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Готові списки джерел за темами / Quantitative determination for the biological activity using NMR / Статті в журналах

Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: Quantitative determination for the biological activity using NMR.

Статті в журналах з теми "Quantitative determination for the biological activity using NMR"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Premchand, Patil Deepak V. Nagarale and Bhata R. Chaudhari*. "RECENT ADVANCES AND APPLICATIONS OF TELMISARTAN." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3935–45. https://doi.org/10.5281/zenodo.1035249.

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Telmisartan is pharmacologically active molecule, Here we reviewed some synthetic methods and their application like angiotensin II receptor, quantitative determination for the biological activity using NMR, restrict NFAT nuclear translocation and etc..

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2

Larive, Cynthia K., Dimuthu Jayawickrama, and Laszlo Orfi. "Quantitative Analysis of Peptides with NMR Spectroscopy." Applied Spectroscopy 51, no. 10 (1997): 1531–36. http://dx.doi.org/10.1366/0003702971939055.

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The determination of peptide concentration with 1H nuclear magnetic resonance (NMR) spectroscopy using an internal standard or an external standard in a sealed glass capillary was investigated for three tyrosine-containing tripeptides. Trimethylsilylpropionic acid (TSP) and maleic acid were tested as external standards for quantitation by proton NMR. Although comparable results were obtained for either standard, the performance of maleic acid was found to be superior because of its better long-term stability in the sealed capillary. Loss of TSP from solution occurred over time due to adsorptio

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3

RAKS, V. A. "INOSITOLS: BIOLOGICAL ROLE AND APPLICATION, METHODS OF EXTRACTION FROM PLANT RAW MATERIALS AND DETERMINATION, BIOTECHNOLOGICAL SYNTHESIS." Biotechnologia Acta 17, no. 3 (2024): 29–46. http://dx.doi.org/10.15407/biotech17.03.029.

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The aim of the work was to review modern extraction, detection and quantification analytical methods of inositols and their derivatives. Methods. Inositols are extracted from vegetable raw materials by methods of liquid extraction, under pressure, microwave extraction and supercritical fluid extraction. Quantitatively analyzed by methods of gas and liquid chromatography with preliminary derivatization. The structure of inositols can be determined by the NMR spectroscopy. Results. Inositols and their derivatives are biologically active compounds, wich are involved in the egulation of the intrac

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4

Rogov, A. V., and G. V. Mokrov. "Determination of the composition of pharmaceutical substances used in drugs with antiarrhythmic activity." Pharmacokinetics and Pharmacodynamics, no. 4 (January 22, 2024): 95–109. http://dx.doi.org/10.37489/2587-7836-2023-4-95-109.

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Cardiac arrhythmias are the most common pathologies of the cardiovascular system. Allapinin® and Allaforte® from “Pharmcenter VILAR” are effective IC-class antiarrhythmic agents. The main component of these drugs is a pharmaceutical substance with INN: lappaconitine hydrobromide, which in addition to lappaconitine hydrobromide itself, contains impurities of other diterpene alkaloids. This work is devoted to a detailed analysis of the alkaloid composition of a new pharmaceutical substance isolated from roots and rhizomes, as well as from the aerial part of plants of the genus Aconite (monkshood

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5

Satpathi, Sagar, Tamaki Endoh, Peter Podbevšek, Janez Plavec, and Naoki Sugimoto. "Transcriptome screening followed by integrated physicochemical and structural analyses for investigating RNA-mediated berberine activity." Nucleic Acids Research 49, no. 15 (2021): 8449–61. http://dx.doi.org/10.1093/nar/gkab189.

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Abstract Non-coding RNAs are regarded as promising targets for the discovery of innovative drugs due to their abundance in the genome and their involvement in many biological processes. Phytochemicals (PCs) are the primary source of ligand-based drugs due to their broad spectrum of biological activities. Since many PCs are heterocyclic and have chemical groups potentially involved in the interaction with nucleic acids, detailed interaction analysis between PCs and RNA is crucial to explore the effect of PCs on RNA functions. In this study, an integrated approach for investigating interactions

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6

Roman, Roxana, Lucia Pintilie, Miron Teodor Căproiu, et al. "New N-acyl Thiourea Derivatives: Synthesis, Standardized Quantification Method and In Vitro Evaluation of Potential Biological Activities." Antibiotics 12, no. 5 (2023): 807. http://dx.doi.org/10.3390/antibiotics12050807.

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New N-acyl thiourea derivatives with heterocyclic rings have been synthesized by first obtaining isothiocyanate, which further reacted with a heterocyclic amine, characterized by (FT-IR, NMR spectroscopy and FT-ICR) and tested for their in vitro antimicrobial, anti-biofilm and antioxidant activities to obtain a drug candidate in a lead-optimization process. From the tested compounds, those bearing benzothiazole (1b) and 6-methylpyridine (1d) moieties revealed anti-biofilm activity against E. coli ATCC 25922 at MBIC values of 625 µg/mL. Compound 1d exhibited the highest antioxidant capacity (~4

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7

Ryazanova, Tatyana K., Vladimir A. Kurkin, Anna A. Shmygareva, Svetlana N. Glushchenko, and Albert I. Agapov. "The current issues of standardization of <i>Aloe arborescens</i> Mill. leaves." Aspirantskiy Vestnik Povolzhiya 21, no. 5-6 (2021): 78–86. http://dx.doi.org/10.55531/2072-2354.2021.21.3.78-86.

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BACKGROUND: Aloe arborescens Mill. leaves contain a whole complex of biologically active compounds (derivatives of anthraquinone, anthrone, pyrone, biopolymers, etc.) and are widely used in medical practice as raw materials for the production of anti-inflammatory, wound healing agents. The presence of anthracene derivatives in the leaves determines the laxative activity of raw plant materials and preparations. It emphasizes the importance of Aloe arborescens preparations for internal use in inflammatory diseases accompanied by constipation and decrease in secretory activity. Another biological

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8

Sobolev, R. V., I. E. Sokolov, N. A. Petrov, V. А. Sarkisyan, and A. A. Kochetkova. "Methods of extraction, separation and identification of cyclic peptides from flaxseed (Linum usitatissimum L.): A review." Food systems 7, no. 4 (2025): 535–42. https://doi.org/10.21323/2618-9771-2024-7-4-535-542.

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Oilseed flax (Linum usitatissimum L.) is a valuable crop characterized by a high content of fats, dietary fiber, protein and various biologically active substances, in particular cyclopeptides. Cyclic peptides are a group of cyclic hydrophobic peptides consisting of eight to ten amino acids with a molecular weight in the range of 950–2300 Da. Flax oil and seeds contain from 0.1 to 0.3% cyclopeptides, which can exhibit antioxidant, anti-inflammatory, immunosuppressive, antihypertensive and antitumor activity. The aim of this review was to systematize and summarize the available literature data

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9

Kotova, Elizaveta O., Alexandra Yu Moiseeva, Zhanna D. Kobalava та ін. "Proinflammatory cytokines IL-6, IL-1β, TNF-α in infective endocarditis". Terapevticheskii arkhiv 96, № 4 (2024): 342–48. http://dx.doi.org/10.26442/00403660.2024.04.202711.

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Aim. To study the features of macrophages in the tissues of resected valves in operated patients with infective endocarditis (IE), their significance and interaction with inflammatory markers to improve the effectiveness of IE diagnosis. Materials and methods. Prospectively the research included 25 adult patients with active IE (Duke criteria 2015) and 24 patients with heart defects without IE, hospitalized in a cardiosurgical hospital in Moscow (2021–2022). A standard laboratory and instrumental examination was carried out for the diagnosis of IE, including etiological diagnosis with microbio

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10

Dijs, Ivo J., Eric van der Windt, Lauri Kaihola, and Klaas van der Borg. "Quantitative Determination by 14C Analysis of the Biological Component in Fuels." Radiocarbon 48, no. 3 (2006): 315–23. http://dx.doi.org/10.1017/s0033822200038777.

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Radiocarbon analysis was performed by liquid scintillation counting (LSC) and accelerator mass spectrometry (AMS) to assess whether the content of biological components in hydrocarbon fuels could be derived. Different fuel mixtures were prepared containing bioethanol, fossil ethanol, and fossil gasoline. The specific 14C activity of these mixtures was obtained from LSC measurements and directly related to the concentration of carbon originating from the bioethanol (biocarbon). The results were checked via standardized carbon dating procedures and AMS. A good linear correlation exists between t

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11

Nam, Anne-Marie, Mathieu Paoli, Vincent Castola, Joseph Casanova, and Ange Bighelli. "Identification and Quantitative Determination of Lignans in Cedrus atlantica Resins using 13C NMR Spectroscopy." Natural Product Communications 6, no. 3 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600316.

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Identification and quantitative determination of individual components of resin collected on the trunk of 28 Cedrus atlantica trees, grown in Corsica, has been carried out using 13C NMR spectroscopy. Eight resin acids bearing either the pimarane or abietane skeleton, two monoterpene hydrocarbons and four oxygenated neutral diterpenes have been identified, as well as three lignans, scarcely found in resins. Three groups could be distinguished within the 28 resin samples. The nine samples of Group I had their composition dominated by diterpene acids (33.7-45.8%), with abietic acid (6.2-18.7%) an

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12

Radeta, Milena, Jasna Novakovic, Milanka Vico-Stevanovic, Slobodanka Simic, and Aleksandar Pirozkov. "Isolation of thymus gland fractions and the determination of their biological activity." Journal of the Serbian Chemical Society 72, no. 3 (2007): 225–34. http://dx.doi.org/10.2298/jsc0703225r.

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A calf thymus extract was prepared and fractionated into lipid and non-lipid fractions. The non-lipid fraction was isolated from the calf thymus extract using the Folch method. The components isolated from the non-lipid fraction were characterized by IR, NMR, biuret and HPLC method. The results of the analyses indicated the presence of peptides. The lipid fraction contained phospholipids, glycolipids and neutral lipids. The biological activity of both the isolated lipid and peptide fractions was determined by the in vivo hemolytic plaques method in Wistar rats with an involuted thymus. The pep

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13

Atul Kumar Singh and Arun Kumar. "Extraction, Characterization, and Biological Activities of Phytochemicals from Terminalia Arjuna (Arjuna) Plant." International Journal for Research Publication and Seminar 15, no. 2 (2024): 210–20. http://dx.doi.org/10.36676/jrps.v15.i2.1410.

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This study focuses on the comprehensive characterization and biological activities of phytochemicals from the bark of Terminalia Arjuna (Arjuna). The bark, known for its medicinal properties, was extracted using methanol and analyzed for its phytochemical profile. The study employed various spectroscopic methods including Fourier transform infrared (FTIR), 1H NMR and 13C NMR spectroscopy. The antioxidant and anti-inflammatory activities were also evaluated while antimicrobial activity was assessed against both Gram-positive and Gram-negative bacteria. Additionally, the study included character

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14

Marinova, Petya, Dimitar Stoitsov, Nikola Burdzhiev, et al. "Investigation of the Complexation Activity of 2,4-Dithiouracil with Au(III) and Cu(II) and Biological Activity of the Newly Formed Complexes." Applied Sciences 14, no. 15 (2024): 6601. http://dx.doi.org/10.3390/app14156601.

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Анотація:

The goal of this study is to synthesize, determine the structure, and examine the antimicrobial properties of novel Cu(II) and Au(III) complexes of 2,4-dithiouracil and its derivatives. These complexes were obtained by mixing aqueous solutions of the corresponding metal salts with the ligand dissolved in DMSO and aqueous NaOH, using a metal-to-ligand ratio of 1:4:2. The structures of the new compounds were analyzed by melting point determination, microwave plasma atomic emission spectrometry (MP-AES) for Cu and Au, inductively coupled plasma optical emission spectrometry (ICP-OES) for S, atten

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15

Adil Hussein Dalaf, Fawzi Hameed Jumaa, and Salwa Abdul-Satar Jabbar. "Synthesis and Characterization of some 2,3-dihydroquinozoline and evaluation of their biological activity." Tikrit Journal of Pure Science 23, no. 8 (2018): 66–76. http://dx.doi.org/10.25130/tjps.v23i8.545.

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This work included the synthesis of azo dye (A1) by the reaction of diazonium salt to benzidine with salicyldehyde at (0-5) oC and synthesis of schiff base (A2-A6) through reaction substituted aromatic amine with aldehyde group in azo compound (A1) in ethanol compounds (A2-A6) and 2,3-dihydroquinozoline derivatives prepared by reaction schiff base with anthranilic acid in ethanol compounds (A7-A11), and characterization by using spectroscopic techniques Uv/Vis, FT-IR, C.H.N. and H1-NMR of some the prepared compounds using DMSO-d6 as a solvent, in addition to melting point and determination a p

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16

Taha, Duha E., Ayad M. R. Raauf, and Karima F. Ali. "Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having." Al Mustansiriyah Journal of Pharmaceutical Sciences 19, no. 4 (2019): 77–88. http://dx.doi.org/10.32947/ajps.v19i4.637.

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New series of Nabumetone containing 5-arylidene-4-thiazolidinones pharmacophore as in compounds 3(a-e) were designed and synthesized by using nabumetone and hydrazinethiocarboamide to synthesize compound (1) (Schiff base), next step  compound (1) will react with chloroacetic acid and anhydrous sodium acetate in order to synthesize compound (2) containing 4-thiazolidinone ring this compound will react with 4-benzaldehyde derivatives in the presence of basic media such as piperidine to form compounds 3(a-e). The structures of new intermediate and final synthesized compounds were dete

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17

Kodchakorn, Kanchanok, Nawarat Viriyakhasem, Tunchanok Wongwichai, and Prachya Kongtawelert. "Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement." Molecules 26, no. 4 (2021): 949. http://dx.doi.org/10.3390/molecules26040949.

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Unapproved ingredients included in herbal medicines and dietary supplements have been detected as adulterated synthetic drugs used for erectile dysfunction. Extraction from a dietary supplement was performed to isolate the compounds by HPLC analysis. The structural characterization was confirmed using mass spectrometry (ESI-TOF/MS and LC-MS/MS), 1H NMR, and 13C NMR spectroscopy techniques. Results identified the thus-obtained compound to be sulfoaildenafil, a thioketone analogue of sildenafil. The biological activities of this active compound have been focused for the first time by the experim

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18

Holota, Serhii. "Synthesis of novel pyrazoline-thiazolidin-4-one hybrids and evaluation their biological activity." Ukr. Bioorg. Acta 2021, Vol. 16, N1 16, no. 1 (2021): 18–24. http://dx.doi.org/10.15407/bioorganica2021.01.018.

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In the present work, the synthesis of pyrazoline-thiazolidin-4-one hybrids and their pharmacological properties are described. The structure of compounds is characterized using 1H, 13C NMR, and LC-MS spectra. The antioxidant (DPPH assay), antimicrobial (Gram-positive bacterium Lactobacillus plantarum, Gram-negative bacterium Escherichia coli, and yeasts Candida albicans, MIC determination), redox (cyclic voltammetry) as well as herbicidal activity (against grass species Agrostis stolonifera) of compounds have been studied. All derivatives have demonstrated radical scavenging activity with IC50

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19

Khalil, Sara L., and Neam H. Saleem. "SYNTHESIS AND CHARACTERIZATION OF FIVE-MEMBERED HETEROCYCLIC COMPOUNDS OF TETRAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY." Chemical Problems 23, no. 3 (2025): 365–74. https://doi.org/10.32737/2221-8688-2025-3-365-374.

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The aim of this study is to synthesize five-membered heterocyclic compounds containing four nitrogen atoms and one carbon atom in their structure. These compounds are known as tetrazoles, derived from 4-aryl-2-amino-1,3-thiazole (4-1), which were synthesized by reacting acetophenone or its derivatives (4-CH3, 3-NO2, 2-Cl) with thiourea in the presence of iodine as a catalyst to initiate the reaction. The amine was used to prepare Schiff bases (5-13) by reacting with acetophenone or its derivatives (4-NO2, 4-Cl, 4-CH3, 2-Cl, 3-NO2). The prepared Schiff bases (5-13) were then used to synthesize

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20

Zykova, Maria V., Konstantin S. Brazovskii, Kristina A. Bratishko, et al. "Quantitative Structure-Activity Relationship, Ontology-Based Model of the Antioxidant and Cell Protective Activity of Peat Humic Acids." Polymers 14, no. 16 (2022): 3293. http://dx.doi.org/10.3390/polym14163293.

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Peat humic acids are well known for their wide range of biological effects which can be attributed to the complex chemical structure of naturally occurring humic substances. One of the promising tools is an ontology-based quantitative analysis of the relationship between physical and chemical parameters describing a chemical structure of peat humic acids and their biological activity. This article demonstrates the feasibility of such an approach to estimate the antioxidant and cell protective properties of the peat humic acids. The structural parameters of the peat humic acids were studied by

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21

Scotti, Luciana, Mariane Balerine Fernandes, Eric Muramatsu, et al. "13C NMR spectral data and molecular descriptors to predict the antioxidant activity of flavonoids." Brazilian Journal of Pharmaceutical Sciences 47, no. 2 (2011): 241–49. http://dx.doi.org/10.1590/s1984-82502011000200005.

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Tissue damage due to oxidative stress is directly linked to development of many, if not all, human morbidity factors and chronic diseases. In this context, the search for dietary natural occurring molecules with antioxidant activity, such as flavonoids, has become essential. In this study, we investigated a set of 41 flavonoids (23 flavones and 18 flavonols) analyzing their structures and biological antioxidant activity. The experimental data were submitted to a QSAR (quantitative structure-activity relationships) study. NMR 13C data were used to perform a Kohonen self-organizing map study, an

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22

Hiba Ibrahim Abdulla AL-Joubory and Khalid Mohamad Motny Al-janaby. "Synthesis, Characterization and Biological Activity Study of New Compounds Tetrazole Derivatives Azo-Schiff Base." journal of the college of basic education 25, no. 103 (2019): 68–89. http://dx.doi.org/10.35950/cbej.v25i103.4547.

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Анотація:

This work included synthesis of azo dye (H1) by the reaction of diazonium salt to sulfacetamide with 4-hydroxy benzaldehyde at (0-5) oC and synthesis of schiff base (H2-H6) through reaction substituted aromatic amine (aniline, 4-nitro aniline, 4-chloro aniline, 4-amino benzoic acid and phenyl hydrazine) with aldehyde group in azo compound (H1) in ethanol compounds (H2-H6) and tetrazole derivatives prepared by reaction schiff base with sodium azide in ethanol compounds (H7-H11) and characterization by using spectroscopic techniques Uv/Vis, FT-IR, C.H.N. and H1-NMR of some the prepared compounds

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23

Kouakou, Yobouet Ines, Roukayatou Omorou, Ibrahim Bin Said, et al. "Assessment of quantitative and semi-quantitative biological test methods of artesunate in vitro." Parasite 29 (2022): 18. http://dx.doi.org/10.1051/parasite/2022019.

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Artesunate is the current most potent antimalarial drug widely used for the treatment of malaria. Considering the emergence of artemisinin resistance, several situations may require a simple method for artesunate quantification. We thus developed a quantitative and a semi-quantitative biological method for the determination of artesunate in liquid samples. The tests are based on the measurement of samples’ antimalarial activity on Plasmodium falciparum 3D7 using a modified SYBR Green I drug susceptibility test. For the quantitative test, we established a standard curve that resulted from a dos

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24

Pedras, M. Soledade C., Yang Yu, Jun Liu, and Yudelsy A. Tandron-Moya. "Metabolites Produced by the Phytopathogenic Fungus Rhizoctonia solani: Isolation, Chemical Structure Determination, Syntheses and Bioactivity." Zeitschrift für Naturforschung C 60, no. 9-10 (2005): 717–22. http://dx.doi.org/10.1515/znc-2005-9-1010.

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Abstract The isolation, structure determination, syntheses and biological activity of Nb-acetyltryptamine and three proline containing dioxopiperazines, cyclo(S-Pro-S-Leu) (2), cyclo(S-Pro- S-Ile) (3), and cyclo(S-Pro-S-Val) (4), from cultures of Rhizoctonia solani Kuhn are reported here for the first time. Despite the small amounts isolated, the absolute stereochemistry of these naturally occurring dioxopiperazines was established by 1H NMR using for the first time the chiral solvating agent (R)-(D)-2,2,2-trifluoro-1-(9-anthryl)ethanol.

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25

Podolak, Irma, Paweł Żmudzki, Paulina Koczurkiewicz, Marta Michalik, Paweł Zajdel, and Agnieszka Galanty. "Minor Triterpene Saponins from Underground Parts of Lysimachia thyrsiflora: Structure elucidation, LC-ESI-MS/MS Quantification, and Biological Activity." Natural Product Communications 8, no. 12 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801208.

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Анотація:

Two minor triterpene saponins, one previously not reported, were isolated from the underground parts of Lysimachia thyrsiflora L. The structures were determined based on a combination of one- and two-dimensional NMR techniques, and mass spectrometry, as 30- O-β-D-glucopyranosyl-3β,16α,30-trihydroxy-olean-12-en-28-yl acetate 3- O-β-D-glucopyranosyl-(1→4)- O-[β-D-glucopyranosyl-(1→2)-]- O-α-L-arabinopyranoside (denoted as thyrsiloside A), and davuricoside L. Quantitative determination of these two compounds, along with other saponins present in L. thyrsiflora underground parts, was performed by

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26

ROMAGNOLI, Silvia, Raffaella UGOLINI, Federico FOGOLARI, et al. "NMR structural determination of viscotoxin A3 from Viscum album L." Biochemical Journal 350, no. 2 (2000): 569–77. http://dx.doi.org/10.1042/bj3500569.

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Анотація:

The high-resolution three-dimensional structure of the plant toxin viscotoxin A3, from Viscum album L., has been determined in solution by 1H NMR spectroscopy at pH 3.6 and 12°C (the structure has been deposited in the Protein Data Bank under the id. code 1ED0). Experimentally derived restraints including 734 interproton distances from nuclear Overhauser effect measurements, 22 hydrogen bonds, 32ϕ angle restraints from J coupling measurements, together with three disulphide bridge constraints were used as input in restrained molecular dynamics, followed by minimization, using DYANA and Disco

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27

Aini, Kurratul, Elfita Elfita, Hary Widjajanti, and Arum Setiawan. "Bioactivity of Endophytic Fungi Isolated from Branch of Jambu Mawar (Syzygium jambos (L.) Alston)." Molekul 18, no. 1 (2023): 59. http://dx.doi.org/10.20884/1.jm.2023.18.1.5931.

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Анотація:

Endophytic fungi isolated from medicinal plants have high diversity and the secondary metabolites produced have biological activity. Endophytic fungi isolated from medicinal plants have been the subject of many studies on their diversity and biological activity, one of which is jambu mawar (Syzygium jambos (L.) Alston). S. jambos has long been used as a traditional medicine to treat infections caused by pathogenic bacteria in many parts of the world, including South Sumatra. This study purposed to explore the diversity of endophytic fungi isolated from the branches of S. jambos, the antibacter

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28

Sonawane, Vikas D., Raghunath B. Bhosale, Gajanan S. Rashinkar, and Kailas D. Kailas D. "GREEN SYNTHESIS AND BIOLOGICAL SCREENING OF IMIDAZO [2,1-B] THIAZOLE PYRIMIDINES AS POTENT ANTI-BACTERIAL AGENTS." YMER Digital 21, no. 07 (2022): 280–95. http://dx.doi.org/10.37896/ymer21.07/21.

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Анотація:

A series of Imidazo[2,1-b]thiazole pyrmidine derivatives (3a-g-) were designed, synthesized from imidazo[2,1-b]thiazole chalcone derivatives. (2a-g) and Urea in PEG-400 and evaluated for their anti-bacterial potency. Characterization of newly synthesized compounds was done using IR and 1H NMR and Mass spectroscopy. Further Imidazo [2,1-b]thiazole pyrimidine derivatives were subjected to check their anti-bacterial activities against four different strains, viz two Gram +ve bacteria Staphylococcus aureus & Bacillus subtilis and two Gram -ve bacteria Escherichia coli & Pseudomonas aerugin

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Bhatt, Keyur D. "Synthesis, Characterization and Biological Screening of Schiff bases derived from 4, 6-difluoro-2-amino Benzothiazole." Medicinal and Analytical Chemistry International Journal 4, no. 1 (2020): 1–7. http://dx.doi.org/10.23880/macij-16000157.

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Novel benzothiazole Schiff bases namely N-(4-chlorobenzylidene)-4,6-difluorobenzothiazole-2-amine; 4,6-difluoro-N-(4- nitrobenzylidene)benzothiazol-2-amine and N-((1H-indol-3-yl)methylene)-4,6-difluorobenzothiazole-2-amine have been synthesized from condensation reaction of 4,6-difluoro-2-amino benzothiazole with different aromatic aldehydes like 4-chlorobenzaldehyde, 4-nitrobenzaldehyde and 1H-indole-3-cardaldehyde. The structures of all the compounds were characterized by elemental analysis, FT-IR, Mass and 1 H-NMR spectroscopy. Schiff bases have been screened for antimicrobial activity agai

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30

Gotina, O. O., I. V. Vasiltsova, and Yu I. Koval. "Biological and antioxidant activity of calendula officinalis." Innovations and Food Safety, no. 1 (April 8, 2025): 72–80. https://doi.org/10.31677/2311-0651-2025-47-1-72-80.

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The article presents the results of studying the biological and antioxidant activity of Calendula officinalis. For this purpose, quantitative determination of some groups of biologically active substances in the pharmaceutical raw material of calendula officinalis flowers produced by JSC Krasnogorskleksredstva (PharmaTsvet) was performed using spectrophotometric and titrimetric methods. The analysis established the content of tannins - 4.10%, ascorbic acid - 19.80 mg%, carotenoids - 1.70 mg%, chlorophyll - 1.10 mg%, flavonoids - 0.86%. To determine the antioxidant activity, aqueous and aqueous

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31

Zhao, Boxuan, Zhijian Li, Zhi Wang, Yunbo Zhao, and Yimin Xie. "Preparation of lignin-like polymers by dehydrogenation of lignin precursors and structure-activity relationships of the resulting polymers against live cancer HepG2 cells." BioResources 20, no. 2 (2025): 2904–21. https://doi.org/10.15376/biores.20.2.2904-2921.

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Lignin can be used as a natural anticancer drug because of its potential biological activity and low cytotoxicity. This research focuses on oligomeric dehydrogenation polymers (DHPs) of lignin. The lignin precursor coniferin was used to yield Zulaufverfahren dehydrogenation polymers (ZL-DHPs) and Zutropfverfahren dehydropolymers (ZT-DHPs) catalyzed by mixed enzymes. The 13C-NMR determination showed that the DHPs obtained were similar to natural lignin, and ZL-DHP had a slightly higher β-5 content than ZT-DHP. ZL-DHPs and ZT-DHPs were subjected to organic solvent extraction with different polar

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32

Хадарцев, A. Khadartsev, Платонов, et al. "Chemical Composition and Biological Activity of Sapropel from the Lake Glubokoe (Tatarstan)." Journal of New Medical Technologies 21, no. 3 (2014): 199–204. http://dx.doi.org/10.12737/5935.

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Анотація:

Detailed information about qualitative and quantitative composition of individual components of the group sapropel from the lake Glubokoe (Tatarstan), as well as on the biological activity of different sapropel preparations were obtained by means of the methods Fourier spectroscopy, UV/Vis, NMR spectroscopy, gas chromatography-mass spectrometry, preparative Thin-layer chro-matography (TLC) with witnesses, elemental and functional analysis. Sequential scheme of extraction, acid-alkaline hydrolysis, preparative TLC source of sapropel and individual components of organic matter was developed. Ami

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33

Verma, Krishan Kumar, Umesh Kumar Singh, and Jainendra Jain. "Design, Synthesis and Biological Activity of Some 4, 5-Disubstituted-2, 4- Dihydro-3H-1, 2, 4- Triazole-3-Thione Derivatives." Central Nervous System Agents in Medicinal Chemistry 19, no. 3 (2019): 197–205. http://dx.doi.org/10.2174/1871524919666190722144424.

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Background: In the present study, 4, 5-disubstituted triazol-3-thione derivatives were synthesized and evaluated for anticonvulsant activity along with neurotoxicity determination. Materials and Methods: The synthesized compounds were characterized using FTIR, 1H-NMR and MS. The anticonvulsant activity was assessed by Maximal Electroshock (MES) test and subcutaneous Pentylenetetrazole (scPTZ) tests and neurotoxicity was assessed by rotarod test. Docking was also performed to study the interactions of compounds with LYS329 residue of gamma amino butyric acid aminotransferase (GABA-AT) using Aut

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34

Brandão, Deysiane Oliveira, Geovani Pereira Guimarães, Ravely Lucena Santos, et al. "Model Analytical Development for Physical, Chemical, and Biological Characterization ofMomordica charantiaVegetable Drug." Journal of Analytical Methods in Chemistry 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/7528297.

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Momordica charantiais a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. Analytical methods have been used to aid in the characterization of compounds derived from plant drug extracts and their products. This paper developed a methodological model to evaluate the integrity of the vegetable drugM. charantiain different particle sizes, using different analytical methods.M. charantiawas collected in the semiarid region of Paraíba, Brazil. The herb

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35

Mohammad Moatz Ghazi Shollar, Joumaa Merza, Thanaa Shriteh, Mohammad Moatz Ghazi Shollar, Joumaa Merza, Thanaa Shriteh. "Synthesis of the new derivative 1- Diphenylamine Enamine Ascorbic Acid, and study of its biological activity: اصطناع المشتق الجديد 1- ثنائي فينيل إينامين حمض الأسكوربيك ودراسة نشاطه البيولوجي". Journal of natural sciences, life and applied sciences 5, № 2 (2021): 128–13. http://dx.doi.org/10.26389/ajsrp.s260421.

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The new enamine [1- Diphenyl enamine ascorbic acid] has been prepared according to two methods: The first method was “The reaction between ascorbic acid and diphenylamine” has been done directly, however the yield was relatively low. The second method was “the reaction between ascorbic acid and diphenylamine” which has been carried out through three steps: In the first step, the hydroxyl groups in (5, 6) position have been protected using the acetone, in the second step, the hydroxyl groups in (2, 3) position have been protected using iodide methyl. The obtained compound (5, 6-dioxolan-2, 3-me

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36

Lane, Andrew N., Timothy L. Scott, Juan Zhu, et al. "Abstract 2324: Small-scale microwave-assisted acid hydrolysis method for glycogen determination and turnover in tumors using Stable Isotope Resolved Metabolomics." Cancer Research 82, no. 12_Supplement (2022): 2324. http://dx.doi.org/10.1158/1538-7445.am2022-2324.

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Abstract Introduction: Glycogen is a readily deployed intracellular energy storage macromolecule composed of branched chains of glucose. Although glycogen primarily occurs in the liver and muscle, it can be found in most tissues throughout the body, and its metabolism has been shown to be important in cancers and immune cells. Robust analysis of glycogen turnover requires stable isotope tracing plus a reliable means of quantifying total and labeled glycogen derived from precursors such as 13C6-glucose. Current methods for analyzing glycogen are time- and sample-consuming, at best semi-quantita

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37

Béni, Zoltán, Miklós Dékány, András Sárközy, et al. "Triterpenes and Phenolic Compounds from the Fungus Fuscoporia torulosa: Isolation, Structure Determination and Biological Activity." Molecules 26, no. 6 (2021): 1657. http://dx.doi.org/10.3390/molecules26061657.

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Investigation of the methanol extract of the poroid fungus Fuscoporia torulosa resulted in the isolation of a novel triterpene, fuscoporic acid (1), together with inoscavin A and its previously undescribed Z isomer (2 and 3), 3,4-dihydroxy-benzaldehide (4), osmundacetone (5), senexdiolic acid (6), natalic acid (7), and ergosta-7,22-diene-3-one (8). The structures of fungal compounds were determined on the basis of NMR and MS spectroscopic analyses, as well as molecular modeling studies. Compounds 1, 6–8 were examined for their antibacterial properties on resistant clinical isolates, and cytoto

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38

Samukha, Vadym, Francesca Fantasma, Gilda D’Urso, et al. "NMR Metabolomics and Chemometrics of Commercial Varieties of Phaseolus vulgaris L. Seeds from Italy and In Vitro Antioxidant and Antifungal Activity." Plants 13, no. 2 (2024): 227. http://dx.doi.org/10.3390/plants13020227.

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The metabolite fingerprinting of four Italian commercial bean seed cultivars, i.e., Phaseolus Cannellino (PCANN), Controne (PCON), Vellutina (PVEL), and Occhio Nero (PON), were investigated by Nuclear Magnetic Resonance (NMR) spectroscopy and multivariate data analysis. The hydroalcoholic and organic extract analysis disclosed more than 32 metabolites from various classes, i.e., carbohydrates, amino acids, organic acids, nucleosides, alkaloids, and fatty acids. PVEL, PCON, and PCANN varieties displayed similar chemical profiles, albeit with somewhat different quantitative results. The PON meta

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39

Parys, Wioletta, Małgorzata Dołowy, and Alina Pyka-Pająk. "Significance of Chromatographic Techniques in Pharmaceutical Analysis." Processes 10, no. 1 (2022): 172. http://dx.doi.org/10.3390/pr10010172.

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This work presents an overview of the modern approaches embracing advanced equipment and validation parameters of both liquid and gas chromatography techniques, including thin-layer chromatography (TLC), column liquid chromatography (CLC), and gas chromatography (GC), suitable for the identification and quantitative determination of various bioactive compounds occurring in pharmaceutical products and medicinal plants in the time from 2020 to 2021 (November). This review confirmed that HPLC is an incredibly universal tool, especially when combined with different detectors, such as UV-Visible sp

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40

Alanazi, Samyah. "Antineoplastic and Antitrypanosomal Properties of Propolis from Tetragonula biroi Friese." Molecules 27, no. 21 (2022): 7463. http://dx.doi.org/10.3390/molecules27217463.

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Propolis, popularly known as bee glue, is a resinous, sticky substance produced by different bee species across the globe. Studies on the biological properties of propolis from the Philippines are rare. Hence, the current study aims at the chemical characterization of propolis produced by the stingless bees Tetragonula biroi Friese from the Philippines and to investigate its antitrypanosomal and anticancer properties. The determination of the chemical composition and characterization of propolis samples was achieved using liquid chromatography–mass spectrometry (LC-MS), -high-performance liqui

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41

Amosova, A. A., E. A. Amosov, A. N. Sukhonosova, and A. Yu Churkina. "COMPARATIVE ANALYSIS OF METHODS FOR ASSESSING OILY SOLID WASTE ENVIRONMENTAL HAZARD." Izvestiya of Samara Scientific Center of the Russian Academy of Sciences 23, no. 5 (2021): 19–24. http://dx.doi.org/10.37313/1990-5378-2021-23-5-19-24.

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The article is devoted to an actual problem of applied ecology – reliable determination of hazard class of oily solid waste, formation of which is significant and contributes greatly to the overall level of negative impact on the environment of oil producing and oil refining enterprises. Comparison of determination of an oily solid waste chemical composition with the results of hazard classes determination by computational and experimental methods has revealed a number of fundamental problems. Their solution requires changing scientific and methodological approaches to methods of determining e

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42

Ferrante, Laura, Kashif Rajpoot, Mark Jeeves, and Christian Ludwig. "Automated analysis for multiplet identification from ultra-high resolution 2D-1H,13C-HSQC NMR spectra." Wellcome Open Research 7 (October 14, 2022): 262. http://dx.doi.org/10.12688/wellcomeopenres.18248.1.

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Background: Metabolism is essential for cell survival and proliferation. A deep understanding of the metabolic network and its regulatory processes is often vital to understand and overcome disease. Stable isotope tracing of metabolism using nuclear magnetic resonance (NMR) and mass spectrometry (MS) is a powerful tool to derive mechanistic information of metabolic network activity. However, to retrieve meaningful information, automated tools are urgently needed to analyse these complex spectra and eliminate the bias introduced by manual analysis. Here, we present a data-driven algorithm to au

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43

Ferrante, Laura, Kashif Rajpoot, Mark Jeeves, and Christian Ludwig. "Automated analysis for multiplet identification from ultra-high resolution 2D-1H,13C-HSQC NMR spectra." Wellcome Open Research 7 (May 19, 2023): 262. http://dx.doi.org/10.12688/wellcomeopenres.18248.2.

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Анотація:

Background: Metabolism is essential for cell survival and proliferation. A deep understanding of the metabolic network and its regulatory processes is often vital to understand and overcome disease. Stable isotope tracing of metabolism using nuclear magnetic resonance (NMR) and mass spectrometry (MS) is a powerful tool to derive mechanistic information of metabolic network activity. However, to retrieve meaningful information, automated tools are urgently needed to analyse these complex spectra and eliminate the bias introduced by manual analysis. Here, we present a data-driven algorithm to au

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44

Alpan, A. Selcen, H. Semih Gunes, and Zeki Topcu. "1H-Benzimidazole derivatives as mammalian DNA topoisomerase I inhibitors." Acta Biochimica Polonica 54, no. 3 (2007): 561–65. http://dx.doi.org/10.18388/abp.2007_3229.

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Benzimidazole is one of the most important heterocyclic groups manifesting various biological properties, such as antibacterial, antifungal, antimicrobial, antiprotozoal and antihelmintic activities. Several benzimidazole derivatives are also active as inhibitors of type I DNA topoisomerases. In this study, three 1H-benzimidazole derivatives with different electronic characteristics at position 5-, namely 5-chloro-4-(1H-benzimidazole-2-yl)phenol (Cpd I), 5-methyl-4-(1H-benzimidazole-2-yl)phenol (Cpd II) and 4-(1H-benzimidazole-2-yl)phenol (Cpd III), were synthesized and evaluated for their eff

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45

Mathapati, P. S., S. A. Durgad, K. C. Singh, and S. D. Bhinge. "SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF BENZIMIDAZOLE DERIVATIVES." INDIAN DRUGS 49, no. 02 (2012): 17–25. http://dx.doi.org/10.53879/id.49.02.p0017.

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In the present study, the objective is to synthesize novel compounds from the benzimidazole moiety,recognized for its various biological potentials. Chalcone being a very good synthon was utilized to combine with the benzimidazole moiety to design agents with significant antimycobacterial activity. Benzimidazole is formed when o-phenylene diamine is heated with organic acid i.e. formic acid; in presence of strong alkali sodium hydroxide it will gives benzimidazole. Benzimidazole was acetylated with acetyl chloride, the intermediate substituted chalcones were synthesized from acetylated benzimi

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46

Dietzgen, Ralf G., Evamarie Sander, Jürgen Christner, and Günther Jung. "Examination of a New Cross-Linker in Monoclonal Antibody Reaction Against the C-Terminus of Tobacco Mosaic Virus Coat Protein." Zeitschrift für Naturforschung B 42, no. 4 (1987): 441–53. http://dx.doi.org/10.1515/znb-1987-0410.

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The C-terminal tetrapeptide Gly-Pro-Ala-Thr of TMV coat protein was linked to poly- (L-lysine) of 37,300 and 80,000 daltons and to human serum albumin using different ratios of tetrapeptide to carrier. The new hydrazidosuccinyl HSc cross-linker effected the specific amino terminal attachment of the tetrapeptide by azide coupling. The synthetic peptide and its conjugates were controlled by various methods including 13C NMR and CD. Using a conjugate containing 74 tetrapeptide residues linked to poly(L-lysine) of 80,000 daltons for screening of monoclonal antibody by ELISA, 5.8 fmol of peptide we

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47

Oyarce, Jocelyn, Vanessa Aitken, César González та ін. "Synthesis and Structural Determination of New Brassinosteroid 24-Nor-5α-Cholane Type Analogs". Molecules 24, № 24 (2019): 4612. http://dx.doi.org/10.3390/molecules24244612.

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Natural brassinosteroids possess a 22R, 23R configuration that appears essential for biological activity. It is, therefore, interesting to elucidate if the activity of brassinosteroids with a short side chain depends on the C22 configuration. Herein, we describe the synthesis of new brassinosteroids analogs with 24-norcholane type of side chain and R configuration at C22. The initial reaction is the dihydroxylation of a terminal olefin that leads to S/R epimers. Three different methods were tested in order to evaluate the obtained S/R ratio and the reaction yields. The results indicate that Up

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48

Al-Rubaye, Baidaa. "Synthesis, Structural Investigation and Biological Activity of a Heterocyclic Schiff-Base Ligand and Its Coordination Complexes." Wasit Journal for Pure sciences 3, no. 4 (2024): 319–27. https://doi.org/10.31185/wjps.570.

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Анотація:

This study reports the formation, characterisation and biological evaluation of a Schiff base ligand and its corresponding metal complexes. The Schiff base ligand (HL) was prepared through a condensation reaction involving isonicotinohydrazide and N'-((1R,2R,4R,5S, E)-2,4-bis(4-chlorophenyl)-3-azabi cyclo[3.3.1]nonan-9-ylidene) isonicotinohydrazide (M) in EtOH solvent and (3-5) drops of conc. HCl. The interaction of HL with selected metal chlorides including Mn(+2), Co(+2), Ni(+2), Cu(+2) and Zn(+2) in a 2:1 (L:M) mole ratio resulted in the synthesis of complexes with the general formula [M(HL

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49

Nikolaichuk, Hanna, Marek Studziński, Marek Stankevič, and Irena M. Choma. "Qualitative and Quantitative Evaluation of Rosavin, Salidroside, and p-Tyrosol in Artic Root Products via TLC-Screening, HPLC-DAD, and NMR Spectroscopy." Molecules 27, no. 23 (2022): 8299. http://dx.doi.org/10.3390/molecules27238299.

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Artic root is a well-known plant adaptogen with multipotential pharmacological properties. Thin-layer chromatography (TLC)—screening followed by diode-array high-performance liquid chromatography and nuclear magnetic resonance spectroscopy proved to be a reliable and convenient method for the simultaneous determination of the quality of various herbal raw materials and supplements. This combination allowed for comparing and differentiating arctic root samples as well as defining their authenticity. The study provided information on the chemical and biological properties of the seven chosen sam

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50

Kotalwar, Sanjay Shriramrao, Rajendra Prahlad Phase, Amol Diliprao Kale, Gautam Prabhakar Sadawarte, and Vasant Bhagwan Jagrut. "An efficient synthesis, anticancer and antimycobacterial activities of new substituted pyridine based azomethine derivatives." European Journal of Chemistry 16, no. 2 (2025): 129–35. https://doi.org/10.5155/eurjchem.16.2.129-135.2621.

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Анотація:

Pyridine, a fundamental heterocyclic scaffold, is a key structural component in numerous biologically active molecules, including alkaloids, vitamins B3 and B6, coenzymes, and other natural products. Its significance in medicinal chemistry arises from its versatile physicochemical properties, such as its capacity to form hydrogen bonds, its high water solubility, and its chemical stability. In this study, a series of substituted pyridine-based analogues (3a-h) were synthesized and their structural elucidation was performed using various spectroscopic techniques. These derivatives incorporate a

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