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Дисертації з теми "Small Immunology"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 29 січня 2023

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1

Hosker, Harold Stephen Ronald. "Alveolar macrophage and blood monocyte function in small cell lung cancer." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241364.

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2

Leszczyńska, Katarzyna. "Signalling and function of the small Rho GTPase RhoJ in endothelial cells." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1495/.

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RhoJ is an endothelial expressed Rho GTPase, and its knock-down impairs endothelial cell (EC) migration and tubulogenesis, increases stress fibre (SF) and focal adhesion (FA) numbers. This work aimed to determine the intracellular localisation of RhoJ, identify its binding partners, test how it is activated and further explore its function in ECs. Endogenous RhoJ localised to FAs and overexpression of its active mutant (daRhoJ) promoted EC migration, and diminished FA and SF numbers. In addition to FAs, overexpressed RhoJ localised also to endosomes and RhoJ knock-down slightly delayed transfe

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3

Norville, Phillip. "Small colony variants in Staphylococcus aureus and other species : antibiotic selection, antimicrobial susceptibility, and biofilm formation." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/17713/.

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Staphylococcus aureus is one of the leading causes of hospital acquired infections. The ability of S. aureus to acquire resistance to a diverse range of antimicrobial compounds, results in limited treatment options, particularly in methicillin-resistant S. aureus. A mechanism by which S. aureus develops reduced susceptibility to antimicrobials is through the formation of small colony variants (SCVs). Reduced antimicrobial susceptibility in S. aureus SCVs is not related to ‘classical’ mechanisms of resistance, but occurs as a direct result of the development of the SCV phenotype. S. aureus SCVs

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4

Masjedi, Mohsen. "Physiological inflammation of the small intestine during weaning in the rat /." Title page, table of contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phm3973.pdf.

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5

Ismail, Jaidaa. "Testing BCL2A1 Small Molecule Inhibitors in Fluorescence Polarization Assays." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595846503840908.

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6

Chen, Xi. "Design and synthesis of small molecule inhibitors of coagulation FXIIa." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/53481/.

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Blood coagulation factors, factor XII (FXII), plasma kallikrein (PK), factor XI (FXI), and high-molecular-weight kininogen (HMWK), are four proteins that are involved in the plasma contact activation system (CAS) and kallikrein-kinin system (KKS). FXII is the initiation point of the intrinsic pathway of blood coagulation and is also the link between procoagulant and proinflammatory reactions. A number of inhibitors for blood coagulation factors have been approved for clinical usage. These inhibitors not only show inhibitory activities against thrombosis, but also disrupt haemostasis causing ex

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7

Hartlage, Alex S. "T CELL IMMUNITY IN A SMALL ANIMAL SURROGATE OF HEPATITIS C VIRUS INFECTION." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1584101091684162.

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8

Moghaddami, Mahin. "Characterization of isolated lymphoid aggregations in the mucosa of the small intestine /." Title page, abstract and contents only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phm6959.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1999.<br>Errata & addenda tipped in behind back end paper. Copies of author's previously published articles in pocket on back end-paper. Bibliography: leaves 147-194.

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9

Guo, Weihong, and 郭衛紅. "The immune mechanisms and novel immunosuppressive approaches in experimental small bowel transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3124175X.

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10

Jezierski, Anna W. "Crosstalk of E-cadherin and small GTPase Rap1 coordinates the clonality of human embryonic stem cells." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28089.

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Анотація:

Human embryonic stem cells (hESCs) are pluripotent cells, capable of giving rise to all three germ layers while maintaining their ability to proliferate indefinitely in culture. However, little is known regarding the microenvironmental cues that govern hESC self-renewal, particularly the challenge of clonal propagation following single cell dissociation. Increasing evidence suggests that intracellular pathways that coordinate E-cadherin-mediated cell-cell and integrin-mediated cell-ECM adhesions, are indispensable for the maintenance and self-renewal of hESCs. I have demonstrated that a potent

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11

Randrian, Violaine. "Role of myosin IIA in the small intestine immunosurveillance by dendritic cells." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB038/document.

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Plusieurs méthodes de capture antigénique ont été décrites dans l’intestin grêle, surtout en cas d’infection: échantillonnage direct par les cellules dendritiques (DC), capture par les macrophages qui délivrent ensuite l’antigène aux DC du stroma, passage des antigènes à travers les cellules caliciformes. Des travaux antérieurs in vitro dans le laboratoire ont montré l’importance de la myosine IIA dans la coordination de la migration des DC avec la capture et de l’apprêtement antigénique. L’objectif de ma thèse était de combiner plusieurs méthodes d’imagerie telle que la microscopie intravital

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12

Thompson, Fiona Marie. "Activation of the mucosal immune system and growth of the small intestine at weaning /." Title page, abstract and contents only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09pht4677.pdf.

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13

Lucera, Mark B. "Lysine Acetylation and Small Molecule Epigenetic Inhibition Reveal Novel Mechanisms Controlling Cellular Susceptibility to HIV-1 Infection." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448969829.

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14

Lu, Jingwei. "Development of Effective Immunotherapy for Ovarian Cancer Using Adoptive gamma-delta T Cells and Small Targeting Molecules." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366380793.

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15

Li, Xiaosong. "The mechanism study of novel approaches to control chronic allograft rejection in rat orthotopic small bowel transplantation." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36395778.

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16

Horwath, Michael C. "Changing the Fate of Histoplasma Capsulatum-infected Cells with Small Molecules: Investigation of Zinc Modifying Agents and the Antioxidant Ferrostatin-1." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin151635627882887.

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17

Corbet, Marlene. "Exploiting the helminth-derived immunomodulator, ES-62 and its small molecule analogues to dissect the mechanisms underpinning the development of the pathogenic phenotype of synovial fibroblasts in autoimmune arthritis." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8007/.

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Parasitic helminths are able to survive within their hosts due to their ability to dampen immune responses by secreting molecules with anti-inflammatory and tissue repair properties. Reflecting this, there is increasing evidence of an inverse correlation between parasitic worm infection and the incidence of allergic and autoimmune disorders on a global scale. Such epidemiological evidence has led to the “hygiene hypothesis” which postulates that the recent rapid eradication of parasitic worms in developed countries has resulted in unbalanced hyper-reactive immune systems and consequently, infl

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18

Li, Xiaosong, and 李小松. "The mechanism study of novel approaches to control chronic allograft rejection in rat orthotopic small bowel transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36395778.

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19

Gatbonton-Schwager, Tonibelle N. "Biological and Chemical Analysis of Small Molecule Activators of Anti-inflammatory and Antioxidant Nrf2-Keap1 Signaling." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1390560628.

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20

Koch, William J. "Initial Characterization of a Multifaceted Small Molecule and Its Efficacy for the Treatment of Type 1 Diabetes Mellitus." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1617098329334351.

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21

Charrier, Mélinda. "Caractérisation phénotypique et fonctionnelle de sous-populations Natural Killer (NK) chez des patients atteints d’un cancer bronchique non à petites cellules et impact d’une vaccination avec des exosomes de cellules dendritiques (Dex) autologues." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS438.

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Анотація:

Depuis peu, l’immunothérapie a émergé comme une nouvelle stratégie chez les patients atteint de Cancer Bronchique Non à Petites Cellules (CBNPC), confirmant ainsi le rôle du système immunitaire dans cette maladie. Malgré ces nouveaux traitements (thérapies ciblées, immunothérapie), les taux de réponses restent faibles avec un impact modeste sur la survie globale. Des biomarqueurs sont donc nécessaire pour définir les populations cibles de ces traitements. Une des pistes explorées est le statut immunitaire des patients, en effet celui-ci a un impact pronostic et pourrait influencer la réponse a

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22

Lemmey, Andrew Bruce. "Effects of insulin-like growth factors (IGFS) on recovery from gut resection in rats : a thesis submitted to the University of Adelaide, South Australia for the degree of Doctor of Philosophy." 1992, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phl554.pdf.

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Анотація:

Includes bibliographical references (leaves 159-213) Shows that IGF-I peptides are effective in diminishing post-surgical catabolism and enhancing adaptive gut hyperplasia in rats recovering from massive small bowel resection.

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23

Ou, Gangwei. "Human intestinal epithelial cells in innate immunity : interactions with normal microbiota and pathogenic bacteria." Doctoral thesis, Umeå : Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18388.

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24

Nistler, Ryan J. "Small RNA Regulation of the Innate Immune Response: A Role for Dicer in the Control of Viral Production and Sensing of Nucleic Acids: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/834.

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All organisms exist in some sort of symbiosis with their environment. The food we eat, air we breathe, and things we touch all have their own microbiota and we interact with these microbiota on a daily basis. As such, we employ a method of compartmentalization in order to keep foreign entities outside of the protected internal environments of the body. However, as other organisms seek to replicate themselves, they may invade our sterile compartments in order to do so. To protect ourselves from unfettered replication of pathogens or from cellular damage, we have developed a series of receptors

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25

Bloom, Connor. "The Feasibility of Whole-Blood-System Genotyping: A Case Study using the San Diego Blood Bank." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/cmc_theses/2110.

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Over the past several decades and increasingly in recent years, blood transfusions in the United States have plummeted as surgery has gotten more precise and less invasive. Alongside this decrease in general transfusions has been an increase in specific blood products for patients whose immune systems require special treatment. Simultaneously, trends in healthcare in the United States have incentivized regional hospitals to join large conglomerates. These coexisting factors have left regional blood banks, traditionally economically viable, in much weakened states. This thesis was born out of a

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26

Galvao, Flávio Henrique Ferreira. "Modelo experimental de doença do enxerto versus hospedeiro após transplante de intestino delgado." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-13072011-171433/.

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A doença do enxerto versus hospedeiro (DEVH) é uma grave complicação do transplante de órgãos sólidos, com alta mortalidade. Seu estudo tem sido limitado pela carência de modelos experimentais apropriados. Descreve-se um modelo de DEVH baseado no aumento do quimerismo, sua evolução clínica, histopatológica, do número das células quiméricas, do perfil das citocinas e da tolerância imunológica. Ratos Lewis (LEW) foram submetidos a transplante simultâneo de intestino delgado e medula óssea provenientes de ratos ACI (grupo de estudo - E) ou LEW (grupo controle - C), tratados com FK-506 (1 mg/Kg/di

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27

Perroud, Junior Mauricio Wesley 1971. "Avaliação de viabilidade, tolerância e segurança da vacina com células dendríticas autológas maduras em pacientes com carcinoma de pulmão não pequenas células avançado = Assessment of feasibility, safety and tolerance of mature autologous dendritic cells vaccine in patients with advanced non-small cell lung carcinoma." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310256.

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Анотація:

Orientador: Lair Zambon<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T10:28:19Z (GMT). No. of bitstreams: 1 PerroudJunior_MauricioWesley_D.pdf: 9913138 bytes, checksum: 5dd1ec64b004b6d50e2392e6383c9c98 (MD5) Previous issue date: 2012<br>Resumo: Os resultados terapêuticos globais do carcinoma de pulmão não pequenas células em estádio avançado são bem limitados. A imunoterapia com células dendríticas foi desenvolvida como uma nova estratégia para o tratamento de câncer de pulmão. O objetivo deste estudo foi aval

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28

Cerf-Bensussan, Nadine. "Etude des lymphocytes intraepitheliaux de l'intestin chez l'homme et le rat." Paris 7, 1987. http://www.theses.fr/1987PA077045.

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29

"Loss of LKB1 Leads to Alteration of the Immune Microenvironment in Non-Small Cell Lung Cancer." Master's thesis, 2015. http://hdl.handle.net/2286/R.I.29807.

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abstract: The majority of non-small cell lung cancer (NSCLC) patients (70%) are diagnosed with adenocarcinoma versus other histological subtypes. These patients often present with advanced, metastatic disease and frequently relapse after treatment. The tumor suppressor, Liver Kinase B1, is frequently inactivated in adenocarcinomas and loss of function is associated with a highly aggressive, metastatic tumor (1). Identification of the mechanisms deregulated with LKB1 inactivation could yield targeted therapeutic options for adenocarcinoma patients. Re-purposing the immune system to support tum

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30

Shaheen, Tanzia. "Screening lead small molecules for cytokine induction in a human whole blood assay informs candidate adjuvant selection." Thesis, 2018. https://hdl.handle.net/2144/31282.

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BACKGROUND: The human immune system is comprised of various cells that function to fight infection while also avoiding harmful inflammatory and autoimmune responses. The immune system consists of the innate and adaptive immune responses. While the adaptive immune response is involved in the late phase of infection and plays a role in generating classic T and B-cell based immunological memory, the innate immune response is the first line of defense and plays a role in early recognition of foreign substances and induction of an inflammatory response. Although the innate immune response is a natu

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31

Masjedi, Mohsen. "Physiological inflammation of the small intestine during weaning in the rat / by Mohsen Masjedi." Thesis, 1998. http://hdl.handle.net/2440/19349.

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Erratum is pasted onto back end-paper.<br>Bibliography: leaves 164-207.<br>xvii, 207, [26] leaves, [23] leaves of plates : ill. (chiefly col.) ; 30 cm.<br>Explores the hypothesis that physiological inflammation in the small intestine and the mesenteric lymph node is upregulated during the weaning period. Aims to determine changes in the number, phenotype, and activation status (using interleukin-2 receptor expression) of intraepithelial lymphocytes, lamina propria lymphocytes, mucosal mast cells, and mesenteric lymph node cells from preweaning to post weaning rats.<br>Thesis (Ph.D.)--Universit

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32

Thompson, Fiona Marie. "Activation of the mucosal immune system and growth of the small intestine at weaning / by Fiona Marie Thompson." Thesis, 1994. http://hdl.handle.net/2440/21494.

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Contains errata sheet in back pocket.<br>Bibliography: leaves 167-211.<br>xviii, 211, [8] leaves, [4] leaves of plates : ill. (some col.) ; 30 cm.<br>Explores the hypothesis that growth of the small intestine at weaning is promoted by an activated mucosal immune system in the gut. Tests by observing rats, guinea pigs and human infants.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1995?

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33

"Distribution and frequency of myeloid and t cell populations in the small intestine of newborn and weaned calves." Thesis, 2011. http://hdl.handle.net/10388/etd-07282011-105745.

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The development of mucosal dendritic cells (DCs) in cattle is poorly understood and an analysis of myeloid cells in the bovine small intestine is required to increase our knowledge in this area. The phenotype, frequency and distribution of mucosal myeloid and lymphoid lamina propria leukocytes (LPL) and intraepithelial leukocytes (IEL) in the ileum and jejunum of newborn calves (3-5 weeks old) were analyzed using flow cytometry and immunohistochemistry (IHC). LPL and IEL were isolated through the use of chemical and enzymatic incubations. Costaining with a CD45-specific monoclonal antibody all

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34

Katsman, Yulia. "Improved Mouse Models for the Study of Treatment Modalities using Sulfur-containing Small-molecular-Weight Molecules for Passive Immune-mediated Thrombocytopenia." Thesis, 2009. http://hdl.handle.net/1807/18786.

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Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by autoantibody-mediated platelet destruction. To test the efficacy of novel sulfur compounds as alternative treatments for ITP, we used a mouse model of passive immune thrombocytopenia (PIT). Using this model, the platelet nadir could not be maintained, with platelet counts rising after day 4, despite daily anti-platelet antibody administration. We examined reticulated platelet counts by flow cytometry, and found increased thrombopoiesis in the bone marrow to be at least partially responsible for this platelet reboun

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35

(8623374), Shishir Poudyal. "A COMBINED GENETIC AND CHIMERIC ANALYSIS OF THE FLAVIVIRAL NON-STRUCTURAL PROTEINS." Thesis, 2020.

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<p>A successful flaviviral life cycle involves several coordinated events between viral proteins and host factors. The polyprotein processing at the surface of the ER membrane results in the formation of several replication proteins that bring about changes in the ER membrane making it permissive for viral genome amplification. Non-structural proteins 4A (NS4A) and non-structural protein 4B (NS4B) are two of the most important integral membrane proteins of DENV that are essential part of the viral replicase complex. The cleavage at NS4A-2K-NS4B is temporally and spatially regulated. The cleava

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36

Lemmey, Andrew Bruce. "Effects of insulin-like growth factors (IGFS) on recovery from gut resection in rats : a thesis submitted to the University of Adelaide, South Australia for the degree of Doctor of Philosophy / by Andrew Bruce Lemmey." 1992. http://hdl.handle.net/2440/21638.

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Анотація:

xxiii, 222 leaves : ill., plates ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Shows that IGF-I peptides are effective in diminishing post-surgical catabolism and enhancing adaptive gut hyperplasia in rats recovering from massive small bowel resection.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Animal Science, 1992

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37

Cherukommu, Shirisha. "Role of GSK-3 and T-bet in anti-tumor immunity." Thesis, 2021. http://hdl.handle.net/1866/25645.

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Анотація:

Le facteur de transcription T-bet joue un rôle central dans la régulation de la différenciation des lymphocytes T. La protéine tyrosine kinase, la glycogène synthase kinase 3 (GSK-3), inhibe l'activation des lymphocytes T et contrôle l'expression de leurs récepteurs inhibiteurs PD-1 et LAG- 3. Bien que l'inhibition de GSK-3 puisse augmenter l'expression de T-bet, l'interrelation entre T-bet et GSK-3 dans l'immunité tumorale est inconnue. Dans cette étude, nous montrons que les souris knock-out T-bet (Tbet - / -) sont compromises dans leur capacité à contrôler la croissance des cellules tumoral

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38

Mwanthi, Muithi. "PAK1's regulation of eosinophil migration and implications for asthmatic inflammation." Thesis, 2013. http://hdl.handle.net/1805/3786.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>More than 300 million people world-wide suffer from breathlessness, wheezing, chest tightness, and coughing characteristic of chronic bronchial asthma, the global incidence of which is on the rise. Allergen-sensitization and challenge elicits pulmonary expression of chemoattractants that promote a chronic eosinophil-rich infiltrate. Eosinophils are increasingly recognized as important myeloid effectors in chronic inflammation characteristic of asthma, although few eosinophil molecular signaling pathways have successfully been targete

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