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Дисертації з теми "Somatomedin"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Bastian, Susan Elaine Putnam. "Transcellular transport of insulin-like growth factor-1 (IGF-1)." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phb3255.pdf.

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2

Bagley, Christopher James. "Analogues of Insulin-Like Growth Factor-1 / Christopher James Bagley." Title page, table of contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09phb146.pdf.

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3

Williams, Nolann G. "Myostatin regulation of the insulin-like growth factor axis." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Spring2009/n_williams_042009.pdf.

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Анотація:

Thesis (M.S. in genetics and cell biology)--Washington State University, May 2009.<br>Title from PDF title page (viewed on Apr. 5, 2010). "School of Molecular Biosciences." Includes bibliographical references (p. 39-45).

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4

Ramaswamy, Girish. "Mechanical and geometric characterization of mouse cortical bone with osteoblast-specific knockout of insulin-like growth factor receptor gene." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/ramaswamy.pdf.

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5

Diego, Vincent P. "Genotype x age interaction, and the insulin-like growth factor I axis in the San Antonio Family Heart Study a study in human senescence /." Diss., Online access via UMI:, 2005.

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6

Wilker, Erik William. "Role of insulin-like growth factor I in mouse skin tumor promotion /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3064687.

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7

Dodson, Michael Verne. "EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH FACTORS ON SATELLITE CELL PROLIFERATION IN VITRO (SOMATOMEDINS, RECEPTORS)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188065.

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Primary cultures of skeletal muscle satellite cells were induced to proliferate by exposure to physiologic levels of somatomedins and pharmacologic levels of insulin. Dexamethasone inclusion in serum containing medium facilitated the ovine somatomedin (oSm) (P < 0.05), but that both were different than the proliferation induced by MSA/rIGF-II (P < 0.05). In the presence of insulin concentrations that promote maximum proliferation, addition of oSm did not produce an additive effect, whereas the addition of MSA/rIGF-II did produce a significant increase in satellite cell proliferation above that

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8

Conlon, Michael Allan. "The effects of chronic IGF-I, IGF-II on long R3 IGF-I infusion on the postnatal growth of rats and guinea pigs." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phc7518.pdf.

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9

Thornton, William H. "The role of extracellular zinc in IGF-1 receptor expression and proliferation in a normal and squamous cell carcinoma cell line." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9946305.

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10

涂文偉 and Wenwei Tu. "Effects of insulin-like growth factor 1 on cord blood T cell development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31239377.

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11

Tu, Wenwei. "Effects of insulin-like growth factor 1 on cord blood T cell development /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2102893X.

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12

Walker, Gillian E. "The expression and regulation of human insulin-like growth factor-1 (IGF-1) during cellular growth, differentiation and tumourigenesis." Thesis, Queensland University of Technology, 1998. https://eprints.qut.edu.au/37002/8/37002_Digitised%20Thesis.pdf.

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Insulin-like growth factor (IGF) -I and -II play a significant role in determining a cell's fate, being involved in cellular growth and differentiation, tumourigenesis and as survival factors against apoptosis. These diverse biological actions of IGFs are mediated by their interaction with the type I IGF receptor (IGF-IR), with their availability to this receptor mediated by IGF binding proteins (IGFBPs) present within the extracellular compartments. The IGF-I and -II genes synthesise multiple mRNAs by alternate promoter usage and alternative splicing. This potentially contributes to the div

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13

Joseph, Suman C. "Allelic variations in the chicken insulin-like growth factor-I gene : effects on traits of economic importance in poultry." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35902.

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Due to the importance of insulin-like growth factor-I (IGF-I) in regulating many physiological and metabolic processes, the IGF-I gene was chosen as a candidate gene to study trait associated polymorphisms in chickens. A PstI restriction fragment length polymorphism (RFLP) was detected at the 5' region of the gene and mapped to about 7 Kb upstream of the published promoter sequence. Analysis for association of the marker with traits of economic importance in an unselected, random-bred population of 359 White Leghorns revealed a significant association with egg weight (P ≤ 0.05) and specific

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14

Brice, Amy L. "Growth factors and lipid transport in early mammalian development." Thesis, University of Oxford, 1990. http://ora.ox.ac.uk/objects/uuid:63dddafd-edd7-4c90-8b22-17b9ef81f96f.

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15

Kinhult, Anne. "Barramundi (Lates calcarifer) IGF-I : characterization of cDNA, genomic sequences, and regulation of mRNA expression." Thesis, Queensland University of Technology, 1996.

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16

Ohlsen, Susan M. "Cloning and characterization of ovine insulin, insulin-like growth factor-I and -II genes." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06062008-165729/.

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17

Stahlbom, Axel. "Characterisation of human IGF-I precursor prohormones : distinct function of IGF-IA and IGF-IB prohormones in the regulation of cellular growth." Thesis, Queensland University of Technology, 1996.

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18

Bode-Rhoads, Michelle Lynn. "Regulation of the growth hormone receptor, insulin-like growth factor (IGF) I and IGF binding protein 2 in reproductive tissues of dairy cattle during lactation and associated effects on fertility." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3164490.

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19

Gargosky, Sharron Erna. "Insulin-like growth factor (IGF) and IGF binding proteins during pregnancy in the rat and human /." Title page, table of contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phg2315.pdf.

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20

沈維華 and Weihua Shen. "Stability and absorption of milk-borne growth factors in the gastrointestinal tract of neonatal pigs." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237642.

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21

Ryder, Jeffrey W. "The effects of fasting and refeeding on insulin-like growth factor-I stimulated glucose transport." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1020146.

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Insulin-like growth factor-I (IGF-I) is a known stimulator of glucose transport. IGF binding protein 1 (IGFBP1) is a protein that regulates the actions of IGF-I by binding to IGF-I which alters it's ability to bind to the IGF-I receptor. Diet and exercise may influence this system. While IGFBP1 levels increase with fasting or prolonged exercise, feeding will reverse this elevation. The intent of this study was to determine if an in vivo manipulation of IGFBP1 affects in vitro glucose transport in the rat soleus. Sixteen male Spaque Dawley rats were fasted for 12 hours. Half of the animals were

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22

Kocamis, Hakan. "Functional profiles of growth related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2026.

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Анотація:

Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains ix, 109 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 88-104).

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23

Shen, Weihua. "Stability and absorption of milk-borne growth factors in the gastrointestinal tract of neonatal pigs /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19867943.

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24

Fild, Deborah S. "The effects of oral arginine supplementation on growth hormone, arginine, and somatomedin levels during energy restriction in male weight lifters." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-11242009-020056/.

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25

Ronge, Harald Dieter. "Investigations on somatomedin C and somatotropin in cattle : changes during pregnancy, parturition, lactation and growth, modified by energy and protein intake /." [S.l.] : [s.n.], 1989. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8772.

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26

Ankrapp, David P. "The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/39726.

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Анотація:

The concentration of insulin-like growth factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell lines (A549, A427, SK-LU-1) expressed the type I IGF-I receptor protein and IGF-I stimulated the proliferation of low density plated (2000 cells/cm² growth area) carcinoma cells by 1.6- to 3- fold above control after a four day inCUbation period under serum-free conditions

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27

Gao, Shan. "Screen for proteins that regulate sensitivity to inhibition of the insulin-like growth factor 1 receptor." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565965.

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The type 1 insulin-like growth factor receptor (lGF-1 R) plays a significant role in tumor growth and spread, and IGF-1 R inhibitors and antibodies are now undergoing clinical testing. However, factors that regulate sensitivity to IGF-1 R inhibition remain unclear. The aim of this project is to identify proteins whose depletion regulates sensitivity to IGF-1 R inhibition, in order to design effective combination treatments to benefit patients. An IGF-1 R kinase inhibitor, AZ12253801 (provided by AstraZeneca) was able to block IGF-induced phosphorylation of IGF-1 R in DU145 prostate cancer and

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28

Chui, Shiu Hon. "Biochemical and pharmacological effects of Chinese medicines on homocysteine and insulin-like growth factor-1 in health and in disease." HKBU Institutional Repository, 2004. http://repository.hkbu.edu.hk/etd_ra/539.

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29

Woll, Steven Cody. "Insulin-like Growth Factor Pathway Described in Austrofundulus limnaeus Diapause and Escape Embryos." PDXScholar, 2016. https://pdxscholar.library.pdx.edu/open_access_etds/3207.

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Development in the annual killifish Austrofundulus limnaeus can follow two distinct developmental trajectories. Typical development includes the entrance of embryos into a state of metabolic and developmental arrest termed diapause. Alternately, embryos can escape diapause and develop directly without pause. These two trajectories are characterized by differences in the rate and timing of developmental, morphological, and physiological traits. Insulin and Insulin-like growth factor (IGF) signaling (IIS) is known to regulate entrance into diapause in a variety of invertebrates. In this thesis I

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30

Marshall, Nicholas John. "The influence of insulin-like growth factor 1 and its analogues on fibroblasts and dermal wound healing." Title page, table of contents and synopsis only, 1998. http://web4.library.adelaide.edu.au/theses/09MD/09mdm3685.pdf.

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Includes bibliography (leaves 191-219). Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in vivo at the wound s

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31

Obese, Frederick Yeboah. "Concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) in the plasma and milk of pasture-fed dairy cows in early lactation /." Connect to thesis, 2003. http://eprints.unimelb.edu.au/archive/00000549.

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32

Foster, Ernest Byron Pascoe David D. "Acute regulation of IGF-1 by differential growth-factor-binding-protein expression, inhibition, and proteolysis." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Health_and_Human_Performance/Dissertation/Foster_Ernest_45.pdf.

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33

Durrer, Katherine Elaine. "Impact of a Genetically Engineered Probiotic Therapy and IGF-1 Genomics in the PAHenu2 Mouse Model of PKU." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822730/.

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Absence of functional phenylalanine hydroxylase results in phenylketonuria (PKU). Viable treatments remain few, expensive and secondary conditions such as osteopenia occur in most PKU patients. Objective 1: Given the recently described roles of gut microbes to aid host digestion, an orally administered genetically engineered probiotic as the delivery vehicle for enzyme replacement therapy was created. The engineered probiotic, pHENOMMenal, produced phenylalanine ammonia lyase with significant production of trans-cinnamate (phenylalanine cleavage product) in vitro and resulted in a reduction

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34

Hack, Nicole L. "The Insulin-Like Growth Factor-1 (IGF1) System as a Potential Biomarker for Nutritional Status and Growth Rate in Pacific Rockfish (SEBASTES SPP.)." DigitalCommons@CalPoly, 2017. https://digitalcommons.calpoly.edu/theses/1824.

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Growth performance in vertebrates is regulated by environmental factors including the quality and quantity of food, which influences growth via endocrine pathways such as the growth hormone (GH) / insulin-like growth factor somatotropic axis. In several teleost fishes, circulating concentrations of insulin-like growth factor-1 (Igf1) correlate positively with growth rate, and it has been proposed that plasma Igf1 levels may serve as an indicator of growth variation for fisheries and aquaculture applications. Here, I tested whether plasma Igf1 concentrations might serve as an indicator of somat

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35

Kobayashi, Yasuhiro. "Changes in the activity of growth hormone receptor promotor 1 in liver of cattle /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9974648.

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36

Kind, Karen Lee. "Insulin-like growth factors and growth of the fetal sheep /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phk525.pdf.

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37

Cheung, Catherine Wing Ying. "IGF family members in renal cell carcinoma : their roles in malignancies and therapeutic interventions /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18766.pdf.

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38

Farhat, Antoine G. "Growth and IGF-I response to breast muscle selection by ultrasound and dietary protein programs in Pekin ducks." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ55327.pdf.

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39

Long, Ezhou. "Involvement of insulin-like growth factor I and its binding proteins on proliferation and differentiation of murine bone marrow macrophage precursors." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27371.

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The alteration of insulin-like growth factor I (IGF-I) and its binding proteins (IGFBP) and their effects on proliferation and differentiation of murine bone marrow-derived macrophage (BMM) precursors were investigated. Bone marrow cells exposed to 20% L929-fibroblast conditioned medium (LCM) were cultured in serum-free medium for 24 h. Western ligand blotting (WLB) analysis detected four bands in all samples. 41-kDa and 30-kDa bands were detected after 12 h and remained constant during BMM differentiation. The 28-kDa and 25-kDa proteins were almost undetectable until day 2, but accumulated si

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40

Yuen, John Shyi P. "The role of the type 1 insulin-like growth factor receptor (IGF1R) in renal cancer." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670113.

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41

Bischler, Troy K., and University of Lethbridge Faculty of Arts and Science. "The utility of resting levels of IGF-I and IGFBP-3 as markers of training status in elite athletes." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, c2007, 2007. http://hdl.handle.net/10133/651.

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Insulin-like growth factor-I (IGF-I) and its principle binding protein (IGFBP-3) are believed to play a role in mediating the anabolic effects of exercise. The purpose of this study was to assess the effect of 4 months of training on IGF-I and IGFBP-3, and to determine if changes in IGF-I or IGFBP-3 were related to changes in training status. Twelve varsity swimmers (5 males, 7 females) were tested pre-season, and again after 8 and 16 weeks of training. Measures included: VO2 max, nutritional status, athletic performance, subjective symptoms of overtraining, and serum levels of IGF-I and IGFBP

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42

Takiguchi, Megumi. "The function of the type 1 insulin-like growth factor receptor (IGF1R) in intestinal tumorigenesis." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670044.

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43

Dobbins, Adam Bradley. "Potential mechanisms linking nutrition and neuroendocrine control of reproduction in the sheep." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3615.

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Thesis (M.S.)--West Virginia University, 2004.<br>Title from document title page. Document formatted into pages; contains iv, 124 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 82-124).

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44

Maquart, François-Xavier. "Regulation de la synthese de collagene et de la proliferation des fibroblastes par des effecteurs extracellulaires." Reims, 1987. http://www.theses.fr/1987REIMS013.

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Les effets de 4 types d'effecteurs (glucose, somatomedine a, glycoproteines de structure extraites du tissu conjonctif normal et de triterpenes extraits de centella asiatica) sur la synthese du collagene ou la proliferation cellulaire ont ete etudies dans des cultures de fibroblastes dermiques. Le glucose inhibe la proliferation fibroblastique. La somatomedine a induit une orientation preferentielle des mecanismes de synthese proteique vers la production de proteine intracellulaires avec une retention de procollogene. Un effet inhibiteur de certaines molecules sur la synthese de proteines tota

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45

Van, Renen Margaret Jean. "Effects of GH on the IGF's and IGFBP's in children with chronic renal failure and transplantation /." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09MD/09mdv274.pdf.

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46

FROMMER, PATRICIA. "La somatomedine-c comme mediateur biologique et marqueur nutritionnel." Strasbourg 1, 1991. http://www.theses.fr/1991STR15016.

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47

Doyle, Kharen Leigh. "The control of insulin-like growth factor-1 (IGF-1) in the spinal cord of the rat." Thesis, Queensland University of Technology, 1999.

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48

NEGRE, FLORENCE. "Retinopathie diabetique proliferative et somatomedine c : etude clinique et immunohistochimique." Nice, 1990. http://www.theses.fr/1990NICE6806.

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49

Degger, Brian. "Fish insulin-like growth factors : their role in growth from a functional perspective." Thesis, Queensland University of Technology, 2001.

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50

VERCOUTERE, FREMAUX LUCILE. "Place du dosage de la somatomedine c dans l'insuffisance staturale chez l'enfant." Reims, 1990. http://www.theses.fr/1990REIMM072.

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