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Статті в журналах з теми "Sam Newman"
1
Olszanowski, Piotr. "Poszukiwanie prawdy moralnej w życiu i twórczości Johna Henry’ego Newmana." Teologia i Moralność 13, no. 2(24) (March 22, 2019): 169–82. http://dx.doi.org/10.14746/tim.2018.24.2.9.
Повний текст джерелаАнотація:
Prawda zajmuje w życiu człowieka istotne miejsce, a sam człowiek wezwany jest ku temu, aby odkryć jej pełnie. Pytania dotyczące prawdy i jej natury pojawiały się już w starożytności i nurtowały umysły najwybitniejszych filozofów, a później z całą konsekwencją wędrowały poprzez przestrzenie wieków aż ku nowożytności. Kwestia prawdy obecna jest w żywy sposób także w nauczaniu Kościoła.Obecny zakres debaty dotyczący pojęcia prawdy w jej znaczeniu obiektywnym może być różnie formułowany. W zróżnicowanej oraz wieloaspektowej strukturze człowiek, aby odnaleźć swoją tożsamość i przebić się przez degradację pojęciową, potrzebuje jasnych znaków, które ukażą mu właściwy kierunek postępowania i odczytywania rzeczywistości w jej najgłębszym wymiarze. W tym znaczeniu prawda jawi się jako warunek sine qua non w odniesieniu do ludzi, pragnących prowadzić swoje życie zgodnie z wymaganiami zapisanymi na kartach Ewangelii.Poniższy artykuł podejmuję próbę przybliżenia rzeczywistości prawdy w jej ujęciu moralnym w oparciu o życie i twórczość wybitnego teologa, jakim był John Henry Newman. To postać, którą należy rozpatrywać jako jednego z najwybitniejszych myślicieli XIX wieku, wyjątkowego pisarza oraz wielkiego intelektualisty. Życie tego znamienitego człowiek przepełnione było umiłowaniem prawdy, co wielu badaczy zamyka w kategorii pasji, podkreślając szczególnego rodzaju dyspozycję ukierunkowaną ku prawdzie. Temu, kto sięga po jego dzieła oraz spogląda na jego twórczość daje się poznać jako gorliwy uczeń prawdy, który kochał ją ponad wszystko inne. Fascynująca historia wiary i odwagi angielskiego konwertyty, stała się wyznacznikiem wszelkich podejmowanych przez niego decyzji, a on sam do dziś stanowi inspirację dla wszystkich, którzy pragną kształtować swoje życie w oparciu o fundament, jakim jest Prawda.
2
Zakir, Zahid. "Physically consistent metrics with independent parameters instead of standard metrics with unphysical consequences. 2. Rotating sources." QUANTUM AND GRAVITATIONAL PHYSICS 3 (January 24, 2022): 1–16. http://dx.doi.org/10.9751/qgph.3-017.7694.
Повний текст джерелаАнотація:
The Kerr metric, the external metric for a rotating body, contains the equatorial gravitational radius implicitly depending on the specific angular momentum (SAM). Ignoring this dependence due to the formal mathematical approach without understanding the physical aspects led to absurd unphysical consequences in the black hole theory, in particular, that an increase in the rotational energy at increasing SAM weakens gravity, decreasing the gravitational radius at the pole and the effects of gravity (redshifts, mean radii of orbits and shadows). This shortcoming of the Kerr metric is improved in a new form of this metric with an independent parameter - the gravitational radius at the pole, determined by the mass of matter without rotational energy. The contributions of the energies of matter and rotation have the same sign and an increase in SAM strengthens gravity, increasing its effects (the equatorial gravitational radius, redshifts, mean radii of orbits and shadows). The modified form of the Kerr metric describes the gravitational field of a frozar having angular momentum, a star with frozen structure and the surface asymptotically tending to the local gravitational radius (minimal at pole and maximal at equator). The application of this method to the Kerr-Newman metric, including the charge, and to the NUT metric, gave modified forms of these metrics with independent parameters. In the frozar theory, particle energies are positive everywhere, and the theory is free from the non-physical effects of the former black hole theory (horizons, singularities, ergosphere and the extraction of energy from it, evaporation). Thermodynamics of frozars follows from the almost irreversible freezing, as the result of which, during accretion and other processes, the mass of neutral matter without rotational energy grows almost irreversibly.
3
Zakir, Zahid. "Physically consistent metrics with independent parameters instead of standard metrics with unphysical consequences. 2. Rotating sources." QUANTUM AND GRAVITATIONAL PHYSICS 3 (January 24, 2022): 1–16. http://dx.doi.org/10.9751/qgph.2-016.7694.
Повний текст джерелаАнотація:
The Kerr metric, the external metric for a rotating body, contains the equatorial gravitational radius implicitly depending on the specific angular momentum (SAM). Ignoring this dependence due to the formal mathematical approach without understanding the physical aspects led to absurd unphysical consequences in the black hole theory, in particular, that an increase in the rotational energy at increasing SAM weakens gravity, decreasing the gravitational radius at the pole and the effects of gravity (redshifts, mean radii of orbits and shadows). This shortcoming of the Kerr metric is improved in a new form of this metric with an independent parameter - the gravitational radius at the pole, determined by the mass of matter without rotational energy. The contributions of the energies of matter and rotation have the same sign and an increase in SAM strengthens gravity, increasing its effects (the equatorial gravitational radius, redshifts, mean radii of orbits and shadows). The modified form of the Kerr metric describes the gravitational field of a frozar having angular momentum, a star with frozen structure and the surface asymptotically tending to the local gravitational radius (minimal at pole and maximal at equator). The application of this method to the Kerr-Newman metric, including the charge, and to the NUT metric, gave modified forms of these metrics with independent parameters. In the frozar theory, particle energies are positive everywhere, and the theory is free from the non-physical effects of the former black hole theory (horizons, singularities, ergosphere and the extraction of energy from it, evaporation). Thermodynamics of frozars follows from the almost irreversible freezing, as the result of which, during accretion and other processes, the mass of neutral matter without rotational energy grows almost irreversibly.
4
Schäfer, Daniel, Thiên-Trí Lâm, Tobias Geiger, Markus Mainiero, Susanne Engelmann, Muzaffar Hussain, Armin Bosserhoff, et al. "A Point Mutation in the Sensor Histidine Kinase SaeS of Staphylococcus aureus Strain Newman Alters the Response to Biocide Exposure." Journal of Bacteriology 191, no. 23 (September 25, 2009): 7306–14. http://dx.doi.org/10.1128/jb.00630-09.
Повний текст джерелаАнотація:
ABSTRACT Staphylococcus aureus reacts to changing environmental conditions such as heat, pH, and chemicals through global regulators such as the sae (S. aureus exoprotein expression) two-component signaling system. Subinhibitory concentrations of some antibiotics were shown to increase virulence factor expression. Here, we investigated the S. aureus stress response to sublethal concentrations of a commonly used biocide (Perform), by real-time quantitative PCR (qRT-PCR), promoter activity assay, sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, and a flow cytometric invasion assay. Perform, acting through the production of reactive oxygen species, generally downregulated expression of extracellular proteins in strains 6850, COL, ISP479C but upregulated these proteins in strain Newman. Upregulated proteins were sae dependent. The Perform component SDS, but not paraquat (another oxygen donor), mimicked the biocide effect. Eap (extracellular adherence protein) was most prominently augmented. Upregulation of eap and sae was confirmed by qRT-PCR. Promoter activity of sae P1 was increased by Perform and SDS. Both substances enhanced cellular invasiveness, by 2.5-fold and 3.2-fold, respectively. Increased invasiveness was dependent on Eap and the sae system, whereas agr, sarA, sigB, and fibronectin-binding proteins had no major effect in strain Newman. This unique response pattern was due to a point mutation in SaeS (the sensor histidine kinase), as demonstrated by allele swapping. Newman saePQRS ISP479C behaved like ISP479C, whereas saePQRS Newman rendered ISP479C equally responsive as Newman. Taken together, the findings indicate that a point mutation in SaeS of strain Newman was responsible for increased expression of Eap upon exposure to sublethal Perform and SDS concentrations, leading to increased Eap-dependent cellular invasiveness. This may be important for understanding the regulation of virulence in S. aureus.
5
Alvarez, Lucía P., María S. Barbagelata, Mariana Gordiola, Ambrose L. Cheung, Daniel O. Sordelli, and Fernanda R. Buzzola. "Salicylic Acid Diminishes Staphylococcus aureus Capsular Polysaccharide Type 5 Expression." Infection and Immunity 78, no. 3 (December 14, 2009): 1339–44. http://dx.doi.org/10.1128/iai.00245-09.
Повний текст джерелаАнотація:
ABSTRACT Capsular polysaccharides (CP) of serotypes 5 (CP5) and 8 (CP8) are major Staphylococcus aureus virulence factors. Previous studies have shown that salicylic acid (SAL), the main aspirin metabolite, affects the expression of certain bacterial virulence factors. In the present study, we found that S. aureus strain Reynolds (CP5) cultured with SAL was internalized by MAC-T cells in larger numbers than strain Reynolds organisms not exposed to SAL. Furthermore, the internalization of the isogenic nonencapsulated Reynolds strain into MAC-T cells was not significantly affected by preexposure to SAL. Pretreatment of S. aureus strain Newman with SAL also enhanced internalization into MAC-T cells compared with that of untreated control strains. Using strain Newman organisms, we evaluated the activity of the major cap5 promoter, which was significantly decreased upon preexposure to SAL. Diminished transcription of mgrA and upregulation of the saeRS transcript, both global regulators of CP expression, were found in S. aureus cultured in the presence of SAL, as ascertained by real-time PCR analysis. In addition, CP5 production by S. aureus Newman was also decreased by treatment with SAL. Collectively, our data demonstrate that exposure of encapsulated S. aureus strains to low concentrations of SAL reduced CP production, thus unmasking surface adhesins and leading to an increased capacity of staphylococci to invade epithelial cells. The high capacity of internalization of the encapsulated S. aureus strains induced by SAL pretreatment may contribute to the persistence of bacteria in certain hosts.
6
Macnaughton, W. R. "John Updike by Judie Newman." Studies in American Fiction 17, no. 1 (1989): 124–25. http://dx.doi.org/10.1353/saf.1989.0000.
Повний текст джерела
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Venkatasubramaniam, Arundhathi, Tulasikumari Kanipakala, Nader Ganjbaksh, Rana Mehr, Ipsita Mukherjee, Subramaniam Krishnan, Taeok Bae, M. Aman, and Rajan Adhikari. "A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System." Toxins 10, no. 9 (September 18, 2018): 377. http://dx.doi.org/10.3390/toxins10090377.
Повний текст джерелаАнотація:
Cytolytic pore-forming toxins including alpha hemolysin (Hla) and bicomponent leukotoxins play an important role in the pathogenesis of Staphylococcus aureus. These toxins kill the polymorphonuclear phagocytes (PMNs), disrupt epithelial and endothelial barriers, and lyse erythrocytes to provide iron for bacterial growth. The expression of these toxins is regulated by the two-component sensing systems Sae and Agr. Here, we report that a point mutation (L18P) in SaeS, the histidine kinase sensor of the Sae system, renders the S. aureus Newman hemolytic activity fully independent of Hla and drastically increases the PMN lytic activity. Furthermore, this Hla-independent activity, unlike Hla itself, can lyse human erythrocytes. The Hla-independent activity towards human erythrocytes was also evident in USA300, however, under strict agr control. Gene knockout studies revealed that this Hla-independent Sae-regulated activity was entirely dependent on gamma hemolysin A subunit (HlgA). In contrast, hemolytic activity of Newman towards human erythrocytes from HlgAB resistant donors was completely dependent on agr. The culture supernatant from Newman S. aureus could be neutralized by antisera against two vaccine candidates based on LukS and LukF subunits of Panton-Valentine leukocidin but not by an anti-Hla neutralizing antibody. These findings display the complex involvement of Sae and Agr systems in regulating the virulence of S. aureus and have important implications for vaccine and immunotherapeutics development for S. aureus disease in humans.
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Mainiero, Markus, Christiane Goerke, Tobias Geiger, Christoph Gonser, Silvia Herbert, and Christiane Wolz. "Differential Target Gene Activation by the Staphylococcus aureus Two-Component System saeRS." Journal of Bacteriology 192, no. 3 (November 20, 2009): 613–23. http://dx.doi.org/10.1128/jb.01242-09.
Повний текст джерелаАнотація:
ABSTRACT The saePQRS system of Staphylococcus aureus controls the expression of major virulence factors and encodes a histidine kinase (SaeS), a response regulator (SaeR), a membrane protein (SaeQ), and a lipoprotein (SaeP). The widely used strain Newman is characterized by a single amino acid change in the sensory domain of SaeS (Pro18 in strain Newman [SaeSP], compared with Leu18 in other strains [SaeSL]). SaeSP determines activation of the class I sae target genes (coa, fnbA, eap, sib, efb, fib, sae), which are highly expressed in strain Newman. In contrast, class II target genes (hla, hlb, cap) are not sensitive to the SaeS polymorphism. The SaeSL allele (saeSL ) is dominant over the SaeSP allele, as shown by single-copy integration of saePQRSL in strain Newman, which results in severe repression of class I target genes. The differential effect on target gene expression is explained by different requirements for SaeR phosphorylation. From an analysis of saeS deletion strains and strains with mutated SaeR phosphorylation sites, we concluded that a high level of SaeR phosphorylation is required for activation of class I target genes. However, a low level of SaeR phosphorylation, which can occur independent of SaeS, is sufficient to activate class II target genes. Using inducible saeRS constructs, we showed that the expression of both types of target genes is independent of the saeRS dosage and that the typical growth phase-dependent gene expression pattern is not driven by SaeRS.
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Sanok, Catherine. "Medieval Crossover: Reading the Secular against the Sacred by Barbara Newman." Studies in the Age of Chaucer 36, no. 1 (2014): 328–32. http://dx.doi.org/10.1353/sac.2014.0021.
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Goerke, Christiane, Ursula Fluckiger, Andrea Steinhuber, Vittoria Bisanzio, Martina Ulrich, Markus Bischoff, Joseph M. Patti та Christiane Wolz. "Role of Staphylococcus aureus Global Regulators sae and σB in Virulence Gene Expression during Device-Related Infection". Infection and Immunity 73, № 6 (червень 2005): 3415–21. http://dx.doi.org/10.1128/iai.73.6.3415-3421.2005.
Повний текст джерелаАнотація:
ABSTRACT The ability of Staphylococcus aureus to adapt to different environments is due to a regulatory network comprising several loci. Here we present a detailed study of the interaction between the two global regulators sae and σB of S. aureus and their influence on virulence gene expression in vitro, as well as during device-related infection. The expression of sae, asp23, hla, clfA, coa, and fnbA was determined in strain Newman and its isogenic saeS/R and sigB mutants by Northern analysis and LightCycler reverse transcription-PCR. There was no indication of direct cross talk between the two regulators. sae had a dominant effect on target gene expression during device-related infection. σB seemed to be less active throughout the infection than under induced conditions in vitro.
Дисертації з теми "Sam Newman"
1
Ross, Julian. "The Jekyll and Hyde Element: The Career of Geelong Football Club Champion and Media Celebrity John ‘Sam’ Newman." Thesis, 2017. https://vuir.vu.edu.au/39507/.
Повний текст джерелаАнотація:
Life histories of many famous Australian Rules football figures have been published.
Yet despite John ‘Sam’ Newman having a significant influence as both a player and a
media persona, neither aspects of his career have been the focus of systematic
academic study. This thesis aims to redress the deficiency by deploying biographical
methods to examine both Newman’s football and media careers. The first half of the
thesis explores how a privileged secondary education shaped Newman’s attitude to
life and football, before turning to his football career with the Geelong Football Club.
The second half of the thesis traces Newman’s increasingly controversial media
career in print, radio, and television – most notably on Channel Nine’s The Footy
Show. A key aim of the thesis is to explore how and why the warm and generous
John Newman developed the outlandish, sexist, patronising, opinionated, and
narcissistic, persona of ‘Sam’ Newman that has both attracted and appalled television
audiences for decades. Accordingly, the thesis concludes that Newman is a complex
person, exhibiting two different personalities that sometimes coalesce, thus filling an
intriguing gap in the corpus of studies of the playing and media careers of influential Australian Rules footballers.
2
Makgotlho, Phuti Edward. "Molecular characterization of the staphylococcal two component system sae and its role in the regulation of the adhesin Eap under SDS stress stimulation." Doctoral thesis, 2014. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-149403.
Повний текст джерелаАнотація:
The Staphylococcus aureus two component system (TCS) sae governs expression of numerous virulence factors, including Eap (extracellular adherence protein), which in turn among other functions also mediates invasion of host cells. The sae TCS is encoded by the saePQRS operon, with saeS coding for the sensor histidine kinase (SaeS) and saeR encoding the response regulator (SaeR). The saeRS system is preceded by two additional open reading frames (ORFs), saeP and saeQ, which are predicted to encode a lipoprotein (SaeP) and a membrane protein (SaeQ), respectively. Earlier, we have shown that SDS-containing subinhibitory concentrations of biocides (Perform®) and SDS alone activate sae transcription and increase cellular invasiveness in S. aureus strain Newman. The effect is associated with an amino acid exchange in the N-terminus of SaeS (L18P), specific to strain Newman. In this work, the role of whether the two additional genes, saePQ coding for the accessory proteins SaeP and SaeQ, respectively, are involved in SDS-mediated saeRS was investigated. It could demonstrated that the lack of the SaeP protein resulted in an increased saeRS transcription without SDS stress in both SaeSL/P variants, while the SDS effect was less pronounced on sae and eap expression compared to the Newman wildtype, suggesting that the SaeP protein represses the sae system. Also, SDS-mediated inductions of sae and eap transcription along with enhanced invasion were found to be dependent on presence of the SaeSP variant in Newman wildtype. On the other hand, the study also shows that the saePQ region of the sae operon is required for fully functional two-component system saeRS under normal growth conditions, but it is not involved in SDS-mediated activation of the saeS signaling and sae-target class I gene, eap. In the second approach, the study investigates whether SDS-induced sae expression and host cell invasion is common among S. aureus strains not carrying the (L18P) point mutation. To demonstrate this strain Newman, its isogenic saeS mutants, and various S. aureus isolates were analysed for sae, eap expression and cellular invasiveness. Among the strains tested, SDS exposure resulted only in an increase of sae transcription, Eap production and cellular invasiveness in strain Newman wild type and MRSA strain ST239-635/93R, the latter without an increase in Eap. Interestingly, the epidemic community-associated MRSA strain, USA300 LAC showed a biphasic response in sae transcription at different growth stages, which, however, was not accompanied by increased invasiveness. All other clinical isolates investigated displayed a decrease of the parameters tested. While in strain Newman the SDS effect was due to the saeSP allele, this was not the case in strain ST239-635/93R and the biphasic USA300 strains. Also, increased invasiveness of ST239-635/93R was found to be independent of Eap production. Furthermore, to investigate the global effect of SDS on sae target gene expression, strain Newman wild-type and Newman ∆sae were treated with SDS and analyzed for their transcription profiles of sae target genes using microarray assays. We could show that subinhibitory concentrations of SDS upregulate and downregulate gene expression of several signaling pathways involved in biosynthetic, metabolic pathways as well as virulence, host cell adherence, stress reponse and many hypothetical proteins. In summary, the study sheds light on the role of the upstream region saePQ in SDS-mediated saeRS and eap expression during S. aureus SDS stress. Most importantly, the study also shows that subinhibitory SDS concentrations have pronounced strain-dependent effects on sae transcription and subsequent host cell invasion in S. aureus, with the latter likely to be mediated in some strains by other factors than the known invasin Eap and FnBP proteins. Moreover, there seems to exist more than the saeSP-mediated mechanism for SDS-induced sae transcription in clinical S. aureus isolates. These results help to further understand and clarify virulence and pathogenesis mechanisms and their regulation in S. aureusDas Zwei Komponenten-Systems (TCS) Sae in S. aureus reguliert die Expression einer Vielzahl von Virulenzfaktoren, dazu gehört unter anderem das extrazelluläre Adhärenzprotein Eap, welches neben weiteren Funktionen, die Invasion in eukaryotische Wirtszellen vermittelt. Die Gene des sae TCS sind in einem Operon organisiert (saePQRS), wobei saeS für die sensorische Histidinkinase (SaeS) und saeR für den „Response Regulator“ (SaeR) kodieren. Diesen Genen sind zwei weitere Genabschnitte, saeP und saeQ, vorangestellt, wobei saeP vermutlich für ein Lipoprotein (SaeP) und saeQ für ein Membranprotein (RelQ) kodieren. In einer früheren Arbeit konnten wir zeigen, dass SDS-haltige Biozide (Perform©) unter sub- inhibitorischen Konzentrationen, sowie reines SDS, die sae Transkription aktiviert und dadurch zu einer erhöhten Invasion des S. aureus Stamms Newman in Wirtszellen führt. Dieser Effekt ist assoziiert mit einem spezifischen Aminosäureaustausch im N-terminus von SaeS (L18P) des Stamm Newman. In dieser Arbeit soll nun die Beteiligung der zwei zusätzlichen Gene, saeP und saeQ, an der SDS vermittelten transkriptionellen Induktion von saeR/S untersucht werden. Es konnte gezeigt werden, dass ohne SaeP, die saeR/S Transkription in beiden SaeL/P Varianten erhöht war, wobei eine zusätzliche SDS Behandlung hierfür nicht notwendig war. Im Gegenteil, es zeigte sich, dass der SDS Effekt auf die sae und eap Expression in der saeP Mutante deutlich weniger ausgeprägt ist als im Wildtyp Stamm. Das läßt vermuten, dass das Lipoprotein SaeP repremierend auf das sae System einwirkt. Des Weiteren wurde festgestellt, dass die SDS vermittelte transkriptionelle Induktion von sae und eap, zusammen mit der erhöhten Invasion, abhängig vom vorhanden sein der SaeSP Variante im Newman Wildtyp Stamm ist. Die Arbeit zeigt, dass die saePQ Region wichtig ist für die vollständige Funktion des Zwei Komponenten Systems SaeRS unter normalen Wachstumsbedingungen. Jedoch ist diese Region nicht involviert in der Aktivierung von SaeS, mit SDS als Signalgeber, sowie der darauffolgenden Aktivierung des sae Zielgens eap. In einem zweiten Ansatz wurde untersucht, ob die SDS induzierte sae Expression und Wirtszellinvasion auch häufig in S. aureus Stämmen auftritt, welche keine (L18P) Punktmutation besitzen. Dafür wurde Stamm Newman, die isogene saeS Mutante und verschiedene S. aureus Klinikisolate auf ihre sae, eap Expression, sowie zelluläre Invasionsfähigkeit hin analysiert. Von den getesteten Stämmen reagiert nur Wildtyp Stamm Newman und ein MRSA Stamm ST239-635/93R mit gesteigerter sae Transkription, Eap Produktion und zellulärer Invasion. Der MRSA Stamm jedoch ohne erhöhte Eap Produktion. Interessanterweise zeigt der „community- associated“ MRSA Stamm USA300 LAC eine biphasische sae Transkription in verschiedenen Wachstumsphasen, welche jedoch nicht einhergeht mit erhöhter Invasion. Alle anderen Klinikisolate zeigten abnehmende Tendenzen in den getesteten Parametern. Während im Stamm Newman der SDS Effekt auf das saeSP Allel zurückzuführen ist, gilt dies nicht für den Stamm ST239-635/93R, sowie den biphasischen Stamm USA300. Außerdem konnte gezeigt werden, dass die erhöhte Invasion des Stamms ST239-635/93R unabhängig von seiner Eap Produktion ist. Des Weiteren zeigten wir den globalen Effekt von SDS auf die sae Zielgenexpression. Dafür behandelten wir Wildtyp Stamm Newman mit SDS und analysierten die Transkription der sae Zielgene mittels Microarray Analyse. Wir konnten zeigen, dass subinhibitorische SDS Konzentrationen, induzierende als auch repremierende Auswirkungen auf die Genexpression haben. Dabei sind Gene betroffen, die involviert sind in verschiedene Signalwege, Biosynthese/Metabolismus als auch in Virulenz, Wirtzelladhärenz und Stressantwort. Zusammenfassend gibt die Arbeit Aufschluss über die Rolle der „upstream“ Region saePQ hinsichtlich der SDS-abhängigen saeRS und eap Expression in S. aureus. Am wichtigsten ist hierbei die Erkenntnis, das subinhibitorische SDS Konzentrationen einen deutlichen stammabhängigen Effekt auf die sae Transkription und daraus folgernd auf die Wirtszellinvasion von S. aureus haben. Letzteres wird vermutlich in manchen Stämmen durch andere Faktoren als die bekannten Invasinproteine Eap und FnBP vermittelt. Außerdem scheint es in den klinischen S. aureus Isolaten mehr als nur den saeSP abhängigen Mechanismus der sae Induktion durch SDS zu geben. Diese Ergebnisse helfen uns die Virulenz und pathogenen Mechanismen als auch deren Regulation in S. aureus zu verstehen. Die Beobachtungen tragen zu unserem Verständnis bei, wie das sae System Signale der Umgebung detektieren kann. Dies ist bis jetzt eine Fragestellung mit vielen Unbekannten
Книги з теми "Sam Newman"
1
What will Dr. Newman do?: John Henry Newman and papal infallibility, 1865-1875. Collegeville, Minn: Liturgical Press, 1994.
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2
Baksha, M. W. Biology, ecology, and management of sal heartwood borer, hoplocerambyx spinicornis newman (cerambycidae : coleoptera) in Bangladesh. Chittagong: Govt. of the People's Republic of Bangladesh, Bangladesh Forest Research Institute, 2000.
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3
Aquino, Frederick D., and Benjamin J. King. Introduction. Edited by Frederick D. Aquino and Benjamin J. King. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198718284.013.30.
Повний текст джерелаАнотація:
This Handbook seeks to explore John Henry Newman with critical appreciation and to assess the large amount of secondary literature. In so doing, it does not intend to protect his legacy but to examine his life, writings, thought, and significance from the different perspectives and disciplines of philosophy, theology, history, education, and literature. Newman himself thought that the attempt to acquire a deeper understanding of things called for more than a single disciplinary perspective. Although a scholar in any particular field works within her boundaries, it is engagement across those boundaries that the present volume seeks to promote while at the same time providing a critical engagement with current scholarship in specific fields. The Handbook does not seek to merge incommensurable readings of Newman into a governing viewpoint and no particular school of thought is privileged. Instead, the volume reflects a broad range of perspectives and methodological assumptions to move all towards deeper understanding.
4
Mercati, Flavio. Barbour–Bertotti Best Matching. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789475.003.0004.
Повний текст джерелаАнотація:
Barbour and Bertotti’s Mach–Poincaré Principle can be realized in classical mechanics with a mathematical procedure which was beyond the grasp of Leibniz or Newton, and turns out to be equivalent to modern gauge theory. This is the formulation of a variational principle based on ‘best matching’: one transforms subsequent configurations of the system with the Euclidean group, and by minimizing a certain functional a notion of ‘equilocality’ is established: now it makes sense to say that a particle comes back to the same point at different times.
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Thomas, Emily. Samuel Clarke’s Evolving Morean Absolutism. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198807933.003.0010.
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Samuel Clarke is best known for the ‘Newtonian’ views on space and time he espouses in the Leibniz-Clarke correspondence. However, his writings on this topic extend far beyond that, and can help us to understand the particulars of Clarke’s metaphysics—including whether he is actually of a mind with Newton. The major part of this chapter considers Clarke’s metaphysical and epistemological views on time and space, arguing that the views Clarke puts forward in various texts can be rendered consistent. It reads Clarke as holding a position close to that of Henry More, and not the same as that of Newton. The minor part of this chapter considers Clarke’s account of divine presence in time and space, and argues that Clarke is a holenmerist.
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The Bible & Polygamy. Does the Bible Sanction Polygamy? A Discussion Between Orson Pratt and J.P. Newman, in the New Tabernacle, Salt Lake City, ... Sermons on the Same Subject. [microform]. Legare Street Press, 2021.
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Lingel, Jessa. An Internet for the People. Princeton University Press, 2020. http://dx.doi.org/10.23943/princeton/9780691188904.001.0001.
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Begun by Craig Newmark as an e-mail to some friends about cool events happening around San Francisco, craigslist is now the leading classifieds service on the planet. It is also a throwback to the early Internet. The website has barely seen an upgrade since it launched in 1996. There are no banner ads. The company doesn't profit off your data. This book explores how people use craigslist to buy and sell, find work, and find love—and reveals why craigslist is becoming a lonely outpost in an increasingly corporatized web. The book looks at the site's history and values, showing how it has mostly stayed the same while the web around it has become more commercial and far less open. It examines craigslist's legal history, describing the company's courtroom battles over issues of freedom of expression and data privacy, and explains the importance of locality in the social relationships fostered by the site. More than an online garage sale, job board, or dating site, craigslist holds vital lessons for the rest of the web. It is a website that values user privacy over profits, ease of use over slick design, and an ethos of the early web that might just hold the key to a more open, transparent, and democratic Internet.
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Soderlund, Jean R. Quaker Women in Lenape Country. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198814221.003.0013.
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This chapter examines the central role of Quaker women during the years 1675–1710 in developing the first colony founded by members of the Society of Friends in North America. As individuals, women Friends helped to fashion a multicultural society consistent with Quaker beliefs in religious liberty and pacifism by maintaining amicable relations with the Lenape Indians and non-Quaker European settlers. At the same time, however, Friends failed to acknowledge the inconsistency of exploiting enslaved African Americans with Quaker ideals. As leaders of the Salem, Burlington, Chesterfield, and Newton (later Haddonfield) monthly meetings, Quaker women also helped to shape West New Jersey society by strengthening rules of discipline to prevent their children and other Friends from marrying non-Quakers and adopting ‘outward vanities’.
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Watt, Gary. Equity & Trusts Law Directions. Oxford University Press, 2019. http://dx.doi.org/10.1093/he/9780198804703.001.0001.
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Without assuming prior legal knowledge, books in the Directions series introduce and guide readers through key points of law and legal debate. Questions, diagrams, and exercises help readers to engage fully with each subject and check their understanding as they progress. This book explains the key topics covered on equity and trusts courses. The content of the text is designed to emphasise the relationship between equity, trusts, property, contract, and restitution to enable students to map out conceptual connections between related legal ideas. There is also a focus on modern cases in the commercial sphere to reflect the constantly changing and socially significant role of trusts and equity. The book starts by introducing equity and trusts. It then includes a chapter on understanding trusts, and moves on to consider capacity and formality requirements, certainty requirements, and the constitution of trusts. Various types of trusts are then examined such as purpose, charitable, and variation trusts. The book then describes issues related to trusteeship. Breach of trust is explained, as is informal trusts of land. There is a chapter on tracing, and then the book concludes by looking at equitable liability of strangers to trust and equitable doctrines and remedies. This new edition includes coverage of significant recent cases, including Patel v Mirza [2016], Supreme Court on the right to recover wealth transferred between parties to an illegal scheme; Burnden Holdings (UK) Ltd v Fielding [2018] UKSC 14; [2018] 2 WLR 885, Supreme Court on limitation of actions; Barnett v Creggy [2016], Court of Appeal on breach of trust and limitation of actions; Singha v Heer [2016], Court of Appeal on facts giving rise to declaration of trust; Clydesdale Bank plc v John Workman [2016], Court of Appeal on dishonest assistance in a breach of trust; Bathurst v Bathurst [2016], on variation of trusts; Newman v Clarke [2016], on fiduciary conflict of interest; RBC Trustees (CI) Ltd v Stubbs [2017], on rectification of a trust deed on the ground of mistake; Erlam v Rahman [2016] EWHC 111 and JSC Mezhdunarodniy Promyshlenniy Bank v Pugachev [2017] EWHC 2426, on ‘sham” trusts’. It also provides coverage of the 2017 Money Laundering, Terrorist Financing and Transfer of Funds Regulations (SI 2017/692 as well as the EU Fourth Money Laundering Directive ((EU) 2015/849), as amended by the The EU Fifth Money Laundering Directive ((EU) 2018/843)
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Webster, Erin. The Curious Eye. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198850199.001.0001.
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The Curious Eye explores early modern debates over two related questions: what are the limits of human vision, and to what extent can these limits be overcome by technological enhancement? Today, in our everyday lives we rely on optical technology to provide us with information about visually remote spaces even as we question the efficacy and ethics of such pursuits. But the debates surrounding the subject of technologically mediated vision have their roots in a much older literary tradition in which the ability to see beyond the limits of natural human vision is associated with philosophical and spiritual insight as well as social and political control. The Curious Eye provides insight into the subject of optically mediated vision by returning to the literature of the seventeenth century, the historical moment in which human visual capacity in the West was first extended through the application of optical technologies to the eye. Bringing imaginative literary works by Francis Bacon, John Milton, Margaret Cavendish, and Aphra Behn together with optical and philosophical treatises by Johannes Kepler, René Descartes, Robert Hooke, Robert Boyle, and Isaac Newton, The Curious Eye explores the social and intellectual impact of the new optical technologies of the seventeenth century on its literature. At the same time, it demonstrates that social, political, and literary concerns are not peripheral to the optical science of the period but rather an integral part of it, the legacy of which we continue to experience.
Частини книг з теми "Sam Newman"
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Roden, Frederick S. "Queer Virginity and the Oxford Movement: Newman and Dalgairns." In Same-Sex Desire in Victorian Religious Culture, 11–34. London: Palgrave Macmillan UK, 2002. http://dx.doi.org/10.1057/9780230513044_2.
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Kulkarni, Nitin, and Subhash Chander. "Hoplocerambyx spinicornis Newman: Major Heartwood Borer of Sal, Shorea robusta and Its Management in India." In Science of Wood Degradation and its Protection, 289–328. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8797-6_9.
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Zaidi, Nayyar A., and Geoffrey I. Webb. "A Fast Trust-Region Newton Method for Softmax Logistic Regression." In Proceedings of the 2017 SIAM International Conference on Data Mining, 705–13. Philadelphia, PA: Society for Industrial and Applied Mathematics, 2017. http://dx.doi.org/10.1137/1.9781611974973.79.
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Schlöter, Miriam, Martin Skutella, and Khai Van Tran. "A Faster Algorithm for Quickest Transshipments via an Extended Discrete Newton Method." In Proceedings of the 2022 Annual ACM-SIAM Symposium on Discrete Algorithms (SODA), 90–102. Philadelphia, PA: Society for Industrial and Applied Mathematics, 2022. http://dx.doi.org/10.1137/1.9781611977073.5.
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Huvet, Chloé. "Thomas Newman/Sam Mendes." In Compositeurs et réalisateurs en duo, 197–217. Presses universitaires de Vincennes, 2022. http://dx.doi.org/10.3917/puv.caryo.2022.01.0197.
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Colby, Jason M. "Murray Newman and Moby Doll." In Orca. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190673093.003.0008.
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For two months, Sam Burich had sat at East Point, on the jagged edge of Saturna Island, staring across the Strait of Georgia and waiting for killer whales. The thirty-eight-year-old Croatian immigrant was not a whaler but a sculptor by trade, though he dabbled in fishing to make ends meet. He had come to East Point at the behest of the Vancouver Aquarium to harvest a whale, not for its blubber or meat but for its body—its form. To pass the time, he played his harmonica, carved hieroglyphs in the sandstone, and chatted with his assistant, twenty-six-year-old fisherman Josef Bauer. On this Thursday, July 16, 1964, just after 11:00 a.m., orcas came into sight. It was J pod, making its way north in pursuit of Fraser River chinook. Bauer saw them first and raced over to load their mounted harpoon gun. Then Burich took over. He knew he would have only one shot as the orcas passed. Most of them were out of range, and Burich needed to hit a whale small enough to kill. Soon he spotted his target, a youngster bobbing along playfully just ninety feet away. Burich took aim and pulled the trigger, detonating the one-and-a-half-ounce powder charge. The steel harpoon, four feet long and two inches thick, hit home. At first, Burich couldn’t believe it, but Bauer’s shouts convinced him. Struck just behind the head, the animal appeared stunned. Burich and Bauer rushed to their boat, the forty-foot Corsair II, moored in a nearby cove. As the men approached the whale, they found a surprising scene. Rather than fleeing from danger, the other orcas had surrounded their injured podmate, raising it to the surface to breathe. It was a touching sight, but Burich knew the reputation of these beasts. Worried the whales would retaliate, like those shot by Marineland’s collectors two years earlier, he and Bauer hung back. Within an hour, the pod had left, and the two men moved in for the kill. But the little orca didn’t want to die.
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Copeland, Jack. "Machine against Machine." In Colossus. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780192840554.003.0012.
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As explained in the preceding chapter, Tutte invented a way of finding the settings of the Tunny’s chi-wheels, but the rub was that his method seemed impractical. It involved calculations which, if done by hand, would consume a vast amount of time—probably as much as several hundred years for a single, long message, Newman once estimated. The necessary calculations were straightforward enough, consisting basically of comparing two streams made up of dots and crosses, and counting the number of times that each had a dot, or cross, in the same position. Today, of course, we turn such work over to electronic computers. When Tutte shyly explained his method to Newman, Newman suggested using high-speed electronic counters to mechanise the process. It was a brilliant idea. Within a surprisingly short time, Newman’s factory of monstrous electronic computers, dedicated to breaking Tunny, was affording a glimpse of the future. Electronic counters had been developed in Cambridge before the war. Used for counting emissions of subatomic particles, these had been designed by C. E. Wynn-Williams, then like Newman a Cambridge don. Newman knew of Wynn-Williams’ work, and in a moment of inspiration he saw that the same idea could be applied to the Tunny problem. Tutte invented his method in November 1942 and the following month Newman was given the job of developing the necessary machinery. Newman worked out the cryptanalytical requirements for the planned machine and called in Wynn-Williams to design the electronic counters. Wynn-Williams was by then involved in wartime research at the Telecommunications Research Establishment (TRE) in Malvern. Newman and TRE approached an expert on teleprinter equipment, F. O. Morrell, head of the telegraph and teleprinter group of the Post Office Research Station at Dollis Hill in North London, to engineer the other parts of the machine. Construction of Newman’s machine started in January 1943 and a prototype began operating in June of that year, in the newly formed Newmanry. The Newmanry consisted initially of Newman himself, Michie, two engineers, and 16 ‘Wrens’—members of the Women’s Royal Naval Service. The section was housed in a two-roomed hut, Hut 11, originally the first Bombe room.
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Rode, Alan K. "Dégringolade." In Michael Curtiz. University Press of Kentucky, 2017. http://dx.doi.org/10.5810/kentucky/9780813173917.003.0032.
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Curtiz returned to Warner Bros. for The Helen Morgan Story (1957).The film, starring Paul Newman and Ann Blyth,wasa flop and turned out to be the director’s final picture for Jack Warner. He fathered a daughter with Jill Gerrard, whom he maintainedat arm’s length to prevent any interference with his film career, which was entering twilight. Sam Goldwyn Jr. hired him to film The Proud Rebel. The film was delayed because of Curtiz’s appendectomy, but it became a heartwarming success starring Alan Ladd and Olivia de Havilland.Hal Wallis tapped him to direct Elvis Presley in King Creole (1958).Taking a conciliatory approach, Curtiz coaxed a superior performance from Presley that the pop music star came to regard as his best in any film. Curtiz directed a pair of desultory pictures,The Man in the Net and A Breath of Scandal, as age and illness began to impair his ability to work effectively.A handsome but antiseptic version of The Adventures of Huckleberry Finn for Sam Goldwyn Jr. closed out Curtiz’s films during the 1950s.
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James, Henry. "XVII." In The American. Oxford University Press, 2009. http://dx.doi.org/10.1093/owc/9780199555208.003.0019.
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Newman was fond of music, and went often to the opera, where, a couple of evenings after Madame de Bellegarde’s ball, he sat listening to ‘Don Giovanni’;* having in honour of this work, which he had never yet seen represented, come to...
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d’Inverno, Ray, and James Vickers. "Rotating black holes." In Introducing Einstein's Relativity, 367–98. 2nd ed. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780198862024.003.0020.
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Abstract Chapter 20, the final chapter in Part D, looks at the Kerr solution, which describes a rotating black hole. It turns out to be a rather long process to solve Einstein’s vacuum equations directly for the Kerr solution, so the chapter instead describes a ‘trick’ used by Newman and Janis for obtaining the Kerr solution from the Schwarzschild solution. This same trick can then be applied to the Reissner–Nordström solution to obtain the Kerr–Newman solution, the most general solution for a charged rotating black hole. After considering the properties of the Kerr solution, the chapter goes on to consider the Penrose process to extract energy from a black hole. It then concludes by providing an outline of the singularity theorems and introducing Hawking radiation and black hole thermodynamics.
Тези доповідей конференцій з теми "Sam Newman"
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Leng, Tan Soo, James C. P. McKeon, and Hyo Seong Jang. "Correlation Study of Delamination Gap Detection Capability of SAM and Cross Section/SEM Analysis." In ISTFA 2006. ASM International, 2006. http://dx.doi.org/10.31399/asm.cp.istfa2006p0480.
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Abstract Previous work on determining the minimal air gap detectable in scanning acoustic microscope (SAM) focused on the gap thickness detectable in an idealized Newton ring sample using a 75 MHz transducer. However, air gaps thinner than 0.130 microns have been detected by SAM. These findings have prompted a return to the question of what is the minimal air gap detectability of SAM. To answer this question, further, Newton Ring experiments using transducers across the SAM frequency range have been performed. This article discusses the processes involved in these experiments and provides the results of SAM from actual packages. The procedure involved in cross-sectioning and scanning electron microscopy (SEM) imaging for correlating samples is also provided. Based on the SAM-cross-sectioning-SEM analysis, a detection of 0.056 - 0.183 micron air gaps was concluded for the delamination areas detected by SAM using a 35 MHz 12 mm transducer.
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Addario-Berry, Louigi, and Tao Lei. "The mixing time of the Newman–Watts small world." In Proceedings of the Twenty-Third Annual ACM-SIAM Symposium on Discrete Algorithms. Philadelphia, PA: Society for Industrial and Applied Mathematics, 2012. http://dx.doi.org/10.1137/1.9781611973099.131.
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Muslubas, Yunus Emre, and Sinan Eyi. "Analysis of Hypersonic Nozzles with Newton and Preconditioned Newton-GMRES Methods." In 51st AIAA/SAE/ASEE Joint Propulsion Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2015. http://dx.doi.org/10.2514/6.2015-3746.
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Llanes, Jose Damian, Alejo Viñales, and Juan Juri. "Assisted 3D Model Construction and Facies Propagation in Golfo San Jorge Basin Reservoirs for Modelling EOR." In SPE Improved Oil Recovery Conference. SPE, 2022. http://dx.doi.org/10.2118/209400-ms.
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Abstract Three-dimensional modelling is at the critical path to map the by-passed oil in multilayer fluvial systems in the San Jorge Basin. Integrated reservoir modelling teams dedicate an important amount of time to create these three-dimensional models to decrease risk pursuing chemical injection for enhanced oil recovery. Traditional static reservoir modelling requires an important effort from the geologist to construct the interwell correlation. The objective of this work is to show the implementation of two unsupervised algorithms to automate/assist integrated reservoir modelling. We create multiple possible three-dimensional models of real multilayer static reservoirs and accelerate simulation. The first part of the work obtains the stratigraphic representation of the entire reservoir structure. We use the available lithology well logs as spontaneous potential and gamma ray to identify automatically the permeable and shale rocks with unbiased interpretation by their deflection responses in each well for the entire target reservoirs. Then we construct a graph in which each of the deflections is represented by a node. The edges that join each pair of nodes have an assigned weight depending on the difference in depth and the distance in plan of the nodes. We draw edge weights from a multivariate distribution with interwell distances and dipping angle. Then we use an adapted version of the Girvan-Newman algorithm to make a community detection by eliminating nongeological connections/features, to find the community with greater modularity. These communities represent the existing correlations between the deflections of the different wells. In the second part of this work, we obtain the facies distribution in the reservoir, using one-, two- and three-dimensional Markov chains. We implemented Jaccard distance to measure the mismatch of geological features and objects between the true synthetic case and the reconstructed model. With the modified Girvan-Newman algorithm we obtained multiple stratigraphic representations similar to the 3D model created by a geologist. Through modeling of two incomplete synthetic cross section cases using Markov chain propagation of a transition matrix the reconstruction reveals that we recover 90% of the original case even when we Input only 5% of the true data initially in the model. Then we tested a very fine real three-dimensional case created by an experienced geologist. The Markov reconstruction algorithm was able to recover up to 60 percent of the model true real three-dimensional model. The analysis of the reconstructed model features reveals that the Jaccard distance is a reliable indicator of the geological features. Using the computational algorithms implemented, it is possible to obtain a stratigraphic model and the facies model in less than four hours speeding up reservoir modeling. And core data is sufficient to recover a reasonable model to input to the simulator.
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Lahmar, F., and P. Velex. "Simulations of Gear-Rolling Element Bearing Interactions in Geared Transmissions." In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/ptg-48040.
Повний текст джерелаАнотація:
The modular model of geared systems presented in this paper makes it possible to simultaneously account for the contact conditions in gears and rolling element bearings. Gears are modeled as two rigid cylinders connected by distributed mesh stiffnesses while ball and roller bearings contribute to the equations of motion as time-varying, non-linear external forces. Solutions are obtained by combining a Newmark time-step integration scheme, a Newton-Raphson method for ball bearing non-linearity and a normal contact algorithm that deals with the contact problem between the teeth. It is found that the static gear-bearing couplings are generally more important than the dynamic couplings with a significant influence of the gear on the bearing response. Finally, it is shown that, in certain conditions, bearings can generate non-linear parametric excitations of the same orders of magnitude as those associated with the meshing of helical gears.
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Rustem, Berc. "A Newton-type min-max algorithm for rival models of the same system." In 1986 25th IEEE Conference on Decision and Control. IEEE, 1986. http://dx.doi.org/10.1109/cdc.1986.267530.
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Pierce, William C. "Neway Drive Axle Air Suspension." In SAE International Truck and Bus Meeting and Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1988. http://dx.doi.org/10.4271/881871.
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Franchois, Anne, and Christian Pichot. "Generalized cross-validation applied to a Newton-type algorithm for microwave tomography." In San Diego '92, edited by Michael A. Fiddy. SPIE, 1992. http://dx.doi.org/10.1117/12.139019.
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Gollor, Matthias, and Michael Boss. "Micro-Newton Electric Propulsion Subsystems for Ultra-Stable Platforms." In 42nd AIAA/ASME/SAE/ASEE Joint Propulsion Conference & Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2006. http://dx.doi.org/10.2514/6.2006-4825.
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Yıldırım, Ali, and Sinan Eyi. "Three Dimensional Design Optimization Using Adjoint Method with Newton Krylov Solver." In 52nd AIAA/SAE/ASEE Joint Propulsion Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2016. http://dx.doi.org/10.2514/6.2016-4802.
Повний текст джерелаЗвіти організацій з теми "Sam Newman"
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Chemistry and isotopic composition of ground water along a section near the Newmark area, San Bernardino County, California. US Geological Survey, 1998. http://dx.doi.org/10.3133/wri974179.
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