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Статті в журналах з теми "Specialized ribosome":
Guo, Huili. "Specialized ribosomes and the control of translation." Biochemical Society Transactions 46, no. 4 (July 9, 2018): 855–69. http://dx.doi.org/10.1042/bst20160426.
Barna, Maria. "Specialized Ribosomes: A New Frontier in Gene Regulation, Organismal Biology, & Evolution." Blood 128, no. 22 (December 2, 2016): SCI—41—SCI—41. http://dx.doi.org/10.1182/blood.v128.22.sci-41.sci-41.
Chaillou, Thomas. "Ribosome specialization and its potential role in the control of protein translation and skeletal muscle size." Journal of Applied Physiology 127, no. 2 (August 1, 2019): 599–607. http://dx.doi.org/10.1152/japplphysiol.00946.2018.
Mageeney, Catherine M., and Vassie C. Ware. "Specialized eRpL22 paralogue-specific ribosomes regulate specific mRNA translation in spermatogenesis in Drosophila melanogaster." Molecular Biology of the Cell 30, no. 17 (August 2019): 2240–53. http://dx.doi.org/10.1091/mbc.e19-02-0086.
Dalla Venezia, Nicole, Anne Vincent, Virginie Marcel, Frédéric Catez, and Jean-Jacques Diaz. "Emerging Role of Eukaryote Ribosomes in Translational Control." International Journal of Molecular Sciences 20, no. 5 (March 11, 2019): 1226. http://dx.doi.org/10.3390/ijms20051226.
Baudin-Baillieu, Agnès, and Olivier Namy. "Saccharomyces cerevisiae, a Powerful Model for Studying rRNA Modifications and Their Effects on Translation Fidelity." International Journal of Molecular Sciences 22, no. 14 (July 10, 2021): 7419. http://dx.doi.org/10.3390/ijms22147419.
Leclerc, Daniel, and Léa Brakier-Gingras. "Study of the function of Escherichia coli ribosomal RNA through site-directed mutagenesis." Biochemistry and Cell Biology 68, no. 1 (January 1, 1990): 169–79. http://dx.doi.org/10.1139/o90-023.
Kampen, Kim R., Sergey O. Sulima, Stijn Vereecke, and Kim De Keersmaecker. "Hallmarks of ribosomopathies." Nucleic Acids Research 48, no. 3 (July 27, 2019): 1013–28. http://dx.doi.org/10.1093/nar/gkz637.
Wang, Xiangxiang, Zhiyong Yue, Feifei Xu, Sufang Wang, Xin Hu, Junbiao Dai, and Guanghou Zhao. "Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans." Nucleic Acids Research 49, no. 8 (April 6, 2021): 4655–67. http://dx.doi.org/10.1093/nar/gkab218.
Skorski, Patricia, Prune Leroy, Olivier Fayet, Marc Dreyfus, and Sylvie Hermann-Le Denmat. "The Highly Efficient Translation Initiation Region from the Escherichia coli rpsA Gene Lacks a Shine-Dalgarno Element." Journal of Bacteriology 188, no. 17 (September 1, 2006): 6277–85. http://dx.doi.org/10.1128/jb.00591-06.
Дисертації з теми "Specialized ribosome":
Hebras, Jade. "Caractérisation moléculaire du petit ARN nucléolaire SNORD115 : un rôle dans la régulation de l'expression et de la fonction du récepteur à la sérotonine 5-HT2C ?" Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30209.
The nucleolus of mammalian cells contains hundreds of box C/D small nucleolar RNAs (SNORDs). Majority of them, guide sequence-specific 2'-O ribose methylations into ribosomal RNA (rRNA). Some of them facilitate RNA folding and cleavages of ribosomal RNA precursors or guide ribose methylations into spliceosomal small nuclear RNA U6. Recent studies propose that some SNORD could target other transcripts, possibly messenger RNA as suggested by the brain-specific SNORD115. SNORD115 is processed from tandemly repeated genes embedded in the imprinted SNURF-SNRPN domain. Defects in gene expression at this domain are causally linked to rare disease: the Prader-Willi Syndrome (PWS). Excitingly, SNORD115 displays an extensive region of complementary to a brain-specific mRNA encoding the serotonin receptor 5-HT2C. SNORD115 could influence 5-HT2C signaling by fine-tuning alternative splicing or A to I RNA editing of 5-HT2C pre-mRNA. Reduced 5-HT2C receptor activity could contribute to impaired emotional response and/or compulsive overeating that characterized the syndrome. My work was to test this hypothesis using a CRISPR/Cas9-mediated SNORD115 knockout mouse model. My results show that loss of SNORD115 expression, in vivo, does not alter the post-transcriptional regulation of 5-HT2C pre-mRNA processing. Others results from the team do not reveal any defects in anxio-depressive phenotypes and eating behaviour. Our study questions the regulatory roles of SNORD115 in brain functions and behavioural disturbance associated with PWS. On other hand, I have studied ribose methylation sites in rRNA from mouse tissues. This work was included in emerging field of the specialized ribosome hypothesis which suggests heterogeneity in ribosomes may impact activity of ribosomes. Our results show significant changes at few discrete set of sites, especially in rRNA from developing tissues. Also, rRNA from developing tissues is globally less methylated than rRNA from adult tissues. We focus on LSU-Gm4593 site because this position is specifically methylated only during development and hardly ever detected in adult tissues. Methylation at LSU-G4593 is guided by SNORD78. We propose that the expression levels of SNORD78 during development appeared to be regulated by alternative splicing of the host-gene and to correlate with the methylation level of its target site at LSU-G4593. We've used a human cell line (HEK293T) inactivated for the SNORD78 gene in order to understand the functionally role of the corresponding ribose methylation. Our work did not demonstrate any overt cellular phenotypes, even though translation fidelity and the precise function of LSU-Gm4593 remains unknown
Meyer, Alison E. "Characterization of the specialized role of the ribosome-associated J-protein, Jjj1, in ribosome biogenesis /." 2009. http://www.library.wisc.edu/databases/connect/dissertations.html.
Lizaso, Analyn, and 饒安麗. "Role of Specialized Ribosomal Protein Genes in the Responseto Starvation Stress in the Male C.elegans." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/d65477.
國防醫學院
生命科學研究所
101
In general, the survival of an organism, such as human, is highly dependent on its ability to respond to constant environmental and metabolic stresses such as drought and famine. Metabolic adaptations include the ability to store excess energy as fat during food abundance and to respond to food shortage by mobilizing these fat stores. Embarking on the trail to understand lipid metabolism under stress, we have used adult male Caenorhabditis elegans as our model organism. C. elegans, as living organisms willing to survive, are also able to mount an adaptive response to food deprivation by depleting their intestinal fat stores. These fat stores possibly provide resources to launch the necessary adaptations to survive through the stress. Herein, we provide evidences that starvation stress improves viability coupled with an enhanced oxidative and thermal stress response and improved reproductive fitness. This delay in reproductive aging is regulated by arresting spermatogenesis during the starvation stress period and possibly mediated by GLP-1/Notch pathway. Furthermore, this short-term starvation stress-induced viability and vitality is mediated by DAF-16/FOXO transcription factor through the coordinated action of the insulin/IGF-1 receptor and the GLP-1/Notch pathway acting independently but in parallel. Facilitating strict molecular regulation during starvation period, it is imaginable that transcription and translation of new proteins are occurring. Previously, our laboratory had reported the increase in protein biosynthesis as well as ribosome biogenesis during the initial phase of starvation in C. elegans before the total depletion of their intestinal fat stores. We have further uncovered several ribosomal protein genes that are likely candidate for regulation.
Частини книг з теми "Specialized ribosome":
de Boer, Herman A., Dennis H. Eaton, and Anna S. Hui. "A Novel Approach for Mutational Analysis of the 16s rRNA Molecule Using the Specialized Ribosome System in Escherichia Coli." In Genetics of Translation, 343–51. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73139-6_27.
Ali, Shazia, Sumit Kumar, Asma Ali, and Syed Irtiza. "Structure and Function of Cells." In Examining Biological Foundations of Human Behavior, 30–46. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-2860-0.ch003.
Kyritsis, K. A., L. Angelis, Christos Ouzounis, and Ioannis Vizirianakis. "Understanding Specialized Ribosomal Protein Functions and Associated Ribosomopathies by Navigating Across Sequence, Literature, and Phenotype Information Resources." In Leveraging Biomedical and Healthcare Data, 35–51. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-809556-0.00003-4.