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Добірка наукової літератури з теми "Risk of recurrence"

Автор: Grafiati

Опубліковано: 6 липня 2024

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Статті в журналах з теми "Risk of recurrence"

Park, Joonseon, Il Ku Kang, Ja Seong Bae, Jeong Soo Kim, and Kwangsoon Kim. "Clinical Significance of the Lymph Node Ratio of the Second Operation to Predict Re-Recurrence in Thyroid Carcinoma." Cancers 15, no. 3 (January 19, 2023): 624. http://dx.doi.org/10.3390/cancers15030624.

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The purpose of this study was to establish the risk factors for re-recurrences and disease-specific mortality (DSM) in recurrent thyroid cancer. Patients with recurrent thyroid cancer who underwent initial thyroid surgery from January 2000 to December 2019 at Seoul St. Mary’s Hospital (Seoul, Korea) were assessed. Clinicopathological characteristics and long-term oncologic outcomes were compared between patients with one recurrence (n = 202) and patients with re-recurrences (n = 44). Logistic regression and cox-regression analyses were conducted to determine the risk factors for re-recurrences and DSM, respectively. Receiver-operating characteristic curve analysis was performed to determine the cutoff value for lymph node ratio (LNR) as a predictor of re-recurrences. DSM was significantly higher in the re-recurrence group compared with the single-recurrence group (6.8% vs. 0.5%, p = 0.019). Surgical treatment at the first recurrence significantly lowered the risk of re-recurrences. Age (≥55), male sex, and LNR (≥0.15) were independent significant risk factors for re-recurrences in patients who underwent surgery at the first recurrence. Surgical resection is the optimal treatment for initial thyroid cancer recurrence. LNR at re-operation is more effective in predicting re-recurrence than the absolute number of metastatic LNs.

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Puhr, Hannah C., Lisbeth Eischer, Hana Šinkovec, Ludwig Traby, Paul A. Kyrle, and Sabine Eichinger. "Circumstances of provoked recurrent venous thromboembolism: the Austrian study on recurrent venous thromboembolism." Journal of Thrombosis and Thrombolysis 49, no. 4 (October 17, 2019): 505–10. http://dx.doi.org/10.1007/s11239-019-01965-z.

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Abstract Patients with unprovoked deep-vein thrombosis (DVT) of the leg or pulmonary embolism (PE) have a high recurrence risk. How often these recurrences are provoked by a temporary risk condition is unknown. In a cohort of patients with unprovoked venous thromboembolism (VTE), we evaluated the clinical circumstances of recurrence. We studied patients with DVT of the leg and/or PE. End point was recurrence of objectively verified symptomatic VTE. Provoked recurrence was defined according to guidance criteria. 1188 patients were followed for a median of 8.9 years after withdrawal of oral anticoagulants. 312 patients had recurrent VTE, which was provoked in 42 (13%). Recurrence was related to a major risk factor in 19, to a minor risk factor in 22, and to a persistent risk factor in one patient(s). 14 recurrences occurred after major surgery and 5 during hospitalization. Ten recurrences occurred after minor surgery, eight after trauma and three during female hormone intake. Four recurrences occurred during heparin prophylaxis. The incidence of provoked VTE recurrence appears to be low. VTE can recur when prevention is stopped or even during thromboprophylaxis. Surgery and trauma are frequent risk factors.

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Yogi, Nikunja, Pankaj Raj Nepal, Dinesh Nath Gongal, and Upendra Prasad Devkota. "Analysis of risk factors predicting recurrence of chronic subdural hematoma." Nepal Journal of Neuroscience 15, no. 3 (December 31, 2018): 32–38. http://dx.doi.org/10.3126/njn.v15i3.23279.

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Recurrences after evacuation of chronic subdural hematoma are seen in 2-33% of cases with various surgical approaches. Various demographical, clinical, radiological, surgical and postoperative management strategies have been explored as the possible predictors of recurrence. We performed a retrospective analysis in 160 patients with chronic subdural hematoma with an aim to analyze the post-operative recurrences and factors associated with it. Various socio demographic and clinico-radiological parameters were studied against the rate of recurrence after surgery using Chi square/Fischer Exact Test. Factors showing significant association on univarate analysis were then analysed using binary logistic regression. The rate of recurrence of CSDH in our study was 5% and the mean duration of recurrence was 33 days. Chronic alcohol use (p=0.007) and intraoperative brain expansion ((p=0.001) were the two factors associated with recurrence of CSDH. On binary logistic regression chronic alcohol use (wald-6.467, p=0.011) and intraoperative brain expansion (wald=6.674, p=0.010) were both associated significantly with recurrence of CSDGH with an odds of 7.804 and 0.058 respectively.

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Shinnar, Shlomo, Anne T. Berg, Solomon L. Moshe, Christine O'Dell, Marta Alemany, David Newstein, Harriet Kang, Eli S. Goldensohn, and W. Allen Hauser. "The Risk of Seizure Recurrence After a First Unprovoked Afebrile Seizure in Childhood: An Extended Follow-up." Pediatrics 98, no. 2 (August 1, 1996): 216–25. http://dx.doi.org/10.1542/peds.98.2.216.

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Objective. To assess the long-term recurrence risks after a first unprovoked seizure in childhood. Methods. In a prospective study, 407 children who presented with a first unprovoked seizure were then followed for a mean of 6.3 years from the time of first seizure. Results. One hundred seventy-one children (42%) experienced subsequent seizures. The cumulative risk of seizure recurrence was 29%,37%,42%, and 44% at 1,2,5, and 8 years, respectively. The median time to recurrence was 5.7 months, with 53% of recurrences occurring within 6 months, 69% within 1 year, and 88% within 2 years. Only 5 recurrences (3%) occurred after 5 years. On multivariable analysis, risk factors for seizure recurrence included a remote symptomatic etiology, an abnormal electroencephalogram (EEG), a seizure occurring while asleep, a history of prior febrile seizures, and Todd's paresis. In cryptogenic cases, the risk factors were an abnormal EEG and an initial seizure during sleep. In remote symptomatic cases, risk factors were a history of prior febrile seizures and age of onset younger than 3 years. Risk factors for late recurrences (after 2 years) were etiology, an abnormal EEG, and prior febrile seizures in the overall group and an abnormal EEG in the cryptogenic group. These are similar to the risk factors for early recurrence. Conclusions. The majority of children with a first unprovoked seizure will not have recurrences. Children with cryptogenic first seizures and a normal EEG whose initial seizure occurs while awake have a particularly favorable prognosis, with a 5-year recurrence risk of only 21%. Late recurrences do occur but are uncommon.

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Flach, Clare, Walter Muruet, Charles D. A. Wolfe, Ajay Bhalla, and Abdel Douiri. "Risk and Secondary Prevention of Stroke Recurrence." Stroke 51, no. 8 (August 2020): 2435–44. http://dx.doi.org/10.1161/strokeaha.120.028992.

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Background and Purpose: With recent advances in secondary prevention management, stroke recurrence rates may have changed substantially. We aim to estimate risks and trends of stroke recurrence over the past 2 decades in a population-based cohort of patients with stroke. Methods: Patients with a first-ever stroke between 1995 and 2018 in South London, United Kingdom (n=6052) were collected and analyzed. Rates of recurrent stroke with 95% CIs were stratified by 5-year period of index stroke and etiologic TOAST (Trial of ORG 10172 in Acute Stroke Treatment) subtype. Cumulative incidences were estimated and multivariate Cox models applied to examine associations of recurrence and recurrence-free survival. Results: The rate of stroke recurrence at 5 years reduced from 18% (95% CI, 15%–21%) in those who had their stroke in 1995 to 1999 to 12% (10%–15%) in 2000 to 2005, and no improvement since. Recurrence-free survival has improved (35%, 1995–1999; 67%, 2010–2015). Risk of recurrence or death is lowest for small-vessel occlusion strokes and other ischemic causes (36% and 27% at 5 years, respectively). For cardioembolic and hemorrhagic index strokes around half of first recurrences are of the same type (54% and 51%, respectively). Over the whole study period a 54% increased risk of recurrence was observed among those who had atrial fibrillation before the index stroke (hazard ratio, 1.54 [1.09–2.17]). Conclusions: The rate of recurrence reduced until mid-2000s but has not changed over the last decade. The majority of cardioembolic or hemorrhagic strokes that have a recurrence are stroke of the same type indicating that the implementation of effective preventive strategies is still suboptimal in these stroke subtypes.

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Borger, J., H. Kemperman, A. Hart, H. Peterse, J. van Dongen, and H. Bartelink. "Risk factors in breast-conservation therapy." Journal of Clinical Oncology 12, no. 4 (April 1994): 653–60. http://dx.doi.org/10.1200/jco.1994.12.4.653.

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PURPOSE To identify clinical and pathologic factors associated with an increased risk of local recurrence following breast-conservation therapy (BCT) to assess the safety of this procedure for all subgroups of patients. PATIENTS AND METHODS The study population consisted of 1,026 patients with clinical stage I and II breast cancer treated between 1979 and 1988 at the Netherlands Cancer Institute. The BCT regimen consisted of local excision and axillary lymph node dissection (ALND) followed by whole-breast irradiation to a total dose of 50 Gy in 2-Gy fractions and boost irradiation (mostly by iridium implant) of 15 to 25 Gy. RESULTS With a median follow-up duration of 66 months, the actuarial breast recurrence rate was 4% at 5 years, counting all breast recurrences. Univariate analysis showed seven factors to be associated with an increased risk of local recurrence; age, residual tumor at reexcision, histologic tumor type, presence of any carcinoma-in-situ component, vascular invasion, microscopic margin involvement, and whole-breast radiation dose. Three factors remained independently significant after proportional hazard regression analysis: age, margin involvement, and the presence of vascular invasion. When the analysis was repeated, but counting only those breast recurrences that occurred before regional or distant failures, only young age and vascular invasion were independent predictive factors. In the third analysis, factors predicting the necessity of local salvage treatment were analyzed. In this analysis, the possible bias in the former analysis caused by censoring actuarial methods was avoided. The results were the same as in the second analysis, showing young age and vascular invasion as the only independent predictive factors. Breast recurrence rates were 6% for patients less than 40 years of age and 8% for patients with tumors showing vascular invasion. In the absence of risk factors, the breast recurrence rate is only 1% at 5 years. CONCLUSION Slightly higher recurrence rates were found in patients less than 40 years of age and in patients with tumors showing vascular invasion. The role of margin involvement is uncertain.

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Rose, Kyle M., Aram Vosoughi, Gustavo Borjas, Heather L. Huelster, Philippe E. Spiess, Anders E. Berglund, Wade J. Sexton, Anirudh Joshi, Nagi B. Kumar, and Roger Li. "Complimentary genomic, pathologic, and artificial intelligence analysis on low-grade noninvasive bladder cancer to predict downstream recurrence." Journal of Clinical Oncology 41, no. 6_suppl (February 20, 2023): 553. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.553.

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553 Background: Low-grade noninvasive (LGTa) bladder cancer is a relatively quiescent but heterogenous malignancy, characterized by downstream recurrences requiring repeated transurethral resections and frequent surveillance. Investigations to elucidate drivers of recurrence have been sparse, but will help risk-stratify patients with LGTa and allow augmentation of follow up protocols. Methods: Patients with LGTa index tumors were stratified by those with no downstream recurrences (nonrecurrent) vs. those with later recurrences (recurrent). RNA sequencing identified differentially expressed genes (DEGs), deconvoluted for cell-type using xCell. Pathologic analysis was performed by a genitourinary pathologist, then a deep-learning artificial intelligence (AI) platform was leveraged to correlate recurrence risk and recurrence-free survival (RFS) based on deep-learning algorithm of segmented nuclei. Results: Thirty index bladder tumors/patients were identified, 18 (60%) of which had later recurrence (Table). There were 238 DEGs recognized, with recurrent tumors expressing signatures for epithelial mesenchymal transition, myogenesis, TNFα signaling via NFκB, and angiogenesis. Recurrent tumors also demonstrated a higher tissue micoenvironment, stroma, and cancer-associated fibroblast score. Pathologic TME analysis validated these findings, with recurrent tumors demonstrating a higher frequency of inverted growth pattern and a higher median stroma percentage. Finally, the AI-derived signature was predictive of recurrence and risk-stratified the cohort (HR= 5.43 [95% CI 1.1-26.76]) for predicting high vs. low risk of recurrence. Patients in the high risk group had a 87.5% recurrence rate while those in the low risk group had a 28.5% recurrence rate (p<0.01). Conclusions: Using a multi-disciplinary approach, we identified key signatures in recurrent LGTa bladder cancer. Characterization of these factors is a critical first step in the risk-stratification of LGTa tumors, and may allow risk-stratification of surveillance protocols and identification of possible targets for chemoprevention trials. [Table: see text]

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Veenstra, David L., Nathaniel Hendrix, Chantal M. Dolan, Kathryn Fisher, Deepa Lalla, Nina Hill, and Beverly Moy. "Abstract P3-16-01: Population effectiveness model of the consequences of recurrence after trastuzumab emtansine (T-DM1) treatment among U.S. patients with high-risk HER2+ early-stage breast cancer (ESBC)." Cancer Research 82, no. 4_Supplement (February 15, 2022): P3–16–01—P3–16–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-16-01.

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Abstract Background: To estimate the long-term consequences of disease recurrence following treatment with adjuvant T-DM1 among U.S. patients with high-risk HER2+ ESBC who did not achieve pathologic complete response (pCR) after neoadjuvant therapy. Methods: A Markov model was used to simulate local/regional and distant recurrence with 10 years of follow-up. This corresponds to the estimated number of U.S. patients with incident high-risk HER2+ ESBC in 2021 (n = 10,000), which was derived from SEER population-based estimates, the NEOSPHERE trial and expert clinical opinion. The probability of recurrence was based on the T-DM1 arm in the KATHERINE trial and long-term results from the HERA trial. We assumed that 80% of patients with any recurrence experience distant recurrence, while the remainder have local/regional recurrence. SEER data and literature review were used to estimate probabilities of survival, distant recurrence secondary to local/regional recurrence, and direct medical costs. We estimated indirect costs were equal to 15% of direct medical costs. Model outcomes included: recurrences, breast cancer-related deaths, non-breast cancer-related deaths, direct medical costs, and indirect costs (all undiscounted). Results were compared to a scenario in which there was no recurrence to estimate population impact. All outcomes were also projected over 10 annual incident cohorts, each with 10 years of follow-up. Results: We estimated the 2021 U.S. patient cohort would experience 2,279 recurrences, including 1,834 distant, and 1,559 breast cancer-related deaths over 10 years, resulting in 7,744 lost years of life and $632 million in additional spending, including $549 million in direct medical costs. Projection to 10 years of incident cohorts would lead to approximately 23,000 recurrences, 16,000 deaths, 77,000 lost years of life and $6 billion in direct medical costs. Conclusions: Patients with HER2+ ESBC who do not achieve pCR after neoadjuvant therapy are at ongoing risk of recurrence despite the effectiveness of treatment with T-DM1. There is substantial clinical and economic value in further reducing the recurrence risk among this population. Findings for 2021 Cohort Projected over 10 YearsWith recurrenceNo recurrenceDifferenceLocal/regional recurrences4450445Distant recurrence1,83401,834Breast cancer deaths1,55901,559Non-breast cancer deaths416457-41Direct costs$573M$24M$549MIndirect costs$86M$3.6M$82MLife years90,24997,993-7,744Costs$659M$27M$632M Citation Format: David L Veenstra, Nathaniel Hendrix, Chantal M Dolan, Kathryn Fisher, Deepa Lalla, Nina Hill, Beverly Moy. Population effectiveness model of the consequences of recurrence after trastuzumab emtansine (T-DM1) treatment among U.S. patients with high-risk HER2+ early-stage breast cancer (ESBC) [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-16-01.

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Cohen, Adam L., and John H. Ward. "Risk Reduction Strategies for Ductal Carcinoma In Situ." Journal of the National Comprehensive Cancer Network 8, no. 10 (October 2010): 1211–17. http://dx.doi.org/10.6004/jnccn.2010.0088.

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Ductal carcinoma in situ (DCIS) is a premalignant condition that, if left untreated, may progress to invasive breast cancer. After lumpectomy, DCIS can recur, and about half of recurrences are invasive. In 4 randomized trials, radiation has been shown to decrease the local recurrence rate by about half, though it does not change survival. Based on the results of 3 randomized trials, tamoxifen probably decreases cancer recurrence by about 30%, particularly in young women. Low fat diets, weight loss, and physical activity decrease invasive breast cancer recurrence and may be recommended to certain women with DCIS. Prognostic factors include age, extent of DCIS, margin status, grade, and presence of necrosis, although how these affect adjuvant therapy is unclear. Research evaluating other drugs to reduce recurrence risk and on different ways of delivering radiation continues.

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Lippert, HL, O. Lund, S. Blegvad, and HV Larsen. "Independent risk factors for cumulative recurrence rate after first spontaneous pneumothorax." European Respiratory Journal 4, no. 3 (March 1, 1991): 324–31. http://dx.doi.org/10.1183/09031936.93.04030324.

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From 1975 until 1987, 122 patients without (Group I, mean age 34 yrs) and 20 with pre-existing lung disease (Group II, mean age 66 yrs) were treated for their first spontaneous pneumothorax. Mean follow-up was 5.2 yrs (max. 12.8 yrs). There were 32 chest X-ray verified recurrences, 72% occurring during the first 2 yrs. One, 5 and 10 yr cumulative recurrence freedoms +/- standard error in groups I and II combined were 85 +/- 3%, 75 +/- 4% and 69 +/- 5%, respectively. Using Cox regression analysis in groups I and II combined, pulmonary fibrosis, age greater than or equal to 60 yrs, and height/weight ratio were independent predictors of recurrence. Combinations of these risk factors identified four risk strata with 10 yr recurrence freedoms ranging from 83-0%. Independent predictors in group I alone were pulmonary fibrosis, age greater than or equal to 60 yrs, height/weight ratio, and nonsmoking, resulting in four risk strata with 10 yr recurrence freedoms ranging from 98-31%. Recurrences after first-time treated spontaneous pneumothorax showed a distinct time-related pattern and should accordingly be analysed as a time-related event. In both the total patient-population and in the group without pre-existing lung disease, independent predictors of recurrence were identified, which allowed the patients to be substratified into groups with widely different recurrence rates.

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Більше джерел

Дисертації з теми "Risk of recurrence"

Deng, Lucy. "Seizures following vaccination: risk, outcome and recurrence." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27195.

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Background An adverse event following immunisation is any untoward medical occurrence that follows immunisation and does not necessarily have a causal relationship with the usage of the vaccine. Seizures, ranging from the common and mostly benign febrile seizure to the life-threatening status epilepticus, that occur following immunisation are considered adverse events following immunisation. Febrile seizures have been observed to occur in defined periods following vaccination when a fever is most likely to occur. The magnitude of risk attributed to specific vaccines varies, with no known increased risk seen for some vaccines. Status epilepticus, continuous seizure activity for 5 minutes or more without return of consciousness, or recurrent seizure activity without a return to baseline consciousness in between, has also been reported following vaccination, though the magnitude of attributable risk is unclear. Both seizure types are rare, but serious adverse events, that can follow and sometimes be triggered by immunisation. Because of the potential risk of neurodevelopmental sequalae, seizures can affect both provider and consumer confidence in vaccine safety and therefore immunisation coverage. Knowledge gaps on seizures following vaccination include their clinical severity, developmental outcomes, genetic risks and revaccination outcomes. In my thesis, I aimed to address these gaps to better inform immunisation providers about the risks and outcomes of these potentially serious adverse events following immunisation, to improve guidance on their assessment and management, and ultimately to improve parent and consumer confidence in vaccine safety. Febrile seizures following vaccination In this thesis, I set out to assess the clinical severity, neurodevelopmental outcome and genetic risk of febrile seizures following vaccination, to supplement the known attributable risk of febrile seizures following specific vaccines. Vaccine proximate seizures were defined as VPS was defined as a seizure within 14 days of a vaccination encounter, based on previous studies on the timing of fever and febrile seizures following specific vaccines. I examined the clinical severity of vaccine-proximate febrile seizures through a multi-site prospective cohort study. I discovered that febrile seizures most commonly occurred following the first dose of measles-containing vaccine, and were not clinically any different to febrile seizures due to another cause such as a viral illness. The only factor that prolonged hospitalisation in children with a vaccine-proximate febrile seizure was the presence of concomitant laboratory-confirmed infection. A subsequent prospective case-control study was conducted to assess developmental and behavioural outcomes, and to identify the presence of genetic variants in children with vaccine-proximate febrile seizures compared to children with non-vaccine-proximate febrile seizures and no history of seizures. Using standardised developmental tests administered by certified assessors blinded to the child’s medical history and standardised parent-completed questionnaires, this study found no increased risk of developmental or behavioural problems in children with vaccineproximate febrile seizures compared to children with non-vaccine-proximate seizures or no history of seizures. Genetic variants in the sodium channel gene, SCN1A, associated with a severe form of epilepsy were only identified in children with prolonged vaccine-proximate febrile seizures. Status epilepticus following vaccination Prior to this thesis, there were only case reports and case series on vaccine-proximate status epilepticus, presenting an incomplete and potentially biased picture of the risk and severity of vaccineproximate status epilepticus that may not be generalisable to the whole population. Using a retrospective, population-based, record-linked cohort linking birth, immunisation, hospitalisation and death data, I was able to determine that less than 4% of first episode status epilepticus in children was vaccine proximate. Similar to vaccine-proximate febrile seizures, status epilepticus was found to occur most commonly following the first dose of measles-containing vaccine, but at a rate 35 times lower than that of vaccine-proximate febrile seizure for the same risk window. There was no difference in clinical severity, measured by duration of hospitalisation, intensive care unit admission or death, between vaccine-proximate and non-vaccine-proximate status epilepticus cases. The predictor for ongoing seizures subsequent to the first status epilepticus was seizure onset prior to the status epilepticus episode. Importantly, vaccination uptake decreased following status epilepticus, regardless of the proximity of the status epilepticus episode to vaccination. These findings were confirmed in a second retrospective cohort study I conducted using medical record review to validate the findings from the larger population-based retrospective study that relied on hospital administrative data. The retrospective cohort study also found morbidity following vaccine-proximate status epilepticus was associated with the presence of an underlying genetic epilepsy, where the seizures are the result of a known or presumed genetic defect. Revaccination outcomes following vaccine-proximate seizures Following the identification of the risk and outcome of seizures following vaccination, the next logical clinical question to address was can these children safely proceed with subsequent vaccinations and, if so, how? I, therefore, examined the risk of seizure recurrence following revaccination in children with a previous vaccine-proximate seizure. Through a 5-year multi-site retrospective cohort study, I reviewed the clinical management and outcomes of children with a history of vaccine-proximate seizures who presented to a Specialist Immunisation Clinic, a specialist clinic at tertiary paediatric hospitals where children with a vaccine proximate seizure are provided specialised medical assessment and management for subsequent vaccinations. Vaccine-proximate seizure recurrence was found to be more likely in children with an underlying genetic epilepsy, in particular Dravet syndrome. Reassuringly, the risk of seizure recurrence decreased with the use of prophylactic benzodiazepine with vaccination in these children. Conclusions Vaccination is one of the most effective public health measures for reducing the burden of infectious diseases. However, the success of vaccination programs has been threatened by vaccine hesitancy, that is, the reluctance or refusal to vaccinate despite vaccine availability. Concerns regarding the safety of vaccines and their potential long-term neurological sequalae are amongst the complex reasons why people choose not to vaccinate. My doctoral research has contributed to vaccine safety knowledge globally, specifically in the understanding of seizures, specifically febrile seizures and status epilepticus, as severe acute neurological events following vaccination. In this thesis, I not only identified the children most at risk of neurological sequelae following a vaccine-proximate seizure, but also a revaccination management plan that would allow these children to continue vaccinations without placing them at risk of further vaccine-proximate seizures. These are children aged <12 months, whose underlying genetic epileptic encephalopathy is unmasked by a vaccination event. These children typically present with status epilepticus following vaccination, and are most likely to have further seizures with revaccination if it is given without additional precautions in the form of prophylactic benzodiazepine. My thesis finding highlights the importance of, and future work required to better understand, adversomics – the immunogenetics and immunogenomics of vaccine adverse events at the individual and population level, respectively – and its implications on vaccine safety, confidence and uptake. Finally, my thesis incorporates a variety of research methods, from retrospective record-linked cohort studies to examine whole-of-population risk, retrospective multi-site clinic-based cohort studies to examine detailed clinical management and outcomes, and prospective case-control studies to test hypotheses. I have demonstrated the unique contribution of each of these research methods and the strength in combining these to form a broader pharmacovigilance program of research that can help inform both risk and outcome at a population and individual level. By applying the doctoral research skills I have acquired, I aim to continue my work as a vaccine safety clinician researcher in the monitoring and investigation of vaccine safety signals for novel vaccines, including the multiple COVID-19 vaccines currently in early use globally, to ensure the continued safe and effective use of vaccines in the years to come.

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Costa, Paulo Everton Garcia. "Risk factors for hepatocellular carcinoma recurrence after liver transplantation." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11640.

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Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor, with annual worldwide incidence of over one million cases, accounting for at least 500,000 deaths per year. The majority of cases of HCC occur in the setting of liver cirrhosis. Liver transplantation (LT) is a curative treatment modality for HCC. However the recurrence of HCC after LT is the main obstacle to the success of this treatment. The aim of this study was to evaluate the risk factors for recurrence of hepatocellular carcinoma after conducting LT. In this retrospective, descriptive and analytical study, between May 2002 and April 2012, were conducted 664 liver transplantations (LT) at HUWC â UFC, among which 140 LT were performed in patients with HCC. The risk factors of HCC recurrence after liver transplantation were analysed. The variables analyzed were: sex, age, blood type, etiology of cirrhosis, alpha-fetoprotein level, diagnostic imaging, Milan criteria, time from diagnosis of HCC and the realization of LT, time on the waiting list for the LT and pathological tumor characteristics in explant. The tumor was more frequent in men with an average age of 56 years, infected with hepatitis C virus. The rate of HCC recurrence after LT was 8, 57 % and occurred more often in the first two years after transplantation, with the liver graft being the most common site. In conclusion, independent risk factors for carcinoma hepatocellular recurrence after liver transplantation were: time in the LT waiting list above 7,8 months, liver number nodules over 3.5 nodules, tumors exceeding the Milan criteria, level of alphafetoprotein above 1000 ng/ml and presence of micro-vascular invasion.
O carcinoma hepatocelular (CHC) Ã o mais frequente tumor primÃrio maligno do fÃgado, com incidÃncia mundial anual de mais de um milhÃo de casos, sendo responsÃvel por pelo menos 500.000 mortes por ano. Em torno de 90 % a 95 % dos tumores estÃo associados Ã cirrose. O transplante hepÃtico (TH) Ã uma modalidade de tratamento curativo para o CHC. Entretanto, a recorrÃncia do CHC apÃs o TH Ã o principal obstÃculo ao sucesso deste tratamento. O objetivo deste estudo foi avaliar os fatores de risco para recorrÃncia de carcinoma hepatocelular apÃs a realizaÃÃo de TH. Foram realizados 664 transplantes de fÃgado entre maio de 2002 e abril de 2012, no Hospital UniversitÃrio Walter CantÃdio, da Universidade Federal do CearÃ (HUWC â UFC), dos quais 140 casos em pacientes com diagnÃstico de CHC. Foi realizado um estudo analÃtico, descritivo, retrospectivo e longitudinal deste grupo de pacientes, analisando os fatores de risco para a recorrÃncia de CHC apÃs o TH. As variÃveis analisadas foram: sexo, idade, tipo sanguÃneo, etiologia da cirrose, nÃvel de alfa-fetoproteÃna, mÃtodos diagnÃsticos de imagem, critÃrios de MilÃo, tempo entre o diagnÃstico do CHC e a realizaÃÃo do TH, tempo em lista de espera para o TH e caracterÃsticas anatomopatolÃgicas do tumor no explante. O CHC foi mais frequente em homens com idade mÃdia de 56 anos, infectados pelo vÃrus da hepatite C. A taxa de recorrÃncia do carcinoma hepatocelular apÃs o transplante de fÃgado foi de 8,57% e ocorreu mais frequentemente nos dois primeiros anos apÃs o transplante, tendo como local mais comum o enxerto hepÃtico. Concluiu-se que o tempo de permanÃncia em lista de transplante acima de 7,8 meses, a presenÃa de mais de 3,5 nÃdulos no explante, o tumor excedendo os critÃrios de MilÃo, o nÃvel de Alfa-fetoproteÃna acima de 1000 ng/ml e a presenÃa de invasÃo microvascular sÃo fatores de risco independentes para recorrÃncia de carcinoma hepatocelular apÃs a realizaÃÃo do transplante hepÃtico.

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Knut, R. P. "Groin hernia: anatomically determined risk factors for the recurrence." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19674.

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Stewart, Ann Mary. "Investigation of predictors of recurrent venous leg ulcers and validation of a recurrence risk assessment tool." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/133948/1/Ann_Stewart_Thesis_Redacted.pdf.

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Recurring venous leg ulcers are a serious health problem and it is difficult to predict when they are likely to recur. This research discovered new predictors of recurrence and found a checklist developed to assist in identifying the person's level of risk of recurrence, to be accurate more than 70% of the time. Prevention of recurrence is important and knowledge about the likelihood of these ulcers recurring can assist in preventing this from happening. This research has contributed knowledge to a topic which has had little previous research and has provided evidence to be further examined in large studies.

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Liu, Lin, Karen Messer, John A. Baron, David A. Lieberman, Elizabeth T. Jacobs, Amanda J. Cross, Gwen Murphy, Maria Elena Martinez, and Samir Gupta. "A prognostic model for advanced colorectal neoplasia recurrence." SPRINGER, 2016. http://hdl.handle.net/10150/621531.

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Following colonoscopic polypectomy, US Multisociety Task Force (USMSTF) guidelines stratify patients based on risk of subsequent advanced neoplasia (AN) using number, size, and histology of resected polyps, but have only moderate sensitivity and specificity. We hypothesized that a state-of-the-art statistical prediction model might improve identification of patients at high risk of future AN and address these challenges. Data were pooled from seven prospective studies which had follow-up ascertainment of metachronous AN within 3-5 years of baseline polypectomy (combined n = 8,228). Pooled data were randomly split into training (n = 5,483) and validation (n = 2,745) sets. A prognostic model was developed using best practices. Two risk cut-points were identified in the training data which achieved a 10 percentage point improvement in sensitivity and specificity, respectively, over current USMSTF guidelines. Clinical benefit of USMSTF versus model-based risk stratification was then estimated using validation data. The final model included polyp location, prior polyp history, patient age, and number, size and histology of resected polyps. The first risk cut-point improved sensitivity but with loss of specificity. The second risk cut-point improved specificity without loss of sensitivity (specificity 46.2 % model vs. 42.1 % guidelines, p < 0.001; sensitivity 75.8 % model vs. 74.0 % guidelines, p = 0.64). Estimated AUC was 65 % (95 % CI: 62-69 %). This model-based approach allows flexibility in trading sensitivity and specificity, which can optimize colonoscopy over- versus underuse rates. Only modest improvements in prognostic power are possible using currently available clinical data. Research considering additional factors such as adenoma detection rate for risk prediction appears warranted.

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Dalberg, Kristina. "Risk factors for ipsilateral breast tumor recurrence and uncontrolled local disease /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19981016dalb.

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Habel, Laurel A. "Risk of recurrence following ductal carcinoma in situ of the breast /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10931.

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Hu, Xinhai [Verfasser]. "Risk prediction models for biochemical recurrence after radical prostatectomy / Xinhai Hu." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/114842539X/34.

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Froneberg, Eva. "Youth Cohorts and the Risk of Conflict Recurrence: A Global Quantitative Analysis." Thesis, Uppsala universitet, Institutionen för freds- och konfliktforskning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-384563.

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While the role of youth in post-conflict settings has increasingly gained policy attention, systematic academic studies on this topic remain scarce. This research adds to existing literature by the youth bulge theory of conflict onset to a post-conflict setting. It hypothesizes that large youth bulges at the time conflict episodes end increase the feasibility for rebel groups to relaunch their insurgence and are therefore associated with a higher risk of conflict recurrence. A global quantitative analysis revealed a statistically significant positive correlation between youth bulges and conflict recurrence. Three conditional hypotheses which focus on elements of economic, political and social exclusion that are argued to interact with youth bulges to influence the risk of conflict recurrence found no empirical support. However, the combination of findings for Hypothesis 1 and non-findings for Hypotheses 2 may indicate that the underlying cause for the relationship between youth bulges and conflict recurrence may not be based on young people’s individual grievances and motives to join a rebel group. Instead, other factors may be at play which could not be tested within the scope of this study. Despite its shortcomings, this study therefore confirms the necessity of continuing to investigate the relationship between the age distribution of a population and the risk of conflict recurrence.

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West, Emily S. "Risk factors for trichiasis recurrence in a trachoma-endemic area of central Tanzania." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068228.

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Книги з теми "Risk of recurrence"

Veronique, Benk, and Canadian Coordinating Office for Health Technology Assessment., eds. Impact of radiation wait times on risk of local recurrence of breast cancer: Early stage cancer with no chemotherapy. Ottawa: Canadian Coordinating Office for Health Technology Assessment, 2004.

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Paula, Wells, and Halstead Regina, eds. Rectal cancer: Etiology, pathogenesis and treatment. Hauppauge, NY: Nova Science Publishers, 2009.

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Virginia Institute of Marine Science. Recurrent flooding study for Tidewater Virginia: To the Governor and the General Assembly of Virginia. Richmond: Commonwealth or Virginia, 2013.

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Beenstock, Michael. Recurrence Risk in Autism Spectrum Disorders. Nova Science Publishers, Incorporated, 2021.

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Beenstock, Michael. Recurrence Risk in Autism Spectrum Disorders. Nova Science Publishers, Incorporated, 2021.

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Lancee, Wilhelmus Johannes. The influence of mood variation on risk for recurrence of herpes labialis. 1992.

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Predictable and Avoidable: Repairing Economic Dislocation and Preventing the Recurrence of Crisis. Taylor & Francis Group, 2013.

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McKinlay Gardner, R. J., and David J. Amor. Deriving and Using A Risk Figure. Edited by R. J. McKinlay Gardner and David J. Amor. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199329007.003.0004.

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Risk is a central concept in genetic counseling. Risk is the probability that a particular event will happen. Risks may be discussed in terms of recurrence or of occurrence—the probability that an event will happen again, or that it will happen for the first time, respectively. Risk can also be presented as odds: the ratio of two mutually exclusive probabilities. This chapter provides a basic review of risk assessment, with a particular focus on its application to chromosome abnormalities. The concept of penetrance is introduced. The ways in which risk figures may be conveyed to patients in the clinic are discussed.

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Carr, Nicola. Reducing the Risk of Breast Cancer Recurrence: A Natural Approach with a Focus on Stage 3 Breast Cancer. Independently Published, 2022.

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Lung Cancer: Ultimate Guide for Natural Healing to Reduce the Risk of Recurrence and Live a Healthy Life. Independently Published, 2020.

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Частини книг з теми "Risk of recurrence"

Molina, Kristine M., Kristine M. Molina, Heather Honoré Goltz, Marc A. Kowalkouski, Stacey L. Hart, David Latini, J. Rick Turner, et al. "Recurrence Risk Ratio." In Encyclopedia of Behavioral Medicine, 1633. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_719.

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Nahler, Gerhard. "empiric recurrence risk." In Dictionary of Pharmaceutical Medicine, 65. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_480.

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Wessel, Jennifer. "Recurrence Risk Ratio." In Encyclopedia of Behavioral Medicine, 1859. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_719.

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Yeo, Belinda. "Predicting Risk of Disease Recurrence." In Breast Cancer Survivorship, 15–30. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41858-2_2.

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Calle, Juan C. "What Is the Risk of Stone Recurrence?" In Pocket Guide to Kidney Stone Prevention, 3–7. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-11098-1_1.

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Terushkin, Vitaly, and John A. Carucci. "Management of Local Recurrence and In-Transit Metastasis." In High-Risk Cutaneous Squamous Cell Carcinoma, 175–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47081-7_7.

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Alberts, David S., Silvio Aristizabal, Earl A. Surwit, and Sheldon Weiner. "Primary chemotherapy for high-risk recurrence cervix cancer." In Cancer Treatment and Research, 161–83. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2027-2_11.

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Callegaro, Dario, Alessandro Gronchi, Andrea Napolitano, and Bruno Vincenzi. "Predicting the Risk of Recurrence in Retroperitoneal Sarcoma." In Current Treatment of Retroperitoneal Sarcomas, 143–53. Milano: Springer Milan, 2019. http://dx.doi.org/10.1007/978-88-470-3980-3_12.

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Chan, June M., and Erin L. Richman. "Diet and Prostate Cancer Incidence, Recurrence, and Progression Risk." In Drug Management of Prostate Cancer, 363–73. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60327-829-4_32.

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Kit, James Lee Wai, Sajid Malik, Sujith Wijerathne, and Davide Lomanto. "Endo-laparoscopic Repair of Lateral Ventral Hernia." In Mastering Endo-Laparoscopic and Thoracoscopic Surgery, 449–55. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3755-2_63.

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AbstractLateral ventral hernia (LVH) repair is a challenging procedure for surgeons because of the difficult anatomy, the difficult location, the little knowledge on treatment as compared to midline defects, and the scarcity of cases and experience. Till now the poor outcomes including the potential risks of postoperative pain, infection, and higher risk of recurrence have compromised the success of several approaches [1–5].

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Тези доповідей конференцій з теми "Risk of recurrence"

Shostak, E., R. Liberman, and D. Riker. "Stage I NSCLC: Risk Factors for Recurrence." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1107.

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Krambeck, Amy E., Laureano J. Rangel, Andrew J. LeRoy, David E. Patterson, Matthew T. Gettman, James C. Williams, Andrew P. Evan, James E. Lingeman, and James A. McAteer. "Risk Factors for Stone Recurrence after Percutaneous Nephrolithotomy." In RENAL STONE DISEASE 2: 2nd International Urolithiasis Research Symposium. AIP, 2008. http://dx.doi.org/10.1063/1.2998038.

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Zhang, Lei, Pei He, Chi-Chang Chang, and Wen-Chien Ting. "Grammatical Evolution for Predicting Cervical Cancer Recurrence Risk." In 2023 13th International Conference on Information Technology in Medicine and Education (ITME). IEEE, 2023. http://dx.doi.org/10.1109/itme60234.2023.00173.

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Yasseri, Sirous F., and Jake Prager. "Explosion Recurrence Modelling." In ASME 2004 23rd International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2004. http://dx.doi.org/10.1115/omae2004-51048.

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This paper describes a recurrence law for explosions. The proposed recurrence law fits quite well to the historic explosion data in residential buildings as well as to the data on offshore installations in the North Sea. Generally quantified explosion risk assessment is performed for offshore installations, since it is believed historic data does not correspond to a specific installation and it may not be appropriate for use in performance based explosion engineering, which may in itself require realistic load description of explosion recurrence. The goodness-of-fit of the model for explosion occurrence data obtained using the quantified risk assessment method is also discussed. The paper then introduces the concept of performance-based design, which is an attempt to design structures with predictable performance under explosion loading. Performance objectives such as life safety, collapse prevention, or immediate resumption of operation are used to define the state of an installation following a design explosion. The recurrence law is then used to associate a level of explosion load to each limit state using a desirable level of probability of exceedance during the installations life time.

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Mizumori, Yasuyuki, Nobuya Hirata, Ryota Hiraoka, Katsuya Hirano, Ryota Kominami, Sayaka Takahashi, Yasushi Fukuda, et al. "Preoperative biopsy risk for recurrence?: A retrospective study of risk factors for recurrence of stage 1A non-small cell lung cancer." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa3775.

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Laronde, Denise M., Lewei Zhang, P. Michele Williams, Bertrand Chan, Jay H. Park, Catherine F. Poh, and Miriam P. Rosin. "Abstract 3251: Assessing risk markers for oral cancer recurrence." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3251.

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Hamao, Nobuyoshi, Isao Ito, Naoya Tanabe, Satoshi Konishi, Masahiro Shirata, Issei Oi, Seiichiro Imai, Hisako Matsumoto, and Toyohiro Hirai. "Risk factors for recurrence of fever in aspiration pneumonia." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.2024.

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Hsu, C. M. "Recurrence of Tuberculosis: Incidence Rate and Associated Risk Factors." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2337.

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Vasconcelos, Raissa Naiara Alves Barros, Marcelo Antonini, Samira Marcondes Cabral, Mariana Soares Cardoso, and Matheus de Paula Solino. "RECURRENCE PROFILE AND PROGNOSIS IN A NEGATIVE SENTINEL LYMPH NODE BREAST CANCER PATIENTS COHORT TREATED AT HOSPITAL DO SERVIDOR ESTADUAL DE SÃO PAULO." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1055.

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Introduction: Breast cancer is the main cause of death by cancer among brazilian women and its incidence increases annually. Due to screening e new technologies, diagnosis without axillary metastasis is increasing. Objectives: This study aimed at evaluating locoregional recurrences, distant metastasis, prognostic factors associated to those outcomes and its impact on deaths among breast cancer patients treated in a public hospital of São Paulo. Methods: It is a retrospective cohort study that included 342 T1-3N0 breast cancer patients with negative sentinel lymph node biopsy submitted to primary surgery between March 2014 and March 2019 at Hospital do Servidor Público Estadual (HSPE). Primary outcomes were locoregional recurrence rate, distant metastasis rate, mortality, disease free survival and overall survival. Secondary outcomes were the association between primary outcomes and prognostic factors established in the literature. Results: During 1.5 to 6.4 years of follow-up (median time 3.3 years), there was 3.8% locoregional recurrence cases, 4.1% distant metastasis and 3.8% deaths. Locoregional recurrence free survival in three years was 94.4% and metastasis free survival was 95.6%. Overall survival in three years was 97.2%. It was observed an association between locoregional recurrence histological subtype and hormonal therapy, distant metastasis, histological subtype and tumor grade, deaths and tumor grade. The results evidence that locoregional recurrences increases distant metastasis, but do not reduce overall survival. On the other hand, distant metastasis decreases overall survival. Conclusions: This study showed that breast cancer patients without axillary metastasis treated at HSPE presentedconsistent locoregional recurrence, metastasis and mortality patterns in the literature. Further studies with more participants and longer follow-up are necessary to evaluate the relative risk of each prognostic factor included in the present research.

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Novais, Aurea Maria Lago, Beatriz Santos Rogério, and Renan Carvalho Castello Branco. "Association between risk of obstructive sleep apnea and stroke recurrence: partial results of a cohort." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.614.

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Introduction: Obstructive sleep apnea (OSA) is a disease of upper airways,diagnosed with polisomnography,that is well associated with stroke through diverse mechanisms.Despite that,it still lacks studies about its role in prognosis of stroke,especially in stroke recurrence. Objectives and methods: This study aims to elucidate the possible association between stroke recurrence and risk of OSA.We performed a cohort. Patients were evaluated of risk of OSA with STOP-Bang and SOS scores and remotely evaluated with Rankin, Barthel, questioned about stroke recurrence and another hospitalization during 3.6 and 12 months. We performed univariate analysis (T test,Mann-Whitney or chi-square) and a multivariate analysis with logistic regression (considering P < 0.05). Results: We obtained 190 patients: 7 patients already finished the study and 78 started. 48.9% female, mean age 63.6 ± 6.43 years, mean body mass index 25.69 ± 5.64 kg/m2 , mean SOS 11.65 ± 6.43, mean STOP-Bang 3.22 ± 1.45. Rankin in 3 months mean 2.89 ± 1.81; 6 months mean 2.67 ± 1.89; 12 months mean 5 ± 1.95. Barthel 3 months 62.51 ± 33.44; 6 months 72.40 ± 34.78; 12 months mean 35.40 ± 46.59. 3.7% were hospitalized due to cardiovascular causes; 2.1% due to infection causes and 4.7% due to other causes. 2.6% evolved to death and 1.6% recurred with stroke. Considering STOP-Bang, we had in univariate analysis Rankin 6 months (P = 0.06), Barthel 12 months (P = 0.07) and hospitalization of other causes (P = 0.1). Considering SOS, we obtained stroke recurrence, Rankin 12 months (P = 0.1) and death (P = 0.03). In multivariate analysis, to STOP-Bang, we had Barthel 12 months (P = 0.03); to SOS, it was not possible to perform due to reduced number of stroke recurrence and death. Conclusion: Preliminary results already showed association between OSA and recurrence stroke, which can lead us to a differential approach. Considering the most successful research about this theme obtained 1.2% of recurrence, the study is on the way to elucidate this question.

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Звіти організацій з теми "Risk of recurrence"

Clague, J. J. Recurrence and risk. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1996. http://dx.doi.org/10.4095/213920.

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Bielinskyi, Andrii O., ,. Vladimir N. Soloviev, Viktoria V. Solovieva, Serhiy O. Semerikov, and Michael A. Radin. Recurrence quantification analysis of energy market crises: a nonlinear approach to risk management. Криворізький державний педагогічний університет, 2023. http://dx.doi.org/10.31812/123456789/7733.

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The energy market is characterized by unstable price dynamics, which challenge the quantitative models of pricing processes and result in abnormal shocks and crashes. We use recurrence quantification analysis(RQA) to analyze and construct indicators of intermittent events in energy indices, where regular patterns are interrupted by chaotic fluctuations, which could signal the onset of crisis events. We apply RQA to daily data of Henry Hub natural gas spot prices, WTI spot prices, and Europe Brent spot prices. Our empirical results show that the recurrence measures capture the distinctive features of crashes and can be used for effective risk management strategies.

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Qian, Ao, Xin Zhang, Gang Huo, Jiaojiao Yu, and Xiaoshu Wang. Risk factors of recurrence in Rathke cleft cyst: a systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0070.

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Guo, Zhiyi, Kejia Yang, Jing Lei, Yongjian Zeng, Zhidong Guo, and Fenghua Zhang. Risk factors for recurrence of tic disorders in children：a systematic review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0078.

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Thomson, Scott. Diet and Physical Activity to Prevent Recurrence of High Risk Adenomas: A feasibility study. National Institute for Health and Care Research (NIHR), March 2022. http://dx.doi.org/10.3310/nihropenres.1115185.1.

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Deisseroth, Albert B. Adjuvant Immunotherapy for Patients at High Risk of Recurrence Following Radiation Therapy for Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 2005. http://dx.doi.org/10.21236/ada466640.

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DeCarr, Kimberly. Utility of AV Nodal Characteristics in Identification of Atrioventricular Nodal Reentrant Tachycardia and Risk of Recurrence. University of Tennessee Health Science Center, August 2022. http://dx.doi.org/10.21007/com.lsp.2022.0015.

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Perdigão, Rui A. P., and Julia Hall. Spatiotemporal Causality and Predictability Beyond Recurrence Collapse in Complex Coevolutionary Systems. Meteoceanics, November 2020. http://dx.doi.org/10.46337/201111.

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Causality and Predictability of Complex Systems pose fundamental challenges even under well-defined structural stochastic-dynamic conditions where the laws of motion and system symmetries are known. However, the edifice of complexity can be profoundly transformed by structural-functional coevolution and non-recurrent elusive mechanisms changing the very same invariants of motion that had been taken for granted. This leads to recurrence collapse and memory loss, precluding the ability of traditional stochastic-dynamic and information-theoretic metrics to provide reliable information about the non-recurrent emergence of fundamental new properties absent from the a priori kinematic geometric and statistical features. Unveiling causal mechanisms and eliciting system dynamic predictability under such challenging conditions is not only a fundamental problem in mathematical and statistical physics, but also one of critical importance to dynamic modelling, risk assessment and decision support e.g. regarding non-recurrent critical transitions and extreme events. In order to address these challenges, generalized metrics in non-ergodic information physics are hereby introduced for unveiling elusive dynamics, causality and predictability of complex dynamical systems undergoing far-from-equilibrium structural-functional coevolution. With these methodological developments at hand, hidden dynamic information is hereby brought out and explicitly quantified even beyond post-critical regime collapse, long after statistical information is lost. The added causal insights and operational predictive value are further highlighted by evaluating the new information metrics among statistically independent variables, where traditional techniques therefore find no information links. Notwithstanding the factorability of the distributions associated to the aforementioned independent variables, synergistic and redundant information are found to emerge from microphysical, event-scale codependencies in far-from-equilibrium nonlinear statistical mechanics. The findings are illustrated to shed light onto fundamental causal mechanisms and unveil elusive dynamic predictability of non-recurrent critical transitions and extreme events across multiscale hydro-climatic problems.

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Hubsky, Ashlee. Hepatocellular Carcinoma Recurrence After Liver Transplantation: An Analysis of Risk Factors and Incidence from Oregon Health Science University. Portland State University Library, January 2016. http://dx.doi.org/10.15760/honors.213.

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Zhang, Fangfang, Lili Liu, Tian Li, and Zubing Mei. Prognostic value of metabolic syndrome for risk of stroke recurrence and mortality: A comprehensive systematic review with meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0183.

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