Готові списки джерел за темами / Sonodynamic photodynamic therapy

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Добірка наукової літератури з теми "Sonodynamic photodynamic therapy"

Автор: Grafiati

Опубліковано: 10 січня 2023

Оновлено: 28 січня 2023

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Статті в журналах з теми "Sonodynamic photodynamic therapy"

Zhu, Shuang, De-Qiang Wang, Xue-Hua Sun, Xin-Yu Li, Hui-Fang Xiao, Wan-Ru Sun, Xing-Tao Wang, et al. "Mitochondria-Targeted Degradable Nanocomposite Combined with Laser and Ultrasound for Synergistic Tumor Therapies." Journal of Biomedical Nanotechnology 18, no. 3 (March 1, 2022): 763–77. http://dx.doi.org/10.1166/jbn.2022.3287.

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Although the development of safe and efficient cancer therapeutic agents is essential, this process remains challenging. In this study, a mitochondria-targeted degradable nanoplatform (PDA–MnO2-IR780) for synergistic photothermal, photodynamic, and sonodynamic tumor treatment was investigated. PDA–MnO2-IR780 exhibits superior photothermal properties owing to the integration of polydopamine, MnO2, and IR780. IR780, a photosensitizer and sonosensitizer, was used for photodynamic therapy and sonodynamic therapy. When PDA–MnO2-IR780 was delivered to the tumor site, MnO2 was decomposed by hydrogen peroxide, producing Mn2+ and oxygen. Meanwhile, alleviating tumor hypoxia promoted the production of reactive oxygen species during photodynamic therapy and sonodynamic therapy. Moreover, large amounts of reactive oxygen species could reduce the expression of heat shock proteins and increase the heat sensitivity of tumor cells, thereby improving the photothermal treatment effect. In turn, hyperthermia caused by photothermal therapy accelerated the production of reactive oxygen species in photodynamic therapy. IR780 selectively accumulation in mitochondria also promoted tumor apoptosis. In this system, the mutual promotion of photothermal therapy and photodynamic therapy/sonodynamic therapy had an enhanced therapeutic effect. Moreover, the responsive degradable characteristic of PDA–MnO2-IR780 in the tumor microenvironment ensured excellent biological safety. These results reveal a great potential of PDA–MnO2-IR780 for safe and highly-efficiency synergistic therapy for cancer.

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Son, Subin, Ji Hyeon Kim, Xianwen Wang, Chuangli Zhang, Shin A. Yoon, Jinwoo Shin, Amit Sharma, et al. "Multifunctional sonosensitizers in sonodynamic cancer therapy." Chemical Society Reviews 49, no. 11 (2020): 3244–61. http://dx.doi.org/10.1039/c9cs00648f.

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Rengeng, Liu, Zhang Qianyu, Lang Yuehong, Peng Zhongzhong, and Li Libo. "Sonodynamic therapy, a treatment developing from photodynamic therapy." Photodiagnosis and Photodynamic Therapy 19 (September 2017): 159–66. http://dx.doi.org/10.1016/j.pdpdt.2017.06.003.

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Tzerkovsky, D. A., E. L. Protopovich, and D. S. Stupak. "Sonodynamic and sono-photodynamic therapy in oncology." Biomedical Photonics 8, no. 2 (July 10, 2019): 31–46. http://dx.doi.org/10.24931/2413-9432-2019-8-2-31-46.

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In the present publication, authors have analyzed the results of using sonodynamic and sono-photodynamic therapy with photosensitizing agents of various classes (hematoporphyrin, 5-aminolevulinic acid, chlorin derivatives, etc.) in experimental oncology. In a number of in vitro and in vivo studies, the high antitumor efficacy of the above treatment methods has been proven. Ultrasonic treatment with a pulse frequency of 1–3 MHz and an intensity of 0.7 to 5 W/cm2 , independently and in combination with photo-irradiation of experimental tumors, can significantly improve the cytotoxic properties of photosensitizers. This became the basisfor testing the methodsin patients with malignant neoplasms of various localizations. Scientists fromSouth-East Asia presented the preliminary results of the use of sonodynamic and sono-photodynamic therapy with photosensitizers in the treatment of malignant pathology of the mammary gland, stomach, esophagus, prostate, lung and brain. Analysis of the obtained data indicates the absence of serious adverse events and an increase in the antitumor efficacy of treatment, which included these treatment methods with chlorin-type photosensitizers.

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Luo, Hongyu, Wenmei Yu, Si Chen, Zhenyu Wang, Zejie Tian, Jun He, and Yunmei Liu. "Application of metalloporphyrin sensitizers for the treatment or diagnosis of tumors." Journal of Chemical Research 46, no. 2 (March 2022): 174751982210909. http://dx.doi.org/10.1177/17475198221090914.

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At present, metalloporphyrin compounds demonstrate three main uses as anticancer sensitizers: (1) photosensitizers, (2) photothermal conversion agents, and (3) ultrasound sensitizers. Developing efficient sensitizers for cancer with excellent controllability and biocompatibility is an important goal of oncology medicine. Because of the different structural diversity of anticancer sensitizers, such sensitizers are used for treating cancers by employing a variety of tumor treatment methods such as mature photodynamic therapy, commonly used clinically photothermal therapy and promising sonodynamic therapy. Among the many sensitizers, metalloporphyrin-complex sensitizers attract wide attention due to their excellent performance in tumor treatment and diagnosis. This review briefly describes some metalloporphyrin anticancer drugs and diagnostic agents related to photodynamic, photothermal and sonodynamic therapy, and discusses the roles of metal atoms in these drugs.

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Songca, Sandile Phinda, and Yaw Adjei. "Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms." International Journal of Molecular Sciences 23, no. 6 (March 16, 2022): 3209. http://dx.doi.org/10.3390/ijms23063209.

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Antimicrobial photodynamic therapy and allied photodynamic antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic and biofilm forms. There has been little or no resistance development against antimicrobial photodynamic therapy. Furthermore, recent developments in therapies that involve antimicrobial photodynamic therapy in combination with photothermal hyperthermia therapy, magnetic hyperthermia therapy, antibiotic chemotherapy and cold atmospheric pressure plasma therapy have shown additive and synergistic enhancement of its efficacy. This paper reviews applications of antimicrobial photodynamic therapy and non-invasive combination therapies often used with it, including sonodynamic therapy and nanozyme enhanced photodynamic therapy. The antimicrobial and antibiofilm mechanisms are discussed. This review proposes that these technologies have a great potential to overcome the bacterial resistance associated with bacterial biofilm formation.

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Weber, M. "New Developments in Photodynamic and Sonodynamic Cancer Therapy." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 222s. http://dx.doi.org/10.1200/jgo.18.89900.

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Background: Photodynamic therapy (PDT) is already widely used for the treatment of superficial tumors. Due to technological developments in the field of low-level laser therapy it can now also be used to treat various kinds of internal cancers, including breast, lung, prostate, bladder, rectal and other cancers. The principle is the photoactivation of a light sensitive substance (photosensitizer) which is injected into the bloodstream or directly into the tumor. After a certain amount of time the photosensitizer will be taken up by cancer cells by endocytosis. The cancerous area is then irradiated by laser light of appropriate wavelength, according to the absorption spectra of the photosensitizer. The emitted photons are absorbed by the photosensitizer which is thereby shifted to a highly reactive state. As a consequent, it interacts with tissue oxygen, leading to the development of reactive singlet oxygen radicals which are cytotoxic for cancer cells. Additional sonodynamic cancer therapy (SDT) improves the clinical outcomes. Aim: We describe a broad number of case studies to demonstrate the outstanding potential of the treatment protocols. Methods: We used indocyanine green, curcumin and hypericin as photosensitizing agents. Upon light activation, the agents react with oxygen, leading to the development of oxygen radicals which induce irreparable damage on cancer cells. Results: In the vast majority of all cases, significant reductions of tumor mass up to complete remissions could be achieved. Conclusion: Protocols consisting of photodynamic and sonodynamic cancer therapies have the potential to become mainstream cancer therapies in the next couple of years.

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Norman Kenyon, Julian, and Richard James Fuller. "Outcome Measures Following Sonodynamic Photodynamic Therapy – A Case Series." Current Drug Therapy 6, no. 1 (February 1, 2011): 12–16. http://dx.doi.org/10.2174/157488511794079059.

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Wang, Xiaohuai, Lucy Qing Li, Weimin Zhang, Yifan Luo, and Douglas Graham Mitchell. "Sonodynamic and photodynamic therapy in advanced refractory breast cancer." Journal of Clinical Oncology 30, no. 27_suppl (September 20, 2012): 118. http://dx.doi.org/10.1200/jco.2012.30.27_suppl.118.

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118 Background: Sonodynamic therapy (SDT), a procedure related with photodynamic therapy, is a promising new modality for treating deep-seated cancer. Two new chlorophyll derived sono-photo-sensitizing agents, along with equipment for systemic SDT, have been developed by EEC Biotech and all approved by regulator for safety on human. Animal studies demonstrate that the sensitizers are specifically absorbed into tumor cells and SDT does inhibit growth of mouse S-180 sarcoma. An in vitro experiment with human breast cancer cell-line showed that SDT was strongly synergetic with chemotherapy. Using sono-photo-dynamic therapy (SPDT) as a supplementary or salvage treatment, we have got some positive results in advanced refractory breast cancers. Methods: Twelve patients were pathologically proven advanced breast carcinoma. Eleven had metastases in viscera including brain, and nine in bones. Ten had chemotherapy before, nine failed at least second lines of conventional chemotherapy. With SPDT, Patients took the sensitizers sublingually on days 1 and 2, red light and multiple ultrasound transducers irradiate tumor area and whole body on days 4 to 6. The treatment was repeated. Nine patients had concurrent chemo with range from moderate to ¼ conventional dosages selected to keep side effects at grade II or better. Results: The twelve patients achieved CR 3(25%), PR 6 (50%), MR 1, SD 2, with an overall response rate of 75%.Median overall survival exceeded 14.5 months. SPDT as sole therapy was effective in three cases. Four treated repeatly with SPDT also achieved positive result after tumor relapsed. One patient with brain metastases showed much reduced. The two SD were TNBC with inflammation-like metastases on the chest surface. The main SPDT side effects were easily reversible mild pain in tumor areas, tiredness and weakness.There was no skin sensitivity.SPDT/dose controlled chemo was well tolerated, even a terminally ill patient was treated safely and effectively. Conclusions: These preliminary data suggest that SPDT has almost no toxicity, and may dramatically enhance chemo efficacy in some refractory advanced breast cancer cases. SPDT has a good trend to be a new systemic, low toxicity tumor therapy and merit for further investigation.

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Stride, Eleanor P. "Probing the mechanisms of sonodynamic therapy." Journal of the Acoustical Society of America 151, no. 4 (April 2022): A39. http://dx.doi.org/10.1121/10.0010585.

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Drugs that can be activated by a physical stimulus at a target site offer great potential for limiting toxic side effects, e.g., in cancer therapy. In photodynamic therapy, light is used as the stimulus, but clinical applications are limited due to the poor penetration of light in tissue. Multiple studies have demonstrated that ultrasound can also be used to activate some light-responsive drugs. This potentially extends the range of therapeutic applications considerably, but the mechanisms underpinning drug activation, dubbed sonodynamic therapy (SDT), remain unclear. It was recently demonstrated that multi-bubble sonoluminescence could be detected from a suspension of microbubble ultrasound contrast agents when exposed to ultrasound under conditions similar to those used in SDT. Moreover, the addition of an SDT drug produced a reduction in optical emissions at the wavelength corresponding to its activation. Numerous questions, however, remain and the aim of this talk is to review recent studies of SDT and new evidence for the roles of sonoluminescence, sonoporation, and other phenomena hypothesized to play a role in its mechanism of action.

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Більше джерел

Дисертації з теми "Sonodynamic photodynamic therapy"

Fowley, Colin Paul. "Nano/micro particle conjugates for use in photodynamic and sonodynamic therapy." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692835.

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Photodynamic therapy (PDT) has been used as a clinical treatment since the early 1990s and utilizes a photosensitising drug (PS), molecular oxygen and light of a specific wavelength, (usually visible light below 700nm) to generate singlet oxygen and other reactive oxygen species which are highly cytotoxic. Originally used as a treatment for superficial skin cancer it is now emerging as a treatment for other forms of cancer such as head, neck, lung and prostate cancers. There are however, several limitations which have prevented PDT obtaining wide spread clinical use. For example currently approved PS drugs absorb light in the visible region limiting tissue depth penetration to a few mm rendering the treatment unsuitable for deep seated tumours. Secondly, PS molecules also tend to be hydrophobic and can aggregate in aqueous solutions, leading to a reduction in singlet oxygen production. The focus of this PhD seeks to take advantage of the photophysical properties of conventional cadmium selenide quantum dots (QDs) (chapter 3) and the relatively new carbon based nano material known as carbon quantum dots (CQDs) (chapter 4), to address some of the difficulties currently faced with the use of conventional PS drugs in PDT. This strategy shall involve the synthesis, in vitro and in vivo evaluation of suitable nano-particlePS conjugates. In addition to the synthesis of conjugates for PDT implications, microbubblesensitiser conjugates were also developed for use in sonodynamic therapy (SDT). SDT refers to the ultrasound dependent cytotoxic effect of certain compounds (sonosensitisers). Ultrasound having far superior tissue dept penetration than light, overcoming the major limitation of poor tissue depth penetration observed in PDT. However there are still some undesirable characteristics associated with SDT. The accumulation of sonosensitisers in healthy tissue has been one such drawback, as sonosentisers (SS) are generally also PS this can lead to photosensitivity of the skin. In order to achieve a greater degree of selectivity the use of microbubble-SS conjugates was investigated (chapter 5). Lipid based microbubbles (MBs) are currently approved for use as contrast agents in diagnostic ultrasound applications and have also been investigated as potential drug / gene delivery vehicles. In chapter 5 Rose Bengal, a well known SS, was covalently attached to the surface of a lipid coated MB. The overall objective of this strategy was to investigate the potential of this MB-SS conjugate as a therapeutic for highly targeted, minimally invasive treatment of deep seated tumours.

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Wijesiri, Niranga H. "Development of Nanoparticle – Based Hybrid Sensitizers for Therapeutic Applications." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593273291966287.

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Lee, Daniel. "Analysis and Assessment on Effects of Different Therapies in Cancer Treatment Based on Fuzzy Cognitive Maps." Thesis, 2019. https://vuir.vu.edu.au/41295/.

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Cancer is the second leading cause of death worldwide. Even though cancer death rates have slightly decreased in the last decades, the painful experience of cancer diagnosis and treatment still occurs every day globally. It is critically important to develop advanced computing technologies to better understand the effectiveness and management of cancer treatment. Nevertheless, most of the present tools for analysis and assessment therapy effects in cancer treatment are based on immediate relative factors and laboratory reports. The causal relationship of the key factors is not recorded or modelled, thus not analysed and communicated effectively. Fuzzy cognitive map (FCM), as a medical decision support tool, has been applied in medical practice and overall appreciated in recent decades. In this thesis, clinical cancer cases were analysed and assessed with the help of FCM. It is particularly applied to visualise the knowledge and experience about effects of different types of therapies, including the alternative therapies of sonodynamic and photodynamic therapy and traditional Chinese medicine modalities. Through the cases study with the help of FCM, the model can clearly show that the effects or outcomes of cancer treatments are critically influenced by the causally related factors. The analysis and assessment results demonstrated that FCMs can visually represent the cognitive knowledge, particularly the causal relationship among key factors in the combination of different cancer therapies, while the individuals’ causal influence factors showing certain degrees of capability for driving different effective outcomes. This modelling will enable further analysis and communication of the rationales of different intervention or decision makings from different practitioners and specialists.

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Частини книг з теми "Sonodynamic photodynamic therapy"

Lopes de Mello, Heber, Luiz Anastacio Alves, Evellyn Araujo Dias, Sabrina de Sá Pereira Magalhães, Vinicius Cotta-de-Almeida, and Rodrigo da Cunha Bisaggio. "Sonodynamic and Photodynamics Used as a Combined Therapy in the Treatment of Malignant Neoplasms: Facts and Open Questions." In Photodynamic Therapy - from Basic Science to Clinical Research [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94600.

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Photodynamic therapy (PDT) used in combination with sonodynamic therapy (SDT) is a new approach that aims to increase the effectiveness of tumor treatment when compared to the effect of each independent therapy. PDT is based on stimulating sensitizers with photons, while the most accepted theory for SDT is that sensitizers are stimulated by the sonoluminescence phenomenon. However, after the excitation of the sensitizer, both therapies follow a common path, leading to the generation of free radicals and inducing cell death. One of the positive aspects of this combination is the augmentation of anti-tumor activity with fewer side effects, since cell death may be induced using lower sensitizer concentrations or less exposure to ultrasound or light. Another benefit of combining PDT and SDT, especially with the use of low-frequency ultrasound is the induction of sonophoresis. For instance, on the skin, it may facilitate the absorption of the sensitizer. However, research involving both PDT and SDT exhibit many variants, including differences in irradiation sources and their intensities, among others. These aspects contribute to a lack of standardization, leading to result variations, hindering assessment on the real contribution that these combined therapies can offer in tumor treatment. Thus, further research in the pre-clinical and clinical areas are crucial.

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Тези доповідей конференцій з теми "Sonodynamic photodynamic therapy"

Drantantiyas, Nike Dwi Grevika, Suryani Dyah Astuti, and Aulia M. T. Nasution. "Comparison microbial killing efficacy between sonodynamic therapy and photodynamic therapy." In Second International Seminar on Photonics, Optics, and Its Applications (ISPhOA 2016), edited by Agus M. Hatta and Aulia M. T. Nasution. SPIE, 2016. http://dx.doi.org/10.1117/12.2248503.

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Lam, Kit S., Yuanpei Li, Tzu-yin Lin, Hongyong Zhang, Caihong Feng, Yan Luo, Chong-Xian Pan, et al. "Abstract 4508: Novel multifunctional nanocarriers for drug delivery, photodynamic therapy, sonodynamic therapy, MRI and PET imaging." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4508.

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