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Дисертації з теми "Target penetration"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Zhou, Yu. "Simulation of High-velocity Penetration for Rigid Projectile into Plain Concrete Target using Discrete Element Method." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/31325.

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Penetration of high velocity is of concern for both civilian and military research for decades, and computerized simulation is the scholarâ s focus in recent years. This study presents a study on the Discrete Element Method (DEM) simulation of plain concrete targetâ s behavior under high-velocity penetration of rigid projectile. In this thesis, different types of research works including empirical, analytical and numerical methods in penetration by the previous scholars were carefully reviewed. A DEM-based concrete model was established by using software PFC3D. The major micro-variables o

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2

Renström, René. "Impact of Metallic Projectiles on a Ceramic Target Surface : Transition Between Interface Defeat and Penetration." Doctoral thesis, Uppsala universitet, Hållfasthetslära, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7264.

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The purpose of this thesis is to gain understanding of the load on flat target surfaces produced by projectile impact. Models are proposed from which upper and lower bounds can be derived for the transition be-tween interface defeat and normal penetration. It is shown that the dominating contribution to the normal load is generally provided by the hydrodynamic pressure due to the effect of inertia. In addition it is shown that the contributions from yield strength and compressibility are also significant. For a cylindrical tungsten alloy projectile at an impact velocity representative of to-da

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3

Lubda, Markus [Verfasser], Harald [Akademischer Betreuer] Kolmar, and Hagen Jörg [Akademischer Betreuer] von. "Target-Site Penetration of Active Ingredients in Human Skin / Markus Lubda ; Harald Kolmar, Jörg von Hagen." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://d-nb.info/1220832898/34.

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4

Lundberg, Patrik. "Interface Defeat and Penetration: Two Modes of Interaction between Metallic Projectiles and Ceramic Targets." Doctoral thesis, Uppsala University, Department of Engineering Sciences, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4641.

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<p>Ceramics constitute an important group of low-density armour materials. Their high intrinsic strength makes it possible to design ceramic armour systems capable of defeating projectiles directly on the ceramic surface. This capability, named interface defeat, signifies that the projectile material is forced to flow radially outwards on the surface of the ceramic without penetrating significantly.</p><p>This thesis presents impact experiments between long-rod projectiles and ceramic targets. The projectile/target interaction was studied using flash X-ray technique. Transition velocities (the

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5

Mullen, Damon Anthony. "COMPARISON OF MAXIMUM FORCES REQUIRED TO PENETRATE TEN AND TWENTY PERCENT BALLISTICS GELATIN, MEAT, AND CLAY TO ASSESS VARIATION BETWEEN TARGET MEDIAIN ARROW PENETRATION STUDIES." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1619013100008557.

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6

Ballew, Wesley D. "Taylor Impact Test and Penetration of Reinforced Concrete Targets by Cylindrical Composite Rods." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/34098.

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We use the three-dimensional finite element code DYNA3D to analyze two problems: (a) the normal impact of a cylindrical monolithic or composite rod against a smooth flat rigid target, (commonly known as the Taylor impact test), and (b) the penetration of composite and monolithic steel cylindrical rods into reinforced concrete targets. The composite rod is made of either a steel or copper shell enclosing a ceramic. The ceramic and the steel are assumed to fail at a critical value of the effective plastic strain, whereas no failure is considered in the copper. The thermoviscoplastic response

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7

Machado, Brenda I. "Characterization and cytotoxic assessment of ballistic aerosolized particulates for tungsten alloy penetrators interfacing with steel targets." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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8

Parker, Lonnie T. "Enhancement of a three dimensional target model for deep ground penetrating radar systems /." Online version of thesis, 2006. https://ritdml.rit.edu/dspace/handle/1850/2890.

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9

Woolmore, Nicola J. "The failure of a tungsten carbide-cobalt cored projectile penetrating a hard target." Thesis, Cranfield University, 2010. http://dspace.lib.cranfield.ac.uk/handle/1826/4657.

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Experimental results are presented from an investigation of the parameters of a ceramic-faced armour system that are required to induce damage in a tungsten carbide - cobalt (WC-Co) penetrator. A WC-Co material model has been successfully developed and implemented within the numerical hydrocode AUTODYN 2D. The understanding of penetration mechanisms was used to guide a parametric investigation, validating the WC-Co material failure model with experimental results. A series of experiments has been conducted firing the Russian 14.5 mm BS41 WC-Co cored projectile into various thicknesses and type

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10

Woolmore, N. J. "The failure of a tungsten carbide-cobalt cored projectile penetrating a hard target." Thesis, Engineering Systems Department, 2010. http://dspace.lib.cranfield.ac.uk/handle/1826/4657.

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Анотація:

Experimental results are presented from an investigation of the parameters of a ceramic-faced armour system that are required to induce damage in a tungsten carbide - cobalt (WC-Co) penetrator. A WC-Co material model has been successfully developed and implemented within the numerical hydrocode AUTODYN 2D. The understanding of penetration mechanisms was used to guide a parametric investigation, validating the WC-Co material failure model with experimental results. A series of experiments has been conducted firing the Russian 14.5 mm BS41 WC-Co cored projectile into various thicknesses and t

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11

Hislop, Gregory Francis. "Diffraction Tomographic Imaging of Shallowly Buried Targets using Ground Penetrating Radar." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16125/1/Gregory_Hislop_Thesis.pdf.

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The problem of subsurface imaging with Ground Penetrating Radar (GPR) is a challenging one. Due to the low-pass nature of soil sensors must utilise wave-lengths that are of the same order of magnitude as the object being imaged. This makes imaging difficult as straight ray approximations commonly used in higher frequency applications cannot be used. The problem becomes even more challenging when the target is shallowly buried as in this case the ground surface reflection and the near-field parameters of the radar need to be considered. This thesis has investigated the problem of imaging sh

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12

Hislop, Gregory Francis. "Diffraction Tomographic Imaging of Shallowly Buried Targets using Ground Penetrating Radar." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16125/.

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The problem of subsurface imaging with Ground Penetrating Radar (GPR) is a challenging one. Due to the low-pass nature of soil sensors must utilise wave-lengths that are of the same order of magnitude as the object being imaged. This makes imaging difficult as straight ray approximations commonly used in higher frequency applications cannot be used. The problem becomes even more challenging when the target is shallowly buried as in this case the ground surface reflection and the near-field parameters of the radar need to be considered. This thesis has investigated the problem of imaging sh

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13

Branscome, Ewell Caleb. "A Multidisciplinary Approach to the Identification and Evaluation of Novel Concepts for Deeply Buried Hardened Target Defeat." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14092.

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The objective of the work described was to identify and explore a paradigm shifting solution that could offer leap-ahead capabilities to counter current and future DBHT threats while mitigating or eliminating the self-deterrence issue. A multidisciplinary approach to the problem was formulated and implemented. Systematic evaluation of DHBT defeat alternatives lead to the selection of a thermal subterrene as a hypothetical means of providing such a capability. A number of possible implementation alternatives for a thermal subterrene were investigated, resulting in the identification of the Radi

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14

Nilavalan, Rajagopal. "FDTD modelling, measurements and analyses of post reception synthetic focusing techniques in ground penetrating radars." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/84cded96-2d07-4f7d-887d-1fc4854b75e3.

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15

Almutiry, Muhannad Salem S. "Extraction of Weak Target Features from Radar Tomographic Imagery." University of Dayton / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1470154676.

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16

Chu, Hin Lun. "Intracellular delivery of radioimmunoconjugates that target the cancer testis antigen, NY-ESO-1." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:84c830c4-c216-4b2c-8383-e1119d77c295.

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Cancer testis antigens (CTA) represent attractive targets for targeted radiotherapy and imaging as their expression is restricted to cancer and germ cells. NY-ESO-1, a member of the CTA family, is highly immunogenic and expressed in multiple tumor types including carcinoma of bladder, liver lung. The aim of this study was to develop radioimmunoconjugates (RIC) to target NY-ESO-1 protein in cancer cells. Anti-NY-ESO-1 antibodies were modified by addition of DTPA for 111In-labelling or, in the presence of Iodogen, were 123I-labelled. Delivery of radiolabeled immunoconjugates across the cell memb

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17

Appiah, Kubi George. "Development of Peptidomimetic Inhibitors Against Intracellular Targets." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587519549871245.

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18

Akroush, Muftah Emhemed. "Optimal Linear Filtering For Weak Target Detection in Radio Frequency Tomography." University of Dayton / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=dayton158273299902246.

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19

Nadal, Bufi Ferran. "Peptide-based drugs to inhibit LDH5, a potential target for cancer therapy." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/232526/1/Ferran_Nadal%20Bufi_Thesis.pdf.

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This thesis investigates novel strategies to target lactate dehydrogenase 5 (LDH5), a protein involved in cancer. After decades of research without success, this thesis reports the development of the first molecules able to inhibit the activity of LDH5 with an alternative mechanism of action: disrupting its structure. To do that, an emerging class of drugs called peptides are explored. The lead peptide of this work successfully kills breast cancer cells via LDH5 inhibition. The validation of this strategy is relevant because it can be applied to many other cancer targets that have been traditi

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20

Chu, Qian. "I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides". Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11278.

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Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two helical turns in a peptide increase alpha-helical content and protease resistance, enhance target binding affinity, and promote cell penetration. This technology has been applied to the development of cell-permeable ligands targeting several intracellular targets. This dissertation describes efforts to further the development of stapled peptide technology.<br>Chemistry and Ch

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21

Jindi, Elias Sonav. "Evaluation of mechanisms for accessing intracellular targets for protein-based drugs." Thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445320.

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Over the years, biological drugs have evolved and have made breakthroughs in diseases associated with extracellular proteins. However, intracellular proteins that cause disease progression are still largely inaccessible. Examples of diseases that are caused by an intracellular aggregation of proteins are neurodegenerative diseases such as Parkinson's disease, Huntington's disease (HD), and Alzheimer's disease (AD). The purpose of the work is to find a strategy to reach the neurons intracellularly. The goal is to be able to design a biological drug that enters the neuron by investigating differ

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22

Van, der Merwe P. J. "The design of a monostatic, ultra wide band,VHF, pulse radar for detection of close-in targets." Thesis, Stellenbosch : University of Stellenbosch, 2003. http://hdl.handle.net/10019.1/1709.

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Thesis (MScEng (Electrical and Electronic Engineering))--University of Stellenbosch, 2003.<br>Ground penetrating radar is currently proving itself as an invaluable tool for the prediction of geological structures in the mining environment. Borehole radar is a specific application of this technology, useful in the prediction of the course of rock layers between boreholes ahead of mining. Establishing borehole radar as an industrial tool requires a system that is more userfriendly and easier to deploy than the bi-static radar systems currently available. The development of a monostatic rada

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23

Balasso, Anna. "Towards the development of new strategies for targeted and controlled drug delivery." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3424679.

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In this contribution the design and development on new approaches for targeted or controlled drug delivery is proposed. The selected starting material for the synthesis of these drug delivery systems (DDSs) was pullulan. Pullulan is a natural and linear polysaccharide that possesses excellent water solubility, biocompatibility and biodegradability. In virtues of the presence of multiple anchoring points along its chain, pullulan represents also an ideal carrier to build up colloidal drug delivery systems. Initially, pullulan oxidation was performed and deeply investigated as a convenient met

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24

Cardarelli, Francesco. "Nanostructuring HIV-1 Tat arginine-rich motif for targeted cellular delivery." Doctoral thesis, Scuola Normale Superiore, 2009. http://hdl.handle.net/11384/85826.

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25

Barreau, Kristell. "Le peptide NFL-TBS, 40-63 dérivés des neurofilaments : Agents thérapeutique prometteur pour cibler et manipuler les cellules souches neurales et les cellules de glioblastomes Review of Clinical Trials Using Neural Stem Cells The Neurofilament‐Derived Peptide NFL‐TBS.40‐63 Targets Neural Stem Cells and Affects Their Properties The carbocyanine dye DiD labels in vitro and in vivo neural stem cells of the subventricular zone as well as myelinated structures following in vivo injection in the lateral ventricle." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0087.

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Les travaux menés au laboratoire ont mis en évidence des sites de liaison de la tubuline (TBS pour Tubulin Binding Site) sur les filaments intermédiaires, tels que les neurofilaments (NFs), qui sont spécifiquement exprimés par les neurones. Le peptide NFL-TBS.40-63 qui correspond à la séquence en acide aminés du TBS situé sur la sous unité légère des NFs, a montré des propriétés anti-glioblastomes in vitro et in vivo, sans effet sur les cellules saines environnantes (neurones et astrocytes). De plus, Il est aussi capable d’induire la différenciation et la maturation des précurseurs d’oligodend

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26

Lubda, Markus. "Target-Site Penetration of Active Ingredients in Human Skin." Phd thesis, 2020. https://tuprints.ulb.tu-darmstadt.de/14169/1/Dissertation_Markus%20Lubda.pdf.

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The skin is a major physical and immunological barrier to the environment, and thus, percutaneous delivery of drugs or active pharmaceutical molecules (APIs) faces a unique set of hurdles. The efficacy of these active ingredients is governed by their release into the underlying tissue, especially when administered topically. However, the factors driving penetration in dermal and transdermal delivery systems remain poorly understood, and robust methods, models, and controls are important to bridge this gap in knowledge. The aim of this study is to understand what influences skin penet

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27

Lu, Chang-Hsuan, and 盧長軒. "Dynamic Response of Concrete Target subject to High Speed Projectile Penetration." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/09149689746501581423.

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碩士<br>國立臺灣大學<br>工程科學及海洋工程學研究所<br>99<br>In this study, numerical simulation methods to analysis the dynamic response of concrete subjected to penetration of high speed projectile. The effects of large strain, high strain rate and high pressure on the dynamic behavior have been investigated. The LS-DYNA finite element analysis software was used for numerical simulation, and the characteristic of two different models of concrete materials: Mat_Johnson_Holmquist_Concrete and Mat_Soil_Concrete were compared. First, a reasonable numerical model was examined through three parameters: the effects of e

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28

Shih, Chieh-Fang, and 石傑方. "Research on Parameter Optimization of a Real- time Target Recognition System for a Multi-layer Mediums Penetration－Using the Response Surface Method." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/jhh6xf.

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碩士<br>國立臺灣科技大學<br>高分子系<br>94<br>In order to find the best combination of the recognition rate and recognition time, we apply the central composite design of the Response Surface Method（RSM）of experimental design to analyze two factors, “window size” and “recognition period”, and use the Minimum distance classifier which applied in the digital signal processor (DSP) of a penetrator to recognize the features of a penetrating accelerometer.

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29

Liu, Chenyue, and 劉承岳. "Research on the Behavior of Projectile Penetrating Aluminum Target by Using Spherical Cavity Expansion Theory." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/15485138226402011569.

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碩士<br>國防大學理工學院<br>兵器系統工程碩士班<br>99<br>This study is to investigate the behavior of 0.30-inch armor piercing projectile penetrating aluminum target, focusing on the factors affecting penetration depth, by spherical cavity expansion theory. We performed theoretical analysis, numerical simulation and experiments of projectile impacting aluminum target to obtain data of penetration depth and then to compare and analyze them. Three parts are included in this study: 1.The equation of penetration depth by spherical cavity expansion theory was derived. 2.The experiments of 0.30-inch armor piercing proj

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30

Malof, Jordan. "Statistical Models for Improving the Rate of Advance of Buried Target Detection Systems." Diss., 2015. http://hdl.handle.net/10161/11336.

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<p>The ground penetrating radar (GPR) is one of the most popular and successful sensing modalities that have been investigated for buried target detection (BTD). GPR offers excellent detection performance, however, it is limited by a low rate of advance (ROA) due to its short sensing standoff distance. Standoff distance refers to the distance between the sensing platform and the location in front of the platform where the GPR senses the ground. Large standoff (high ROA) sensing modalities have been investigated as alternatives to the GPR but they do not (yet) achieve comparable detection

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31

Korostiy, Svitlana. "Spectroscopic investigation of the charge dynamics of heavy ions penetrating solid and gaseous targets." Phd thesis, 2007. http://tuprints.ulb.tu-darmstadt.de/777/1/Dissertation_small2.pdf.

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This thesis presents the study of the slowing down process of fast heavy ions inside matter. In the framework of this research, the influence of the target density on the stopping process is investigated. Experiments on the interaction of 48Ca6+ - 48Ca10+ and 26Mg5+ ion beams with initial energies of 11.4 MeV/u and 5.9 MeV/u with solid and gaseous targets have been carried out. A novel diagnostic method, X-ray spectroscopy of K-shell projectile radiation, is used to determine the ion charge state in relation to its velocity during the penetration of fast heavy ions inside the stopping material

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32

Korostiy, Svitlana [Verfasser]. "Spectroscopic investigation of the charge dynamics of heavy ions penetrating solid and gaseous targets / von Svitlana Korostiy." 2007. http://d-nb.info/983456062/34.

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33

Chiu, Ling-Yuan, and 邱鈴媛. "Ground penetrating radar imaging of archaeological targets using two-dimensional discrete wavelet transform with adaptive Wiener filter." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/31886431394117094410.

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34

Kan, Stanislav. "Development of airway epithelial targeted nanoparticles loaded with TLR7 agonist for asthma therapy." Thesis, 2021. http://hdl.handle.net/1959.13/1422799.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Acute asthma flares represent the major cause of healthcare resource consumption and prevention of acute asthma exacerbation remains a major currently unmet therapeutic need in asthma control. Respiratory viruses, most often rhinoviruses (RVs), are the most frequent trigger of acute asthma exacerbations. Airway epithelial cells (AECs) are the site RV infection and initiate the host response to infection which is a key determinant of disease outcome. Endosomal toll like receptor 7 (TLR7) is a potential therapeutic target for asthma exacerbation

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35

Gately, Maura. "Application of cationic cell-penetrating peptides to the intratumoral targeted delivery of breast cancer therapeutics." Thesis, 2020. https://hdl.handle.net/2144/41244.

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Breast cancer is one of the leading causes of cancer related deaths among women worldwide. Due to the significance and prevalence of this disease, novel therapeutics have recently been explored due to conventional breast cancer therapy having numerous limitations, including multi-drug resistance and extensive off-target side effects. Cell-penetrating peptide-based drug delivery systems are among these therapies and have recently started to undergo clinical trials, hypothesized to hit markets in the near future upon approvals. While these peptides confer their own challenges and limitations, th

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36

Mourtada, Rida. "A Journey down the Cell Death Pathway of Mitochondria-targeted Chlorambucil." Thesis, 2012. http://hdl.handle.net/1807/33466.

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Our lab recently demonstrated that retargeting an alkylating agent, chlorambucil (Cbl), to the mitochondrion is a viable strategy to restore drug activity and overcome drug resistance in cancer. The mechanism of action of the mitochondria-targeted chlorambucil (mt-Cbl) was studied using a cervical carcinoma model. It was discovered that mt-Cbl bound to mitochondrial DNA and various mitochondrial proteins. A ρ° model revealed that the toxicity of mt-Cbl is largely dependent on its protein targets. Damage induced by mt-Cbl was found to result in the activation of several modes of caspase-indepe

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37

Chamberlain, Graham Ross. "Mitochondria-targeted Doxorubicin is Active and Resistant to Drug Efflux." Thesis, 2012. http://hdl.handle.net/1807/33360.

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Several families of highly effective anticancer drugs are selectively toxic to cancer cells because they interfere with nucleic acids synthesis. Many such drugs are pumped out of cells faster than they can reach their targets, which limits efficacy and renders many tumors drug-resistant. By delivering a drug to the mitochondria of mammalian cells – an organelle where nucleic acids synthesis also occurs – efflux could be prevented through sequestration. Doxorubicin, a topoisomerase II inhibitor, was used as proof-of-principle for this concept due to its susceptibility to resistance. When doxor

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38

Miller, Michelle Lee. "Coupling ground penetrating radar applications with continually changing decomposing human targets an effort to enhance search strategies of buried human remains /." 2002. http://etd.utk.edu/2002/MillerMichelle.pdf.

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Thesis (M.A.)--University of Tennessee, Knoxville, 2002.<br>Title from title page screen (viewed Sept. 6, 2002). Thesis advisor: Murray K. Marks. Document formatted into pages (xii, 101 p. : ill. (some col.), photo). Vita. Includes bibliographical references (p. 95-100).

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39

Mikhail, Andrew. "Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors." Thesis, 2013. http://hdl.handle.net/1807/65519.

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Recent advancements in pharmaceutical technology based on principles of nanotechnology, polymer chemistry, and biomedical engineering have resulted in the creation of novel drug delivery systems with the potential to revolutionize current strategies in cancer chemotherapy. In oncology, realization of significant improvements in therapeutic efficacy requires minimization of drug exposure to healthy tissues and concentration of the drug within the tumor. As such, encapsulation of chemotherapeutic agents inside nanoparticles capable of enhancing tumor-targeted drug delivery is a particularly prom

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