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Готові списки джерел за темами / Telomeres And Telomerase Biology / Дисертації

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Дисертації з теми "Telomeres And Telomerase Biology"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Sherwood, Rebecca. "The Effect of the Copy Number of the Telomerase RNA Gene on the Elongation of Telomeres in Saccharomyces cerevisiae." Thesis, Boston College, 2008. http://hdl.handle.net/2345/532.

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Thesis advisor: Clare O'Connor<br>Telomeres are repeated sequences at the ends of chromosomes, which promote chromosome stability by preventing the loss of necessary nucleotides from the DNA with successive rounds of replication. Telomeres are elongated by the enzyme telomerase, which has both a protein component and an RNA component. In the yeast Saccharomyces cerevisiae, the TLC1 gene encodes the RNA component of the enzyme. Telomerase RNA interacts with several proteins to perform its function, including the Ku protein, which binds to the end of the DNA and helps to recruit telomerase to th

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2

Alotaibi, Mohammad Kdaimes H. "Genes required to maintain telomeres in the absence of telomerase in Saccharomyces cerevisiae." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12589/.

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In the absence of telomerase, Saccharomyces cerevisiae telomeres erode leading to senescence. Rare cells can survive after this stage as they can elongate their telomeres utilizing homologous recombination. Two different types of survivors can be easily distinguished by Southern blot. Type I survivor cells, elongate the telomere by amplifying Y elements and require RAD51, RAD54, RAD55 and RAD57 for establishment. Type II survivors elongate their telomere by amplifying TG1-3 repeats, however, they require the following genes to be established: RAD50, MRE11 and XRS2, RAD59, SGS1 and KU80 in some

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3

Brault, Marie Eve. "Telomeres and telomerase: role in human cancer, the premature aging syndrome dyskeratosis congenita and frailty." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117043.

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Telomeres and telomerase stand at a junction of cellular processes that govern aging, cancer and disease. Premature aging syndromes and age-related diseases are characterized by short telomeres which compromise cell function and viability, whereas cancer cells are able to reactivate telomerase or alternative lengthening of telomeres (ALT) mechanisms to maintain their telomeres and become immortal.Telomeres and telomerase represent very attractive targets for the development of anticancer therapies. However, there is concern that these therapies may lead to cell resistance, including the reacti

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4

Fakhoury, Johans. "Conserved and divergent mouse and human telomerase and telomere regulation: implications for the development and validation of telomerase and telomere-specific anticancer strategies." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=94905.

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Telomerase synthesizes telomeric sequences and is minimally composed of a reverse transcriptase (RT) (TERT) and RNA (TR). We reconstituted heterologous mouse and human TERT-TR and chimeric mTERT-hTERT-hTR complexes in vitro and in immortalized human alternative lengthening of telomere (ALT) cells. Our data suggest that species-specific determinants of activity, processivity, and telomere function map not only to TR, but also to the TERT component. hTERT-hTR, but not heterologous TERT-TR complexes, nor chimeric mTERT-hTERT-hTR complexes, significantly reduced the percentage of chromosomes witho

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5

McKevitt, Tom Patrick. "A study of telomere and telomerase biology in the dog and cat." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443374.

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6

D'Souza, Yasmin. "Processivity domains within human telomerase reverse transcriptase that regulate telomere length and immortalization." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116879.

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Short, repetitive G-rich DNA sequences present at telomeres are synthesized by telomerase, a ribonucleoprotein consisting of a catalytic subunit, the telomerase reverse transcriptase, TERT, and an integrally associated RNA, TR. Human TERT (hTERT) can repetitively reverse transcribe its short RNA template, acting processively to add multiple telomeric repeats onto the same DNA substrate. We investigated if threshold levels of telomerase activity and processivity are required to maintain telomere length and/or function and immortalize human cells with limited lifespan. Specifically, we assessed

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7

Mangosh, Tawna L. "SLX4 Interacting Protein (SLX4IP): A Vital Primer for Alternative Lengthening of Telomere (ALT)-like Processes Promoting Replicative Immortality in Castration-resistant Prostate Cancer with Androgen Receptor Loss." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1623255136624147.

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8

Denham, Elizabeth. "The Effects of Relocating the Ku-binding Stem-loop of Telomerase RNA on Telomere Healing Events." Thesis, Boston College, 2008. http://hdl.handle.net/2345/528.

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Thesis advisor: Anne E. Stellwagen<br>Thesis advisor: Clare O'Connor<br>In most eukaryotes, the enzyme telomerase adds telomeric DNA repeats to the 3' ends of chromosomes in order to stabilize them and protect them from degradation. In the budding yeast Saccharomyces cerevisiae, telomerase is a ribonucleoprotein complex consisting of multiple protein subunits and an approximately 1.3 kb RNA component termed TLC1. Among the various proteins involved in telomerase, Ku is a heterodimer that binds both to double-stranded DNA and to a 48 nucleotide stem loop on the TLC1 RNA. Beyond its function of

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9

VENTURINI, LORENZA. "TELOMERE MAINTENANCE MECHANISMS IN TUMOR OF MESENCHYMAL ORIGIN: EVALUATION OF PROGNOSTIC SIGNIFICANCE AND CHARACTERIZATION OF RELEVANT MOLECULAR PATHWAYS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/171334.

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A limitless proliferative potential is one of the hallmarks of tumour cells and can be achieved through the activation of telomere maintenance mechanisms (TMM), which rely on telomerase reactivation (TA) or, alternatively, on recombination-based processes known as alternative lengthening of telomeres (ALT). Since a substantial fraction of tumours of mesenchymal origin utilizes ALT mechanisms, they represent an interesting model to study the molecular pathways involved in the activation of TMM. With the present work, we extended our knowledge about the prevalence and the prognostic significan

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10

Aisenberg, Jeremy Charles. "A Critical Review of Telomerase Biology and Model Systems for the Study of Telomerase." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/2120.

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11

Khondaker, Shanjadia. "Telomerase regulation by alternative slicing." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110548.

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Telomerase, the main mechanism for telomere maintenance, is active in 85% of cancer cells. Telomerase inhibition leads to telomere erosion, chromosome damage, and cell death, thereby validating the enzyme as a prime target in the search for anticancer therapies. hTERT genome analysis revealed the potential for complex splicing patterns that may reflect a specific aspect of telomerase regulation in proliferation, differentiation and apoptosis (Sykorova and Fajkus 2009).A number of alternatively-spliced TERT mRNAs in vertebrates and plants have been identified, yet their role in telomere mainten

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12

Wang, Zhuo. "Extracellular Inflammatory Signaling from Dysfunctional Telomeres." Thesis, University of the Sciences in Philadelphia, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10692989.

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<p> Telomere dysfunction describes the catastrophic damage at telomeres, which often leads to genomic instability at the cellular level. There is rising evidence showing that telomere dysfunction also influences the extracellular environment with the inflammatory response. However, little is known about the molecular mechanism of this dysfunctional telomere-associated inflammation. In this dissertation, we identified extracellular forms of Telomeric repeat-containing RNA (TERRA), and demonstrated it might play a role in mediating the crosstalk of telomere dysfunction and inflammation. We found

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13

Huard, Sylvain. "Human telomerase determinants of processivity and fidelity." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85075.

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Telomeres are dynamic nucleoprotein complexes that protect the fragile termini of chromosomes. Without telomeres, chromosome ends are recognized as DNA breaks and inclined to nucleolytic degradation and end-to-end fusions. Telomeres consist of DNA repeats that are synthesized by telomerase, a specialized reverse transcriptase (RT) enzyme minimally composed of a catalytic protein subunit (TERT) and an essential RNA component (TR). Although the functional aspects of telomerase are not well elucidated, this ribonucleoprotein enzyme clearly regulates cellular life-span through its ability t

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14

Qing, Hua. "TELOMERASE REVERSE TRANSCRIPTASE IN ATHEROSCLEROSIS." UKnowledge, 2017. http://uknowledge.uky.edu/pharmacol_etds/19.

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Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase and the limiting factor for the enzyme activity. The expression of TERT and telomerase activity is increased in atherosclerotic plaques. However, the role of TERT dysregulation during atherosclerosis formation remains unknown. The work herein first identified a multi-tiered regulation of TERT expression in smooth muscle cells (SMC) through histone deacetylase (HDAC) inhibition. HDAC inhibition induces TERT transcription and promoter activation. At the protein level in contrast, HDAC inhibition decreases TERT protein

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15

Moriarty, Tara J. "Regulation of telomerase-specific catalytic functions by nucleic acid interactions and human telomerase reverse transcriptase N-terminal domains." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85628.

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Telomerase is an unusual reverse transcriptase (RT) that catalyzes the de novo addition of telomeric DNA repeats to telomeres. Telomerase activity counteracts the progressive loss of telomeric DNA over successive rounds of DNA replication, and is important for the immortality of most eukaryotic cells. Telomerase is distinct from other RTs in that its catalytic subunit (TERT: telomerase reverse transcriptase) stably associates with a telomerase RNA (TR) component that contains a short template used to direct synthesis of telomeric repeats. Telomerase also exhibits a unique, repeat additi

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16

Bachand, François. "Functional reconstitution and RNA-protein interactions of human telomerase." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38460.

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Telomerase is a ribonucleoprotein (RNP) enzyme responsible for the replenishment of repetitive DNA sequences present at the ends of most eukaryotic chromosomes. Telomerase is minimally composed of a protein catalytic subunit, the telomerase reverse transcriptase (TERT), and an RNA subunit. Using a small single-stranded segment (7--11 nucleotides) of the telomerase RNA as a template, the active site of the TERT catalytic subunit adds complementary nucleotides onto telomeric DNA. The primary goal of the work presented in this thesis was to biochemically and functionally characterize the human te

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17

LILLARD, KATHERINE L. "THE BLM HELICASE FUNCTIONS IN ALTERNATIVE LENGTHENING OF TELOMERES." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1097164165.

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18

Xu, Mengyuan. "The Role of Shelterin Proteins in Telomere DNA Protection and Regulation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1585760345643995.

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19

Taboski, Michael. "Human telomerase regulation by associated proteins and alternatively spliced mRNA variants." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82434.

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Human telomerase is a ribonucleoprotein complex, minimally composed of a catalytic subunit, hTERT and an RNA component, hTR that contains the template used to synthesize telomere DNA. Telomerase is present in over 80% of all cancer cells. Therefore, an understanding of telomerase regulation is important for cancer research. This thesis work was focused upon the study of telomerase regulation by telomerase associated proteins and alternatively spliced hTERT mRNA variants. Tandem affinity purification (TAP) and immunopurifications with anti-hTERT antibody were used to visualize potential

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20

Kwan, Ricky. "The identification and characterization of EWS as a telomerase-associated protein." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121410.

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Telomerase is a ribonucleoprotein complex responsible for immortalizing 85% of all human malignant tumors, making telomerase regulation a very attractive target for the development of anti-cancer therapeutics. Thus far, many proteins have been identified that regulate human telomerase biogenesis, activity, trafficking, recruitment and degradation. By comparison, there have been very few proteins identified to associate with mouse telomerase. Due to the importance of mouse models in the development of anti-cancer therapeutics, investigation of mouse telomerase-associated proteins is required

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21

To, Teng Teng. "Structural studies of three enzymes : telomerase, the methyltransferase CobJ and pectate lyase." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/691.

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This thesis investigates the structure and function of three enzymes of biotechnological and biomedical interest: telomerase from Caenorhabtidis elegans, pectate lyase from Bacillus subtilis and the methyltransferase CobJ from Rhodobacter capsulatus. Telomerase is a ribonucleoprotein found in all eukaryotes and its function is to maintain telomere length, sustain chromosome integrity and circumvent the end-replication problem. The protein requires two subunits to function, telomerase reverse transcriptase (TERT), the catalytic component, and an intrinsic RNA template (TR). The TR makes telomer

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22

Sandhu, Ranjodh Singh. "Telomere structure and maintenance in Trypanosoma brucei." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1419265625.

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23

Vernasco, Ben Joseph. "A Proximate Perspective on the Cooperative Behavior of a Lekking Passerine." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/102660.

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Elucidating the mechanisms responsible for driving individual variation in behavior is a foundational question in organismal biology. Answering these types of questions is necessary for understanding how tradeoffs are mediated as well as potential constraints on evolutionary responses to selection. In Chapter I, I synthesize the evidence suggesting that testosterone plays a central role in driving individual variation in cooperative reproductive behaviors and mediating the tradeoff between cooperation and competition. The subsequent chapters of my dissertation then focus on understanding the m

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24

Thanasoula, Maria. "ATM/ATR-dependent responses to dysfunctional telomeres at the G2/M transition." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:b9f806e3-88e5-4dc4-b2e9-8ecf854249d1.

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Mammalian telomeres are nucleoprotein complexes at the end of chromosomes containing a specific protein complex, called shelterin. Shelterin protects chromosome ends from the DNA damage response (DDR), by facilitating the formation of a telomeric capping structure, called the T-loop. During their elongation in S phase, telomeres become transiently uncapped and can be sensed as DNA damage in G2 phase. This leads to the recruitment of DDR factors, such as phosphorylated histone H2AX (γH2AX), to the telomeres forming the so-called, telomere dysfunction-induced foci (TIFs). My PhD work described h

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25

Deault-Bonin, Marie. "Microcell-mediated chromosome transfer shows that inhibition of telomerase activity occurs at the transcriptional level." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84503.

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We hypothesized that if normal cells carry a regulator which is inactivated in cancer cells, the transfer of this regulator from a normal cell to a cancerous one should inactivate the telomerase. Available in the laboratory was a panel of mouse/human microcell hybrids, each containing a tagged normal human chromosome fragment integrated into a mouse melanoma (telomerase-positive) background. We screened these hybrids for telomerase activity using both the polymerase chain reaction (PCR)-based telomeric repeat amplification protocol (TRAP) assay and mTERT mRNA amplification.<br>We were a

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26

Jackson, Mark Richard. "The identification and validation of Auger electron-emitting radiopharmaceuticals targeting telomerase for cancer therapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:040d10f6-c69b-41d3-b73f-7c47c4053db2.

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Telomerase is expressed in the majority (>85%) of tumours but not in differentiated normal tissue. This enzyme catalyses the elongation of telomeres – a process critical for continued cell proliferation. Telomerase is a potential novel target for molecularly-targeted radiotherapy (mRT), due to its nuclear localization and expression profile. The radiolabelling of telomerase inhibitors may accelerate and enhance the cytotoxicity of such molecules, as a result of irradiation of the DNA. An oligonucleotide targeting telomerase RNA (hTR), shown to inhibit enzyme activity in vitro, was selected for

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27

Lee, Hyemin [Verfasser]. "mEst1A (mouse ever shorter telomeres 1A) regulates telomere length and RNA quality control in murine stem cells / Hyemin Lee." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2012. http://d-nb.info/1024534235/34.

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28

Beyer, Tracey Elaine, and Tracey Elaine Beyer. "Ontogeny of Unstable Chromosomes Formed by Telomere Replication Error." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621103.

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The integrity of the genome relies on the maintenance of chromosomes, the structural embodiment of the genetic material. Disruption of chromosome replication can lead to extensive genomic rearrangements, spanning kilobase (Kb) to megabase (Mb) regions. Some chromosome rearrangements are inherently dynamic, beginning as a single unstable rearrangement from which multiple rearrangements emerge. The rare formation and transient behavior of unstable chromosomes renders their study challenging. Here I characterize the genetic ontogeny of unstable chromosomes in a budding yeast model, from initial r

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29

Edwards, Deanna. "RELATIONSHIPS BETWEEN TELOMERIC SEQUENCES AND STRUCTURES, DNA REPLICATION, AND THE FUNCTION OF THE WERNER SYNDROME PROTEIN." UKnowledge, 2012. http://uknowledge.uky.edu/toxicology_etds/3.

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All human chromosomes end with protective structures called telomeres, which consist of thousands of double-stranded TTAGGG repeats and end in a 3’ guanine-rich overhang. These structures shorten normally during each round of replication, and extremely short telomeres along with telomere dysfunction are thought to contribute to the development of aging and cancer. Although many proteins have roles in telomere maintenance, WRN, which is a 3’ to 5’ helicase that is deficient in the premature aging disorder Werner’s syndrome, has been proposed to play multiple roles at telomeres. In this study, I

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30

Arbuckle, Jesse Herbert. "Identification and Characterization of the Human Herpesviruses 6A and 6B Genome Integration into Telomeres of Human Chromosomes during Latency." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/2989.

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While the latent genome of most Herpesviruses persists as a nuclear circular episome, previous research has suggested that Human Herpesvirus 6 (HHV-6) may integrate into host cell chromosomes, and be vertically transmitted in the germ-line. Because the HHV-6 genome encodes a perfect TTAGGG telomere repeat array at the right end direct repeat (DRR) and an imperfect TTAGGG repeat at the end of the left end direct repeat (DRL), we established a hypothesis that during latency, the HHV-6A and HHV-6B genome integrates into the telomeres of human chromosomes through homologous recombination with the

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31

BUEMI, VALENTINA. "Telomerase regulation by non-coding RNAs." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2912144.

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I telomeri sono le regioni terminali dei cromosomi ed hanno il ruolo fondamentale di proteggere l’estremità del cromosoma stesso. Per ragioni intrinseche al suo meccanismo di duplicazione, il DNA telomerico non viene completamente replicato, provocando un accorciamento delle estremità cromosomiche ad ogni ciclo di replicazione, che causa un blocco della proliferazione cellulare noto come senescenza. Per controbilanciare questo fenomeno, le cellule tumorali possono riattivare la telomerasi, un enzima che sintetizza nuove ripetizioni telomeriche, o attivare meccanismi alternativi che si basano s

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32

Chee, Meng May. "Investigations into telomere biology in systemic sclerosis." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3615/.

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Systemic sclerosis (SSc) is a complex multisystem autoimmune connective tissue disease of yet unknown aetiology. It is characterised by vascular damage, autoimmunity and progressive fibrosis in the skin and internal organs, with 2 main subsets of disease: diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc), classified mainly according to skin involvement. Although there has been tremendous progress in the understanding and treatment of autoimmune diseases in the last 20 years, SSc remains a disease with high morbidity and mortality, with no proven treatments that improve long-term

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33

Nanavaty, Vishal P. "Function of Telomere Protein RAP1 and Telomeric Transcript in Antigenic Variation in Trypanosoma Brucei." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1485424039406009.

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Tan, Thomas Ching-Jen. "Telomere biology in the freshwater planarian Schmidtea mediterranea." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12308/.

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Freshwater planarian Schmidtea mediterranea is an emerging model for studying in vivo gene functions and regulation in native cell niches. The obligate asexual strain of this species reproduces by fission, in which succession of soma occurs without passing through the germline. To achieve this somatic immortality the somatic stem cells need to overcome the end replication problem. Therefore it can be hypothesised that somatic telomere maintenance in asexual S. mediterranea must possess a germ-like property, with which age-related erosions can be adequately repaired. In this PhD project, the te

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35

AGUADO, PEREZ JULIO. "THE ROLE OF TELOMERIC RNA AT DYSFUNCTIONAL TELOMERES AND ITS IMPACT ON SENESCENCE AND AGING." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/556299.

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A novel class of small non-coding RNAs discovered in our laboratory, termed DNA damage response RNAs (DDRNAs), has been demonstrated to be generated upon DNA double strand break (DSB) induction, and to be necessary for full DNA Damage Response (DDR) activation. DDRNAs are generated following DSB induction upon transcription of the damaged locus and the synthesis of an RNA precursor further processed by the endoribonucleases DICER and DROSHA. The aim of this PhD dissertation was to investigate the mechanism underlying DDRNA-dependent DDR activation specifically at telomeres, important chromos

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36

Dinami, Roberto. "Telomere regulation by microRNAs in human breast cancer." Doctoral thesis, Università degli studi di Trieste, 2015. http://hdl.handle.net/10077/11120.

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2013/2014<br>Nei vertebrati i telomeri sono strutture specializzate localizzate all’estremità dei cromosomi costituito da sequenze ripetute TTAGGG. L’ accorciamento progressivo del telomero ad ogni divisione cellulare porta ad una disfunzione telomerica e all’attivazione della risposta di danno al DNA alle estremità cromosomiche. L’attivazione del segnale di danno al DNA provoca senescenza o apoptosi, fenomeni legati all’invecchiamento. Per mantenere la funzione del telomero il complesso della telomerasi, costituito dalla componente ad RNA (hTERC) e dalla subunità catalitica (hTERT), aggiung

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37

Chilton, Warrick. "The acute effects of aerobic exercise on Leukocyte Telomere biology." Thesis, Federation University Australia, 2018. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/166510.

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Doctor of Philosophy<br>Habitual exercise is unequivocally associated with decreased all-cause mortality and morbidity. Despite the strength of the association, a large part of the decreased risk is physiologically unaccounted for. Accumulating evidence indicates that leukocyte telomere length (LTL) may be one such explanatory mechanism. Telomeres are specialized deoxyribonucleic acid (DNA) sequences located at chromosomal ends where they protect the genomic DNA from enzymatic degradation. Excessive and/or premature telomere shortening in leukocytes is associated with a host of chronic disease

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Silva, Filipa Isabel Serra e. "Mistranslation and telomere stability." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7648.

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Mestrado em Biologia Aplicada<br>The regulation of a stable proteome is crucial for the cell homeostasis. The translation process from the nucleotide sequence of a gene into the aminoacid sequence of a protein is associated with a basal error of 10-4 which the cell deals with through quality control mechanisms. The misincorporation of aminoacids into de novo synthesized proteins tends to rise when the cell is exposed to stressful conditions. The increase of dysfunctional proteins produced by mistranslation may induce expression of genes related to stress response and genome destabilizat

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39

PANDYA, UNNATI. "Trypanosoma Brucei Telomere Functions In Antigenic Variation." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1406241248.

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40

Alcaraz, Pérez Francisca. "El pez zebra (Danio rerio) como modelo de estudio in vivo del papel de la telomerasa en la hematopoyesis= The zebrafish (Danio rerio)as a model to stydy in vivo the role of telomerase in hematopoiesis." Doctoral thesis, Universidad de Murcia, 2014. http://hdl.handle.net/10803/134061.

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Objetivos. En el presente trabajo se han cumplido dos objetivos concretos: 1. Desarrollo de un nuevo sistema chivato basado en la luciferasa para el estudio de promotores tanto constitutivos como inducibles en el contexto de un organismo completo. 2. Estudio del papel extracurricular del componente de ARN de la telomerasa (TR) en la hematopoyesis usando el pez cebra como modelo. - Metodología. Embriones de pez cebra han sido manipulados genéticamente mediante la microinyección de plásmidos, morfolinos y ARN (solos o en combinación) en el estadío de desarrollo de 1-8 células para recrear las di

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41

Turner, Rachel. "Relationships between nuclear lamins and telomere biology in progeroid laminopathies and cancer." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/32257.

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Telomeres are essential for maintaining the integrity of the genome. Shortening and dysfunction of telomeres initiates cellular senescence, halting further cell division, and instigating alterations in biological processes which contribute to ageing. Progeroid syndromes are disorders of ageing. Patients exhibit not only an early external appearance of old age, but several age-related diseases including osteoporosis, muscle wasting and cancer. Laminopathies are diseases caused by mutations in LMNA, the gene encoding the key nuclear matrix component lamin A. Some mutations result in progeroid ph

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42

Maddison, Rachelle Louise. "Telomeres in the absence of telomerase in Saccharomyces cerevisiae." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30365.

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The aim of this study was to screen a list of proteins which were suggested to have roles in telomerase-independent telomere maintenance. Of the proteins screened some had no effect on post-senescent survival (Nup53p and Crp1p). Other proteins are suggested to function in post-senescent survival (M1p1p, M1p2p, Dhh1p, Rrm3p and Stm1p).;The importance of the affect of the chromatin context on post-senescent survival was identified with proteins involved in chromatin remodelling (Chd1p, Isw1p and Isw2p) and modifying (Rdp3p) identified as also affecting survival. Of particular interest was the st

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43

Marie-Egyptienne, Delphine. "Characterization of distinct and conserved features between ciliate and vertebrate telomerases." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18815.

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Telomeres are nucleoprotein structures that protect the ends of chromosomes from recombination and fusion. Telomeres are prefentially maintained by the enzyme telomerase. Telomerase is a reverse transcriptase, minimally composed of two core components, a catalytic subunit, TElomerase Reverse Transcriptase (TERT) and an RNA subunit, Telomerase RNA (TR) that carries the template for the replenishment of the telomeres. Telomerase is present throughout evolution, from ciliates and yeasts to vertebrates. Likely because it performs reverse transcription to maintain telomeres in these organisms, telo

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44

Albanell, Mestres Joan. "Telomerasa: regulación, diana terapéutica y significado clínico en neoplasias humanas." Doctoral thesis, Universitat Autònoma de Barcelona, 2001. http://hdl.handle.net/10803/4370.

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Las células malignas deben adquirir un potencial de replicación ilimitado (inmortalidad celular) para la formación de tumores avanzados. La adquisición de inmortalidad celular depende de la reactivación de la telomerasa, una enzima que permite compensar el problema de replicación terminal del ADN asociado a cada división celular. En una serie de estudios presentados en esta tesis, se demuestra:<br/>1. La telomerasa es una enzima regulable en células tumorales humanas.<br/>2. Los tumores humanos expresan actividad telomerasa y su expresión se asocia a estadío tumoral, índice proliferativo y dif

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45

Reichert, Sophie. "Facteurs déterminant la longueur des télomères et implications dans les compromis évolutifs." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01023750.

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Une question fondamentale de la biologie évolutive porte sur la compréhension des mécanismes sous-tendant les processus évolutifs et l'évolution des compromis entre les traits d'histoire de vie. Parmi ces mécanismes, les télomères suscitent un intérêt particulier. Les télomères sont localisés à l'extrémité des chromosomes eucaryotes et participent à la sénescence cellulaire et au vieillissement des individus. La longueur des télomères est susceptible de donner des indications sur le mode de vie et l'état physiologique des organismes. Le but de cette thèse a été de comprendre quels sont les fac

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46

Wang, Jinyu. "Telomere Regulation and Heterochromatin Formation in Yeasts." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1474025783681296.

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47

Cranert, Stacey. "The functional evolution of telomere proteins in Tetrahymena thermophila." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415283984.

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48

Moye, Aaron Lavel. "Understanding the relationship between telomeres, telomerase, and DNA G-quadruplexes." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17713.

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Cancer cells elongate their telomeres - G-rich repetitive sequences found at the end of linear chromosomes, allowing limitless replicative potential in these cells. Approximately 85% of cancers use telomerase to extend telomeres, making it an attractive potential anti-cancer target. The G-rich nature of telomeres allows the formation of DNA G-quadruplex secondary structures. Previous data had demonstrated that telomeric G-quadruplex substrates could not be extended by ciliate telomerase (Zahler et al., 1991). However, while the above observation is true for anti-parallel G-quadruplexes, parall

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49

Lee, Joyce Hiu Yan. "Detection of Alternative Lengthening of Telomeres in Telomerase-Positive Cancers." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17252.

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Immortalisation is a hallmark of cancer and requires activation of a telomere lengthening mechanism (TLM) to counteract natural telomere shortening. There are two TLMs: telomerase, reported in 85% of cancers, and Alternative Lengthening of Telomeres (ALT), reported in 13% of cancers. Because most somatic tissues do not have TLM activity, TLMs are widely regarded as targets for the development of anti-cancer therapies. Preliminary data from the Reddel laboratory indicated that in non-small cell lung carcinoma (NSCLC), ALT was more common than previously reported but mostly at very low levels, a

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50

Maxwell, Patrick Belote John. "Molecular genetic analysis of TART (telomere-associated retrotransposon) in Drosophila melanogaster." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2004. http://wwwlib.umi.com/cr/syr/main.

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