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Готові списки джерел за темами / SERPINH1 / Статті в журналах

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Статті в журналах з теми "SERPINH1"

Автор: Grafiati

Опубліковано: 7 липня 2024

Оновлено: 31 липня 2025

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1

Al-Khatib, Sohaib M., Ayah N. Al-Bzour, Mohammad N. Al-Majali, et al. "Exploring Genetic Determinants: A Comprehensive Analysis of Serpin B Family SNPs and Prognosis in Glioblastoma Multiforme Patients." Cancers 16, no. 6 (2024): 1112. http://dx.doi.org/10.3390/cancers16061112.

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Serpins are serine proteinase inhibitors, with several serpins being overexpressed in cancer cells. Thus, we aim to analyze the single-nucleotide polymorphism (SNP) of Serpinb11 and its association with GBM survival. A cohort of 63 GBM patients recruited from King Abdullah University Hospital in Jordan underwent polymorphism analysis and overall survival (OS) assessments. The Cancer Genome Atlas (GBM) cohort was useful for validation. We constructed a risk score using the principal component analysis for the following Serpin genes: Serpinb3, Serpinb5, Serpinb6, Serpinb11, and Serpinb12, and pa

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2

Jin, Xiao-Sheng, Lu-Xi Chen, Ting-Ting Ji, and Rong-Zhou Li. "SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway." World Journal of Gastrointestinal Oncology 16, no. 5 (2024): 1890–907. http://dx.doi.org/10.4251/wjgo.v16.i5.1890.

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BACKGROUND Serpin peptidase inhibitor clade H member 1 (SERPINH1) was initially recognized as an oncogene implicated in various human malignancies. Nevertheless, the clinical relevance and functional implications of SERPINH1 in colorectal cancer (CRC) remain largely elusive. AIM To investigate the effects of SERPINH1 on CRC cells and its specific mechanism. METHODS Quantitative real-time polymerase chain reaction, western blotting analysis, The Cancer Genome Atlas data mining and immunohistochemistry were employed to examine SERPINH1 expression in CRC cell lines and tissues. A series of in-vit

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3

Haj, Amelia K., Sean J. Jurgens, Xin Wang, et al. "Rare Germline Loss-of-Function Variants in HSP47 ( SERPINH1) Are Associated with an Intermediate Osteogenesis Imperfecta Phenotype Characterized By Atopic Inflammation and Increased Risk of Thrombosis." Blood 142, Supplement 1 (2023): 3934. http://dx.doi.org/10.1182/blood-2023-189896.

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Background: There has been considerable interest in the collagen-specific chaperone HSP47 ( SERPINH1) as a potential drug target for the treatment of cirrhosis, fibrotic disease, and more recently, thrombosis (Thienel et al., Science 380, 178-187, 2023). While homozygous or compound heterozygous loss of function in SERPINH1 is known to cause a rare form of osteogenesis imperfecta (OI) in humans, little is known about the clinical effects of moderately decreased HSP47 activity. In order to assess the potential safety and efficacy of an antithrombotic strategy based on HSP47 blockade, we evaluat

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4

Liu, Qian, Yuanhao Peng, Wenbin Liu, and Xiangjian Luo. "SERPINH1 functions as a multifunctional regulator to promote the malignant progression of cervical cancer." PLOS One 20, no. 7 (2025): e0329007. https://doi.org/10.1371/journal.pone.0329007.

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Cervical cancer remains the second leading cause of female cancer mortality worldwide, with metastasis representing a critical therapeutic challenge. This study systematically reveals the key role of SERPINH1 (Serpin Family H Member 1) as a hub regulator of malignant progression in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Through analysis of TCGA-CESC datasets, we identified that high SERPINH1 expression is significantly correlated with poor prognosis and contributes to tumor progression by promoting cell proliferation, invasion, and metastatic phenotypes. In vi

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5

Mueller, S. K., A. L. Nocera, S. T. Dillon, T. A. Libermann, O. Wendler, and B. S. Bleier. "Tissue and Exosomal Serine Protease Inhibitors Are Significantly Overexpressed in Chronic Rhinosinusitis With Nasal Polyps." American Journal of Rhinology & Allergy 33, no. 4 (2019): 359–68. http://dx.doi.org/10.1177/1945892419831108.

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Background The fibrinolysis pathway has been previously implicated in the etiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Objective The purpose of this study was (1) to explore protein derangements of selected protease inhibitors of the serpin superfamily in CRSwNP and (2) to correlate the protease inhibitor derangements of the fibrinolysis pathway in tissue with exosomal samples to evaluate the potential of an exosomal noninvasive “liquid biopsy” for CRSwNP. Methods Institutional review board approved study in which matched tissue and mucus exosomal proteins (SerpinB2,

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6

Zhang, Yin, Chun-Yuan Li, Wei Ge, and Yi Xiao. "Exploration of the Key Proteins in the Normal-Adenoma-Carcinoma Sequence of Colorectal Cancer Evolution Using In-Depth Quantitative Proteomics." Journal of Oncology 2021 (June 11, 2021): 1–19. http://dx.doi.org/10.1155/2021/5570058.

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Purpose. In most cases, the carcinogenesis of colorectal cancer (CRC) follows the normal-adenoma-carcinoma (N-A-C) sequence. In this study, we aimed to identify the key proteins in the N-A-C sequence. Methods. Differentially expressed proteins (DEPs) in normal, adenoma, and carcinoma tissues were identified using the Tandem Mass Tag- (TMT-) based quantitative proteomics approach. The landscape of proteomic variation in the N-A-C sequence was explored using gene set enrichment analysis (GSEA) and Proteomaps. Key proteins in the N-A-C sequence were identified, verified, and validated based on ou

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7

Bertram, Stefanie, Juliet Padden, Julia Kälsch, et al. "Novel immunohistochemical markers differentiate intrahepatic cholangiocarcinoma from benign bile duct lesions." Journal of Clinical Pathology 69, no. 7 (2016): 619–26. http://dx.doi.org/10.1136/jclinpath-2015-203418.

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AimsThe distinction between intrahepatic cholangiocarcinoma (ICC) and benign bile duct lesions can be challenging. Using our previously identified potential biomarkers for ICC, we examined whether these are useful for the differential diagnosis of ICC, bile duct adenoma and reactive bile duct proliferations in an immunohistochemical approach and identified a diagnostic marker panel including known biomarkers.MethodsSubjects included samples from 77 patients with ICC, 33 patients with bile duct adenoma and 47 patients with ductular reactions in liver cirrhosis. Our previously identified biomark

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8

Tahmasbpour, E., A. Philp, C. Thomson, M. Plit, and D. Darley. "Overexpression of SerpinB1 and SerpinH1 in Transbronchial Biopsies of Patients with Eosinophilia and Chronic Lung Allograft Dysfunction." Journal of Heart and Lung Transplantation 44, no. 4 (2025): S388—S389. https://doi.org/10.1016/j.healun.2025.02.834.

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9

Zhang, Yin, Chun-Yuan Li, Meng Pan, et al. "Exploration of the Key Proteins of High-Grade Intraepithelial Neoplasia to Adenocarcinoma Sequence Using In-Depth Quantitative Proteomics Analysis." Journal of Oncology 2021 (November 29, 2021): 1–13. http://dx.doi.org/10.1155/2021/5538756.

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Purpose. In this study, we aimed to provide a comprehensive description of typical features and identify key proteins associated with the high-grade intraepithelial neoplasia- (HIN-) adenocarcinoma (AC) sequence. Methods. We conducted tandem mass tag-based quantitative proteomic profiling of normal mucosa, HIN, and AC tissues. Protein clusters representative of the HIN-AC sequence were identified using heatmaps based on Pearson’s correlation analysis. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Reactome analyses were performed using the Database for Annotation, Visu

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10

van Leeuwen, L. Leonie, Mitchel J. R. Ruigrok, Henri G. D. Leuvenink, and Peter Olinga. "Slice of Life: Porcine Kidney Slices for Testing Antifibrotic Drugs in a Transplant Setting." Transplantology 4, no. 2 (2023): 59–70. http://dx.doi.org/10.3390/transplantology4020007.

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Circulatory death donor (DCD) kidneys are increasingly used to enlarge the donor pool. These kidneys undergo ischemia-reperfusion injury, frequently leading to renal fibrosis. Transforming growth factor beta 1 (TGF-β1) and matrix metalloproteases have been identified as central mediators of fibrosis and inhibition of these targets could attenuate fibrosis. We studied whether galunisertib, doxycycline, taurine, and febuxostat alleviated fibrosis in precision-cut kidney slices (PCKS). PCKS were prepared from porcine kidneys that were exposed to 30 min of warm ischemia followed by 3 h of oxygenat

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11

Brzhozovskiy, Alexander G., Alexey S. Kononikhin, Lyudmila Ch Pastushkova, et al. "The Effects of Spaceflight Factors on the Human Plasma Proteome, Including Both Real Space Missions and Ground-Based Experiments." International Journal of Molecular Sciences 20, no. 13 (2019): 3194. http://dx.doi.org/10.3390/ijms20133194.

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The aim of the study was to compare proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based experiments. LC–MS/MS-based proteomic analysis of blood plasma samples obtained from 13 cosmonauts before and after long-duration (169–199 days) missions on the International Space Station (ISS) and for five healthy men included in 21-day-long head-down bed rest (HDBR) and dry immersion experiments were performed. The semi-quantitative label-free analysis revealed significantly changed proteins: 19 proteins were significantly different

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12

Al-Khatib, Sohaib, Mohammad Nitham Almajali, Ayah Al-Bzour, Joud Al-Ramadneh, Laila Sa'd, and Noor Othman. "Abstract 5594: Exploring genetic determinants: A comprehensive analysis of SERPINB family variants and prognosis in Jordanian glioblastoma multiforme patients." Cancer Research 84, no. 6_Supplement (2024): 5594. http://dx.doi.org/10.1158/1538-7445.am2024-5594.

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Abstract Background: Glioblastoma multiforme (GBM) is a major concern with high fatality rate. In Jordan, the incidence of GBM has notably increased, emphasizing the urgency for population-specific research. Serpins are serine proteinase inhibitors, with several Serpins being overexpressed in cancer cells however the exact mechanism by which they affect GBM progression remains unclear. Thus, we aim to analyze the single-nucleotide polymorphism (SNP) of SERPINB11 and its association with GBM survival. Methods: A cohort of 63 GBM patients recruited from King Abdullah University Hospital (KAUH) i

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13

Zhang, Hailin, Xiaodi Yan, Hongmei Gu, Qiang Xue, and Xiancheng Liu. "High SERPINH1 expression predicts poor prognosis in lung adenocarcinoma." Journal of Thoracic Disease 14, no. 12 (2022): 4785–802. http://dx.doi.org/10.21037/jtd-22-1518.

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14

Zhang, Shuyuan, Weiwei Zhang, Bin Wu, et al. "Hub gene target of glioblastoma: LOX, SERPINH1 and TGFBI." Medicine 101, no. 45 (2022): e31418. http://dx.doi.org/10.1097/md.0000000000031418.

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15

Xia, Kezhou, Xinghan Huang, Yingchun Zhao, Isabelle Yang, and Weichun Guo. "SERPINH1 enhances the malignancy of osteosarcoma via PI3K-Akt signaling pathway." Translational Oncology 39 (January 2024): 101802. http://dx.doi.org/10.1016/j.tranon.2023.101802.

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16

Cochran, Blake J., David R. Croucher, Sergei Lobov, Darren N. Saunders, and Marie Ranson. "Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer." Journal of Biological Chemistry 286, no. 27 (2011): 24467–75. http://dx.doi.org/10.1074/jbc.m111.225706.

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Tumor overexpression of urokinase-type plasminogen activator (uPA) and its specific inhibitor SerpinE1 (plasminogen activator inhibitor type-1) correlates with poor prognosis and increased metastatic potential. Conversely, tumor expression of uPA and another specific inhibitor, SerpinB2 (plasminogen activator inhibitor type-2), are associated with favorable outcome and relapse-free survival. It is not known how overexpression of these uPA inhibitors results in such disparate outcomes. A possible explanation may be related to the presence of a proposed low density lipoprotein receptor (LDLR)-bi

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17

Charone, Senda, Erika Calvano Küchler, Aline de Lima Leite, et al. "Analysis of Polymorphisms in Genes Differentially Expressed in the Enamel of Mice with Different Genetic Susceptibilities to Dental Fluorosis." Caries Research 53, no. 2 (2018): 228–33. http://dx.doi.org/10.1159/000491554.

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Genes expressed during amelogenesis are candidates to increase the risk of dental fluorosis (DF). Thus, this study aimed to evaluate the association between polymorphisms in enamel development genes and susceptibility to DF in mice. Mice of both sexes, representing strains 129P3/J (n = 20; resistant to DF) and A/J (n = 20; susceptible to DF), were divided into 2 groups. Each strain received a diet with a low concentration of fluoride (F) and drinking water containing 0 or 50 mg/L of F for 6 weeks. Clinical evaluation and analysis of Vickers enamel microhardness of the incisors were performed.

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18

Drögemüller, Cord, Doreen Becker, Adrian Brunner, et al. "A Missense Mutation in the SERPINH1 Gene in Dachshunds with Osteogenesis Imperfecta." PLoS Genetics 5, no. 7 (2009): e1000579. http://dx.doi.org/10.1371/journal.pgen.1000579.

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19

Wang, Shuai, Zhiming Sun, Chao Wang, et al. "The JAK1/STAT3 pathway mediates the effects of SERPINH1 on glioma EMT." International Immunopharmacology 157 (June 2025): 114731. https://doi.org/10.1016/j.intimp.2025.114731.

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20

Winkler, Ingrid G., Jean Hendy, Paul Coughlin, Anita Horvath, and Jean-Pierre Lévesque. "Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization." Journal of Experimental Medicine 201, no. 7 (2005): 1077–88. http://dx.doi.org/10.1084/jem.20042299.

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Mobilization of hematopoietic progenitor cells into the blood involves a massive release of neutrophil serine proteases in the bone marrow. We hypothesize that the activity of these neutrophil serine proteases is regulated by the expression of naturally occurring inhibitors (serpina1 and serpina3) produced locally within the bone marrow. We found that serpina1 and serpina3 were transcribed in the bone marrow by many different hematopoietic cell populations and that a strong reduction in expression occurred both at the protein and mRNA levels during mobilization induced by granulocyte colony-st

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21

Kranc, Wiesława, Maciej Brązert, Katarzyna Ożegowska, et al. "Response to abiotic and organic substances stimulation belongs to ontologic groups significantly up-regulated in porcine immature oocytes." Medical Journal of Cell Biology 6, no. 3 (2018): 91–100. http://dx.doi.org/10.2478/acb-2018-0015.

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Abstract The efficiency of the process of obtaining mature oocytes, and then of porcine embryos in vitro depends on many factors and requires meeting many conditions. These include selection of morphologically appropriate oocytes, selection of appropriate medium components, as well as a number of abiotic factors (appropriate microenvironment during in vitro culture). Oocytes were taken from 45 pubertal crossbred Landrace gilts. The BCB test was carried out. BCB + oocytes were divided into two groups: “before IVM” and “after IVM”. “Before IVM” oocytes were subjected to molecular analyzes immedi

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22

Zapata, Liliana Mejia. "Novel heterozygous mutations in gene SERPINH1 cause autosomal recessive osteogenesis imperfecta type X." Bone Reports 14 (April 2021): 100994. http://dx.doi.org/10.1016/j.bonr.2021.100994.

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23

Kishimoto, Yo, Masaru Yamashita, Alice Wei, et al. "Reversal of Vocal Fold Mucosal Fibrosis Using siRNA against the Collagen-Specific Chaperone Serpinh1." Molecular Therapy - Nucleic Acids 16 (June 2019): 616–25. http://dx.doi.org/10.1016/j.omtn.2019.04.014.

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24

Song, Y., D. Zhao, X. Xu, et al. "Novel compound heterozygous mutations in SERPINH1 cause rare autosomal recessive osteogenesis imperfecta type X." Osteoporosis International 29, no. 6 (2018): 1389–96. http://dx.doi.org/10.1007/s00198-018-4448-2.

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25

Tian, Shan, Pailan Peng, Jiao Li та ін. "SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway". Aging 12, № 4 (2020): 3574–93. http://dx.doi.org/10.18632/aging.102831.

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26

Burgener, Sabrina S., Mathias Baumann, Paola Basilico, Eileen Remold-O’Donnell, Ivo P. Touw, and Charaf Benarafa. "Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1." Biological Chemistry 397, no. 9 (2016): 897–905. http://dx.doi.org/10.1515/hsz-2016-0132.

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Abstract Serpinb1 is an inhibitor of neutrophil granule serine proteases cathepsin G, proteinase-3 and elastase. One of its core physiological functions is to protect neutrophils from granule protease-mediated cell death. Mice lacking Serpinb1a (Sb1a-/-), its mouse ortholog, have reduced bone marrow neutrophil numbers due to cell death mediated by cathepsin G and the mice show increased susceptibility to lung infections. Here, we show that conditional deletion of Serpinb1a using the Lyz2-cre and Cebpa-cre knock-in mice effectively leads to recombination-mediated deletion in neutrophils but pro

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27

Alhalabi, O., M. Göttmann, M. Gold, et al. "P04.04 Optimizing dasatinib for glioblastoma treatment." Neuro-Oncology 23, Supplement_2 (2021): ii19. http://dx.doi.org/10.1093/neuonc/noab180.061.

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Abstract BACKGROUND Glioblastoma is the most common primary malignancy of the central nervous system with a dismal prognosis, even with surgical and chemoradiotherapy. Expression profiling studies classify IDH-wildtype Glioblastoma into three subtypes: Proneural (PN), mesenchymal (MES) and classical (CL). A promising target to inhibit in Glioblastoma is the non-receptor tyrosine kinase and proto-oncogene SRC. After robust pre-clinical results, SRC inhibitors like dasatinib did not improve survival of Glioblastoma patients after recurrence in clinical trials. MATERIAL AND METHODS Consolidating

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28

Sivaprasad, Umasundari, Kayla Kinker, Aaron Gibson, et al. "Role of SERPINB3, SERPINB4, and their mouse homolog Serpinb3a in allergen-induced cutaneous inflammation. (P3347)." Journal of Immunology 190, no. 1_Supplement (2013): 210.5. http://dx.doi.org/10.4049/jimmunol.190.supp.210.5.

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Abstract The serine protease inhibitors SERPINB3 and SERPINB4 have been implicated in allergic disorders. We have recently demonstrated a role for the serine protease inhibitor Serpinb3a (the mouse homolog of SERPINB3 and SERPINB4) in a mouse model of asthma. Elevated levels of SERPINB3 and SERPINB4 are detected in the serum of patients with atopic dermatitis (AD) and they have been proposed as possible biomarkers for AD. Serine proteases are critical for epidermal barrier homeostasis and aberrant expression and/or activity of serine proteases have been associated with AD in human studies. We

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29

Huang, H., T. Chen, L. Zhen, et al. "Mechanism of SERPINH1 in promoting bone metastasis of prostate cancer by inhibiting P62 ubiquitination degradation." European Urology 83 (February 2023): S1661. http://dx.doi.org/10.1016/s0302-2838(23)01186-7.

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30

Gajewski, T., Y. Zha, B. Thurner, and G. Schuler. "Association of gene expression profile in metastatic melanoma and survival to a dendritic cell-based vaccine." Journal of Clinical Oncology 27, no. 15_suppl (2009): 9002. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.9002.

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9002 Background: Emerging data suggests that features of the melanoma tumor microenvironment may determine the clinical outcome to immunotherapies. We recently have observed a gene expression signature that correlated with a favorable clinical outcome in response to an IL-12-based melanoma vaccine. Increased expression of chemokine genes and T cell transcripts, and decreased expression of genes associated with aggressive tumor biology, were observed in the favorable group. To determine whether these patterns were reproducible, gene expression profiling was performed from an independent vaccine

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31

Tahmasbpour, Eisa, Ashleigh Philp, Vanathi Sivasubramaniam, et al. "Proteomic Analysis of Transbronchial Biopsies to Discover Novel Biomarkers for Early Identification of Chronic Lung Allograft Dysfunction." Transplantation Direct 11, no. 6 (2025): e1800. https://doi.org/10.1097/txd.0000000000001800.

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Background. Chronic lung allograft dysfunction (CLAD) is a major contributor to poor long-term survival after lung transplantation (LTx). There is a paucity of validated tissue biomarkers which limits the early detection of CLAD. The aim of this study was to discover novel tissue proteins in CLAD. Methods. A longitudinal cohort study analyzed 15 tissue specimens from 2 groups of bilateral LTx recipients; those with CLAD (n = 3) and those without CLAD (n = 3). In both groups, transbronchial biopsies (TBBx) were retrieved from 2 timepoints; stable surveillance at 90 d after transplant, and durin

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32

Kamikawaji, Kazuto, Naohiko Seki, Masaki Watanabe, et al. "Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis." Journal of Human Genetics 61, no. 12 (2016): 985–93. http://dx.doi.org/10.1038/jhg.2016.99.

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Xiao, Hua, Zhaoying Yao, Tao Li, et al. "SERPINH1 secretion by cancer-associated fibroblasts promotes hepatocellular carcinoma malignancy through SENP3-mediated SP1/SQLE pathway." International Immunopharmacology 150 (March 2025): 114259. https://doi.org/10.1016/j.intimp.2025.114259.

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34

Razali, Nurhanani, Azlina Abdul Aziz, Chor Yin Lim, and Sarni Mat Junit. "Investigation into the effects of antioxidant-rich extract ofTamarindus indicaleaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells." PeerJ 3 (October 1, 2015): e1292. http://dx.doi.org/10.7717/peerj.1292.

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The leaf extract ofTamarindus indicaL. (T. indica) had been reported to possess high phenolic content and showed high antioxidant activities. In this study, the effects of the antioxidant-rich leaf extract of theT. indicaon lipid peroxidation, antioxidant enzyme activities, H2O2-induced ROS production and gene expression patterns were investigated in liver HepG2 cells. Lipid peroxidation and ROS production were inhibited and the activity of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase was enhanced when the cells were treated with the antioxidant-rich leaf extra

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35

Kantaputra, Piranit, Teerada Daroontum, Mati Chuamanochan, et al. "SERPINB3, Adult-Onset Immunodeficiency, and Generalized Pustular Psoriasis." Genes 14, no. 2 (2023): 266. http://dx.doi.org/10.3390/genes14020266.

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Background: Generalized pustular psoriasis (GPP; MIM 614204) is a rare and severe pustular autoinflammatory skin disease in which acute generalized erythema and scaling develop with numerous sterile pustules. GPP shares skin manifestations, especially pustular skin reaction, with adult-onset immunodeficiency (AOID) with anti-interferon-γ autoantibodies, an autoimmune disease. Methods: Clinical examinations and whole-exome sequencing (WES) were performed on 32 patients with pustular psoriasis phenotypes and 21 patients with AOID with pustular skin reaction. Immunohistochemical and histopatholog

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36

Kawagoe, Kosuke, Masumi Wada, Tetsuya Idichi, et al. "Regulation of aberrantly expressed SERPINH1 by antitumor miR-148a-5p inhibits cancer cell aggressiveness in gastric cancer." Journal of Human Genetics 65, no. 8 (2020): 647–56. http://dx.doi.org/10.1038/s10038-020-0746-6.

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37

Marshall, Charlotte, Jaime Lopez, Laura Crookes, Rebecca C. Pollitt, and Meena Balasubramanian. "A novel homozygous variant in SERPINH1 associated with a severe, lethal presentation of osteogenesis imperfecta with hydranencephaly." Gene 595, no. 1 (2016): 49–52. http://dx.doi.org/10.1016/j.gene.2016.09.035.

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Fazlic, M., R. Fairclough, S. Fraser, et al. "434. Identification of differentially expressed proteins in ovine chorion rupture sites at preterm and term using proteomics." Reproduction, Fertility and Development 20, no. 9 (2008): 114. http://dx.doi.org/10.1071/srb08abs434.

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Introduction: A significant number of babies are delivered preterm and many of these deliveries are due to spontaneous rupture of fetal membranes. However, the mechanisms underlying fetal membrane rupture are not well defined. The sheep has proved to be a valuable model for elucidating the physiology of birth, with many of the findings clearly relevant to human parturition. In the current study we have used the sheep model to investigate changes in protein expression in the chorion in relation to the onset of spontaneous full term labour. Methods: Proteomic analysis was used to compare the pro

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Pomerleau, V., V. Reyes-Nicolas, C. Jurkovic, F. Boisvert, and N. Perreault. "A7 FOXL1+ TELOCYTES IN MOUSE COLON ORCHESTRATE ECM BIODYNAMICS AND WOUND REPAIR RESOLUTION." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (2022): 8–9. http://dx.doi.org/10.1093/jcag/gwab049.006.

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Abstract Background The extracellular matrix (ECM) is a complex assembly of proteins that provide mechanical and biochemical stimuli to the epithelial and mesenchymal cells of the GI mucosa. Deficiencies in ECM assembly, protein production or excessive accumulation can lead to multiples pathologies including fibrosis and cancer. FoxL1+-Telocytes (TCFoxL1+) are subepithelial cells that form a network underneath the epithelium, contributing to the microenvironment that supports epithelial and immune cell homeostasis. We have previously shown that BMPR1A signaling deletion in TCFoxL1+ influences

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Crawford, Andrew A., Sean Bankier, Elisabeth Altmaier, et al. "Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease." Journal of Human Genetics 66, no. 6 (2021): 625–36. http://dx.doi.org/10.1038/s10038-020-00895-6.

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AbstractThe stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning plasma cortisol. Identifying additional genetic variants that explain more of the variance in cortisol could provide new insights into cortisol biology and provide statistical power to test the causative role of cortisol in common diseases. The CORNET consortium extended its genome-wide association meta-analysis for morning plasma cortisol from 12,597 to 25,314 subjects

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Widmer, C., J. M. Gebauer, E. Brunstein, et al. "Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition." Proceedings of the National Academy of Sciences 109, no. 33 (2012): 13243–47. http://dx.doi.org/10.1073/pnas.1208072109.

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Haj, A., S. Jurgens, X. Wang, et al. "LB 01.4 Rare Germline Loss of Function Variants in SERPINH1 (HSP47) are Associated with Increased Risk of Thrombosis." Research and Practice in Thrombosis and Haemostasis 7 (October 2023): 100291. http://dx.doi.org/10.1016/j.rpth.2023.100291.

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Zvereff, Val, Azza Abd El Moneim Attia, Amal Al Tenaiji, Sana Islam, Anushree Dileep, and Shalini Behl. "P699: Identification of a novel pathogenic variant in SERPINH1 associated with a presentation of osteogenesis imperfecta: Case study." Genetics in Medicine Open 2 (2024): 101603. http://dx.doi.org/10.1016/j.gimo.2024.101603.

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Marques, Patrícia Isabel, Zélia Ferreira, Manuella Martins, et al. "SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1." PLoS ONE 8, no. 6 (2013): e66889. http://dx.doi.org/10.1371/journal.pone.0066889.

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Kloth, JN, A. Gorter, GJ Fleuren, et al. "Elevated expression of SerpinA1 and SerpinA3 in HLA-positive cervical carcinoma." Journal of Pathology 215, no. 3 (2008): 222–30. http://dx.doi.org/10.1002/path.2347.

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Li, Mengdi, Shuheng Huang, Yong Zhang та ін. "Regulation of the unfolded protein response transducer IRE1α by SERPINH1 aggravates periodontitis with diabetes mellitus via prolonged ER stress". Cellular Signalling 91 (березень 2022): 110241. http://dx.doi.org/10.1016/j.cellsig.2022.110241.

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Wu, Gang, Xueming Ju, Youyu Wang, Zhixi Li, and Xianfeng Gan. "Up-regulation of SNHG6 activates SERPINH1 expression by competitive binding to miR-139-5p to promote hepatocellular carcinoma progression." Cell Cycle 18, no. 16 (2019): 1849–67. http://dx.doi.org/10.1080/15384101.2019.1629772.

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Wang, Yanni, Zhe Liu, Zhen Li, et al. "Effects of heat stress on respiratory burst, oxidative damage and SERPINH1 (HSP47) mRNA expression in rainbow trout Oncorhynchus mykiss." Fish Physiology and Biochemistry 42, no. 2 (2015): 701–10. http://dx.doi.org/10.1007/s10695-015-0170-6.

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Bostanci, Mehmet Suhha, Merih Bayram, Suleyman Murat Bakacak, et al. "The role of TWIST, SERPINB5, and SERPIN1 genes in uterine leiomyomas." Journal of the Turkish German Gynecological Association 15, no. 2 (2014): 92–95. http://dx.doi.org/10.5152/jtgga.2014.13005.

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Tziastoudi, Maria, Georgios Pissas, Spyridon Golfinopoulos, et al. "Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study." International Journal of Molecular Sciences 25, no. 20 (2024): 10906. http://dx.doi.org/10.3390/ijms252010906.

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Diabetic kidney disease (DKD) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). Despite the numerous genetic loci that have been associated with the disease in T2DM, the genetic architecture of DKD remains unclear until today. In contrast to SERPINE1, the contribution of SERPINB2 has not been examined in DKD. Therefore, we conducted the first genetic association study of SERPINB2 to elucidate its role in DKD. In total, the study involved 197 patients with DKD, 155 patients with T2DM without microvascular complications (diabetic kidney disease, diabetic retinopathy, an

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