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Статті в журналах з теми "Ruthenium based-photosensitizer"

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Автор: Grafiati

Опубліковано: 14 вересня 2021

Оновлено: 14 лютого 2022

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1

Kap, Zeynep, and Ferdi Karadas. "Visible light-driven water oxidation with a ruthenium sensitizer and a cobalt-based catalyst connected with a polymeric platform." Faraday Discussions 215 (2019): 111–22. http://dx.doi.org/10.1039/c8fd00166a.

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2

Burian, Max, Zois Syrgiannis, Giuseppina La Ganga, Fausto Puntoriero, Mirco Natali, Franco Scandola, Sebastiano Campagna, et al. "Ruthenium based photosensitizer/catalyst supramolecular architectures in light driven water oxidation." Inorganica Chimica Acta 454 (January 2017): 171–75. http://dx.doi.org/10.1016/j.ica.2016.04.010.

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3

Aksakal, Nuray Esra, Hasan Hüseyin Kazan, Esra Tanrıverdi Eçik, and Fatma Yuksel. "A novel photosensitizer based on a ruthenium(ii) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen andin vitrophotodynamic therapy." New Journal of Chemistry 42, no. 21 (2018): 17538–45. http://dx.doi.org/10.1039/c8nj02944j.

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In this study, a novel photosensitizer having two perylenediimide units and a phenanthroline ruthenium(ii) coordination moiety (Ru-BP)has been developed for photodynamic therapy (PDT) of cancer cells.

4

Prompan, Preeyapat, Kittiya Wongkhan, and Rukkiat Jitchati. "Design and Synthesis of Ruthenium (II) Complexes and their Applications in Dye Sensitized Solar Cells (DSSCs)." Advanced Materials Research 770 (September 2013): 92–95. http://dx.doi.org/10.4028/www.scientific.net/amr.770.92.

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Three thiocyanate-free ruthenium (II) sensitizers, [RuII(dcppy)(L1-L3)](PF6)] where dcppy = 4, 4-dicarboxylic acid-2, 2-bipyridine, L1 = 2-(2,4-difluorophenyl)-5-(trifluoromethyl) pyridine, L2 = 2-(2,4-difluorophenyl) pyridine and L3 = 2-phenyl-5-(trifluoromethyl) pyridine were synthesized and applied for dye-sensitized solar cells (DSSCs). The structures of ruthenium complexes were characterized by 1H, 13C NMR and IR spectra. The absorption was studied by UV-Vis spectroscopy and the electrochemical property was determined by cyclic voltammetry. The surface morphology of ruthenium complexes on mica was examined by atomic force microscopy. The performance of this complexes as photosensitizer in TiO2 based dye sensitized solar cells is studied under standard AM 1.5 sunlight and by using an electrolyte.

5

Liu, Jibo, Huijie Shi, Xiaofeng Huang, Qi Shen, and Guohua Zhao. "Efficient Photoelectrochemical Reduction of CO 2 on Pyridyl Covalent Bonded Ruthenium(II) Based-Photosensitizer." Electrochimica Acta 216 (October 2016): 228–38. http://dx.doi.org/10.1016/j.electacta.2016.08.135.

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6

Sahnoun, Riadh, Agalya Govindasamy, and Akira Miyamoto. "Efficiency enhancement of dye-sensitized TiO2solar cell based on ruthenium(II) terpyridyl complex photosensitizer." International Journal of Energy Research 39, no. 7 (February 16, 2015): 977–92. http://dx.doi.org/10.1002/er.3308.

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7

Krawczak, Ewelina. "DYE PHOTOSENSITIZERS AND THEIR INFLUENCE ON DSSC EFFICIENCY: A REVIEW." Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska 9, no. 3 (September 26, 2019): 86–90. http://dx.doi.org/10.35784/iapgos.34.

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Since early 1990s dye-sensitized solar cells (DSSC) has been developed by many research groups all over the World. This paper presents a review of researches focusing on photosensitizer influence on DSSC efficiency. Variety of dye substance has been analyzed. The highest efficiency around 11.2% has been noted for ruthenium-based DSSC devices. Natural dyes allowed to reach 4.6%. The most metal-free organic dyes resulted in efficiency ranged from 5% to 9%, however, some of them (e.g. Y123) allowed to obtain devices with efficiencies equal to 10.3%. Co-sensitization is the new approach which results in efficiencies up to 14.3%.

8

Kumar, Rohan J, Susanne Karlsson, Daniel Streich, Alice Rolandini Jensen, Michael Jäger, Hans-Christian Becker, Jonas Bergquist, Olof Johansson, and Leif Hammarström. "Vectorial Electron Transfer in Donor-Photosensitizer-Acceptor Triads Based on Novel Bis-tridentate Ruthenium Polypyridyl Complexes." Chemistry - A European Journal 16, no. 9 (January 19, 2010): 2830–42. http://dx.doi.org/10.1002/chem.200902716.

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9

Yoo, Je-Ok, Chang-Hee Lee, Byeong-Moon Hwang, Woo Jin Kim, Young-Myeong Kim, and Kwon-Soo Ha. "Regulation of intracellular Ca2+ in the cytotoxic response to photodynamic therapy with a chlorin-based photosensitizer." Journal of Porphyrins and Phthalocyanines 13, no. 07 (July 2009): 811–17. http://dx.doi.org/10.1142/s1088424609001066.

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We investigated regulation of intracellular Ca2+ induced by photodynamic therapy (PDT) with a new chlorin-based photosensitizer, DH-II-24, in human gastric adenocarcinoma cells. DH-II-24-mediated PDT induced necrotic cell death according to post-irradiation time, and produced intracellular reactive oxygen species (ROS) in an irradiation time-dependent manner. PDT also increased intracellular Ca2+ , and this Ca2+ elevation was largely inhibited by BAPTA-AM but not by EGTA. BAPTA-AM inhibited the ROS production by PDT, whereas NAC and Trolox had no effect on the PDT-induced Ca2+ response. In the presence of EGTA, pre-incubation with thapsigargin, Gly-Phe-β-naphthylamide or brefeldin A had no significant effect on the PDT-induced elevation in intracellular Ca2+ . However, ruthenium red affected the initial and late Ca2+ responses to PDT. Thus, DH-II-24-mediated PDT produces intracellular ROS via elevation in intracellular Ca2+ , contributed, at least in part, by mitochondria, which results in necrotic death of the human gastric adenocarcinoma cells.

10

Stathatos, Elias, and Panagiotis Lianos. "Organic/inorganic nanocomposite gels employed as electrolyte supports in Dye-sensitized Photoelectrochemical cells." International Journal of Photoenergy 4, no. 1 (2002): 11–16. http://dx.doi.org/10.1155/s1110662x02000028.

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Dye-sensitized photoelectrochemical cells based onTiO2mesoporous films, a ruthenium bipyridyl derivative as photosensitizer and aSiO2/poly(ethylene glycol)-200 nanocomposite thin film as electrolyte support, have been constructed.TiO2films have been deposited on conductive transparent Indium-Tin Oxide glass slides by means of a sol-gel procedure carried out in reverse-micellar solutions. The photosensitizer has been adsorbed on titania films from ethanolic solutions while the electrolyte layer has been synthesized by a sol-gel procedure. The presence of silica in the nanocomposite electrolyte gel provides the gelifying agent, the compound that holds the cell together in a sandwich form and the sealing agent that protects the cell and secures its long-term function. PEG-200 makes the organic subphase which provides the ionic conductivity. The present work describes the construction of the cell and the study of its efficiency. A variant of the cell has also been made by incorporatingAg+andRu3+ions into titania particles, but these dopants did not improve cell efficiency, either in their oxidized or in their reduced form.

11

Chen, Qihang, Qianqian Zhou, Ting-Ting Li, Runze Liu, Hongwei Li, Fenya Guo, and Yue-Qing Zheng. "Covalent bonding photosensitizer–catalyst dyads of ruthenium-based complexes designed for enhanced visible-light-driven water oxidation performance." Transition Metal Chemistry 44, no. 4 (January 5, 2019): 349–54. http://dx.doi.org/10.1007/s11243-018-00301-3.

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12

Gibson, Andrew J., Robert H. Temperton, Karsten Handrup, Matthew Weston, Louise C. Mayor, and James N. O’Shea. "Charge transfer from an adsorbed ruthenium-based photosensitizer through an ultra-thin aluminium oxide layer and into a metallic substrate." Journal of Chemical Physics 140, no. 23 (June 21, 2014): 234708. http://dx.doi.org/10.1063/1.4882867.

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13

Kaspler, Pavel, Savo Lazic, Sarah Forward, Yaxal Arenas, Arkady Mandel, and Lothar Lilge. "A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy." Photochemical & Photobiological Sciences 15, no. 4 (2016): 481–95. http://dx.doi.org/10.1039/c5pp00450k.

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Mixing the novel Ru²⁺complex TLD1433 with transferrin prior to administration generates a photosensitizing drug with reduced dark toxicity and improved photophysical properties including NIR activation.

14

Nazeeruddin, Md K., S. M. Zakeeruddin, R. Humphry-Baker, T. A. Kaden, and M. Grätzel. "Determination of pKaValues of 4-Phosphonato-2,2‘:6‘,2‘ ‘-Terpyridine and Its Ruthenium(II)-Based Photosensitizer by NMR, Potentiometric, and Spectrophotometric Methods." Inorganic Chemistry 39, no. 20 (October 2000): 4542–47. http://dx.doi.org/10.1021/ic000215+.

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15

Mozer, A. J., Y. Wada, K. J. Jiang, N. Masaki, S. Yanagida, and S. N. Mori. "Efficient dye-sensitized solar cells based on a 2-thiophen-2-yl-vinyl-conjugated ruthenium photosensitizer and a conjugated polymer hole conductor." Applied Physics Letters 89, no. 4 (July 24, 2006): 043509. http://dx.doi.org/10.1063/1.2240296.

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16

LAINE, P., S. CAMPAGNA, and F. LOISEAU. "Conformationally gated photoinduced processes within photosensitizer–acceptor dyads based on ruthenium(II) and osmium(II) polypyridyl complexes with an appended pyridinium group." Coordination Chemistry Reviews 252, no. 23-24 (December 2008): 2552–71. http://dx.doi.org/10.1016/j.ccr.2008.05.007.

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17

Sakamoto, Gentaro, Hiroyasu Tabe, and Yusuke Yamada. "Immobilization of Ir(OH)3 Nanoparticles in Mesospaces of Al-SiO2 Nanoparticles Assembly to Enhance Stability for Photocatalytic Water Oxidation." Catalysts 10, no. 9 (September 3, 2020): 1015. http://dx.doi.org/10.3390/catal10091015.

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Iridium hydroxide (Ir(OH)3) nanoparticles exhibiting high catalytic activity for water oxidation were immobilized inside mesospaces of a silica-nanoparticles assembly (SiO2NPA) to suppress catalytic deactivation due to agglomeration. The Ir(OH)3 nanoparticles immobilized in SiO2NPA (Ir(OH)3/SiO2NPA) catalyzed water oxidation by visible light irradiation of a solution containing persulfate ion (S2O82−) and tris(2,2′-bipyridine)ruthenium(II) ion ([RuII(bpy)3]2+) as a sacrificial electron acceptor and a photosensitizer, respectively. The yield of oxygen (O2) based on the used amount of S2O82− was maintained over 80% for four repetitive runs using Ir(OH)3/SiO2NPA prepared by the co-accumulation method, although the yield decreased for the reaction system using Ir(OH)3/SiO2NPA prepared by the equilibrium adsorption method or Ir(OH)3 nanoparticles without SiO2NPA support under the same reaction conditions. Immobilization of Ir(OH)3 nanoparticles in Al3+-doped SiO2NPA (Al-SiO2NPA) results in further enhancement of the catalytic stability with the yield of more than 95% at the fourth run of the repetitive experiments.

18

Barpuzary, Dipankar, Avishek Banik, Aditya Narayan Panda, and Mohammad Qureshi. "Mimicking the Heteroleptic Dyes for an Efficient 1D-ZnO Based Dye-Sensitized Solar Cell Using the Homoleptic Ruthenium(II) Dipyridophenazine Complex as a Photosensitizer." Journal of Physical Chemistry C 119, no. 8 (February 17, 2015): 3892–902. http://dx.doi.org/10.1021/jp510422d.

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19

Chamberlain, Sarah, Houston D. Cole, John Roque, David Bellnier, Sherri A. McFarland, and Gal Shafirstein. "TLD1433-Mediated Photodynamic Therapy with an Optical Surface Applicator in the Treatment of Lung Cancer Cells In Vitro." Pharmaceuticals 13, no. 7 (June 28, 2020): 137. http://dx.doi.org/10.3390/ph13070137.

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Intra-operative photodynamic therapy (IO-PDT) in combination with surgery for the treatment of non-small cell lung cancer and malignant pleural mesothelioma has shown promise in improving overall survival in patients. Here, we developed a PDT platform consisting of a ruthenium-based photosensitizer (TLD1433) activated by an optical surface applicator (OSA) for the management of residual disease. Human lung adenocarcinoma (A549) cell viability was assessed after treatment with TLD1433-mediated PDT illuminated with either 532- or 630-nm light with a micro-lens laser fiber. This TLD1433-mediated PDT induced an EC50 of 1.98 μM (J/cm2) and 4807 μM (J/cm2) for green and red light, respectively. Cells were then treated with 10 µM TLD1433 in a 96-well plate with the OSA using two 2-cm radial diffusers, each transmitted 532 nm light at 50 mW/cm for 278 s. Monte Carlo simulations of the surface light propagation from the OSA computed light fluence (J/cm2) and irradiance (mW/cm2) distribution. In regions where 100% loss in cell viability was measured, the simulations suggest that >20 J/cm2 of 532 nm was delivered. Our studies indicate that TLD1433-mediated PDT with the OSA and light simulations have the potential to become a platform for treatment planning for IO-PDT.

20

Chen, Quanchi, Vadde Ramu, Yasmin Aydar, Arwin Groenewoud, Xue-Quan Zhou, Martine J. Jager, Houston Cole, et al. "TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models." Cancers 12, no. 3 (March 4, 2020): 587. http://dx.doi.org/10.3390/cancers12030587.

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The ruthenium-based photosensitizer (PS) TLD1433 has completed a phase I clinical trial for photodynamic therapy (PDT) treatment of bladder cancer. Here, we investigated a possible repurposing of this drug for treatment of conjunctival melanoma (CM). CM is a rare but often deadly ocular cancer. The efficacy of TLD1433 was tested on several cell lines from CM (CRMM1, CRMM2 and CM2005), uveal melanoma (OMM1, OMM2.5, MEL270), epidermoid carcinoma (A431) and cutaneous melanoma (A375). Using 15 min green light irradiation (21 mW/cm2, 19 J.cm−2, 520 nm), the highest phototherapeutic index (PI) was reached in CM cells, with cell death occurring via apoptosis and necrosis. The therapeutic potential of TLD1433 was hence further validated in zebrafish ectopic and newly-developed orthotopic CM models. Fluorescent CRMM1 and CRMM2 cells were injected into the circulation of zebrafish (ectopic model) or behind the eye (orthotopic model) and 24 h later, the engrafted embryos were treated with the maximally-tolerated dose of TLD1433. The drug was administrated in three ways, either by (i) incubating the fish in drug-containing water (WA), or (ii) injecting the drug intravenously into the fish (IV), or (iii) injecting the drug retro-orbitally (RO) into the fish. Optimally, four consecutive PDT treatments were performed on engrafted embryos using 60 min drug-to-light intervals and 90 min green light irradiation (21 mW/cm2, 114 J.cm−2, 520 nm). This PDT protocol was not toxic to the fish. In the ectopic tumour model, both systemic administration by IV injection and RO injection of TLD1433 significantly inhibited growth of engrafted CRMM1 and CRMM2 cells. However, in the orthotopic model, tumour growth was only attenuated by localized RO injection of TLD1433. These data unequivocally prove that the zebrafish provides a fast vertebrate cancer model that can be used to test the administration regimen, host toxicity and anti-cancer efficacy of PDT drugs against CM. Based on our results, we suggest repurposing of TLD1433 for treatment of incurable CM and further testing in alternative pre-clinical models.

21

Sano, Yohei, Akira Onoda, and Takashi Hayashi. "Photocatalytic hydrogen evolution by a diiron hydrogenase model based on a peptide fragment of cytochrome c556 with an attached diiron carbonyl cluster and an attached ruthenium photosensitizer." Journal of Inorganic Biochemistry 108 (March 2012): 159–62. http://dx.doi.org/10.1016/j.jinorgbio.2011.07.010.

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22

Waki, Minoru, Soichi Shirai, Ken-ichi Yamanaka, Yoshifumi Maegawa, and Shinji Inagaki. "Heterogeneous water oxidation photocatalysis based on periodic mesoporous organosilica immobilizing a tris(2,2′-bipyridine)ruthenium sensitizer." RSC Advances 10, no. 24 (2020): 13960–67. http://dx.doi.org/10.1039/d0ra00895h.

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23

Volpato, Giulia Alice, Martina Marasi, Thomas Gobbato, Francesca Valentini, Federica Sabuzi, Valeria Gagliardi, Alessandro Bonetto, et al. "Photoanodes for water oxidation with visible light based on a pentacyclic quinoid organic dye enabling proton-coupled electron transfer." Chemical Communications 56, no. 15 (2020): 2248–51. http://dx.doi.org/10.1039/c9cc09805d.

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A novel pentacyclic quinoid photosensitizer with extended absorption in the visible region and enabling proton-coupled electron transfer is employed in photoelectrodes for water oxidation in combination with a ruthenium polyoxometalate catalyst.

24

Shylin, Sergii I., Mariia V. Pavliuk, Luca D’Amario, Igor O. Fritsky, and Gustav Berggren. "Photoinduced hole transfer from tris(bipyridine)ruthenium dye to a high-valent iron-based water oxidation catalyst." Faraday Discussions 215 (2019): 162–74. http://dx.doi.org/10.1039/c8fd00167g.

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Fast visible light-driven water oxidation catalyzed by the Fe^IV cage complex relies on its efficient hole scavenging activity in the system utilizing [Ru(bpy)₃]²⁺ as a photosensitizer.

25

Martins, Tássia Joi, Laisa Bonafim Negri, Laena Pernomian, Kelson do Carmo Freitas Faial, Congcong Xue, Regina N. Akhimie, Michael R. Hamblin, Claudia Turro, and Roberto S. da Silva. "The Influence of Some Axial Ligands on Ruthenium–Phthalocyanine Complexes: Chemical, Photochemical, and Photobiological Properties." Frontiers in Molecular Biosciences 7 (January 12, 2021). http://dx.doi.org/10.3389/fmolb.2020.595830.

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This work presents a new procedure to synthesize ruthenium–phthalocyanine complexes and uses diverse spectroscopic techniques to characterize trans-[RuCl(Pc)DMSO] (I) (Pc = phthalocyanine) and trans-[Ru(Pc)(4-ampy)2] (II) (4-ampy = 4-aminopyridine). The triplet excited-state lifetimes of (I) measured by nanosecond transient absorption showed that two processes occurred, one around 15 ns and the other around 3.8 μs. Axial ligands seemed to affect the singlet oxygen quantum yield. Yields of 0.62 and 0.14 were achieved for (I) and (II), respectively. The lower value obtained for (II) probably resulted from secondary reactions of singlet oxygen in the presence of the ruthenium complex. We also investigate how axial ligands in the ruthenium–phthalocyanine complexes affect their photo-bioactivity in B16F10 murine melanoma cells. In the case of (I) at 1 μmol/L, photosensitization with 5.95 J/cm2 provided B16F10 cell viability of 6%, showing that (I) was more active than (II) at the same concentration. Furthermore, (II) was detected intracellularly in B16F10 cell extracts. The behavior of the evaluated ruthenium–phthalocyanine complexes point to the potential use of (I) as a metal-based drug in clinical therapy. Changes in axial ligands can modulate the photosensitizer activity of the ruthenium phthalocyanine complexes.

26

Oger, Samuel, Hajar Baguia, Tuan-Anh Phan, Titouan Teunens, Jérôme Beaudelot, Cécile Moucheron, and Gwilherm Evano. "[Cu(bcp)DPEPhos]+: a Versatile and Efficient Copper-Based Photoredox Catalyst and Photosensitizer." SynOpen, May 10, 2021. http://dx.doi.org/10.1055/a-1504-6972.

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The development of photoredox catalysis has recently enabled the design of remarkably powerful synthetic tools now commonly used in a wide array of chemical transformations, and notably for the generation of radical species under mild, safe and environmentally friendly conditions. This field is largely dominated by ruthenium and iridium complexes, the main alternative to the use of these photocatalysts mostly relying on the use of organic dyes, which poses problems not only in terms of cost - therefore strongly limiting synthetic applications of photocatalysis - but also, more importantly, for the design of new light-mediated transformations. Much less attention has been devoted to the use of copper complexes in photoredox catalysis, despite their strong potential not only as cheaper catalysts but also for the activation of a broader range of substrates. Most copper complexes are indeed known to be poor photocatalysts, mostly due to their short-lived excited states and low redox potentials. Over the last decade, one copper-based copper complex has however emerged as a remarkably efficient and general photoredox catalyst, which is at the core of this Spotlight that highlights its applications as a photosensitizer and its potential.

27

AYAZ, Furkan. "Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro." Cumhuriyet Science Journal, December 24, 2018. http://dx.doi.org/10.17776/csj.453074.

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28

Munegowda, Manjunatha Akathatti, Carl Fisher, Daniel Molehuis, Warren Foltz, Mark Roufaiel, Jay Bassan, Mark Nitz, Arkady Mandel, and Lothar Lilge. "Efficacy of ruthenium coordination complex–based Rutherrin in a preclinical rat glioblastoma model." Neuro-Oncology Advances 1, no. 1 (May 1, 2019). http://dx.doi.org/10.1093/noajnl/vdz006.

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Abstract Background Glioblastoma is an aggressive brain cancer in adults with a grave prognosis, aggressive radio and chemotherapy provide only a 15 months median survival. Methods We evaluated the tolerability and efficacy of the Ruthenium-based photosensitizer TLD-1433 with apo-Transferrin (Rutherrin) in the rat glioma 2 (RG-2) model. The specific tumor uptake ratio and photodynamic therapy (PDT) threshold of the rat glioblastoma and normal brain were determined, survival and CD8+T-cell infiltration post-therapy were analyzed. Results were compared with those obtained for 5-aminolevulinic acid (ALA)-induced Protoporphyrin IX (PpIX)-mediated photodynamic therapy in the same animal model. As both photosensitizers have different photophysical properties, the number of absorbed photons required to achieve an equal cell kill was determined for in vitro and in vivo studies. Results A significantly lower absorbed energy was sufficient to achieve LD50 with Rutherrin versus PpIX-mediated PDT. Rutherrin provides a higher specific uptake ratio (SUR) >20 in tumors versus normal brain, whereas the SUR for ALA-induced PpIX was 10.6. To evaluate the short-term tissue response in vivo, enhanced T2-weighted magnetic resonance imaging (MRI) provided the spatial extent of edema, post PpIX-PDT at twice the cross-section versus Rutherrin-PDT suggesting reduced nonspecific damage, typically associated with a secondary wave of neuronal damage. Following a single therapy, a significant survival increase was observed in rats bearing glioma for PDT mediated by Rutherrin versus PpIX for the selected treatment conditions. Rutherrin-PDT also demonstrated an increased CD8+T-cell infiltration in the tumors. Conclusion Rutherrin-PDT was well tolerated providing a safe and effective treatment of RG-2 glioma.