker that merits further testing for increased SCD risk in HCM.
4
Olson, Stephen C., Ann Marie Horvath, Barbara M. Michniewicz, Allen J. Sedman, Wayne A. Colburn, Peter G. Welling, and Stephen C. Olson. "The Clinical Pharmacokinetics of Quinapril." Angiology 40, no. 4_part_2 (April 1989): 351–59. http://dx.doi.org/10.1177/000331978904000404.
Анотація:
Quinapril (Q) and quinaprilat (QT) pharmacokinetics are dose pro portional following single oral 2.5- to 80-mg Q doses. Q absorption and hy drolysis to QT is rapid with peak Q and QT concentrations occurring one and two hours postdose, respectively. Peak plasma QT concentrations were approximately fourfold higher than those of Q (923 vs 207 ng/mL follow ing 40-mg Q). Dose-proportional QT area under the curve and dose-inde pendent percent of dose excreted in urine as QT demonstrate that the ex tent of Q conversion to QT is con stant over the dose range studied. Q and QT were eliminated from plasma with apparent half-lives of 0.8 and 1.9 hours and apparent plasma clear ances of 1,850 and 220 mL/min, re spectively, over the 2.5- to 80-mg dose range. Following oral 14C-Q, 61% and 37% of radiolabel was recovered in urine and feces, respectively. Q plus QT accounted for 46% of radioactiv ity circulating in plasma and 56% of that excreted in urine. Metabolism to compounds other than QT is not extensive. Two diketo piperazine metabolites of Q have been identified in plasma and urine, with approximately 6% of an admin istered dose excreted in urine as each of these metabolites. Peak plasma concentrations of these metabolites are similar to that of Q, and each is eliminated rapidly with a half-life of approximately one hour. Urinary ex cretion profiles indicate the presence of other minor metabolites. In summary, the absorption of Q and conversion to QT is rapid and dose-proportional, subsequent clear ance of both Q and QT is independ ent of dose, and metabolism to compounds other than QT is not ex tensive.
5
Arpaci, Dilek, Mustafa Volkan Demir, Tayfun Garip, and Ali Tamer. "A Case of QT Prolongation Associated with Panhypopituitarism." Case Reports in Endocrinology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/989745.
Анотація:
We describe a 37-year-old patient with panhypopituitarism who experienced symptoms and signs of hormonal insufficiency and QT prolongation on electrocardiogram without electrolyte disturbances. After hormonal (steroidal and thyroid) replacement therapy electrocardiographic findings were normalized. Hormonal disorders should be considered as a cause of long QT intervals which may lead to torsade de pointes, even if plasma electrolyte levels are normal, because life-threatening arrhythmia is treatable by supplementation of the hormone that is lacking.
6
SOYSAL GÜNDÜZ, Özgül, and Kezban ARMAGAN. "Increased QT dispersion and related factors in patients with systemic sclerosis." Anatolian Current Medical Journal 4, no. 4 (October 22, 2022): 368–73. http://dx.doi.org/10.38053/acmj.1132856.
Анотація:
Introduction: Cardiac arrhythmias and sudden death may occur as a result of ventricular myocardial fibrosis or ischemia in patients with systemic sclerosis (SSc). QT prolongation and QT dispersion, which facilitate the development of ventricular fibrillation, are important cardiac problems associated with increased mortality. In this study, we aimed to investigate the prevalence of corrected QT dispersion (cQTD) and related factors in our patients with systemic sclerosis compared to healthy controls.
Material and Method: The 12-lead electrocardiograms with a rate of 25 mm/s of patients with no previous history of cardiovascular disease and controls were analyzed. cQTD was defined as the difference between the maximum QT interval and the minimum QT interval. Nailfold capillaroscopy examination was performed. Disease activity was evaluated using revised European Scleroderma Study Group activity index.
Results: Forty-nine SSc patients (45 females, mean age 53.26±10.63 years, and disease duration 8.0 (1-25) years) and 41 controls (37 females, mean age 49.29±8.02 years) were included. While the frequency of smoking was significantly higher in controls (p=0.025), erythrocyte sedimentation rate was higher in patients (p
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Shea, Kevin G., Jessica F. Burlile, Connor G. Richmond, Henry B. Ellis, Philip L. Wilson, Peter D. Fabricant, Stephanie Mayer, et al. "Quadriceps Tendon Graft Anatomy in the Skeletally Immature Patient." Orthopaedic Journal of Sports Medicine 7, no. 7 (July 2019): 232596711985657. http://dx.doi.org/10.1177/2325967119856578.
Анотація:
Background:The quadriceps tendon (QT) is increasingly considered for primary and revision anterior cruciate ligament reconstruction in skeletally immature patients, as it may be harvested as a purely soft tissue graft with considerable tissue volume. Because of distinct rectus tendon (RT) separation from the QT complex, the potential for RT retraction exists and could lead to QT weakness after QT graft harvest.Purpose:To describe the anatomy of the pediatric QT and clarify decussation of the RT and QT to avoid the risk of delayed RT retraction and QT weakness after QT graft harvest.Study Design:Descriptive epidemiology study.Methods:Nine cadaveric knee specimens (aged 4-11 years) underwent gross dissection. Coronal-plane width and depth of the QT were measured at intervals proximal to the superior pole of the patella at distances of 0.0, 0.5, 1.0, and 1.5 times the length of the patella. The distance was measured from the superior patellar pole to the point of RT separation from the remainder of the deeper/posterior QT.Results:The median patellar length was 28 mm (interquartile range, 26-37 mm). The coronal-plane width of the QT was larger superficially/anteriorly when closest to the patella but wider when measured deeper/posteriorly as the tendon extended proximally. The median distance between the superior pole of the patella and RT separation from the QT was 0.95 times the patellar length. The distance to widening of the deeper/posterior aspect of the QT was 1.14 times the patellar length proximal to the patella.Conclusion:The RT begins a distinct separation from the QT above the superior pole of the patella at a median of 0.95 times the patellar length in skeletally immature specimens. The deeper/posterior aspect of the QT begins to increase in coronal-plane width proximally after a distance of 1.14 times the patellar length above the knee, while the superficial/anterior aspect of the tendon continues to narrow. Awareness of the separation of the RT from the QT, and the coronal-plane width variation aspects of the QT proximally, is important for surgeons utilizing the QT as a graft to avoid inadvertent release of the RT from the rest of the QT complex.
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Määttänen, Ilmari, Niklas Ravaja, Pentti Henttonen, Sampsa Puttonen, Kristian Paavonen, Heikki Swan, and Taina Hintsa. "Type 1 long QT syndrome and psychological stress in a laboratory setting." Journal of Health Psychology 25, no. 9 (January 22, 2018): 1213–21. http://dx.doi.org/10.1177/1359105317751617.
Анотація:
Trait-like sensitivity to stress in long QT syndrome patients has been documented previously. In addition, mental stress has been associated with symptomatic status of long QT syndrome. We examined whether the symptomatic type 1 long QT syndrome patients would be more sensitive to mental stress compared to asymptomatic patients and whether there would be differences in task-related physiological stress reactions between type 1 long QT syndrome patients and healthy individuals. The study population consisted of 21 symptomatic and 23 asymptomatic molecularly defined KCNQ1 mutation carriers, their 32 non-carrier relatives and 46 non-related healthy controls, with mean ages of 37, 39, 35 and 23 years, respectively. Electrocardiography was utilised to calculate inter-beat interval and high frequency and low frequency heart rate variability. Blood pressure was measured and mean arterial pressure and pulse pressure were calculated. Stress was induced using three different tasks: mental arithmetic, reaction time and public speech. Stress responses of symptomatic and asymptomatic type 1 long QT syndrome patients were not statistically different in any of the stress tasks. Short-term physiological stress reactivity of symptomatic type 1 long QT syndrome patients appears to be normal and does not enhance the risk assessment of asymptomatic mutation carriers.
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Brady, William, Daniel DeBehnke, Dennis Laundrie, and Jeffrey A. Skiles. "21. Prolonged QT Intervals in Patients with Out-of-Hospital Ventricular Tachycardia Cardiac Arrest." Prehospital and Disaster Medicine 11, S2 (September 1996): S40. http://dx.doi.org/10.1017/s1049023x00045854.
Анотація:
Objective: To determine the prevalence and outcome of out-of-hospital ventricular tachycardia (VT) cardiac arrest with a prolonged QT interval and to identify the subset with torsades de pointes (TdP).Methods: Design: Retrospective review. Setting: Fire department-based paramedic system. Participants: Non-traumatic VT cardiac arrest (1/91-12/94) with a supraventricular perfusing rhythm (SVPR) and a measurable QT interval. Interventions: QT interval was measured from a SVPR and corrected QT interval (QTc) was calculated (prolonged if ≥0.45 sec). VT was classified as polymorphic or monomorphic.Results: 190 patients met inclusion criteria. 51% of patients had a prolonged QTc (PQTc). The overall hospital discharge rate was 28.4%. No difference with respect to paramedic-witnessed arrests in each QTc group was found (25.8% normal QTc [NQTc] vs. 27.8% PQTc; p = 0.752). Patients with PQTc were less likely to be discharged from the hospital (19.6% vs. 37.6%; p = 0.01). Patients with PQTc were not more likely to have PVT (37% vs. 40%; p = 0.705). 16 (8.4%) patients had TdP. 27.8% of TdP and 26.8% of non-TdP patients were discharged (p = 0.912).
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Rhatomy, Sholahuddin, Roy Lisang, Noha Roshadiansyah Soekarno, and Bambang Kisworo. "Evaluation of Quadriceps Strength Post-medial Patellofemoral Ligament Reconstruction Using Quadriceps Tendon Autografts." Open Access Macedonian Journal of Medical Sciences 8, A (December 20, 2020): 943–46. http://dx.doi.org/10.3889/oamjms.2020.5551.
Анотація:
BACKGROUND: Medial patellofemoral ligament (MPFL) reconstruction using quadriceps tendon (QT) grafts provides favorable results with minimal complications and can be performed in patients with open epiphyseal plates. Following MPFL reconstruction using QT grafts, the outcomes have been evaluated, but the residual quadriceps strength (QS) has never been evaluated.
AIM: We analyzed the knee’s range of motion (ROM), thigh circumference (TC), and QS at donor leg sites compared with those at contralateral healthy sites after MPFL reconstruction. The hypothesis was that there is no morbidity at donor sites.
MATERIALS AND METHODS: Patients who underwent MPFL reconstruction using QT autografts between January and December 2017 were recruited. The ROM, TC, and QS were measured 6 months postoperatively.
RESULTS: Twenty-one patients (8 men, 14 women; mean age, 28.40 ± 10.78 years [range, 16–45]) were included in the study. The TCs at the donor and contralateral sites (medians: 37 and 37.5 cm, respectively) showed no significant difference (p = 0.64). QS measurements showed means of 182 ± 4.6 N and 190 ± 4.7 N at the donor and contralateral sites, respectively (p = 0.376). There were no ROM deficits.
CONCLUSIONS: The ROM, TC, and QS at donor sites were similar to those at contralateral sites. The QT is a suitable graft for MPFL reconstruction.
Дисертації з теми "QT.37":
1
Roina, Yaëlle. "Développement de prothèses ePTFE antibactériennes implantables pour les tissus mous." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCE002.
Анотація:
Bien que largement utilisé dans le domaine de la chirurgie et du médical plus généralement, le polytétrafluoroéthylène expansé (ePTFE) présente également des inconvénients importants, comme celui de la colonisation de bactéries multirésistantes et la formation de biofilms qui peuvent engendrer de graves conséquences sur la santé des patients. Il existe un besoin urgent d'empêcher ces colonisations bactériennes de survenir sans utilisation d'antibiotiques. C'est à cette fin que notre projet intervient. Ce manuscrit présente une nouvelle méthode de fonctionnalisation de surface du ePTFE consistant à mélanger des composés aliphatiques aminé ainsi qu'un métal alcalin, le lithium. Cette solution conduit à la défluoration et l'amination de surface du matériau, et caractérisé par spectroscopie XPS et IR-ATR. Ces traitements chimiques entrainent des modifications de propriétés physico-chimiques importantes comme la rigidification de la surface, ou son changement en surface hydrophile. Ces matériaux aminés sont ensuite fonctionnalisés par physi ou chimisorption de molécules antibactériennes. Par la suite, ces matériaux sont évalués par des tests de cytotoxicité indirecte. Six matériaux ont été sélectionnés par ce moyen comme potentiellement éligibles à une application médicale. Leur efficacité antibactérienne contre 6 souches à l'origine de maladies nosocomiales est enfin évaluée. Selon le composé aminé ou la molécule antibactérienne utilisés, des tendances se dessinent sur le nombre de bactéries affectées par les matériaux. Un des matériaux fonctionnalisés se démarque des autres, avec une probable activité antibactérienne sur toutes les souches testéesAlthough widely used in the field of surgery and, more generally, medicine, ePTFE also has significant drawbacks, such as the colonization of mÛiti-resistant bacteria which can have serious consequences on the health of patients. There is an urgent need to prevent these bacterial colonizations from occurring, without the use of antibiotics. It is to this end that our project intervenes. This manuscript presents a new surface functionalization method consisting in mixing aliphatic amino compounds and an alkali metal, lithium. This solution leads to defluorination and surface amination of the material, which have been proven by XPS and IRATR spectroscopy. These chemical treatments Jead to modifications of important physico-chemical properties such as the stiffening of the surface, or its change into a hydrophilic surface. These amino materials are then functionalized by immersion or grafting of antibacterial molecules. Subsequently, these materials are evaluated by indirect cytotoxicity assays. Six materials were selected by this mean as potentially eligible for medical application. Their antibacterial efficiency against 6 strains causing nosocomial diseases is then evaluated. Depending on the amino compound or the antibacterial molecule used, trends emerge in the number of bacteria affected by the materials. One of the functionalized materials stands out from the others, with probable antibacterial activity on ail the strains tested
Тези доповідей конференцій з теми "QT.37":
1
Soares Junior, Antônio Luiz da Costa, Carolina Del Negro Visintin, Bruno Goia de Araújo Rossi, and Stephanie Aragão Lusoli Vicensotti. "Relato de caso: a importância da imuno-histoquímica em tumores sólido-císticos versus triplo-negativos." In 44° Congresso da SGORJ - XXIII Trocando Ideias. Zeppelini Editorial e Comunicação, 2020. http://dx.doi.org/10.5327/jbg-0368-1416-2020130235.
Анотація:
Introdução: O câncer (CA) de mama é o tumor sólido mais comum entre as mulheres. O tumor de mama triplo-negativo (TNBC) não possui receptor de estrogênio (RE), progesterona (RP) e fator de crescimento epidérmico humano 2 (HER2), e representa de 15 a 20% de todos os CA de mama. O TNBC costuma ser agressivo e de mau prognóstico pelo seu risco de recorrência à distância nos dois primeiros anos após o diagnóstico e pela rápida progressão após a recidiva. Objetivo: Afirmar a importância da imuno-histoquímica (IMQ) aos tumores sólidos-císticos para tratamento e prognóstico mais eficientes. Material e Métodos: Coleta de dados e análise de prontuário de paciente acompanhada em um ambulatório de Mastologia. Resultados: Paciente branca, 37 anos, G3P3C3, histórico de CA mama em tia materna, nódulo palpável há 6 meses em mama esquerda (E) de crescimento progressivo, acelerado, doloroso à palpação. Ao exame físico: mama direita normal e mama E com nódulo de 17 × 21 cm. Em ultrassom (US), cisto septado com vascularização (BIRADS 4a); e em punção aspirativa por agulha fina (PAAF), resultado de parênquima mamário com microcistos. Evoluiu com sinais flogísticos em mama E, sendo precisas duas drenagens com saída de até 280 mL de líquido serosanguinolento. Marcada nodulectomia, com resultado de carcinoma ductal invasivo GH3, margens livres e negativo para RE, RP e HER2. Estadiamento com linfonodomegalia axilar E. Iniciou quimioterapia (QT) e aguarda teste genético. Se negativo, esvaziamento axilar (EA). Se positivo, mastectomia bilateral com EA à E e ooforectomia aos 40 anos. O CA de mama é subdividido em luminal A, luminal B, superexpressão de HER2 e TNBC. Possuem evolução clínica diferente e, somados às características clínico-patológicas, definirão o tratamento. HER2 e TNBC têm padrão patológico mais desfavorável e com menos sobrevida em comparação aos outros. TNBC à mamografia geralmente tem formas arredondadas e ovais. Ao US, tem lesões não paralelas à pele, com halo hipoecogênico bem marcado e com reforço posterior. Estudos mostram que mulheres afro-americanas, em pré-menopausa, a alta paridade e o curto período de amamentação aumentam o risco ao TNBC. Disseminação com maior afinidade por metástases cerebrais e pulmonares e menor para ossos. Na ocorrência, biópsia para avaliação hormonal. O alto número de infiltrado tumoral propicia ao TNBC marcador preditivo de respostas para imunoterapia e sobrevida com a QT. QT neoadjuvante beneficia a diminuição do tumor antes da cirurgia. É indefinido o tratamento para o TNBC avançado. Radiação pode aumentar a ação da imunoterapia por aumentar a carga mutacional dos tumores, acelerar a apresentação do antígeno e age diminuindo imunossupressores no ambiente tumoral. A remissão completa da patologia deve-se, em geral, ao uso de QT com taxano e sais de platina à antracilina. Conclusão: O TNBC deve ser tratado assim que diagnosticado. Atenção à radiologia e à IMQ, essa que não é realizada em todos os serviços, para um prognóstico menos incerto ao paciente. O TNBC carece de maiores estudos para a imunoterapia.
2
Evans, R. M., and M. A. Packham. "THE EFFECT OF ENZYMATIC TREATMENT OF RABBIT PLATELETS ON THE BINDING OF IMMUNOGLOBULIN G TO THE SURFACE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643504.
Анотація:
As shown previously, cleavage of surface glycoproteins on the platelet membrane shortens platelet survival. Since immunoglobulins have been implicated in the condition of idiopathic thrombocytopenic purpura in which patients have an elevated level of platelet-associated immunoglobulin G (I g G) and shortened platelet survival, we measured the binding of IgG to rabbit platelets that had been treated with neuraminidase or plasmin, to determine whether increased IgG binding to these platelets might be the signal that leads to their accelerated clearance. Rabbit platelets were washed and resuspended in calcium-free Tyrode-albumin solution (1.0 x 106/ μL), pH 6.5, and then incubated with either neuraminidase (0.1 U/mL at 22°C) or plasmin (activity: 1.6 ymol BAEE/min/mL platelet suspension at 37¼C) for 30 min. The platelets were then centrifuged and resuspended in heat-inactivated rabbit serum for 30 min to allow IgG to bind to the surface. After additional washing steps to remove non-specifically bound IgG, the amount Qt IgG that associated with the platelets was measured using an 125I-labeled goat anti-rabbit IgG binding assay. Binding data were analyzed by plotting the calculated fg of IgG bound/platelet versus the amount of 125-1 goat anti-rabbit IgG added. The binding curves for both neuraminidase and plasmin indicated significantly increased amounts of specifically bound IgG compared to control platelets. At a concentration of 30 μg/mL of labeled goat antirabbit IgG added, the amount of label associated with untreated rabbit platelets had plateaued at 0.36± 0.11 fg/platelet whereas the amount associated with neuraminidase-treated platelets was 5 times greater and with pi asmin-treated platelets, 1.5 times greater, and neither had plateaued. The results obtained with plasmin are of particular interest since this proteolytic enzyme shortens platelet survival and is present in vivo during thromboembolic events. These results indicate that IgG binds specifically to the surface of rabbit platelets following enzymatic alterations of the membrane glycoproteins and therefore may represent at least one mechanism that determines which platelets are cleared by the reticuloendothelial system.