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Готові списки джерел за темами / Skin pharmacology / Дисертації

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Дисертації з теми "Skin pharmacology"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Lowman, Mark Andrew. "Studies on the biochemical pharmacology of human dispersed skin mast cells." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292929.

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2

Kärpänen, Tarja J. "Studies of skin antisepsis and enhanced penetration of chlorhexidine." Thesis, Aston University, 2008. http://publications.aston.ac.uk/15332/.

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Анотація:

Current evidence-based guidelines recommend that 2% (w/v) chlorhexidine digluconate (CHG), preferentially in 70% (v/v) isopropyl alcohol (IIPA), is used for skin antisepsis prior to incision of the skin. In this current study, the antimicrobial efficacy of CHG, six essential oils [tea tree oil (TTO), thymol, eucalyptus oil (EO), juniper oil, lavender oil and citronella] and novel benzylidenecarboxamidrazone and thiosemicarbazone compounds were determined against a panel of microorganisms commonly associated with skin infection (Staphylococcus epidermidis, S. aureus, meticillin-resistant S. aur

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3

Al-Otaibi, Faisal Obaid. "Pharmacokinetic studies of drug absorption into human skin." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/361.

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Optimum therapeutic outcomes require not only proper drug selection but also effective drug delivery and monitoring. The aim of this thesis was to A) study drug delivery through the skin with a liquid formulated to promote absorption, B) develop and validate methods to analyze the drug in the samples obtained, C) assess appropriate methods to measure the transdermal delivery of drug, and D) apply to pharmacodynamics. The stability of a rectal formulation of diazepam, Diastat®, and a quality control of a topical form, TDS® diazepam, were studied using high performance liquid chromatography (HPL

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4

McCallion, C. Rosaleen. "An evaluation of skin moisturizers." Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317454.

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5

Al-Mayahy, Mohammed Hussain Neama. "Insights regarding drug permeation into skin." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47341/.

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Анотація:

In order to develop safe and effective topical and transdermal formulations to treat either local skin disorders or for systemic drug delivery, it is first imperative to assess skin permeation using a reliable and comprehensive analysis method. The assessment of drug permeation into/across the skin is traditionally accomplished using Franz diffusion cells with subsequent analysis by conventional chromatographic methods such as HPLC and more recently using advanced imaging techniques. In this context, time of flight-secondary ion mass spectrometry (ToF-SIMS) offers distinctive advantages in map

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6

Ramien, Michele. "Parasympathetic innervation of the rat lower lip skin following sensory denervation." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19426.

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Анотація:

The sympathetic division of the autonomic nervous system is known to play a role in the genesis of neuropathic pain. In the skin of the rat lower lip (hairy skin), sympathetic and parasympathetic fibres normally innervate the same blood vessels in the lower dermis but do not occur in the upper dermis. However, we have shown that sympathetic fibre migration into the upper dermis occurs following mental nerve lesions (1. Compo Neurol. 422:287-296, 2000). As sensory denervation has a dramatic effect on sympathetic fibre innervation patterns in the rat lower lip skin, we decided to investigate the

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7

Peleshok, Jennifer. "Skin innervation patterns and neurotrophic factor expression in neuropathic pain models." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106359.

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Анотація:

Neuropathic pain presents itself with many faces. It can be devastatingly painful leading to a person's inability to lead a productive life or it can be mild. In this thesis I discuss one of the countless possible mechanisms which could underlie the development and maintenance of this disorder; namely the involvement of peripheral changes in innervation. The approach taken in this thesis was mainly based on protein analyses, based on the assumption that protein expression (or lack thereof) is indicative of changes in the physiological properties of structures that either express or secrete pr

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8

Akhter, S. A. "Drug penetration and enhancement through human skin." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371463.

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9

Ruocco, Isabella. "Sensory and autonomic innervation of the skin of the rat lower lip." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38091.

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In this thesis, the innervation patterns by substance P- (SP), dopamine-beta-hydroxylase- (DbetaH) and the vesicular acetylcholine transporter- (VAChT) immunoreactive (IR) fibres were investigated in the skin of the rat lower lip, in order to provide a morphological basis for the possible interactions between sensory and autonomic fibres in the periphery. Our immunocytochemical approach revealed that SP-IR sensory fibres were widely distributed throughout the epidermis and dermis. In the dermis, they were associated with blood vessels, hair follicles, sebaceous glands and mast cells. Electron

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10

Ivory, Matthew Owen. "Characterising skin immune cells to inform development of intradermal vaccines and therapeutics." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/96969/.

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Epidermal Langerhans cells (LCs) and multiple subsets of dermal dendritic cells (dDCs) make skin a valuable route for vaccination, offering the potential for antigen-sparing immunisation. The interconnected immunological functions of dDC subsets and LCs are not fully understood however. This Thesis therefore aimed to explore the interactions of skin immune cells with viral pathogens and vaccines to inform the development of future therapeutics and intradermal vaccines. LCs and dDCs were isolated from ex vivo human skin tissue using a walkout protocol which allowed the enrichment of the migrato

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11

Monshi, Manal. "Characterisation of the cellular basis of beta-lactam induced skin and liver injury." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/18373/.

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Анотація:

Drug hypersensitivity reactions are a significant cause of patient morbidity and mortality. They are difficult to predict in the clinic and during the drug development process. This is because mechanisms have not been fully elucidated. In fact, recent data using T-cells cloned from hypersensitive human patients have questioned the long-standing hapten concept, which states that a drug must bind irreversibly to protein to initiate a T-cell response. The work described herein was performed to investigate the chemical and cellular mechanisms of β-lactam-induced skin and liver injury and in partic

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12

Aziza, M. A. E. "In vitro studies on drug diffusion through skin membranes and gastrointestinal tract." Thesis, University of Salford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372139.

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13

McVean, Maralee 1967. "Photoprotective actions of vitamin E in mouse skin: Prevention of UVB-induced DNA photodamage." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282563.

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Анотація:

Ultraviolet exposure causes epidermal damage including induction of cyclobutane pyrimidine dimers in DNA. Accumulation of these lesions has been associated with mutagenesis and probably contributes to development of nonmelanoma skin cancer. Topically applied α-tocopherol previously has been shown to prevent UVB induced damage and skin tumor induction in mice. Thus, α-tocopherol, which absorbs strongly in the UVB, may act as a sunscreen to prevent photodamage. This dissertation explored possible mechanisms of photoprotection exerted by α-tocopherol. The UVB dose penetrating the epidermis was me

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14

Grelik, Cynthia. "Nerve-injury evoked changes in the innervation of the skin of the rat lower lip." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84036.

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Анотація:

The general aim of the experiments conducted for this thesis was to determine whether there are morphological changes in the innervation of the skin underlying states of neuropathic pain. More specifically, this thesis was immediately addressing the question of whether autonomic fibers sprout de novo into the upper dermis of the rat lower lip following bilateral chronic constriction injury (CCI) of the mental nerve, a purely sensory branch of the trigeminal. In addition to the main objective, we sought to determine whether and to what extent the peptidergic and non-peptidergic populatio

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15

Basson, Erina. "Effect of ultrasound on transdermal permeation of diclofenac and the temperature effects on human skin." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/2166.

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Анотація:

Thesis (MScMed (Pharmacology))--University of Stellenbosch, 2005.<br>During the last two decades the effects of ultrasound on the transdermal diffusion of a wide variety of drugs have been extensively investigated. Because there is much uncertainty regarding the efficacy of and mechanisms involved in this mode of permeation enhancement, the objective of the study was to investigate the effect of ultrasound on the transdermal permeation of the nonsteroidal anti-inflammatory drug, diclofenac. For this purpose a dual-stage experimental design and a continuous flow-through diffusion system was use

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16

Bouvet, Raphaël. "Traitement des ulcérations cutanées par nanoencapsulation d’agents actifs. Mise au point et preuve de concept." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAS018.

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La cicatrisation est un processus multifactoriel. Dans le cadre du diabète, on retrouve une altération des processus à l’œuvre lors de la cicatrisation. En effet, l’hyperglycémie chronique présente chez le patient diabétique modifie la fonction des tissus principalement au niveau endothélial ainsi qu’au niveau cutané.Les ulcères chroniques du patient diabétique sont un problème majeur de santé publique avec une thérapeutique actuelle limité en efficacité. Ils représentent un facteur majeur de détérioration de la qualité de vie avec un risque d’amputation des membres inférieurs important.Lors d

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17

Kwok, Hoi Hin. "The anti-aging effects of ginsenosides on human endothelial cells and dermal fibroblasts." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1235.

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18

Georgakopoulos, Christos O. "Evaluation of lectins as tools to study glycosylation changes in malignant melanoma of the skin." Thesis, University of Portsmouth, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310420.

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19

Knox, C. N. "On pulsed irradiation studies of furocoumarins and related compounds used in the photochemotherapy of hyperproliferative skin diseases." Thesis, University of the West of Scotland, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373415.

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20

Kramer-Stickland, Kimberly Ann 1970. "Fate of vitamin E in UVB-irradiated mouse skin and in vitro systems: Antioxidant and photochemistry." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/288782.

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Анотація:

Photochemical and antioxidant reactions of α-tocopherol (α-TH, vitamin E) were studied by monitoring the fate of α-TH in UVB irradiated liposomes, solution, and mouse skin. α-TH was rapidly depleted in UVB irradiated mouse skin and in vitro systems. Oxidative damage, assessed by monitoring lipid peroxidation, was suppressed in UVH-irradiated liposomes until α-TH was depleted to 20% of initial levels. In all three systems, products previously identified as marker products for peroxyl radical scavenging by α-TH were observed, including α-tocopherolquinone (α-TQ), α-tocopherolquinone 2,3-epoxide

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21

Castellanos, Amber. "The Role of IGF-1 In Geriatric Skin." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1588759288275605.

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22

Springett, Kathryn. "The influence of forces generated during gait on the clinical appearance and physical properties of skin callus." Thesis, University of Brighton, 1993. https://research.brighton.ac.uk/en/studentTheses/d46b8c79-6d9c-40b4-8a66-3f8922e8b784.

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Plantar skin callus plaques are a common, frequently painful hyperkeratotic condition affecting a number of the population and these hard, dense, yellowish, cutaneous lesions may even be sufficiently severe to limit working practices and social activities. Pathological callus formation is thought, empirically from clinical observation, to be due to excess intermittent pressure during gait, associated frequently with a structural or functional anomaly of the foot and leg. Studies into callus pathology are relatively few and have been concerned mainly with the structure and ultrastructure of cal

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23

Zeppetella, Giovambattista. "Topically applied opioids for the management of painful cutaneous ulcers in a palliative care setting." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8518.

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Painful cutaneous ulcers are a clinical challenge as the pain can be difficult to control, frequently requiring a combination of pharmacological and non-pharmacological measures. There is evidence suggesting topical opioid application might be efficacious in the management of painful cutaneous ulcers, however this is largely based on case reports. Methods A series of clinical and laboratory studies were undertaken to determine the utility of opioids applied topically to painful cutaneous ulcers, these included surveys of hospice admissions to determine the prevalence of painful ulcers and the

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24

Lamore, Sarah Diane. "Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/228173.

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Анотація:

Chronic exposure to solar UVA plays a causative role in skin photoaging and photocarcinogenesis. Guided by exploratory difference-in-gel-electrophoresis (DIGE)-proteomics, we identified the thiol-dependent cysteine-proteases cathepsin B and cathepsin L as novel UVA-targets undergoing photo-oxidative inactivation upstream of autophagic-lysosomal dysfunction. In human skin fibroblasts, exposure to noncytotoxic doses of chronic UVA (9.9 J/cm ², twice a week, 3 weeks) caused pronounced photooxidative impairment of cathepsin B and L enzymatic activity suppressed by antioxidant intervention. West

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25

Gonterman, Ryan M. "Parathyroid hormone-related protein gene expression and function relationship with oncogenic pathways in the skin and squamous cell carcinomas of the lung /." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324517.

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Thesis (Ph.D.)--Indiana University, Dept. of Medical Sciences, 2008.<br>Title from PDF t.p. (viewed on May 13, 2009). Source: Dissertation Abstracts International, Volume: 69-08, Section: B, page: 4693. Adviser: John G. Foley.

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26

EPPLER, ANGELA RAE. "ASSESSMENT OF SKIN ABSORPTION AND IRRITATION POTENTIAL OF ARACHIDONIC ACID AND GLYCERYL ARACHIDONATE USING IN VITRO DIFFUSION CELL TECHNIQUES." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1115909169.

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27

Mahajan, Avinash Satyanarayan. "Effects of Creatine and Nicotinamide on experimentally induced senescence in dermal fibroblasts." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1598885573707503.

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28

Robson, Denise Lesley. "Buprenorphine hydrochloride permeation through human skin in vitro; the effect of chemical enhancement and iontophoresis : effect of pH, distribution ratio, penetration enhancers azone and oleyl alcohol, and iontophoresis on the permeation of buprenorphin." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329293.

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29

Ellison, Tara Ingrid. "The vitamin D endocrine system in skin uncoupling the actions of the vitamin D receptor and its ligand keratinocytes /." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1212784762.

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30

Dinsmore, Kristen, Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy PhD Brown, and Alexei MD Gonzalez-Estrada. "Refrigerated Stability of Diluted Cisatracurium, Rocuronium, and Vecuronium for skin testing after perioperative anaphylaxis." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/146.

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Анотація:

Rationale: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. Methods: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilutio

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31

RUWE, ANDREW R. "Design, Synthesis, and Biological Evaluation of Melanocortin-1-Receptor Agonists for the Prevention of Skin Cancer." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1218642304.

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32

Pothana, Kartheek. "Low dose UV-B induced keratinocyte exosomes protect Schwann cells against high glucose injury." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1610380812991387.

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33

Alkawar, Abdulrhaman Mohammed Mohammed. "Insulin-like growth factor-1 (IGF-1) impacts p53-regulated gene products in UVB-irradiated human keratinocytes and skin epidermis." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1588119867567084.

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34

Droog, Tesselaar Erik. "Assessment of microvascular function by use of transdermal iontophoresis : methodological aspects." Doctoral thesis, Linköpings universitet, Institutionen för medicinsk teknik, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8831.

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Анотація:

Assessment of the microcirculation is of major importance in understanding the physiology of the vasculature and in assessing te vascular effects of pathological conditions such as diabetes, hypertension and sepsis. Transdermal iontophoresis can be used to non‐invasively introduce vasoactive drugs into the skin. The response to these drugs of the local cutaneous microvasculature can be measured by laser Doppler flowmetry methods. Although these techniques have been used together for over two decades, there are still important methodological issues to be resolved. This work is aimed at optimizi

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35

Arikatla, Venkata Sravya. "Stress-Induced Senescence in Human Dermal Fibroblasts: Effects of Creatine and Nicotinamide Post Stress Treatment." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1629899898596448.

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36

Kannanayakal, Thomas Joseph. "Inflammatory Cytokines in Jet Propulsion Fuel-8 Induced Irritant Contact Dermatitis in Male Fischer Rats." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1242168249.

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37

Gogusetti, Vivek Shashank Nag. "Functions of ATR Kinase in Terminally Differentiated Human Epidermal Keratinocyles and in Human Ex-Vivo Skin After Exposure to Ultraviolet B Radiation." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1622357540982634.

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38

Sharifi, Bella. "The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma." Chapman University Digital Commons, 2019. https://digitalcommons.chapman.edu/pharmaceutical_sciences_theses/7.

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Анотація:

Apurinic/apyrimidinic DNA repair endonuclease-1 (APE1), first recognized as an important DNA excision repair enzyme, is also known as Redox Factor-1 (Ref-1) involved in the activation of many nuclear transcription factors in both redox-dependent and independent manner. It has been well-documented that the overexpression of APE/Ref-1 contributes to the development of chemo-resistance and is associated with tumor progression in many human malignancies [1]. Our previous study in melanoma demonstrated that the development of novel inhibitors targeting the redox regulation domain of APE/Ref-1 is a

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39

Ropke, Cristina Dislich. "Prevenção do dano fotooxidativo à pele por tratamento tópico com extrato da raiz de Pothomorphe umbellata L. Miq." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-26112015-143703/.

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Анотація:

Entre as estratégias de fotoproteção encontra-se a inibição da formação e/ou o seqüestro de radicais livres e espécies reativas de oxigênio geradas em conseqüência da exposição à radiação UV, mediante aplicação tópica de antioxidantes. No presente trabalho avaliou-se a permeação cutânea e o efeito da aplicação tópica de um extrato de Pothomorphe umbellata nos efeitos da exposição aguda e crônica à radiação ultravioleta, na pele de camundongos sem pêlo. No estudo de permeação cutânea foram testadas três formulações (gel, gel-creme e creme) contendo o princípio ativo do extrato (4-nerolidilcatec

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40

Amaro-Ortiz, Alexandra. "PHARMACOLOGIC INDUCTION OF THE MELANOCOTIN 1 RECEPTOR (MC1R) PATHWAY PROVIDES PROTECTION AGAINST SUNBURN AND ENHANCES EXPRESSION OF ANTIOXIDANT ENZYMES IN THE SKIN." UKnowledge, 2015. http://uknowledge.uky.edu/toxicology_etds/9.

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Анотація:

The inability to tan properly after sun exposure strongly correlates with increased incidence of skin cancer. The melanocortin 1 receptor (MC1R) is a transmembrane Gs-coupled cell surface receptor found on epidermal melanocytes that transmits pro-survival and pro-differentiation signals mediated by the second messenger cAMP. Humans carrying loss-of-function polymorphisms in MC1R signaling exhibit higher incidences of skin cancers including melanoma. This study focused on the physiologic effects of topical application of forskolin, an adenylate cyclase activator, in extension (Mc1re/e) K14-SCF

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41

Chamcheu, Jean Christopher. "Disease-causing Keratin Mutations and Cytoskeletal Dysfunction in Human Skin : In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123071.

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Epidermolysis bullosa simplex (EBS) and epidermolytic ichthyosis (EI) are rare skin fragility diseases characterized by intra-epidermal blistering due to autosomal dominant-negative mutations in basal (KRT5 or KRT14) and suprabasal (KRT1 or KRT10) keratin genes, respectively. Despite vast knowledge in the disease pathogenesis, the pathomechanisms are not fully understood, and no effective remedies exist. The purpose of this work was to search for keratin gene mutations in EBS patients, to develop in vitro models for studying EBS and EI, and to investigate novel pharmacological approaches for

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42

Jallal, Houda. "A Src-Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth and metastasis in vitro and in vivo /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112641.

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The central role of Src in the development of several malignancies including breast cancer and the accumulating evidence of its interaction with receptor tyrosine kinases (RTK), integrins and steroid receptors have identified it as an attractive therapeutic target. In the current study we have evaluated the effect of a Src/Abl kinase inhibitor SKI-606, on breast cancer growth, migration, invasion and metastasis. Treatment of human breast cancer cells MDA-MB-231 with SKI-606 caused a marked inhibition of cell proliferation, invasion and migration by inhibiting MAPK and Akt phosphorylation. For

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Blanchet, Sandrine. "Role des récepteurs nucléaires (RAR) de l'acide rétinoique au cours de la morphogenèse cutanée et dans les métaplasies induites par les rétinoides." Université Joseph Fourier (Grenoble), 1997. http://www.theses.fr/1997GRE10172.

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La peau des vertebres forme des annexes tegumentaires caracteristiques de chaque region du corps. L'apport ectopique d'acide retinoique tout-trans (ar-tt) provoque deux types de changements homeotiques de morphogenese (formation d'un type d'annexe en lieu et place d'un autre) : la formation de plumes sur les ecailles de la face anterieure du tarsometatarse chez le poulet et la formation de glandes en lieu et place des follicules pileux de vibrisse chez la souris. L'action de l'ar-tt s'exerce in vivo par l'intermediaire de deux classes de recepteurs nucleaires : les recepteurs de l'acide retino

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Touti, Rita. "Evaluation de la pénétration cutanée de principes actifs vétérinaires par l'utilisation d'outils spectrométriques." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0033.

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Les études de concentration et de distribution d’un principe actif dans la peau sont essentielles pour évaluer l’efficacité d’un médicament ou sa toxicité. Elles permettent d’étudier la biodisponibilité d’une molécule thérapeutique et d’étudier son profil pharmacocinétique. Dans ce mémoire, des techniques de spectrométrie ont été utilisées afin d’évaluer la pénétration cutanée de formulations thérapeutiques : l’imagerie Raman et MALDI. Ces techniques permettent d’obtenir des informations spatialement résolues par rapport aux méthodes de pharmacocinétique conventionnelles. Dans la première part

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Chen, Jie. "Understanding the mechanism of idiosyncratic drug reactions: Identification of the metabolic pathway leading to nevirapine-induced skin rash /." 2008. http://proquest.umi.com/pqdlink?did=1659961691&sid=3&Fmt=2&clientId=12520&RQT=309&VName=PQD.

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Singh, Suman K., Waqas A. Abbas, and Desmond J. Tobin. "Bone morphogenetic proteins differentially regulate pigmentation in human skin cells." 2012. http://hdl.handle.net/10454/6194.

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Bone morphogenetic proteins (BMPs) are a large family of multi-functional secreted signalling molecules. Previously BMP2/4 were shown to inhibit skin pigmentation by downregulating tyrosinase expression and activity in epidermal melanocytes. However, a possible role for other BMP family members and their antagonists in melanogenesis has not yet been explored. In this study we show that BMP4 and BMP6, from two different BMP subclasses, and their antagonists noggin and sclerostin were variably expressed in melanocytes and keratinocytes in human skin. We further examined their involvement in mela

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Lourenço, Ana Rita Nunes. "Administração tópica de fármacos : das restrições aos desafios." Master's thesis, 2013. http://hdl.handle.net/10437/4575.

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Orientação : Joana Portugal Mota<br>A pele é um órgão do corpo humano que apresenta diversas funções, sendo a sua principal característica actuar como barreira protectora. Esta é constituída por três camadas, sendo a mais externa a responsável pela sua principal função. A pele permite a administração de vários medicamentos como anti-inflamatórios, antifúngicos, antivíricos, entre outros, que podem ser utilizados quer a nível tópico (com recurso a cremes, géis, pomadas, etc) ou a nível sistémico, com recurso a sistemas transdérmicos. A via tópica apresenta como principal vantagem evitar o efei

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Antunes, Ana Filipa Valente. "Sistemas nanoparticulados aplicados à dermocosmética." Master's thesis, 2016. http://hdl.handle.net/10437/6832.

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Orientação : Catarina Pinto Reis<br>A administração cutânea de fármacos ou substâncias ativas apresenta vantagens em relação às vias de administração habitualmente utilizadas. Deste modo, tem surgido um interesse crescente no desenvolvimento de sistemas que permitem obter uma ação local ou sistémica. Todavia, apenas uma pequena fração da dose das substâncias atinge o tecido alvo, sendo que a maior parte é desperdiçada, devido à impermeabilidade parcial da pele. Destarte, várias estratégias foram desenvolvidas para melhorar a performance das substâncias, entre as quais encontram-se os sistema

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