Готові списки джерел за темами / Reception of trauma

Добірка наукової літератури з теми "Reception of trauma"

Автор: Grafiati

Опубліковано: 4 травня 2022

Оновлено: 5 травня 2022

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Статті в журналах з теми "Reception of trauma":

Fitzgerald, Mark C., Adam B. Bystrzycki, Nathan C. Farrow, Peter A. Cameron, Thomas Kossmann, Michael E. Sugrue, and Colin F. Mackenzie. "TRAUMA RECEPTION AND RESUSCITATION." ANZ Journal of Surgery 76, no. 8 (August 2006): 725–28. http://dx.doi.org/10.1111/j.1445-2197.2006.03841.x.

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Fitzgerald, M. "Trauma reception and resuscitation project." Injury 40 (February 2009): S15. http://dx.doi.org/10.1016/j.injury.2009.01.068.

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Fitzgerald, M., C. F. Mackenzie, S. Marasco, R. Hoyle, and T. Kossmann. "Pleural decompression and drainage during trauma reception and resuscitation." Injury 39, no. 1 (January 2008): 9–20. http://dx.doi.org/10.1016/j.injury.2007.07.021.

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Patel, Katie J., Kristy Williamson, Laura LaMaina, and Francesca Bullaro. "Trauma Takeaways: Reception and Utilization of a Postsimulation Newsletter." Journal of Trauma Nursing 28, no. 4 (July 2021): 265–78. http://dx.doi.org/10.1097/jtn.0000000000000595.

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Greenslade, G. L., and R. H. Taylor. "Advanced Trauma Life Support aboard RFA Argus." Journal of The Royal Naval Medical Service 78, no. 1 (March 1992): 23–26. http://dx.doi.org/10.1136/jrnms-78-23.

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SummaryThe Advanced Trauma Life Support (ATLS) system was adopted for casualty reception and resuscitation. ATLS permitted well-informed triage decisions to be made, coupled with appropriate initial, possibly life-saving, treatment. The training given on board has continued to benefit patients treated by ex-Argus staff in their peacetime roles.

Singh Tveit, Megha, Eshana Singh, Alexander Olaussen, Susan Liew, Mark C. Fitzgerald, and Biswadev Mitra. "What is the purpose of log roll examination in the unconscious adult trauma patient during trauma reception?" Emergency Medicine Journal 33, no. 9 (June 9, 2016): 632–35. http://dx.doi.org/10.1136/emermed-2015-205450.

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Sawicka-Mierzyńska, Katarzyna. "Trauma w procesie – o podlaskiej recepcji bieżeństwa." Białostockie Studia Literaturoznawcze, no. 19 (2021): 27–49. http://dx.doi.org/10.15290/bsl.2021.19.02.

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The article discusses the reception of bieżeństwo – the exodus of about three million inhabitants of the western borderlands of the Russian empire deep into Russia in 1915. It was part of the “scorched earth” tactics conducted by the tsarist authorities, which were supposed to hinder the German army’s march eastward. Using the category of “cultural trauma” formulated by J.C. Alexander, the author seeks to dicover why biezenstwo did not become a part of the collective memory of Poles and how it now functions in the collective memory of Podlasie residents. The research was based primarily on Aneta Prymaka-Oniszk’s reportage Bieżeństwo 1915. Zapomniani uchodźcy [Biezhenstvo 1915. Forgotten refugees] and the anthology Jestem, bo wrócili [I am because they came back].

Lee, Geraldine A., Angela Murray, Rosie Bushnell, and Louise E. Niggemeyer. "Challenges developing evidence-based algorithms for the trauma reception and resuscitation project." International Emergency Nursing 21, no. 2 (April 2013): 129–35. http://dx.doi.org/10.1016/j.ienj.2012.01.005.

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Flavin, Brian M., and Peter A. Driscoll. "Organizing and training the emergency department in the reception of major trauma." Emergency Medicine Australasia 12, no. 2 (June 2000): 112–15. http://dx.doi.org/10.1046/j.1442-2026.2000.00102.x.

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Pukhonska, Oksana. "Traumatic Memory in Ukrainian Literary Reception: Symptoms of Post-dependence." Przegląd Wschodnioeuropejski 10, no. 2 (December 30, 2019): 241–50. http://dx.doi.org/10.31648/pw.5477.

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The paper is devoted to analysis of the post-totalitarian memory in literary reception of Ukraine. After the decades of ignoring, this memory became the driving force of social processes and the construct of national identity. The author pays attention to the social trauma of soviet repressions and Second World War, which negatively influenced cultural consciousness of the society. Displaced and forgotten memory is understood as the main reason for lack of progress in the post-Soviet Ukraine. The traumatic experience of the past turned out to be both a lesson and an incentive for large-scale public and conscious transformations, about which modern authors write.

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Дисертації з теми "Reception of trauma":

Hori, Ryusuke. "PROSTAGLANDIN E RECEPTOR SUBTYPE EP4 AGONIST PROTECTS COCHLEAE AGAINST NOISE-INDUCED TRAUMA." Kyoto University, 2010. http://hdl.handle.net/2433/120543.

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Reys, Luiz Guilherme Cintra Vidal. "Importância do receptor toll-símile 4 ("toll-like receptor 4") na disfunção da barreira intestinal após trauma e choque hemorrágico experimental." reponame:Repositório Institucional da UnB, 2013. http://repositorio.unb.br/handle/10482/15298.

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Tese (doutorado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, 2013.
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Introdução: A ativação do receptor Toll-símile 4 ou ?Toll-Like Receptor-4 (TLR4)??após lesão estéril leva à disfunção de órgãos em locais distantes. Tem sido demostrado anteriormente que a ruptura da barreira intestinal e alteração em proteínas das junções apertadas segue-se ao choque trauma/choque hemorrágico (T/HS), no entanto, o papel de TLR4, este processo permanece obscuro. Foi postulado que o aumento da permeabilidade e a ruptura da barreira intestinal após T/HS é um processo TLR4 dependente, portanto, silenciar o gene TLR4 teria um efeito protetor sobre a disfunção intestinal induzida por T/HS. Método: Camundongos machos C57BL/6J (TLR4+/+ do tipo selvagem ou “wild-type” [WT]) e C57BL/10ScN (TLR4-/- transgênico ou “knockout” [K0]) foram distribuídos aleatoriamente e submetidos a T/HS (laparotomia mediana + choque hemorrágico com pressão arterial média mantida em 35mmHg por 60 minutos) ou submetidos a operação simulada. Após 4h, a permeabilidade ao isotiocianato de fluoresceína (FITC)-dextrano administrado intraluminalmente foi avaliada por quantificação da fluorescência do plasma. Amostras intestinais foram analisadas para a presença das proteínas das juncoes apertadas, ocludina e ZO-1, por imunohistoquímica. Resultados: As concentrações séricas de FITC-dextran 4kDa estavam diminuídas no grupo TLR4-/-[K0] em comparação com camundongos TLR4+/+[WT] quando submetidos ao modelo de T/HS (38,96 vs 164,26 ?g/ml, respectivamente, p<0,05). Não foram observadas diferenças na permeabilidade intestinal entre os camundongos TLR4-/-[K0] e os animais do grupo simulação TLR4+/+[WT]. Os camundongos K0 tiveram preservação das concentrações de ocludina e ZO-1 após a lesão T/HS em ensaios de imunohistoquímica, mas as concentrações estavam reduzidas em animais WT. Conclusão: Camundongos com TLR4-/-[K0] demonstraram menor permeabilidade intestinal ao FITC-dextrano do que camundongos WT após lesão por T/HS resultantes de alterações nas proteínas das junções apertadas, ocludina e ZO-1. Estes achados sugerem que a maior permeabilidade e a ruptura da barreira intestinal após lesão por T/HS é um processo TLR4-dependente. ________________________________________________________________________________ ABSTRACT
Objective: Toll-like receptor 4 (TLR4) activation after sterile injury leads to organ dysfunction at distant sites. Has been shown previously that intestinal barrier breakdown and alteration of tight junction proteins follows trauma/hemorrhagic shock (T/HS); however, the role of TLR4 in this process remains unclear. Was postulated that increased intestinal permeability and barrier breakdown after T/HS is a TLR4 dependent process; hence, knocking down the TLR4 gene would have a protective effect on T/HSinduced intestinal dysfunction. Method: Male C57BL/6J (TLR4 wild type [WT]) and C57BL/10ScN (TLR4 knockout [K0]) mice were assigned randomly to either T/HS (femoral catheterization + laparotomy + hemorrhagic shock) or sham injury. At 4h, permeability to intraluminally administered fluorescein isothiocyanate (FITC)-dextran was assessed by measuring the fluorescence of the serum. Intestinal samples were analyzed for the presence of the tight junction proteins, occludin and ZO-1, by immunohistochemistry. Results: Serum concentrations of FITC-dextran were decreased in K0 mice compared with WT mice after T/HS injury (38,96 ?g/ml and 164,26 ?g /ml, respectively; p<0,05). After injury, no difference in intestinal permeability was observed between the K0 mice and the WT shamtreated mice. The K0 mice had preservation of occluding and ZO-1 concentrations after T/HS injury in immunohistochemistry assays, but concentrations were decreased in WT animals. Conclusions: Mice with TLR4K0 have less intestinal permeability to FITC-dextran than WT mice after T/HS injury as a result of alterations in the tight junction proteins occludin and ZO-1. These findings suggest that the greater intestinal permeability and barrier breakdown after T/HS injury is a TLR4-dependent process.

Liang, Chengya. "Extracullular ATP Regulates IL-1Beta Release from Microglial Cells Via Purinergic Receptor After In Vitro Trauma." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4420.

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Traumatic brain injury (TBI) induces a state of microglialactivation, which includes upregulation of macrophage functions and release inflammatory mediators such as certain inflammatory cytokines. Current literature suggests that interleukin-1Beta is an important cytokine mediator, which is dramatically increased after brain injury. Previous studies indicate that ATP is released by traumatically injured astrocytes and serves as a cell-to-cell mediator through purinergic receptors after in vitro injury. However, the mechanism of interleukin-1Beta release after traumatic brain injury remains poorly defined and is difficult to study using in vivo models. Using an in vitro model for traumatic brain injury (cell strain or stretch), we investigated the role of the extracellular nucleotides (ATP) in regulation of interleukin-1Beta release in rat cortical brain cells. We now report that activated microglia constitute the major source of interleukin-1Beta release after in vitro trauma. ATP is a powerful stimulus for interleukin-1Beta release from microglial cultures. Glutamate inhibits interleukin-1Beta release. ATP-induced interleukin-1Beta release was blocked completely by the P2X7 receptor antagonist, oxidized ATP, and partially by the P2X7 receptor antagonist suramin, suggesting that ATP stimulates interleukin-1Beta release from microglia via purinergic receptor and the P2X7 receptor is responsible for the interleukin-1Beta release. Blockage of interleukin-1Beta release by the purinergic receptor antagonists oATP and suramin decreased cell damage in uninjured mixed organotypic brain cell culture exposed to activated microglia. Taken together, these results suggest that interleukin-1Beta mediated inflammatory events are regulated in activated microglia by extracellular nucleotides (ATP) via purinergic receptors in central nervous system after in vitro trauma.
M.S.
Department of Molecular Biology and Microbiology
Burnett College of Biomedical Sciences
Molecular Biology and Microbiology

Rumball, Freya. "Studying individual differences and emotion regulation effects on PTSD-like responding and recovery : a psychophysiological VR-trauma paradigm." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/14171.

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Despite a high proportion of the population experiencing traumatic events within their lifetime, the number of individuals who go on to develop posttraumatic stress disorder (PTSD) is comparatively small; herein highlighting the importance of individual differences in imparting risk and resilience towards the development and maintenance of PTSD. Existing literature illustrates that biological and ecological factors are important in predicting PTSD development, with pathological vulnerabilities excepting their effects at pre- peri- and post trauma stages. Whilst cognitive and emotion based models of PTSD account for the role of a minority of known pre-trauma risk factors, individual differences in peri- and post trauma processes are held as critical to the development of PTSD. The broad range of risk factors implicated in the empirical literature, and necessity of traumatic exposure to PTSD, implicates the utility of a diathesis-stress conceptualisation of PTSD development. The current thesis employed an analogue VR-trauma paradigm to investigate the respective importance of vulnerability factors at each stage, in the prediction of analogue PTSD symptoms (memory problems, startle responses, re-exposure fear habituation), whilst measuring affective and electrophysiological concomitance. Findings supported the importance of peri-traumatic responses in the prediction of PTSD, where present, showing increased predictive capacities over pre- and post-trauma factors. Biological and ecological factors also illustrated important predictive associations, with genetic SNPs implicated in reflex startle and cardiac responses towards intrusive memories. Moreover, peri-traumatic HR decelerations and accelerations mediated the association between pre-trauma factors and cued recall inaccuracy and intrusion severity respectively. Results support existing cognitive and emotional models in their emphasis on peri-traumatic processes but suggest the added utility of a diathesis stress conceptualisation of the development of PTSD, in highlighting the importance of pre-trauma biological and ecological risk and resilience factors.

Weber, Sascha [Verfasser]. "Die Rolle des necroptotischen Zelltodes und der Receptor Interacting Protein Kinase 1 (RIPK1) in der septischen akuten Lungenschädigung nach Trauma / Sascha Weber." Ulm : Universität Ulm. Medizinische Fakultät, 2016. http://d-nb.info/1081432217/34.

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Okada, Mikiko. "Blockade of the N-methyl-D-aspartate-type glutamate receptor in the animal : Target for neuroprotection in head trauma and brain ischemia." Kyoto University, 1998. http://hdl.handle.net/2433/182421.

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Lindsay, Heather Schofield. "Exposure to Dietary Selenium and Soy Isoflavones in Utero Provides Greater Protection Against Prostate Cancer Risk Factors in TRAMP Mice than Exposure Beginning at 6 Weeks." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3228.

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Prostate cancer is the second most commonly occurring cancer in men in the United States. Generally, an extended period of time is needed for a mutation to develop into a full scale tumor. Because of this long latency period, lifestyle and environmental factors, such as diet, may play an important role in the development and progression of the disease. Diet is one factor that has been implicated in the risk for developing prostate cancer. We previously showed that diets high in soy isoflavones and selenium (Se) decreased androgen receptor expression and expression of androgen regulated genes in healthy rat prostates. The purpose of this study was to determine whether treatment of soy isoflavones and/or supplemental Se provide chemopreventive effects in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model of prostate cancer, and whether the timing of the introduction of these nutrients determines protective effects. Male hemizygous C57/BL6 x FVB TRAMP mice were exposed to a diet high in isoflavones, a 4 mg/kg daily bolus of supplemental Se as methylselenocysteine (MSC), or the combination of high isoflavones and MSC starting at one of two time points: conception or 6 weeks of age, and were killed and dissected for prostate tissue, liver, and serum at either 4 weeks or 12 weeks of age (n per dietary treatment = 20: total mice = 240). Treatment with MSC resulted in decreased urogenital tract weight at 4 and 12 weeks. Treatment with MSC and isoflavones, both individually and as a combination, resulted in decreased androgen receptor expression, 5 alpha-reductase levels, and aromatase levels. The combination of MSC and a basal diet high in isoflavones resulted in decreased serum IGF-1 levels in 12 week TRAMP mice. Treatment from conception resulted in greater decreases in urogenital tract weight, 5 alpha-reductase expression, and aromatase expression than treatment from 6 weeks. This study demonstrated that in 12 week TRAMP mice, reductions in risk factors for prostate cancer by treatments of high isoflavones and supplemental Se are maximized by introduction to treatments at conception.

Quiner, Trevor Elisha. "Chemopreventive Effects of Dietary Selenium and Soy Isoflavones in a Mouse Model of Prostate Cancer." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2541.

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Prostate cancer is the most commonly diagnosed non-skin cancer in men and the second leading cause of cancer death in the United States. Prostate cancer, like many cancers, is a disease that generally requires a long period of time to develop and grow before it becomes detectable. This long period of latency makes prostate cancer a candidate for dietary chemoprevention. Soy and selenium (Se), are associated with a decreased risk of prostate cancer. We previously showed that high dietary intake of selenium (Se) and soy isoflavones decreased the expression of the androgen receptor (AR) and AR-regulated genes in the prostates of healthy rats. In this study we hypothesized that the downregulation of AR and AR-regulated genes would inhibit tumorigenesis in the transgenic adenocarcinoma of the mouse prostate (TRAMP) mouse. Mice were fed one of two stock diets with or without a supplement of Se in a 2 X 2 factorial design. The stock diets provided high or low dietary isoflavones. Mice were exposed to the diets from conception and sacrificed at 18 or 24 weeks of age. Prostate histopathology, urogenital tract (UGT) weight, serum IGF-1 levels, and the expression of AR and AR-regulated genes in the dorsolateral prostate was examined using quantitative PCR and Western blotting. Urogenital tract (UGT) weight was reduced compared to control in all dietary groups containing high Se, isoflavones, or both at 24 weeks (p<0.005). Dietary isoflavones delayed tumor progression and downregulated protein levels of AR, AR-regulated genes, and upregulated the protective FOXO1 and FOXO3a transcription factors. High dietary isoflavones also decreased the phosphorylation of the IGF-1R. The only main effect of Se was the upregulation of AKR1C14 the enzyme that deactivates 5&aplha;-DHT.This study identifies a previously unknown effect of isoflavones in the upregulation of FOXO expression and confirms previous studies of isoflavones' anticancer effects. Further research is needed to find a protective dose or form of Se and to elucidate the mechanism of isoflavones.

Васильченко, Вікторія Олексіївна. "Рецепція травми у збірці малої прози Наріне Абгарян “Дальше жить”". Магістерська робота, 2021. https://dspace.znu.edu.ua/jspui/handle/12345/6588.

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Васильченко В. О. Рецепція травми у збірці малої прози Наріне Абгарян “Дальше жить” : кваліфікаційна робота магістра спеціальності 035 «Філологія» / наук. керівник І. Я. Павленко. Запоріжжя : ЗНУ, 2021. 51 с.
RU : Основной текст квалификационной работы магистра «Рецепция травмы в сборник малой прозы Наринэ Абгарян “Дальше жить”» содержит 45 страниц. Для выполнения работы изучено 43 источников. Объект исследования ‒ сборник малой прозы Наринэ Абгарян “Дальше жить”. Цель исследования ‒ проанализировать специфику художественной рецепции травмы в сборник малой прозы Наринэ Абгарян “Дальше жить”. В ходе исследования предполагается решить следующие задачи: 1) проанализировать подходы к проблеме травмы в современном гуманитарном дискурсе; 2) выявить специфику студий травмы в литературоведческом дискурсе; 3) охарактеризовать факторы, повлиявшие на характер рецепции травмы в анализируемом сборнике; 4) обозначить индивидуально - авторское видение травмы и охарактеризовать характер ее рецепции на разных структурных уровнях сборника. Источниками исследования послужили текст сборника малой прозы Наринэ Абгарян “Дальше жить”, научны работы, монографии и статьи, посещённые проблемам травмы и памяти, литературоведческие словари. Методы исследования ‒ проблема исследуется с помощью описательного метода. Практическая значимость ‒ материалы работы могут быть использованы при изучении проблемы травмы в художественной литературе, на практических занятиях по современной военной и исторической прозе и на занятиях, посвященных проблеме травмы в произведениях. Апробация работы ‒ результаты исследования были представлены на Всеукраинской научной конференции «Запорізькі філологічні читання», ЗНУ 11-12.11.2021 г.; тема доклада ‒ «След войны: особенности структурной организации сборника малой прозы Наринэ Абгарян “Дальше жить”».
EN : The main text of the master's qualification work "Reception of trauma in Narine Abgaryan’s collection of flash fictions “Дальше жить”" contains 45 pages. To carry out the work, 43 sources were studied. The object of the research is collection of flash fictions “Дальше жить” written by Narine Abgaryan. The purpose of the research is to analyze the specifics of artistic perception of trauma in Narine Abgaryan’s collection of flash fictions “Дальше жить”. In the course of the study, it is supposed to solve the following tasks: 1) analyze approaches to the problem of trauma in modern humanitarian discourse; 2) reveal the specifics of trauma studios in literary discourse; 3) describe the factors that influenced the nature of the reception of trauma in the collection of flash fictions “Дальше жить”; designate the individual author's vision of trauma and characterize the nature of its reception at different structural levels of the collection. The sources of the research were the text of the Narine Abgaryan’s collection of flash fictions “Дальше жить”, scientific works, monographs and articles on the problems of trauma and memory, literary dictionaries. Research methods – descriptive. Practical significance - materials of the research can be used in the study of the problem of trauma in fictions and literature, at practical classes on modern military and historical prose. Approbation of the work - the results of the study were presented at the All-Ukrainian scientific conference «Запорізькі філологічні читання», ZNU 11-12.11.2021 г.; the topic of the report is «“Trace of the War: Features of the Structural Organization of Narine Abgaryan’s Abgaryan’s collection of flash fictions “Дальше жить”».

Bell, Joshua. "Dysfunctional AMPA Receptor Trafficking in Traumatic Brain Injury." Thesis, 2010. http://hdl.handle.net/1807/24681.

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Traumatic brain injury (TBI) is a devastating public health problem for patients and their families. The neurodegeneration that follows TBI is complex, but can be broadly subdivided into primary and secondary damage. Though primary damage is irreversible and therefore unsalvageable, extensive literature aimed at understanding the tissue, cellular, inflammatory and subcellular processes following the injury have proven unequivocally that secondary pathophysiological events are delayed and progressive in nature. Understanding these secondary events at the cellular levels is critical in the eventual establishment of targeted therapeutics aimed at limiting progressive injury after an initial trauma. One such secondary event is referred to in the literature as excitotoxicity; a sustained and de-regulated activation of glutamate receptors that leads to rapid cytotoxic edema and calcium overload. Our understanding of excitotoxicity has evolved to include not only a role for elevated extracellular glutamate in mediating neuronal damage, but also post-synaptic receptor modifications that render glutamate profoundly more toxic to injured neurons than healthy tissue. In this thesis, we explored the hypothesis that glutamate excitotoxicity can be perpetuated by trauma-induced post-synaptic modification of the AMPA receptor. Specifically, we used a cortical culture model of TBI as well as the fluid percussion injury device to test the hypothesis that TBI confers a reduction of surface GluR2 protein, an AMPA receptor subunit that limits neuronal calcium permeability. We conjectured that this decrease in the expression of surface GluR2 would increase the expression of calcium-permeable AMPA receptors, thereby rendering neurons vulnerable to secondary excitotoxic injury. We further investigated the subcellular mechanisms responsible for the internalization of surface GluR2, and the phenotypic consequences of GluR2 endocytosis in both models. Our data revealed that both models of TBI resulted in a regulated signaling cascade leading to the phosphorylation and internalization of GluR2. By exogenously interrupting the trafficking of GluR2 protein with an inhibitory peptide, we further observed that GluR2 internalization was mediated by a protein interaction involving protein interacting with C kinase 1 (PICK1) and protein kinase C alpha (PKCα), two PDZ domain-containing proteins that mediate GluR2 trafficking during constitutive synaptic plasticity. We observed that GluR2 endocytosis was NMDA receptor dependent, and resulted in increased neuronal calcium permeability, augmented AMPA receptor-mediated electrophysiological activity and increased susceptibility to delayed cell death. Finally, we demonstrated that the interruption of GluR2 trafficking is cytoprotective, suggesting that sustaining surface GluR2 protein protects neurons against secondary injury. Overall, our findings suggest that experimental TBI promotes the expression of injurious GluR2-lacking AMPA receptors, thereby enhancing cellular vulnerability to secondary excitotoxicity.

Книги з теми "Reception of trauma":

Santini, Daria. Wohin verschlug uns der Traum?: Die griechische Antike in der deutschsprachigen Literatur des Dritten Reichs und des Exils. Frankfurt am Main: P. Lang, 2007.

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Wales Freedman, Eden. Reading Testimony, Witnessing Trauma. University Press of Mississippi, 2020. http://dx.doi.org/10.14325/mississippi/9781496827333.001.0001.

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Reading Testimony, Witnessing Trauma: Confronting Race, Gender, and Violence in American Literature treats reader response to traumatic and testimonial literature written by and about African American women. Theorists emphasize the necessity of writing about—or “witnessing”—trauma to overcome it. To this critical conversation, Reading Testimony, Witnessing Trauma adds insight into the engagement of testimonial literature, articulating a theory of reading (or “dual-witnessing”) that explores how narrators and readers can witness trauma together. The book then places its original theories of traumatic reception in conversation with the African American literary tradition to speak to the histories, cultures, and traumas of African Americans, particularly the repercussions of slavery, as witnessed in American literature. This book also considers intersections of race and gender and how narrators and readers can cross such constructs to witness collectively. Reading Testimony, Witnessing Trauma’s innovative examinations of raced-gendered intersections open and speak with those works that promote dual-witnessing through the fraught (literary) histories of race and gender relations in America. To explicate how dual-witnessing converses with American literature, race theory, and gender criticism, the book analyzes emancipatory narratives by Sojourner Truth, Harriet Jacobs, and Elizabeth Keckley and novels by William Faulkner, Zora Neale Hurston, Margaret Walker, Toni Morrison, and Jesmyn Ward.

Trezise, Thomas. Witnessing Witnessing: On the Reception of Holocaust Survivor Testimony. Fordham University Press, 2013.

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Trezise, Thomas. Witnessing Witnessing: On the Reception of Holocaust Survivor Testimony. Fordham University Press, 2013.

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Kelle, Brad E., and Brent A. Strawn, eds. The Oxford Handbook of the Historical Books of the Hebrew Bible. Oxford University Press, 2020. http://dx.doi.org/10.1093/oxfordhb/9780190261160.001.0001.

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The Oxford Handbook of the Historical Books of the Hebrew Bible offers thirty-six essays on the so-called “Historical Books”: Joshua, Judges, 1–2 Samuel, 1–2 Kings, Ezra-Nehemiah, and 1–2 Chronicles. The essays are organized around four nodes: contexts, content, approaches, and reception. Each essay takes up two questions: (1) what does the topic/area/issue have to do with the Historical Books? and (2) how does this topic/area/issue help readers better interpret the Historical Books? The essays engage traditional theories and newer updates to the same, and also engage the textual traditions themselves which are what give rise to compositional analyses. Many essays model approaches that move in entirely different ways altogether, however, whether those are by attending to synchronic, literary, theoretical, or reception aspects of the texts at hand. The contributions range from text-critical issues to ancient historiography, state formation and development, ancient Near Eastern contexts, society and economy, political theory, violence studies, orality, feminism, postcolonialism, and trauma theory—among others. Taken together, these essays well represent the variety of options available when it comes to gathering, assessing, and interpreting these particular biblical books.

de Rond, Mark. Doctors at War. Cornell University Press, 2017. http://dx.doi.org/10.7591/cornell/9781501705489.001.0001.

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This book is a candid account of a trauma surgical team based, for a tour of duty, at a field hospital in Helmand, Afghanistan. It tells of the highs and lows of surgical life in hard-hitting detail, bringing to life a morally ambiguous world in which good people face impossible choices and in which routines designed to normalize experience have the unintended effect of highlighting war's absurdity. With stories that are at once comical and tragic, the book captures the surreal experience of being a doctor at war. It lifts the cover on a world rarely ever seen, let alone written about, and provides a poignant counterpoint to the archetypical, adrenaline-packed, macho tale of what it is like to go to war. Here the crude and visceral coexist with the tender and affectionate. The book tells of well-meaning soldiers at hospital reception, there to deliver a pair of legs in the belief that these can be reattached to their comrade, now in mid-surgery; of midsummer Christmas parties and pancake breakfasts and late-night sauna sessions; of interpersonal rivalries and banter; of caring too little or too much; of tenderness and compassion fatigue; of hell and redemption; of heroism and of playing God. This is one of the first books ever to bring to life the experience of the doctors and surgical teams tasked with mending what war destroys.

Santini, Daria. Wohin Verschlug Uns Der Traum? (Studien Zur Klassischen Philologie). Peter Lang Publishing, 2006.

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Hendrickson, Rebecca C., and Murray A. Raskind. Pharmacological Treatment of Nightmares, Sleep Disturbance, and Daytime Hyperarousal in PTSD: The Role of Prazosin, Other Noradrenergic Modulators, and Sedative Hypnotics or Commonly Used Sedating Medications. Edited by Charles B. Nemeroff and Charles R. Marmar. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190259440.003.0035.

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Disruption of stress-response systems contributes to the pathophysiology of post-traumatic stress disorder (PTSD). Consistent with this, daytime hyperarousal and nighttime sleep disruption, including trauma-related nightmares, are core symptoms of the disorder, often requiring targeted pharmacologic treatment. Although a variety of medications that target sleep–wake and arousal mechanisms are commonly used for this purpose, there remains the best empirical support for prazosin, a brain-active antagonist of the α‎1 noradrenaline receptor, with emerging evidence for doxazosin, a longer-acting medication with the same mechanism of action. This chapter reviews the evidence for use of prazosin and doxazosin as well as for the sedative hypnotics (benzodiazepines, nonbenzodiazepine hypnotics, and related medications), antihistamines, and sedating antidepressants trazodone and nefazodone to address hyperarousal symptoms and trauma-associated nightmares in PTSD. Clinical recommendations for the use of prazosin in PTSD, as well as a discussion of emerging pharmacologic treatments, are also included.

Dahl, Vegard, and Ulrich J. Spreng. Anaesthesia for non-obstetric surgery. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0010.

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Anaesthesia for non-obstetric reasons is performed in 1–2% of all pregnant women. Although the chances of complications like miscarriage, preterm labour, and abortion are higher when surgery is performed during gestation, careful evaluation, preparation, and a multidisciplinary approach will minimize these risks. There are no methods of anaesthesia that are preferable to others during pregnancy. The most important preventive measure is to maintain maternal haemodynamic stability and normoventilation in order to ensure fetal well-being. Extensive knowledge of the profound anatomical and physiological changes that a pregnancy induces is mandatory for the team when operating on a pregnant woman. Short time exposure to anaesthetic agents in clinically relevant doses during surgery has never been demonstrated to have teratogenic effects. Lately, focus has been made on the possible behavioural teratogenic properties of anaesthesia, especially on the use of NMDA receptor antagonists and GABA receptor agonists. Emergency diagnostic imaging during pregnancy is considered safe and should be performed if necessary. Electroconvulsive therapy for the treatment of serious psychiatric disorders during pregnancy is a possibility that should be considered if necessary. Electric cardioversion seems safe for the fetus if life-threatening arrhythmias occur during pregnancy. Trauma is one of the leading non-obstetric causes of maternal mortality and morbidity. When treating a traumatized pregnant woman one should initially focus on the mother’s safety and haemodynamic stability.

Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Amsterdam: Elsevier, 1996.

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Частини книг з теми "Reception of trauma":

Theisen-Womersley, Gail. "Collective Aspirations." In Trauma and Resilience Among Displaced Populations, 195–208. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67712-1_8.

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AbstractEurope has faced an unprecedented influx of asylum seekers– with over one and a half million sea arrivals reported since 2015 by the United Nations High Commissioner for Refugees (UNHCR). As the “reception crisis” continues unabated, Greece remains one of the first ports of sanctuary. According to recent statistics provided for March 2018 by the UNHCR, over 50,000 asylum seekers and refugees currently remain in Greece following this mass flow.

Salpeter, M. M. "Acetylcholine Receptor Turnover Rates at Innervated and Denervated Vertebrate Neuromuscular Junctions." In Processes of Recovery from Neural Trauma, 189–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70699-8_16.

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Cocanour, C. S., F. M. Orson, D. Thomas, and S. Rich. "Transforming Growth Factor β1 Upregulates the Interleukin-2 Receptor α Promoter." In Host Defense Dysfunction in Trauma, Shock and Sepsis, 629–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77405-8_80.

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Fletcher, J. R., J. A. Moore, A. G. DiSimone, N. Abumerad, P. Williams, J. Pollard, J. Collins, and E. Graves. "Potential Benefits of Platelet Activating Factor Receptor Antagonists in Endotoxemia/Sepsis." In Host Defense Dysfunction in Trauma, Shock and Sepsis, 1229–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77405-8_159.

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Dinarello, C. A. "Interleukin-1-Induced Hypotension and the Effect of an Interleukin-1 Receptor Antagonist." In Host Defense Dysfunction in Trauma, Shock and Sepsis, 571–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77405-8_72.

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Nolte, D., H. A. Lehr, and K. Messmer. "Adenosine Inhibits Postischemic Leukocyte Adherence to the Endothelium of Postcapillary Venules via A2 Receptor." In Host Defense Dysfunction in Trauma, Shock and Sepsis, 399–402. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77405-8_45.

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Taya, Keisuke, Salih Gulsen, Kenji Okuno, Ruth Prieto, Christina R. Marmarou, and Anthony Marmarou. "Modulation of AQP4 expression by the selective V1a receptor antagonist, SR49059, decreases trauma-induced brain edema." In Acta Neurochirurgica Supplements, 425–29. Vienna: Springer Vienna, 2008. http://dx.doi.org/10.1007/978-3-211-85578-2_83.

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Sharma, Hari Shanker. "A Bradykinin BK2 Receptor Antagonist HOE-140 Attenuates Blood-Spinal Cord Barrier Permeability Following a Focal Trauma to the Rat Spinal Cord." In Brain Edema XI, 159–63. Vienna: Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6346-7_32.

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Wales Freedman, Eden. "Introduction." In Reading Testimony, Witnessing Trauma, 3–40. University Press of Mississippi, 2020. http://dx.doi.org/10.14325/mississippi/9781496827333.003.0001.

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The introduction explicates theories of dual-witnessing and Venn liminality and introduces the reader to the terminology the author developed to address readerly engagement of (African) American traumatic and testimonial literature. The introduction also explains how the author’s modes of reading trauma intersect with American literature, critical race theory, and gender criticism and unpacks what (and how) this Venn conversation contributes to the fields of trauma, race, gender, and reception studies and (African) American literature.

"Beyond The Limits of Art and War Trauma David Jones’s ‘In Parenthesis’." In Classics in Extremis : The Edges of Classical Reception. Bloomsbury Academic, 2019. http://dx.doi.org/10.5040/9781350017283.ch-009.

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Тези доповідей конференцій з теми "Reception of trauma":

Kopenkin, A., E. Grigoricheva, D. Kopyonkin, E. Elsukova, E. Kalugina, M. Samoplavsky, Yu Shamurova, et al. "Benign paroxysmal positional vertigo in differential diagnosis of traumatic brain injury trauma surgeon and otorhinolaringologist physician at ambulatory reception." In MECHANICS, RESOURCE AND DIAGNOSTICS OF MATERIALS AND STRUCTURES (MRDMS-2020): Proceeding of the 14th International Conference on Mechanics, Resource and Diagnostics of Materials and Structures. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0036703.

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Bagchi, A., F. Nagashima, A. Hindle, and F. Ichinose. "RNA Sequencing Identifies Peroxisome Proliferator-Activated Receptor-Gamma Upregulation as an Immunomodulator in a 'Two-Hit' Mouse Model of Trauma Followed by Acute Lung Injury." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2620.

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P. Robles Balestero, Juan, and Sérgio Kurokawa. "Linhas de Transmissão com Cargas - Representação no Domínio Modal." In Simpósio Brasileiro de Sistemas Elétricos - SBSE2020. sbabra, 2020. http://dx.doi.org/10.48011/sbse.v1i1.2194.

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A representação de linhas de transmissão no domínio modal é amplamente conhecida. No entanto não se encontra na literatura nada referente ao comportamento das cargas, no domínio modal, conectadas no receptor de uma linha de transmissão. Neste artigo será mostrado como se dá a representação de linhas de transmissão, no domínio modal, considerando a presença de cargas conectadas em seus terminais. Os resultados mostram que cargas equilibradas com ou sem acoplamento mútuo podem ser representadas no domínio modal como sendo cargas monofásicas desacopladas que são conectadas no terminal receptor de cada modo de propagação da linha. Quando se trata de cargas desequilibradas verifica-se que as mesmas também são representadas por cargas monofásicas. No entanto, em se tratando de cargas desequilibradas, existe um acoplamento entre estas cargas monofásicas. O estudo realizado permite o entendimento de como linhas de transmissão com cargas são representadas, no domínio modal, em softwares que realizam simulações de transitórios eletromagnéticos em sistemas de energia elétrica (softwares do tipo ATP e EMTP).

Fischer, Nicolas, Patrick Martini, Mateus Tomaz, Patrick Priebe, Matheus Konrath, Maurício Konrath, Daniela Bagatini, and Daniela Peranconi. "Chatbot Iara: relacionando e interagindo com dados sobre o novo coronavírus em Santa Cruz do Sul." In I Escola Regional de Computação do Rio Grande do Sul. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/ercomprs.2020.14295.

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Percebendo a necessidade de mecanismos para facilitar a disseminação das informações, de forma simples, acerca da pandemia sobre o coronavírus em Santa Cruz do Sul, esse trabalho apresenta a Iara, um chatbot que relaciona dados quantitativos e informações de decretos municipais. O desenvolvimento do assistente ocorreu em três etapas: (1) Captação, curadoria e organização dos dados; (2) Planejamento das decisões e ações; (3) Construção do agente, inclusão dos dados e treinamento. O chatbot trata-se de um protótipo para identificar a aceitação de bots em sites, o qual já fornece uma visão receptiva a ações desencadeadas pelo bot, validando a proposta de relacionar e permitir que usuários interajam com dados públicos com unidade.

Montico, Fabio, and Pedro Augusto Marischka Mateus. "Celecoxib treatment negatively influences angiogenesis and androgen receptor distribution in the prostate of TRAMP mice: effects on prostatic adenocarcinoma progression ." In XXIII Congresso de Iniciação Científica da Unicamp. Campinas - SP, Brazil: Galoá, 2015. http://dx.doi.org/10.19146/pibic-2015-38265.

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Langer, Ieda Bernadete Volkweis, and TAINARA BOMBARDA. "CASOS CONFIRMADOS DE COVID-19: ASPECTOS CLÍNICOS E EPIDEMIOLÓGICOS REGISTRADOS EM UM MUNICÍPIO DO SUDOESTE DO PARANÁ." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6383.

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Introdução: A COVID-19 foi declarada como pandemia pela Organização Mundial de Saúde (OMS) em março de 2020. Trata-se de uma infecção respiratória aguda causada por um novo coronavírus, denominado SARS-CoV-2. A infecção oscila de quadros assintomáticos até a Síndrome Respiratória Aguda Grave (SRAG). O período de incubação normalmente é de 5 dias, oscilando entre 2 e 14 dias. Os olhos, nariz e boca são os principais acessos de entrada para o SARS-CoV-2 que alcança as células dos hospedeiros por afinidade ao receptor da enzima conversora de angiotensina 2 (ACE-2). A proteína S, presente nas espículas virais, é reconhecida pelo domínio ligante do receptor (RBD) do SARS-CoV-2. Assim o vírus liga-se à célula receptora, insere seu RNA e passa a produzir copias virais. Objetivo: Abordar aspectos clínicos e epidemiológicos da COVID-19. Material e métodos: No período de julho 2020 a junho de 2021, foram avaliadas fichas de notificações e monitoramento de casos de COVID-19, disponibilizadas pela Secretaria Municipal de Saúde do município de Nova Prata do Iguaçu-PR. Resultados: As notificações somaram um total de 2603 sendo 1081 casos confirmados. Indivíduos entre 40 a 49 anos de idade, do gênero feminino foram os mais atingidos com diagnóstico confirmado pelo exame de biologia molecular (PCR) 81,5% e testes imunológicos 18,49%. Grande parcela dos envolvidos acometidos, pertence a algum grupo de risco, havendo um predomínio para portadores de comorbidades (20,20%), idosos (13,92%) e fumantes (6,96%). Conclusão: O conhecimento de aspectos clínicos e epidemiológicos da doença são importantes para o planejamento, elaboração e adoção de medidas de controle junto à população. Sendo assim, mudanças de comportamento, tanto individuais quanto coletivas, aliadas a vacinação em massa, são necessárias para que haja a interrupção controlada e sustentada da cadeia de transmissão.

Mombelli, Janaina Maria Rodrigues, Daniele De Oliveira Gomes, and Marli Teresinha Cassamassimo Duarte. "ASSISTÊNCIA DE ENFERMAGEM AO PACIENTE COM LINFOMA DE HODGKIN SUBMETIDO AO TRANSPLANTE DE MEDULA ÓSSEA: UM RELATO DE EXPERIÊNCIA." In II Congresso Nacional Multidisciplinar em Enfermagem On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2513.

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Introdução: O Linfoma de Hodgkin é um câncer originado nos linfonodos do sistema linfático, dividido em Linfoma de Hodgkin (LH) e Linfoma Não Hodgkin (LNH) - baseado na presença de células Reed-Stenberg (RS) no LH. A maior parte dos casos de LH, ocorre quando a célula de defesa, linfócito B, desenvolve uma mutação em seu DNA. Acomete com maior frequência adultos jovens, 20 a 34 anos. Representa 19% dos casos de linfoma no Brasil e 10% dos linfomas no mundo.O Transplante de Medula Óssea é um processo de substituição da medula óssea doente ou lesada por uma medula óssea com função normal. Consiste na infusão, por via intravenosa, de sangue de medula óssea de um doador previamente selecionado a um receptor adequadamente condicionado. De acordo com a Sociedade Brasileira de TMO, há 3 tipos: 1. autogênico/autólogo: as células são do próprio paciente, 2. alogênico: doador e receptor são pessoas diferentes mas compatíveis, 3. singênico: as células são obtidas de um irmão gêmeo idêntico (homozigoto/univitelino), sendo perfeitamente compatíveis, com menores complicações, porém de incidência rara. Objetivo: Relatar um caso clínico a respeito da assistência de enfermagem a um paciente com Linfoma de Hodgkin, submetido ao TMO. Material e Métodos: Trata-se de um estudo qualitativo, do tipo relato de caso. Os dados utilizados foram coletados a partir da entrevista e exame físico de enfermagem, anotações em prontuário eletrônico e revisão da literatura. Resultados: Paciente de 33 anos, sexo feminino, internação eletiva na Enfermaria de Transplantes do Hospital das Clínicas de Botucatu, para realização de Condicionamento LACE e posterior TMO Autólogo. Foram elencados diagnósticos de enfermagem, como “Integridade da membrana mucosa oral prejudicada relacionado a quimioterapia evidenciado por hiperemia”, e suas respectivas intervenções e resultados esperados. Conclusão: Durante a assistência e as buscas na literatura, foi possível perceber que o enfermeiro tem um papel essencial no transplante de medula óssea, estando presente do início ao fim da infusão, avaliando o estado geral a cada instante e dando o suporte necessário. É um procedimento que requer conhecimento científico, destreza no manuseio da bolsa e dos materiais, além de uma escuta terapêutica.

Sobral, Rodrigo, Janderley José De Matos, Umberto Pereira Souza Junior, and Giani Maria Cavalcante. "UTILIZAÇÃO DA CANNABIS SATIVA NO MANEJO DO ESTRESSE EM PORTADORES DE SINDROME DO INTESTINO IRRITÁVEL: UMA REVISÃO DA LITERATURA." In III Congresso Brasileiro de Ciências Farmacêuticas On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/conbracif/41.

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Introdução: A síndrome do intestino irritável (SII) é um distúrbio gastrointestinal crônico e remitente caracterizado por: dor abdominal, constipação ou diarreia, inchaço e flatulências. Sua fisiopatologia ainda é incompreendida, mas se dá provavelmente devido a interações complexas entre os sistemas imunológico, hormonal e nervoso. Diversos fatores são apontados como precursores, dentre eles, o estresse psicológico, que além de desestabilizar o equilíbrio e a homeostase do organismo, podem alterar as interações cérebro-intestino, afetando diferentes funções fisiológicas do sistema gastrointestinal. Muitas medidas são utilizadas para proporcionar alívio dos sintomas como o uso de medicamentos, alguns antidepressivos tricíclicos e ansiolíticos, contudo tais medidas são paliativas pois se trata de uma patologia crônica. Com o advento da ciência e a flexibilização das leis no que tangem o uso dos derivados da Cannabis sativa, muitas substâncias ativas, como por exemplo o canabidiol (CBD), são apontadas como recursos com menos efeitos colaterais e altamente eficazes nos tratamentos de diversas patologias, incluindo os distúrbios da ansiedade e estresse, sendo um importante recurso a ser considerado. Objetivo: Avaliar a eficácia da Cannabis sativa no manejo do estresse em portadores da síndrome do intestino irritável. Material e métodos: Revisão da literatura científica, apoiada em artigos indexados nas bases “Pubmed” e “Google Acadêmico”, utilizando os descritores: Estresse, Cannabis sativa, Canabidiol, Síndrome do Intestino Irritável, sendo selecionados 07 artigos originais. Como critério de inclusão, os artigos deveriam ter sido publicados entre 2016 e 2021, sendo excluído, os resumos e resumos expandidos. Resultados: A eficácia da Cannabis sativa, no manejo da SII, se dá principalmente pelos seus constituintes ativos dos quais o Canabidiol (CBD), é um de seus componentes mais estudados e com propriedades farmacológicas comprovadas frente a ansiedade e o estresse, pois tem uma afinidade com os receptor serotoninérgico 5-HT1A e o receptor CB1, e é bem conhecido que os receptores serotoninérgicos 5-HT desempenham um papel crítico na alteração relacionada ao estresse da motilidade intestinal, sensibilidade visceral e secreção intestinal, e também na fisiopatologia de distúrbios como SII. Conclusão: Por sua ação ansiolítica, é um recurso interessante no manejo do estresse e desordens emocionais, considerados fatores de agravo do quadro de SII.

Gupta, Vivek, Amita Mishra, Namit Kalra, and Bhawna Narula. "A rare case report of incidental solitary uterine metastasis in primary invasive lobular carcinoma of breast." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685401.

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Introduction: Infiltrating Lobular carcinoma (ILC) of the breast is second most common cancer of breast next only to Infiltrating ductal carcinoma (IDC). It has a different metastatic pattern as compared to the IDC. Breast cancer is the most frequent primary site which spreads to gynaecologic organs. Case Presentation: A 40 yrs old Iraqi lady presented as a diagnosed case of lobular carcinoma of left breast. She had already undergone a lumpectomy at Iraq a month back and now had come for completion of treatment. On metastatic workup with PETCT scan, we found a multicentric residual disease in the left breast along with some ipsilateral axillary LN with significant uptake. The concurrent CECT done showed a uterine leiomyomam also. As she was strongly hormone receptor positive, had completed her family and was having mennorhagia probably attributable to uterine fibroids. She was offered hysterectomy with B/L salpingo-oophorectomy. She was keen for breast preservation but in view of her multicentricity of disease on the left breast she was counselled for mastectomy with upfront whole breast reconstruction with TRAM flap. She underwent left modified radical mastectomy with hysterectomy with BSO and TRAM flap reconstruction. The histopathological examination revealed a multicentric, multifocal ILC, grade II with heavy nodal involvement including extracapsular extension. The leiomyoma of uterus also showed tumor deposits from lobular carcinoma breast. Conclusion: We report a very rare case of metastatic pattern of carcinoma of breast. On literature review we found that it is common for the lobular carcinomas of breast to metastasise to gynaecologic organs. Uterine corpus is a very rare site of metastasis for extragenital cancers including breast. All the patients of primary lobular carcinoma of breast should be screened for gynaecologic secondaries in the preoperative workup with high degree of suspicion.

Oliveira, Kathllyn Joyce De Jesus, and João Ronaldo Tavares De Vasconcellos Neto. "A INSERÇÃO DE VITAMINA D NO TRATAMENTO DE DOENÇAS AUTOIMUNES." In I Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1001.

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INTRODUÇÃO: As doenças autoimunes representam reações imunes exacerbadas direcionadas a autoantígenos, devido à ausência de mecanismos destinados a autotolerância. Ao longo das últimas décadas, a prevalência destas patologias apresenta elevadas proporções principalmente em mulheres, devido a condições hormonais. OBJETIVOS: Determinar a relação entre a concentração de vitamina D e o desenvolvimento de doenças autoimunes. MATERIAIS E MÉTODOS: Trata-se de uma revisão de literatura realizada a partir do banco de dados PubMed, entre os anos de 2019 e 2021, através dos descritores Vitamin D Deficiency e Autoimmune Diseases. RESULTADO: Os pacientes com doenças autoimunes geralmente possuem a hipovitaminose D. As células do sistema imunológico expressam o receptor de vitamina D, desse modo, o composto lipossolúvel descrito exerce a modulação do sistema imune, possui ação antiinflamatória e contribui para o aumento de linfócitos T regulatórios, capazes de limitar a resposta imune. A vitamina D quando introduzida via ingestão de alimentos de origem animal, torna-se susceptível a consecutivas reações químicas de hidroxilação no organismo humano, presentes tanto a nível renal como hepático. Cabe ressaltar também, que a forma ativa designada como calcitriol, suprime a ação da resposta Th1, associada a interferon gama e interleucinas, induz a ação de linfócitos auxiliares 2, além disso, contempla características antioxidante, assim como antifibrótica. CONCLUSÃO: Estudos estabelecem relação direta entre insuficiência de vitamina D e progressão de doenças autoimunes. A adesão de níveis séricos adequados desta substância através da suplementação ou exposição solar, consiste em um recurso com baixo custo de saúde pública e acessível para tratar ou prevenir as doenças autoimunes.