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Готові списки джерел за темами / Substance P Physiological effects / Статті в журналах

Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: Substance P Physiological effects.

Статті в журналах з теми "Substance P Physiological effects"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 31 липня 2025

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1

Drazen, J. M., S. A. Shore, and N. P. Gerard. "Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril." Journal of Applied Physiology 66, no. 3 (1989): 1364–72. http://dx.doi.org/10.1152/jappl.1989.66.3.1364.

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The effects of the neutral metalloendopeptidase inhibitor, thiorphan, and the angiotensin-converting enzyme inhibitor, captopril, on the changes in airway opening pressure (PaO), pulmonary arterial pressure (Ppa), and weight induced by intravascular administration of substance P were examined in isolated perfused and ventilated guinea pig lungs. Administration of 1 nmol substance P without enzyme inhibitors resulted in a significant (P less than 0.01) increase in the peak PaO during ventilation from 12.4 +/- 0.5 to 22.4 +/- 2.2 cmH2O; there were small statistically insignificant increases in P

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2

Oz, E., E. Aydemir, A. F. Korcum, and K. Fiskin. "The effects of substance P fragments on breast cancer cells." Journal of Clinical Oncology 29, no. 27_suppl (2011): 295. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.295.

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295 Background: Substance P (SP), a neuropeptide, is known to induce tumor cell proliferation. In contrast with intact peptide, the fragments of SP are suggested to inhibit the growth of various cancer cells. The aim of the present study was to determine cytotoxic effects of physiological fragments of SP either alone or in combination with radiotherapy on mouse breast cancer cells. Methods: In this study, we tested the physiological fragments of SP such as SP (4-11), SP (6-11) and SP (1-7). Dose-response and time-course studies were carried out with various concentrations (100-0.001 nM) of SP

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3

Worthen, G. S., R. S. Gumbay, D. T. Tanaka, and M. M. Grunstein. "Opposing hemodynamic effects of substance P on pulmonary vasculature in rabbits." Journal of Applied Physiology 59, no. 4 (1985): 1098–103. http://dx.doi.org/10.1152/jappl.1985.59.4.1098.

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Substance P is a peptide implicated in the control of a variety of physiological processes. Although substance P-containing neurons impinge on the pulmonary vasculature, the effects of substance P on the pulmonary circulation have not been systematically investigated. Rabbits were anesthetized with methohexital sodium and paralyzed with pancuronium bromide. Injection of substance P (0.002–0.10 microgram/kg) in the vena cava produced dose-dependent pulmonary vasoconstriction and systemic vasodilation. Pulmonary arterial pressure reached a peak within 15–20 s and declined toward base line over 1

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4

Bost, K. L., and D. W. Pascual. "Substance P: a late-acting B lymphocyte differentiation cofactor." American Journal of Physiology-Cell Physiology 262, no. 3 (1992): C537—C545. http://dx.doi.org/10.1152/ajpcell.1992.262.3.c537.

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The peptide substance P has been recognized for years as having dramatic effects on such diverse physiological responses as blood pressure regulation, peristalsis of the gut, and salivation. More recently, demonstration of substance P receptors on leukocytes and modulation of leukocyte functions by this peptide suggested that it might also have a role in immune regulation. This review focuses on the growing body of evidence that demonstrates substance P-induced effects on one population of leukocytes, namely B lymphocytes. Despite the diversity of experimental techniques used, there is surpris

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5

Fox, J. E., and E. E. Daniel. "Substance P: a potent inhibitor of the canine small intestine in vivo." American Journal of Physiology-Gastrointestinal and Liver Physiology 250, no. 1 (1986): G21—G27. http://dx.doi.org/10.1152/ajpgi.1986.250.1.g21.

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Intra-arterially administered substance P inhibited neurally activated contractions of the circular muscle of canine small intestine in vivo (lowest effective dose approximately 10(-13) mol). Excitation of intestine required higher (10(-10) mol) doses. The inhibitory effect required functioning nerves, since tetrodotoxin treatment eliminated it. However, inhibition of neurogenic contraction by substance P was unaffected by nicotinic or opiate receptor antagonists or by catecholamine depletion but was reduced by a selective substance P antagonist. Since the inhibition by substance P was also gr

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6

Makowska, Krystyna, Kamila Szymańska, Jarosław Całka, and Sławomir Gonkowski. "The Influence of Bisphenol A (BPA) on the Occurrence of Selected Active Substances in Neuregulin 1 (NRG1)-Positive Enteric Neurons in the Porcine Large Intestine." International Journal of Molecular Sciences 22, no. 19 (2021): 10308. http://dx.doi.org/10.3390/ijms221910308.

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Bisphenol A (BPA) is a substance used in the manufacture of plastics which shows multidirectional adverse effects on living organisms. Since the main path of intoxication with BPA is via the gastrointestinal (GI) tract, the stomach and intestine are especially vulnerable to the impact of this substance. One of the main factors participating in the regulation of intestinal functions is the enteric nervous system (ENS), which is characterized by high neurochemical diversity. Neuregulin 1 (NRG1) is one of the lesser-known active substances in the ENS. During the present study (performed using the

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7

Song, Jiawen, Lang Xin, Fukui Gao, Hao Liu, and Xingpeng Wang. "Effects of Foliar Selenium Application on Oxidative Damage and Photosynthetic Properties of Greenhouse Tomato under Drought Stress." Plants 13, no. 2 (2024): 302. http://dx.doi.org/10.3390/plants13020302.

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Both drought stress and exogenous selenium (Se) cause changes in plant physiological characteristics, which are key factors affecting crop yield. Although Se is known to be drought-resistant for crops, its internal physiological regulatory mechanisms are not clear. This study analyzed the effects of selenium application (SeA) on antioxidant enzyme activities, osmoregulatory substance contents, and photosynthetic characteristics of greenhouse tomatoes under drought stress and related physiological mechanisms. The results showed that drought stress induced oxidative damage in cells and significa

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8

Jing, Xiong, Chunju Cai, Shaohui Fan, Guanglu Liu, Changming Wu, and Benxue Chen. "Effects of Rhizome Integration on the Water Physiology of Phyllostachys edulis Clones Under Heterogeneous Water Stress." Plants 9, no. 3 (2020): 373. http://dx.doi.org/10.3390/plants9030373.

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Water is crucial to plant growth and development. Under heterogeneous environmental water deficiency, physiological integration of the rhizomatous clonal plant triggers a series of physiological cascades, which induces both signaling and physiological responses. It is known that the rhizome of Phyllostachys edulis, which connects associated clonal ramets, has important significance in this physiological integration. This significance is attributed to the sharing of water and nutrients in the vascular bundle of clonal ramets under heterogeneous water conditions. However, the physiological chara

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9

Wiese, Ashley J., Michael Rathbun, Mark T. Butt, et al. "Intrathecal Substance P-Saporin in the Dog." Anesthesiology 119, no. 5 (2013): 1163–77. http://dx.doi.org/10.1097/aln.0b013e3182a95164.

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Abstract Background: Neurokinin-1 receptors (NK1-rs) located on superficial dorsal horn neurons are essential for integration of nociceptive input. Intrathecal injection of substance P-saporin (SP-SAP) leads to local loss of spinal NK1-r (+) neurons suggesting its potential as a therapeutic agent for chronic pain. The authors determined, in a canine model, effects of lumbar intrathecal SP-SAP. Methods: Distribution of SP-SAP and Saporin was determined in plasma, lumbar cerebrospinal fluid, and tissue. Safety of intrathecal SP-SAP was determined in four groups (six dogs each) administered 0 (0.

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10

Holstein, B., and C. Cederberg. "Effects of tachykinins on gastric acid and pepsin secretion and on gastric outflow in the Atlantic cod, Gadus morhua." American Journal of Physiology-Gastrointestinal and Liver Physiology 250, no. 3 (1986): G309—G315. http://dx.doi.org/10.1152/ajpgi.1986.250.3.g309.

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Gastric acid and pepsin responses to substance P, physalaemin, eledoisin, and an eledoisin-related peptide, [Lys6]eledoisin-(6-11), were measured in gastrically and intestinally perfused cods. The intestinal perfusion maintains water balance and inhibits drinking. During basal conditions acid secretion was stimulated (approximately equal to 25%) by low doses (less than 0.13 nmol X kg-1 X h-1) of physalaemin and eledoisin. High doses (greater than 16 nmol X kg-1 X h-1) were inhibitory. Median and very high doses of substance P and eledoisin-related peptide, respectively, tended to stimulate aci

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11

Dakil, Ali Khalaf, and Aizhar H. Hasan. "Impact of Amphetamine and Captagon abuse on the liver and renal function." Romanian Journal of Medical Practice 19, no. 1 (2024): 5–11. http://dx.doi.org/10.37897/rjmp.2024.1.4.

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Background. Addiction is a multifaceted brain disorder characterized by compulsive substance use despite harmful consequences. The physiological effects of drugs, such as amphetamines and captagon, on organ functions remain a significant concern, with varying impacts based on substance type and duration of use. Aim of study. This study aimed to investigate the impact of amphetamine and captagon abuse on liver and kidney functions. By comparing physiological parameters between individuals with substance abuse history and a control group, the study sought to elucidate the health implications of

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12

Moss, I. R., and J. G. Inman. "Neurochemicals and respiratory control during development." Journal of Applied Physiology 67, no. 1 (1989): 1–13. http://dx.doi.org/10.1152/jappl.1989.67.1.1.

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During ontogeny, the central nervous system undergoes neuronal growth, regression, and remodeling. The development of neurotransmitter and modulator systems is a plastic process with individual temporal characteristics for each system. These characteristics include the synthesis, degradation, or uptake of neurochemicals and, largely independently, the appearance of their receptors. Message transmission during ontogeny is compounded by the variable development of these systems and by the coexistence and cofunction among these chemicals. Nine neurochemical systems are discussed: adenosine, gamma

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13

Seker, Engin. "Oxidative and physiological effects of carvedilol, a beta–blocker, in Daphnia magna." Revista Científica de la Facultad de Ciencias Veterinarias XXXIV, no. 3 (2024): 1–9. https://doi.org/10.52973/rcfcv-e34450.

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Carvedilol is a beta–blocker. Beta–blockers affect the heart and circulation. carvedilol is used to treat heart failure and hypertension. Although this substance has effects in humans and some animals, its effect on the physiological and antioxidant status of daphnids is unknown. The aim of this study was to determine the effect of carvedilol doses (0, 0.125, 0.45 and 0.90 mg·L-1) on physiological activities (heart rate, postabdominal paw activity and thoracic limb movements) and oxidative stress. In Daphnia magna; malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total glutat

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14

Hoover, Donald B. "Effects of capsaicin on release of substance P-like immunoreactivity and physiological parameters in isolated perfused guinea-pig heart." European Journal of Pharmacology 141, no. 3 (1987): 489–92. http://dx.doi.org/10.1016/0014-2999(87)90571-1.

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15

Thompson, Caitlin, and Martin L. Williams. "Review of the physiological effects of Phyllomedusa bicolor skin secretion peptides on humans receiving Kambô." Toxicology Research and Application 6 (January 2022): 239784732210857. http://dx.doi.org/10.1177/23978473221085746.

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Kambô is an Amazonian ritual which includes the application of the defensive secretion of the Phyllomedusa bicolor frog to superficial burns made on the skin of human participants. The secretion, which contains a range of biologically active linear peptides, induces a short purgative experience that is extensively reported by participants to leave them with positive physical, emotional and spiritual after-effects. Various peptides identified in the secretion exert analgesic, vascular, and gastric effects in vivo, and antimicrobial and anti-cancer effects, among others, in vitro. While there ha

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16

Holtcamp, Katie, Molly C. Nicodemus, Tommy Phillips, et al. "The Effects of a Collegiate Recovery Community Psychotherapy Program Incorporating Equine Interaction during the COVID-19 Pandemic on Young Adults with Substance Abuse Disorder." COVID 4, no. 2 (2024): 151–69. http://dx.doi.org/10.3390/covid4020013.

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While psychotherapy incorporating equine interaction (PIE) has proven to be a viable therapeutic intervention, it is not a common mental health service found on college campuses. Nevertheless, with the rise of mental health challenges on campuses after the COVID-19 pandemic, a need for effective therapeutic solutions is warranted. Therefore, the objective of this study was to determine the effect of a collegiate recovery community (CRC) PIE program for substance abuse disorder (SUD) compared to that of traditional cognitive behavioral therapy (CBT) and to determine whether physiological synchr

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17

Ichikawa, S., S. P. Sreedharan, R. L. Owen, and E. J. Goetzl. "Immunochemical localization of type I VIP receptor and NK-1-type substance P receptor in rat lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 268, no. 4 (1995): L584—L588. http://dx.doi.org/10.1152/ajplung.1995.268.4.l584.

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Peptidergic nerves in the respiratory tract release vasoactive intestinal peptide (VIP) and substance P (SP), which mediate physiological and immune functions. Antipeptide antibodies to type I VIP receptor (VIPR) and NK-1-type SP receptor (SPR) were used to identify these receptors in normal rat lungs. VIPRs and SPRs were detected on airway epithelium from the trachea to the respiratory bronchioles but not in alveoli, submucosal glands, or pulmonary smooth muscle, except for that of some pulmonary veins. VIPRs also were expressed on macrophages around capillaries, in tracheal and bronchial con

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18

Ding, Ting, and Yong Li. "Quorum sensing inhibitory effects of vanillin on the biofilm formation of Pseudomonas fluorescens P07 by transcriptome analysis." SDRP Journal of Food Science & Technology 5, no. 7 (2021): 275–92. http://dx.doi.org/10.25177/jfst.5.7.ra.10686.

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Pseudomonas fluorescens is an important psychrotrophic food-spoilage bacterium. Quorum sensing (QS) enables bacteria to control various physiological processes. Hence, targeting bacterial QS would be a novel method to improve food quality. In this study, P. fluorescens P07 was treated with vanillin, which showed strong QS inhibitory activity, and its resultant effects on swarming motility, biofilm formation, and extracellular polymeric substance (EPS) secretion were measured. The mechanisms underlying the inhibitory effects were then explored by transcriptomic analysis. The results showed that

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19

Thiengo, Cássio Carlette, Danilo Messias de Oliveira, João Victor Silva Bernardes, et al. "Bio-inputs promoting marandu grass growth: productivity, physiological response and nitrogen accumulation." May 2023, no. 17(05):2023 (May 1, 2023): 423–30. http://dx.doi.org/10.21475/ajcs.23.17.05.p3811.

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Nutrient replenishment is one of the significant factors limiting the full development of extensive pasturelands. As a result, bio-inputs have been increasingly used under field conditions to improve plant growth in low-fertility soils. This study aimed to evaluate their effects on the productivity, physiological responses to and nitrogen (N) accumulation in marandu grass (Urochloa brizantha cv. marandu). The experiment was carried out using a randomized block design with four treatments and three replicates in a greenhouse under controlled conditions. In low-fertility soils, lower synthetic f

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20

Panettieri, R. A., R. K. Murray, L. R. DePalo, P. A. Yadvish, and M. I. Kotlikoff. "A human airway smooth muscle cell line that retains physiological responsiveness." American Journal of Physiology-Cell Physiology 256, no. 2 (1989): C329—C335. http://dx.doi.org/10.1152/ajpcell.1989.256.2.c329.

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We report the development of a nontransformed line of human airway smooth muscle cells retaining smooth muscle-specific contractile protein expression and physiological responsiveness to agonists implicated in inflammatory airway diseases. Specific responses to histamine, leukotrienes, bradykinin, platelet-activating factor, substance P, and thromboxane analogues are demonstrated as well as functional coupling to beta-adrenergic receptors. The cell line was characterized using indirect immunofluorescence, as well as electrophoretic separation and immunoblot analysis of smooth muscle-specific a

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21

Zhao, Jiantao, Rongzheng Huang, Kaixin Yang, Chunhui Ma, and Qianbing Zhang. "Effects of Nitrogen and Phosphorus Fertilization on Photosynthetic Properties of Leaves and Agronomic Characters of Alfalfa over Three Consecutive Years." Agriculture 12, no. 8 (2022): 1187. http://dx.doi.org/10.3390/agriculture12081187.

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The present study aimed to investigate the nitrogen (N) and phosphorus (P) fertilization of continuous addition effects plant biomass, the physiological properties of leaves and the antioxi-dant enzyme activities of alfalfa (Medicago sativa L) in the northern Xinjiang region; including the no fertilization (CK), nitrogen fertilization (N, 120 kg·ha−1), phosphorus fertilization (with low amount of N) (P, 100 kg·ha−1 P and 23.5 kg·ha−1 N) and combined nitrogen and phosphorus fertilization (NP, 120 kg·ha−1 N and 100 kg·ha−1 P) on the K well supplied soil. After three consecutive years of the supp

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22

Rameshwar, P., D. Ganea, and P. Gascon. "In vitro stimulatory effect of substance P on hematopoiesis." Blood 81, no. 2 (1993): 391–98. http://dx.doi.org/10.1182/blood.v81.2.391.391.

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Abstract The neuropeptide Substance P (SP) is widely distributed in the peripheral nervous system. Its biologic effects have been extensively studied in the immune system. However, even though the bone marrow (BM) is innervated with SP-immunoreactive fibers and some of its cells not only express SP receptors (T and B cells, endothelial cells, and macrophages) but also produce SP (macrophages, eosinophils, and endothelial cells), the effects of SP on hematopoiesis are scanty. Furthermore, SP induces the production of hematopoietic growth factors (HGFs) (interleukin-1 [IL-1], IL-6, and tumor nec

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23

Rameshwar, P., D. Ganea, and P. Gascon. "In vitro stimulatory effect of substance P on hematopoiesis." Blood 81, no. 2 (1993): 391–98. http://dx.doi.org/10.1182/blood.v81.2.391.bloodjournal812391.

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The neuropeptide Substance P (SP) is widely distributed in the peripheral nervous system. Its biologic effects have been extensively studied in the immune system. However, even though the bone marrow (BM) is innervated with SP-immunoreactive fibers and some of its cells not only express SP receptors (T and B cells, endothelial cells, and macrophages) but also produce SP (macrophages, eosinophils, and endothelial cells), the effects of SP on hematopoiesis are scanty. Furthermore, SP induces the production of hematopoietic growth factors (HGFs) (interleukin-1 [IL-1], IL-6, and tumor necrosis fac

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24

Huston, Joseph P., and Mary-S. Oitzl. "The relationship between reinforcement and memory: Parallels in the rewarding and mnemonic effects of the neuropeptide substance P." Neuroscience & Biobehavioral Reviews 13, no. 2-3 (1989): 171–80. http://dx.doi.org/10.1016/s0149-7634(89)80027-2.

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25

Duverger, D., L. Edvinsson, E. T. MacKenzie, et al. "Concentrations of Putative Neurovascular Transmitters in Major Cerebral Arteries and Small Pial Vessels of Various Species." Journal of Cerebral Blood Flow & Metabolism 7, no. 4 (1987): 497–501. http://dx.doi.org/10.1038/jcbfm.1987.93.

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The levels of noradrenaline, neuropeptide Y, 5-hydroxytryptamine, and substance P were measured and compared between the large arteries of the circle of Willis and the small cerebral vessels of the pia mater in the rat, rabbit, cat, and monkey. In all species, noradrenaline and neuropeptide Y concentrations were greater in the larger arteries than in small pial vessels. Noradrenaline concentrations were reduced following cervical sympathectomy, with the extent of diminution differing greatly in the various the effects of cervical ganglionectomy on neuropeptide Y concentrations were less pronou

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26

Okoli, Chizimuzo, Jonathan Kodet, and Heather Robertson. "Behavioral and Physiological Responses to Nicotine Patch Administration Among Nonsmokers Based on Acute and Chronic Secondhand Tobacco Smoke Exposure." Biological Research For Nursing 18, no. 1 (2015): 60–67. http://dx.doi.org/10.1177/1099800415579261.

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Introduction: Despite the large amount that is known about the physical health effects of secondhand tobacco smoke (SHS) exposure, little is known about the behavioral health effects. Nicotine, the principle psychoactive substance in SHS, elicits subjective mood and physiological responses in nonsmokers. However, no studies have examined the subjective mood or physiological responses to nicotine in nonsmokers while accounting for prior chronic or acute SHS exposure. Methods: A 7-mg nicotine patch was administered to 17 adult nonsmokers for 2 hr. Main outcome measures obtained at ½ hr, 1 hr, an

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27

Cantó, Antolin, Teresa Olivar, Francisco Javier Romero, and María Miranda. "Nitrosative Stress in Retinal Pathologies: Review." Antioxidants 8, no. 11 (2019): 543. http://dx.doi.org/10.3390/antiox8110543.

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Nitric oxide (NO) is a gas molecule with diverse physiological and cellular functions. In the eye, NO is used to maintain normal visual function as it is involved in photoreceptor light transduction. In addition, NO acts as a rapid vascular endothelial relaxant, is involved in the control of retinal blood flow under basal conditions and mediates the vasodilator responses of different substances such as acetylcholine, bradykinin, histamine, substance P or insulin. However, the retina is rich in polyunsaturated lipid membranes and is sensitive to the action of reactive oxygen and nitrogen specie

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28

Yoo, Seon Pil, Myunggi Baik, Hyeok Joong Kang, et al. "312 Effects of castration stress on behaviors and leukocyte cytokine gene expression in Korean cattle bull calves." Journal of Animal Science 97, Supplement_3 (2019): 8–9. http://dx.doi.org/10.1093/jas/skz258.015.

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Abstract This study investigated behavioral, physiological, and inflammatory responses, as well as leukocyte cytokine gene expression, of Korean cattle calves following surgical castration. Nineteen Korean cattle bull calves (average body weight, 254.5 kg; average age, 8.2 months) were assigned to one of two treatment groups: control (n = 9) and surgical castration (n = 10). Castration was performed surgically using Newberry knives and a Henderson castrating tool. Blood was collected immediately before castration and at 0.5 h, 6 h, 1 d, 3 d, 7 d, and 14 d after castration, and analyzed cortiso

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29

Bouras, C., P. Schulz, J. Constantinidis, and R. Tissot. "Differential Effects of Acute and Chronic Administration of Haloperidol on Substance P and Enkephalins in Diverse Rat Brain Areas." Neuropsychobiology 16, no. 4 (1986): 169–74. http://dx.doi.org/10.1159/000118321.

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30

Colombo, Eduardo, Reinaldo F. Cooke, Alice Brandão, et al. "268 Administering an appeasing substance to optimize welfare and performance of receiving cattle." Journal of Animal Science 98, Supplement_4 (2020): 193. http://dx.doi.org/10.1093/jas/skaa278.355.

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Abstract This experiment evaluated the impacts of bovine appeasing substance (BAS) administration on performance, health, and physiological responses of feedlot cattle during a 45-d receiving period. A total of 342 recently-weaned Angus-influenced steers, originating from 16 cow-calf operations, were obtained from an auction yard on d -1 and road-transported (12 h) to the feedlot. Upon arrival on d 0, body weight (BW) was recorded and steers were ranked by BW and source and assigned to receive BAS (Nutricorp, Araras, SP, Brazil; n = 171) or placebo (diethylene glycol monoethyl ether; CON; n =

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Zhou, Kangqi, Zhong Chen, Junqi Qin, et al. "Effects of Salinity on Muscle Nutrition, Fatty Acid Composition, and Substance Anabolic Metabolism of Blue Tilapia Oreochromis aureus." Journal of Applied Ichthyology 2024 (January 8, 2024): 1–14. http://dx.doi.org/10.1155/2024/5549406.

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A 60-day culture in brackish water (0, 3, 5, 7, 9, and 11 ppt) was conducted to study the effects of salinity on muscle nutrition, fatty acid composition, and anabolic metabolism of blue tilapia Oreochromis aureus. Current research showed that WGR, SGR, and FCR indicators of tilapia were better improved in brackish water. In addition, the physical properties of O. aureus muscle demonstrated a positive correlation with salinity levels. The content of amino acids and fatty acids in O. aureus muscles grown under salinity was higher than that in freshwater (P>0.05). Venn analysis showed that 23

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Periferakis, Aristodemos-Theodoros, Argyrios Periferakis, Konstantinos Periferakis, et al. "Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives." Nutrients 15, no. 19 (2023): 4097. http://dx.doi.org/10.3390/nu15194097.

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Capsaicin is a phytochemical derived from plants of the genus Capsicum and subject of intensive phytochemical research due to its numerous physiological and therapeutical effects, including its important antimicrobial properties. Depending on the concentration and the strain of the bacterium, capsaicin can exert either bacteriostatic or even bactericidal effects against a wide range of both Gram-positive and Gram-negative bacteria, while in certain cases it can reduce their pathogenicity by a variety of mechanisms such as mitigating the release of toxins or inhibiting biofilm formation. Likewi

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Kuprash, Liana, Tetyana Panteleymonova, Ludmila Sharabura, et al. "Pharmacology-based toxicity assessment of molsidomine and ATP-LONG combination with singular and repetitive injections under experimental conditions." Ageing & Longevity 2, no. 3 2021 (2021): 1–13. http://dx.doi.org/10.47855/jal9020-2021-3-1.

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Abstract. The aim of the work was to study toxic properties of the new combined drug which comprise nitrovasodilator molsidomine and adenosine- 5’-triphosphate in a form of coordination compound with histidine, magnesium, and potassium (ATP-LONG). The drug was examined for its acute and subacute toxicity on Balb/c mice and Wistar rats of reproductive age with peroral (p/o) and sublingual (s/l) administrations. It has been established that LD50 of the substance contains over 10000 mg/kg (p/o) and 5010 mg/kg (s/l), which corresponds to the category of Practically non-toxic substances. The repeti

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34

Schmid, H. A., L. Jansky, and F. K. Pierau. "Temperature sensitivity of neurons in slices of the rat PO/AH area: effect of bombesin and substance P." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 2 (1993): R449—R455. http://dx.doi.org/10.1152/ajpregu.1993.264.2.r449.

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The effects of bombesin (Bom) and substance P (SP) were investigated in 156 temperature-sensitive and -insensitive neurons in slices of the preoptic and anterior hypothalamic area (PO/AH) of rats. Application of Bom increased the firing rate (FR) in 68% (n = 38) of the warm-sensitive and in 62% (n = 39) of the temperature-insensitive neurons. One cold-sensitive neuron was excited; a second was not affected by the peptide. No neuron decreased its activity after Bom application. SP excited 80% (n = 15) of the warm-sensitive neurons and 48% (n = 29) of the temperature-insensitive neurons. Two col

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Wang, Tobias, Michael Axelsson, Jorgen Jensen, and J. Michael Conlon. "Cardiovascular actions of python bradykinin and substance P in the anesthetized python, Python regius." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 279, no. 2 (2000): R531—R538. http://dx.doi.org/10.1152/ajpregu.2000.279.2.r531.

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The cardiovascular actions of python bradykinin (BK) and substance P (SP) have been investigated in the anesthetized ball python, Python regius. Bolus intra-arterial injections of python BK (0.03–3 nmol/kg) produced concentration-dependent increases in arterial blood pressure, heart rate (HR), and cardiac output concomitant with small decreases in systemic resistance and stroke volume. Intra-arterial injection of 3 nmol/kg python BK produced a tenfold increase in circulating concentration of norepinephrine, but epinephrine levels did not change. BK-induced tachycardia was attenuated (>90%)

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Frase, Sibylle, Franziska Löffler, and Jonas A. Hosp. "Enhancing Post-Stroke Rehabilitation and Preventing Exo-Focal Dopaminergic Degeneration in Rats—A Role for Substance P." International Journal of Molecular Sciences 23, no. 7 (2022): 3848. http://dx.doi.org/10.3390/ijms23073848.

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Dopaminergic signaling is a prerequisite for motor learning. Delayed degeneration of dopaminergic neurons after stroke is linked to motor learning deficits impairing motor rehabilitation. This study investigates safety and efficacy of substance P (SP) treatment on post-stroke rehabilitation, as this neuropeptide combines neuroprotective and plasticity-promoting properties. Male Sprague Dawley rats received a photothrombotic stroke within the primary motor cortex (M1) after which a previously acquired skilled reaching task was rehabilitated. Rats were treated with intraperitoneal saline (contro

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LANGENFELD, M. R., S. NAKHLA, A. K. DEATH, W. JESSUP, and D. S. CELERMAJER. "Endothelin-1 plus oxidized low-density lipoprotein, but neither alone, increase human monocyte adhesion to endothelial cells." Clinical Science 101, no. 6 (2001): 731–38. http://dx.doi.org/10.1042/cs1010731.

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Endothelin-1 is a potent vasoconstrictor and mitogenic peptide that is implicated in the atherosclerosis of apolipoprotein E-deficient mice and may promote atherogenesis in humans. We hypothesized that endothelin-1 might promote the adhesion of monocytes to endothelial cells, a key early event in atherosclerosis. We investigated the adhesion of primary human monocytes (isolated by elutriation) to human umbilical vein endothelial cell cultures after incubation with endothelin-1 (0.1 and 0.01nM; approximately physiological concentrations), copper-oxidized low-density lipoprotein (LDL) (0.1mg/ml)

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Esteban, Francisco, Pablo Ramos-García, Miguel Muñoz, and Miguel Ángel González-Moles. "Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature." International Journal of Environmental Research and Public Health 19, no. 1 (2021): 375. http://dx.doi.org/10.3390/ijerph19010375.

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Head and neck cancer is a growing worldwide public health problem, accounting for approximately 1,500,000 new cases and 500,000 deaths annually. Substance P (SP) is a peptide of the tachykinin family, which has roles related to a large number of physiological mechanisms in humans. The implications of SP in carcinogenesis have recently been reported through the stimulation of the neurokinin 1 receptor (NK1R), or directly, through the effects derived from the constitutive activation of NK1R. Consequently, SP/NK1R seems to play relevant roles in cancer, upregulating cell proliferation, cell migra

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Osório, F. L., A. E. M. Barbar, M. F. Donadon, and J. A. S. Crippa. "A Single Dose of Oxytocin on Music Performance Anxiety: Results Involving a Situation of Simulated Performance." European Psychiatry 41, S1 (2017): S110. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1882.

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IntroductionMusic performance anxiety (MPA) is a persistent and distressing experience that involves apprehension linked with musical performance in public (individual or collective). Anxious individuals concentrate their anxiety in situations that involve social scrutiny, favoring distorted, dysfunctional, and negative interpretations of that situation followed by experiences of physiological symptoms associated with the exposure. The most commonly used substances in the pharmacological management of MPA are beta-blockers and benzodiazepines. However, these options are not fully efficient and

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Dolgikh, O. V., D. G. Dianova, A. S. Shirinkina, and T. V. Bombela. "Immunomodulatory properties of plant polyphenols shown in an <i>in vitro</i> experimental model." Medical Immunology (Russia) 26, no. 1 (2023): 143–50. http://dx.doi.org/10.15789/1563-0625-ipo-2655.

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Polyphenols exert a wide range of biological effects, including immunomodulatory action. Studying the effects of flavonoids on phagocytic activity of specialized phagocytic cells seems to be a rather promising direction for their further usage as pharmacological (therapeutic) agents. Quercetin and luteolin are the most commonly studied flavonoid substances with pleiotropic action. In-depth study and understanding of immunotropic mechanisms (e.g., regulation of phagocytosis) is a prerequisite for adequate pharmacotherapy in infectious conditions, nonspecific inflammatory diseases, autoimmune an

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Joad, J. P., K. S. Kott, and A. C. Bonham. "Exposing guinea pigs to ozone for 1 wk enhances responsiveness of rapidly adapting receptors." Journal of Applied Physiology 84, no. 4 (1998): 1190–97. http://dx.doi.org/10.1152/jappl.1998.84.4.1190.

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Acute exposure to ozone causes changes in breathing pattern and lung function which may be caused in part by stimulation of rapidly adapting receptors (RARs). The consequences of repeated daily ozone exposure on RAR responsiveness are unknown, although ozone-induced changes in pulmonary function diminish with repeated exposure. Accordingly, we investigated whether repeated daily ozone exposure diminishes the general responsiveness of RARs. Guinea pigs ( n = 30) were exposed to 0.5 parts/million ozone or filtered air (8 h/day for 7 days). The animals were then anesthetized, and RAR impulse acti

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Wan, Xiang, Guoxiang Wang, Fei Yang, and Yueming Zhu. "Responses of a Submerged Macrophyte Potamogeton crispus and Epiphytic Biofilm to Humic-Substance Enrichment Coupled with Brownification in Freshwater Habitats." Water 15, no. 16 (2023): 2860. http://dx.doi.org/10.3390/w15162860.

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Brownification denotes increasing water color, partly caused by increasing dissolved organic matter of terrestrial origin in freshwater. Brownification has become a wide-spread environmental problem because water color alters the physicochemical environment and biological communities in aquatic ecosystems. However, our understanding of its ecological effects on aquatic macrophytes is limited. Here, an indoor mesocosm experiment with a common submerged macrophyte, Potamogeton crispus, along an increasing gradient of brownification was conducted over a period of 42 days. Results showed that P. c

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de Pedro-Carracedo, J., J. Clemente, D. Fuentes-Jimenez, M. F. Cabrera-Umpiérrez, and A. P. Gonzalez-Marcos. "Photoplethysmographic Signal-Diffusive Dynamics as a Mental-Stress Physiological Indicator Using Convolutional Neural Networks." Applied Sciences 13, no. 15 (2023): 8902. http://dx.doi.org/10.3390/app13158902.

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Stress is one of the primary triggers of serious pathologies (e.g., depression, obesity, heart attack). Prolonged exposure to it can lead to addictive substance consumption and even suicide, without ignoring other adverse side effects in the economic, work and family spheres. Early detection of stress would relax the pressure of medical practice exercised by the population affected and result in a healthier society with a more satisfying quality of life. In this work, a convolutional-neural-network (CNN) model is proposed to detect an individual’s stress state by analyzing the diffusive dynami

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Johnston, Elle P., Elizabeth B. Kegley, Jeremy G. Powell, et al. "PSIV-4 Effectiveness of maternal bovine appeasing substance on growth, physiological, and behavioral responses of high-risk stocker cattle." Journal of Animal Science 102, Supplement_3 (2024): 548–49. http://dx.doi.org/10.1093/jas/skae234.616.

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Abstract Stocker cattle purchased at auction can be susceptible to disease due to the stressors associated with the auction process. These cattle are labeled “high-risk” due to their decreased immune system during transportation, handling, and vaccination processes. The objective of this study was to determine the efficacy of a maternal bovine appeasing substance, FerAppease, on growth performance and fearfulness of stocker cattle. Male beef calves (n = 80) were purchased at auction and transported to the University of Arkansas Division of Agriculture Savoy Research Complex Beef Stocker Unit.

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Mori, Takahide, Minoru Irahara, Haruhiko Saito, Yoshio Ohno, and Eiji Hosoi. "Inhibitory action of somatostatin on meiotic maturation of cultured porcine follicular ova." Acta Endocrinologica 110, no. 3 (1985): 408–12. http://dx.doi.org/10.1530/acta.0.1100408.

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Abstract. To investigate the physiological importance of somatotrophin release-inhibiting factor (SRIF), effects in vitro of synthetic SRIF 14 on germinal vesicle breakdown (GVB) of cultured porcine follicular ova were studied. The proportion of ova with GVB decreased gradually and significantly with increasing concentrations of SRIF 14 in the range from 6 × 10−12 to 6 × 10−7 m during a 22 h period of culture. The inhibitory effect was apparent for the period between 14 and 22 h in the course of culture but was reversed by a concomitant addition of anti-SRIF to the medium. Neither synthetic ox

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Kanazawa, H., H. Kamoi, T. Kawaguchi, et al. "PAMP is a novel inhibitor of the tachykinin release in the airway of guinea pigs." American Journal of Physiology-Lung Cellular and Molecular Physiology 272, no. 6 (1997): L1066—L1069. http://dx.doi.org/10.1152/ajplung.1997.272.6.l1066.

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Proadrenomedullin NH2-terminal 20 peptide (PAMP), a newly identified hypotensive peptide, may play physiological roles in airway and cardiovascular controls. This study was designed to determine the mechanism responsible for the bronchoprotective effects of PAMP on capsaicin-induced bron-choconstriction in anesthetized guinea pigs. PAMP (10(-8)-10(-6) M) significantly inhibited capsaicin-induced bronchoconstriction in a dose-dependent manner. The bronchoprotective effect of PAMP (10(-6) M) was as large as that of isoproterenol (10(-7) M) and lasted > 10 min. The concentration of immunoreact

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Joborn, Henrik, Rolf Larsson, Jonas Rastad, Peter Nygren, Göran Åkerström, and Sverker Ljunghall. "Vasoactive intestinal polypeptide stimulates parathyroid hormone release by interaction with cyclic adenosine monophosphate production of bovine parathyroid cells." Acta Endocrinologica 124, no. 1 (1991): 54–59. http://dx.doi.org/10.1530/acta.0.1240054.

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Abstract. Influence of vasoactive intestinal polypeptide, neuropeptide Y, calcitonin gene-related peptide, and substance P was investigated on dispersed parathyroid cells of adult cattle. At a physiological concentration of extracellular calcium, vasoactive intestinal polypeptide stimulated the parathyroid hormone release in a dose-dependent manner, whereas no effects were noted for the other peptides. The dependency of PTH secretion upon extracellular calcium was shifted to the right by vasoactive intestinal polypeptide at 10−6 mol/l, with a tendency for greater effects at low (0.5 mmol/l) th

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Shiba, Fumie, Shiiko Maekawara, Atsuko Inoue, Koji Ohta, and Mutsumi Miyauchi. "Antinociceptive effect of Equisetum arvense extract on the stomatitis hamster model." PLOS ONE 19, no. 11 (2024): e0313747. http://dx.doi.org/10.1371/journal.pone.0313747.

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Recurrent aphthous stomatitis leads to ulcers that cause severe pain, which is a substantial burden on patients. Equisetum arvense extract (EA) is a crude drug that promotes wound healing of mucous membranes caused by perineal incision during childbirth and alleviates pain. Here, we elucidated the effects of EA on wound healing and pain in a stomatitis hamster model. After stomatitis induction, two different EA doses were continuously applied to the wound area through the intramucosal injection of acetic acid into the cheek pouch (stomatitis/100*EA group and stomatitis/EA group). The body weig

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Jung, Seung Hee, Yun Ha Lee, Eun Kyu Lee, et al. "Effects of Plant-Based Extract Mixture on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized, Double-Blind, Paralleled, Placebo-Controlled Clinical Trial." Journal of Clinical Medicine 12, no. 16 (2023): 5244. http://dx.doi.org/10.3390/jcm12165244.

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Hangovers are uncomfortable physiological symptoms after alcohol consumption caused by acetaldehyde, a toxic substance in which alcohol is metabolized by alcohol dehydrogenase (ADH). Rapid alcohol and acetaldehyde decomposition are essential to alleviate alcohol handling symptoms. This study investigated the effects of HY_IPA combined with Mesembryanthemum crystallinum, Pueraria lobata flower, and Artemisia indica on alleviating hangovers. A randomized, double-blind, parallel-group, placebo-controlled clinical study was conducted on 80 individuals with hangover symptoms. Alcohol intake was 0.9

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Marques, Rodrigo S., Keenan Kvamme, Vinicius Cruz, Eduardo Colombo, and Reinaldo Cooke. "2 Effects of Multiple Bovine Appeasing Substance Administration During a 42-Day Preconditioning Program on Physiologic, Health, and Performance Responses of Feeder Cattle." Journal of Animal Science 100, Supplement_4 (2022): 14–16. http://dx.doi.org/10.1093/jas/skac313.020.

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Abstract This experiment evaluated the effects of multiple bovine appeasing substance administration during a 42-day preconditioning program followed by feedlot receiving period on productivity, health, and physiological variables of feeder cattle. Ninety recently weaned calves were obtained from Red Bluff Ranch (Norris, MT). All calves were weaned and weighed (prior to transport). Calves were loaded into a livestock trailer, transported for 70 km, and unloaded at the Bozeman Agricultural Research and Teaching Farm for a 42-day preconditioning program. Upon arrival, calf body weight was record

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