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Добірка наукової літератури з теми "SBVS"

Автор: Grafiati

Опубліковано: 14 березня 2023

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Статті в журналах з теми "SBVS"

Haddison, Eposi C., Leila H. Abdullahi, Rudzani Muloiwa, Gregory D. Hussey, and Benjamin M. Kagina. "Comparison of school based and supplemental vaccination strategies in the delivery of vaccines to 5-19 year olds in Africa - a systematic review." F1000Research 6 (October 13, 2017): 1833. http://dx.doi.org/10.12688/f1000research.12804.1.

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Background: Some vaccine preventable diseases (VPDs) still remain a public health burden in many African countries. The occurrence of VPDs in all age groups has led to the realization of the need to extend routine immunisation services to school age children, adolescents and adults. Supplemental immunisation activities (SIAs) and school based vaccinations (SBVs) are common strategies used to complement the expanded programme on immunisation (EPI). This review aimed to assess the effectiveness of SIAs compared to SBVs in the administration of vaccines to 5-19 year olds in Africa. Methods: Systematic review methods were used to address our study aim. Several electronic databases were searched up to March 30, 2017 for primary studies investigating the delivery of vaccines via SIAs or SBVs to 5-19 year olds. This search was complemented by browsing reference lists of potential studies obtained from search outputs. Outcomes considered for inclusion were: vaccination coverage, costs of the strategy or its effect on routine immunisation services. Results: Out of the 4938 studies identified, 31 studies met the review inclusion criteria. Both SIAs and SBVs showed high vaccination coverage. However, the SIAs reported higher coverage than SBVs: 91% (95% CI: 84%, 98%) versus 75% (95% CI: 67%, 83%). In most settings, SBVs were reported to be more expensive than SIAs. The SIAs were found to negatively affect routine immunisation services. Conclusions: Both SIAs and SBVs are routinely used to complement the EPI in the delivery of vaccines in Africa. In settings where school enrolment is suboptimal, as is the case in many African countries, our results show SIAs may be more effective in reaching school age children and adolescents than SBVs. Our results re-iterate the importance of evaluating systematic evidence to best inform African authorities on the optimal vaccine delivery strategies targeting school age children and adolescents.

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Istyastono, Enade Perdana. "Binary Quantitative Structure-Activity Relationship Analysis to Increase the Predictive Ability of Structure-Based Virtual Screening Campaigns Targeting Cyclooxygenase-2." Indonesian Journal of Chemistry 17, no. 2 (July 31, 2017): 322. http://dx.doi.org/10.22146/ijc.24172.

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Structure-Based Virtual Screening (SBVS) campaigns employing Protein-Ligand Interaction Fingerprints (PLIF) identification have served as a powerful strategy in fragments and ligands identification, both retro- and prospectively. Most of the SBVS campaigns employed PLIF by comparing them to a reference PLIF to calculate the Tanimoto-coefficient. Since the approach was reference dependent, it could lead to a very different discovery path if a different reference was used. In this article, references independent approach, i.e. decision trees construction using docking score and PLIF as the descriptors to increase the predictive ability of the SBVS campaigns in the identification of ligands for cyclooxygenase-2 is presented. The results showed that the binary Quantitative-Structure Activity Relationship (QSAR) analysis could significantly increase the predictive ability of the SBVS campaign. Moreover, the selected decision tree could also pinpoint the molecular determinants of the ligands binding to cyclooxygenase-2.

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Istyastono, Enade P., Florentinus Dika Octa Riswanto, Nunung Yuniarti, Vivitri D. Prasasty, and Sudi Mungkasi. "PyPLIF HIPPOS and Receptor Ensemble Docking Increase the Prediction Accuracy of the Structure-Based Virtual Screening Protocol Targeting Acetylcholinesterase." Molecules 27, no. 17 (September 2, 2022): 5661. http://dx.doi.org/10.3390/molecules27175661.

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In this article, the upgrading process of the structure-based virtual screening (SBVS) protocol targeting acetylcholinesterase (AChE) previously published in 2017 is presented. The upgraded version of PyPLIF called PyPLIF HIPPOS and the receptor ensemble docking (RED) method using AutoDock Vina were employed to calculate the ensemble protein–ligand interaction fingerprints (ensPLIF) in a retrospective SBVS campaign targeting AChE. A machine learning technique called recursive partitioning and regression trees (RPART) was then used to optimize the prediction accuracy of the protocol by using the ensPLIF values as the descriptors. The best protocol resulting from this research outperformed the previously published SBVS protocol targeting AChE.

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Lucumi, Armando, Sara Robledo, Vivian Gama, and Nancy G. Saravia. "Sensitivity of Leishmania viannia panamensis to Pentavalent Antimony Is Correlated with the Formation of Cleavable DNA-Protein Complexes." Antimicrobial Agents and Chemotherapy 42, no. 8 (August 1, 1998): 1990–95. http://dx.doi.org/10.1128/aac.42.8.1990.

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ABSTRACT The emergence of Leishmania less sensitive to pentavalent antimonial agents (SbVs), the report of inhibition of purified topoisomerase I of Leishmania donovani by sodium stibogluconate (Pentostam), and the uncertain mechanism of action of antimonial drugs prompted an evaluation of SbVs in the stabilization of cleavable complexes in promastigotes of Leishmania(Viannia). The effect of camptothecin, an inhibitor of topoisomerase, and additive-free meglumine antimoniate (Glucantime) on the stabilization of cleavable DNA-protein complexes associated with the inhibition of topoisomerase was assessed in the human promonocytic cell line U-937, promastigotes of L. (Viannia)panamensis selected for SbV resistance in vitro, and the corresponding wild-type strain. The stabilization of cleavable complexes and the 50% effective dose (ED50) of SbVs for parasites isolated from patients with relapses were also evaluated. The median ED50 for the wild-type strain was 16.7 μg of SbV/ml, while that of the line selected for resistance was 209.5 μg of SbV/ml. Treatment with both meglumine antimoniate and sodium stibogluconate (20 to 200 μg of SbV/ml) stabilized DNA-protein complexes in the wild-type strain but not the resistant line. The ED50s of the SbVs for Leishmania strains from patients with relapses was comparable to those for the line selected for in vitro resistance, and DNA-protein complexes were not stabilized by exposure to meglumine antimoniate. Cleavable complexes were observed in all Leishmania strains treated with camptothecin. Camptothecin stabilized cleavable complexes in U-937 cells; SbVs did not. The selective effect of the SbVs on the stabilization of DNA-protein complexes in Leishmania and the loss of this effect in naturally resistant or experimentally derived SbV-resistantLeishmania suggest that topoisomerase may be a target of antimonial drugs.

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Istyastono, Enade Perdana, Nunung Yuniarti, Maywan Hariono, Sri Hartati Yuliani, and Florentinus Dika Octa Riswanto. "BINARY QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS IN RETROSPECTIVE STRUCTURE-BASED VIRTUAL SCREENING CAMPAIGNS TARGETING ESTROGEN RECEPTOR ALPHA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 12 (December 1, 2017): 206. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.20667.

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Objective: The objective of this study is to construct predictive unbiased structure-based virtual screening (SBVS) protocols to identify potent ligands for estrogen receptor alpha by combining molecular docking, protein-ligand interaction fingerprinting (PLIF), and binary quantitative structure-activity relationship (QSAR) analysis using recursive partition and regression tree method.Methods: Employing the enhanced version of a directory of useful decoys, SBVS protocols using molecular docking simulations, and PLIF were constructed and retrospectively validated. To avoid bias, SMILES format of the compounds was used. The predictive abilities of the SBVS protocols were then compared based on the enrichment factor (EF) and the F-measure values.Results: The SBVS protocols resulted in this research were SBVS_1 (employing docking scores of the best pose on every compound to rank the results and selecting compounds within 1% false positives as positive), SBVS_2 (employing decision tree resulted from the binary QSAR analysis using docking scores and PLIF bitstrings of the best pose of every compound as descriptors), and SBVS_3 (employing decision tree resulted from the binary QSAR analysis using ensemble PLIF of the selected poses from optimized docking score as the cutoff). The EF values of SBVS_1, SBVS_2, and SBVS_3 are 28.315, 576.084, and 713.472, respectively, while their F-measure values are 0.310, 0.573, and 0.769, respectively.Conclusion: Highly predictive unbiased SBVS protocols to identify potent estrogen receptor alpha ligands were constructed. Further application in prospective screening is therefore highly suggested.

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Lee, Yuno, Sae-Bom Yoon, Hyowon Hong, Hyun Young Kim, Daeyoung Jung, Byoung-San Moon, Woo-Kyu Park та ін. "Discovery of GSK3β Inhibitors through In Silico Prediction-and-Experiment Cycling Strategy, and Biological Evaluation". Molecules 27, № 12 (14 червня 2022): 3825. http://dx.doi.org/10.3390/molecules27123825.

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Direct inhibitors of glycogen synthase kinase 3β (GSK3β) have been investigated and reported for the past 20 years. In the search for novel scaffold inhibitors, 3000 compounds were selected through structure-based virtual screening (SBVS), and then high-throughput enzyme screening was performed. Among the active hit compounds, pyrazolo [1,5-a]pyrimidin-7-amine derivatives showed strong inhibitory potencies on the GSK3β enzyme and markedly activated Wnt signaling. The result of the molecular dynamics (MD) simulation, enhanced by the upper-wall restraint, was used as an advanced structural query for the SBVS. In this study, strong inhibitors designed to inhibit the GSK3β enzyme were discovered through SBVS. Our study provides structural insights into the binding mode of the inhibitors for further lead optimization.

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Yuniarti, Nunung, Sudi Mungkasi, Sri Hartati Yuliani, and Enade Perdana Istyastono. "Development of a Graphical User Interface Application to Identify Marginal and Potent Ligands for Estrogen Receptor Alpha." Indonesian Journal of Chemistry 19, no. 2 (April 9, 2019): 531. http://dx.doi.org/10.22146/ijc.34561.

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Employing ensemble Protein-Ligand Interaction Fingerprints (ensPLIF) as descriptors in post retrospective Structure-Based Virtual Screening (SBVS) campaigns Quantitative Structure-Activity Relationship (QSAR) analysis has been proven to significantly increase the predictive ability in the identification of potent ligands for estrogen receptor alpha (ERα). In the research presented in this article, similar approaches have been performed to construct and retrospectively validate an SBVS protocol to identify marginal ligands for ERα. Based on both validated SBVS protocols, a graphical-user-interface (GUI) application to identify if a compound is a non-, moderate or potent ligand for ERα was developed. The GUI application was subsequently used to virtually screen genistin, genistein, daidzin, and daidzein, followed by in vitro test employing a cytotoxic assay using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method.

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Istyastono, Enade Perdana. "CONSTRUCTION AND OPTIMIZATION OF STRUCTURE-BASED VIRTUAL SCREENING PROTOCOLS TO IDENTIFY CYCLOOXYGENASE-1 INHIBITORS USING OPEN BABEL, SPORES AND PLANTS." Indonesian Journal of Chemistry 12, no. 2 (June 4, 2012): 141–45. http://dx.doi.org/10.22146/ijc.21354.

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Structure-Based Virtual Screening (SBVS) protocols to identify cyclooxygenase-1 (COX-1) inhibitors have been constructed and optimized based on their Root Mean Square Deviation (RMSD) values of the docked pose and the crystal structure pose of the reference ligand. Employing a COX-1 structure obtained from the Protein Data Bank (pdb) with code 2OYE as the reference protein and PLANTS1.2 as the molecular docking simulation program, the SBVS protocols were mainly built. The preparation steps involved SPORES and Open Babel, while the results analysis involved PyMOL to calculate the RMSD and R computational statistics software to perform the statistics calculations. The results show that these construction and optimization processes could provide an SBVS protocol to identify COX-1 inhibitors that is accurately able to redock the reference ligand with the RMSD value of 0.633 Å.

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Zhu, Hui, Yulin Zhang, Wei Li, and Niu Huang. "A Comprehensive Survey of Prospective Structure-Based Virtual Screening for Early Drug Discovery in the Past Fifteen Years." International Journal of Molecular Sciences 23, no. 24 (December 15, 2022): 15961. http://dx.doi.org/10.3390/ijms232415961.

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Structure-based virtual screening (SBVS), also known as molecular docking, has been increasingly applied to discover small-molecule ligands based on the protein structures in the early stage of drug discovery. In this review, we comprehensively surveyed the prospective applications of molecular docking judged by solid experimental validations in the literature over the past fifteen years. Herein, we systematically analyzed the novelty of the targets and the docking hits, practical protocols of docking screening, and the following experimental validations. Among the 419 case studies we reviewed, most virtual screenings were carried out on widely studied targets, and only 22% were on less-explored new targets. Regarding docking software, GLIDE is the most popular one used in molecular docking, while the DOCK 3 series showed a strong capacity for large-scale virtual screening. Besides, the majority of identified hits are promising in structural novelty and one-quarter of the hits showed better potency than 1 μM, indicating that the primary advantage of SBVS is to discover new chemotypes rather than highly potent compounds. Furthermore, in most studies, only in vitro bioassays were carried out to validate the docking hits, which might limit the further characterization and development of the identified active compounds. Finally, several successful stories of SBVS with extensive experimental validations have been highlighted, which provide unique insights into future SBVS drug discovery campaigns.

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Chang, Ju-Chun, Zih-Ting Chang, Chong-Yu Ko, Yue-Wen Chen, and Yu-Shin Nai. "Genomic Sequencing and Comparison of Sacbrood Viruses from Apis cerana and Apis mellifera in Taiwan." Pathogens 10, no. 1 (December 28, 2020): 14. http://dx.doi.org/10.3390/pathogens10010014.

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Sacbrood virus (SBV) was the first identified bee virus and shown to cause serious epizootic infections in the population of Apis cerana in Taiwan in 2015. Herein, the whole genome sequences of SBVs in A. cerana and A. mellifera were decoded and designated AcSBV-TW and AmSBV-TW, respectively. The whole genomes of AcSBV-TW and AmSBV-TW were 8776 and 8885 bp, respectively, and shared 90% identity. Each viral genome encoded a polyprotein, which consisted of 2841 aa in AcSBV-TW and 2859 aa in AmSBV-TW, and these sequences shared 95% identity. Compared to 54 other SBVs, the structural protein and protease regions showed high variation, while the helicase was the most highly conserved region among SBVs. Moreover, a 17-amino-acid deletion was found in viral protein 1 (VP1) region of AcSBV-TW compared to AmSBV-TW. The phylogenetic analysis based on the polyprotein sequences and partial VP1 region indicated that AcSBV-TW was grouped into the SBV clade with the AC-genotype (17-aa deletion) and was closely related to AmSBV-SDLY and CSBV-FZ, while AmSBV-TW was grouped into the AM-genotype clade but branched independently from other AmSBVs, indicating that the divergent genomic characteristics of AmSBV-TW might be a consequence of geographic distance driving evolution, and AcSBV-TW was closely related to CSBV-FZ, which originated from China. This 17-amino-acid deletion could be found in either AcSBV or AmSBV in Taiwan, indicating cross-infection between the two viruses. Our data revealed geographic and host specificities between SBVs. The amino acid difference in the VP1 region might serve as a molecular marker for describing SBV cross-infection.

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Більше джерел

Дисертації з теми "SBVS"

Fiorucci. "On the Chitinase target evolution, from fungi to humans." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1048358.

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Chitinase proteins are expressed in most of reigns, from fungi to mammals. This kind of proteins can cleave the chitin, the second most abundant polysaccharide in nature. Mammals do not synthesize nor are able to use it, but they express Chitinase proteins. It has been proved that this kind of proteins are involved in several pathologies. Human Acidic Mammalian Chitinase is involved in the development of pathologies related to the Th2 inflammation. It has been discovered that the inhibition of this protein allowed the reduction of the inflammation. This effect makes this protein a very interesting target for the treatment of this kind of pathologies. In this PhD thesis, the first subject is the target fishing procedure applied to a series of macrocyclic compounds endowed with antifungal activity. The result of the target fishing has been the chitinase protein, and it has been rationally designed a new derivative able to inhibit the chitinase protein with higher potency. The second theme of this work has been the computational study the complex between the rationally designed chitinase inhibitor and the human Acidic Mammalian Chitinase, to identify the most reliable binding mode of the compound inside the binding pocket. The identification of the binding mode has been followed by the design of a library of derivatives, using the information acquired after the study, to improve the activity of the series of compounds towards the Acidic Mammalian Chitinase. The last topic has been the Structure Based Virtual Screening on the Acidic Mammalian Chitinase to find novel scaffolds active as AMCase inhibitor. A first screening based on pharmacophoric filtration and docking calculations has been done, identifying a preliminary hit, on which it has been performed a substructure search, that allowed the discovery of a more active derivative. This molecule has been examined with Molecular Dynamics simulations observing modification in the binding mode during each replica. It has been done a cluster analysis used for the generation of a new pharmacophoric model. The selected cluster representatives have been used as receptors for an ensemble docking calculation that allowed the identification of a third molecule biologically active as AMCase inhibitor.

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Pocius, Arvydas. "SBVR struktūrizuotos natūralios kalbos klausimų redagavimo įrankis." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130826_150609-84648.

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Ontologijos užklausų rašymas paprastiems vartotojams yra per daug sudėtingas. Vartotojai labiausiai mėgsta pateikti užklausas natūralia kalba. Tačiau dar nėra sukurtų programų, kurios suprastų tikrą natūralią kalbą. Šiuo metu galimas sprendimas yra naudoti ribotą (struktūrizuotą) natūralią kalbą, kuri sudaroma pagal tam tikrus šablonus. Sukūrus SBVR metamodeliu grindžiamą struktūrizuotos natūralios kalbos užklausų redaktorių, vartotojui nereikėtų specialistų pagalbos norint peržiūrėti ontologijų duomenis. Informaciją būtų galima peržiūrėti rašant klausimus struktūrizuota natūralia kalba. Šiame darbe nekeliamas tikslas iš struktūrizuotos kalbos klausimų gauti SPARQL užklausas, kadangi tai būtų per didelis uždavinys. Šio darbo tikslas yra atpažinti ir struktūrizuoti įvedamą tekstą, kad vėliau būtų galima generuoti XMI schemą ir transformuoti ją į SPARQL užklausas.
Ontology query writing for ordinary users too complicated. People mostly like to submit queries in natural language. However, software systems that could understand natural language do not exist yet. A possible solution is to use a limited (structured) natural language, which is formed according to certain patterns. Users having a structured natural language question editor based on SBVR metamodel would be able to analyse ontology data without help of professionals. They could write questions in structured natural language which is understandable for humans and computers. This work is not intended to transform structured questions into SPARQL queries, since it would be too big task. The aim of this work is to identify and formalize textual questions, typed by users, for subsequent generation of XMI schema and transforming them into a SPARQL queries.

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Manaf, Nurulhuda A. "Generating verifiable service choreographies from SBVR models." Thesis, University of Surrey, 2018. http://epubs.surrey.ac.uk/845645/.

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Guaranteeing the correct coordination of distributed applications that are built up as networks of autonomous participants, e.g., software components, web services, online resources, software as a service (SaaS) peers, is inherently challenging. This is obvious when the current distributed applications involve a collaboration between loosely-coupled services on distinct providers; the ordering of interactions that may further affects the dependencies between different participants, including control flow dependencies (e.g., a given service invocation must occur before another one), time constraints, and transactional dependencies. This complexity of the development of distributed applications illustrates how important the techniques and approaches for designing and coordinating the service interactions between distinct participant services to ensure that the overall goal of the collaboration between participant services is achieved. Standardisation efforts to date have resulted in the Web Services Choreography Description Language (WS-CDL), a specification protocol advocated by W3C. WS-CDL and other modeling languages (e.g., UML2) provide various divergent semantics and less user-friendly graphical notation. On the other hand the formal approach would allow unambiguous specification and verification of the intended collaboraton. In this research work, a declarative approach was proposed for specifying coordination of distributed applications involving distinct participant services which is being able to verify that it is correct. The proposed approach could captures and describing the complex interactions that involves the ordering of service interaction based on the given global constraints. A new model using a declarative approach, an OMG standard Semantics of Business Vocabulary and Rules (SBVR) model was introduced for specifying service choreography. This SBVR model is then formulated and transformed into Alloy model using Alloy Analyzer for verification. A fully automated SBVR2Alloy tool was implemented for transforming from the developed SBVR model into the Alloy model. This proposed model is targeted to enable the practitioners (business analysts, developers) to devise and set up the service choreographies that realise their collaborations by generating the automated verifiable choreography model.

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Albarici, Fabio Luiz. "Posicionamento relativo: análise dos resultados combinando as observáveis L1 dos satélites GPS e SBAS." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/3/3138/tde-01062011-135146/.

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Os sistemas de aumento, conhecidos como SBAS (Satellite-Based Augmentation System) fornecem informações de integridade e acurácia em tempo real para seus usuários, utilizando-se das correções diferenciais que são transmitidas pelos satélites geoestacionários e estão disponíveis em algumas regiões do globo terrestre. Fora da sua região de abrangência o sistema ainda não disponibiliza os dados de correção em tempo real. Entretanto, o sinal é transmitido na mesma frequência L1 do GPS, o qual fica disponível aqui no Brasil, e alguns receptores GNSS possuem canais de frequência especifica que captam este sinal, com a perspectiva de que os dados destes satélites melhoram as condições do rastreio, além da melhoria na acurácia das coordenadas. Partindo deste princípio, foi utilizada a observável fase da onda portadora (L1) para inferir sobre a sua contribuição para o posicionamento. Os rastreios foram realizados em diferentes localidades devido à elevação dos satélites SBAS variar em função da latitude e longitude. Contudo, este estudo foi direcionado para os dados dos satélites PRN 138 (WAAS), PRN 120 e 124 (EGNOS), pois foram os únicos visíveis durante todo o rastreio, tendo simultaneidade dos dados entre os receptores base e móvel. Durante a etapa de processamento, o qual foi utilizado o software GNSS Solution, alguns experimentos foram realizados, tais como: 1) Processamento com todas as observáveis L1 dos satélites disponíveis (GPS e SBAS), análise dos desvios-padrão e comparação das coordenadas obtidas com as consideradas verdadeiras; 2) Processamento sem as observáveis L1 dos satélites SBAS, análises e comparações; 3) Retirada gradativa dos satélites GPS e reprocessamento em conjunto (GPS+SBAS) e separadamente (apenas GPS). A finalidade principal desses experimentos foi verificar a potencialidade da observável L1 dos satélites SBAS processadas em conjunto com a observável L1 do GPS, no posicionamento relativo. Análises estatísticas, como tendência e erro médio quadrático (RMS), foram aplicadas para verificar a existência de erros sistemáticos e a acurácia das coordenadas. Os resultados mostram que, especificamente nos locais de rastreio, as observáveis L1 dos satélites SBAS ao serem adicionados ao processamento, combinado com as observáveis L1 dos satélites GPS, não são determinantes para melhoria da acurácia das coordenadas.
The augmentation systems, known as SBAS (Satellite-Based Augmentation System) provide information for completeness and accuracy in real time to its users, using the differential corrections that are transmitted by geostationary satellites. They are available in specific regions of the globe such as USA, Canada and Europe. Outside their region of coverage the system still does not provide the correction data in real time. However, the signal is transmitted at the same frequency L1 GPS, which is available here in Brazil, and some GNSS receivers have specific frequency channels that capture this signal, with the prospect that the data from these satellites improve the conditions of screening, besides improving the accuracy of the coordinates. With this assumption, we used the observed phase of the carrier wave (L1) to infer its contribution to the placement. The surveys were conducted in various locations due to rising SBAS satellites vary with latitude and longitude. However, this study was directed to the data from the WAAS satellites (PRN 138) and EGNOS (PRN 120 and 124) because they were the only visible throughout the screening taking simultaneity between the base and mobile receivers. During the processing stage, which was used the software GNSS Solution, some experiments were performed, such as: 1) Processing with all the L1 observable from available satellites (GPS and SBAS), analysis of standard deviations and comparison of the coordinates obtained with the true, 2) processing without observable L1 SBAS satellites, analysis and comparisons, 3) gradual withdrawal of the GPS satellites and reprocessing together (GPS + SBAS) and separately (GPS only). The main purpose of these experiments was to investigate the potential of the L1 observable processed SBAS satellites together with GPS L1 observable in the relative positioning. Statistical analysis such as trending and root mean square (RMS) were applied to verify the existence of systematic errors and accuracy of these coordinates. The results show that, specifically at sites of screening, the observables L1 SBAS satellites to be added to the processing, combined with the L1 observable GPS satellites, are not decisive for improving the accuracy of the coordinates.

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Wong, Chi Chown. "Function of the SBDS gene in Dictyostelium discoideum." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611479.

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Jesus, Jandisson Soares de. "Um método para a implementação de regras de negócio à partir da semântica SBVR." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/45/45134/tde-22012014-144303/.

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A implementação das regras de negócio em sistemas de informação não é uma atividade trivial. Isso acontece porque os modelos utilizados para representá-las não determinam como elas podem ser efetivamente implementadas em situações reais. Neste trabalho é proposta um método para a transformação das regras de negócio descritas em SBVR para um modelo de implementação. Essa tradução é feita mapeando todos os elementos relevantes do modelo em SBVR em um modelo em $\\pi$-calculus baseado em eventos. Neste modelo, existe uma representação explícita de todos os eventos que precisam ser monitorados a fim de identificar quando a regra pode ter sido violada. O objetivo é facilitar o gerenciamento das regras de negócio ao permitir que elas permaneçam separadas dos outros elementos da arquitetura e com isso possam ser gerenciadas de forma independente.
The implementation of business rules in an information system is not an easy task. This happens because most of the models used to represent them capture only the meaning of the rules and do not provide means to make them to be effectively implemented. In this work we provide an approach for the translation from a SBVR semantic description of business rules into a implementation model. This was done by mapping all relevant elements of the SBVR semantic representation into a $\\pi$-calculus event-driven model. On this model will be described explicitly all the events that must be monitored in order to identify when some rule may have been violated. This makes the business rule implementation easier because there is a explicit indication of the moment when make sense to do a verification in order to see if any rule was violated. Besides that, it easier the business rule management since the rules stay separate from the others elements of the system architecture and in this way can be managed independently.

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Guay, Jean-Christophe. "Récepteur SBAS-GNSS logiciel pour des applications temps-réel." Mémoire, École de technologie supérieure, 2010. http://espace.etsmtl.ca/642/1/GUAY_Jean%2DChristophe.pdf.

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Le positionnement par satellites est à un point déterminant de son existence. La modernisation des systèmes américain (GPS – Global Positioning System) et russe (GLONASS - GLObal Navigation Satellite System) ainsi que la venue des systèmes européen (Galileo) et chinois (COMPASS) permettront une multitude de nouvelles applications. Ce regroupement de systèmes de positionnement par satellites (GNSS - Global Navigation Satellite System) ainsi que le système d’augmentation du GPS (SBAS - System Based Augmentation System) permettront d’améliorer l’intégrité, la disponibilité, la précision et la vulnérabilité électromagnétique. Afin de profiter au maximum de ces nouveaux signaux, les récepteurs GNSS devront être repensés. L’objectif de ce mémoire consiste à développer un récepteur multifréquence SBAS-GNSS logiciel pour des applications en temps-réel afin de tirer profit de ces nouveaux signaux GNSS. Pour atteindre cet objectif, une architecture de canal BPSK (Binary Phase Shift Keying) satisfaisant plusieurs signaux GNSS a été implémentée. Ces signaux sont : GPS L1 C/A, GPS L2C, SBAS L1, SBAS L5, GLONASS L1 et GLONASS L2. De plus, ce mémoire se concentre aussi sur l’implémentation d’une solution SBAS complète permettant d’améliorer la précision de la solution de navigation. Le canal générique BPSK réalisé permet de poursuivre à la perfection les signaux GPS L1 C/A, SBAS L1, SBAS L5, GLONASS L1, GLONASS L2, COMPASS B1 et COMPASS B2 couvrant ainsi toute la bande GNSS de 1176 MHz à 1602 MHz. Ce canal BPSK ne dégrade aucunement les performances du récepteur SBAS-GNSS comparativement à un canal GPS L1 C/A. En fait, la précision horizontale est passée de 2,3 m à 1 σ à 1,1 m à 1 σ avec quelques ajustements mineurs. De plus, l’implémentation d’un algorithme de lissage via la porteuse améliore cette précision jusqu’à 0,96 m à 1 σ. Le cercle de probabilité de 50% (CEP) pour cette solution lissée est de 0,62 m et celui de 95% de probabilité (R95) est de 2,21 m. Finalement, l’implémentation de la solution SBAS améliore ces performances à 0,73 m à 1 σ, à un CEP de 0,44 m et à un R95 de 1,4 m. Bref, une amélioration de 70% peut être observée entre les travaux précédents et ceux actuels lorsque l’on en compare les performances à 1 σ. De plus, les nouveaux canaux et algorithmes ont également été testés en dynamique. Une amélioration de 5 % peut être observée sur l’écart-type de l’erreur relative à une solution Real-Time Kinematics (RTK).

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Graisithikul, Gunyarat. "Comparing Access Control Security Policies : A Case Study Using SBVR." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-108306.

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Companies today are required more and more to interconnect their information systems with partners and suppliers in order to be competitive in a global marketplace. A problem of how to compare a security policy between two different companies when they need to agree upon a single security policy has been raised. Can a comparison of two access control policies made through Semantic of Business Vocabulary and Business Rules (SBVR) be more appropriate than the traditional way of intuitively comparing two information security policies? In this research, a case study has been conducted along with the questionnaires as a data collection approach. In the case study, a calculation for a degree of policy statement similarity of Company A’s and Company B has been done. Both calculations were based on the questionnaire results of the Company A and Company B in form of SBVR and traditional policy statements separately. This research has revealed that SBVR applied policy is more appropriate for comparing two company policies than a traditional written policy. By applying SBVR to the policy statements, Company A and Company B had their policy in the same structure, which is in the SBVR format. They could get a very clear similar part of the policy statements (70% calculated by the results of the second questionnaire in this case study) agreed by both companies.

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Bajwa, Imran Sarwar. "A natural language processing approach to generate SBVR and OCL." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4890/.

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The Object Constraint Language (OCL) is a declarative language and is used to make the Unified Modeling Language (UML) models well-defined through defining a set of constraints. However, the syntactic complexity of OCL makes the writing of OCL code difficult. A natural language based interface can be useful in making the process of writing OCL expressions easy and simple. However, the translation of natural language (NL) text to object constraint language (OCL) code is a challenging task on account of the informal nature of natural languages as various syntactic and semantic ambiguities make the process of NL translation to formal languages more complex. However, in our approach the usage of SBVR not only provides natural languages a formal abstract syntax representation but it is also close to OCL syntax. In this thesis, a framework is presented to facilitate the users of the UML tools so that they can write invariants and pre/post conditions in English. The results of the case studies manifest that a natural language based approach to generate OCL constraints can not only help in significantly improving usability of OCL but also outperforms the most closely related techniques in terms of effectiveness and effort required in generating OCL.

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Machado, Luiz Henrique Jorge. "Análise experimental do comportamento dinâmico de mancais radiais hidrodinâmicos de geometria fixa." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/SBPS-7B4P9W.

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Este trabalho apresenta um estudo experimental da influência de mancais radiais hidrodinâmicos cilíndricos e não cilíndricos sobre o comportamento dinâmico de eixos rotativos. Uma bancada de ensaios de rotores horizontais apoiados em dois mancais radiais hidrodinâmicos, capaz de representar diferentes montagens de rotores, é especialmente fabricada para o desenvolvimento desse estudo. Seis mancais hidrodinâmicos de geometria fixa são selecionados para a avaliação da resposta dinâmica de diferentes configurações de rotores. Dois pares de mancais radiais cilíndricos, fabricados por processos de usinagem convencional e por eletro-erosão, e quatro pares de mancais não cilíndricos mancal elítptico (de dois lóbulos ou limão), mancal de dois lóbulos desalinhados (offset), mancal de três lóbulos e mancal de quatro lóbulos fabricados por meio de usinagem de precisão via eletroerosão, são projetados para o sistema de suporte da bancada de rotores desenvolvida nesse trabalho. A análise comparativa do comportamento dinâmico dos seis mancais é efetuada por meio de ensaios de vibrações realizados em condições de velocidade constante e em aceleração. Espectros de freqüência em velocidade zero, espectros de freqüência em diversas velocidades estacionárias de operação, diagramas cascata (waterfall plots) e diagramas das órbitas de precessão do munhão são obtidos a partir da medição das vibrações em diferentes montagens de rotores horizontais suportados pelos mancais selecionados. Acelerômetros e sensores de proximidade sem contato são utilizados para captar os sinais desejados de vibração sobre os mancais sob diferentes condições de carregamento dinâmico. Além dos espectros de freqüência e das órbitas do munhão, a resposta síncrona ao desbalanceamento de diferentes rotores é determinada para cada tipo de mancal para a faixa de velocidades de rotação de 0 a 10.000 rpm. Uma avaliação preliminar do desgaste por contato dos mancais analisados é efetuada por meio de análise metrológica dimensional antes e após os testes de vibração. Os resultados experimentais obtidos permitem a confecção de diversas curvas da resposta dinâmica dos seis mancais analisados, fornecendo subsídios relevantes para a seleção da configuração de mancal radial de geometria fixa mais apropriada para uma dada máquina rotativa. Pela análise comparativa realizada nesse trabalho, a classificação dos mancais analisados baseada na capacidade de atenuar a resposta síncrona ao desbalanceamento de rotores horizontais é dada por: 1) mancal de 2 lóbulos desalinhados (mancal offset); 2) mancal de 3 lóbulos; 3) mancal elíptico; 4) mancal circular de pequena folga radial; 5) mancal circular de grande folga radial; 6) mancal de 4 lóbulos.

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Книги з теми "SBVS"

Lyle, James D., ed. SBus. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2942-1.

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SBus handbook. [Mountain View, Calif.]: Sun, 1994.

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Studies, Centre for Bhutan, ред. Skor phug sgrub kyi lo rgyus gser gyi thigs paʼi yang snying: Sbas yul mnaʼ sbis skor phug. Thimphu, Bhutan: Dpal ʼBrug zhib-ʼjug lte-ba, 2011.

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Lyle, James D. SBus: Information, applications, and experience. New York: Springer-Verlag, 1992.

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Pangsong, Sŏul. SBS-yŏnsa. Sŏul Tʻŭkpyŏlsi: SBS, 2001.

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Pangsong, Sŏul. SBS sŭt'ori. Sŏul-si: SBS, 2010.

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A, Shepelev V., and Vlasov A. V, eds. Sistemnai͡a︡ sreda SAPR SBIS. Moskva: "Nauka", 1994.

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Frank, Edward H. SBus specification B.0. Mountain View, Calif: Sun Microsystems, 1990.

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EINSPRUCH, Norman G. Elektronika SBIS: Proektirovanie mikrostruktur. Moskva: Mir, 1989.

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Rje btsun Pra-dzñā-sa-ra mchog gi srid źiʼi legs tshogs ʼod rgur ʼjo baʼi mdzad ʼphrin daṅ Rdo-sbis grwa tshaṅ gi gdan rabs dad gsum nor buʼi chun po. Pe-cin: Mi rigs dpe skrun khaṅ, 1998.

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Частини книг з теми "SBVS"

Kanagachidambaresan, G. R. "Programming SBCs." In Internet of Things Using Single Board Computers, 75–162. Berkeley, CA: Apress, 2022. http://dx.doi.org/10.1007/978-1-4842-8108-6_3.

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Gooch, Jan W. "SBS." In Encyclopedic Dictionary of Polymers, 646. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_10311.

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Mehlhorn, Heinz. "SBV." In Encyclopedia of Parasitology, 2439. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_5002.

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Mehlhorn, Heinz. "SBV." In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_5002-1.

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Fischer, R. X., and W. H. Baur. "SBS." In Zeolite-Type Crystal Structures and their Chemistry. Framework Type Codes RON to STI, 172–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-70884-1_16.

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Lyle, James D. "Why the SBus?" In SBus, 1–13. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2942-1_1.

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Lyle, James D. "Contrasts with Other Buses." In SBus, 15–38. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2942-1_2.

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Lyle, James D. "Hardware Concepts." In SBus, 39–110. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2942-1_3.

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Lyle, James D. "Firmware Concepts." In SBus, 111–37. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2942-1_4.

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Lyle, James D. "Pitfalls to Avoid." In SBus, 139–88. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2942-1_5.

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Тези доповідей конференцій з теми "SBVS"

Almeida Filho, João L. de, and Jorge H. Fernandez. "HTP SurflexDock: a web tool for Structure-Based Virtual Screening analysis based on the Ensemble Docking protocol." In Brazilian e-Science Workshop. Sociedade Brasileira de Computação - SBC, 2022. http://dx.doi.org/10.5753/bresci.2022.223295.

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Structure-Based Virtual Screening (SVBS) is a technique traditionally used to find a set of specific inhibitors for a receptor structure during the preliminary stages of drug discovery studies. However, more than 90% of SBVS best ranks compounds do not have the expected biological effect at the end of the process. In this context, strategies to increase the success rate must be employed to ensure the experiment's success. Here, we introduce the HTP SurflexDock, a tool that improves the success rate of SBVS experiments through two strategies: First, the ensemble docking protocol enables the simulation of the implicit flexibility of the receptor structure. Second, a post-processing steps allows the user to rescore promising compounds by expanding the conformational space search or estimating the binding free energy through the MM/PBSA protocol. HTP SurflexDock is useful when dealing with flexible receptors and when structural information about the receptor contact area is insufficient or optimized for a specific ligand type. HTP SurflexDock is freely available as a web service or may be downloaded at https://htpsurflexdock.biocomp.uenf.br/.

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Musham, Prakash, Sharad Singh, Rashi Bahal, and Prabhakar TV. "Visual SBVR." In 2008 Third International Conference on Digital Information Management (ICDIM). IEEE, 2008. http://dx.doi.org/10.1109/icdim.2008.4746768.

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Mabilleau, M., D. Salos, C. Rodriguez, H. Secretan, and N. Suard. "SBAS DSVP: An SBAS DFMC Service Volume Software Prototype." In 29th International Technical Meeting of The Satellite Division of the Institute of Navigation (ION GNSS+ 2016). Institute of Navigation, 2016. http://dx.doi.org/10.33012/2016.14738.

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O’Hanlon, Brady, Joseph J. Rushanan, Christopher Hegarty, Jason Anderson, Todd Walter, and Sherman Lo. "SBAS Signal Authentication." In 35th International Technical Meeting of the Satellite Division of The Institute of Navigation (ION GNSS+ 2022). Institute of Navigation, 2022. http://dx.doi.org/10.33012/2022.18443.

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Grant, Alan, George Shaw, Jan �af�r, and Nick Ward. "SBAS use in Maritime." In 29th International Technical Meeting of The Satellite Division of the Institute of Navigation (ION GNSS+ 2016). Institute of Navigation, 2016. http://dx.doi.org/10.33012/2016.14601.

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Majhi, Priyabrata, Harsh K. Kapadia, Alpesh I. Patel, Jayesh J. Barve, and Divyesh R. Raninga. "SBHS: Some control investigations." In 2015 5th Nirma University International Conference on Engineering (NUiCONE). IEEE, 2015. http://dx.doi.org/10.1109/nuicone.2015.7449600.

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Mabilleau, Mikael, Ricardo De Sousa, Joseph Dennis, Richard Farnworth, Philippe Estival, Francisco Salabert, and Daniel Salos. "DFMC SBAS Approach Concept." In 34th International Technical Meeting of the Satellite Division of The Institute of Navigation (ION GNSS+ 2021). Institute of Navigation, 2021. http://dx.doi.org/10.33012/2021.18048.

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Xie, H. A., K. E. Forward, K. M. Adams, and D. Leask. "An SBus monitor board." In the 1995 ACM third international symposium. New York, New York, USA: ACM Press, 1995. http://dx.doi.org/10.1145/201310.201335.

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Xie, H. A., K. E. Forward, K. M. Adams, and D. Leask. "An SBus Monitor Board." In Third International ACM Symposium on Field-Programmable Gate Arrays. IEEE, 1995. http://dx.doi.org/10.1109/fpga.1995.242150.

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Umezawa, H., and S. Shikata. "High-Temperature Diamond SBDs." In 2009 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2009. http://dx.doi.org/10.7567/ssdm.2009.h-6-4.

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Звіти організацій з теми "SBVS"

Morris, C. L., J. M. Anaya, and V. Armijo. Neutron metrology for SBSS. Office of Scientific and Technical Information (OSTI), December 1998. http://dx.doi.org/10.2172/348912.

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Morris, C. L., V. Armijo, J. J. Gomez, G. W. Hart, D. M. Lee, J. D. Zumbro, C. Espinosa, et al. Neutron metrology for SBSS. Office of Scientific and Technical Information (OSTI), January 1998. http://dx.doi.org/10.2172/758826.

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McGill, Sean, Eve Eisemann, and Rose Dopsovic. Sediment Budget Analysis System (SBAS) 2020 user's guide : Version 1.0. Engineer Research and Development Center (U.S.), May 2022. http://dx.doi.org/10.21079/11681/44140.

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This special report acts as a user’s guide for the Sediment Budget Analysis System (SBAS) toolbox within ArcGIS Pro. The SBAS toolbox is a free toolset that allows the user to create and visualize a sediment budget using ArcGIS Pro. Included in this report are instructions on how to download the toolbox and create a sediment budget.

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Mink, Alan, George G. Nacht, and John K. Antonishek. Operating principles of the Sbus MultiKron interface board. Gaithersburg, MD: National Institute of Standards and Technology, 1995. http://dx.doi.org/10.6028/nist.ir.5652.

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Funderburk, Brianna, and Lucas J. Misera. The Impact of Natural Disasters on Small Businesses. Federal Reserve Bank of Cleveland, November 2022. http://dx.doi.org/10.55350/sbcs-20221115.

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The 2021 Small Business Credit Survey (SBCS) found that 1 in 10 small employer businesses suffered losses from a natural disaster during the prior 12 months. According to the National Centers for Environmental Information, the United States experienced 20 billion-dollar natural disasters in 2021, making it one of the costliest years in recent history. Major events included Hurricane Ida, the historic cold wave in Texas and other southern states, and the destructive wildfire season in the West. To more deeply explore the impact of these and other natural disasters on small businesses, the SBCS includes a module of natural disaster-related questions for affected firms. This fact sheet outlines some of the major findings from the 2021 SBCS for employer firms with respect to natural disaster impact.

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Zmuda, Michael W. Stimulated Brillouin Scattering (SBS) Suppression Techniques. Fort Belvoir, VA: Defense Technical Information Center, July 2007. http://dx.doi.org/10.21236/ada473393.

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Salsbury, Timothy. Smart Building Start (SBS) - CRADA 480. Office of Scientific and Technical Information (OSTI), February 2021. http://dx.doi.org/10.2172/1827794.

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Ashcroft, John. Technical assistance on the application of risk-based pension fund supervision by the Superintendencia de Banca, Seguros y AFP (SBS) of Peru. Inter-American Development Bank, February 2017. http://dx.doi.org/10.18235/0003866.

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This document is the eleventh of the PLAC Network Technical Assistance Document Series and is entitled “Technical assistance on the application of risk-based pension fund supervision by the Superintendencia de Banca, Seguros y AFP (SBS) of Peru”. It sets out the conclusions and recommendations arising from an evaluation of the implementation by SBS of risk-based supervision of pensions in February 2018. It builds on an initial evaluation undertaken on materials sent in advance. SBS is an integrated supervisor and regulator of financial services institutions in Peru, and the subject of this review was the Deputy Superintendence for the Supervision of Pension Fund Management Companies.

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Naulleau, Patrick. SBV: Characterization of Highly Reflective EUV Coatings (CRADA AWD00002394). Office of Scientific and Technical Information (OSTI), March 2020. http://dx.doi.org/10.2172/1603672.

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Wiersch, AnnMarie, Barbara J. Lipman, Kim Wilson, and Lucas J. Misera. Clicking for Credit: Experiences of Online Lender Applicants from the Small Business Credit Survey. Federal Reserve Bank of Cleveland, August 2022. http://dx.doi.org/10.26509/frbc-cd-20220816.

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This report presents findings on the experiences of small businesses seeking credit from online lenders, based on data from the 2021 Small Business Credit Survey (SBCS). According to findings, firms that apply to online lenders are more likely to be newer and have fewer employees, lower revenues, and weaker credit scores. In addition, Black- and Hispanic-owned firms are more likely than white- and Asian-owned firms to report that they applied to an online lender. Furthermore, contrary to prior SBCS findings, online-lender applicants were less likely than bank applicants to be approved for the full amount of financing they sought. Generally, online-lender applicants reported lower overall satisfaction with their lenders than did bank applicants. Overall, approved applicants cited fewer challenges with their lender experiences than did applicants that were denied. The only exception was at online lenders, where approved applicants were more likely than denied applicants to cite challenges with high interest rates and unfavorable repayment terms.

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