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Готові списки джерел за темами / Serotonin (5-HT) receptors

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Добірка наукової літератури з теми "Serotonin (5-HT) receptors"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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Статті в журналах з теми "Serotonin (5-HT) receptors"

1

Neumann, Joachim, Britt Hofmann, Stefan Dhein, and Ulrich Gergs. "Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease." International Journal of Molecular Sciences 24, no. 5 (2023): 4765. http://dx.doi.org/10.3390/ijms24054765.

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Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as well as arrhythmias, in the human heart. In addition, 5-HT4-receptors may play a role in sepsis, ischaemia, and reperfusion. These presumptive effects of 5-HT4-receptors are the focus of the present review. We also discuss the formation and inactivation of serotonin in the body, namely, in the heart. We identify cardiovascular diseases where serotonin might play a causative or additional role. We address th

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2

Saxena, Pramod R., and Michel D. Ferrari. "From Serotonin Receptor Classification to the Antimigraine Drug Sumatriptan." Cephalalgia 12, no. 4 (1992): 187–96. http://dx.doi.org/10.1046/j.1468-2982.1992.1204187.x.

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After the synthetic serotonin 5-hydroxytryptamine (5-HT) became available in the early 1950s, attempts were soon under way to study the nature of 5-HT receptors. Using the guinea-pig isolated ileum, Gaddum and Picarelli (1957) suggested that 5-HT-induced contractions were mediated by a morphine-sensitive “M” receptor located on the parasympathetic ganglion and a dibenzyline-sensitive “D” receptor located on the smooth muscle. Though this classification was used during the next three decades, it was realized that some effects of serotonin, for example vasoconstriction within the carotid vascula

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3

Lychkova, Alla Eduard. "Serotonin Receptors Mediate Contractile Activity of Rat's Esophagus in-vivo." Archive of Organ Transplantation 2, no. 1 (2017): 019–22. https://doi.org/10.17352/aot.000007.

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<strong>Background: </strong>Serotonin (5-hydroxytryptamine, 5-HT) is a regulatory and biologically active neurotransmitter and a hormone in the CNS and many organs, including the esophagus. It is known that serotonin as well as acetylcholine stimulates contractile activity of the esophageal muscles. However, role of different serotonin receptors in the 5-HT contractile activity of the esophagus is insufficiently known.

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4

Amidfar, Meysam, and Yong-Ku Kim. "Recent Developments on Future Antidepressant-related Serotonin Receptors." Current Pharmaceutical Design 24, no. 22 (2018): 2541–48. http://dx.doi.org/10.2174/1381612824666180803111240.

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Conventional serotonin-enhancing antidepressants including selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) have shown effectiveness in the treatment of major depression, but their significant limitations such as slowness of action have led to intensive research efforts to develop new antidepressants. Increased synaptic neurotransmission of serotonin (5-hdroxytryptamine; 5-HT) through orchestration of stimulation and blockade of various subtypes of 5-HT receptors is involved in the mechanisms of action of SSRIs. Agonists at the 5-HT1A

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5

Cowen, P. J. "Serotonin Receptor Subtypes: Implications for Psychopharmacology." British Journal of Psychiatry 159, S12 (1991): 7–14. http://dx.doi.org/10.1192/s0007125000296190.

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Serotonin (5-HT) interacts with multiple brain 5-HT receptor subtypes to influence a wide range of behaviours. Three main families of 5-HT receptors (5-HT1, 5-HT2 and 5-HT3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms, and the behavioural processes they regulate. Nevertheless, manipulation of several different 5-HT receptor subtypes (5-HT1A, 5-HT1c, 5-HT2 and 5-HT3) may produce anxiolytic effects; 5-HT1A and 5-HT2 receptors may be involved in the aetiology of major depression and the therapeutic effects of antide

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6

Kostowski, W. "Ethanol and serotonin 5-HT-5 receptors." Pharmacological Research 31 (January 1995): 36. http://dx.doi.org/10.1016/1043-6618(95)86402-4.

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7

Schmitz, Dietmar, Tengis Gloveli, Ruth M. Empson, and Uwe Heinemann. "Serotonin Reduces Polysynaptic Inhibition via 5-HT1A Receptors in the Superficial Entorhinal Cortex." Journal of Neurophysiology 80, no. 3 (1998): 1116–21. http://dx.doi.org/10.1152/jn.1998.80.3.1116.

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Schmitz, Dietmar, Tengis Gloveli, Ruth M. Empson, and Uwe Heinemann. Serotonin reduces polysynaptic inhibition via 5-HT1A receptors in the superficial entorhinal cortex. J. Neurophysiol. 80: 1116–1121, 1998. The superficial cells of the entorhinal cortex (EC), main input to the hippocampus, receive a serotonergic input from the raphe nuclei and express 5-hydroxytryptamine creatine sulfate complex (5-HT) receptors at high density. With the use of intracellular recordings, we investigated the effects of serotonin on synaptic inhibition of layer II and III neurons of the EC. Serotonin reduced bot

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8

Puzikov, A. M. "Esophagus: serotoninerdgic regulation." Experimental and Clinical Gastroenterology, no. 7 (September 27, 2020): 137–42. http://dx.doi.org/10.31146/1682-8658-ecg-179-7-137-142.

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Introduction: Serotonin (5-hydroxytryptamine, 5-HT) is a regulatory neurotransmitter and a hormone in the CNS and hole organs, the esophagus including. It is known that serotonin, activating its own receptors, stimulates contractile activity of the esophageal muscles. However, role of different type receptors in the 5-HT induced contractile activity of the esophagus is insufficiently known.The aim: — to determine which type of 5-HT receptors mediate serotonin dependent contractile activity of the esophagus.Material and methods: This is a electromyography study of rat esophagus contractile acti

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9

Frieling, T., H. J. Cooke, and J. D. Wood. "Serotonin receptors on submucous neurons in guinea pig colon." American Journal of Physiology-Gastrointestinal and Liver Physiology 261, no. 6 (1991): G1017—G1023. http://dx.doi.org/10.1152/ajpgi.1991.261.6.g1017.

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Intracellular microelectrodes were used to investigate the neuropharmacology of 5-hydroxytryptamine (5-HT) in the submucous plexus of the distal colon of the guinea pig. Three effects resulted from application of 5-HT to submucous neurons. Two of the effects were components of a biphasic depolarization mediated by receptors on the neuronal cell body. The third was suppression of acetylcholine release at nicotinic synapses on the cell bodies and was mediated by presynaptic 5-HT receptors. The initial component of the biphasic depolarization was a rapidly activating response characterized by inc

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10

Cheng, Yuan Shan, Yuan Sheng Liu, Godfrey ChiFung Chan, Jie Yu Ye, Yu Lung Lau, and Mo Yang. "Effects of Serotonin on Proplatelet Formation and F-actin Reorganization in Human Megakaryocytes." Blood 110, no. 11 (2007): 2108. http://dx.doi.org/10.1182/blood.v110.11.2108.2108.

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Abstract We previously reported that serotonin (5-HT) is a growth factor for hematopoietic stem cells and megakaryocytic progenitor (Yang et al, Stem Cells, 2007). We further proposed a possible role of serotonin on megakaryocyte differentiation and platelet formation. The effect of serotonin on proplatelet formation and F-actin reorganization in human megakaryocytes (MKs) was investigated in this study. Our results showed that: There was a stimulating effect of serotonin on proplatelet formation in human bone marrow megakaryocytes. Human BM MK progenitors cultured in serum free medium with ei

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Дисертації з теми "Serotonin (5-HT) receptors"

1

Quérée, Philip. "Feedback control in the central 5-HT system : evidence for a role of 5-HT₂c receptors." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670061.

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2

Liwicki, Gemma Michele. "The design and synthesis of 5-HT₁B receptor antagonists." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608202.

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3

Benjamin, Daniel E. (Daniel Ernest). "The effects of sustained gepirone administration on rodent brain 5-HT receptors and behavioral analogues of anxiety." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798440/.

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Clinical evidence has demonstrated that the anxiolytic effects produced by the selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist, gepirone, increase progressively over one to three weeks of treatment.

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4

Cohen, Zvi. "Central serotonin (5-HT) neurons in the control of the cerebral circulation, anatomical basis and functional receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0003/NQ44387.pdf.

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5

Cohen, Zvi 1967. "Central serotonin (5-HT) neurons in the control of the cerebral circulation : anatomical basis and functional receptors." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37543.

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Serotonin (5-hydroxytryptamine, 5-HT) is known to influence cerebrovascular functions such as local cerebral blood flow (CBF) and blood brain barrier (BBB) permeability, and has been implicated in cerebrovascular diseases. The present study used a multifaceted approach to determine the distribution, density and origin of the 5-HT innervation of blood vessels at the base of the brain and overlying the cerebral cortex as well as those embedded in the cortical parenchyma. In addition, the type(s) of 5-HT receptor(s) present on intracortical blood vessels as well as their precise cellular localiza

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6

Kinoshita, Minako. "Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5." Kyoto University, 2010. http://hdl.handle.net/2433/131915.

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7

Zhou, Zhu. "Exploring the effects of 5-HT2A and AMPA receptors on brain 5-HT via a mechanism-based pharmacodynamic model." Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/143.

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Depression is a common mood disorder. Although major ethical challenges make it nearly impossible to invasively and directly measure serotonin (5-hydroxytryptamine, 5-HT) levels in human brains, neuroimaging technologies have shown macroscopic structural and functional abnormalities in the prefrontal cortex (PFC) of depressed patients. The monoamine hypothesis of depression is based on the neurotransmitter imbalance, such as deceased serotonin brain levels are implicated in the cause of depression. Research has focused on the control mechanisms involved in the dorsal raphé nucleus (DRN) which

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8

Thirumaran, Sangeetha-Laura. "Polypharmacologie des récepteurs mélatoninergiques et sérotoninergiques à visée thérapeutique Structure-activity relationships of serotonin 5-HT 7 receptors ligands: A review." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC406.

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Un des enjeux actuels de santé publique est de proposer de nouvelles stratégies pour le traitement de pathologies neurodégénératives et neuropsychiatriques qui, de part leurs origines multifactorielles, restent difficiles à traiter. Ces dernières décennies ont vu l’émergence d’une nouvelle alternative thérapeutique prometteuse, en vue d’obtenir non seulement une action préventive mais aussi curative : la polypharmacologie. Des effets neuroprotecteurs et pro-cognitifs ont ainsi été mis en évidence in vivo par la modulation simultanée de différentes cibles biologiques impliquées dans la physiopa

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9

Majeed, Zana R. "MODULATORY ACTIONS OF SEROTONERGIC SYSTEM IN CARDIAC FUNCTION, BEHAVIOR, AND SENSORIMOTOR CIRCUIT ACTIVITY IN DROSOPHILA MELANOGASTER." UKnowledge, 2016. http://uknowledge.uky.edu/biology_etds/32.

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In this dissertation, I have focused on the role of serotonin (5-HT) as a modulator in heart rate, feeding and locomotion behaviors as well as sensorimotor circuit activity in Drosophila melanogaster. A general overview in the actions of the serotonergic (5-HTergic) system on the larval heart and nervous system in larvae and adults is reviewed in Chapter One. I sought to further study the actions of serotonergic system to provide additional insights into cellular and molecular underpinnings in the actions of 5-HT.In Chapter two, I present studies on mechanisms of action by 5-HT in larvae cardi

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10

Jouha, Jabrane. "Conception, synthèse et évaluation biologique de nouveaux ligands sérotoninergiques 5-HT₇." Thesis, Orléans, 2017. http://www.theses.fr/2017ORLE2013/document.

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Dès la découverte des récepteurs 5-HT₇ en 1993, des études intenses de relation structure-activité ont été poursuivies par plusieurs groupes de recherches, dont notre laboratoire. En conséquence, un nombre impressionnant de ligands potentiels 5-HT₇ sont référencés dans la littérature mais peu sont des agonistes sélectifs. Dans ce contexte, ce travail de thèse a pour but principal, la conception de quatre classes distinctes de ligands et leur évaluation en tant que ligand agoniste des 5-HT₇R. Dans un premier temps, nous nous sommes intéressés à la préparation de ligands de type 2,4-diaminopyrid

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Книги з теми "Serotonin (5-HT) receptors"

1

Michel, Hamon, ed. Central and peripheral 5-HT₃ receptors. Academic Press, 1992.

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2

T, Dourish Colin, Hutson P, and Ahlenius S, eds. Brain 5-HT[subscript]IA receptors: Behavioural and neurochemical pharmacology. VCH, 1987.

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3

Visser, Willemina Hester. 5-HT₁ receptor agonists in the acute treatment of migraine: Clinical, epidemiological and pharmacological aspects. Eburon, 1996.

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4

Göthert, M., and H. G. Baumgarten. Serotoninergic Neurons and 5-HT Receptors in the CNS. Springer London, Limited, 2012.

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5

Dourish, Colin T., and S. Ahlenius. Brain 5-Ht Receptors, 1A: Behavioural and Neurochemical Pharmacology (Ellis Horwood Series in Biomedicine). Vch Pub, 1988.

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6

Britell, Patrick E., and Charles M. Andrews. Serotonin Toxicity. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0094.

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Serotonin toxicity is a potentially life-threatening and severe illness that results from excess serotonin activity. It can be due to prescription medications, drug interactions, and sometimes intentional poisonings. This illness is often iatrogenic and can be predicted by the amount of excess serotonin (5-HT) that activates serotonin receptors both centrally and peripherally. Serotonin toxicity produces a large range of symptoms and varies in cases from mild to severe and even lethal. This chapter reviews the mechanism of development of this illness, symptoms and criteria for diagnosis, appro

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Частини книг з теми "Serotonin (5-HT) receptors"

1

Kaumann, Alberto J., Ken J. Murray, Anthony M. Brown, James E. Frampton, Louise Sanders, and Morris J. Brown. "Heart 5-HT Receptors. A Novel 5-HT Receptor in Human Atrium." In Serotonin. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-1912-9_45.

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2

Richardson, B. P., G. Engel, P. Donatsch, and K. H. Buchheit. "5-HT Receptors on Afferent Neurones." In Serotonin. Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10114-6_3.

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3

Xia, Zongqi, Douglas J. Sheffler, and Bryan L. Roth. "5-HT Receptor-Associated Proteins (FRAPs)." In The Serotonin Receptors. Humana Press, 2006. http://dx.doi.org/10.1007/978-1-59745-080-5_8.

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4

De Vivo, Michael, and Saul Maayani. "5-HT Receptors Coupled to Adenylate Cyclase." In The Serotonin Receptors. Humana Press, 1988. http://dx.doi.org/10.1007/978-1-4612-4560-5_5.

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5

Sanders-Bush, Elaine. "5-HT Receptors Coupled to Phosphoinositide Hydrolysis." In The Serotonin Receptors. Humana Press, 1988. http://dx.doi.org/10.1007/978-1-4612-4560-5_6.

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6

Davies, Marilyn A., Chiao-ying Chang, and Bryan L. Roth. "Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure." In The Serotonin Receptors. Humana Press, 2006. http://dx.doi.org/10.1007/978-1-59745-080-5_3.

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7

Tricklebank, M. D. "Behavioural Correlates of the Activation of 5-HT Receptors." In Serotonin. Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10114-6_11.

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8

Leff, P., and G. R. Martin. "The Classification of 5-HT Receptors Using Tryptamine Analogues." In Serotonin. Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10114-6_25.

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9

Gershon, M. D., G. M. Mawe, and T. A. Branchek. "Multiple 5-HT Receptors in the Enteric Nervous System." In Serotonin. Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10114-6_5.

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10

Mengod, Guadalupe, M. Teresa Vilaró, Roser Cortés, Juan F. López-Giménez, Andreu Raurich, and José M. Palacios. "Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain." In The Serotonin Receptors. Humana Press, 2006. http://dx.doi.org/10.1007/978-1-59745-080-5_10.

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Тези доповідей конференцій з теми "Serotonin (5-HT) receptors"

1

Demolle, D., E. J. Cragoe, and J. M. Boeynaems. "MECHANISMS INVOLVED IN 5-HT STIMULATION OF PROSTACYCLIN PRODUCTION BY BOVINE AORTIC SMOOTH MUSCLE CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642841.

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Serotonin (5-HT) stimulates prostacyclin (PGI2) production by bovine aortic smooth muscle cells in culture via 5-HT2 receptors (1). These cells express a synthetic phenotype (2), whereas the majority of the smooth muscle cells in the media from adult arteries are in a contractile state. We have now shown that 5-HT (1-10 μM) also stimulates PGI2 production by a preparation of contractile smooth muscle cells : explants from bovine aortic media cultured for short periods. This effect is independent from 5-HT2 receptors : it is only partially inhibited (±30%) by ketan-serin (a selective and potent

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2

Simakajornboon, N., P. Apiwattanasawee, M. McClellan та E. Olsen. "The Effect of Prenatal Nicotine Exposure on Interaction between PDGF-β Receptor (PDGFR) and Serotonin (5-HT) Receptors in the Caudal Brainstem (CB) of Developing Mice." У American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6339.

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3

De Crée, J., H. Geukens, H. Demoen, and H. Verhaegen. "HEM0RRHE0L0GY AND KETANSERIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644212.

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Red blood cell (RBC) filtration in platelet rich plasma (PRP) and platelet poor plasma (PPP) was equally decreased (p < 0.0001) in 120 patients with acute myocardial infarction (AMI) as compared to a control group. In a double-blind experiment 2 groups of 30 patients with AMI received an acute oral dose of 60 mg of ketanserin, a serotonin (5-HT) antagonist at 5-HT2-receptors, or placebo. Ketanserin treatment improved RBC filtration in PRP with an average increase of 30%. A similar experiment using PPP showed a significant increase of 10%. Filtration of plasma improved after ketanserin treat

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4

Das, Dr Debashree. "A Fluorescent Heterobimetallic IrIII-PdII Complex (HBMC) Selectively Images Cancer Cells." In 8th World Conference on Chemistry and Chemical Engineering and 8th World Conference on Advanced Materials, Nanoscience and Nanotechnology. Eurasia Conferences, 2025. https://doi.org/10.62422/978-81-981865-7-7-018.

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Early detection and treatment of cancer cell is the only way to eradicate cancer in patients and this can be efficiently achieved via fluorescence imaging technique. Henceforth, we present a fluorescent heterobimetallic complex (HBMC) of Ir(III)/Pd(II) which selectively images the nucleus of the cancer cells over normal cells at a very low concentration (12 μM), established by confocal laser scanning microscopy. HBMC has a unique property by virtue of which it is selectively taken up by cancer cells (HeLa) and hence allows selective imaging of cancer cells over normal cells (HaCat). However, t

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5

"PS-054 - VORTIOXETINA EN PACIENTES CON TRASTORNO POR USO DE SUSTANCIAS Y DEPRESIÓN." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.ps054.

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DESCRIPCIÓN DE OBJETIVOS: Vortioxetina es un antidepresivo multimodal con un mecanismo de acción novedoso y complejo que está relacionado con la modulación directa de la actividad del receptor serotoninérgico y la inhibición del transportador de la serotonina (5-HT). Se utiliza para tratar la depresión mayor en adultos. Cuenta con buen perfil de tolerabilidad y seguridad y beneficios en la función cognitiva. Los pacientes con trastorno por uso de sustancias suelen presentar otros síndromes psiquiátricos asociados, entre los más frecuentes la depresión, que con frecuencia son trastornos inducid

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Звіти організацій з теми "Serotonin (5-HT) receptors"

1

Yan, Qingshan. Ethanol and Mesolimbic Serotonin/Dopamine Interactions via 5-HT-1B Receptors. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada443060.

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