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Добірка наукової літератури з теми "QUERCETIN ANALOGUES"

Автор: Grafiati

Опубліковано: 26 жовтня 2023

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Статті в журналах з теми "QUERCETIN ANALOGUES"

1

Otieno, Filex, and Richard Kagia. "Virtual screening for chemical analogues similar to phytochemicals that inhibit aldose reductase in the development of diabetic microvascular complications." F1000Research 12 (March 21, 2023): 314. http://dx.doi.org/10.12688/f1000research.129663.1.

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Background: The polyol pathway contributes to the development of diabetic complications but can be inhibited by plant phytochemicals. This study aimed at assessing analogs of specific flavonoids that delay onset of microvascular complications with better pharmacokinetic and toxicology profiles. Methods: An in silico study design was employed. The phytochemicals luteolin and quercetin were selected. Analogs were obtained from ZINC database and prepared using Avogadro software. Docking analysis was done using AutoDock Vina embedded in Chimera. Ligand enzyme interaction was carried out using Biov

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2

Pardo, Antonelle, Thomas Josse, Laetitia Mespouille, Bertrand Blankert, Philippe Dubois, and Pierre Duez. "Synthesis of Quercetin-imprinted Polymer Spherical Particles with Improved Ability to Capture Quercetin Analogues." Phytochemical Analysis 28, no. 4 (2017): 289–96. http://dx.doi.org/10.1002/pca.2674.

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3

Biler, Michal, David Biedermann, Kateřina Valentová, Vladimír Křen, and Martin Kubala. "Quercetin and its analogues: optical and acido–basic properties." Phys. Chem. Chem. Phys. 19, no. 39 (2017): 26870–79. http://dx.doi.org/10.1039/c7cp03845c.

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4

Imai, Kohei, Ikuo Nakanishi, Kei Ohkubo, et al. "Synthesis of methylated quercetin analogues for enhancement of radical-scavenging activity." RSC Advances 7, no. 29 (2017): 17968–79. http://dx.doi.org/10.1039/c7ra02329d.

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5

Duan, Yu, Na Sun, Min Xue, Xiaolan Wang, and Hu Yang. "Synthesis of regioselectively acylated quercetin analogues with improved antiplatelet activity." Molecular Medicine Reports 16, no. 6 (2017): 9735–40. http://dx.doi.org/10.3892/mmr.2017.7781.

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6

Fernández-Aparicio, Mónica, Marco Masi, Alessio Cimmino, Susana Vilariño, and Antonio Evidente. "Allelopathic Effect of Quercetin, a Flavonoid from Fagopyrum esculentum Roots in the Radicle Growth of Phelipanche ramosa: Quercetin Natural and Semisynthetic Analogues Were Used for a Structure-Activity Relationship Investigation." Plants 10, no. 3 (2021): 543. http://dx.doi.org/10.3390/plants10030543.

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Allelopathic potential of buckwheat roots on the radicle growth of the broomrape weed species Orobanche cumana and Phelipanche ramosa was studied. Buckwheat root exudates induced a significant growth inhibition in P. ramosa radicles but radicles of O. cumana were not affected. Among the metabolites present in the root organic extract we identified the flavonol quercetin and the stilbene p-coumaric acid methyl ester with only quercetin showing inhibitory effect on P. ramosa. The activity of quercetin was compared with other two similar flavanoids, the flavone apigenin and the dihydroflavanol 3-

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7

Litvin, V. A., and R. A. Njoh. "Quercetin as a precursor in the synthesis of analogues of fulvic acids and their antibacterial properties." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 2 (March 2021): 56–64. http://dx.doi.org/10.32434/0321-4095-2021-135-2-56-64.

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A simple, fast and effective method for producing synthetic substances with properties similar to natural humic substances has been proposed. The synthesis method is based on the oxidation of quercetin by molecular oxygen in an alkaline medium, followed by conversion to the acid form by passing through a cation exchange column. Study of elemental and functional compositions, spectral properties (UV/Vis and IR range) and redox characteristics allowed qualifying the resulting product as a synthetic fulvic acid. The enhanced antibacterial properties of the obtained synthetic product were establis

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8

Atala, Elias, Jocelyn Fuentes, Maria Jose Wehrhahn, and Hernan Speisky. "Oxidation of Quercetin and Its Structural Analogues Differentially Affects Its Antioxidant Properties." Free Radical Biology and Medicine 100 (November 2016): S93. http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.231.

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9

Nayak, Yogendra, Venkatachalam Hillemane, Vijay Kumar Daroji, B. S. Jayashree, and M. K. Unnikrishnan. "Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/854267.

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Benzopyrones are proven antidiabetic drug candidate in diabetic drug discovery. In this view novel synthetic benzopyrone analogues were selected for testing in experimental diabetes. Type 2 diabetes (T2D) was induced in Wistar rats by streptozotocin (60 mg/kg, i.p.) followed by nicotinamide (120 mg/kg i.p.). Rats having fasting blood glucose (FBG) >200 mg/dL, 7 days after T2D-induction, are selected for the study. Test compounds and standard treatment were continued for 15 days. FBG, oral glucose tolerance test (OGTT), and insulin tolerance test (ITT) were determined on 21st day after induc

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10

Primikyri, Alexandra, Eleftheria Hatzimichael, Evdoxia Karali, et al. "Decoding The BH3-Mimetic Pro-Apoptotic Activity Of Quercetin In Jurkat Cells." Blood 122, no. 21 (2013): 1672. http://dx.doi.org/10.1182/blood.v122.21.1672.1672.

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Abstract Deregulation of apoptosis contributes largely to the pathogenesis of lymphoid neoplasms allowing the expansion of cell clones that develop resistance to drug-induced cell death. Therefore, subverting inherent resistance to apoptosis is a very challenging therapeutic issue and developing small molecules that can mimic the BH3 domain of the pro-apoptotic Bcl-2 family proteins appears to offer such potentials. Natural products, a rich source of compounds with BH3 mimetic activity, make a sound basis for such an approach. Quercetin, a natural polyphenol, has drawn much attention because i

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