Готові списки джерел за темами / Randomised controlled crossover trial

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Добірка наукової літератури з теми "Randomised controlled crossover trial"

Автор: Grafiati

Опубліковано: 10 січня 2023

Оновлено: 28 січня 2023

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Статті в журналах з теми "Randomised controlled crossover trial"

Investigators, *The SuDDICU, Laurent Billot, Brian Cuthbertson, Anthony Gordon, Farah Al-Beidh, Maryam Correa, Joshua Davis, et al. "Protocol summary and statistical analysis plan for the Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU) crossover, cluster randomised controlled trial." Critical Care and Resuscitation 23, no. 2 (June 7, 2021): 183–93. http://dx.doi.org/10.51893/2021.2.oa5.

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Background: It is unclear whether the use of selective decontamination of the digestive tract (SDD) improves outcomes in ventilated patients in intensive care units (ICUs) and whether SDD is associated with the development of antibiotic resistance. Objective: To describe the study protocol and statistical analysis plan for the Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU) trial. Design, setting, participants and intervention: SuDDICU is an international, crossover, cluster randomised controlled trial of mechanically ventilated patients in ICUs using two 12-month trial periods. For each period, participating ICUs will implement SDD plus standard care or standard care alone. The SuDDICU drug intervention is an oral paste and gastric suspension of three antibiotics combined with a 4-day course of intravenous antibiotics. Observational ecological assessments will be conducted during five surveillance periods. The trial will be conducted in 19 ICUs in Australia and ten ICUs in Canada and the United Kingdom, and will recruit 15 000–17 000 patients. Recruitment commenced in Australia in 2017. Main outcome measures: The primary outcome is all-cause hospital mortality. Secondary outcomes include: duration of ventilation, ICU stay and hospital stay; incidence of new antibiotic-resistant organisms during the index ICU admission; changes in antibiotic-resistant organism rates; incidence of new Clostridioides difficile infections; and total use of antibiotics. Results and conclusions: SuDDICU will determine whether the use of SDD plus standard care is associated with a reduction in hospital mortality in ventilated ICU patients compared with standard care alone. It will also quantify the impact of the use of SDD on the development of antibiotic resistance. Trial registration: Australian New Zealand Clinical Trials Registry (ACTRN12615000411549) and ClinicalTrials.gov (NCT02389036).

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Kaushal, Prachi, Sherna F. Adenwalla, Courtney J. Lightfoot, Daniel S. March, Laura J. Gray, and James O. Burton. "Evaluation of the design, conduct and reporting of randomised controlled trials in the haemodialysis population: a scoping review and interview study." BMJ Open 12, no. 3 (March 2022): e058368. http://dx.doi.org/10.1136/bmjopen-2021-058368.

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BackgroundFewer trials are conducted in nephrology than any other specialty, often failing to recruit to target, resulting in unclear evidence affecting translation to clinical practice. This mixed-methods study aims to provide guidance for designing and reporting future randomised controlled trials (RCTs) in the haemodialysis population.MethodA scoping review was conducted. Five databases (MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov) were searched for RCTs published between 2013 and 2019 involving prevalent adult haemodialysis patients. Reporting of sample size, recruitment, retention and statistical significance of primary outcome were assessed. Face-to-face semistructured interviews were conducted with individuals from a single centre during dialysis sessions. Interviews were analysed thematically.ResultsOf 786 RCTs identified, 636 (80.9%) were parallel-group, 139 (17.7%) were crossover and 11 (1.4%) were cluster (including one stepped-wedge) design. Sample size justification was reported in 73.1%, 53.8% and 45.5% of parallel-group, crossover and cluster trials, respectively.Target recruitment was achieved by 45.5% of cluster, 53.8% of crossover and 57.7% of parallel-group trials with patient retention at 75.6%, 83.1% and 87.8%, respectively. Primary outcome reached statistical significance in 81.8% of cluster trials, 69.2% of parallel-group and 38.5% of crossover trials.Themes identified from individual interviews: perceptions of the convenience of trial participation; group allocation; perceptions of the benefits and adverse effects of taking part in clinical trials.ConclusionThe recruitment and reporting of RCTs involving people on haemodialysis could be improved. Involvement of all stakeholders and especially participants in the trial design process may address issues around participant burden and ultimately improve the evidence base for clinical practice.

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Dalbeth, N., S. Wong, G. D. Gamble, A. Horne, B. Mason, B. Pool, L. Fairbanks, et al. "Acute effect of milk on serum urate concentrations: a randomised controlled crossover trial." Annals of the Rheumatic Diseases 69, no. 9 (May 14, 2010): 1677–82. http://dx.doi.org/10.1136/ard.2009.124230.

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Lenhardt, R. "Local warming and insertion of peripheral venous cannulas: single blinded prospective randomised controlled trial and single blinded randomised crossover trial." BMJ 325, no. 7361 (August 24, 2002): 409. http://dx.doi.org/10.1136/bmj.325.7361.409.

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de Ruijter, Jessica, Marlies J. Valstar, Magdalena Narajczyk, Grzegorz Wegrzyn, Wim Kulik, Lodewijk IJlst, Tom Wagemans, Willem M. van der Wal, and Frits A. Wijburg. "Genistein in Sanfilippo disease: A randomized controlled crossover trial." Annals of Neurology 71, no. 1 (January 2012): 110–20. http://dx.doi.org/10.1002/ana.22643.

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Blackston, J., Andrew Chapple, James McGree, Suzanne McDonald, and Jane Nikles. "Comparison of Aggregated N-of-1 Trials with Parallel and Crossover Randomized Controlled Trials Using Simulation Studies." Healthcare 7, no. 4 (November 6, 2019): 137. http://dx.doi.org/10.3390/healthcare7040137.

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Background: N-of-1 trials offer an innovative approach to delivering personalized clinical care together with population-level research. While increasingly used, these methods have raised some statistical concerns in the healthcare community. Methods: We discuss concerns of selection bias, carryover effects from treatment, and trial data analysis conceptually, then rigorously evaluate concerns of effect sizes, power and sample size through simulation study. Four variance structures for patient heterogeneity and model error are considered in a series of 5000 simulated trials with 3 cycles, which compare aggregated N-of-1 trials to parallel randomized controlled trials (RCTs) and crossover trials. Results: Aggregated N-of-1 trials outperformed both traditional parallel RCT and crossover designs when these trial designs were simulated in terms of power and required sample size to obtain a given power. N-of-1 designs resulted in a higher type-I error probability than parallel RCT and cross over designs when moderate-to-strong carryover effects were not considered or in the presence of modeled selection bias. However, N-of-1 designs allowed better estimation of patient-level random effects. These results reinforce the need to account for these factors when planning N-of-1 trials. Conclusion: N-of-1 trial designs offer a rigorous method for advancing personalized medicine and healthcare with the potential to minimize costs and resources. Interventions can be tested with adequate power with far fewer patients than traditional RCT and crossover designs. Operating characteristics compare favorably to both traditional RCT and crossover designs.

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Equi, A., IM Balfour-Lynn, A. Bush, and M. Rosenthal. "Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial." Lancet 360, no. 9338 (September 2002): 978–84. http://dx.doi.org/10.1016/s0140-6736(02)11081-6.

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Dellemijn, Paul LI, and Jan AL Vanneste. "Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain." Lancet 349, no. 9054 (March 1997): 753–58. http://dx.doi.org/10.1016/s0140-6736(96)09024-1.

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Collister, David, Kayla Pohl, Gwen Herrington, Shun Fu Lee, Christian Rabbat, Karthik Tennankore, Deborah Zimmermann, et al. "The DIalysis Symptom COntrol-Restless Legs Syndrome (DISCO-RLS) Trial: A Protocol for a Randomized, Crossover, Placebo-Controlled Blinded Trial." Canadian Journal of Kidney Health and Disease 7 (January 2020): 205435812096895. http://dx.doi.org/10.1177/2054358120968959.

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Background: Restless legs syndrome (RLS) affects approximately 30% of patients with end-stage kidney disease and is associated with impaired sleep and health-related quality of life. Medications used to treat RLS in patients receiving dialysis may have an increased risk of adverse events with dose titration, and residual RLS symptoms are common despite the use of effective treatments. Randomized controlled trials of monotherapy and combination pharmacologic therapy for RLS in hemodialysis are needed. Objective: To perform a randomized, crossover, placebo-controlled blinded trial of pharmacologic therapy for RLS in hemodialysis. Design/setting: The DIalysis Symptom COntrol-Restless Legs Syndrome (DISCO-RLS) trial is a randomized, crossover, placebo-controlled blinded trial of fixed low-dose pharmacologic therapy in patients receiving hemodialysis in 10 centers across Canada. It uses patient partners in its design, conduct, and reporting. Participants: Adults receiving thrice-weekly hemodialysis for at least 3 months with RLS of at least mild symptoms defined International Restless Legs Syndrome Study Group Rating Scale (IRLS) of 10 or more will enter a double placebo run-in period to exclude nonadherent participants and those unable to tolerate double placebo. Seventy-two participants who completed the run-in period will be randomized to 1 of 8 treatment sequences based on modeling with 4 treatment periods. Methods: Each treatment period lasts 4 weeks and consists of ropinirole 0.5 mg daily and gabapentin 100 mg daily, both together or neither with a double dummy placebo control for each treatment. The primary outcome is the difference in change scores of the IRLS between study treatments. Secondary outcomes are the differences in change scores of the Restless Legs Syndrome-6 Scale, patient global impression, 5-level EQ-5D version, and safety outcomes. Results: This randomized, crossover, placebo-controlled blinded trial will evaluate the efficacy and safety of fixed low-dose combination of ropinirole and gabapentin in patients receiving hemodialysis with RLS. Limitations: Patients with chronic kidney disease not on dialysis, kidney transplant recipients and those receiving peritoneal dialysis or home hemodialysis are not included. The intervention’s long term safety and efficacy including the risk of augmentation is not captured. Conclusion: This randomized crossover placebo controlled blinded trial will evaluate the efficacy and safety of fixed low-dose combination ropinirole and gabapentin in patients receiving hemodialysis with RLS. Trial Registration: ClinicalTrials.gov (NCT03806530)

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Rowsell, Luke, Keith K. H. Wong, Brendon J. Yee, Danny J. Eckert, Andrew A. Somogyi, James Duffin, Ronald R. Grunstein, and David Wang. "The effect of acute morphine on obstructive sleep apnoea: a randomised double-blind placebo-controlled crossover trial." Thorax 74, no. 2 (August 30, 2018): 177–84. http://dx.doi.org/10.1136/thoraxjnl-2018-211675.

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ObjectiveAnaesthesiology guidelines suggest that opioids worsen obstructive sleep apnoea (OSA) despite no randomised controlled trial evidence. We therefore conducted a randomised controlled trial to evaluate the effects of a common clinical dose of morphine on OSA, and to identify clinical phenotype and genotype vulnerability to opioid-respiratory depression.MethodsUnder a double-blind, randomised, crossover design, 60 male patients with OSA attended two visits to the hospital sleep laboratory, at least 1 week apart. Either 40 mg controlled-release oral morphine or placebo was administered. Awake ventilatory chemoreflex tests were performed post dose and prior to overnight polysomnography monitoring. Blood was sampled before sleep and the next morning for toxicology and genotype analyses. Sleep time with oxygen saturation (SpO2) <90% (T90) was the primary outcome.ResultsDespite a large inter-individual variability, 40 mg morphine did not worsen T90 and apnoea–hypopnoea index, and only decreased the SpO2 nadir by 1.3%. In patients with severe OSA, a lower baseline CO2ventilatory response threshold correlated with the worsening of T90, apnoea–hypopnoea index and oxygen desaturation index with morphine use. Patients with OSA and the A118G OPRM1 polymorphism of A/A and A/G had a significantly different morphine effect on awake ventilatory chemosensitivity and T90 during sleep.Conclusions40 mg oral controlled-release morphine did not worsen OSA in men, challenging traditional thinking that OSA will be worsened by opioids. Individual opioid response in patients with OSA may relate to baseline CO2 response threshold and OPRM1 genotype. Our study findings may pave the way for a precision medicine approach to avoid opioid-related risks.Trial registration numberThe Australian and New Zealand Clinical Trial Registry, ACTRN12613000858796.

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Більше джерел

Дисертації з теми "Randomised controlled crossover trial"

Brymer, Christopher David. "A randomized, double-blind, placebo-controlled crossover trial of nimodipine for geriatric urge incontinence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29205.pdf.

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Davies, James. "A randomised controlled crossover trial to assess the effectiveness of, preference for and length of structured reply letters when communicating with referring practitioners." Thesis, University of Liverpool, 2011. http://livrepository.liverpool.ac.uk/3953/.

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Title A randomised controlled crossover trial to assess the effectiveness of, preference for and length of structured reply letters when communicating with referring practitioners Statement “I have made this letter longer than usual as I lack the time to make it short” (Blasie Pascal 1623-1662) Objectives To identify whether : 1. Structured reply letters from consultants were more effective at communicating with and/ or preferred by practitioners when compared to consultants’ standard reply letters. 2. There were differences in the length of the two formats. Null Hypothesis No significant difference exists between practitioner’s awareness of key patient information when receiving either the structured consultant reply letter or the standard consultant reply letter. No significant difference exists between the word counts of the two letter formats. Design Randomised controlled crossover trial. Setting Liverpool University Dental Hospital (LUDH). Participants and methods Participants were recruited from practitioners referring orthodontic patients to LUDH. Seventy five practitioners were stratified by consultant and randomised in blocks to receive either the structured or standard letter first, followed by the alternative format six weeks later. For both groups, the word count was recorded by the secretaries. ‘Knowledge and satisfaction’ questionnaires were dispatched with the letters, completed by practitioners and returned to the department. Outcome measures The primary outcome measure was the practitioners’ awareness of the key information contained within the letter. The secondary outcome measure was the secretarial typing times for the letters. Results The response rate was 87%. There was a statistically significant improvement in practitioners’ awareness of their patient’s status (odds ratio 8.84 95% CI 1.08, 72.52) and the action required (odds ratio 4.13 95% CI 1.10, 15.45) after receiving the structured letter. Practitioners showed a strong preference (p<0.001) for the structured consultant reply letter which were statistically significantly shorter than the standard format with a mean difference of 108 + 10 fewer words (mean difference: 108: 95% CI -118.14, -97.86). Conclusions This trial demonstrated that there was a statistical significant improvement in practitioners’ perceptual and actual awareness of their patient’s status and any action required, having received the structured letter. The structured reply letters had significantly fewer words than the standard letter. Practitioners strongly preferred the structured reply letter format.

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Costa, Fabio Wildson Gurgel. "Comparative preemptive analgesia evaluation of ibuprofen and etoricoxib in third molars surgery: a randomized, double-blind, placebo-controlled, crossover clinical trial." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9394.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico
Third molar surgery is a frequent procedure in dentistry related to variable degrees of postoperative pain. In this context, non-steroidal anti-inflammatory drugs have been commonly used in studies that evaluated the efficacy of preemptive analgesia as a strategy for pain control. Thus, the aim of the present study was to evaluate the preemptive analgesic efficacy and anti-inflammatory effect of ibuprofen and etoricoxib in mandibular third molar surgery, compared with a placebo. A randomized, double-blind, placebo-controlled crossover trial was conducted with patients undergoing a surgical removal of mandibular third molars with similar pattern of bone inclusion and surgical difficult between right and left sides, requiring bone removal under local anesthesia. Eighteen eligible patients were allocated into three groups to receive 1 hour preoperatively a single dose of ibuprofen 400 mg, etoricoxib 120 mg, or placebo. Pain intensity, use of analgesic rescue medication, swelling and maximum mouth opening were evaluated. The overall median (minimum - maximum) of pain scores was different between groups (p < 0.0001): ibuprofen, 0.0 (0.0 â 5.5); etoricoxib, 0.0 (0.0 â 3.5); placebo, 1.0 (0.0 â 7.0). Etoricoxib reduced pain scores significantly in comparison with ibuprofen (p < 0.05). The pain score peak occurred 6 hours after surgery between 3 compared groups (p < 0.0001). Rescue medication was used in 83.33%, 75%, and 100% of surgical procedures receiving ibuprofen, etoricoxib, and placebo, respectively (p = 0.1967). The mean of consumed rescue medication was different between ibuprofen (1.7Â2.0), etoricoxib (0.8Â06), and placebo (1.0Â2.7) groups over the study period (p = 0.0052), and was significantly lower in etoricoxib group by comparison with the placebo group (p < 0.05). Among study periods, there was no statistically significant difference between groups in relation to median values of facial swelling (p > 0.05) and mean values of maximum mouth opening (p > 0.05). In conclusion, ibuprofen and etoricoxib significantly reduced the intensity of postoperative pain and the need for use of rescue medication compared to placebo group. Etoricoxib showed a better preemptive analgesic activity than ibuprofen. Both drugs did not exert significant anti-inflammatory effect able to reduce swelling and trismus in comparison with placebo group.
A cirurgia de terceiros molares Ã um procedimento frequente em Odontologia relacionado a variados graus de dor pÃs-operatÃria. Nesse contexto, drogas anti-inflamatÃrias nÃo-estereoidais tÃm sido comumente utilizadas em estudos que avaliaram a eficÃcia da analgesia preemptiva como uma estratÃgia para controle da dor. Portanto, o objetivo do presente estudo foi avaliar a eficÃcia da analgesia preemptiva e aÃÃo anti-inflamatÃria do ibuprofeno e etoricoxibe em cirurgia de terceiros molares mandibulares comparado a um placebo. Foi realizado um ensaio clÃnico randomizado, duplo-cego, placebo-controlado cruzado com pacientes submetidos a cirurgia para remoÃÃo de terceiros molares mandibulares, com padrÃes similares de inclusÃo Ãssea e dificuldade cirÃrgica entre os lados direito e esquerdo, e que requeriam remoÃÃo Ãssea sob anestesia local. Dezoito pacientes elegÃveis foram randomicamente alocados em trÃs grupos para receber 1 hora preoperatoriamente dose Ãnica de ibuprofeno 400mg, etoricoxibe 120mg, ou placebo. Intensidade de dor, uso de medicaÃÃo analgÃsica de resgate, edema e mÃxima abertura bucal foram avaliados. A mediana (mÃnimo - mÃximo) global dos escores de dor diferiu entre os grupos (p < 0,0001): ibuprofeno, 0,0 (0,0 â 5,5); etoricoxibe, 0,0 (0,0 â 3,5); placebo, 1,0 (0,0 â 7,0). Etoricoxibe reduziu os escores de dor significantemente em comparaÃÃo ao ibuprofeno (p < 0,05). O pico de dor ocorreu 6 horas apÃs a cirurgia entre os 3 grupos comparados (p < 0,0001). MedicaÃÃo de resgate foi utilizada em 83,33%, 75% e 100% dos procedimentos cirÃrgicos que receberam ibuprofeno, etoricoxibe e placebo, respectivamente (p = 0,1967). A mÃdia de medicaÃÃo de resgate consumida diferiu entre os grupos ibuprofeno (1,7Â2,0) e etoricoxibe (0,8Â0,6) e placebo (1,0Â2,7) durante todo o perÃodo de estudo (p = 0,0052), e foi significantemente menor no grupo do etoricoxibe em comparaÃÃo com o grupo placebo (p < 0,05). Entre os perÃodos de avaliaÃÃo do estudo, nÃo existiu diferenÃa estatisticamente significante dos grupos entre si em relaÃÃo Ã mediana dos valores de edema facial (p > 0,05) e Ã mÃdia dos valores de mÃxima abertura bucal (p > 0,05). Em conclusÃo, ibuprofeno e etoricoxibe reduziram significantemente a intensidade de dor pÃs-operatÃria e a necessidade do uso de medicaÃÃo de resgate comparado ao grupo placebo. Etoricoxibe mostrou melhor atividade analgÃsica preemptiva do que o ibuprofeno. Ambas as drogas nÃo exerceram efeito anti-inflamatÃrio significante capaz de reduzir edema e trismo em comparaÃÃo ao grupo placebo.

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Reschke-Hernández, Alaine Elizabeth. "A clinical practice model of music therapy to address psychosocial functioning for persons with dementia: model development and randomized clinical crossover trial." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6842.

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Background: By 2050, it is estimated that 14 million older Americans will live with Alzheimer’s disease (AD), a progressive form of dementia with unknown cause or cure. Persons with AD and related dementias (ADRD) become increasingly dependent on others as they experience cognitive decline, which concomitantly undermines individuals’ functional skills, social initiative, and quality of life. The Alzheimer’s Association advocates for interventions that address cognition, mood, behavior, social engagement, and by extension, quality of life – goals music therapists often address. Although a small but growing body of literature suggests that clinical music therapy may be effective, the evidentiary support for the use and appropriate application of music as a form of treatment with this population is currently limited. Objectives: This thesis consisted of the development of a Clinical Practice Model of music therapy for persons with ADRD. It also examined the effectiveness of a specific, protocol-based music therapy intervention, grounded in this model, relative to a verbal discussion activity. Methods: The Clinical Practice Model is theoretically grounded in the biopsychosocial model of healthcare (Engel, 1980) and Kitwood’s (1997) personhood framework, and I developed it through extensive literature review and expert input. It includes an organizational schema for applying intervention strategies, per six themes: cognition, attention, familiarity, audibility, structure, and autonomy. The initial model predicts that an intervention built upon this schema will influence social-affective responses, quality of life, and in turn, psychosocial symptoms of ADRD. I tested a singing-based music therapy intervention, grounded in this model, through a randomized clinical crossover trial. I compared participants’ responses to music therapy to a non-music verbal discussion activity, and both conditions followed a protocol. Dependent variables included: (1) affective responses (self-reported feelings, observed emotions, and observed mood), (2) social engagement, and (3) observed quality of life. Thirty-two individuals with ADRD (n = 6 men, n = 26 women) ages 65-97 years old (μ̂ = 84.13) participated in this study. I randomly assigned treatment order; each treatment occurred in small-group format, three times per week in the afternoon (25 minutes each session), for two consecutive weeks. A two-week “wash-out” period occurred between conditions. Credentialed music therapists led both study conditions. This study followed recommendations from the National Institutes of Health Behavior Change Consortium (Bellg et al., 2004) to enhance quality assurance in protocol administration and data collection. Results and Significance: I used a linear mixed model approach to analysis. Music therapy exacted a significant, positive effect on self-reported feelings, observed emotions, and constructive engagement, particularly for individuals with moderate dementia. Results also suggested that men’s feelings improved in response to music therapy only, whereas women responded positively to both conditions. Weekly observations failed to indicate a significant change in mood or quality of life across the eight-week study. Based on these findings, I revised the Clinical Practice Model to include wellbeing (an outcome more concordant with psychosocial change in response to music intervention) rather than global quality of life (affected by numerous aspects of the care milieu). In addition to the Clinical Practice Model to the music therapy profession, contributions of this thesis include a rigorous clinical study and practical implications for music therapy practice, including the importance of considering patient characteristics and careful selection and implementation of music in a music therapy intervention.

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Page, Georgina L. J. "Oral thiamine (Vitamin B1) supplementation in subjects with type 2 diabetes mellitus : a randomised, double-blind, placebo-controlled crossover trial assessing biophysical markers of endothelial function, oxidant stress, insulin sensitivity and vascular inflammation." Thesis, University of Portsmouth, 2013. https://researchportal.port.ac.uk/portal/en/theses/oral-thiamine-vitamin-b1-supplementation-in-subjects-with-type-2-diabetes-mellitus(aac28b07-c232-4bc6-baed-4cbcb0531efa).html.

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Background and Aims Type 2 diabetes is increasing in prevalence and is associated with a threefold increased risk of cardiovascular mortality despite management of the traditional risk factors. Novel risk factors have been hypothesised that contribute to the pathogenesis of both type 2 diabetes and atherosclerosis and include oxidative stress, inflammation and endothelial dysfunction. Thiamine has been shown to be an important cofactor in the attenuation of these novel risk factors and people with type 2 diabetes have been shown to be thiamine deficient. This study tested the hypothesis that thiamine supplementation may improve endothelial function, oxidative stress, vascular inflammation and insulin resistance in subjects with type 2 diabetes who have a high cardiovascular risk profile. Methods Subjects with type 2 diabetes underwent a randomised, double blind, placebo-‐controlled crossover pilot study receiving 300mg daily of oral thiamine hydrochloride or placebo for eight weeks with a two week washout period. Measurements were taken for endothelial function (change in the reflective index post salbutamol using digital photoplethysmography, plasma cyclic GMP, plasma sVCAM-‐1, urinary albumin: creatinine ratio), insulin resistance (HOMA-‐IR), oxidative stress (glutathione ratio, CuPRAC-BCS) and inflammation (hsCRP) at the beginning and end of treatment with both thiamine and placebo. Results 34 patients (20 male) completed the study. Mean age 61 ± 9.4 years, HbA1c 7.46 ± 0.88%, blood pressure 137/77 ± 18/9 mmHg, total cholesterol 4.01 ± 1.11 mmol/l, HDL cholesterol 1.00 ± 0.30 mmol/l, triglycerides 1.87 ± 1.39 3 mmol/l. The majority of the patients were on two or more glucose lowering therapies with 88% on metformin. Most of the patients were on other cardiovascular disease modifying medications (statins or antihypertensive agents). Treatment with thiamine demonstrated a significant increase in thiamine diphosphate levels (310 ± 82 nmol/l post thiamine vs. 178 ± 32 nmol/l post placebo, p=<0.001) but no significant difference in markers of endothelial function, insulin resistance, oxidative stress or inflammation or other metabolic markers. Conclusion In this cohort of patients treatment with 300mg per day of oral thiamine for eight weeks in well-‐controlled type 2 diabetes at high cardiovascular risk, demonstrated no significant improvement in endothelial function, insulin resistance, oxidative stress or inflammation.

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Dragan, Irina F. "The Impact of the Evidence-Based Clinical Decision Support Resource "UpToDate" on the Speed and Accuracy of Determining Drug-Drug-Interactions in a Dental Setting| A Randomized Crossover Controlled Pilot Trial." Thesis, Tufts University School of Dental Medicine, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10839656.

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Aim & Hypothesis: The aim of the study was to compare the time dental students need to answer questions about drug-drug interactions (DDI) when using the Evidence-Based Clinical Decision Support Resource (EBCDSR) UpToDate^® to retrieve patient-critical information versus general internet access, during a preclinical session. We hypothesized that the dental students utilizing the UpToDate^® would take less time to identify the correct DDIs and obtain higher examination scores, compared with the group with only internet access.

Materials & Methods: The proposed study design was a randomized blinded crossover controlled pilot and each subject examined four computer-based virtual cases, during two study visits. In the first visit, one group assessed two cases presented in axiUm (Tufts University School of Dental Medicine’s electronic health record system), using UpToDate^® access and the other group, using their own electronic resources assessed other two cases with no UpToDate^® access, and determined the DDI. At the second visit, after the ten days wash-out period, the cross-over took place. Each case was followed by three questions regarding the drug-drug interactions, focusing on the use of antibiotics, analgesics and local anesthetics. The mean time duration of the sessions conducted by each subject was captured and calculated. Chi-square tests were used for the statistical analysis of the examination scores. All statistical analyses were performed using SAS Version 9.2 (SAS Institute, Cary, NC).

Results: A total of 50 dental students presented for the first study visit and 44 dental students for the second study visit. The third year dental students utilizing the UpToDate^® took a similar amount of time to identify the correct DDIs compared with the third year dental students with no UpToDate^® access and only internet access (p-value = 0.429). Both groups obtained similar examination scores for all the questions related to antibiotics (p-value = 0.797), analgesics (p-value = 0.850) and local anesthetics (p-value = 0.850).

Conclusions: The current study has shown that UpToDate^® can provide answers to clinical questions at the point of care in a timely manner, with a high level of student satisfaction. Future studies might involve a more seamless entry into EBCDSR’s using “Infobutton” in the Electronic Health Record (EHR).

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Newbury, Jonathan. "75+ health assessments : a randomised controlled trial." Title page, contents and abstract only, 2001. http://thesis.library.adelaide.edu.au/adt-SUA/public/adt-SUA20011123.113220.

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Includes bibliographical references. Electronic publication; full text available in PDF format; abstract in HTML format. The aims of this study were to compare preventative care for the elderly, known as 75+ Health Assessment (75+ HA), with usual care in a randomised controlled trial in the elderly living independently in their own home. Further, the study aims to evaluate whether there are measurable differences in defined primary and secondary outcome measures between the control and intervention groups. The results of the trial are discussed and recommendations made. Electronic reproduction.[Australia] :Australian Digital Theses Program,2001. 283, [15] leaves : ill. ; 30 cm.

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Finnegan, Olwyn Ava. "Facilitating cardiac rehabilitation behaviours : a randomised controlled trial." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410935.

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Barkun, Jeffrey S. "A randomised controlled trial comparing laparoscopic to mini cholecystectomy /." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68154.

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To better define the differences between laparoscopic (LC) and mini cholecystectomy (MC) in treating cholelithiasis, we conducted a randomized controlled trial with 70 patients (LC:38, MC:32).
Both groups were comparable at baseline. The median length of post-operative hospital stay and time to full diet were significantly shorter in LC than MC (p $<$ 0.005 for both). Mean duration of convalescence was 11.9 ($ pm$9.1) days for LC and 20.2 ($ pm$16.5) days for MC (p = 0.04). Kaplan-Meier survival analysis confirmed these results. Using Cox's proportional hazards model, duration of convalescence was only found to be associated with the type of cholecystectomy performed. Three quality of life scores showed that LC patients improved more quickly than MC patients after cholecystectomy.
Surgeons underestimated convalescence on average by 25% (p $<$ 0.01) when compared to nurses' measurements.
In conclusion, even though recovery after MC was shorter than generally anticipated, time to recovery from LC was still shorter and more predictable than MC.

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Schroer, Sylvia. "Developing a randomised controlled trial of acupuncture for depression." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538622.

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Книги з теми "Randomised controlled crossover trial"

Brymer, Christopher David. A randomized, double-blind, placebo-controlled crossover trial of nimodipine for geriatric urge incontinence. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1999.

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Drury, Valerie Mary. Cognitive therapy and recovery from acute psychosis: A randomised controlled trial. Birmingham: University of Birmingham, 1999.

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Sawyer, Lynn. Low vs high glycaemic index bedtime snacks for patients with type 1 diabetes, which should we be encouraging?: A randomised controlled cross-over trial. Roehampton: University of Surrey Roehampton, 2004.

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Wilson, Patricia Ann. Can a soother do more than soothe?: A randomised controlled trial to determine the effects of non-nutritive sucking on feeding and growth in preterm infants. [S.l: The Author], 1998.

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Roukema, Henry. A randomised controlled trial of infant flow continuous positive airway pressure versus nasopharyngeal continuous positive airway pressure in the extubation of infants [less then a equal]1250 grams. Ottawa: National Library of Canada, 2003.

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Hall, M. A prospective randomised controlled trial to compare Duoderm, a thin hydocolloid dressing, with Jelonet, a paraffin gauze product in the management of fingertip amputation wounds that do not require surgical intervention. Oxford: Oxford Brookes University, 2002.

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N, Caine, National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. A randomised controlled crossover trial of nurse practitioner versus doctor-led outpatient care in a bronchiectasis clinic. Southampton: NCCHTA, 2002.

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Peacock, Janet L., and Sally M. Kerry. Presenting a randomised controlled trial. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780198599661.003.0012.

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Harrison, Mark. Types of trials. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0059.

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This chapter describes types of trials as applied to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details and advantages and disadvantages of case reports, case series, cohort studies, case–control studies, randomized controlled trials, crossover trials, systematic reviews, and meta-analysis. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.

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Burke, Rebecca, and Akhila Reddy. Duloxetine for Chemotherapy-Induced Peripheral Neuropathy (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0015.

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This chapter discusses the Smith et al. randomized, double-blind, placebo-controlled crossover trial determining the effectiveness of duloxetine compared to placebo in reducing painful chemotherapy-induced peripheral neuropathy. Patients were divided into the duloxetine-first or placebo-first group, then subsequently crossed over to the alternate group. The study particularly examined changes in pain severity, quality of life, interference with daily function, and adverse events. The study demonstrated that patients receiving duloxetine first reported a statistically significant decrease in pain, improvement in quality of life, and decreased pain interference with daily functioning. This chapter describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case.

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Частини книг з теми "Randomised controlled crossover trial"

Amirah Fatin, I., L. A. Khatijah, M. S. A. Zilany, A. Z. Zuheir, S. H. Ong, and M. P. Tan. "The Effect of Hearing Augmentation on Cognitive Assessment Scores: A Pilot Crossover Randomized Controlled Trial." In IFMBE Proceedings, 24–29. Singapore: Springer Singapore, 2015. http://dx.doi.org/10.1007/978-981-10-0266-3_6.

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Bolognese, James A., and Yevgen Tymofyeyev. "Case Study: Design Considerations for a Phase Ib Randomized, Placebo-Controlled, 4-Period Crossover Adaptive Dose-Finding Clinical Trial." In Practical Considerations for Adaptive Trial Design and Implementation, 341–55. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1100-4_18.

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Bulpitt, Christopher J. "Different Trial Designs." In Randomised Controlled Clinical Trials, 57–83. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_5.

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Bulpitt, Christopher J. "Information to be Collected During a Trial." In Randomised Controlled Clinical Trials, 183–98. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_10.

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Bulpitt, Christopher J. "The Objectives of a Randomised Controlled Trial." In Randomised Controlled Clinical Trials, 45–55. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_4.

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Bulpitt, Christopher J. "The Conduct of the Trial — Good Clinical Practice." In Randomised Controlled Clinical Trials, 199–231. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_11.

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Bulpitt, Christopher J. "How Many Subjects are Required For a Trial?" In Randomised Controlled Clinical Trials, 85–112. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_6.

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Scott, Jan. "A Randomised Controlled Trial of Cognitive Therapy in Bipolar Disorders." In Cognitive Psychotherapy Toward a New Millennium, 285–88. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0567-9_47.

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Boylan, P., D. MacDonald, A. Grant, M. Pereira, and I. Chalmers. "The Dublin Randomised Controlled Trial of Intrapartum Electronic Fetal Heart Rate Monitoring." In Fetal Heart Rate Monitoring, 34–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70358-4_4.

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Evans, Debra. "Let's talk about the characteristics of a quantitative design – the randomised controlled trial." In Making Sense of Evidence-based Practice for Nursing, 50–63. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003156017-8.

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Тези доповідей конференцій з теми "Randomised controlled crossover trial"

Wong, Conroy, Catherina Chang, Chris Lewis, Alain Vandal, Lata Jayaram, Stuart Jones, David Milne, et al. "Tiotropium treatment for bronchiectasis (ROBUST): a randomized, placebo-controlled, crossover trial." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa1809.

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Howard, Luke, Jian-Guo He, John Wharton, Geoffrey Watson, Henning Gall, Hossein Ghofrani, Li Huang, et al. "Late Breaking Abstract - Supplementation of iron in pulmonary hypertension (SIPHON): results from a randomised controlled crossover trial." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa3947.

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Stanford, GE, F. Cathcart, Z. Beverley, C. Short, M. Jones, D. Bilton, JC Davies, and NJ Simmonds. "P243 Outcome measures for airway clearance in adults with cystic fibrosis (CF): a randomised controlled crossover trial." In British Thoracic Society Winter Meeting 2019, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 4 to 6 December 2019, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2019. http://dx.doi.org/10.1136/thorax-2019-btsabstracts2019.386.

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Visca, Dina, Sharon Fleming, Ashi Firouzi, Morag Farquhar, Nicholas Hopkinson, Charlotte Hogben, Winston Banya, et al. "Randomised controlled, crossover trial to evaluate the effects of ambulatory oxygen on health status in patients with fibrotic lung disease." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa797.

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Combret, Yann, Clément Médrinal, Guillaume Prieur, Aurora Robledo Quesada, Pascal Le Roux, and Grégory Reychler. "Comparative effect of backpack carrying on cystic fibrosis and healthy children: a randomized crossover controlled trial." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa1341.

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Sujimongkol, Chinakorn, Suntharee Wichakhreuang, Pattaraporn Wongput, and Somsri Daochai. "Randomized Controlled Crossover Trial to Evaluate the Efficacy of Rinsing Techniques for Removal of Disinfectant in Hemodialyzer." In 2019 12th Biomedical Engineering International Conference (BMEiCON). IEEE, 2019. http://dx.doi.org/10.1109/bmeicon47515.2019.8990229.

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Hirai, Daniel, Joel Zelt, Joshua Jones, Robert Bentley, Wendy Earle, Patti Staples, Michael Tschakovsky, John McCans, Denis O'Donnell, and J. Alberto Neder. "Dietary nitrate supplementation and exercise tolerance in chronic heart failure: A double-blind, randomized, placebo-controlled, crossover trial." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa2278.

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Giassi, Karina, Renato Gorga Bandeira de Mello, Bruna Cambrussi de Lima, Gabriela Stahl, Raquel Almeida de Oliveira, and Marina Siqueira Flores. "RANDOMIZED CONTROLLED TRIAL COMPARING MORNING VERSUS NIGHT ADMINISTRATION OF LEVOTHYROXINE IN OLDER PERSONS." In XXII Congresso Brasileiro de Geriatria e Gerontologia. Zeppelini Publishers, 2021. http://dx.doi.org/10.5327/z2447-21232021res04.

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OBJECTIVE: To evaluate the effectiveness of levothyroxine administration strategies in the treatment of hypothyroidism in older persons in a tertiary outpatient clinic. METHODS: A randomized controlled trial of older persons with a diagnosis of primary hypothyroidism who had been receiving levothyroxine for at least 6 months with a stable dose in the last 3 months. Patients were randomly assigned to one of two administration strategies: morning (1 hour before breakfast) or night (1 hour after the last meal). In a period ≥ 12 weeks, patients were instructed to cross over between strategies. Laboratory tests for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were performed at visit 0 (baseline), visit 1 (period ≥ 12 weeks), and visit 2 (completion — period ≥ 24 weeks); a standardized questionnaire was also applied. Preliminary analyses of the period before crossover are presented. RESULTS: The preliminary sample consisted of 98 patients, with a mean age of 71.26 (SD 7.12) years; 83.67% were women. Fifty-three patients started with the morning strategy and 45 with the night strategy, and one patient did not return for reassessment. Median TSH levels ranged from 2.74 (IQR 1.06–4.19) at baseline to 2.77 (IQR 0.75–4.41) after a 12-week follow-up in the morning group, and from 2.36 (IQR 1.48–4.85) to 2.28 (IQR 1.69–3.56) in the night group. Mean FT4 levels ranged from 1.44 (SD 0.39) to 1.42 (SD 0.36) in the morning group, and from 1.35 (SD 0.27) to 1.37 (SD 0.32) in the night group. CONCLUSIONS: The administration of levothyroxine at night was as effective as morning administration at controlling primary hypothyroidism in older persons. Therefore, this can be considered an alternative dosage strategy for the treatment of this condition.

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Ljungberg, Henrik, Anna Carleborg, and Björn Nordlund. "Clinical effect on asthma control using a novel digital self-management solution: a physician blinded randomized controlled crossover trial." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.oa5343.

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Marques Da Silva, Cibele C. B., Douglas Silva Queiroz, Rodrigo A. Athanazio, Simone Dal Corso, Samia Rached, Adriana C. Lunardi, Renato Vitorasso, Henrique T. Moriya, Alfredo Fonseca, and Celso R. F. Carvalho. "The effect of bronchodilators in the exercise capacity and thoracoabdominal mechanics of subjects with bronchiectasis: a randomized crossover, double-blinded, placebo-controlled trial." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.286.

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Звіти організацій з теми "Randomised controlled crossover trial"

Conte, Ianina. Randomised, double blind, placebo controlled, crossover trial of the adjuvant properties of Imipramine for the overactive bladder. National Institute for Health Research, May 2021. http://dx.doi.org/10.3310/nihropenres.1115147.1.

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Haylock, Stuart. Brief alcohol intervention to reduce risky drinking in pregnancy: a pilot randomised controlled trial. National Institute for Health Research, May 2021. http://dx.doi.org/10.3310/nihropenres.1115148.1.

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Chen, Gengbin, Tuo Lin, Manfeng Wu, Guiyuan Cai, Qian Ding, Jiayue Xu, Wanqi Li, Cheng Wu, Hongying Chen, and Yue Lan. Effects of repetitive transcranial magnetic stimulation on upper-limb and finger function in stroke patients: a systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0121.

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Review question / Objective: P:Adult patients (age ≥ 18 years) diagnosed with stroke based on relevant clinical examination; I:Intervention group with rTMS alone or in combination with other treatments with rTMS; C:Control group received sham treatment or no rTMS; O: Upper extremity function:the Fugl-Meyer Assessment Upper Extremity (FMA-UE); Hand function:box and block test(BBT), nine-hole peg test(NHPT), and Purdue pegboard test(PPT); S:Randomized controlled trials (rather than crossover designs). Condition being studied: In Europe, more than 1 million new cases of stroke are reported each year. The absolute number of stroke patients is expected to increase in the near future due to the progressive aging of the population. Approximately 50-80% of stroke survivors present with upper extremity dysfunction. Recovery of upper extremity function is associated with improvements in activities of daily living and mental health. However, few stroke survivors show full recovery of upper extremity function 6 months after stroke. In addition, rehabilitation has a limited impact on the recovery of hand motor function.

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Li, Yibing, Jinming Song, Xuhui Wang, Lin Han, and Bangqi Wu. Acupuncture versus pharmacological resuscitation in treatment of atrial fibrillation in a randomised controlled trial: systemic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0108.

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Walsh, Phoebe. A randomised controlled trial of total resurfacing versus hemi resurfacing in the treatment of primary osteoarthritis of the shoulder. National Institute for Health Research, February 2022. http://dx.doi.org/10.3310/nihropenres.1115180.1.

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Landon, Tess, and Harald Hochreiter. Randomised controlled trials and other experimental approaches in the Austrian Research Promotion Agency. Fteval - Austrian Platform for Research and Technology Policy Evaluation, April 2022. http://dx.doi.org/10.22163/fteval.2022.554.

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The objective of this paper/presentation is to highlight how experimental approaches, specifically Randomised Controlled Trials (RCTs), can be leveraged to evaluate and measure the impact of new programmes, support programme development and test new services in funding and innovation agencies. RCTs are seen in many facets of public policy, however RCTs as a method for innovation agencies to evaluate new initiatives is relatively new. We present three RCTs implemented in the Austrian Research Promotion Agency (FFG) that have received funding from the European Union’s Horizon 2020 research and innovation programme. The trials are implemented to evaluate the effectiveness of new measures intended to help strengthen R&I in start-ups and SMEs. Through these three examples, we aim to demonstrate the advantages in which RCTs can augment the evaluation of new services as well as challenges that come with implementing RCTs. For one RCT, we will present final results. Two RCTs are ongoing, and we will present the trial design. We also discuss the operational aspects of incorporating experimentation in an innovation agency.

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Abreu, Rodrigo, Catarina B. Oliveira, Júlio Costa, João Brito, and Vítor Hugo Teixeira. Effect of dietary supplements on athletic performance in elite soccer players: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0088.

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Review question / Objective: The aim of this systematic review is to evaluate the effect of dietary supplements on athletic performance in elite soccer players. Eligibility criteria: This review will be conducted based on the PRISMA guidelines and the PICOS approach. Articles were eligible if they were published or in-press in peer-reviewed journals (i.e., abstracts published in conference proceedings, books, theses, and dissertations will not be considered), published in English language with available abstract for screening. The PICOS approach will be established as follows: Population: highly trained or elite, adult (>18 years old) male or female soccer players; Intervention: use of one or more dietary supplements for performance; Comparison: same conditions with placebo or without dietary supplements; Outcome: athletic or soccer-related performance outcomes; Study design: intervention in parallel groups or with crossover, blind or double-blind, and randomized controlled trials (experimental studies).

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Conte, Ianina. A pilot randomised controlled single-blind trial of a collagen implant for the prevention of sternal wound infection in cardiac surgery. National Institute for Health Research, January 2022. http://dx.doi.org/10.3310/nihropenres.1115176.1.

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Çalışkan Sarı, Arzu, and Özden Yalçınkaya Alkar. Randomised Controlled Trial of Online Empathy Focused Intercultural Communication Program for Turkish Local Society to Increase Their Social Acceptance Towards Refugees. Peeref, July 2022. http://dx.doi.org/10.54985/peeref.2207p6946207.

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Sandeep, Bhushan, xin Huang, and Zongwei Xiao. Analgesic efficacy of erector spinae plane block in arthroscopic shoulder surgery: a systemic review and meta-analysis of randomised controlled trial. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0084.

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Review question / Objective: Erector spinae plane block (ESPB) has been employed in arthroscopic shoulder surgery (ASS) as an alternative novel interfacial plane block. However, its analgesic efficacy is still controversial. Whether ESPB could improve analgesic efficacy in ASS is what the current meta-analysis seeks to find out. Information sources: We searched different databases including the Cochrane Library, PubMed, Embase, and Web of Science from inception to November 29, 2022, using medical subject headings (MeSH) and free-text terms without language restrictions. The primary purpose of searching was for the selection of RCTs for meta-analysis but also to avoid unplanned duplication and compare reported review methods from other systematic reviews. The following search terms were used for the search of each database: “arthroscopic shoulder surgery”, “shoulder surgery”, “total shoulder arthroplasty”, “shoulder arthroscopy”, and “erector spinae plane block”, “erector spinae muscle”. We also searched for grey literature by supplementary hand searching.

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