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Добірка наукової літератури з теми "RHE"

Автор: Grafiati

Опубліковано: 10 січня 2023

Оновлено: 28 січня 2023

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Статті в журналах з теми "RHE"

Senthilan, Pingkalai R., and Charlotte Helfrich-Förster. "Rhodopsin 7–The unusual Rhodopsin inDrosophila." PeerJ 4 (September 6, 2016): e2427. http://dx.doi.org/10.7717/peerj.2427.

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Rhodopsins are the major photopigments in the fruit flyDrosophila melanogaster. Drosophilaexpress six well-characterized Rhodopsins (Rh1–Rh6) with distinct absorption maxima and expression pattern. In 2000, when theDrosophilagenome was published, a novelRhodopsingene was discovered:Rhodopsin 7(Rh7).Rh7is highly conserved among theDrosophilagenus and is also found in other arthropods. Phylogenetic trees based on protein sequences suggest that the sevenDrosophilaRhodopsins cluster in three different groups. While Rh1, Rh2 and Rh6 form a “vertebrate-melanopsin-type”–cluster, and Rh3, Rh4 and Rh5 form an “insect-type”-Rhodopsin cluster, Rh7 seem to form its own cluster. Although Rh7 has nearly all important features of a functional Rhodopsin, it differs from other Rhodopsins in its genomic and structural properties, suggesting it might have an overall different role than other known Rhodopsins.

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Hromadnikova, Ilona, Lenka Vechetova, Klara Vesela, Blanka Benesova, Jindrich Doucha, and Radovan Vlk. "Non-invasive Fetal RHD and RHCE Genotyping Using Real-time PCR Testing of Maternal Plasma in RhD-negative Pregnancies." Journal of Histochemistry & Cytochemistry 53, no. 3 (March 2005): 301–5. http://dx.doi.org/10.1369/jhc.4a6372.2005.

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We assessed the feasibility of fetal RHD and RHCE genotyping by analysis of DNA extracted from plasma samples of RhD-negative pregnant women using real-time PCR and primers and probes targeted toward RHD and RHCE genes. We analyzed 45 pregnant women in the 11th to 40th weeks of pregnancy and correlated the results with serological analysis of cord blood after delivery. Non-invasive prenatal fetal RHD exon 7, RHD exon 10, RHCE exon 2 (C allele), and RHCE exon 5 (E allele) genotyping analysis of maternal plasma samples was correctly performed in 45 out of 45 RhD-negative pregnant women delivering 24 RhD-, 17 RhC-, and 7 RhE-positive newborns. Detection of fetal RHD and the C and E alleles of RHCE gene from maternal plasma is highly accurate and enables implementation into clinical routine. We recommend performing fetal RHD and RHCE genotyping together with fetal sex determination in alloimmunized D-negative pregnancies at risk of hemolytic disease of the newborn. In case of D-negative fetus, amplification of another paternally inherited allele (SRY and/or RhC and/or RhE positivity) proves the presence of fetal DNA in maternal circulation.

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Fasano, Ross, Alessandro Monaco, Emily Riehm Meier, John Otridge, Hallie Lee-Stroka, Philippe Pary, Harvey G. Klein, Francesco M. Marincola, Naomi L. C. Luban, and David Stroncek. "The Emerging Role of RH Genotyping in Chronically Transfused Sickle Cell Disease Patients." Blood 112, no. 11 (November 16, 2008): 3035. http://dx.doi.org/10.1182/blood.v112.11.3035.3035.

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Abstract Background: Individuals of African descent have different molecular RH variants but their clinical significance with respect to alloantibody formation to high-incidence RH antigens has not been studied in multiply transfused patients. Some rare Rh phenotypes occur exclusively in the black population, yet their association with alloimmunization remains unclear. Current serological methods are unable to detect these variants; however, recent advances in molecular genotyping permit the identification of polymorphisms which may contribute to alloimmunization. Case: A 7-year-old Nigerian male with sickle cell disease (SCD) and with a silent stroke on routine MRI screening, was enrolled on the NHLBI Silent Infarct Transfusion Therapy (SITT) study and randomized to receive chronic transfusions. His RBC serological phenotype was: B, RhD-C+c+E-e+, K-. After receiving his ninth leukoreduced, Type B, D-, E-, K- RBC transfusion, he was found to have an alloantibody with “e-like” specificity. Serological evaluation revealed positive reactions of patient’s sera with all commercially available Rhe+ RBCs, positive reactions with Rhe+(hrs-) and Rhe+(hrB-) in some but not all enhancement media, and no reaction to a South African-specific Rhe+(hrs-) RBC sample in all enhancement media. RBC molecular phenotyping through two sequence specific primer polymerase chain reaction (SSP-PCR) methodology platforms revealed a blood type B, RHD-C-c+E-e+, K-; in addition, the cdes genotype (r’s) was detected on one of the two platforms. RH DNA sequencing revealed the presence of known heterozygous single nucleotide polymorphisms (SNPs) on RHCE exons 1, 5, and 7 for W16C, L245V, and G336C respectively. With the use of D-specific primers, a homozygous SNP was identified on RHD exon 8 (T379M) which designates RHCE exon 8 from RHD; however, RHD exons 2, 4–7 failed to amplify. With the use of non-specific RH primers, exons 2, 4, and 7 were amplified and sequenced, revealing CE-specific exons 4, and 7 sequences with the G336C substitution. With non-specific amplification of exon 2, sequences from both RHD and RHCE, in addition to the L62F polymorphism, were identified, indicating the presence of both RHD and RHCE sequences. Sequencing data from RHD exon 3 identified a D/CE fusion point witihin exon 3, with a nucleotide substitution at position 410C>T (A137V). Microarray results were consistent with the serologic phenotype and sequencing results, verified the presence of the cdes genotype, and confirmed the D/CE fusion point at exon 3. No signal was detected for RHD exons 2, and 4–7 indicating the large RHD deletion and RHCE insertion within the RHD gene. Conclusions: This RH genotype is consistent with the previously reported (C)ces genotype. SCD patients should be comprehensively screened for RH variants prior to initiating transfusion therapy in order to determine alloimmunization risk. RBC genotyping provides additional resolution to serologic investigations for the identification of unique RH polymorphisms, which can aid in appropriate selection of RBCs to avoid alloimmunization, or purely identifying individuals who may benefit from alternative methods of treatment for their disease, such as hydroxyurea or stem cell transplant in SCD patients.

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Cherif-Zahar, B., V. Raynal, AM D'Ambrosio, JP Cartron, and Y. Colin. "Molecular analysis of the structure and expression of the RH locus in individuals with D--, Dc-, and DCw- gene complexes." Blood 84, no. 12 (December 15, 1994): 4354–60. http://dx.doi.org/10.1182/blood.v84.12.4354.bloodjournal84124354.

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Анотація:

Rh blood group antigens of the D, C/c, and E/e series are carried by at least three red cell membrane polypeptides encoded by two highly related genes, RHD and RHCE. Homozygous individuals carrying the D--, Dc-, and DCw- gene complexes are characterized by a total or partial lack of expression of the RHCE-encoded antigens. Analysis of the molecular genetic basis of these rare conditions indicates that complete or partial expression defect of Cc/Ee antigens result from different alterations at the RH locus, but not from gross deletions. No rearrangement or mutation of the RHCE gene could be detected in donors homozygous for the D-- complex, suggesting that the lack of the Cc and Ee antigens might result from a reduced transcriptional activity of the RHCE gene. The Dc- and DCw- gene complexes, however, exhibited an important rearrangement of the RHCE gene. Instead of the normal RHCE gene, both variants carried a hybrid RHCE-D-CE gene in which exons 4 to 9 (Dc- complex) and 2 (or 3) to 9 (DCw- complex) of the RHCE gene, respectively, have been substituted by the equivalent region of the RHD gene. These gene conversion events provide an explanation for the well- described abnormal antigen profiles associated with the Dc- and DCw- complexes, like the increased expression of RhD, the reduced expression of RhC/c or RhCw, and the absence of RhE/e.

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Costa, Sidneia Sanches, A. K. Chiba, F. O. Martin, Dante M. Langhi, C. S. Chiattone, and Jose Orlando Bordin. "ANTI-hrs associated with the RHD-RHCE HAPLOTYPE DAR-ceAR in a patient with Sickle Cell Trait." Blood 112, no. 11 (November 16, 2008): 4066. http://dx.doi.org/10.1182/blood.v112.11.4066.4066.

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Abstract Introduction: The RH blood group system is the most polymorphic and immunogenic among blood groups and some rare Rh phenotypes are found exclusively in the black population. The RH 18 phenotype (Hr-negative) that is one of these phenotypes is characterized by a high incidence antigen. The production of anti-RH 18 imposes to use equivalent rare antigen-negative red blood cells (RBCs), or deleted-Rh RBCs (Rhnull or D- -) for transfusion. Case Report: A 24-year-old female patient with two previous abortions and one ectopic pregnancy and miscarriage had to be transfused with a RBC unit. She was typed as blood group A, Dccee phenotype with weak D, positive RBC antibody screening, auto-control negative and TAD negative. The antibody was anti-e (title 1/64) determined by testing serum against a commercial RBC panel (Fresenius-Kabi) by IgG indirect antiglobulin test tube (PEG-IAT), and nontreated (LissCoombs) and papain-treated RBCs on a gel matrix (DiaMed, Latino America). After adsorption of serum on Rhe-negative RBC (DccEE), the retrieving antibody was an anti-e-like antibody reacting with all normal Rhe-positive RBCs. Molecular and serologic Rh typing was also performed on blood samples obtained from five relatives of the patient and her husband. Results: Patient and relatives cDNA sequence of gene RHD and RHCE transcripts were analyzed for RHCE exons 4 to 5 and exon 6; for RHD exons 4 to 5, 6 and 7. Sequencing of cDNA from the patient, her father and her sister showed in RHD the presence of the DAR allele point mutation 602 C>G in exon 4; 667 T>G and 744 C>T in exon 5; 957 G>A and 1025 T>C in exon 7; while on gene RHCE we found the ceAR allele carrying 712 A>G, 733 C>G e 787 A>G in exon 5. Hemoglobin tests revealed that the patient, her father and sister had a sickle cell trait (patient HbA1=55%; HbA2=2,8%; HbS=41%; HbF=1,2%; father HbA1=58,5%; HbA2=1,4%; HbS=37,7%; HbF=2,4%; sister HbA1=57,4%; HbA2=2,5%; HbS=38,6%; HbF=1,5%). Discussion: The family study showed that the haplotype DAR-ceAR was inherited from her father. Individuals carrying the ceAR allele may produce anti-hrs antibody that is defined as a Rhe-like which does not react with rare Rhe positive variant RBCs. The antibody may be clinically significant and represents a great risk for those patients who are not transfused with a similar rare phenotype variant. Serologically, DAR has shown weaker reactions with anti-D, it is characterized by complete loss of at least 9 of 37 RhD epitopes, and may produce anti-D. Both mutated alleles show a replacement of RHD exons by RHCE counterparts.

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Umenishi, F., E. Kajii, and S. Ikemoto. "A new genomic polymorphism of Rh-polypeptide genes." Biochemical Journal 299, no. 1 (April 1, 1994): 203–6. http://dx.doi.org/10.1042/bj2990203.

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To determine which Rh-polypeptide genes are related to which Rh (rhesus) antigens, genomic DNAs prepared from donors of ten kinds of different Rh phenotypes were analysed by Southern hybridization method using two probes for the 5′ moiety and 3′ moiety of an Rh-polypeptide cDNA. A polymorphism for the Rh blood-group system was observed with BamHI, HindIII, PstI and EcoRI restriction endonucleases between genomic DNAs from the RhD-positive and RhD-negative individuals as has previously been reported. Further study showed an additional genomic polymorphism. The new polymorphism was detected between the RhC/c phenotypes unrelated to the RhD/d phenotypes with RsaI restriction endonuclease using the probe for the 5′ moiety of Rh polypeptide cDNA. A 1.9 kb RasI restriction fragment was missing in the genomes from individuals with the RhC phenotypes. However, this fragment was present in the genomes of Rhc phenotypes and in its half dose in the genomes of RhCc phenotypes. These results clearly demonstrate a new polymorphism between the RhC/c phenotypes regardless of the RhD-positive and RhD-negative phenotypes, and it is predicted that the Rh polypeptide genes encoding RhD, RhC/c and RhE/e antigens are different.

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Sambo, Paolo, Franco Sannazzaro, and Michael R. Evans. "Physical Properties of Ground Fresh Rice Hulls and Sphagnum Peat Used for Greenhouse Root Substrates." HortTechnology 18, no. 3 (January 2008): 384–88. http://dx.doi.org/10.21273/horttech.18.3.384.

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Ground fresh rice (Oryza sativa) hull materials were produced by grinding whole fresh rice hulls and passing the resulting product through a 1-, 2-, 4- or 6-mm-diameter screen to produce a total of four ground rice products (RH1, RH2, RH4, and RH6, respectively). The physical properties and water release characteristics of sphagnum peatmoss (peat) and the four ground rice hull products were evaluated. All of the ground rice hull products had a higher bulk density (Bd) than peat, and as the grind size of the rice hull particle decreased, Bd increased. Peat had a higher total pore space (TPS) than all of the ground rice hull products except for RH6. As grind size decreased, the TPS decreased. Peat had a lower air-filled pore space (AFP) than all of the ground rice hull products and as the grind size of the rice hull products decreased, AFP decreased. Peat had a higher water holding capacity (WHC) than all of the ground rice hull products. Grind sizes RH4 and RH6 had similar WHC, whereas RH1 and RH2 had a higher WHC than RH4 and RH6. Peat, RH4, and RH6 had similar available water content (AVW), whereas RH2 had higher AVW than these materials and RH1 had the highest AVW. However, peat had the lowest AVW and easily available water (EAW) as a percentage of the WHC. The ground rice hull products RH1 and RH2 had the highest AVW and EAW of the components tested. Peat had the highest water content at container capacity. As pressure was increased from 1 to 5 kPa, peat released water more slowly than any of the ground rice hull products. The RH1 and RH2 ground hull products released water at a significantly higher rate than peat, but RH4 and RH6 released the most water over these pressures. For all rice hull products, most water was released between 1 and 2 kPa pressure. The rice hull products RH1 and RH2 had physical properties that were within recommended ranges and were most similar to those of peat.

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Kim, Caroline, Isabelle Mouro, Yves Brossard, Jacques Chavinie, Jean Pierre Cartron, and Yves Colin. "PCR-based determination of Rhc and RhE status of fetuses at risk of Rhc and RhE haemolytic disease." British Journal of Haematology 88, no. 1 (September 1994): 193–95. http://dx.doi.org/10.1111/j.1365-2141.1994.tb04996.x.

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Rouillac, C., P. Gane, J. Cartron, PY Le Pennec, JP Cartron, and Y. Colin. "Molecular basis of the altered antigenic expression of RhD in weak D(Du) and RhC/e in RN phenotypes." Blood 87, no. 11 (June 1, 1996): 4853–61. http://dx.doi.org/10.1182/blood.v87.11.4853.bloodjournal87114853.

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The RH blood group locus is composed of two sequence-related genes, RHD and RHCE, encoding the D, Cc, and Ee antigens in common Rh-positive phenotypes. In this report, we have analyzed the molecular basis of Rh antigens expression in weak D (Du) and RN donors, in whom there is a severe reduction of the D and C/e antigens, respectively. Genomic and transcript analysis of three unrelated low-grade weak D (Du) variants indicated that the very low expression of the D antigen is not the result of rearrangement or mutation in the coding sequence of the RHO gone. Accordingly, weak D (Du) erythrocytes should carry a normal RhD polypeptide, which is in agreement with the observation that these variants never produce anti-D antibodies. Comparative polymerase chain reaction analysis showed a lower steady-state level of RhD transcripts in weak D (Du) reticulocytes, as compared with normal RhD-positive controls, thus providing direct evidence that the difference between the D antigen of D-positive and weak D (Du) red blood cells is quantitative only. Conversely, analysis of the molecular genetic basis of the RN phenotype Indicated that the severely decreased expression of the RhC and Rhe antigens in three variants is associated with a qualitative alteration identified as a segmental DNA exchange between the RHCE and RHD genes. These genomic rearrangements, which resulted in hybrid RhCe-D-Ce proteins expressing the low frequency Rh32 but not the high incidence Rh46 antigens, involved either axon 4 alone or both exons 3 and 4. These findings show that an identical phenotypical alteration of Rh antigens (reduced expression) may result either from a quantitative or a qualitative alteration of the RH genes expression.

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Chou, W. H., A. Huber, J. Bentrop, S. Schulz, K. Schwab, L. V. Chadwell, R. Paulsen, and S. G. Britt. "Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification." Development 126, no. 4 (February 15, 1999): 607–16. http://dx.doi.org/10.1242/dev.126.4.607.

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Opsin gene expression in the R7 and R8 photoreceptor cells of the Drosophila compound eye is highly coordinated. We have found that the R8 cell specific Rh5 and Rh6 opsins are expressed in non-overlapping sets of R8 cells, in a precise pairwise fashion with Rh3 and Rh4 in the R7 cells of individual ommatidia. Removal of the R7 cells in sevenless, boss or sina mutants, disrupts Rh5 expression and dramatically increases the number of Rh6-expressing R8 cells. This suggests that the expression of Rh5 may be induced by an Rh3-expressing R7 cell, whereas Rh6 expression is most likely a default state of the R8 cell. We found that the paired expression of opsin genes in the R7 and R8 cells occurs in a sevenless and boss independent manner. Furthermore, we found that the generation of both Rh3- and Rh4-expressing R7 cells can occur in the absence of an R8 cell. These results suggest that the specification of opsin expression in the R7 cells may occur autonomously, whereas the R7 photoreceptor cell may be responsible for regulating a binary developmental switch between induced and default cell-fates in the R8 cell.

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Більше джерел

Дисертації з теми "RHE"

Beddaoui, Margaret. "Functional Recovery Following Regeneration of rhe Damaged Retina in the Adult Newt, Notophthalmus Viridescens." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19904.

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A hallmark of retinal diseases is degeneration of neural cells, leading to subsequent vision loss. For such diseases, replenishment of functional neural cells may be an optimal therapy. Unlike humans, the adult red-spotted newt, Notophthalmus viridescens, possesses the remarkable ability to regenerate a complete retina following its removal or injury. The purpose of this study was to develop a reproducible model of retinal damage and regeneration in the newt to understand the process of retinal regeneration. Intense light, shown in other organisms to be a relevant model of visual cell loss, was tested in the newt and resulted in variable loss of retinal function, correlating with the appearance of apoptotic cells. Due to the variability of damage observed, surgical removal of the retina was used to complement the light-damage model. A novel and non-invasive protocol using full-field electroretinography was developed to assess retinal function in vivo following damage. Measures of retinal function with the electroretinogram protocol successfully showed that photoreceptor function is initially lost and subsequently restored during regeneration. These results enhance our understanding of retinal regeneration in the adult newt and serve as a starting point for further studies aimed at determining the molecular mechanisms involved in the regeneration process.

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Bazán, Ramírez Aldo. "Comparative assessmenr in differenr condirions of a program for rhe learning of reading and writing." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/102111.

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Анотація:

Dara collected under differenr didacric condirions and evaluarion steps of a program for the learning of reading and wriring are reponed. The firsr didacric condirion corresponds ro an inirial phase of projecrion ro rhe communiry wirh rhe reachers help (Mares, Plancarre y Rueda, 1994). The second evaluarion is about a tesr applied in four experimemal programs designed by Mares et. al. based en rhe behavioral taxonomy developed by Ribes and Lopez (1985). Finally, rhe rhird condition corresponds ro rhe adaptarion of a reading and writing program for 40 children (Mares, Bazan and Farfan, 1995). In all cases, rhe effecriveness of rhe program was measured based en rhe mechanical and funcrional aspecrs of rhe wrirren language, and a comparison wirh other programs used by a differem group of reachers was established.
Se reportan los datos obtenidos en diferentes condiciones didácticas y/o momentos de evaluación de un programa de enseñanza de la lecto-escritura con perspectiva interconductual. La primera condición didáctica evaluada, corresponde a una fase inicial de proyección del programa como apoyo a la actividad del docente (Mares, Plancarte y Rueda, 1994). La segunda evaluación se refiere, a una prueba realizada sobre cuatro programas experimentales diseñadas por Mares y et al., con base en la taxonomía de la conducta elaborada por Ribes y López (1985). Finalmente, la tercera condición evaluada corresponde a una adecuación del programa de lecto-escritura a grupos de 40 niños (Mares, Bazán y Farfán, 1995). En todas las ocasiones la efectividad del programa se midió con base en los aspectos mecánicos y funcionales de la lengua escrita y, se estableció una comparación con otros programas utilizados por un grupo diferente de docentes.

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Pedrosa, Tatiana do Nascimento. "Desenvolvimento de epiderme humana reconstruída (RHE) como plataforma de testes in vitro para irritação, sensibilização, dermatite atópica e fotoimunossupressão." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-02022017-155625/.

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O desenvolvimento de novos modelos de pele e novas metodologias in vitro segue uma tendência mundial na busca pela redução ou substituição de testes em animais. Nesse contexto, kits de epiderme humana reconstruída (RHE) apresentam-se como uma plataforma promissoras para essa proposta e, alguns modelos encontram-se validados para ensaios de irritação e corrosão cutânea in vitro. Entretanto, em países como o Brasil, enfrentam-se questões alfandegárias e perda do material por perecibilidade, dificultando e até impedindo, a importação desses kits para utilização por parte das indústrias e laboratórios nacionais. Em contrapartida, o desenvolvimento de um modelo de RHE apresenta-se como um avanço tecnológico e ganho de autonomia para esses países. Assim, no capítulo 1 explorou-se o desenvolvimento de um modelo nacional de RHE (USP-RHE) que atendesse às exigências internacionais descritas no guia OECD 439. O modelo desenvolvido apresentou uma epiderme bem diferenciada e atendeu aos parâmetros de qualidade (histologia, viabilidade e função barreira) bem como da funcionalidade, a qual é expressa na capacidade de distinção entre irritantes e não irritantes, apresentando 85,7% de especificidade, 100% sensibilidade e 92,3% de acurácia quando comparada com a classificação in vivo obtida pelo ensaio do linfonodo local (LLNA). No capítulo 2, células monocíticas THP-1 em monocamada foram capazes de distinguir entre agentes sensibilizantes e não sensibilizantes por meio da expressão de CD86, CD54 e liberação de IL-8. Após a obtenção de RHE e THP-1 funcionais, um cross-talking foi estabelecido gerando uma RHE imunocompetente. A RHEI distinguiu satisfatoriamente entre agentes sensibilizantes e não sensibilizantes por meio da expressão de CD86 e CD54 na membrana das células THP-1. A liberação de IL-8 também foi avaliada na RHEI, mas, não demonstrou ser um bom indicador para a avaliação de sensibilização, ao contrário de IL-1α, que distinguiu satisfatoriamente agentes sensibilizantes de não-sensibilizantes, mas não foi capaz de hierarquizá-los. No capítulo 3, avaliou-se o papel de interleucinas do tipo Th2 e da depleção de colesterol na membrana plasmática no desenvolvimento de características morfológicas e moleculares da dermatite atópica (DA) in vitro em um modelo de RHE. Os resultados demonstram que o uso de IL-4, IL-13 e IL-25 em combinação com a depleção de colesterol na membrana plasmática mimetiza in vitro, as principais características da DA. No capítulo 4, buscou-se avaliar os efeitos imunossupressores da radiação ultravioleta na RHEI. Os ensaios foram realizados em diferentes períodos de exposição, entretanto, não foi possível observar tais efeitos. Os resultados justificam-se pela ausência da liberação de IL-10 pelo RHE imunocompetente, por exemplo, e demonstram uma limitação do RHE imunocompetente para avaliações de inativação da reposta imune. Neste trabalho, concluímos que foi possível obter uma RHE competitiva, similar aos modelos internacionais validados e que pode ser utilizada como plataforma para ensaios de irritação e sensibilização cutânea, além de ser uma plataforma para estudos da dermatite atópica. No modelo é possível estudar a ativação do sistema imune, o que o torna promissor como uma plataforma para avaliação de resposta imunológica in vitro. Conclui-se, portanto, que os objetivos foram amplamente atendidos além de oferecermos um protocolo de livre acesso para reprodução por outros laboratórios e um modelo para validação futura.
The development of new in vitro skin models and new methodologies follows a global trend in search for reductions or replacement of animal testing. In this context, Reconstructed Human Epidermis kits (RHE) are presented as a promising platform in the search for alternative methods to animal use, and some models are validated for skin irritation and corrosion in vitro tests. However, in countries such as Brazil, who face customs issues and loss of material due to perishability, making it challenging and even compromising the importation of these kits for use by industries and laboratories. In contrast, the development of an RHE model is presented as a technological breakthrough and gain of autonomy for these countries. Thus, in Chapter 1 we explored the development of a national model of RHE (USP-RHE) that meet international requirements described in OECD TG 439. The developed model presented a well-differentiated epidermis and met the quality parameters, for instance, histology, viability, and barrier function as well as the functionality expressed in the capacity of screening between irritants and nonirritants, with 85.7 % of specificity, 100 % of sensitivity and 91.7% of accuracy in comparision to in vivo UN GHS classification from Local limph node assay (LLNA). In chapter 2, monocytic THP-1 cell line, as monolayers, were able to distinguish between sensitizers and non-sensitizers by expression of CD86, CD54, and IL-8 release. In this model, functional RHE and THP-1 were used in a cross-talking, and thus an immunocompetent RHE (RHEI) was generated. The RHEI has distinguished satisfactorily between sensitizers and non-sensitizers through CD86 and CD54 expression that was larger and more sensitive in this model. The release of IL-8 was also evaluated in RHEI, however, did not demonstrate to be a good parameter for this evaluation, unlike IL-1α, which satisfactorily distinguished sensitizers from non-sensitizers, but was not able to hierarchize them. In chapter 3, we evaluated the role of Th2-related cytokines and plasma membrane cholesterol depletion (CD) in the development of atopic dermatitis (AD) morphological and molecular characteristics in an in vitro model of RHE. The results showed that combination of IL-4, IL-13 and IL-25 in combination with CD can reproduce the major features of AD in vitro. In Chapter 4, we sought to evaluate the ultraviolet radiation-induced immunosuppressive effects in RHE. The tests were performed at different times. However, it was not possible to observe such effects. The results are justified by the absence of IL-10 release by RHEI, for example, and show a limitation of RHEI for rating inactivation of the immune response. In this work, we conclude that it was possible to obtain a competitive RHE similar to the validated international models that can be used as a platform for irritation and skin sensitization tests, besides being a platform for the study of atopic dermatitis. Using this model is possible to explore the activation of immune system, which makes it promising as a platform for the evaluation of immune response in vitro. We conclude, therefore, that the objectives have been met as well as it is offering an open source protocol for breeding by other laboratories, thus offering the RHE model developed here for future validation tests.

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Lages, Joana Pestana. "À espera no bairro do talude militar. Reflexões sobre o direito à habitação." Master's thesis, Faculdade de Arquitectura de Lisboa, 2011. http://hdl.handle.net/10400.5/3300.

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Tese de Mestrado em Arquitectura
Após três décadas sobre as primeiras medidas de repressão à a construção clandestina e 15 anos de vigência de um regime de excepção, subsistem bairros precários fruto de acções espontâneas de populações com carência a nível habitacional. As políticas de habitação alvo de revisão bibliográfica nesta dissertação, nem sempre souberam responder em tempo útil e de forma definitiva à exclusão social e à necessidade de habitação condigna, direito consagrado na Constituição Portuguesa. Debruçando-se sobre a condição urbana actual, em estreita articulação com a sociedade contemporânea, a dissertação foca o olhar nas questões da habitação e aponta estratégias possíves de intervenção que sigam abordagens mais flexiveis e participativas, fruto de um modo de construir cidade mais reflexivo que possa responder eficazmente a dois direitos fundamentais: o direiro à cidade e o direito à habitação. No bairro do talude militar em Unhos, área urbana crítica da periferia da área metropolitana de Lisboa, considerada "insusceptível de reconversão", os moradores maioritáriamente de origem cabo-verdiana, esperam pelo realojamento desde 1993. Usado como caso de estudo, o bairro serviu de palco para a realização de várias actividades que permitiram traçar reflexões sobre o processo de realojamento já iniciado e sobretudo sobre o processo de realojamento que ainda está por concluir.
After three decades on the first steps to suppress illegal settlements, there are still slums as the result of spontaneous actions of people with housing deficit. Housing policies were not able to react on time and in a definitivr way to social exclusion way to social exclusion and need for adequate housing, a right under the Portuguese Constitution. Focusing on the actual urban condition, in close cooperation with contemporary society, this work converge to the housing topic, pointing possible strategies of intervention in the pursuit of more flexible and participatory approaches, as a result of a more reflexive way of building the city and respond to fondamental rights: the right to the city and the right to housing. Located in Unhos, talude militar is considered a critical urban area on the outskirts of Lisbon's larger urban zone. This area is regarded as incapable of renovation and the population, mostly from the archipelago of Cape Verde, is waiting for resettlement since 1993. Used as case study, the neighbourhood acted as stage to perform a range of activities that allowed us to draft reflections on the process of recolocation that already started, but especially on the process of recolocation that is still in progress.

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Dromantas, Marius. "Vidaus degimo variklių alternatyvių degalų efektyvumo lyginamoji anlizė." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050627_125637-70710.

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This article presents the comparative bench testing results of a naturally aspirated, four stroke, four cylinder, water cooled, direct injection Diesel engine when runing on Diesel fuel and shale oil that is produced in Estonia from local oil Shale. The purpose of this research is to investigate the possibility of practical usage of the shale oil as the alternative fuel for a high speed Diesel engine as well as to evaluate the combustion efficiency, brake specific fuel consumption, emission composition changes and the smoke opacity of the axhausts.

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Rainer, Franz. "Origen y andanzas del término económico dita. Origin and vicissitudes of the business term dita." Consejo Superior de Investigaciones Científicas, 2019. http://dx.doi.org/10.3989/rfe.2019.006.

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The etymology of the business term dita, which survives in America and in Andalusia, is still considered unresolved in the online version of the dictionary of the Real Academia. Over a hundred years ago, Cuervo proposed an Italian origin, while Corominas later preferred a Catalan origin. In this article, I intend to show that the term indeed has Italian roots, but entered Spanish via Catalan. I will also argue that the hypotheses put forward by Cuervo and Corominas concerning the concrete word that served as a model were incorrect. The correct etymon is Italian detta, which in the Middle Ages referred to the words pronounced by a banker when transferring Money from one account to another.

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Gonçalves, Ana Rosária Oliveira. "Procedimentos de licenciamento de utilizações de água nas regiões hidrográficas do Sado e Mira (RH6) e do Guadiana (RH7)." Master's thesis, Universidade de Évora, 2012. http://hdl.handle.net/10174/18244.

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Actualmente a água é um valor patrimonial ecológico e social que satisfaz funções em detrimento do seu uso. Face a este modelo, é necessário efetuar uma gestão integrada de recursos naturais, onde a água desempenha um papel decisivo. O presente quadro legal e institucional português, assente na Directiva Quadro da Água, aponta claramente para uma visão de protecção e utilização sustentável das massas de águas subterrâneas e de superfície, quer sejam interiores, estuarinas ou costeiras. Nesta perspectiva, visando a melhoria contínua dos serviços prestados, apostando na modernização e simplificação administrativa para uma utilização eficiente e sustentável das águas, procede-se à organização metódica, coerente e integrada dos procedimentos de licenciamento no âmbito da utilização dos recursos hídricos para captação de águas existentes nas regiões hidrográficas do Sado e Mira (RH6) e do Guadiana (RH7), afectas à Administração da Região Hidrográfica do Alentejo, I.P. Esta estrutura de procedimentos sistematiza os trâmites associados aos procedimentos legais e técnicos, desde a formalização da instrução de pedido, à decisão e consequente emissão de título. Adoptando uma perspectiva de consistência na tramitação dos processos de licenciamento, pretende-se formalizar nesta metodologia, uma ferramenta, para utilizadores e técnicos superiores da administração pública, que possibilite maior celeridade e eficácia na apreciação processual, bem como minimizar constrangimentos ao desenvolvimento das actividades associadas e/ou dependentes de captações de água; ABSTRACT: Nowadays water is an ecological and social heritage with functions determined by its use. This model requires natural resources integrated management, where freshwater plays a decisive role. The portuguese present institutional and legislative framework, regulations that transpose the Water Framework Directive, lead to protection and sustainable use of inland surface waters, transitional waters, coastal waters and groundwater. Hence, in order to improve official services for a simpler and more modern administration, aiming efficient and sustainable use of water, this procedures establishes a coherent and methodical organization of water use permit procedures for Sado and Mira (RH6) and Guadiana (RH7) river basin districts, in the Administração de Região Hidrográfica do Alentejo, I.P. area. This methodology gathers water permit legal and technical procedures, from the request to permit issuance. This guide to both water users and permit writers will ensure consistency in procedures in order to create a faster and effective review instrument and minimize water abstraction dependent activities constraints.

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Laura, Antonovic. "Radiobiological end-points for the theoretical evaluation of the effectiveness of carbon ions and photons in treating tumours with dynamic hypoxia." Doctoral thesis, Stockholms universitet, Fysikum, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102731.

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Tumours are characterised by unorganised vasculature, which often results in hypoxic regions. Hypoxia is a common cause for photon radiotherapy (RT) treatment failure, as hypoxic cells require up to 2-3 times higher doses compared to well-oxygenated cells for the same effect in terms of cell kill. The increase in dose that would be required to treat the tumours of cancer patients is limited by the radiation sensitivity of surrounding normal tissues. Using carbon ions instead of photons, the radiation dose can be conformed to the tumour to a much higher degree, resulting in an improved sparing of normal tissues. In addition, carbon ions have a much higher radiobiological effectiveness near the end of their range, which is positioned in the tumour. Also, the radiation modes of action leading to cell death when carbon ions interact with living tissues, are less sensitive to the oxygen status compared with the action modes of photons. The focus of this thesis lies in the development of models for the computation of the cell surviving fraction and tumour control probability (TCP) in hypoxic tumours after photon and carbon ion RT. The impact of fractionation was evaluated with regard to possible spatial changes in oxygenation, both for stereotactic body RT and for carbon ion RT. The feasibility of a method to determine and deliver the optimal photon dose for achieving a high TCP according to spatial variations in radiation sensitivity was evaluated in a treatment planning study. The radiobiological models were finally used for the theoretical quantification of the gain in using carbon ions instead of photons. The results show that there are great possibilities to increase the number of positive outcomes of radiation treatment of tumours if the key influential factors are taken into account, such as level and distribution of hypoxia, radiation quality and choice of fractionation schedule.

At the time of the doctoral defence the following papers were unpublished and had a status as follows; Paper 3: Manuscript; Paper 4: Epubl ahead of print; Paper 5: Manuscript

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Call, Whitney Marissa. "Rae, Baby." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3413.

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This thesis is a young adult fictional novel from the perspective of Rachel Jackson, or Rae, a seventeen year-old girl with Williams Syndrome, a rare developmental disorder caused by missing genes on chromosome 7 that causes those with it to lack logical connections, yet possess very gregarious, social, and musical personalities. Think of it as an inverted form of autism. At the genesis of the novel, Rae becomes pregnant. Upon misunderstanding her mother's sugar-coated reasoning for giving the baby up for adoption, Rae spends the novel trying to find a man to marry so that, in her understanding, she may keep her child. Along her journey, Rae meets Theo, a well-meaning Christian boy, who appears to be a possible match. Rae falls in love with Theo and gets into various kinds of trouble as she discovers how to take care of herself as well as how to accept herself, disorder and all. Along with her hardworking mother, her feisty grandmother, and her sassy little sister, Rae endeavors this bildungsroman to discover who she is and how she fits into society.

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Rodrigues, Artemis Socorro do Nascimento. "Caracterização molecular dos antigenos RhD, (RhD fraco e RhD parcial) e sua aplicação na pratica transfusional." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310418.

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Orientador: Lilian Maria de Castilho
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-04T11:27:19Z (GMT). No. of bitstreams: 1 Rodrigues_ArtemisSocorrodoNascimento_D.pdf: 9543028 bytes, checksum: 5774a3716484ea2212070f20c266a89f (MD5) Previous issue date: 2005
Resumo: Considerando a imunogenicidade e importância clínica do antígeno RhD bem como o grande número de variantes RhD identificadas, estudos que possam esclarecer sua expressão e mecanismos moleculares envolvidos são importantes para a padronização de técnicas moleculares e sorológicas em diferentes populações. Assim foram nossos objetivos: padronizar técnicas moleculares para realização da genotipagem RHD fraco e determinar sua ocorrência na população brasileira; associar os tipos de RhD fracos encontrados com os haplótipos Rh presentes; e avaliar a aplicação da determinação do antígeno RhD na prática transfusional. Estudamos 503 amostras de DNA de doadores voluntários de sangue fenotipados como RhD ftaco. Destas amostras de DNA estudadas, 415 (82,5%) foram caracterizadas como RhD ftaco, 65 (12,9%) como RhD parcial, 15 (3%) apresentaram associações de RhD parcial e RhD ftaco e 8 (1,6%) foram RhD normal. I Os antígenos RhD fraco tipos 1, 3 e 4 foram os mais fteqüentes em nossa população. Como estes três tipos de RhD fraco não apresentam risco de aloimunização anti-D, pacientes assim classificadospodem ser transfundidos com sangue RhD-positivo. Nossos resultados demonstraram que 12,~A>das amostras fenotipadas como RhD fraco eram na verdade RhD parcial. Os antígenos RhD parciais encontrados em nosso estudo foram D~ DHMi e DVI. Quarenta (7,9%) amostras de DNA foram caracterizadas como D~ 16 (3,2%) como DHMi e 9 (1,8%) como DVI. A caracterização dos antígenos RhD parciais que reagem sorologicamente como RhD ftaco, tais como D DHMi e RhD categoria VI pode ser de grande auxilio na prevenção da aloimunização anti-D em pacientes politransfundidos e gestantes. A freqüência dos antígenos RhD parciais D~ DHMi e DVI encontrada em nossas amostras sugere um elevado risco de aloimunização ao antígeno RhD em pacientes fenotipados como RhD ftaco. - Das 503 amostras estudadas, 15 apresentaram mutações responsáveis pela expressão do antígeno RhD fraco e ao mesmo tempo mutações características de antígenos RhD parciais, ou seja, estas amostras possuíam os antígenos RhD fraco e RhD parcial associados. Estudamos quatro amostras de DNA de pacientes fenotipados como RhD :fraco que apresentavam anti-D. Nosso estudo demonstrou que a aloimunização anti-D nestes pacientes estava relacionada à presença de um antígeno RhD parcial e não a um antígeno RhD :fraco como diagnosticado sorologicamente. Duas amostras foram classificadascomo RhD parcial DAR, 1 como RhD parcial DHMi e 1 como DVI. Os resuhados demonstraram que os tipos de RhD fraco 1, 2, 3 e 4 que foram detectados à TA ou à 3'te e apresentaram grau de aglutinação superior a 1+ na AGH podem ser considerados como RhD positivo, pois não foram associados ao antígeno RhD parcial. Apesar deste trabalho ter sido o único que relacionou os tipos de RhD ftaco com o grau de aglutinação, a literatura revela que ainda não foi demonstrada aloimunização anti-D em pacientes portadores dos antígenos RhD fraco tipos 1,2 e 3. De acordo com os nossos resultados pode-se concluir que: 1. A transfusão com sangue RhD-positivo pode ser recomendada para todos os pacientes que apresentam os tipos do antígeno RhD :ftaco 1, 3 e 4 identificados por técnicas moleculares e para aqueles que apresentarem grau de aglutinação superior a 1+ na fenotipagem RhD. 2. A utilização de métodos de fenotipagem mais sensíveis em combinação com reagentes anti-D de alta afinidade é recomendada na detecção de antígenos RhD ftaco com baixa densidade antigênica em doadores de sangue; 3. Há necessidade da utilização de dois anti-soros monoc1onais (IgM e IgG) na determinação do antígeno RhD :ftacoem pacientes; 4. As genotipagens RHD, RHD ftaco e RHD parcial devem ser rea1i73dasquando os resuhados sorológicos não forem claros ou quando o paciente for politransfundido. 5. A biologia molecular associada à hemaglutinação pode aumentar consideravelmente a segurança transfusional pela mellior caracterização dos antígenos RhD em nossa população
Abstract: The purpose of this study was to characterize by molecular studies theRhD antigens (weak D and partial D) in Brazilian blood donors. DNA samples ftom 503 blood donors phenotyped as weak D were tested by two different sequence-specific primers (pCR-SSP) assays to determine the presence or absence of RHD gene (PCR-SSP intron 4 and exon 10) and to detect the common weak D types. Ofthe 503 weak D samples studied, 415 (82,5%) were identified as weak D, 65 (12,9%) as partial D, 15 (3%) showed association ofweak D and partial D and 8 (1,6%) were normal D. Weak D types 1, 3 and 4 contributed more than 85% of alI molecular weak D types. For these 3 types, D-positive transfusion can be considered safe because no immunization events have been documented yet. These findings show for the first time the frequency of weak D types in Brazilians. Molecular analysis showed that 12,9% of the weak D phenotype samples studied carried a partia! D alIele. The partial Ds found in our study were DAR, DVI and DHMi. Forty (7,9%) DNA samples were characterized as DAR, 16 (3,8%) as DHMi and 9 (1,8%) as DVI. The characterization of the partia! D antigens DAR, DHMi and DVI may avoid alIoimmunization in patients phenotyped as weak D. Fiffeteen patients showed mutations to weak D and partia! D showing that these samples had the weak D and partia! D antigens associated. We also studied 4 DNA samples of patients phenotyped as weak D who had developed anti-D. Our study showed that anti-D alIoimmunization in these patients was associated with the presence of partia! D antigens. Two samples were classified as partia!, D DAR, 1 as DHMi and 1 was DVI.AlI the weak D types identified in our study were associated with the intensity of agglutination obtained at room temperature (RT), 3'fC and AGH. The sensitivity of detecting weak D depends on the anti-D reagent and on the exact conditions of the methods. Our results showed that the weak D types 1, 2, 3 and 4 were frequently detected at RT and 3'fC and therefore could be considered as D-positive for transfusion. According to our results we could recommend the use ofmonoclonal anti-DIgM with high avidity to detect weak D antigen with low antigen density in blood donors and two monoclonals, one IgM and one IgG in combination with AGT to detect the weak D antigen in patients
Doutorado
Ciencias Basicas
Doutor em Clínica Médica

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Книги з теми "RHE"

Ūʺ, Moṅʻ Moṅʻ Khyacʻ. Rhe ̋hoṅʻ ̋ ʾa mraṅʻʹ mruiʹ. (Ranʻ kunʻ): Puṃ nhipʻ re ̋nhaṅʻʹ Cā ʾupʻ thutʻ ve reG lupʻ ṅanʻ,̋, 2004.

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Gabrea℗ĐhRadu. Werner Herzog et la mystique rhe nane. Lausanne: L'Age d'Homme, 1986.

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Coussot, Philippe. Rhe ophysique des pa tes et des suspensions. Les Ulis [Essonne]: EDP Sciences, 1999.

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Jacobs, Leah. Dating secrets: Rhe ultimate guide to finding your spouse. New York: Shaar Press, 2006.

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Fumaroli, Marc. He ros et orateurs: Rhe torique et dramaturgie corne liennes. Gene ve: Librairie Droz, 1990.

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Death in a red canvas chair: A Rhe Brewster mystery. North Charleston, South Carolina: CreateSpace Independent Publishing Platform, 2004.

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Pvaṇʻʹ, Canʻʺ. Rhe ̋mranʻ mā maṅʻ ̋myā ̋lakʻ thakʻ thokʻ lhamʻ ̋re ̋. (Ranʻ kunʻ ): Ū ̋ʾOṅʻ Joʻ, 2004.

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Noṅʻ, Saṅʻʹ. Rhe ̋hoṅʻ ̋sa muiṅʻ ̋vaṅʻ Suṃ ̋chayʻʹ suṃ ̋chū Cetī toʻ. Kyokʻ taṃ tā,̋ Ranʻ kunʻ: Yuṃ krañÑʻ khyakʻ Cā pe, 2005.

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Nī, Paṅʻ. Yaṅʻʺ khyoṅʻʺ ripʻ, ʼaṅʻ tuiṅʻʺ mre, nhaṅʻʹ ʼa rhe mrokʻ le. Ranʻ kunʻ: Mī sāʺ cu Cā cañʻ, 1986.

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Saccā. Mranʻ māʹ rhe ̋hoṅʻ ̋maṅʻ cā nhaṅʻʹ Mranʻ māʹ yañʻ kye ̋mhu. (Ranʻ kunʻ): Puṃ nhipʻ re ̋nhaṇʻʹ cā ʼupʻ thutʻ ve re ̋lupʻ ṅanʻ,̋, 2004.

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Gooch, Jan W. "Rhe." In Encyclopedic Dictionary of Polymers, 631. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_10021.

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Bährle-Rapp, Marina. "...rhe." In Springer Lexikon Kosmetik und Körperpflege, 475. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_8903.

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Bährle-Rapp, Marina. "...rhoe, -rhö, -rhoea, -rhe." In Springer Lexikon Kosmetik und Körperpflege, 476. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_8909.

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Cowan, Jake. "Topology and Psychoanalysis: Rhe-torically Restructuring the Subject." In Topologies as Techniques for a Post-Critical Rhetoric, 151–74. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51268-6_8.

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Jiang, Huiyu, Liang Wang, Xianping Tao, and Hao Hu. "RHE: Relation and Heterogeneousness Enhanced Issue Participants Recommendation." In Web Information Systems and Applications, 605–16. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-87571-8_52.

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Baker, Thomas L., and Charles F. Hofacker. "Marketing When Payment is Voluntary: Rhe Case of "Shareware"." In Proceedings of the 1989 Academy of Marketing Science (AMS) Annual Conference, 298–302. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17055-8_61.

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Murthy, P. Balakrishna, A. Sairam Kishore, and P. Surekha. "Assessment of In Vitro Skin Irritation Potential of Nanoparticles: RHE Model." In Methods in Molecular Biology, 219–34. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-002-1_16.

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Corsini, Emanuela, Sue Gibbs, Erwin Roggen, Ian Kimber, and David A. Basketter. "Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency." In Toxicity Assessment, 13–29. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1091-6_2.

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Setijanti, Herlina B., Eka Rusmawati, Rahmi Fitria, Tuty Erlina, Rina Adriany, and Murtiningsih. "Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE)." In Alternatives to Animal Testing, 20–32. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_3.

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Alépée, Nathalie, Marie Hélène Grandidier, Carine Tornier, and José Cotovio. "An In Vitro Skin Irritation Test Using the SkinEthic™ Reconstructed Human Epidermal (RHE) Model." In Alternatives for Dermal Toxicity Testing, 59–72. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50353-0_4.

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Тези доповідей конференцій з теми "RHE"

Liu, Shaoshan, Chengrui Deng, Xiao-Feng Li, and Jean-Luc Gaudiot. "RHE: A Lightweight JVM Instructional Tool." In 2009 33rd Annual IEEE International Computer Software and Applications Conference. IEEE, 2009. http://dx.doi.org/10.1109/compsac.2009.87.

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Ye, Xuhua, Minjun Peng, and Jiange Liu. "Analysis of PRHRS for an Integral Pressurized Water Reactor Using RELAP5/MOD3.4." In 18th International Conference on Nuclear Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/icone18-29987.

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An investigation on the thermal hydraulic characteristics of the passive residual heat removal system (PRHRS) which is used in an integral pressurized water reactor (INSURE-100) is presented in this paper. The main components of primary coolant system are enclosed in reactor vessel. Primary fluid flow circle is natural circulation. The PRHRS can remove the energy from the primary side as long as the residual heat exchanger (RHE) is submerged in the emergency cooldown tank (ECT). The parameter study is performed by considering the effects of an effective height between the steam generators and the RHE and a valve actuation time, which are useful for the design of the PRHRS. The mass flow in the PRHRS has been affected by the height difference between the steam generators and the RHE. The pressure peak of the primary side and PRHRS has been affected by the valve action time.

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El-Rewini, H., and B. D. Shriver. "Introduction to rhe Software Technology Track: High Performance Distributed Systems: Design, Impleme." In Proceedings of HICSS-29: 29th Hawaii International Conference on System Sciences. IEEE, 1996. http://dx.doi.org/10.1109/hicss.1996.495439.

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Dai, Shoubao, Minjun Peng, and Jiange Liu. "Optimization and Analysis for Passive Residual Heat Removal System of an Integral Pressurized Water Reactor." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75503.

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The characteristics of passive safety systems for an integral pressurized water reactor (IPWR) are quite different from the general reactor because of special configuration and dangerous run environment. Passive residual heat removal system (PRHRS) for the IPWR with three-interknited natural coolant circulation loops, safely remove the core decay heat to the ultimate heat sink. Using RELAP5/MOD3.4 code to simulate this system during the reactor trip, analyses the steady-state and transient-state thermohydraulic behaviors for the IPWR and its PRHRS, and the effects of design parameters on the system. it is found that on the initial period of reactor trip, due to the establishment of the natural circulation in three loops uncompleted, the secondary loop pressure have the peak value. Through analyzing the effects of design parameters on the system, the PRHRS are optimized. The results show that the larger the residual heat exchanger (RHE) heat transfer area and the higher the height difference between the steam generator and the residual heat exchanger, the easier the establishment of the natural circulation in the third loop, but which make the peak value of the secondary loop pressure higher. According to set the compensating water tank, which is parallel connected to the RHE, can lighten the higher the peak value of the secondary loop pressure, and optimize the design of PRHRS.

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Toba, Daiki, Hiroya Mamori, Naoya Fukushima, and Makoto Yamamoto. "ICING STUDY OF SUPER COOLED WATER DROPLET IMPINGING ON AIRFOIL USING E-MPS METHODD." In 3rd Thermal and Fluids Engineering Conference (TFEC). Connecticut: Begellhouse, 2018. http://dx.doi.org/10.1615/tfec2018.rhe.021654.

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Kharel, Prabhuti, Rahmatul Mahmoud, and Kunal Mitra. "RHEOLOGICAL ANALYSIS OF CELL EMBEDDED HYDROGEL BIO-INK FOR EXTRUSION BIOPRINTING." In 3rd Thermal and Fluids Engineering Conference (TFEC). Connecticut: Begellhouse, 2018. http://dx.doi.org/10.1615/tfec2018.rhe.021751.

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Zhou, Xiangyang. "Atomistic Modeling of Conduction and Transport Processes in Micro-Porous Electrodes Containing Nafion Electrolytes." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18116.

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Atomistic modeling and/or experimental methods were conducted to study transport processes in the porous electrodes of polymer electrolyte fuel cells (PEFCs) and of mediator enhanced polymer electrolyte supercapacitors (MEPESCs). The simulations show that vibrations of the Pt nanocrystallines on rhe carbon supports significantly impacts diffusion in the Nafion electrolyte clusters between the carbon supports and enhances the diffusivity of hydrogen, oxygen, methanol, water, and hydronium up to 8 times the nominal value. Charging the carbon support alters the diffusivities. It was visualized that charging of Pt nanocrystallines resulted in disintegration of the Pt catalysts leading to a reduction in catalytic activity of the catalyst layer. Re-precipitation and re-crystallization of the Pt under a full discharging condition can also be visualized using the molecular dynamics (MD) modeling method. MD simulations also indicate that the mobility of the iodine mediators is at least 10 times greater than other small ions in the Nafion electrolyte. The degradation of the MEPESC is dominated by the crossover of I− ions but not I2 in Nafion.

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Zhao, Lei, and Ting Wang. "Simulation of Char Dust Combustion Inside a Pyroscrubber Downstream of a Petroleum Coke Calcining Kiln." In 2010 14th International Heat Transfer Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ihtc14-23053.

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A pyroscrubber is a furnace used in the petroleum coke calcining industry to recover energy from the carbonaceous contents, including char dust and hydrocarbon volatiles of the exhaust gas from the calcination kiln. The combusted hot gases are used to generate steam and produce electricity, so it is important to optimize the pyroscrubber performance to produce high-grade combusted gases to generate steam but with minimal emissions. A previous study employed the locally-homogeneous flow (LHF) model to study rhe means to improve combustion efficiency and reduce emissions. In the LHF model, the inter-phase exchange rates of mass, momentum and energy are assumed to be infinitely fast, so the dispersed phase (char dust) can be simplified as the gas phase, and the complex two-phase flow is then treated as a single-phase flow. In this study, LHF model is replaced with a solid particle combustion model by incorporating both finite-rate heterogeneous and homogeneous combustion processes. Results reveal that the particle combustion model generates much higher local flame temperature (2200K) than in LHF model (1800K). All char particles are burned before or in the high-bay area. Total energy output of the case with particle combustion model is 92% of the LHF model. Furthermore, motivated by the potential energy saving from removing the air blower power supply, this study further investigates the possible benefit of running the pyroscrubber with the ventilation doors open. Three cases with different combinations of air injections and door opening have been studied. Results show that the gas flow is stably stratified with a large amount of the entrained cold air moving at the bottom of the chamber and the hot combusted gas moving through the top. With bottom doors completely open, sufficient air can be drawn into the pyroscrubber without the need of blowing air in, but the combustion gases will be overcooled making this practice unfavorable from the energy saving point of view.

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Bi, Feng, Yajie Zhu, and Qiulin Tang. "Abstract 2146: The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2146.

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Belinić, Barbara, and Petra Šantek. "Detailed design of stage a Križevci-Koprivnica railway corridor." In 7th International Conference on Road and Rail Infrastructure. University of Zagreb Faculty of Civil Engineering, 2022. http://dx.doi.org/10.5592/co/cetra.2022.1391.

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Due to its great geological and transport position, Croatia is part of important international transport corridors and was included in the Trans-European Transport Network when it joined the European Union. The next ten years will be marked by investments in railway infrastructure projects worth an estimated 4.4 billion euros. One of the most important and financially challenging investments are the RH1 and RH2 corridors. Part of the RH2 corridor is the Križevci-Koprivnica line, which runs under the M201 railway line. The construction of the Križevci-Koprivnica line is divided into four stages. The subject of this article is the description of the substructure, drainage and objects of Stage A from Križevci station to Lepavina station. The biggest horizontal reconstruction is expected in front of Lepavina station. The reconstruction of the horizontal and vertical geometry will allow passengers to travel faster, up to 160 km/h. Major infrastructural investments in railways are just around the corner and will bring benefits, both to individuals and society. Future rail passengers can expect safer, more comfortable and faster transport. Better mobility of passengers and goods will promote the development of Croatian regions as well as demographic and economic progress.

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Звіти організацій з теми "RHE"

Sochat, V. RSE-Ops. Office of Scientific and Technical Information (OSTI), July 2021. http://dx.doi.org/10.2172/1806426.

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Simandl, G. J., R. J. D'Souza, S. Paradis, and J. Spence. Rare-earth element content of carbonate minerals in sediment-hosted Pb-Zn deposits, southern Canadian Rocky Mountains. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/328001.

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Paleozoic platform carbonate rocks of the Rocky Mountains host Mississippi Valley-type (MVT), magnesite, barite, and REE-barite-fluorite deposits. Farther west, platform carbonate rocks of the Kootenay Arc host MVT and fracture-controlled replacement (FCR) deposits. This is the first systematic LA-ICP-MS study of carbonates in MVT and FCR deposits. We investigated seven MVT deposits in the Rocky Mountains, and five MVT deposits in the Kootenay Arc. None of the post-Archean Australian shale (PAAS)-normalized REE profiles show light REE (LREE) depletion and strong negative Ce anomalies characteristic of modern seawater: some profiles are nearly flat; others show depletion in LREE similar to seawater but without negative Ce anomalies; others are middle REE enriched. Carbonates with a strong positive Eu anomaly precipitated from or interacted with different fluids than carbonates with flatter profiles without a strong positive Eu anomaly. REE signatures reflect crystallization conditions of primary carbonates, and crystallization and re-equilibration conditions of carbonates with ambient fluids during diagenesis, deep burial, and/or metamorphic recrystallization. Chemical evolution of fluids along their migration path, fluid-to-rock ratio, fluid acidity, redox, and temperature also influence REE profile shape, which helps establish genetic and timing constraints on studied deposits and improves knowledge of the metallogeny of the Kootenay Arc and Rocky Mountains.

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Miller, Bradford W. The Rhet Programmer's Guide (For Rhet Version 17.9). Fort Belvoir, VA: Defense Technical Information Center, December 1990. http://dx.doi.org/10.21236/ada248961.

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Falk, A. Comment on Extracting alpha from B to rho rho. Office of Scientific and Technical Information (OSTI), October 2003. http://dx.doi.org/10.2172/826521.

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Bevan, A. Measurements of sin2 alpha phi_2 from B to pi pi, rho pi and rho rho Modes. Office of Scientific and Technical Information (OSTI), November 2004. http://dx.doi.org/10.2172/839802.

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Palen-Michel, Madison. Rue Saint-Jacques. Ames: Iowa State University, Digital Repository, February 2013. http://dx.doi.org/10.31274/itaa_proceedings-180814-589.

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Katz, R. Theory of RBE. Office of Scientific and Technical Information (OSTI), July 1989. http://dx.doi.org/10.2172/5408679.

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Heer, T. RCE CI, Contractor Services. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1670558.

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Aubert, B. Observation of e+e- Annihilations into the C=+1 Hadronic Final States \rho^0\rho^0 and \phi\rho^0. Office of Scientific and Technical Information (OSTI), June 2006. http://dx.doi.org/10.2172/885278.

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Li, H. Constraints on the CKM Angle alpha in the B to rho rho Decays. Office of Scientific and Technical Information (OSTI), November 2004. http://dx.doi.org/10.2172/839589.

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