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Дисертації з теми "Screening natural products"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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1

Kanyanda, Stonard Sofiel Elisa. "Screening of natural products and Alkylating agents for Antineoplastic Activity." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6433_1363357514.

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<p>Background and objectives: Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli however, exogenous factors can induce apoptosis. Many anti-cancer drugs work by activating apoptosis in cancer cells. Natural substances have been found to have the ability to induce apoptosis in various tumour cells and these substances have been used as templates for the construction of&nbsp<br>novel lead compounds in anticancer treatment. On the other hand, alkylating

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2

Hanekom, Thea. "Screening bacterial symbionts of marine invertebrates for ribosomally synthesized natural products." University of the Western Cape, 2016. http://hdl.handle.net/11394/5441.

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>Magister Scientiae - MSc<br>Pharmaceutical research and development strategies rely on the constant discovery of novel natural products as potential drugs. Recent studies have shown that the microorganisms associated with sponges are the true producers of some previously isolated compounds. This study created a large collection of bacterial symbionts associated with the South African marine sponge, Hamacantha esperioides. The bioactivity assays performed, showed that 44 isolates produced compounds with antimicrobial or anti-inflammatory activity. The successful identification of novel s

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3

Demers, Danielle H. "Chemical Investigations of Fungal Natural Products for Drug Discovery." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6825.

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Natural products have, historically, played an important role in drug discovery. Nevertheless, drug resistance, pathogen evolution, and global climate change threaten human health and nearly all current anti-infective treatments on the market today. It is undeniable that new drug discovery efforts are needed with increasing urgency. Bolstered by a rich history of discovering treatments in the world around us, natural products chemists continue to look to the environment with increasing understanding and emerging technologies that allow efficient, effective isolation of new chemical entities. T

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4

Kumar, Rohitesh. "Design and Synthesis of Natural Product-Based Screening Libraries." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/366694.

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Natural products (NPs) continue to have significant impact in the area of drug discovery and development. More than 50% of the approved drugs between 1981 and 2014 were either unaltered NPs, NP derivatives or synthetic drugs inspired by NP pharmacophores. NPs have also served as lead molecules in drug development programs; noteworthy example include the semi-synthetic antifungal drugs caspofungin, anidulafungin, and micafungin that were based on NP lead compounds isolated from the fermentation products of various fungus. Other notable examples include the sponge metabolite halichondrin B that

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5

Pham, Minh Quan. "Bio-pharmacological screening on liver-protective and anti-hepatocarcinoma activities of Vietnam natural products." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30042/document.

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Le carcinome hépatocellulaire (HCC) est le cancer du foie le plus répandu et représente la seconde cause de décès par cancer dans le monde. Un mauvais pronostic et l'absence de traitement efficace en font un problème majeur de santé publique dans les pays en voie de développement, notamment en Asie du Sud-Est, justifiant pleinement la recherche de molécules ou d'approches thérapeutiques nouvelles contre l'HCC. Ce travail porte sur la recherche de molécules isolées de plantes vietnamiennes actives contre l'HCC. La première approche a consisté en un criblage pharmacologique de 33 substances natu

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6

Nolte, Johannes Christoph [Verfasser]. "Screening and characterization of biocatalysts for the glycosylation of natural products / Johannes Christoph Nolte." München : Verlag Dr. Hut, 2020. http://d-nb.info/1219475130/34.

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7

Hoffmann, Thomas [Verfasser], and Rolf [Akademischer Betreuer] Müller. "Screening for myxobacterial natural products : new structures, biosynthesis, and contributions to a comprehensive screening workflow / Thomas Hoffmann. Betreuer: Rolf Müller." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1054328080/34.

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8

Little, Eden. "Evaluation of bioactive natural products from traditional Chinese medicines against a-synuclein-targeted drug screening." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/398094.

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Parkinson’s Disease belongs to a group of overlapping neurodegenerative disorders called α-Synucleinopathies. Patients are diagnosed by degeneration of dopaminergic neurons and the presence of Lewy bodies within surviving neurons of the Substantia Nigra Pars Compacta. These Lewy bodies are proteinaceous deposits of α-Synuclein. This intrinsically disordered protein pathologically aggregates into toxic oligomers or β-sheet fibril species. Currently there are no known drugs available to treat or reverse the pathogenesis of this disease. Therefore there is an unmet clinical need to find small mol

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9

Tran, Thi Minh Tam. "Cytological Profiling of Natural Product Scaffolds Libraries for Parkinson’s Disease." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/365943.

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Parkinson’s disease (PD) is a highly debilitating age-related neurodegenerative disorder arising from the prominent loss of dopaminergic nigro-striatal tracts. It affects approximately 2% of the population over 65 years of age. The majority of cases of PD arise from complex interactions between a myriad of risk-associated genes and environmental risk factors. Due to the intricate combination of multiple factors, efforts towards designing therapies for PD have demonstrated limited efficacy. Current drugs mainly relieve symptoms rather than retarding or modifying disease progression. Natural pro

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10

Essack, Magbubah. "Screening extracts of indigenous South African plants for the presence of anti-cancer compounds." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_8767_1210844967.

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<p>Early man dabbled with the use of plant extracts to cure ailments. This practice has been passed down from generation to generation and today more than 50% of the world'sdrugs are natural products or derivatives thereof. Scientists have thus established a branch of research called natural product research. This branch of research involves the identification and purification of secondary metabolites with a specific biological activity. The methodology involves the screening of plant products for a specific biological activity, purification of the biologically active natural product by separa

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11

Noguchi, Taro. "Development of a Screening Process from Virtual Mirror-image Library of Natural Products Using D-Protein Technology." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225537.

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12

Napagoda, Mayuri Tharanga [Verfasser], Georg [Akademischer Betreuer] Pohnert, Aleš [Akademischer Betreuer] Svatoš, and Wolfram [Akademischer Betreuer] Weckwerth. "Metabolomics for natural products : fast screening and discovery / Mayuri Tharanga Napagoda. Gutachter: Georg Pohnert ; Aleš Svatoš ; Wolfram Weckwerth." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/1060717247/34.

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13

Heinke, Ramona Verfasser], Ludger [Akademischer Betreuer] Wessjohann, and Uwe [Akademischer Betreuer] [Karst. "Mass spectrometry, biological screening and informatics of prenylated natural products : [kumulative Dissertation] / Ramona Heinke. Betreuer: Ludger Wessjohann ; Uwe Karst." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015. http://d-nb.info/1077768168/34.

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14

Ortlieb, Nico Verfasser], and Timo H. J. [Akademischer Betreuer] [Niedermeyer. "Characterization of Natural Products from Actinobacteria of the Tübingen Strain Collection – Screening, Isolation & Structure Elucidation / Nico Ortlieb ; Betreuer: Timo Niedermeyer." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1190639777/34.

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15

Ortlieb, Nico [Verfasser], and Timo H. J. [Akademischer Betreuer] Niedermeyer. "Characterization of Natural Products from Actinobacteria of the Tübingen Strain Collection – Screening, Isolation & Structure Elucidation / Nico Ortlieb ; Betreuer: Timo Niedermeyer." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1190639777/34.

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16

Ghafoory, Shima. "Development of a screening assay for inhibitors of inflammation useful against pancreatic cancer." Thesis, Mälardalen University, Mälardalen University, School of Sustainable Development of Society and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-7797.

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<p>Pancreatic cancer is the fourth most lethal cancer and ranks as the eighth most commonly diagnosed cancer worldwide. This is due to its rapid proliferation, strong metastatic potential and its delayed detection. One major risk factor for developing pancreatic cancer is the aggressive inflammatory disease chronic pancreatitis. Chronic inflammation frequently precedes the development of certain pancreatic cancers.</p><p>Inflammation is a protective and necessary process by which the body can alert the immune system of the existence of a wound or infection and mount an immune response to remov

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17

Saunders-Mattingly, Meredith A. "DISCOVERY OF NATURAL PRODUCT ANALOGS AGAINST ETHANOL-INDUCED CYTOTOXICITY IN HIPPOCAMPAL SLICE CULTURES." UKnowledge, 2018. https://uknowledge.uky.edu/psychology_etds/142.

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An estimated 13.9% of Americans currently meet criteria for an alcohol (ethanol; EtOH) use disorder (AUD). While there are 4 medications approved by the Food and Drug Administration (FDA) to treat AUD, these treatments have demonstrated poor clinical efficacy. Our ongoing research program encompasses a multi-tiered screening of a natural product library and validation process to provide novel information about the mechanisms underlying EtOH-induced changes in neurobiology and to identify novel chemical scaffolds to be exploited in the development of pharmacological treatments for AUD in a rode

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18

Viscardi, Ariel. "Avaliação da atividade antiproliferativa de extratos hidroalcoólicos de plantas em linhagens celulares humanas de câncer de mama, fígado e próstata." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-29082018-140818/.

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O câncer é uma das doenças que mais acometem a população no mundo. Dessa forma, estudar suas terapêuticas é importante para o entendimento dos mecanismos e alvos biológicos por detrás da doença. Apesar dos tratamentos convencionais apresentarem uma boa eficácia, eles também provocam respostas indesejadas, como danos moleculares, resistência de células neoplásicas e efeitos colaterais fortes, colaborando para uma maior taxa de reincidência de neoplasias e mortalidade de pacientes. Sendo assim, a busca por alternativas é um importante desafio da Ciência Moderna para aprimorar e/ou substituir ess

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19

Schuhmann, Imelda. "Aufbau einer HPLC-UV-ESI-MS-MS-Datenbank und ihre Anwendung im Screening arktischer und antarktischer Meeresbakterien." Doctoral thesis, [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=977037568.

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20

Barnes, Emma Catherine. "Chemical Diversity of Eremophila Species and Screening Library Generation." Thesis, Griffith University, 2012. http://hdl.handle.net/10072/366931.

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This thesis explores two aspects of natural product (NP) chemistry. In part A, the use of NPs as scaffolds in the generation of screening libraries was explored as a valuable way to produce structurally diverse compounds with lead- or drug-like physicochemical parameters. Part B describes the chemical investigations of several species from the under-studied Australian endemic plant genus Eremophila, which was selected for examination as it had high potential to be a source of both new chemistry and of unique scaffolds for screening library production.<br>Thesis (PhD Doctorate)<br>Doctor of Phi

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21

Egbewande, Folake. "Use of Natural Product Scaffolds in the Generation of Screening Libraries for Drug Discovery." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/380986.

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Natural products (NPs) have been a major source of chemical and structural diversity that has been a driving force for drug discovery over the past century. NPs have displayed a significant and vast range of biological activities, providing therapeutic agents in the areas of oncology, inflammation, infectious diseases, hypercholesteremia and tissue rejection in organ transplantation, to name a few. Many drugs on the market are of NP origin, either as unmodified or modified NPs. In 2016, it was reported that approximately 50% of new chemical entities approved between 1981 and 2014 were of NP or

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22

Scaduto, Ryan. "A Natural Product and High-Throughput Screening Synthetic Approach Towards the Discovery of Antileishmanial Agents." Ohio Dominican University Honors Theses / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1620081955401195.

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23

Vu, Hoan. "Bioaffinity Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Direct Screening of Natural Product Extracts." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/367940.

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The search for new drugs in natural products involves the screening of natural product extracts on therapeutic targets for the presence of active compounds and subsequent investigation of their biological activities. Towards this end, a rapid and effective strategy to identify the noncovalent interactions between active ligands from natural product extracts with therapeutic protein targets without false positive or negative results is critical. The current thesis presents the outcomes of research exploring a novel approach of biological screening of natural product extracts using bioaffinity E

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24

Premnath, Priyanka Verfasser], and Irene [Akademischer Betreuer] [Wagner-Döbler. "Weakening the enemy: Novel whole cell reporter for natural product screening / Priyanka Premnath ; Betreuer: Irene Wagner-Döbler." Braunschweig : Technische Universität Braunschweig, 2017. http://d-nb.info/1175890405/34.

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25

Al, Ibrahim Malak. "Anti-coronavirus potential of halophytes and invasive plants from Northern France : discovery of active terpenoids from Hippophae rhamnoides and Senecio inaequidens." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS003.

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Les coronavirus sont responsables de maladies des voies respiratoires bénignes à graves chez l’Homme. Malgré des progrès significatifs dans la compréhension de la pathologie et de la gestion clinique des coronavirus, ces maladies virales restent un problème de santé publique en raison d’épidémies récurrentes provoquées par l’émergence de variants, d’un accès inégal aux traitements contre la COVID-19, de taux de vaccination inadéquats et de populations à haut risque non vaccinées. Il est donc impératif de développer des solutions antivirales spécifiques et abordables pour contrôler et prévenir

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26

Hoffmann, Michael [Verfasser], and Rolf [Akademischer Betreuer] Müller. "Mass spectrometry in natural product research: deciphering microbial biosyntheses and contributions to a novel screening approach / Michael Hoffmann ; Betreuer: Rolf Müller." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1139252208/34.

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27

Shubbar, Ahmed. "Novel neuroprotective compounds for use in Parkinson's disease." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1384806955.

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28

Naman, Charles Benjamin. "Phytochemical Investigation of the Medicinal Plant Taxodium distichum and Library Screening of Thalictrum Alkaloids for New Antileishmanial Drug Leads." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429283826.

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29

Blondeau, Sylvain. "Développement d'une plateforme informatique hétérogène appliquée à la pharmacognosie." Thesis, Orléans, 2011. http://www.theses.fr/2011ORLE2004.

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La pharmacognosie, science multidisciplinaire étudiant les produits naturels, n'a eu de cesse de s'adapter et d'évoluer parallèlement aux autres disciplines, en particulier les techniques d'analyse chimique et les technologies de l'information. De nouvelles approches complémentaires, comme la pharmacognosie inverse allant des molécules vers les organismes sources, un cheminement en sens inverse de la pharmacognosie, ont été développées. Les données nécessaires à ces études n'ont jamais été aussi nombreuses et hétérogènes. Molécules, activités, cibles, organismes sources et leurs usages traditi

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30

Alcover, Charlotte. "Réseaux moléculaires et Chimie des Substances Naturelles : de l’isolement de composés inédits à de toutes nouvelles applications en synthèse biomimétique." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS569.

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La découverte de nouvelles entités naturelles est un processus particulièrement long et coûteux ; il faut donc réussir le plus tôt possible à détecter les composés connus dans les matrices étudiées, afin de ne pas les ré-isoler inutilement. C’est tout l’enjeu de l’annotation (c’est-à-dire l’identification partielle mais rapide de composés) et de la déréplication (autrement dit, l’application de l’annotation en vue d’écarter les molécules déjà connues du processus d’isolement).Grâce à sa sensibilité inégalée et à l’avènement de l’ère du « big data », la chromatographie liquide à haute performan

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31

Elisa, Kanyanda Stonard Sofiel. "Screening of natural products and alkylating agents for antineoplastic activity." Thesis, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6466_1285872303.

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<p><b><font face="TimesNewRomanPS-BoldMT"> <p align="left">Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli however, exogenous factors can induce apoptosis. Many anti-cancer drugs work by activating apoptosis in cancer cells. Natural substances have been found to have the ability to induce apoptosis in various tumour cells and these substances have been used as templates for the construction of novel lead compounds in anticancer treatment. On the ot

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32

Hsieh, Cheng-Chih, and 謝政智. "Discovery of novel microtubule inhibitors through screening of natural products and rationale design." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/36289022624515747555.

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博士<br>國防醫學院<br>醫學科學研究所<br>100<br>Microtubule is a popular target for anti-cancer drugs. A novel antitubulin compound chamaecypanone C was isolated from the heartwood of Chamaecyparis obtusa var. Formosan. In addition, a series of 4-aroyl- 6,7,8-trimethoxyquinolines antitubulin compounds were synthesized and evaluated for anticancer activity. Chamaecypanone C induces mitotic arrest through binding to the colchicine-binding site of tubulin, thus preventing tubulin polymerization. Cytotoxic activity of Chamaecypanone C in a variety of human tumor cell lines has been ascertained, with IC50 values

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33

Ding, Yu-Ju, and 丁玉如. "Screening of the chemopreventive componds against aristolochic acid-induced nephropathy from natural products." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/56600529645286014673.

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碩士<br>淡江大學<br>生命科學研究所碩士班<br>98<br>Aristolochic acid (AA) occurs naturally in Aristolochiaceae plants, and toxicological studies have shown the role of AA in human aristolochic acid nephropathy (AAN). Most studies have focused on the adult toxicity of AA, but the embryonic toxicity and toxicological mechanisms are still not clear. Therefore, we used zebrafish embryos to investigate the effects of AA on embryonic development and toxicity. After 24-hpf embryos were treated with AA (10 ppm) for 7 hours, the 48-hpf embryo kidney (glomeruli, pronephric tubules, and pronephric ducts) and heart (defor

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34

Hsieh, Fei-Hung, and 謝飛弘. "Screening natural products and drugs for the therapy of autoimmune diseases by efferocytosis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/35ud62.

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WU, WEI-SHEN, and 吳韋伸. "Development of Affinity-Based Screening Platform to Isolate Bacterial Transglycosylase Inhibitors from Natural Products." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/jquha5.

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博士<br>國防醫學院<br>生命科學研究所<br>106<br>The issue of antibiotic resistance has provoked a mounting crisis across the globe. With a lack of new therapeutic agents, there is an undoubted need for human to identify new antibiotics to combat resistant bacterial infections. As part of our efforts to develop new antibiotics to target the uncharted surface bacterial transglycosylase (TGase), we report an affinity-based ligand screening platform equipped with functional penicillin-binding proteins (PBPs) immobilized beads to selectively isolate TGase binders from complex natural products. In combination with

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36

Mnatsakanyan, Mariam. "Natural antioxidants and high performance liquid chromatography (HPLC) hyphenated screening techniques." Thesis, 2010. http://handle.uws.edu.au:8081/1959.7/496789.

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Reactive intermediates in the oxidative processes are among the major sources of primary catalysts that initiate oxidation in vivo and in vitro; a process that is one of the major causes of food quality deterioration and generation of chronic diseases. Antioxidants, both natural and synthetic, have been widely used at legal limits in food, medical and personal care industries. However, recently, the use of synthetic antioxidants has been severely restricted because of the evidence that suggests they may be harmful to human health. As such, the importance of screening naturally occurring altern

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37

GU, FU-MEI, and 古富美. "Screening of bioactive natural products in cordyceps sinensis to inhibit the activating human mesangial cells." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/23067790818127387111.

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碩士<br>國立陽明大學<br>藥理學研究所<br>81<br>IgA 腎炎是由於IgA 免疫複合體沈積於腎間質所誘發的腎絲球病變，為亞洲地區最常見的原發性腎絲球疾病之一。其主要的致病機轉是：原本呈休止狀態的腎間質細胞，經致腎病性IgA 免疫複合體及或其它細胞激素刺激後活化，並釋出各種細胞激素及生長因子，這些細胞激素及生長因子的作用如同自泌素，使腎間質細胞不斷增生，並放出一些化學媒介物，造成間質增生與腎基底膜的傷害，最後導致腎絲球硬化。目前IgA 腎炎無特殊治療藥，大約有20％的病人會繼續惡化進行至腎衰竭，因此尋找IgA 腎炎治療藥為今日十分重要的課題。冬蟲夏草為子囊菌亞群麥角菌科真菌，寄生於鱗翅目幼蟲，是珍貴的傳統中藥材，藥理作用非常廣泛，主要的作用在免疫系統及腎功能方面，其改善腎功能的方式，大部份是由於調節免疫機能。本論文以冬蟲夏草為研究對象，並以「抑制體外培養之活化的人類腎間質細胞增生」及「抑制體內誘發鼷鼠發生Ig

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Riyaphan, Jirawat, та Jirawat Riyaphan. "Virtual Screening of Natural Compounds or Products against α-glucosidase and α-amylase Activities for Lowering Blood Glucose". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ebg5t5.

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博士<br>國立東華大學<br>生命科學系<br>107<br>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder in which the prevalence has been increasing steadily in worldwide. As a result, it is widespread rapidly caused by the gene, extra weight, and metabolism syndrome. The inhibition of α-glucosidase and α-amylase is an alternatively clinical treatment to delay the absorption of glucose in controlling hyperglycemia. The seeking new drugs from small molecules or natural compounds via virtual screening is crucial because the composition from some natural sources whether are targeted to the α-glucosidase a

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Hsu, Yu-Fen, and 許毓芬. "Screening of bioactive natural products from cordyceps sinensis for the anti-platelet activation factor in the treatment of asthma." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/12158345686067193092.

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Mhd, Bakri Yuhanis. "Studies in marine natural products: 1. dynamin 1 screening of sponges from Catherine Hill Bay 2. chemistry of Cystophora xiphocarpa 3. investigation of “paua greening” of Haliotis iris from New Zealand’s Cook Strait." Thesis, 2015. http://hdl.handle.net/1959.13/1295874.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Crudely partitioned extracts of nine sponge samples from Catherine Hill Bay, NSW, Australia, were screened for dynamin 1 bioactivity. Dynamin 1 is an enzyme that is essential for clathrin coated vesicle formation in endocytosis and has been linked to many neurological disease for example amyotrophic lateral sclerosis (ALS) and Alzheimer. At 1 mg / mL, the methanol extract of sponge YMB080612CB01 showed the strongest inhibition, i.e. lowest dynamin 1 activity (5%), among all tested samples. Bioassay-guided isolation of these extracted fractions

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Hajjar, Dina A. "Bio-prospecting of Plants and Marine Organisms in Saudi Arabia for New Potential Bioactivity." Diss., 2016. http://hdl.handle.net/10754/621995.

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The natural resources offer a unique opportunity for the discovery of active compounds, due to the complexity and biodiversity of their chemical structures. Natural resources have been used as medicines throughout human history. Saudi Arabia’s natural resources, for instance its terrestrial medicinal plants and the Red Sea sponges, have not been extensively investigated with regard to their biological activities. To better identify the diversity of compounds with bioactive potential, new techniques are also necessary in order to improve the drug discovery path. This study comprises three sect

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Kjer, Julia [Verfasser]. "New natural products from endophytic fungi from mangrove plants : structure elucidation and biological screening = Neue Naturstoffe aus endophytischen Pilzen aus Mangroven / vorgelegt von Julia Kjer." 2009. http://d-nb.info/1011391422/34.

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Ströch, Karsten. "Chemisches Screening von ausgewählten Actinomyceten sowie Strukturaufklärung von Sekundärmetaboliten aus Micromonospora sp. und Pflanzen." Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-B0A2-9.

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Schuhmann, Tim. "Untersuchungen zur Biosynthese und Aktivität ausgewählter Plecomakrolide sowie chemisches Screening von Actinomyceten." Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-AE9C-8.

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Bitzer, Jens. "Isolierung und Strukturaufklärung neuer Naturstoffe aus Bakterien und endophytischen Pilzen durch chemisches Screening." Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-AD48-A.

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Hoffmann, Luise. "Struktur und Biosynthese von Collinolacton aus Streptomyces sp. und Beiträge zum Screening neuer Wirkstoffe." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-AEA6-0.

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Jacques, Samuel. "Generation and screening of natural product-like compounds for antibiotic discovery." Thesis, 2016. http://hdl.handle.net/1866/16243.

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Avec l’apparition de plus en plus de souches de bactérie résistante aux antibiotiques, le développement de nouveaux antibiotiques est devenu une important problématique pour les agences de santé. C’est pour cela que la création de nouvelles plateformes pour accélérer la découverte de médicaments est devenu un besoin urgent. Dans les dernières décennies, la recherche était principalement orientée sur la modification de molécules préexistantes, la méta-analyse d’organismes produisant des molécules activent et l’analyse de librairies moléculaires pour trouver des molécules synthétiques activent,

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Wolff, Diana. "Allene, Dihydronaphthalenon-Derivate und andere Sekundärmetabolite aus Pilzen mariner Habitate sowie Beiträge zu deren Biosynthese." Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-B0AB-8.

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Schlörke, Oliver. "Isolierung, Strukturaufklärung und Biosynthese von Sekundärmetaboliten endophytischer Pilze aus Algen und Pflanzen mariner Habitate." Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-B0AF-F.

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Radzom, Markus. "Beiträge zur Biosynthese der antiparasitären Naturstoffe Hormaomycin und Borrelidin sowie Strukturaufklärung von Sekundärmetaboliten aus Actinomyceten." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-AC88-2.

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