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Дисертації з теми "Receptor-ligand complexes"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 26 липня 2024

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1

Patel, Amesh Babubhai. "Biophysical and computational investigations into receptor-ligand complexes." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435998.

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2

Wang, Xiang. "Computational studies of melanocortin receptor system and channel function in glutamine-dependent amidotransferases." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001072.

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3

Bishop, Benjamin F. "Structural and functional characterisation of hedgehog ligand-receptor complexes." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642625.

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Members of the Hedgehog (HH) family of morphogenic signalling molecules are key mediators of many fundamental processes in embryonic development. A relatively small change in HH concentration results in the specification of distinct cell types. Such fine-tuning necessitates a range of regulatory cell-surface proteins to control the concentration of HH to which responding cells are exposed. This thesis focuses on the structural and functional characterisation of three human extracellular modulators of the HH pathway, namely the hedgehog-interacting protein HHIP, the glypican GPC3 and the Growth

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4

Coonan, Jason R. "Regulation of neural connectivity by the EphA4 receptor tyrosine kinase /." Connect to thesis, 2001. http://eprints.unimelb.edu.au/archive/00000727.

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5

Nahas, Roger I. "Synthesis and structure-activity relationship of a series of sigma receptor ligands." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4840.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on February 26, 2008) Vita. Includes bibliographical references.

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6

Read, Stuart Hamilton. "Production and function of a soluble c-Kit molecule." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phr2845.pdf.

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"Research conducted at the Department of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science."--T.p. Includes bibliographical references (leaves 170-214). Elevated levels of receptor tyrosine kinases have been implicated in carcinogenesis. It is possible that high expression of c-Kit by the leukaemic cell provides them with a growth advantage over their normal counterparts in the bone marrow microenvironment. Thus, a means of inhibiting the interaction of c-Kit on these cells with ligand Steel Factor may remove proliferation and survival signals. Main ai

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7

Lengqvist, Johan. "Native protein mass spectrometry of nuclear receptor-ligand and enzyme-substrate complexes /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-116-4/.

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8

Smith, Mark Edward. "Molecular wires : syntheses, electrochemistry and properties of metal complexes containing carbon chains /." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phs654.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2002.<br>"September 2002" Includes as appendix: a list of publications by the author arising from this work; and, copies of some published journal articles. Includes bibliographical references.

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9

Yamamoto, Izumi. "Structure-function studies of GABA-C receptor ligands." Thesis, The University of Sydney, 2012. https://hdl.handle.net/2123/28927.

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Throughout the central nervous system (CNS), the Cys-loop superfamily of ligand-gated ion channels {LGICs), including nicotinic acetylcholine, serotonin type-3A, strychnine-sensitive glycine and y-aminobutyric acid A/C receptors, play important roles in synaptic transmission by converting chemical signals into electric signals. Designing potent and subtype-selective ligands with therapeutic value requires knowledge about how ligands interact with their binding sites. y-Aminobutyric acid (GABA) is the predominant inhibitory neurotransmitter in the mammalian CNS and its binding modes at GABA r

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10

Nervall, Martin. "Binding Free Energy Calculations on Ligand-Receptor Complexes Applied to Malarial Protease Inhibitors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8338.

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11

Jiang, Ning. "Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands". Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/26716.

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Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated yet powerful tool. Results revealed an unusual temperature dependence of reverse rate of CD16aTM dissociating from IgG. Except for a few studies using mammalian cell CD16s, most kinetics analyses use purified aglycosylated extracellular portion of the molecules, making it impossible to assess the impor

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12

Almlöf, Martin. "Computational Methods for Calculation of Ligand-Receptor Binding Affinities Involving Protein and Nucleic Acid Complexes." Doctoral thesis, Uppsala University, Department of Cell and Molecular Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7421.

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<p>The ability to accurately predict binding free energies from computer simulations is an invaluable resource in understanding biochemical processes and drug action. Several methods based on microscopic molecular dynamics simulations exist, and in this thesis the validation, application, and development of the linear interaction energy (LIE) method is presented.</p><p>For a test case of several hydrophobic ligands binding to P450cam it is found that the LIE parameters do not change when simulations are performed with three different force fields. The nonpolar contribution to binding of these

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13

Almlöf, Martin. "Computational methods for calculation of Ligand-Receptor binding affinities involving protein and nucleic acid complexes /." Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7421.

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14

Yuan, Xiaohui. "Characterization of the ligand-binding specificity and transcriptional properties of estrogen receptor homodimeric/heterodimeric complexes." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3036871.

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15

Roulston, Carli L. (Carli Lorraine) 1973. "Localization of both type 2 angiotensin II receptors and a non-angiotensin II binding site by [125 I] CGP42112 in rat brain stem." Monash University, Dept. of Pharmacology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8844.

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16

Proctor, Lavinia M. "Pharmacological activity of C3a and C3a receptor ligands /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18423.pdf.

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17

Love, James Daniel. "Structural and functional studies of the nuclear retinoid-X-receptor and complexes with ligand, retinoic acid receptor and co-repressor proteins." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620208.

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18

Griswold, Ian James. "The structural role of CheW in the bacterial chemotaxis receptor complex /." view abstract or download file of text, 2001. http://wwwlib.umi.com/cr/uoregon/fullcit?p3018365.

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Анотація:

Thesis (Ph. D.)--University of Oregon, 2001.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 163-175). Also available for download via the World Wide Web; free to University of Oregon users.

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19

Tolentino, Timothy P. "The Roles of Membrane Rafts in CD32A Mediated Formation of a Phagocytic Contact Area." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16127.

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Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to facilitate the functions of these molecules such as membrane trafficking, receptor transport, cell signaling, and endocytosis. Using laser scanning confocal microscopy and reflection interference microscopy (RIM), we studied the spatial and temporal distributions of membrane rafts and surface receptors, signaling molecules, and cell organelles during t

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20

Yavrom, Sheena. "Evidence that ARNT plays a role in the regulation of the immunoglobulin heavy chain enhancer and identification of a putative ARNT ligand." Scholarly Commons, 1998. https://scholarlycommons.pacific.edu/uop_etds/516.

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Basic helix-loop-helix (bHLH) proteins are involved in the regulation of a multitude of developmental processes including cellular differentiation, cellular proliferation and xenobiotic metabolism. Among the members of the bHLH protein family are the products of the Pan gene Pan-1, Pan-2 and ITF -1. Pan proteins have been demonstrated to be required for proper B cell development, suggesting a unique role for Pan proteins during B cell formation. In our study we tested the function of ARNT (Ah receptor nuclear translocator) at the IgH (immunoglobulin heavy chain) enhancer. We were able to deter

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21

Dogra, Navneet. "INVESTIGATING PROTEIN - BILAYER COMPLEXES: A STUDY OF LIGAND - RECEPTOR INTERACTIONS AT MODEL MEMBRANE SURFACE BY USING ELECTRONIC ABSORPTION SPECTROSCOPY AND FLUORESCENCE RESONANCE ENERGY TRANSFER." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/812.

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The main aim of work presented here is to design, develop and characterize a colorimetric model membrane (liposome) systems, which can bind with proteins, enzymes, bacteria, virus and other biomolecules. PDA molecules are utilized as a scaffold for the bilayer membrane, and a colorimetric assay is carried out. The holy grail of present work contributes towards the better understanding of protein interactions with the cell bilayer surface. Chapter 1 introduces a brief history on the advent of bilayer systems for cellular research exploration. We presented a literature survey about how liposom

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22

Ousley, Amanda. "Engineering the human vitamin D receptor to bind a novel small molecule: investigating the structure-function relationship between human vitamin d receptor and various ligands." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39580.

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The human vitamin D receptor (hVDR) is a member of the nuclear receptor superfamily, involved in calcium and phosphate homeostasis; hence implicated in a number of diseases, such as Rickets and Osteoporosis. This receptor binds 1α,25-dihydroxyvitamin D3 (also referred to as 1,25(OH)2D3) and other known ligands, such as lithocholic acid. Specific interactions between the receptor and ligand are crucial for the function and activation of this receptor, as implied by the single point mutation, H305Q, causing symptoms of Type II Rickets. In this work, further understanding of the significant an

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23

Chang, Cheng. "In silico approaches for studying transporter and receptor structure-activity relationships." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117553995.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 271 p.; also includes graphics. Includes bibliographical references (p. 245-269). Available online via OhioLINK's ETD Center

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24

Wilkinson, Tracey Nicole. "Evolutionary analysis of the relaxin peptide family and their receptors." Connect to thesis, 2006. http://repository.unimelb.edu.au/10187/2315.

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The relaxin-like peptide family consists of relaxin-1, 2 and 3, and the insulin-like peptides (INSL)-3, 4, 5 and 6. The evolution of this family has been controversial; points of contention include the existence of an invertebrate relaxin and the absence of a ruminant relaxin. Using the known members of the relaxin peptide family, all available vertebrate and invertebrate genomes were searched for relaxin peptide sequences. Contrary to previous reports an invertebrate relaxin was not found; sequence similarity searches indicate the family emerged during early vertebrate evolution. Phylogen

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25

Tondu, Sylvie. "Synthèse et étude biochimique d'hormones organométalliques : application à la détection du récepteur de la progestérone." Paris 6, 1986. http://www.theses.fr/1986PA066068.

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Synthèse de dérivés de métaux carbonyles d'hormones stéroïdes (progestatifs et glucocorticoïdes). Etude de l'affinité de ces produits pour les 2 récepteurs étudiés, avec sélection de 2 marqueurs potentiels. Spectrométrie IR.

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26

Van, Schoore Grégory. "Etude d'un récepteur orphelin apparenté aux récepteurs aux hormones glycoprotéiques, LGR4." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210545.

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Les récepteurs couplés aux protéines G (RCPG) sont impliqués dans la majeure partie des communications intercellulaires. Un grand nombre de RCPG ont été découverts en comparant la séquence des récepteurs connus avec les données fournies par le séquençage du génome humain. Pour plus d'une centaine de ces récepteurs, le ligand activateur ou agoniste est inconnu. Ces récepteurs sont dès lors qualifiés d'orphelins.<p>Les LGR forment une sous-famille de RCPG structurellement proches de la rhodopsine qui comprend les récepteurs aux hormones glycoprotéiques (TSH, LH, hCG, FSH) et à la relaxine. LGR4

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27

Montiel-Jorda, Álvaro. "Influence de la température sur la voie de signalisation des hormones brassinostéroïdes : mécanismes moléculaires et conséquences pour la croissance et le développement des plantes." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS447.

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La signalisation des brassinostéroïdes (BR) est importante pour presque tous les aspects du développement des plantes, comme en témoigne le phénotype extrêmement nain et stérile des mutants défectueux du récepteur des brassinostéroïdes BRASINOSTEROID INSENSITIVE 1 (BRI1). De plus, il est un régulateur clé de la réponse des plantes à l'augmentation de la température ambiante (thermomorphogenèse) dans les parties aériennes de la plante, associé à la signalisation auxine et au facteur de transcription PHYTOCHROME INTERACTING FACTOR 4 (PIF4). Cependant, les rôles des mécanismes moléculaires de la

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28

Pons, Mégane. "Vers un traitement de la maladie d'Alzheimer : synthèse de nouveaux ligands multi-cibles." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR082.

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La maladie d’Alzheimer (MA) est une maladie neurodégénérative complexe caractérisée par une perte progressive de la mémoire et de la cognition. C’est la première cause de démence chez le sujet âgé et affecte environs 4.6 millions de personnes par an, selon un rapport de l’association « Alzheimer’s disease International », le nombre de patients pourrait s’élever à 135.5 millions en 2050. Du fait de sa complexité, la MA reste incurable et seuls 4 médicaments aux vertus palliatives dont 3 visant à inhiber l’acétylcholinestérase (AChE) ont reçu une autorisation de mise sur le marché à ce jour. L’a

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29

Grimsley, Philip George Medical Sciences Faculty of Medicine UNSW. "Receptor mediated catabolism of plasminogen activators." Awarded By:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/44489.

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Humans have two plasminogen activators (PAs), tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which generate plasmin to breakdown fibrin and other barriers to cell migration. Both PAs are used as pharmaceuticals but their efficacies are limited by their rapid clearance from the circulation, predominantly by parenchymal cells of the liver. At the commencement of the work presented here, the hepatic receptors responsible for mediating the catabolism of the PAs were little understood. tPA degradation by hepatic cell lines was known to depend on the forma

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30

Eberhardt, Jérôme. "Etude de la dynamique structurale du domaine de liaison au ligand de RXRα et implication de la phosphorylation dans la transcription". Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ118/document.

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De nombreuses études révèlent que le domaine de liaison au ligand de RXRα est très dynamique, même en présence d'un ligand agoniste. Nous avons utilisé les données expérimentales (HDX, RMN et X-ray) disponibles sur ce domaine pour mettre en place un protocole, basé sur la dynamique moléculaire accélérée, permettant d'explorer efficacement la dynamique conformationnelle du domaine de liaison au ligand de RXRα et de valider les ensembles conformationnels obtenus. Ce protocole a été appliqué pour analyser l'influence de la phosphorylation pSer260, située à proximité de la surface d'interaction av

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31

Belorusova, Anna. "Structure-function studies of the vitamin D nuclear receptor complex with the coactivator MED1." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ039.

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Le récepteur de la vitamine D (VDR) est un facteur de transcription activé par la forme active de la vitamine D3. VDR est une cible thérapeutique potentielle pour de multiples pathologies telles que les maladies auto-immunes et neurodégénératives et certains cancers. VDR module l’expression de gènes par le recrutement sélectif de corégulateurs. Les données structurales disponibles à ce jour pour des complexes de récepteur nucléaire-corégulateurs sont très limitées. Cette étude se focalise sur l’architecture du complexe formé par VDR et un grand fragment du coactivateur MED1, une sous-unité du

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32

Ferrario, Maria Giovanna. "On the recognition of ecdysteroids by the ecdysone receptor : a computational study." Strasbourg, 2010. https://publication-theses.unistra.fr/restreint/theses_doctorat/2010/FERRARIO_Maria_Giovanna_2010.pdf.

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33

Amal, Ismail. "Étude in silico de la régulation allostérique du récepteur à l’acide rétinoïque par phosphorylation." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ029.

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Анотація:

L'acide rétinoïque (AR) joue un rôle important dans plusieurs processus cellulaires à travers la régulation de la différentiation cellulaire, de la prolifération et de l'apoptose. Ces propriétés sont à la base de l'utilisation de l'AR dans le traitement de plusieurs cancers dont la leucémie aiguë promyélocytaire. Décrypter comment l'AR contrôle l'expression de gènes spécifiques est un défi permanent pour l'étude des cancers. Les effets de l'AR sont médiés in vivo principalement par les récepteurs à l'acide rétinoïque (RARs). Il a été récemment démontré que la phosphorylation des RARs par diffé

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34

Asencio, Hernandez Julia. "Novel approaches in NMR and biophysics for the study of complex systems : application to the N-terminal domain of the androgen receptor." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ013/document.

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Cette thèse vise à réaliser une étude approfondie sur le développement de méthodologies pour l’analyse de systèmes complexes. Cela comprend l’étude des systèmes hors d’équilibre, des systèmes d’auto-assemblage, et les systèmes biologiques désordonnés. Les méthodes développées recouvrent principalement la RMN, tel que la mesure de diffusion (DOSY) mais également d’autres techniques telles que la spectrométrie de masse, le dichroïsme circulaire (CD), la microscopie électronique (EM) et diffusion des rayons X aux petits angles (SAXS). La partie N-terminale du récepteur des androgènes (AR) est uti

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35

Casiraghi, Marina. "Functional modulation of a G protein-coupled receptor conformational landscape in a lipid bilayer." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC138/document.

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Анотація:

Les récepteurs couplés aux protéines G (GPCRs en anglais) représentent la famille de récepteurs intégrales de membrane plus vaste dans la majorité des cellules eucaryotes. Ils jouent un rôle clé dans la transduction de signal, ainsi que la compréhension de leur mécanisme de signalisation représente une des questions principales dans la biologie d'aujourd'hui. Dans la caractérisation du paysage énergétique de ces récepteurs à l'échelle atomique, les structures cristallographiques publiées pendant la décennie dernière par cristallographie aux rayons X représentent la percée scientifique majeure

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36

Smith, Mark Edward 1975. "Molecular wires : syntheses, electrochemistry and properties of metal complexes containing carbon chains / by Mark Edward Smith." Thesis, 2002. http://hdl.handle.net/2440/21831.

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"September 2002"<br>Includes as appendix: a list of publications by the author arising from this work; and, copies of some published journal articles<br>Includes bibliographical references.<br>[12], 209 leaves, [35] pages : ill. ; 30 cm.<br>Describes the synthesis, properties and reactions of transition metal complexes containing poly-ynyl ligands<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2002

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37

Smith, Mark Edward 1975. "Molecular wires : syntheses, electrochemistry and properties of metal complexes containing carbon chains." 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phs654.pdf.

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Анотація:

"September 2002" Includes as appendix: a list of publications by the author arising from this work; and, copies of some published journal articles Includes bibliographical references. Describes the synthesis, properties and reactions of transition metal complexes containing poly-ynyl ligands

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38

Prevost, Monique. "A ligand binding analysis of the nicotinic acetylcholine receptors in the locust Locusta migratoria." 2001. http://wwwlib.umi.com/cr/yorku/fullcit?pMQ66399.

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Анотація:

Thesis (M. Sc.)--York University, 2001. Graduate Programme in Biology.<br>Typescript. Includes bibliographical references (leaves 106-118). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pMQ66399.

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39

Li, Guoyong. "Covalent modification regulates ligand binding to receptor complexes in the chemosensory system of Escherichia coli." 2000. https://scholarworks.umass.edu/dissertations/AAI9988815.

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How does a bacteria integrate a variety of signals received at its surface and respond with flagella rotation either in CCW or in CW? Several experimental approaches have been used to identify possible mechanism of transmembrane signaling. The different studies suggest different mechanisms of transmembrane signaling (Milburn et al., 1991; Lynch and Koshland, 1992; Chervitz and Falke, 1996; Maddock and Shapiro, 1993; Long and Weis, 1992; Liu et al., 1997; Li et al., 1997). However, most of the evidence including the one from this study either directly or indirectly points out that a receptor cl

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40

Hu, Tian-jing. "Regulation of process retraction and cell migration by Epha3 is mediated by the by the adaptor protein Nck1." 2007. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16096.

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Cooper, Margaret Ann. "Novel developmental roles of EphA receptors." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17454.

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42

Majumdar, Ritankar. "Activation Of Glycoprotein Hormone Receptors : Role Of Different Receptor Domains In Hormone Binding And Signaling." Thesis, 2012. https://etd.iisc.ac.in/handle/2005/2344.

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Анотація:

The glycoprotein hormones, Luteinizing Hormone (LH), human Chorionic Gonadotropin (hCG), Follicle Stimulating Hormone (FSH) and Thyroid Stimulating Hormone (TSH) are heterodimeric proteins with an identical α-subunit associated non-covalently with the hormone specific β-subunit and play important roles in reproduction and overall physiology of the organism [1]. The receptors of these hormones belong to the family of G-protein coupled receptors (GPCR) and have a large extracellular domain (ECD) comprising of 9-10 leucine rich repeats (LRR) followed by a flexible hinge region, a seven helical tr

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43

Majumdar, Ritankar. "Activation Of Glycoprotein Hormone Receptors : Role Of Different Receptor Domains In Hormone Binding And Signaling." Thesis, 2012. http://etd.iisc.ernet.in/handle/2005/2344.

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Анотація:

The glycoprotein hormones, Luteinizing Hormone (LH), human Chorionic Gonadotropin (hCG), Follicle Stimulating Hormone (FSH) and Thyroid Stimulating Hormone (TSH) are heterodimeric proteins with an identical α-subunit associated non-covalently with the hormone specific β-subunit and play important roles in reproduction and overall physiology of the organism [1]. The receptors of these hormones belong to the family of G-protein coupled receptors (GPCR) and have a large extracellular domain (ECD) comprising of 9-10 leucine rich repeats (LRR) followed by a flexible hinge region, a seven helical tr

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44

Shakibaei, M., C. Buhrmann, and A. Mobasheri. "Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells." 2011. http://hdl.handle.net/10454/6182.

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Resveratrol is a polyphenolic phytoestrogen that has been shown to exhibit potent anti-oxidant, anti-inflammatory, and anti-catabolic properties. Increased osteoclastic and decreased osteoblastic activities result in bone resorption and loss of bone mass. These changes have been implicated in pathological processes in rheumatoid arthritis and osteoporosis. Receptor activator of NF-kappaB ligand (RANKL), a member of the TNF superfamily, is a major mediator of bone loss. In this study, we investigated the effects of resveratrol on RANKL during bone morphogenesis in high density bone cultures in

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45

Katsiaouni, Stamatia. "Neuartige Pyrrol/Pyrazol-Bausteine für die Synthese von Hybrid-Makrozyklen, azyklischen Ligandsystemen und bimetallischen Komplexen." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-ACA0-A.

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