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Статті в журналах з теми "Retina Implant"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Koitschev, Assen, Katarina Stingl, Karl Ulrich Bartz-Schmidt, et al. "Extraocular Surgical Approach for Placement of Subretinal Implants in Blind Patients: Lessons from Cochlear-Implants." Journal of Ophthalmology 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/842518.

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Анотація:

In hereditary retinal diseases photoreceptors progressively degenerate, often causing blindness without therapy being available. Newly developed subretinal implants can substitute functions of photoreceptors. Retina implant extraocular surgical technique relies strongly on cochlear-implant know-how. However, a completely new surgical approach providing safe handling of the photosensor array had to be developed. The Retina Implant Alpha IMS consisting of a subretinal microphotodiode array and cable linked to a cochlear-implant-like ceramic housing was introduced via a retroauricular incision th

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2

Kusnyerik, Ákos, Miklós Resch, Tamás Roska, et al. "Vision restoration with implants in retinal degenerations." Orvosi Hetilap 152, no. 14 (2011): 537–45. http://dx.doi.org/10.1556/oh.2011.29064.

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Up until now there has been no available treatment for diseases causing the permanent impairment of retinal photoreceptors. Currently the development of the retinal prostheses is the earliest to promise a result that can be implemented in the clinical treatment of these patients. Implants with different operating principles and in various stages of progress are presented in details, highlighting the characteristics, as well as the Hungarian aspects of the development. This survey intends to provide an overview on retinal prostheses, implantable in case of degenerative diseases of the retina, b

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3

Greco, Jordan A., Nicole L. Wagner, Ralph J. Jensen, et al. "Activation of retinal ganglion cells using a biomimetic artificial retina." Journal of Neural Engineering 18, no. 6 (2021): 066027. http://dx.doi.org/10.1088/1741-2552/ac395c.

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Abstract Objective. Biomimetic protein-based artificial retinas offer a new paradigm for restoring vision for patients blinded by retinal degeneration. Artificial retinas, comprised of an ion-permeable membrane and alternating layers of bacteriorhodopsin (BR) and a polycation binder, are assembled using layer-by-layer electrostatic adsorption. Upon light absorption, the oriented BR layers generate a unidirectional proton gradient. The main objective of this investigation is to demonstrate the ability of the ion-mediated subretinal artificial retina to activate retinal ganglion cells (RGCs) of

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4

Shelke, D. A., and S. Shirolkar. "DRUG DELIVERY TO RETINA: A REVIEW." INDIAN DRUGS 56, no. 09 (2019): 7–21. http://dx.doi.org/10.53879/id.56.09.11991.

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The drug delivery to posterior segment especially to retina of eye is difficult due to various barriers. The diseases affecting the retina of eye are increasing and hence there is need to develop approaches for drug delivery to retina. This review describes the anatomy of retina, barriers associated with it, and diseases of retina. The drug delivery to retina by systemic, topical, intravitreal injection, intravitreal implant along with advance nanotechnology based and transporter mediated drug delivery is discussed here. The recent technologies in retinal drug delivery are also discussed to gi

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5

Ho, Elton, Richard Smith, Georges Goetz, et al. "Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation." Journal of Neurophysiology 119, no. 2 (2018): 389–400. http://dx.doi.org/10.1152/jn.00872.2016.

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Анотація:

Subretinal prostheses aim at restoring sight to patients blinded by photoreceptor degeneration using electrical activation of the surviving inner retinal neurons. Today, such implants deliver visual information with low-frequency stimulation, resulting in discontinuous visual percepts. We measured retinal responses to complex visual stimuli delivered at video rate via a photovoltaic subretinal implant and by visible light. Using a multielectrode array to record from retinal ganglion cells (RGCs) in the healthy and degenerated rat retina ex vivo, we estimated their spatiotemporal properties fro

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6

Elliott, Michael S., and Sandra R. Montezuma. "Retina Injury After Dexamethasone Injection Into a Vitrectomized Eye." Journal of VitreoRetinal Diseases 4, no. 6 (2020): 538–40. http://dx.doi.org/10.1177/2474126420934238.

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Purpose: This work reports a case of retinal and vitreous hemorrhage after a dexamethasone (Ozurdex, Allergan) intravitreal implant injection to treat clinically significant macular edema (ME) in a patient with moderate nonproliferative diabetic retinopathy. Methods: A 61-year-old woman who had a vitrectomy 3 years prior in the right eye underwent intravitreal dexamethasone implant injection in the right eye. Immediately after the injection, the patient noted numerous floaters, with visual acuity decline from 20/30 before injection, to counting fingers at 3 feet after injection. Dilated examin

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7

Greco, Jordan A., Luis André L. Fernandes, Nicole L. Wagner, et al. "Pixel Characterization of a Protein-Based Retinal Implant Using a Microfabricated Sensor Array." International Journal of High Speed Electronics and Systems 26, no. 03 (2017): 1740012. http://dx.doi.org/10.1142/s0129156417400122.

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Retinal degenerative diseases are characterized by the loss of photoreceptor cells within the retina and affect 30-50 million people worldwide. Despite the availability of treatments that slow the progression of degeneration, affected patients will go blind. Thus, there is a significant need for a prosthetic that is capable of restoring functional vision for these patients. The protein-based retinal implant offers a high-resolution option for replacing the function of diseased photoreceptor cells by interfacing with the underlying retinal tissue, stimulating the remaining neural network, and t

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8

Cai, Youran, Ye Yang, and Xin Zhong. "A Case Report of Intravitreal Dexamethasone Implant with Exudative Retinal Detachment for Ocular Toxocariasis Treatment." Korean Journal of Parasitology 60, no. 2 (2022): 133–37. http://dx.doi.org/10.3347/kjp.2022.60.2.133.

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Toxocariasis is one of the most common geohelminth infections in several parts of the world. We describe a rare case of ocular toxocariasis with secondary exudative retinal detachment treated with albendazole and an intravitreal dexamethasone implant. A 13-year-old boy with counting finger vision was diagnosed with retinal vasculitis and exudative retinal detachment in his right eye. Fundoscopic examination revealed retinal hemorrhage, retinal vasculitis, and exudative retinal detachment. Serological test using serum and intraocular aqueous humor were positive for anti-Toxocara specific IgG an

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9

Christensen, Logan, Riley Sanders, and Jeffrey Olson. "“Magic Bullet”: Eccentric Macular Hole as a Complication from Dexamethasone Implant Insertion." Case Reports in Ophthalmological Medicine 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/1706234.

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Анотація:

Introduction. Intravitreal drug injections and implants are generally safe but do carry some risk, from both the procedure itself and adverse effects of the medications. We report a case of an eccentric macular hole after dexamethasone implant (Ozurdex®) administration.Ex vitroforce testing was performed to evaluate dexamethasone implant injection force.Methods. Five dexamethasone implant (Ozurdex) applicators were placed 16 mm from a force plate and the force of the injected dexamethasone pellet was recorded in Newtons. Four dexamethasone implant applicators were placed 16 mm from a force pla

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10

Alavanthar, T., and V. Ellappan. "Stimulating electrode Design for Implantable Sub Retina Research Application: A Novel Approach." International Journal of Engineering & Technology 7, no. 2.24 (2018): 570. http://dx.doi.org/10.14419/ijet.v7i2.24.12509.

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This paper aims to study and converse the theoretical model of neural stimulation implant electrodes with the electrochemical aspects of design. The study investigates the practically realizable hypothetical model of minimal invasive retinal implant (miRI) stimulating electrodes for restoring lost sight of patients blinded by degenerative retinal diseases. The basic elemental methods of charge injection by the stimulation electrode to tissue are pointed out. A prologue on the developments of vision implants and electrode characteristics were presented. We communicated the most important factor

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11

Eger, Marcus, Marcus Wilms, Reinhard Eckhorn, Thomas Schanze, and Lutz Hesse. "Retino-cortical information transmission achievable with a retina implant." Biosystems 79, no. 1-3 (2005): 133–42. http://dx.doi.org/10.1016/j.biosystems.2004.09.030.

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12

Bikbov, Mukharram M., Rinat R. Fayzrakhmanov, Timur R. Gil’manshin, and Inga I. Arslangareeva. "Morphological changes in the macular area at post-thrombotic maculopathy after intravitreal injection of a dexamethasone implant (evidence from 5 clinical cases)." Ophthalmology journal 9, no. 4 (2016): 90–97. http://dx.doi.org/10.17816/ov9490-97.

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Purpose. To evaluate the effect of intravitreal implant with dexamethasone on the morphological changes of macular area in patients with central retinal vein occlusion.Materials and methods. Results of optical coherence tomography of the central retinal area of 5 patients (5 eyes) with newly diagnosed central retinal vein occlusion complicated by macular edema (ME) are presented. All the patients underwent single intravitreal injection of dexamethasone implant. Maximal follow-up period – 12 months.Results. In 1 month after dexamethasone implant injection, we observed a decrease of foveal retin

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13

Meyer, Jörg-Uwe. "Retina implant—a bioMEMS challenge." Sensors and Actuators A: Physical 97-98 (April 2002): 1–9. http://dx.doi.org/10.1016/s0924-4247(01)00807-x.

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14

Iannetta, Danilo, Marc D. de Smet, Nicola Valsecchi, Luigi Fontana, and Jay Chhablani. "Viscoelastics Enable Dissection of Anterior Closed Funnels in Proliferative Vitreoretinopathy: A Retrospective Case Series." Case Reports in Ophthalmology 15, no. 1 (2024): 401–5. http://dx.doi.org/10.1159/000535795.

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Introduction: The present study aimed to describe a case series of patients in which a cohesive ophthalmic viscous device (OVD) was used to viscodissect and posteriorly displace the retina in cases of total retinal detachment complicated by proliferative vitreoretinopathy, operated with minimally invasive pars plana vitrectomy. Case Presentations: Three patients with a mean age of 67 years were included in the present study. One eye was aphakic, while the others were pseudophakic. OVD injection was performed through the limbus in the aphakic eye and via pars plana in the pseudophakic eyes. In

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15

Shechter, Yahel, Roni Cohen, Michael Namestnikov, et al. "Sequential Fabrication of a Three-Layer Retina-like Structure." Gels 10, no. 5 (2024): 336. http://dx.doi.org/10.3390/gels10050336.

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Анотація:

Tissue engineering is considered a promising approach to treating advanced degenerative maculopathies such as nonexudative age-related macular degeneration (AMD), the leading cause of blindness worldwide. The retina consists of several hierarchical tissue layers, each of which is supported by a layer underneath. Each of these layers has a different morphology and requires distinct conditions for proper assembly. In fact, a prerequisite step for the assembly of each of these layers is the organization of the layer underneath. Advanced retinal degeneration includes degeneration of the other reti

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16

Lytvynchuk, Lyubomyr, Annabelle Ebbert, Hana Studenovska, et al. "Subretinal Implantation of Human Primary RPE Cells Cultured on Nanofibrous Membranes in Minipigs." Biomedicines 10, no. 3 (2022): 669. http://dx.doi.org/10.3390/biomedicines10030669.

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Purpose: The development of primary human retinal pigmented epithelium (hRPE) for clinical transplantation purposes on biodegradable scaffolds is indispensable. We hereby report the results of the subretinal implantation of hRPE cells on nanofibrous membranes in minipigs. Methods: The hRPEs were collected from human cadaver donor eyes and cultivated on ultrathin nanofibrous carriers prepared via the electrospinning of poly(L-lactide-co-DL-lactide) (PDLLA). “Libechov” minipigs (12–36 months old) were used in the study, supported by preoperative tacrolimus immunosuppressive therapy. The subretin

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17

Cehofski, Lasse Jørgensen, Anders Kruse, Mads Odgaard Mæng, et al. "Dexamethasone Intravitreal Implant Is Active at the Molecular Level Eight Weeks after Implantation in Experimental Central Retinal Vein Occlusion." Molecules 27, no. 17 (2022): 5687. http://dx.doi.org/10.3390/molecules27175687.

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Central retinal vein occlusion (CRVO) is a visually disabling condition resulting from a thrombus in the major outflow vessel of the eye. The inflammatory response in CRVO is effectively treated with a dexamethasone (DEX) intravitreal implant. Uncovering the proteome changes following DEX implant intervention in CRVO may identify key proteins that mediate the beneficial effects of DEX. In six Göttingen minipigs, CRVO was induced in both eyes with an argon laser using a well-established experimental model. The right eyes were treated with a DEX intravitreal implant (Ozurdex, Allergan), while th

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18

Ottonelli, Ilaria, Andrea Bighinati, Elisa Adani, et al. "Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles." Pharmaceutics 15, no. 1 (2022): 25. http://dx.doi.org/10.3390/pharmaceutics15010025.

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A drawback in the development of treatments that can reach the retina is the presence of barriers in the eye that restrain compounds from reaching the target. Intravitreal injections hold promise for retinal delivery, but the natural defenses in the vitreous can rapidly degrade or eliminate therapeutic molecules. Injectable hydrogel implants, which act as a reservoir, can allow for long-term drug delivery with a single injection into the eye, but still suffer due to the fast clearance of the released drugs when traversing the vitreous and random diffusion that leads to lower pharmaceutic effic

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19

Cirafici, Paola, Maria Musolino, Michela Saccheggiani, Carlo Enrico Traverso, and Massimo Nicolò. "Multimodal Imaging Findings and Treatment with Dexamethasone Implant in Three Cases of Idiopathic Macular Telangiectasia Type 1." Case Reports in Ophthalmology 12, no. 1 (2021): 92–97. http://dx.doi.org/10.1159/000509850.

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This is a report of 3 patients diagnosed with idiopathic macular telangiectasia type 1 (MacTel 1) at Medical Retina Center of the University of Eye Clinic of Genova and then prospectically followed for a mean time of 26 months between 2016 and 2019. It is the first report of patients affected by MacTel 1 treated with dexamethasone (DEX) implant as a first choice of treatment. Aim of our study is to better characterize the disease using a multimodal wide-field imaging and to determine efficacy of DEX implant on MacTel 1 in terms of central macular thickness (CMT) and best-corrected visual acuit

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20

Gacek, Marcin, Jerzy Wyslocki, Joanna Gondro, Franciszek Badura, and Slawomir Letkiewicz. "Structure and Selected Properties of Intraocular Implants (PMMA, Acrylic)." Materiale Plastice 56, no. 3 (2019): 621–24. http://dx.doi.org/10.37358/mp.19.3.5241.

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This paper presents the results of an investigation into the structure and properties of intraocular lenses (IOL) that are available on the ophthalmological market. The majority of implants of this type are based on acrylics or poly(methyl methacrylate) (PMMA). The acrylic lenses can be curled, which allows the making of just a minor incision during the associated implant surgery. The drawback of PMMA implants is their high rigidity, resulting in the need for a larger incision during the implant surgery. The benefits accrued from wearing such an implant are (1) the correction of focus for clea

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21

Velten, Thomas, Thorsten Knoll, Frank Stracke, et al. "Wireless retina implant with large visual field." Current Directions in Biomedical Engineering 5, no. 1 (2019): 53–56. http://dx.doi.org/10.1515/cdbme-2019-0014.

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AbstractWe present the concept of a novel epiretinal prosthesis, consisting of a foil-based, miniaturized electronics with wireless optical energy and signal transmission and integrated electrostimulation. The aim is achieving a wideangle projection to create a large visual field. The implant having a diameter of 14 mm consists of a mosaic-like array of thinned silicon-based photodiodes combined with a polyimide foil. This thin implant, realized on a flexible foil for the first time, adapts to the curvature of the eye. Thin-film stimulation electrodes on the foil are electrically connected to

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22

Alteheld, N., G. Roessler, M. Vobig, and P. Walter. "The Retina Implant New Approach to a Visual Prosthesis / Das Retina-Implant Ein neuer Ansatz für eine Sehprothese." Biomedizinische Technik/Biomedical Engineering 49, no. 4 (2004): 99–103. http://dx.doi.org/10.1515/bmt.2004.020.

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23

Lee, Chae-Eun, Younginha Jung, and Yoon-Kyu Song. "8-Channel Biphasic Current Stimulator Optimized for Retinal Prostheses." Journal of Nanoscience and Nanotechnology 21, no. 8 (2021): 4298–302. http://dx.doi.org/10.1166/jnn.2021.19405.

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Анотація:

Retinal prostheses substitute the functionality of damaged photoreceptors by electrically stimulating retinal ganglion cells (RGCs). RGCs, densely packed in a small region, needs a high spatial resolution of the microelectrode, which in turn raises its impedance. Therefore, the high output impedance circuit and the high compliance output voltage are the key characteristics of the current-source-based stimulator. Also, as the system is intended to implant in the retina, the stimulation parameter should be optimized for efficiency and safety. Here we designed 8-channel neural stimulator customiz

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24

Kuehlewein, Laura, Veronique Kitiratschky, Mariya Gosheva, et al. "Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS." Ophthalmic Surgery, Lasers and Imaging Retina 48, no. 12 (2017): 993–99. http://dx.doi.org/10.3928/23258160-20171130-06.

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25

Zalewski, Dominik, Dorota Raczyńska, and Krystyna Raczyńska. "Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant." Mediators of Inflammation 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/364143.

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Aims. This retrospective analysis was aimed at evaluating the effectiveness of treatment of persistent diabetic macular edema with intravitreal injections of 0.7 mg dexamethasone implant Ozurdex. The study comprised three male patients (6 eyes).Results. The average thickness of the retina at baseline was 632 μm, the medial BCVA was 0.8 logMAR, and corrected intraocular pressure was 13.7 mmHg. The maximum decrease in mean retinal thickness was observed at four weeks following the treatment and was 365 μm (−267 μm) and visual acuity improved by an average of two lines and was 0.6 logMAR. The lar

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26

Spinetta, Roberta, Francesco Petrillo, Michele Reibaldi, et al. "Intravitreal DEX Implant for the Treatment of Diabetic Macular Edema: A Review of National Consensus." Pharmaceutics 15, no. 10 (2023): 2461. http://dx.doi.org/10.3390/pharmaceutics15102461.

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Diabetic macular edema (DME)’s therapeutic approach can frequently be challenging. The purpose of the review is to propose evidence-based recommendations on the employment of intravitreal dexamethasone implants (DEX) when approaching patients suffering from DME. Seven national consensuses redacted by different groups of retina specialists from Europe and Asia were examined and confronted. Each consensus was redacted utilizing a Delphi approach, in person meetings, or by reviewing the literature. DEX can be studied as a first-line strategy in individuals suffering from DME with inflammatory OCT

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27

Unzalu Lerma, Ekhiñe, and Eduardo Pérez-Salvador García. "Complication of device insertion of dexamethasone intravitreal implant." Oftalmología Clínica y Experimental 16, no. 04 (2023): e428-e433. http://dx.doi.org/10.70313/2718.7446.v16.n04.269.

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Purpose: To report a non-pharmacological complication occurred with the applicator of the dexamethasone intravitreal implant. Case report: Report a case of a 76-year-old pseudophakic women treated with dexamethasone intravitreal implant (Ozurdex™, Abbvie) because of cystoid macular edema in the left eye. During the procedure a malfunction related to the mandrel during the injection procedure occurred. The mandrel of the device came out of the pen, becoming embedded in the sclera. As soon as the bar was visualized in the sclera, it was removed with the help of Adson forceps. No complications oc

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28

Esmaili, Daniel D., and David S. Boyer. "Recent advances in understanding and managing retinal vein occlusions." F1000Research 7 (April 16, 2018): 467. http://dx.doi.org/10.12688/f1000research.12886.1.

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Retinal vein occlusions are the second most common form of retinal vascular disease. Previously, laser treatment for branch retinal vein occlusion and intravitreal triamcinolone acetonide for central retinal vein occlusion were the standard of care. Recent studies have demonstrated that anti-vascular endothelial growth factor (anti-VEGF) agents have a superior safety and efficacy profile for the treatment of both branch and central retinal vein occlusions. The use of wide-field fluorescein angiography has also allowed better visualization of the retinal periphery. Despite the better documentat

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29

Gerding, H. "A new approach towards a minimal invasive retina implant." Journal of Neural Engineering 4, no. 1 (2007): S30—S37. http://dx.doi.org/10.1088/1741-2560/4/1/s05.

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30

Bikbov, M. M., T. R. Gilmashin, and K. I. Kudoyarova. "Criteria for resistance in diabetic macular edema." POINT OF VIEW. EAST – WEST, no. 3 (October 27, 2023): 11–16. http://dx.doi.org/10.25276/2410-1257-2023-3-11-16.

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Purpose. To evaluate the morphofunctional features of diabetic macular edema (DME) and propose a classification of the degree of its resistance. Material and methods. The study included 448 patients (448 eyes) with newly diagnosed DME. A complete ophthalmological examination was performed, including spectral optical coherence tomography of the macular area. All patients were divided into 3 study groups depending on the anti-VEGF drug used: Brolucizumab (138), Ranibizumab (142) and Aflibercept (168). All patients (110) resistant to loading doses of an anti-VEGF drug were switched to intravitrea

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31

KÜÇÜK, Numan, and Atilla ALPAY. "Diyabetik Makula Ödemli Hastalarda Deksametazon İmplantının Retina Sinir Lifi Tabakası ve Optik Sinir Çukurluk/Disk Oranı Üzerine Etkisi." Turkish Journal of Diabetes and Obesity 6, no. 2 (2022): 143–48. http://dx.doi.org/10.25048/tudod.1142334.

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Amaç: Bu çalışmanın amacı diyabetik maküla ödemi bulunan hastalarda tek doz intravitreal Deksametazon (DEX) implantının peripapiller retina sinir lifi tabakası (RNFL) kalınlığına ve optik sinir çukurluk/disk (C/D) oranına etkisini araştırmaktır. Gereç ve Yöntemler: İntravitreal DEX implant enjeksiyonu öncesi peripapiller RNFL kalınlık ölçümleri ve renkli fundus fotoğrafları enjeksiyondan 6 ay sonrası ile karşılaştırıldı. Fundus fotoğraflarının C/D oranları Image-J programı kullanılarak hesaplandı. Bulgular: Kırk üç hastanın 58 gözüne intravitreal DEX implant enjeksiyonu

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32

ŞENGÜL, Elvan Alper, Özgür ARTUNAY, Esra TÜRKSEVEN KUMRAL, et al. "Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Central Retinal Vein Occlusion: Six Months Results." Turkiye Klinikleri Journal of Ophthalmology 25, no. 1 (2016): 30–35. http://dx.doi.org/10.5336/ophthal.2015-46854.

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33

Schwarz, M., R. Hauschild, B. J. Hosticka, et al. "Single-chip CMOS image sensors for a retina implant system." IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing 46, no. 7 (1999): 870–77. http://dx.doi.org/10.1109/82.775382.

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34

Grover, N., O. J. H. Whiteside, and J. D. Ramsden. "Susac syndrome: outcome of unilateral cochlear implantation." Journal of Laryngology & Otology 125, no. 8 (2011): 856–58. http://dx.doi.org/10.1017/s0022215111000600.

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AbstractObjective:Susac syndrome comprises a triad of vestibulocochlear dysfunction, retinopathy and multifocal encephalopathy, which is characterised pathophysiologically by microangiopathy of the ear, retina and brain. Diagnosis is confirmed by magnetic resonance imaging of the brain and ophthalmological examination, which reveals branch retinal artery occlusion. Hearing loss persists in 90 per cent of patients. We present a case of successful hearing rehabilitation by cochlear implantation in a young woman with this syndrome.Clinical presentation:A 36-year-old woman presented with neurologi

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Kompa, S., S. Langefeld, B. Kirchhof, K. Brenman, and N. Schrage. "Aachen-Keratoprosthesis as Temporary Implant. Case Report on First Clinical Application." International Journal of Artificial Organs 23, no. 5 (2000): 345–48. http://dx.doi.org/10.1177/039139880002300510.

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Background The Aachen-Keratoprosthesis was designed to serve as a permanent keratoprosthesis, modeling natural corneal physical properties as closely as possible. Prior to permanent application in patients, keratoprostheses are commonly tested in animal models to assess biochemical and biomechanical compatibility. However, immune and inflammatory responses acquired through animal experimentation are difficult to extrapolate in order to develop a predictable and generalized outcome in humans. Therefore, this preliminary report includes results following a temporary implantation of the Aachen-Ke

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Abu Samra, Khawla, Sandra Fernando Sieminski, and Vimal Sarup. "Decompression Retinopathy after ExPRESS Shunt Implantation for Steroid-Induced Ocular Hypertension: A Case Report." Case Reports in Ophthalmological Medicine 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/303287.

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Purpose. To present a unique case of decompression retinopathy after the implantation of ExPRESS drainage device.Method. A 25-year-old female patient underwent implantation of ExPRESS drainage device in the left eye for the management of steroid-induced ocular hypertension.Results. On the postoperative day one, best-corrected visual acuity in the left eye was 20/50. Fundus examination revealed diffuse intraretinal hemorrhages, some white-centered, throughout the retina. There was also marked tortuosity to the retinal vasculature and no evidence of choroidal effusion. Intravenous fluorescein an

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Hungar, Kaspar, Michael Görtz, Evelina Slavcheva, Gerd Spanier, Christopher Weidig, and Wilfried Mokwa. "Production processes for a flexible retina implant (Eurosensors XVIII, Session C6.6)." Sensors and Actuators A: Physical 123-124 (September 2005): 172–78. http://dx.doi.org/10.1016/j.sna.2005.03.061.

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Sekirnjak, C., P. Hottowy, A. Sher, W. Dabrowski, A. M. Litke, and E. J. Chichilnisky. "High-Resolution Electrical Stimulation of Primate Retina for Epiretinal Implant Design." Journal of Neuroscience 28, no. 17 (2008): 4446–56. http://dx.doi.org/10.1523/jneurosci.5138-07.2008.

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Kitiratschky, Veronique B. D., Katarina Stingl, Barbara Wilhelm, et al. "Safety evaluation of “retina implant alpha IMS”—a prospective clinical trial." Graefe's Archive for Clinical and Experimental Ophthalmology 253, no. 3 (2014): 381–87. http://dx.doi.org/10.1007/s00417-014-2797-x.

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Zrenner, Eberhart, Karl Ulrich Bartz-Schmidt, Heval Benav, et al. "Subretinal electronic chips allow blind patients to read letters and combine them to words." Proceedings of the Royal Society B: Biological Sciences 278, no. 1711 (2010): 1489–97. http://dx.doi.org/10.1098/rspb.2010.1747.

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A light-sensitive, externally powered microchip was surgically implanted subretinally near the macular region of volunteers blind from hereditary retinal dystrophy. The implant contains an array of 1500 active microphotodiodes (‘chip’), each with its own amplifier and local stimulation electrode. At the implant's tip, another array of 16 wire-connected electrodes allows light-independent direct stimulation and testing of the neuron–electrode interface. Visual scenes are projected naturally through the eye's lens onto the chip under the transparent retina. The chip generates a corresponding pat

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Pavlov, V. A., E. V. Kryukov, D. V. Davydov, A. A. Zaytsev, V. E. Kurnosov, and A. A. Kapatsina. "Experience with the use of glucocorticosteroid implants in patients with macular edema associated with sarcoidosis." Fyodorov journal of ophthalmic surgery, no. 3 (October 17, 2022): 28–33. http://dx.doi.org/10.25276/0235-4160-2022-3-28-33.

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Purpose. To evaluate the results of treatment of patients with sarcoidosis with chronic non-infectious uveitis complicated by macular edema by intravitreal injection of a glucocorticosteroid implant with previously used methods. Material and methods. The study performed a comparative analysis of data from patients with cystic macular edema against the background of chronic non-infectious uveitis associated with sarcoidosis, with corrected visual acuity of more than 0.05 (according to the Golovin-Sivtsev table). Group 1 (prospective analysis) included the results of treatment of patients with s

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Adelman, Ron A., Aaron J. Parnes, Silvia Bopp, Ihab Saad Othman, and Didier Ducournau. "Strategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/870987.

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Objective. To compare the efficacy of different therapies in the treatment of macular edema associated with retinal vein occlusion (RVO).Design. This is a nonrandomized, multicenter collaborative study.Participants. 86 retina specialists from 29 countries provided clinical information, including choice of treatment and outcome, on 2,603 patients with macular edema including 738 cases of RVO.Methods. Reported data included the type and number of treatments performed, visual acuities, and other clinical and diagnostic findings.Main Outcome Measures. The mean increase in visual acuity and mean nu

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Schwarz, M., L. Ewe, R. Hauschild, et al. "Single chip CMOS imagers and flexible microelectronic stimulators for a retina implant system." Sensors and Actuators A: Physical 83, no. 1-3 (2000): 40–46. http://dx.doi.org/10.1016/s0924-4247(00)00290-9.

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Christiansen, A. T., J. F. Kiilgaard, M. Smith, et al. "The Influence of Brightness on Functional Assessment by mfERG: A Study on Scaffolds Used in Retinal Cell Transplantation in Pigs." Stem Cells International 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/263264.

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To determine the effect of membrane brightness on multifocal electroretinograms (mfERGs), we implanted poly lactic-co-glycolic acid (PLGA) membranes in the subretinal space of 11 porcine eyes. We compared membranes with their native shiny white color with membranes that were stained with a blue dye (Brilliant Blue). Histological and electrophysiological evaluation of the overlying retina was carried out 6 weeks after implantation. Histologically, both white and blue membranes degraded in a spongiform manner leaving a disrupted outer retina with no preserved photoreceptor segments. Multifocal E

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Narayanan Nadig, Malini. "Development of a silicon retinal implant: cortical evoked potentials following focal stimulation of the rabbit retina with light and electricity." Clinical Neurophysiology 110, no. 9 (1999): 1545–53. http://dx.doi.org/10.1016/s1388-2457(99)00027-9.

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Mehmedovic, Azra, Vernesa Drino, Alma Biscevic, and Melisa Pjano. "Intravitreal Sustained-release Dexamethasone Implant in Treatment for Chronic Macular Edema in Syphilis Infection: a Case Report." Medical Archives 77, no. 5 (2023): 405. http://dx.doi.org/10.5455/medarh.2023.77.405-408.

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Background: Macular edema results from many conditions, such as diabetic retinopathy, macular degeneration, inflammatory diseases, cataract operation, trauma, and tumors. Specifically, the capillary filtration rate should equal the speed of fluid removal from extracellular retinal tissue, such as the glial and retinal pigment epithelium cells layer (RPE). Once these forces are imbalanced, fluid accumulates in cystoid spaces within the inner layers of the retina. Objective: The main purpose of this case report is to show that macular edema caused by any inflammation, either bacteria, virus, or

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Schanze, Thomas, Nina Greve, and Lutz Hesse. "Towards the cortical representation of form and motion stimuli generated by a retina implant." Graefe's Archive for Clinical and Experimental Ophthalmology 241, no. 8 (2003): 685–93. http://dx.doi.org/10.1007/s00417-003-0746-1.

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Stutzki, Henrike, Florian Helmhold, Max Eickenscheidt, and Günther Zeck. "Subretinal electrical stimulation reveals intact network activity in the blind mouse retina." Journal of Neurophysiology 116, no. 4 (2016): 1684–93. http://dx.doi.org/10.1152/jn.01095.2015.

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Retinal degeneration ( rd) leads to progressive photoreceptor cell death, resulting in vision loss. Stimulation of the inner-retinal neurons by neuroprosthetic implants is one of the clinically approved vision-restoration strategies, providing basic visual percepts to blind patients. However, little is understood as to what degree the degenerating retinal circuitry and the resulting aberrant hyperactivity may prevent the stimulation of physiological electrical activity. Therefore, we electrically stimulated ex vivo retinas from wild-type ( wt; C57BL/6J) and blind ( rd10 and rd1) mice using an

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Weitz, Andrew C., Matthew R. Behrend, Nan Sook Lee, et al. "Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators." Journal of Neurophysiology 109, no. 7 (2013): 1979–88. http://dx.doi.org/10.1152/jn.00852.2012.

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Epiretinal implants for the blind are designed to stimulate surviving retinal neurons, thus bypassing the diseased photoreceptor layer. Single-unit or multielectrode recordings from isolated animal retina are commonly used to inform the design of these implants. However, such electrical recordings provide limited information about the spatial patterns of retinal activation. Calcium imaging overcomes this limitation, as imaging enables high spatial resolution mapping of retinal ganglion cell (RGC) activity as well as simultaneous recording from hundreds of RGCs. Prior experiments in amphibian r

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Parmeggiani, Francesco, Katia De Nadai, Angela Piovan, Andrea Binotto, Sara Zamengo, and Marzio Chizzolini. "Optical Coherence Tomography Imaging in the Management of the Argus II Retinal Prosthesis System." European Journal of Ophthalmology 27, no. 1 (2017): 16–21. http://dx.doi.org/10.5301/ejo.5000852.

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Purpose To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. Methods This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol. Complete screening procedures had involv

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